YEATS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: YEATS2 is a scaffolding subunit of the ADA2A (TADA2A; MIM 602276)-containing (ATAC) histone acetyltransferase complex (Wang et al., 2008 [PubMed 18838386]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.33362758
2DNA unwinding involved in DNA replication (GO:0006268)4.18485351
3paraxial mesoderm development (GO:0048339)3.73005078
4protein localization to kinetochore (GO:0034501)3.69300045
5pre-miRNA processing (GO:0031054)3.68682456
6nuclear pore complex assembly (GO:0051292)3.51201208
7nuclear pore organization (GO:0006999)3.51185135
8DNA topological change (GO:0006265)3.42907685
9mitotic sister chromatid cohesion (GO:0007064)3.36513903
10cytoplasmic mRNA processing body assembly (GO:0033962)3.35857123
11negative regulation of DNA repair (GO:0045738)3.35442559
12regulation of NFAT protein import into nucleus (GO:0051532)3.32656330
13regulation of nucleobase-containing compound transport (GO:0032239)3.32400637
14sister chromatid segregation (GO:0000819)3.22104096
15lateral sprouting from an epithelium (GO:0060601)3.22057462
16negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.18999682
17planar cell polarity pathway involved in neural tube closure (GO:0090179)3.14269962
18histone H3-K9 methylation (GO:0051567)3.13825142
19regulation of RNA export from nucleus (GO:0046831)3.07840100
20heterochromatin organization (GO:0070828)3.07760293
21mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.06979315
22outer ear morphogenesis (GO:0042473)3.05380042
23DNA geometric change (GO:0032392)3.04686189
24DNA duplex unwinding (GO:0032508)3.03673521
25convergent extension (GO:0060026)3.03198937
26regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.00426834
27regulation of sister chromatid cohesion (GO:0007063)2.99518546
28negative regulation of mRNA processing (GO:0050686)2.99089682
29kinetochore organization (GO:0051383)2.92468725
30mRNA splice site selection (GO:0006376)2.88709367
31mitotic chromosome condensation (GO:0007076)2.85406688
32protein localization to chromosome, centromeric region (GO:0071459)2.83770240
33mitotic sister chromatid segregation (GO:0000070)2.81558441
34neural tube development (GO:0021915)2.80623645
35negative regulation of RNA splicing (GO:0033119)2.80280501
36regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.77148256
37establishment of mitotic spindle localization (GO:0040001)2.76727435
38regulation of hippo signaling (GO:0035330)2.76696987
39negative regulation of histone methylation (GO:0031061)2.76414555
40stress granule assembly (GO:0034063)2.76296072
41regulation of posttranscriptional gene silencing (GO:0060147)2.75958318
42regulation of gene silencing by miRNA (GO:0060964)2.75958318
43regulation of gene silencing by RNA (GO:0060966)2.75958318
44embryonic foregut morphogenesis (GO:0048617)2.75597142
45regulation of histone H3-K9 methylation (GO:0051570)2.73660129
46morphogenesis of an epithelial sheet (GO:0002011)2.73539430
47regulation of spindle organization (GO:0090224)2.73094131
48positive regulation of gene expression, epigenetic (GO:0045815)2.72762097
49regulation of DNA damage checkpoint (GO:2000001)2.72536593
50cell migration in hindbrain (GO:0021535)2.71847105
51establishment of mitotic spindle orientation (GO:0000132)2.68826116
52histone H3-K4 trimethylation (GO:0080182)2.68557410
53regulation of DNA endoreduplication (GO:0032875)2.68493708
54NLS-bearing protein import into nucleus (GO:0006607)2.68232392
55regulation of histone H3-K27 methylation (GO:0061085)2.67806395
56pore complex assembly (GO:0046931)2.65921911
57alternative mRNA splicing, via spliceosome (GO:0000380)2.63947196
58positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.63936355
59DNA strand renaturation (GO:0000733)2.63331718
60polarized epithelial cell differentiation (GO:0030859)2.63110985
61protein-DNA complex disassembly (GO:0032986)2.62694721
62nucleosome disassembly (GO:0006337)2.62694721
63histone lysine demethylation (GO:0070076)2.61918516
64metaphase plate congression (GO:0051310)2.61247051
65head development (GO:0060322)2.60898938
66negative regulation of mRNA metabolic process (GO:1903312)2.60724887
67hippo signaling (GO:0035329)2.60442218
68lung-associated mesenchyme development (GO:0060484)2.59985225
69regulation of centriole replication (GO:0046599)2.59439183
70ATP-dependent chromatin remodeling (GO:0043044)2.59000768
71dosage compensation (GO:0007549)2.58339150
72semaphorin-plexin signaling pathway (GO:0071526)2.58202895
73monoubiquitinated protein deubiquitination (GO:0035520)2.56837716
74histone H3-K9 modification (GO:0061647)2.56681327
75establishment of nucleus localization (GO:0040023)2.56628046
76mitotic metaphase plate congression (GO:0007080)2.56171134
77chromatin assembly (GO:0031497)2.53933888
78histone demethylation (GO:0016577)2.53027783
79positive regulation of dendrite morphogenesis (GO:0050775)2.52918854
80histone H3-K36 demethylation (GO:0070544)2.52644443
81mesenchymal cell proliferation (GO:0010463)2.52021960
82DNA conformation change (GO:0071103)2.51634230
83corticosteroid receptor signaling pathway (GO:0031958)2.51018357
