Rank | Gene Set | Z-score |
---|---|---|
1 | DNA deamination (GO:0045006) | 6.14236204 |
2 | ribosomal small subunit assembly (GO:0000028) | 6.09837144 |
3 | viral transcription (GO:0019083) | 5.84830718 |
4 | translational termination (GO:0006415) | 5.69902964 |
5 | maturation of SSU-rRNA (GO:0030490) | 5.59805485 |
6 | translational elongation (GO:0006414) | 5.18564889 |
7 | ribosomal small subunit biogenesis (GO:0042274) | 5.08100062 |
8 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.91652400 |
9 | cotranslational protein targeting to membrane (GO:0006613) | 4.79322805 |
10 | protein targeting to ER (GO:0045047) | 4.77667355 |
11 | ribosomal large subunit biogenesis (GO:0042273) | 4.77106219 |
12 | translational initiation (GO:0006413) | 4.68829837 |
13 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.61930684 |
14 | cellular protein complex disassembly (GO:0043624) | 4.56635750 |
15 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.54205312 |
16 | protein localization to endoplasmic reticulum (GO:0070972) | 4.51865910 |
17 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.42179052 |
18 | nucleobase biosynthetic process (GO:0046112) | 4.40672177 |
19 | viral life cycle (GO:0019058) | 4.38902369 |
20 | DNA replication initiation (GO:0006270) | 4.33793037 |
21 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.33764861 |
22 | pseudouridine synthesis (GO:0001522) | 4.26293086 |
23 | regulation of translational fidelity (GO:0006450) | 4.24243277 |
24 | DNA strand elongation (GO:0022616) | 4.18967934 |
25 | protein complex disassembly (GO:0043241) | 4.16979967 |
26 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.13740930 |
27 | formation of translation preinitiation complex (GO:0001731) | 4.13069052 |
28 | purine nucleobase biosynthetic process (GO:0009113) | 4.07225541 |
29 | proline biosynthetic process (GO:0006561) | 3.99059916 |
30 | macromolecular complex disassembly (GO:0032984) | 3.98320207 |
31 | ribosome biogenesis (GO:0042254) | 3.98027070 |
32 | DNA unwinding involved in DNA replication (GO:0006268) | 3.97223795 |
33 | rRNA processing (GO:0006364) | 3.87337730 |
34 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.77306046 |
35 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.77103385 |
36 | spliceosomal snRNP assembly (GO:0000387) | 3.74326117 |
37 | rRNA metabolic process (GO:0016072) | 3.73955208 |
38 | translation (GO:0006412) | 3.73262407 |
39 | tRNA methylation (GO:0030488) | 3.71501607 |
40 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.58673995 |
41 | ribosome assembly (GO:0042255) | 3.51503464 |
42 | establishment of integrated proviral latency (GO:0075713) | 3.49906923 |
43 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.47185460 |
44 | cellular component biogenesis (GO:0044085) | 3.40717400 |
45 | oxidative phosphorylation (GO:0006119) | 3.39773504 |
46 | mRNA catabolic process (GO:0006402) | 3.39749440 |
47 | telomere maintenance via recombination (GO:0000722) | 3.35203826 |
48 | GDP-mannose metabolic process (GO:0019673) | 3.30173875 |
49 | IMP biosynthetic process (GO:0006188) | 3.29753856 |
50 | RNA catabolic process (GO:0006401) | 3.29733120 |
51 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.27664710 |
52 | termination of RNA polymerase III transcription (GO:0006386) | 3.27664710 |
53 | peptidyl-arginine omega-N-methylation (GO:0035247) | 3.24149013 |
54 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.22994802 |
55 | telomere maintenance via telomere lengthening (GO:0010833) | 3.20482500 |
56 | nucleotide salvage (GO:0043173) | 3.19210249 |
57 | folic acid metabolic process (GO:0046655) | 3.19114774 |
58 | negative regulation of RNA splicing (GO:0033119) | 3.18768229 |
59 | UTP biosynthetic process (GO:0006228) | 3.15487587 |
60 | protein targeting to membrane (GO:0006612) | 3.15309195 |
61 | protein targeting to mitochondrion (GO:0006626) | 3.14374441 |
62 | proteasome assembly (GO:0043248) | 3.14251723 |
63 | transcription from mitochondrial promoter (GO:0006390) | 3.14027026 |
64 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.12141111 |
65 | DNA replication checkpoint (GO:0000076) | 3.10220229 |
66 | DNA topological change (GO:0006265) | 3.10083215 |
67 | negative regulation of B cell apoptotic process (GO:0002903) | 3.09936811 |
68 | metallo-sulfur cluster assembly (GO:0031163) | 3.09505640 |
69 | iron-sulfur cluster assembly (GO:0016226) | 3.09505640 |
70 | nucleobase-containing small molecule interconversion (GO:0015949) | 3.06832510 |
71 | rRNA modification (GO:0000154) | 3.05522173 |
72 | spliceosomal complex assembly (GO:0000245) | 3.04402990 |
73 | negative regulation of mRNA processing (GO:0050686) | 3.04339608 |
74 | histone arginine methylation (GO:0034969) | 3.02360686 |
75 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.00642889 |
76 | mitotic recombination (GO:0006312) | 3.00630293 |
77 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.00542437 |
78 | regulation of mammary gland epithelial cell proliferation (GO:0033599) | 3.00234824 |
79 | IMP metabolic process (GO:0046040) | 2.99358870 |
80 | pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209) | 2.99318876 |
81 | ncRNA processing (GO:0034470) | 2.99125736 |
82 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.99079193 |
83 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 2.98714443 |
84 | base-excision repair, AP site formation (GO:0006285) | 2.97205502 |
85 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.96672771 |
86 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 2.96593824 |
87 | chromatin remodeling at centromere (GO:0031055) | 2.96361726 |
88 | deoxyribonucleotide catabolic process (GO:0009264) | 2.93790241 |
89 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 2.93515473 |
90 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.93432747 |
91 | CENP-A containing nucleosome assembly (GO:0034080) | 2.92937531 |
92 | mitochondrial RNA metabolic process (GO:0000959) | 2.92660673 |
93 | ncRNA metabolic process (GO:0034660) | 2.92137891 |
94 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 2.90186397 |
95 | purine nucleotide salvage (GO:0032261) | 2.89343944 |
96 | viral mRNA export from host cell nucleus (GO:0046784) | 2.88720610 |
97 | pentose metabolic process (GO:0019321) | 2.88619588 |
98 | tRNA aminoacylation for protein translation (GO:0006418) | 2.88606660 |
99 | deoxyribose phosphate catabolic process (GO:0046386) | 2.88382011 |
100 | base-excision repair (GO:0006284) | 2.86325616 |
101 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 2.84079726 |
102 | ATP synthesis coupled proton transport (GO:0015986) | 2.84079726 |
103 | GTP biosynthetic process (GO:0006183) | 2.83238150 |
104 | establishment of protein localization to mitochondrion (GO:0072655) | 2.83170131 |
105 | regulation of mitochondrial translation (GO:0070129) | 2.82716756 |
106 | 7-methylguanosine mRNA capping (GO:0006370) | 2.82563564 |
107 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 2.82451374 |
108 | tRNA aminoacylation (GO:0043039) | 2.82401739 |
109 | amino acid activation (GO:0043038) | 2.82401739 |
110 | guanosine-containing compound biosynthetic process (GO:1901070) | 2.82201499 |
111 | tRNA modification (GO:0006400) | 2.81678684 |
112 | protein localization to kinetochore (GO:0034501) | 2.81045014 |
113 | DNA replication-dependent nucleosome assembly (GO:0006335) | 2.80746180 |
114 | DNA replication-dependent nucleosome organization (GO:0034723) | 2.80746180 |
115 | GMP metabolic process (GO:0046037) | 2.80526594 |
116 | DNA replication-independent nucleosome organization (GO:0034724) | 2.78305719 |
117 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.78305719 |
118 | mitotic nuclear envelope disassembly (GO:0007077) | 2.77998678 |
119 | pyrimidine nucleoside monophosphate metabolic process (GO:0009129) | 2.77848780 |
120 | 2-deoxyribonucleotide metabolic process (GO:0009394) | 2.77743190 |
121 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.77078045 |
122 | mitotic chromosome condensation (GO:0007076) | 2.76804108 |
123 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.76549563 |
124 | UTP metabolic process (GO:0046051) | 2.76351382 |
125 | RNA capping (GO:0036260) | 2.76136246 |
126 | 7-methylguanosine RNA capping (GO:0009452) | 2.76136246 |
127 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 2.76070757 |
128 | deoxyribose phosphate biosynthetic process (GO:0046385) | 2.76070757 |
129 | negative regulation of mRNA metabolic process (GO:1903312) | 2.75986394 |
130 | peptidyl-arginine N-methylation (GO:0035246) | 2.75853951 |
131 | peptidyl-arginine methylation (GO:0018216) | 2.75853951 |
132 | CTP metabolic process (GO:0046036) | 2.75603467 |
133 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 2.74553405 |
134 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.74265965 |
135 | negative regulation of ligase activity (GO:0051352) | 2.74205321 |
136 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.74205321 |
137 | pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130) | 2.74026513 |
138 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.73930380 |
139 | termination of RNA polymerase II transcription (GO:0006369) | 2.73716079 |
140 | mRNA splicing, via spliceosome (GO:0000398) | 2.71252124 |
Rank | Gene Set | Z-score |
---|---|---|
1 | E2F7_22180533_ChIP-Seq_HELA_Human | 6.90348413 |
2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.89963772 |
3 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 4.35521483 |
4 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.40905113 |
5 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.26234797 |
6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.11753639 |
7 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.09695771 |
8 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.08214970 |
9 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 3.02866064 |
10 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.98752113 |
11 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.89977602 |
12 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.83369297 |
13 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.75182548 |
14 | * XRN2_22483619_ChIP-Seq_HELA_Human | 2.59727517 |
15 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.56671376 |
16 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.38422598 |
17 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.34093777 |
18 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.28308004 |
19 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.26864547 |
20 | MYC_22102868_ChIP-Seq_BL_Human | 2.20093825 |
21 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.18009232 |
22 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.14458192 |
23 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 2.13942670 |
24 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.13429128 |
25 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.12640974 |
26 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.11788834 |
27 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.07378375 |
28 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.07368725 |
29 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.06929580 |
30 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.05408307 |
31 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.02585939 |
32 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.02275947 |
33 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.01874814 |