84positive regulation of chromosome segregation (GO:0051984)2.50389510
85somatic hypermutation of immunoglobulin genes (GO:0016446)2.49550211
86somatic diversification of immune receptors via somatic mutation (GO:0002566)2.49550211
87peptidyl-lysine trimethylation (GO:0018023)2.48774550
88regulation of mitotic spindle organization (GO:0060236)2.48531187
89notochord development (GO:0030903)2.46843475
90generation of neurons (GO:0048699)2.46583624
91regulation of translational fidelity (GO:0006450)2.46404853
92hindlimb morphogenesis (GO:0035137)2.45122864
93dorsal/ventral axis specification (GO:0009950)2.44787363
94mitotic nuclear envelope disassembly (GO:0007077)2.43417990
95DNA replication-independent nucleosome assembly (GO:0006336)2.43095262
96DNA replication-independent nucleosome organization (GO:0034724)2.43095262
97cochlea morphogenesis (GO:0090103)2.42889307
98neuron projection extension involved in neuron projection guidance (GO:1902284)2.42487652
99axon extension involved in axon guidance (GO:0048846)2.42487652
100glucocorticoid receptor signaling pathway (GO:0042921)2.41549448
101DNA replication initiation (GO:0006270)2.41413715
102embryonic hindlimb morphogenesis (GO:0035116)2.40792967
103establishment of spindle orientation (GO:0051294)2.40472137
104cell proliferation in forebrain (GO:0021846)2.40227769
105regulation of chromosome segregation (GO:0051983)2.40042257
106regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.40037923
107G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.38708254
108histone H3-K9 demethylation (GO:0033169)2.38645324
109regulation of cardioblast proliferation (GO:0003264)2.38550266
110regulation of secondary heart field cardioblast proliferation (GO:0003266)2.38550266
111spliceosomal tri-snRNP complex assembly (GO:0000244)2.38029759
112positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.37536222
113spindle assembly checkpoint (GO:0071173)2.37459637
114spindle checkpoint (GO:0031577)2.37373849
115chromatin assembly or disassembly (GO:0006333)2.37140669
116Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.36982286
117regulation of stem cell maintenance (GO:2000036)2.36940612
118hemidesmosome assembly (GO:0031581)2.36797807
119histone lysine methylation (GO:0034968)2.36637434
120peptidyl-lysine dimethylation (GO:0018027)2.36626169
121establishment of spindle localization (GO:0051293)2.35940673
122DNA replication-dependent nucleosome assembly (GO:0006335)2.35931120
123DNA replication-dependent nucleosome organization (GO:0034723)2.35931120
124positive regulation of cell cycle checkpoint (GO:1901978)2.35118804
125negative regulation of chromosome segregation (GO:0051985)2.35052316
126embryonic camera-type eye morphogenesis (GO:0048596)2.34101522
127cell proliferation involved in metanephros development (GO:0072203)2.33822661
128DNA damage induced protein phosphorylation (GO:0006975)2.33775514
129positive regulation of histone H3-K4 methylation (GO:0051571)2.32714619
130adherens junction assembly (GO:0034333)2.32430800
131bone trabecula formation (GO:0060346)2.32307903
132negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.32206333
133negative regulation of sister chromatid segregation (GO:0033046)2.32206333
134negative regulation of mitotic sister chromatid separation (GO:2000816)2.32206333
135negative regulation of mitotic sister chromatid segregation (GO:0033048)2.32206333
136mitotic spindle checkpoint (GO:0071174)2.32174005
137regulation of establishment of planar polarity (GO:0090175)2.31916368
138kinetochore assembly (GO:0051382)2.31510368
139coronary vasculature morphogenesis (GO:0060977)2.31421356
140positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.29655922
141positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.29655922
142positive regulation of mitotic sister chromatid separation (GO:1901970)2.29655922
143regulation of histone methylation (GO:0031060)2.27707825
144protein dealkylation (GO:0008214)2.26804378
145protein demethylation (GO:0006482)2.26804378
146establishment of apical/basal cell polarity (GO:0035089)2.24491439
147spinal cord development (GO:0021510)2.23896452
148peptidyl-threonine phosphorylation (GO:0018107)2.22140513
149somatic stem cell division (GO:0048103)2.21770289
150positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.19216762
151positive regulation of cell cycle G2/M phase transition (GO:1902751)2.19216762
152neuronal stem cell maintenance (GO:0097150)2.19099283
153layer formation in cerebral cortex (GO:0021819)2.18689685
154regulation of centrosome duplication (GO:0010824)2.18383353
155cytoskeletal anchoring at plasma membrane (GO:0007016)2.18316263
156peptidyl-threonine modification (GO:0018210)2.18146394
157eye morphogenesis (GO:0048592)2.17815333
158heart morphogenesis (GO:0003007)2.17390960
159positive regulation of dendritic spine morphogenesis (GO:0061003)2.17043444
160non-canonical Wnt signaling pathway (GO:0035567)2.16525668
161interkinetic nuclear migration (GO:0022027)2.16472821
162RNA stabilization (GO:0043489)2.16405590

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.66755610
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.06054416