34 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.01395809 |
35 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.96170653 |
36 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.84657013 |
37 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.81845163 |
38 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.81107079 |
39 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.80757414 |
40 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.79892045 |
41 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.72282769 |
42 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.70413340 |
43 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.70367427 |
44 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.69279459 |
45 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.65048534 |
46 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.62457311 |
47 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.62159222 |
48 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.60267884 |
49 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.60119169 |
50 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.59689260 |
51 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.59478094 |
52 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.47352165 |
53 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.45288001 |
54 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.44235208 |
55 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.43604744 |
56 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.42144890 |
57 | * YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.41932766 |
58 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.41467159 |
59 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.41078640 |
60 | * NCOR1_26117541_ChIP-Seq_K562_Human | 1.39254901 |
61 | * TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.35885788 |
62 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.35532960 |
63 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.33373788 |
64 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.32256063 |
65 | * KDM5A_27292631_Chip-Seq_BREAST_Human | 1.32181934 |
66 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.30799717 |
67 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.29461028 |
68 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.28784665 |
69 | P68_20966046_ChIP-Seq_HELA_Human | 1.27354471 |
70 | * KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.27118458 |
71 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.26968523 |
72 | * SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.25179407 |
73 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.24744553 |
74 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.24161683 |
75 | MAF_26560356_Chip-Seq_TH2_Human | 1.22933993 |
76 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.22024690 |
77 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.21300207 |
78 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.19433974 |
79 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.17942906 |
80 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.16157656 |
81 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.15208764 |
82 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.14752395 |
83 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.14363912 |
84 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.14111642 |
85 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.14030939 |
86 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.12342765 |
87 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.12310274 |
88 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.12171227 |
89 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.12060011 |
90 | MAF_26560356_Chip-Seq_TH1_Human | 1.11785720 |
91 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.11153735 |
92 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.11088395 |
93 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.10309681 |
94 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.10019458 |
95 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.09978094 |
96 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.08600593 |
97 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.08207384 |
98 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.08182803 |
99 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.07423739 |
100 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.07290576 |
101 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.07062737 |
102 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.06575679 |
103 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.04729089 |
104 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.04692621 |
105 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.03157560 |
106 | UTX_26944678_Chip-Seq_JUKART_Human | 1.02270200 |
107 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.01232373 |
108 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.00931086 |
109 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 1.00521843 |
110 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.00458069 |
111 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.99055812 |
112 | SCL_19346495_ChIP-Seq_HPC-7_Human | 0.98869348 |
113 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.98416084 |
114 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 0.98185889 |
115 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.94352189 |
116 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.94069811 |
117 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.92397143 |
118 | * FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.91690128 |
119 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.90638395 |