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.69616037
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.48917210
5TP63_19390658_ChIP-ChIP_HaCaT_Human3.35762444
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.32247714
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.15336492
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.79494984
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.56553312
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.47514836
11HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.34834237
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.14249098
13AR_21909140_ChIP-Seq_LNCAP_Human2.11467262
14ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.09143097
15SOX2_18555785_ChIP-Seq_MESCs_Mouse2.08082217
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.06962858
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.06417023
18AR_21572438_ChIP-Seq_LNCaP_Human2.04883424
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.02797935
20E2F7_22180533_ChIP-Seq_HELA_Human10.0140934
21EZH2_22144423_ChIP-Seq_EOC_Human1.92424157
22MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91982534
23MYC_19079543_ChIP-ChIP_MESCs_Mouse1.86223558
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81305186
25RBPJ_22232070_ChIP-Seq_NCS_Mouse1.76707944
26POU5F1_16153702_ChIP-ChIP_HESCs_Human1.72156907
27YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70815689
28EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.64103453
29CIITA_25753668_ChIP-Seq_RAJI_Human1.63937599
30* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.62214214
31CTNNB1_20460455_ChIP-Seq_HCT116_Human1.61138491
32SOX2_16153702_ChIP-ChIP_HESCs_Human1.59509021
33SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.57178999
34MYC_22102868_ChIP-Seq_BL_Human1.55893824
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.49852199
36KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.48922813
37KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.48922813
38KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.48922813
39ZFP281_27345836_Chip-Seq_ESCs_Mouse1.48529415
40FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.46711672
41DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.44622281
42SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.44594937
43PKCTHETA_26484144_Chip-Seq_BREAST_Human1.41164678
44DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.38840620
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.38093774
46* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37912748
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34647084
48KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.34579349
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34509010
50ISL1_27105846_Chip-Seq_CPCs_Mouse1.34330421
51ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.30995223
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30766513
53TCF3_18692474_ChIP-Seq_MESCs_Mouse1.30181752
54EWS_26573619_Chip-Seq_HEK293_Human1.28416071
55SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.26820857
56MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.26509518
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25731144
58POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.25240797
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25120337
60SOX9_24532713_ChIP-Seq_HFSC_Mouse1.24841872
61RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.24615606
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21834460
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20834952
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20048230
65* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19665441
66SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.19132174
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18865422
68XRN2_22483619_ChIP-Seq_HELA_Human1.18573126
69NANOG_21062744_ChIP-ChIP_HESCs_Human1.17519088
70ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16170074
71P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15381998
72AR_19668381_ChIP-Seq_PC3_Human1.15031855
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14819666
74KDM2B_26808549_Chip-Seq_K562_Human1.14290862
75WT1_19549856_ChIP-ChIP_CCG9911_Human1.13673248
76NANOG_16153702_ChIP-ChIP_HESCs_Human1.13525185
77TCF7_22412390_ChIP-Seq_EML_Mouse1.13515471
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.13294148
79PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.12988892
80TCF3_18692474_ChIP-Seq_MEFs_Mouse1.12826215
81FUS_26573619_Chip-Seq_HEK293_Human1.11829158
82GBX2_23144817_ChIP-Seq_PC3_Human1.11351893
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10813923
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10602392
85CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10462095
86HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09787329
87KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09597971
88KDM2B_26808549_Chip-Seq_JURKAT_Human1.08060240
89TTF2_22483619_ChIP-Seq_HELA_Human1.06437346
90ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05997656
91WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05602304
92NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.03925757
93POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03742922
94STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03721212
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03608438
96TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.01530034
97KDM5A_27292631_Chip-Seq_BREAST_Human1.00669428
98RNF2_27304074_Chip-Seq_ESCs_Mouse0.98259879
99FOXA2_19822575_ChIP-Seq_HepG2_Human0.97800605
100OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97012863
101NANOG_18555785_ChIP-Seq_MESCs_Mouse0.96959450
102RING1B_27294783_Chip-Seq_NPCs_Mouse0.96758173
103RARB_27405468_Chip-Seq_BRAIN_Mouse0.96613134
104POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95497254
105* AHR_22903824_ChIP-Seq_MCF-7_Human0.94051045
106CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.93791643
107EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93674864
108POU5F1_16518401_ChIP-PET_MESCs_Mouse0.93393942
109MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93334423
110* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92152109
111KDM2B_26808549_Chip-Seq_DND41_Human0.92013234
112BRD4_25478319_ChIP-Seq_HGPS_Human0.91126473
113CHD1_26751641_Chip-Seq_LNCaP_Human0.88437709
114TBX3_20139965_ChIP-Seq_ESCs_Mouse0.87896304
115TBX3_20139965_ChIP-Seq_MESCs_Mouse0.86552889
116CLOCK_20551151_ChIP-Seq_293T_Human0.86365974
117* STAT3_23295773_ChIP-Seq_U87_Human0.86295438
118EZH2_18974828_ChIP-Seq_MESCs_Mouse0.86197940
119RNF2_18974828_ChIP-Seq_MESCs_Mouse0.86197940
120SOX9_26525672_Chip-Seq_HEART_Mouse0.85694224
121PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85525801
122RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.85117312
123* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.82529607
124PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82004314
125ELK1_19687146_ChIP-ChIP_HELA_Human0.81196562
126HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.78933277
127* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.78442161
128ZFX_18555785_ChIP-Seq_MESCs_Mouse0.76233506
129NFIB_24661679_ChIP-Seq_LUNG_Mouse0.73727533
130MYC_18358816_ChIP-ChIP_MESCs_Mouse0.72088648
131YAP1_20516196_ChIP-Seq_MESCs_Mouse0.71923376
132TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71526077
133POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.71526077
134CBX2_27304074_Chip-Seq_ESCs_Mouse0.71124227
135TP53_16413492_ChIP-PET_HCT116_Human0.70542659
136GATA1_26923725_Chip-Seq_HPCs_Mouse0.70068900
137SOX2_18692474_ChIP-Seq_MESCs_Mouse0.69617530

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000537_abnormal_urethra_morphology2.92493418
2MP0010030_abnormal_orbit_morphology2.78892148
3MP0008057_abnormal_DNA_replication2.57719499
4MP0003121_genomic_imprinting2.54985721
5MP0003111_abnormal_nucleus_morphology2.52136905
6MP0003123_paternal_imprinting2.39598266
7MP0010094_abnormal_chromosome_stability2.38534375
8MP0009697_abnormal_copulation2.28645382
9MP0000566_synostosis2.27531309
10MP0003122_maternal_imprinting2.17829752
11MP0003937_abnormal_limbs/digits/tail_de2.17529815
12MP0009053_abnormal_anal_canal2.13025341
13MP0002009_preneoplasia2.07521794
14MP0003077_abnormal_cell_cycle2.01327316
15MP0005409_darkened_coat_color1.95501193
16MP0003693_abnormal_embryo_hatching1.91329087
17MP0003787_abnormal_imprinting1.90444611
18MP0005257_abnormal_intraocular_pressure1.87278695
19MP0003890_abnormal_embryonic-extraembry1.86070215
20MP0001293_anophthalmia1.83145716
21MP0000049_abnormal_middle_ear1.82485199
22MP0003385_abnormal_body_wall1.74794298
23MP0005076_abnormal_cell_differentiation1.64486108
24MP0004957_abnormal_blastocyst_morpholog1.63345332
25MP0000428_abnormal_craniofacial_morphol1.62146880
26MP0003942_abnormal_urinary_system1.61526807
27MP0003755_abnormal_palate_morphology1.60813192
28MP0002084_abnormal_developmental_patter1.59827098
29MP0000569_abnormal_digit_pigmentation1.58590821
30MP0002085_abnormal_embryonic_tissue1.57532488
31MP0003935_abnormal_craniofacial_develop1.56466135
32MP0004197_abnormal_fetal_growth/weight/1.56001097
33MP0003283_abnormal_digestive_organ1.54588343
34MP0003938_abnormal_ear_development1.53972490
35MP0002249_abnormal_larynx_morphology1.52080301
36MP0008932_abnormal_embryonic_tissue1.51855170
37MP0002938_white_spotting1.49445281
38MP0003119_abnormal_digestive_system1.48832076
39MP0002932_abnormal_joint_morphology1.48347312
40MP0003115_abnormal_respiratory_system1.47792824
41MP0008058_abnormal_DNA_repair1.46692980
42MP0000350_abnormal_cell_proliferation1.46508883
43MP0008007_abnormal_cellular_replicative1.45653033
44MP0005275_abnormal_skin_tensile1.44440813
45MP0005171_absent_coat_pigmentation1.44150921
46MP0008877_abnormal_DNA_methylation1.43410672
47MP0009250_abnormal_appendicular_skeleto1.42244032
48MP0005380_embryogenesis_phenotype1.40573908
49MP0001672_abnormal_embryogenesis/_devel1.40573908
50MP0006292_abnormal_olfactory_placode1.38995991
51MP0003315_abnormal_perineum_morphology1.34253484
52MP0001730_embryonic_growth_arrest1.33878854
53MP0003861_abnormal_nervous_system1.33608360
54MP0000432_abnormal_head_morphology1.33516226
55MP0003566_abnormal_cell_adhesion1.33118738