120 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.88510744 |
121 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.87562021 |
122 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.86401858 |
123 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.86199012 |
124 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.83418684 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0003693_abnormal_embryo_hatching | 5.43613159 |
2 | MP0004957_abnormal_blastocyst_morpholog | 4.06087335 |
3 | MP0010094_abnormal_chromosome_stability | 3.86735189 |
4 | MP0003111_abnormal_nucleus_morphology | 3.72446074 |
5 | MP0002396_abnormal_hematopoietic_system | 3.60950423 |
6 | MP0003077_abnormal_cell_cycle | 3.33326328 |
7 | MP0008058_abnormal_DNA_repair | 3.25492323 |
8 | MP0005451_abnormal_body_composition | 3.09287136 |
9 | MP0003806_abnormal_nucleotide_metabolis | 2.97290699 |
10 | MP0008057_abnormal_DNA_replication | 2.89998022 |
11 | MP0000490_abnormal_crypts_of | 2.71976991 |
12 | MP0000678_abnormal_parathyroid_gland | 2.70642651 |
13 | MP0008007_abnormal_cellular_replicative | 2.34192344 |
14 | MP0005174_abnormal_tail_pigmentation | 2.32409530 |
15 | MP0009379_abnormal_foot_pigmentation | 2.27818658 |
16 | MP0003123_paternal_imprinting | 2.16113106 |
17 | MP0008932_abnormal_embryonic_tissue | 1.93982161 |
18 | MP0000350_abnormal_cell_proliferation | 1.93751901 |
19 | MP0009278_abnormal_bone_marrow | 1.90213797 |
20 | MP0009697_abnormal_copulation | 1.88508884 |
21 | MP0001730_embryonic_growth_arrest | 1.88467795 |
22 | MP0010352_gastrointestinal_tract_polyps | 1.83670687 |
23 | MP0005058_abnormal_lysosome_morphology | 1.82343509 |
24 | MP0009333_abnormal_splenocyte_physiolog | 1.80970391 |
25 | MP0004808_abnormal_hematopoietic_stem | 1.79222471 |
26 | MP0003186_abnormal_redox_activity | 1.71244802 |
27 | MP0008995_early_reproductive_senescence | 1.71054240 |
28 | MP0004147_increased_porphyrin_level | 1.70330048 |
29 | MP0003786_premature_aging | 1.70128196 |
30 | MP0003866_abnormal_defecation | 1.64515215 |
31 | MP0001545_abnormal_hematopoietic_system | 1.60027268 |
32 | MP0005397_hematopoietic_system_phenotyp | 1.60027268 |
33 | MP0003763_abnormal_thymus_physiology | 1.52610854 |
34 | MP0006292_abnormal_olfactory_placode | 1.52061383 |
35 | MP0002398_abnormal_bone_marrow | 1.50820257 |
36 | MP0000313_abnormal_cell_death | 1.49483373 |
37 | MP0003121_genomic_imprinting | 1.45873291 |
38 | MP0000358_abnormal_cell_content/ | 1.45690105 |
39 | MP0002019_abnormal_tumor_incidence | 1.43776034 |
40 | MP0004233_abnormal_muscle_weight | 1.42315030 |
41 | MP0004185_abnormal_adipocyte_glucose | 1.39776359 |
42 | MP0000681_abnormal_thyroid_gland | 1.39421130 |
43 | MP0005083_abnormal_biliary_tract | 1.38372588 |
44 | MP0005423_abnormal_somatic_nervous | 1.37637721 |
45 | MP0002095_abnormal_skin_pigmentation | 1.36742431 |
46 | MP0010307_abnormal_tumor_latency | 1.36334474 |
47 | MP0001873_stomach_inflammation | 1.36211872 |
48 | MP0002080_prenatal_lethality | 1.36161256 |
49 | MP0005501_abnormal_skin_physiology | 1.35027626 |
50 | MP0005075_abnormal_melanosome_morpholog | 1.34499017 |
51 | MP0000015_abnormal_ear_pigmentation | 1.34262742 |
52 | MP0002877_abnormal_melanocyte_morpholog | 1.33881480 |
53 | MP0000703_abnormal_thymus_morphology | 1.33673000 |
54 | MP0002249_abnormal_larynx_morphology | 1.32998580 |
55 | MP0002638_abnormal_pupillary_reflex | 1.32444994 |
56 | MP0001661_extended_life_span | 1.31078911 |
57 | MP0001348_abnormal_lacrimal_gland | 1.30308200 |
58 | MP0002722_abnormal_immune_system | 1.30055930 |
59 | MP0006035_abnormal_mitochondrial_morpho | 1.29737683 |
60 | MP0008877_abnormal_DNA_methylation | 1.28248697 |
61 | MP0001697_abnormal_embryo_size | 1.22136072 |
62 | MP0000689_abnormal_spleen_morphology | 1.19175485 |
63 | MP0001986_abnormal_taste_sensitivity | 1.19057213 |
64 | MP0001529_abnormal_vocalization | 1.18600418 |
65 | MP0001188_hyperpigmentation | 1.17763381 |
66 | MP0003567_abnormal_fetal_cardiomyocyte | 1.17386759 |
67 | MP0000465_gastrointestinal_hemorrhage | 1.14744043 |
68 | MP0002163_abnormal_gland_morphology | 1.11887359 |
69 | MP0002429_abnormal_blood_cell | 1.11076815 |
70 | MP0003656_abnormal_erythrocyte_physiolo | 1.10873818 |
71 | MP0006036_abnormal_mitochondrial_physio | 1.08168426 |
72 | MP0008260_abnormal_autophagy | 1.07993285 |
73 | MP0002751_abnormal_autonomic_nervous | 1.04254999 |
74 | MP0002210_abnormal_sex_determination | 1.02637715 |
75 | MP0002160_abnormal_reproductive_system | 1.02592647 |
76 | MP0001853_heart_inflammation | 1.02082941 |
77 | MP0000716_abnormal_immune_system | 1.01991401 |
78 | MP0000477_abnormal_intestine_morphology | 1.01819744 |
79 | MP0006276_abnormal_autonomic_nervous | 1.01755403 |
80 | MP0010155_abnormal_intestine_physiology | 0.98597270 |
81 | MP0001929_abnormal_gametogenesis | 0.97878805 |
82 | MP0001727_abnormal_embryo_implantation | 0.97478776 |
83 | MP0001881_abnormal_mammary_gland | 0.96542400 |
84 | MP0003436_decreased_susceptibility_to | 0.96086974 |
85 | MP0004859_abnormal_synaptic_plasticity | 0.95836440 |
86 | MP0001672_abnormal_embryogenesis/_devel | 0.95827920 |
87 | MP0005380_embryogenesis_phenotype | 0.95827920 |
88 | MP0001764_abnormal_homeostasis | 0.95815830 |
89 | MP0001145_abnormal_male_reproductive | 0.95534930 |
90 | MP0002085_abnormal_embryonic_tissue | 0.94820075 |
91 | MP0002234_abnormal_pharynx_morphology | 0.91358659 |
92 | MP0008770_decreased_survivor_rate | 0.90899167 |
93 | MP0003119_abnormal_digestive_system | 0.90577978 |
94 | MP0001346_abnormal_lacrimal_gland | 0.90575749 |
95 | MP0001663_abnormal_digestive_system | 0.89574723 |
96 | MP0000858_altered_metastatic_potential | 0.88011745 |
97 | MP0003879_abnormal_hair_cell | 0.87314286 |
98 | MP0005645_abnormal_hypothalamus_physiol | 0.87181164 |