56MP0000534_abnormal_ureter_morphology1.31343104
57MP0002233_abnormal_nose_morphology1.31287583
58MP0000733_abnormal_muscle_development1.31204723
59MP0002697_abnormal_eye_size1.30232698
60MP0001849_ear_inflammation1.29630270
61MP0002111_abnormal_tail_morphology1.29194702
62MP0002116_abnormal_craniofacial_bone1.28581659
63MP0004133_heterotaxia1.27815122
64MP0000579_abnormal_nail_morphology1.27106187
65MP0003984_embryonic_growth_retardation1.26322661
66MP0005623_abnormal_meninges_morphology1.26122212
67MP0002092_abnormal_eye_morphology1.26115516
68MP0000383_abnormal_hair_follicle1.25866427
69MP0004233_abnormal_muscle_weight1.25813813
70MP0004859_abnormal_synaptic_plasticity1.25226959
71MP0002102_abnormal_ear_morphology1.25086082
72MP0003941_abnormal_skin_development1.24238536
73MP0002088_abnormal_embryonic_growth/wei1.24049053
74MP0000462_abnormal_digestive_system1.21000361
75MP0010352_gastrointestinal_tract_polyps1.20309048
76MP0001286_abnormal_eye_development1.19172833
77MP0000778_abnormal_nervous_system1.17897957
78MP0001697_abnormal_embryo_size1.17493225
79MP0001915_intracranial_hemorrhage1.13462077
80MP0001177_atelectasis1.13324494
81MP0008789_abnormal_olfactory_epithelium1.13281206
82MP0002234_abnormal_pharynx_morphology1.12601004
83MP0002086_abnormal_extraembryonic_tissu1.12027247
84MP0010678_abnormal_skin_adnexa1.11472619
85MP0004272_abnormal_basement_membrane1.10747732
86MP0009703_decreased_birth_body1.07978746
87MP0003705_abnormal_hypodermis_morpholog1.07962626
88MP0005187_abnormal_penis_morphology1.07096045
89MP0002282_abnormal_trachea_morphology1.07015402
90MP0002114_abnormal_axial_skeleton1.06504406
91MP0009384_cardiac_valve_regurgitation1.05423491
92MP0003567_abnormal_fetal_cardiomyocyte1.05177809
93MP0002751_abnormal_autonomic_nervous1.03139727
94MP0002396_abnormal_hematopoietic_system1.02446313
95MP0010368_abnormal_lymphatic_system1.01611336
96MP0003091_abnormal_cell_migration1.01249315
97MP0004858_abnormal_nervous_system1.00042101
98MP0000762_abnormal_tongue_morphology0.98187333
99MP0002089_abnormal_postnatal_growth/wei0.98111199
100MP0002109_abnormal_limb_morphology0.98105165
101MP0000631_abnormal_neuroendocrine_gland0.97335602
102MP0005367_renal/urinary_system_phenotyp0.96407522
103MP0000516_abnormal_urinary_system0.96407522
104MP0001299_abnormal_eye_distance/0.95938553
105MP0005394_taste/olfaction_phenotype0.95901923
106MP0005499_abnormal_olfactory_system0.95901923
107MP0004134_abnormal_chest_morphology0.95556859
108MP0002080_prenatal_lethality0.95298428
109MP0002152_abnormal_brain_morphology0.95050119
110MP0005503_abnormal_tendon_morphology0.94811549
111MP0002925_abnormal_cardiovascular_devel0.93451136
112MP0002877_abnormal_melanocyte_morpholog0.92014374
113MP0002081_perinatal_lethality0.91769843
114MP0002177_abnormal_outer_ear0.90931143
115MP0004264_abnormal_extraembryonic_tissu0.88852872
116MP0002184_abnormal_innervation0.87674542
117MP0003279_aneurysm0.87605352
118MP0009672_abnormal_birth_weight0.86801354
119MP0000955_abnormal_spinal_cord0.85962301
120MP0004811_abnormal_neuron_physiology0.85840990
121MP0008438_abnormal_cutaneous_collagen0.85678192
122MP0004808_abnormal_hematopoietic_stem0.82770208
123MP0010307_abnormal_tumor_latency0.81659681
124MP0002653_abnormal_ependyma_morphology0.79808303

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)3.66904619
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.66904619
3Renal duplication (HP:0000075)2.81832964
4Abnormality of the 4th metacarpal (HP:0010012)2.79870435
5Abnormal number of incisors (HP:0011064)2.72023373
6Heterotopia (HP:0002282)2.59466978
7Shallow orbits (HP:0000586)2.58074325
8Increased nuchal translucency (HP:0010880)2.56554834
9High anterior hairline (HP:0009890)2.49858583
10Morphological abnormality of the middle ear (HP:0008609)2.47004703
11Vertebral arch anomaly (HP:0008438)2.41622881
12Ectopic kidney (HP:0000086)2.33189651
13Volvulus (HP:0002580)2.32113374
14Broad ribs (HP:0000885)2.31216458
15Bladder diverticulum (HP:0000015)2.26700105
16Hyperacusis (HP:0010780)2.25381647
17Medulloblastoma (HP:0002885)2.24734592
18Chromsome breakage (HP:0040012)2.23353343
19Chromosomal breakage induced by crosslinking agents (HP:0003221)2.22330769
20Trigonocephaly (HP:0000243)2.20824792
21Relative macrocephaly (HP:0004482)2.16194493
22Abnormality of the renal collecting system (HP:0004742)2.11791658
23Colon cancer (HP:0003003)2.10667246
24Asymmetry of the thorax (HP:0001555)2.10324682
25Skull defect (HP:0001362)2.09832139
26Abnormality of the labia minora (HP:0012880)2.08838903
27Protrusio acetabuli (HP:0003179)2.07673903
28Partial agenesis of the corpus callosum (HP:0001338)2.05597253
29Abnormality of the fingertips (HP:0001211)2.05585771
30Midline defect of the nose (HP:0004122)2.05104538
31Premature rupture of membranes (HP:0001788)2.04748973
32Renovascular hypertension (HP:0100817)2.04405961
33Arterial tortuosity (HP:0005116)2.04209397
34Lip pit (HP:0100267)2.03666534
35Supernumerary ribs (HP:0005815)2.02857905
36Abnormality of the astrocytes (HP:0100707)2.02675297
37Astrocytoma (HP:0009592)2.02675297
38Deviation of the thumb (HP:0009603)2.01627868
39Proximal placement of thumb (HP:0009623)2.01242361
40Overriding aorta (HP:0002623)2.01231607
41Abnormality of the incisor (HP:0000676)2.00735695
42Broad thumb (HP:0011304)1.98898270
43Ependymoma (HP:0002888)1.97791046
44Elfin facies (HP:0004428)1.97644194
45Long eyelashes (HP:0000527)1.97643352
46Spina bifida occulta (HP:0003298)1.96390606
47Pseudobulbar signs (HP:0002200)1.95625352
48Synostosis of carpal bones (HP:0005048)1.94010612
49Flat acetabular roof (HP:0003180)1.93478602
50Abnormality of the diencephalon (HP:0010662)1.92697981
51Abnormality of the nasal septum (HP:0000419)1.92215158
52Abnormality of cochlea (HP:0000375)1.91813137
53Flat cornea (HP:0007720)1.91442460
54Anal stenosis (HP:0002025)1.90813704
55Atresia of the external auditory canal (HP:0000413)1.90787283
56Esophageal atresia (HP:0002032)1.90669467
57Selective tooth agenesis (HP:0001592)1.90119041
58Overlapping toe (HP:0001845)1.90099636
59Glioma (HP:0009733)1.89314263
60Abnormality of the parietal bone (HP:0002696)1.87431318
61Mesomelia (HP:0003027)1.86575291
62Insomnia (HP:0100785)1.86241439
63Anophthalmia (HP:0000528)1.86006371
64Supernumerary bones of the axial skeleton (HP:0009144)1.85003175
65Bladder carcinoma (HP:0002862)1.84207491
66Bladder neoplasm (HP:0009725)1.84207491
67Wide anterior fontanel (HP:0000260)1.83638415
68Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.83504026
69Abnormality of the antihelix (HP:0009738)1.83373816
70Natal tooth (HP:0000695)1.83171072
71Uterine leiomyosarcoma (HP:0002891)1.80753426
72Leiomyosarcoma (HP:0100243)1.80753426
73Abnormality of chromosome segregation (HP:0002916)1.79633269
74Diastasis recti (HP:0001540)1.79499446
75Abnormality of the distal phalanx of the thumb (HP:0009617)1.79056339
76Hepatoblastoma (HP:0002884)1.77993942
77Nephroblastoma (Wilms tumor) (HP:0002667)1.77493190
78Broad phalanges of the hand (HP:0009768)1.77434086
79Transitional cell carcinoma of the bladder (HP:0006740)1.76252770
80Absent radius (HP:0003974)1.75188808
81Stenosis of the external auditory canal (HP:0000402)1.74565828
82Overgrowth (HP:0001548)1.74372964
83Broad palm (HP:0001169)1.74209834
84Neoplasm of the oral cavity (HP:0100649)1.73594525
85Abnormality of abdominal situs (HP:0011620)1.73348923
86Abdominal situs inversus (HP:0003363)1.73348923
87Facial hemangioma (HP:0000329)1.73026868
88Coronal craniosynostosis (HP:0004440)1.72582875
89Morphological abnormality of the inner ear (HP:0011390)1.72486842
90Patellar aplasia (HP:0006443)1.72436015
91Deviation of the hallux (HP:0010051)1.71687389
92Cutaneous finger syndactyly (HP:0010554)1.71624095
93Cubitus valgus (HP:0002967)1.71529088
94Skin tags (HP:0010609)1.71323364
95Vascular tortuosity (HP:0004948)1.71252360
96Vesicoureteral reflux (HP:0000076)1.70708533
97Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.69915666
98Prominent nose (HP:0000448)1.69865440
99Atrophic scars (HP:0001075)1.69418925
100Broad finger (HP:0001500)1.69410481
101Cerebral aneurysm (HP:0004944)1.69065438
102Embryonal renal neoplasm (HP:0011794)1.67979790
103Bowel diverticulosis (HP:0005222)1.67803664
104Turricephaly (HP:0000262)1.67747028
105Aplasia involving forearm bones (HP:0009822)1.67583642
106Absent forearm bone (HP:0003953)1.67583642
107Disproportionate tall stature (HP:0001519)1.66525204
108Thick eyebrow (HP:0000574)1.66453555
109Bilateral microphthalmos (HP:0007633)1.66244060
110Neonatal short-limb short stature (HP:0008921)1.65921292
111Carpal synostosis (HP:0009702)1.65815536
112Aplasia/Hypoplasia of the sternum (HP:0006714)1.65437018
113Aplasia/Hypoplasia of the patella (HP:0006498)1.64936975
114Smooth philtrum (HP:0000319)1.64333587
115Genetic anticipation (HP:0003743)1.64248493
116Broad toe (HP:0001837)1.64212514
117Rib fusion (HP:0000902)1.63947456
118Neoplasm of striated muscle (HP:0009728)1.63599707
119Deep philtrum (HP:0002002)1.63558435
120Arnold-Chiari malformation (HP:0002308)1.63414392
121Megalocornea (HP:0000485)1.63009652
122Dysmetric saccades (HP:0000641)1.62800136
123Hypoplasia of the maxilla (HP:0000327)1.62449432
124Vitreoretinal degeneration (HP:0000655)1.61981676
125Abnormality of the nasolacrimal system (HP:0000614)1.61933419
126Pointed chin (HP:0000307)1.61885646
127Advanced eruption of teeth (HP:0006288)1.61708595
128Cortical dysplasia (HP:0002539)1.61660200
129Neoplasm of the heart (HP:0100544)1.61001586
130Patellar dislocation (HP:0002999)1.60567818
131Short 5th finger (HP:0009237)1.60561391
132Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.60361569
133Hypoplastic labia majora (HP:0000059)1.60320135
134Preauricular skin tag (HP:0000384)1.60192687
135Ulnar bowing (HP:0003031)1.59813102
136Bifid tongue (HP:0010297)1.59791996
137Limited elbow extension (HP:0001377)1.59769116
138Hallux valgus (HP:0001822)1.59605139
139Microtia (HP:0008551)1.59560142
140Aqueductal stenosis (HP:0002410)1.59077487
141Broad phalanx (HP:0006009)1.58682173
142Obsessive-compulsive behavior (HP:0000722)1.58384240
143Abnormality of the ischium (HP:0003174)1.57489127
144Mitral valve prolapse (HP:0001634)1.56768846
145Abnormality of the carotid arteries (HP:0005344)1.56767100
146Narrow palate (HP:0000189)1.56062083
147Macroorchidism (HP:0000053)1.56042072