99 | MP0002084_abnormal_developmental_patter | 0.86622519 |
100 | MP0002420_abnormal_adaptive_immunity | 0.85288325 |
101 | MP0004858_abnormal_nervous_system | 0.85035733 |
102 | MP0001905_abnormal_dopamine_level | 0.84824004 |
103 | MP0002132_abnormal_respiratory_system | 0.83972938 |
104 | MP0001819_abnormal_immune_cell | 0.83059588 |
105 | MP0005025_abnormal_response_to | 0.83014336 |
106 | MP0009931_abnormal_skin_appearance | 0.82474903 |
107 | MP0008872_abnormal_physiological_respon | 0.79446641 |
108 | MP0004133_heterotaxia | 0.79347163 |
109 | MP0005384_cellular_phenotype | 0.78999668 |
110 | MP0003698_abnormal_male_reproductive | 0.78996392 |
111 | MP0003984_embryonic_growth_retardation | 0.78461809 |
112 | MP0000653_abnormal_sex_gland | 0.77850045 |
113 | MP0001968_abnormal_touch/_nociception | 0.77221732 |
114 | MP0004811_abnormal_neuron_physiology | 0.76641728 |
115 | MP0005000_abnormal_immune_tolerance | 0.76443535 |
116 | MP0000003_abnormal_adipose_tissue | 0.76427918 |
117 | MP0005076_abnormal_cell_differentiation | 0.76006102 |
118 | MP0000569_abnormal_digit_pigmentation | 0.75483914 |
119 | MP0002088_abnormal_embryonic_growth/wei | 0.75406096 |
120 | MP0002086_abnormal_extraembryonic_tissu | 0.75184600 |
121 | MP0003315_abnormal_perineum_morphology | 0.75058567 |
122 | MP0005671_abnormal_response_to | 0.74758531 |
123 | MP0002822_catalepsy | 0.74002969 |
124 | MP0000372_irregular_coat_pigmentation | 0.73054142 |
125 | MP0002148_abnormal_hypersensitivity_rea | 0.71712902 |
126 | MP0002452_abnormal_antigen_presenting | 0.71356819 |
127 | MP0003221_abnormal_cardiomyocyte_apopto | 0.71211290 |
128 | MP0002796_impaired_skin_barrier | 0.70939939 |
129 | MP0000685_abnormal_immune_system | 0.70788888 |
130 | MP0000537_abnormal_urethra_morphology | 0.69938518 |
131 | MP0000598_abnormal_liver_morphology | 0.68613591 |
132 | MP0002970_abnormal_white_adipose | 0.68470376 |
133 | MP0001800_abnormal_humoral_immune | 0.68088237 |
134 | MP0002723_abnormal_immune_serum | 0.67569469 |
135 | MP0001835_abnormal_antigen_presentation | 0.67206419 |
136 | MP0004197_abnormal_fetal_growth/weight/ | 0.66741438 |
137 | MP0003718_maternal_effect | 0.66614103 |
138 | MP0001293_anophthalmia | 0.66104499 |
139 | MP0003172_abnormal_lysosome_physiology | 0.65430229 |
140 | MP0005636_abnormal_mineral_homeostasis | 0.64758444 |
141 | MP0005464_abnormal_platelet_physiology | 0.63647915 |
142 | MP0005621_abnormal_cell_physiology | 0.63364818 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 7.28532830 |
2 | Abnormal number of erythroid precursors (HP:0012131) | 6.89710031 |
3 | Reticulocytopenia (HP:0001896) | 5.72415551 |
4 | Aplastic anemia (HP:0001915) | 4.54019195 |
5 | Truncus arteriosus (HP:0001660) | 4.45517040 |
6 | Pallor (HP:0000980) | 4.21194775 |
7 | Hyperthyroidism (HP:0000836) | 4.16764599 |
8 | Hypertensive crisis (HP:0100735) | 4.04872504 |
9 | Macrocytic anemia (HP:0001972) | 3.98881715 |
10 | Birth length less than 3rd percentile (HP:0003561) | 3.94738221 |
11 | Microvesicular hepatic steatosis (HP:0001414) | 3.94121930 |
12 | Colon cancer (HP:0003003) | 3.73863697 |
13 | Seborrheic dermatitis (HP:0001051) | 3.57621437 |
14 | Oral leukoplakia (HP:0002745) | 3.54197293 |
15 | Cholecystitis (HP:0001082) | 3.47968866 |
16 | Abnormal gallbladder physiology (HP:0012438) | 3.47968866 |
17 | Thrombocytosis (HP:0001894) | 3.41687286 |
18 | Ragged-red muscle fibers (HP:0003200) | 3.31844585 |
19 | Microretrognathia (HP:0000308) | 3.18180924 |
20 | Reticulocytosis (HP:0001923) | 3.07399037 |
21 | Increased muscle lipid content (HP:0009058) | 3.06077041 |
22 | Absent thumb (HP:0009777) | 2.96669032 |
23 | Selective tooth agenesis (HP:0001592) | 2.85007077 |
24 | Obstructive lung disease (HP:0006536) | 2.83031918 |
25 | Chronic obstructive pulmonary disease (HP:0006510) | 2.83031918 |
26 | Acute encephalopathy (HP:0006846) | 2.79449301 |
27 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.78935287 |
28 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.78935287 |
29 | Type I transferrin isoform profile (HP:0003642) | 2.72816045 |
30 | Abnormality of the anterior horn cell (HP:0006802) | 2.67017869 |
31 | Degeneration of anterior horn cells (HP:0002398) | 2.67017869 |
32 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 2.64147777 |
33 | Abnormality of the tricuspid valve (HP:0001702) | 2.61660260 |
34 | Cerebral hypomyelination (HP:0006808) | 2.61346339 |
35 | Hypoparathyroidism (HP:0000829) | 2.61184079 |
36 | Increased serum lactate (HP:0002151) | 2.57352911 |
37 | Rough bone trabeculation (HP:0100670) | 2.56140386 |
38 | Myelodysplasia (HP:0002863) | 2.54704893 |
39 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.51901420 |
40 | Hepatocellular necrosis (HP:0001404) | 2.51237940 |
41 | Testicular atrophy (HP:0000029) | 2.47569186 |
42 | Breast hypoplasia (HP:0003187) | 2.47155495 |
43 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.46490391 |
44 | Acute lymphatic leukemia (HP:0006721) | 2.45684109 |
45 | Abnormality of glycolysis (HP:0004366) | 2.44571903 |
46 | Abnormality of the preputium (HP:0100587) | 2.44241142 |
47 | Petechiae (HP:0000967) | 2.43112461 |
48 | Progressive muscle weakness (HP:0003323) | 2.42095198 |
49 | 11 pairs of ribs (HP:0000878) | 2.41065758 |
50 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.40802446 |
51 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 2.40543944 |
52 | Lactic acidosis (HP:0003128) | 2.39845070 |
53 | IgM deficiency (HP:0002850) | 2.37814849 |
54 | Increased hepatocellular lipid droplets (HP:0006565) | 2.34861472 |
55 | Pancytopenia (HP:0001876) | 2.32801659 |
56 | Broad distal phalanx of finger (HP:0009836) | 2.32330465 |
57 | Medulloblastoma (HP:0002885) | 2.30844531 |