148Septo-optic dysplasia (HP:0100842)1.55837771
149Cutaneous syndactyly (HP:0012725)1.55193059
150Tracheomalacia (HP:0002779)1.54757547
151Down-sloping shoulders (HP:0200021)1.54691005
152Gastrointestinal carcinoma (HP:0002672)1.53730648
153Malignant gastrointestinal tract tumors (HP:0006749)1.53730648
154Ankle contracture (HP:0006466)1.53368580
155Broad long bones (HP:0005622)1.52788117
156Ankyloglossia (HP:0010296)1.52676021
157Sandal gap (HP:0001852)1.51851181
158Capillary hemangiomas (HP:0005306)1.49591577
159Deep palmar crease (HP:0006191)1.47930150
160Abnormality of the pubic bones (HP:0003172)1.45811782

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.06659114
2CDC73.91452684
3BRD42.73300564
4MKNK12.66034202
5LATS12.46712565
6MKNK22.29194075
7MAP3K102.18720723
8SRPK12.18539554
9EEF2K2.13696094
10FGFR21.92779025
11NEK21.91905873
12SMG11.89615600
13TTK1.85860695
14PASK1.78815959
15ATR1.76409419
16BUB11.71848390
17NTRK11.69808982
18DDR21.65740035
19RPS6KB21.58999616
20EPHB21.57143750
21FGFR41.56523450
22TSSK61.52770251
23CDK71.50112236
24CHEK11.47014040
25PDGFRA1.46582461
26PLK31.46254722
27BCR1.46029202
28PNCK1.42540717
29WEE11.39117340
30CHEK21.36727540
31CAMK1G1.36355707
32CSNK1A1L1.32859630
33MAP3K91.32363262
34MTOR1.29583951
35AKT31.27040380
36ICK1.24381227
37FGFR11.24295195
38FLT31.23271106
39PTK61.22204398
40PLK11.21924702
41AURKB1.18746023
42ATM1.18619667
43MET1.17497641
44NTRK21.13616581
45EPHA21.12134141
46CAMK1D1.08148335
47PAK21.05741418
48CDK61.05444198
49TYRO31.04565767
50MAP3K41.04194146
51CDK21.03693853
52CASK1.00981796
53CDK41.00967672
54RIPK11.00553298
55CDK10.99639503
56CLK10.99628145
57TTN0.98217121
58ALK0.96633840
59CDK80.94843948
60FGFR30.94091893
61PTK20.93816666
62RET0.92899906
63PDGFRB0.90761387
64ERBB20.90670923
65STK40.90066533
66YES10.89912850
67ZAK0.89179890
68STK30.89163478
69PKN20.88367712
70MELK0.87938747
71NUAK10.87844026
72SGK20.86470335
73MARK10.83825742
74SGK30.83661445
75MAPK110.80532113
76AKT20.79296668
77MARK20.79269391
78TGFBR10.79253270
79PRKD30.77149793
80SGK4940.75952827
81SGK2230.75952827
82UHMK10.75104795
83CSNK1E0.73328785
84TNIK0.71904809
85CSNK1D0.71449589
86PAK40.70363520
87BRSK20.70281878
88MAP3K80.69775965
89CSNK1G10.69342140
90STK100.69246204
91PRKDC0.69088365
92MAP3K70.68039623
93CDK90.67575233
94PRKCH0.66282816
95CSNK1G30.66244237
96TRIB30.66182706
97DMPK0.66111136
98KSR10.65767712
99PRKAA10.65201830
100ERBB30.64994001
101CAMK40.64964162
102MAPK140.64008741
103AKT10.61687843
104GSK3B0.61239354
105LATS20.60289023
106NEK60.59144087
107WNK10.56079451
108BRSK10.55879442
109DYRK30.54536454
110KSR20.54348573
111EIF2AK20.53640819
112SIK10.53449485
113CDC42BPA0.50839719
114SCYL20.50350945
115ROCK20.49693365
116CAMKK10.48816294
117STK390.48164422
118MAPK80.48006354
119CHUK0.47211003
120PRKCI0.46699922
121EPHA30.46579797
122CDK30.46476222
123AURKA0.46174367
124SIK20.46083611
125MAPK10.45154398
126BMX0.44350540
127MAP3K130.44224113
128MAPK100.44093816
129ERBB40.43962470
130RPS6KA20.43740439
131MAPK130.43348773
132PRPF4B0.43175358
133PKN10.42118155
134CDK150.40572758
135INSRR0.39959351
136NEK90.39113903
137RPS6KB10.38183161
138STK38L0.37402204
139CDK180.36409139

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052172.84251991
2Spliceosome_Homo sapiens_hsa030402.62641571
3DNA replication_Homo sapiens_hsa030302.61464906
4Cell cycle_Homo sapiens_hsa041102.52227760
5Mismatch repair_Homo sapiens_hsa034302.46127402
6mRNA surveillance pathway_Homo sapiens_hsa030152.36271168
7RNA transport_Homo sapiens_hsa030132.30095023
8Fanconi anemia pathway_Homo sapiens_hsa034602.15212194
9Homologous recombination_Homo sapiens_hsa034402.15081284
10Hedgehog signaling pathway_Homo sapiens_hsa043402.04467059
11Hippo signaling pathway_Homo sapiens_hsa043901.95393042
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.89838467
13MicroRNAs in cancer_Homo sapiens_hsa052061.86953201
14Base excision repair_Homo sapiens_hsa034101.83924334
15Non-homologous end-joining_Homo sapiens_hsa034501.73109933
16Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.70607744
17Notch signaling pathway_Homo sapiens_hsa043301.63236221
18Adherens junction_Homo sapiens_hsa045201.61009720
19Wnt signaling pathway_Homo sapiens_hsa043101.60280066
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.59956269
21Nucleotide excision repair_Homo sapiens_hsa034201.54137072
22One carbon pool by folate_Homo sapiens_hsa006701.53957134
23Small cell lung cancer_Homo sapiens_hsa052221.53144176
24Lysine degradation_Homo sapiens_hsa003101.49976451
25Axon guidance_Homo sapiens_hsa043601.47577231
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.44237779
27Colorectal cancer_Homo sapiens_hsa052101.37991915
28TGF-beta signaling pathway_Homo sapiens_hsa043501.37715695
29Prostate cancer_Homo sapiens_hsa052151.33852280
30HTLV-I infection_Homo sapiens_hsa051661.31516677
31RNA degradation_Homo sapiens_hsa030181.30548420
32Transcriptional misregulation in cancer_Homo sapiens_hsa052021.28495492
33Chronic myeloid leukemia_Homo sapiens_hsa052201.27329806
34Proteoglycans in cancer_Homo sapiens_hsa052051.27149823
35Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.21717533