58 | Premature graying of hair (HP:0002216) | 2.29091939 |
59 | Basal cell carcinoma (HP:0002671) | 2.28093914 |
60 | Abnormality of DNA repair (HP:0003254) | 2.27395363 |
61 | Abnormality of T cell physiology (HP:0011840) | 2.25688347 |
62 | Septate vagina (HP:0001153) | 2.24626869 |
63 | Asplenia (HP:0001746) | 2.24229250 |
64 | Exercise intolerance (HP:0003546) | 2.24024430 |
65 | Progressive microcephaly (HP:0000253) | 2.22647656 |
66 | Patellar aplasia (HP:0006443) | 2.22550266 |
67 | Mitochondrial inheritance (HP:0001427) | 2.22350328 |
68 | Nonimmune hydrops fetalis (HP:0001790) | 2.22022354 |
69 | Chromsome breakage (HP:0040012) | 2.20983429 |
70 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.20383147 |
71 | Increased CSF lactate (HP:0002490) | 2.18135175 |
72 | Ependymoma (HP:0002888) | 2.16795861 |
73 | Self-mutilation (HP:0000742) | 2.14313428 |
74 | Abnormality of reticulocytes (HP:0004312) | 2.14302202 |
75 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.12818142 |
76 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.12818142 |
77 | Abnormal protein glycosylation (HP:0012346) | 2.12818142 |
78 | Abnormal glycosylation (HP:0012345) | 2.12818142 |
79 | Cerebral edema (HP:0002181) | 2.12225921 |
80 | Cholelithiasis (HP:0001081) | 2.11580430 |
81 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.11295672 |
82 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.10500379 |
83 | Optic nerve coloboma (HP:0000588) | 2.10308575 |
84 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.09267490 |
85 | Atelectasis (HP:0100750) | 2.08993369 |
86 | Abnormal large intestine physiology (HP:0012700) | 2.08899413 |
87 | Agnosia (HP:0010524) | 2.07823993 |
88 | Reduced antithrombin III activity (HP:0001976) | 2.07808353 |
89 | Increased serum pyruvate (HP:0003542) | 2.07676195 |
90 | Emotional lability (HP:0000712) | 2.07338939 |
91 | Cellular immunodeficiency (HP:0005374) | 2.06280806 |
92 | Bone marrow hypocellularity (HP:0005528) | 2.06060780 |
93 | Papilledema (HP:0001085) | 2.05667336 |
94 | Abnormality of chromosome stability (HP:0003220) | 2.05499185 |
95 | Neoplasm of the pancreas (HP:0002894) | 2.05118963 |
96 | Horseshoe kidney (HP:0000085) | 2.04718365 |
97 | Abnormal number of incisors (HP:0011064) | 2.04598961 |
98 | Tinnitus (HP:0000360) | 2.03784899 |
99 | Hypoplasia of the pons (HP:0012110) | 2.02795856 |
100 | Progressive macrocephaly (HP:0004481) | 2.02297458 |
101 | Increased serum ferritin (HP:0003281) | 1.99840422 |
102 | Unsteady gait (HP:0002317) | 1.98912814 |
103 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 1.98651477 |
104 | Bowel incontinence (HP:0002607) | 1.97672820 |
105 | Amyotrophic lateral sclerosis (HP:0007354) | 1.96588680 |
106 | Poor suck (HP:0002033) | 1.94023388 |
107 | Abnormality of the labia minora (HP:0012880) | 1.92712647 |
108 | Poikiloderma (HP:0001029) | 1.92161460 |
109 | Muscle fiber atrophy (HP:0100295) | 1.91372058 |
110 | Short middle phalanx of the 5th finger (HP:0004220) | 1.91368751 |
111 | Increased intramyocellular lipid droplets (HP:0012240) | 1.90651767 |
112 | Premature ovarian failure (HP:0008209) | 1.90390277 |
113 | Respiratory difficulties (HP:0002880) | 1.89903091 |
114 | Panhypogammaglobulinemia (HP:0003139) | 1.89606535 |
115 | Pulmonary fibrosis (HP:0002206) | 1.89190591 |
116 | Hypergonadotropic hypogonadism (HP:0000815) | 1.88518424 |
117 | Elevated erythrocyte sedimentation rate (HP:0003565) | 1.88510575 |
118 | Meckel diverticulum (HP:0002245) | 1.88138900 |
119 | Lymphoma (HP:0002665) | 1.86607972 |
120 | Patellar dislocation (HP:0002999) | 1.84155503 |
121 | Abnormal trabecular bone morphology (HP:0100671) | 1.83713306 |
122 | Lipid accumulation in hepatocytes (HP:0006561) | 1.83664550 |
123 | Tracheoesophageal fistula (HP:0002575) | 1.83200087 |
124 | Severe visual impairment (HP:0001141) | 1.81646077 |
125 | Hepatic necrosis (HP:0002605) | 1.81440118 |
126 | Exertional dyspnea (HP:0002875) | 1.81372125 |
127 | Thick lower lip vermilion (HP:0000179) | 1.80177161 |
128 | Carpal bone hypoplasia (HP:0001498) | 1.79826199 |
129 | Amaurosis fugax (HP:0100576) | 1.79462339 |
130 | Squamous cell carcinoma (HP:0002860) | 1.79225394 |
131 | Redundant skin (HP:0001582) | 1.79181013 |
132 | Agammaglobulinemia (HP:0004432) | 1.79129778 |
133 | Abnormality of the gallbladder (HP:0005264) | 1.78844419 |
134 | Acute necrotizing encephalopathy (HP:0006965) | 1.78695945 |
135 | Abnormally folded helix (HP:0008544) | 1.78561532 |
136 | Death in infancy (HP:0001522) | 1.78112405 |
137 | Multiple enchondromatosis (HP:0005701) | 1.77692190 |
138 | Depressed nasal ridge (HP:0000457) | 1.77637865 |
139 | Abnormality of the thymus (HP:0000777) | 1.77539862 |
140 | Abnormality of the ileum (HP:0001549) | 1.77459725 |
141 | Trismus (HP:0000211) | 1.76945619 |
142 | Aplasia/Hypoplasia of the earlobes (HP:0009906) | 1.76206464 |
143 | Secondary amenorrhea (HP:0000869) | 1.76206018 |
144 | 3-Methylglutaconic aciduria (HP:0003535) | 1.76038851 |
145 | Chronic otitis media (HP:0000389) | 1.75771966 |
146 | Abnormal mitochondria in muscle tissue (HP:0008316) | 1.75531284 |
147 | Myopathic facies (HP:0002058) | 1.74145975 |
148 | Hypoplasia of the radius (HP:0002984) | 1.73479394 |
149 | Missing ribs (HP:0000921) | 1.72860468 |
150 | Abnormality of cochlea (HP:0000375) | 1.72063907 |
151 | Lissencephaly (HP:0001339) | 1.71949569 |
152 | Cortical visual impairment (HP:0100704) | 1.71135274 |
153 | Abnormal gallbladder morphology (HP:0012437) | 1.70586037 |
Rank | Gene Set | Z-score |
---|---|---|
1 | WEE1 | 3.61250518 |
2 | NME2 | 3.60438441 |
3 | BUB1 | 3.50283625 |
4 | IRAK3 | 3.15213079 |
5 | BCKDK | 3.11484557 |
6 | CDC7 | 2.72866514 |
7 | SMG1 | 2.58849833 |
8 | PIM2 | 2.53013336 |
9 | VRK2 | 2.42952682 |
10 | STK16 | 2.41943431 |
11 | SCYL2 | 2.33025135 |
12 | TRIB3 | 2.31136679 |
13 | EIF2AK1 | 2.24108828 |
14 | EEF2K | 2.16914922 |
15 | ACVR1B | 2.11590472 |
16 | TESK2 | 2.10191229 |
17 | NEK2 | 2.07796042 |
18 | RPS6KB2 | 1.95784981 |
19 | FLT3 | 1.93118841 |
20 | DYRK3 | 1.91999526 |
21 | VRK1 | 1.90312933 |
22 | MAP3K11 | 1.86133187 |
23 | ERN1 | 1.80526567 |
24 | NME1 | 1.79560020 |
25 | TLK1 | 1.74864516 |
26 | STK4 | 1.54466253 |
27 | TSSK6 | 1.53965335 |
28 | CDK19 | 1.51826515 |
29 | PRPF4B | 1.48012755 |
30 | PASK | 1.46095763 |
31 | ZAK | 1.45057931 |
32 | CCNB1 | 1.44727706 |
33 | CDK7 | 1.44629492 |
34 | MAP4K1 | 1.42845783 |
35 | EIF2AK3 | 1.36690965 |
36 | MAP3K12 | 1.30716538 |
37 | SRPK1 | 1.30500117 |
38 | ARAF | 1.30353681 |
39 | NEK1 | 1.28853506 |
40 | BRAF | 1.25772806 |
41 | RIPK4 | 1.25196423 |
42 | BRSK1 | 1.24827063 |
43 | KIT | 1.23442399 |
44 | MAP3K9 | 1.22934990 |
45 | AURKA | 1.22540104 |
46 | ATR | 1.20761473 |
47 | TEC | 1.19492670 |
48 | PLK1 | 1.18399223 |
49 | PKN2 | 1.18086866 |
50 | IRAK4 | 1.17825922 |
51 | RPS6KA4 | 1.15797982 |
52 | TESK1 | 1.15361690 |
53 | TAOK2 | 1.12435390 |
54 | TGFBR1 | 1.10403971 |
55 | RAF1 | 1.08844889 |
56 | MKNK1 | 1.08695458 |
57 | PBK | 1.08670805 |
58 | DAPK1 | 1.07555989 |
59 | BRSK2 | 1.04902140 |
60 | TNIK | 1.03589224 |
61 | CDK12 | 1.02600975 |
62 | MAP2K3 | 1.01180137 |
63 | MARK1 | 0.97271314 |
64 | MAP3K8 | 0.96649479 |
65 | MAPKAPK3 | 0.96096373 |
66 | BLK | 0.95314350 |
67 | MAP3K1 | 0.94549498 |
68 | MAPK11 | 0.93370666 |
69 | CLK1 | 0.92649891 |
70 | AURKB | 0.92196992 |
71 | DYRK2 | 0.91963849 |
72 | TTK | 0.91705831 |
73 | CHEK2 | 0.89610085 |
74 | ZAP70 | 0.87792503 |
75 | BTK | 0.86853269 |
76 | MINK1 | 0.86555432 |
77 | PLK4 | 0.86525792 |
78 | ICK | 0.86120140 |
79 | GRK6 | 0.85943817 |
80 | TBK1 | 0.82329262 |
81 | SYK | 0.81158971 |
82 | EPHA2 | 0.78385189 |
83 | TAOK1 | 0.77508749 |
84 | TNK2 | 0.76990651 |
85 | SIK1 | 0.76978651 |
86 | ALK | 0.75341023 |
87 | LRRK2 | 0.73491414 |
88 | MKNK2 | 0.73198013 |
89 | ABL2 | 0.73074138 |
90 | CSNK2A2 | 0.72700797 |
91 | KSR2 | 0.71884796 |
92 | PRKCI | 0.70960412 |
93 | MAP3K6 | 0.69761278 |
94 | IRAK2 | 0.69624421 |
95 | CDK4 | 0.67750228 |
96 | PIM1 | 0.66451669 |
97 | CHEK1 | 0.64951817 |
98 | TAOK3 | 0.64911474 |
99 | PAK1 | 0.64864083 |
100 | PLK3 | 0.64715002 |
101 | PAK4 | 0.64616759 |
102 | AKT2 | 0.60132667 |
103 | CDK8 | 0.58747619 |
104 | IKBKB | 0.58327914 |
105 | ILK | 0.56784566 |
106 | CDK2 | 0.54831191 |
107 | MAP2K6 | 0.52971615 |
108 | RPS6KA5 | 0.52603981 |
109 | JAK3 | 0.48867832 |
110 | CSNK2A1 | 0.48713732 |
111 | MAP3K10 | 0.48595566 |
112 | DAPK3 | 0.48093695 |
113 | CAMKK2 | 0.47040449 |
114 | NUAK1 | 0.47032079 |
115 | MAP3K3 | 0.46566669 |
116 | CSNK1G3 | 0.46214472 |
117 | CSF1R | 0.44914678 |
118 | MTOR | 0.43217362 |
119 | PNCK | 0.42823652 |
120 | CDK1 | 0.42658157 |
121 | STK10 | 0.41837792 |
122 | MAP3K5 | 0.41759810 |
123 | EIF2AK2 | 0.40792206 |
124 | TYK2 | 0.40526470 |
125 | MAP3K13 | 0.40032259 |
126 | FES | 0.39966951 |
127 | KDR | 0.39412273 |
128 | CAMK1 | 0.38625432 |
129 | ATM | 0.36639972 |
130 | CDK11A | 0.36283399 |
131 | PDK2 | 0.35107731 |
132 | MATK | 0.35008495 |
133 | SIK2 | 0.34737205 |
134 | MAP2K2 | 0.34684989 |
135 | BMX | 0.34575059 |
136 | MAPKAPK2 | 0.34125018 |
137 | MST1R | 0.32512155 |
138 | MAP3K2 | 0.29891685 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Ribosome_Homo sapiens_hsa03010 | 5.02317360 |
2 | DNA replication_Homo sapiens_hsa03030 | 4.68852658 |
3 | Mismatch repair_Homo sapiens_hsa03430 | 3.65801071 |
4 | RNA polymerase_Homo sapiens_hsa03020 | 3.55985652 |
5 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.40239678 |
6 | Proteasome_Homo sapiens_hsa03050 | 3.22368261 |
7 | Spliceosome_Homo sapiens_hsa03040 | 3.06391971 |
8 | Base excision repair_Homo sapiens_hsa03410 | 2.83263859 |
9 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.78679852 |
10 | RNA transport_Homo sapiens_hsa03013 | 2.65879606 |
11 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.43562807 |
12 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.32648459 |
13 | Homologous recombination_Homo sapiens_hsa03440 | 2.27203186 |
14 | Cell cycle_Homo sapiens_hsa04110 | 1.88165765 |
15 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.74033277 |
16 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.73687503 |
17 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.72409181 |
18 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.65541415 |
19 | RNA degradation_Homo sapiens_hsa03018 | 1.58768377 |
20 | Purine metabolism_Homo sapiens_hsa00230 | 1.49330151 |
21 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.45476796 |
22 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.41984728 |
23 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.39480396 |
24 | Basal transcription factors_Homo sapiens_hsa03022 | 1.37409264 |
25 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.33844195 |
26 | Carbon metabolism_Homo sapiens_hsa01200 | 1.31542319 |
27 | Sulfur relay system_Homo sapiens_hsa04122 | 1.29721027 |
28 | Parkinsons disease_Homo sapiens_hsa05012 | 1.29371861 |
29 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.22168763 |
30 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.17282379 |
31 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.15697897 |
32 | Huntingtons disease_Homo sapiens_hsa05016 | 1.14883051 |
33 | Thyroid cancer_Homo sapiens_hsa05216 | 1.14147813 |
34 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 1.11483643 |
35 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.06474034 |
36 | Other glycan degradation_Homo sapiens_hsa00511 | 1.06078043 |
37 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.04085302 |