36p53 signaling pathway_Homo sapiens_hsa041151.21535483
37Pathways in cancer_Homo sapiens_hsa052001.18580879
38Endometrial cancer_Homo sapiens_hsa052131.18007343
39Viral carcinogenesis_Homo sapiens_hsa052031.17638173
40Systemic lupus erythematosus_Homo sapiens_hsa053221.15667714
41Tight junction_Homo sapiens_hsa045301.14564303
42Inositol phosphate metabolism_Homo sapiens_hsa005621.11187623
43ECM-receptor interaction_Homo sapiens_hsa045121.10030307
44Focal adhesion_Homo sapiens_hsa045101.05096154
45Melanoma_Homo sapiens_hsa052181.04027289
46Oocyte meiosis_Homo sapiens_hsa041141.01192173
47Melanogenesis_Homo sapiens_hsa049160.99380029
48Prolactin signaling pathway_Homo sapiens_hsa049170.97375528
49VEGF signaling pathway_Homo sapiens_hsa043700.96497513
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94512605
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90573759
52Selenocompound metabolism_Homo sapiens_hsa004500.89982968
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89157485
54Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86804666
55Viral myocarditis_Homo sapiens_hsa054160.86340871
56Alcoholism_Homo sapiens_hsa050340.84821037
57Thyroid hormone synthesis_Homo sapiens_hsa049180.84064120
58Thyroid cancer_Homo sapiens_hsa052160.84012942
59Non-small cell lung cancer_Homo sapiens_hsa052230.83307458
60Basal transcription factors_Homo sapiens_hsa030220.83124587
61Bladder cancer_Homo sapiens_hsa052190.82843963
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82752220
63Glioma_Homo sapiens_hsa052140.81388405
64Epstein-Barr virus infection_Homo sapiens_hsa051690.80484524
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80094885
66Long-term depression_Homo sapiens_hsa047300.80013609
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79336230
68mTOR signaling pathway_Homo sapiens_hsa041500.78264857
69Pancreatic cancer_Homo sapiens_hsa052120.78119049
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77685418
71PI3K-Akt signaling pathway_Homo sapiens_hsa041510.77150242
72Long-term potentiation_Homo sapiens_hsa047200.74004646
73Insulin signaling pathway_Homo sapiens_hsa049100.72656505
74GnRH signaling pathway_Homo sapiens_hsa049120.72309495
75Rap1 signaling pathway_Homo sapiens_hsa040150.71929369
76AMPK signaling pathway_Homo sapiens_hsa041520.71886146
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.70899704
78ErbB signaling pathway_Homo sapiens_hsa040120.70691821
79HIF-1 signaling pathway_Homo sapiens_hsa040660.69709075
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68130460
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67828959
82Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67820054
83RNA polymerase_Homo sapiens_hsa030200.67621399
84Herpes simplex infection_Homo sapiens_hsa051680.66873440
85Cholinergic synapse_Homo sapiens_hsa047250.66091258
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66022729
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64187316
88Renal cell carcinoma_Homo sapiens_hsa052110.63324956
89FoxO signaling pathway_Homo sapiens_hsa040680.63229379
90Glutamatergic synapse_Homo sapiens_hsa047240.62821585
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.62752352
92B cell receptor signaling pathway_Homo sapiens_hsa046620.62587164
93Nicotine addiction_Homo sapiens_hsa050330.61478506
94Hepatitis B_Homo sapiens_hsa051610.58220231
95Steroid biosynthesis_Homo sapiens_hsa001000.57619467
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57253748
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.54610735
98Estrogen signaling pathway_Homo sapiens_hsa049150.54419704
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52933400
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52538359
101T cell receptor signaling pathway_Homo sapiens_hsa046600.50121682
102MAPK signaling pathway_Homo sapiens_hsa040100.49955398
103Pyrimidine metabolism_Homo sapiens_hsa002400.48136118
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.47844010
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47628794
106Dorso-ventral axis formation_Homo sapiens_hsa043200.47480081
107Choline metabolism in cancer_Homo sapiens_hsa052310.45988193
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45173323
109Gap junction_Homo sapiens_hsa045400.43996650
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43113387
111Protein digestion and absorption_Homo sapiens_hsa049740.42990139
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.42541244
113Acute myeloid leukemia_Homo sapiens_hsa052210.42261601
114N-Glycan biosynthesis_Homo sapiens_hsa005100.40772407
115Ras signaling pathway_Homo sapiens_hsa040140.36747057
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.36560239
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35106991
118Platelet activation_Homo sapiens_hsa046110.34220639
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32995167
120Type II diabetes mellitus_Homo sapiens_hsa049300.31877053
121Dilated cardiomyopathy_Homo sapiens_hsa054140.31453799
122Amoebiasis_Homo sapiens_hsa051460.28645137
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28217680

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