38 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.02555047 |
39 | Protein export_Homo sapiens_hsa03060 | 1.00040306 |
40 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.99982514 |
41 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.96567626 |
42 | Alcoholism_Homo sapiens_hsa05034 | 0.93263803 |
43 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.91823334 |
44 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.90456489 |
45 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.89304093 |
46 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.89019845 |
47 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.86819094 |
48 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.80790387 |
49 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.76601456 |
50 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.75972139 |
51 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.73728476 |
52 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.73670330 |
53 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.72127066 |
54 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.71905973 |
55 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.71533033 |
56 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.69820894 |
57 | Galactose metabolism_Homo sapiens_hsa00052 | 0.66102874 |
58 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.64528352 |
59 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.63315755 |
60 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.59610362 |
61 | Alzheimers disease_Homo sapiens_hsa05010 | 0.58258833 |
62 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.58053127 |
63 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.56085210 |
64 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.55161780 |
65 | Colorectal cancer_Homo sapiens_hsa05210 | 0.54574680 |
66 | Shigellosis_Homo sapiens_hsa05131 | 0.54529137 |
67 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.52827868 |
68 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.49541374 |
69 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.47338907 |
70 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.46906663 |
71 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.46833313 |
72 | Apoptosis_Homo sapiens_hsa04210 | 0.44966819 |
73 | HTLV-I infection_Homo sapiens_hsa05166 | 0.44882196 |
74 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.43534563 |
75 | Legionellosis_Homo sapiens_hsa05134 | 0.42536954 |
76 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.42286993 |
77 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.41886257 |
78 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.41872092 |
79 | Hepatitis B_Homo sapiens_hsa05161 | 0.41811296 |
80 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.40832364 |
81 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.40808799 |
82 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.39267745 |
83 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.38892489 |
84 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.38884895 |
85 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.38520238 |
86 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.38302994 |
87 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.38096550 |
88 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.37444934 |
89 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.37153409 |
90 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.35910615 |
91 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.35829176 |
92 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.35656764 |
93 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.34434621 |
94 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.33320263 |
95 | Bladder cancer_Homo sapiens_hsa05219 | 0.28499065 |
96 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.27556569 |
97 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.27399179 |
98 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.27289047 |
99 | Measles_Homo sapiens_hsa05162 | 0.27213009 |
100 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.25303172 |
101 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.25257239 |
102 | Long-term potentiation_Homo sapiens_hsa04720 | 0.24407675 |
103 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.24354934 |
104 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.24209394 |
105 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.22057233 |
106 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.20436646 |
107 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.20148530 |
108 | Endometrial cancer_Homo sapiens_hsa05213 | 0.20052885 |
109 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.19868779 |
110 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.19683699 |
111 | Influenza A_Homo sapiens_hsa05164 | 0.19645620 |
112 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.19559502 |
113 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.18735222 |
114 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.18436352 |
115 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.17945416 |
116 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.17502199 |
117 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.16789348 |
118 | Allograft rejection_Homo sapiens_hsa05330 | 0.16593303 |
119 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.15794564 |
120 | Gap junction_Homo sapiens_hsa04540 | 0.15391655 |
121 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.13080343 |
122 | Metabolic pathways_Homo sapiens_hsa01100 | 0.13017409 |
123 | Leishmaniasis_Homo sapiens_hsa05140 | 0.12712099 |
124 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.12011525 |
125 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.11781915 |