YES1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)4.47613420
2nuclear pore complex assembly (GO:0051292)4.40537041
3paraxial mesoderm development (GO:0048339)4.35836679
4notochord development (GO:0030903)3.99413834
5anterior/posterior axis specification, embryo (GO:0008595)3.78140669
6regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.71692338
7protein localization to kinetochore (GO:0034501)3.51616045
8mitotic chromosome condensation (GO:0007076)3.50831922
9DNA unwinding involved in DNA replication (GO:0006268)3.37246381
10establishment of integrated proviral latency (GO:0075713)3.35782393
11protein localization to chromosome, centromeric region (GO:0071459)3.35135079
12regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.28653246
13regulation of centriole replication (GO:0046599)3.28075054
14regulation of gene silencing by RNA (GO:0060966)3.27703759
15regulation of posttranscriptional gene silencing (GO:0060147)3.27703759
16regulation of gene silencing by miRNA (GO:0060964)3.27703759
17metaphase plate congression (GO:0051310)3.25178063
18positive regulation of SMAD protein import into nucleus (GO:0060391)3.24462479
19ribosome assembly (GO:0042255)3.19424682
20mitotic sister chromatid cohesion (GO:0007064)3.16512695
21negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.15615443
22pore complex assembly (GO:0046931)3.10760425
23sister chromatid segregation (GO:0000819)3.10727050
24intestinal epithelial cell development (GO:0060576)3.10000675
25hippo signaling (GO:0035329)3.09783908
26retina vasculature morphogenesis in camera-type eye (GO:0061299)3.05495119
27establishment of apical/basal cell polarity (GO:0035089)3.03339961
28mitotic sister chromatid segregation (GO:0000070)3.00306100
29regulation of SMAD protein import into nucleus (GO:0060390)3.00145750
30embryonic process involved in female pregnancy (GO:0060136)2.99053437
31regulation of protein polyubiquitination (GO:1902914)2.94415866
32gap junction assembly (GO:0016264)2.93476799
33regulation of mitotic spindle organization (GO:0060236)2.91070589
34homocysteine metabolic process (GO:0050667)2.90096062
35negative regulation of fatty acid biosynthetic process (GO:0045717)2.88365442
36protein complex localization (GO:0031503)2.88329791
37CENP-A containing nucleosome assembly (GO:0034080)2.87340148
38regulation of sister chromatid cohesion (GO:0007063)2.86550631
39regulation of translational fidelity (GO:0006450)2.85261085
40regulation of hippo signaling (GO:0035330)2.84202022
41regulation of helicase activity (GO:0051095)2.83660760
42negative regulation of keratinocyte proliferation (GO:0010839)2.83536201
43polarized epithelial cell differentiation (GO:0030859)2.82241097
44positive regulation of catenin import into nucleus (GO:0035413)2.78409493
45cellular protein complex localization (GO:0034629)2.77860356
46midgut development (GO:0007494)2.76372305
47pre-miRNA processing (GO:0031054)2.76313243
48chromatin remodeling at centromere (GO:0031055)2.74888026
49establishment of chromosome localization (GO:0051303)2.74451580
50regulation of RNA export from nucleus (GO:0046831)2.73595687
51bundle of His cell to Purkinje myocyte communication (GO:0086069)2.71772066
52mammary gland development (GO:0030879)2.70029337
53lymph vessel development (GO:0001945)2.70019796
54heterochromatin organization (GO:0070828)2.67023445
55replicative senescence (GO:0090399)2.66424757
56regulation of spindle organization (GO:0090224)2.66252815
57L-serine metabolic process (GO:0006563)2.65097807
58cell migration involved in sprouting angiogenesis (GO:0002042)2.63173334
59regulation of centrosome cycle (GO:0046605)2.61510808
60formation of translation preinitiation complex (GO:0001731)2.60057860
61DNA topological change (GO:0006265)2.58546053
62regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.58367814
63positive regulation of chromosome segregation (GO:0051984)2.57265167
64dorsal/ventral axis specification (GO:0009950)2.56606321
65negative regulation of chondrocyte differentiation (GO:0032331)2.56135404
66establishment of monopolar cell polarity (GO:0061162)2.53803987
67establishment or maintenance of monopolar cell polarity (GO:0061339)2.53803987
68regulation of chromosome segregation (GO:0051983)2.53165525
69regulation of heart morphogenesis (GO:2000826)2.50899068
70mitotic nuclear envelope disassembly (GO:0007077)2.50220025
71embryonic placenta development (GO:0001892)2.47517389
72non-recombinational repair (GO:0000726)2.47441276
73double-strand break repair via nonhomologous end joining (GO:0006303)2.47441276
74negative regulation of DNA repair (GO:0045738)2.46938119
75positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.45810404
76positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.45810404
77positive regulation of mitotic sister chromatid separation (GO:1901970)2.45810404
78folic acid-containing compound biosynthetic process (GO:0009396)2.45762595
79DNA replication checkpoint (GO:0000076)2.45521304
80DNA replication-independent nucleosome assembly (GO:0006336)2.45318321
81DNA replication-independent nucleosome organization (GO:0034724)2.45318321
82histone exchange (GO:0043486)2.44797524
83serine family amino acid catabolic process (GO:0009071)2.43928608
84epoxygenase P450 pathway (GO:0019373)2.43555208
85regulation of centrosome duplication (GO:0010824)2.40608120
86cell adhesion mediated by integrin (GO:0033627)2.39578228
87vascular endothelial growth factor signaling pathway (GO:0038084)2.39500478
88nuclear envelope disassembly (GO:0051081)2.38054491
89membrane disassembly (GO:0030397)2.38054491
90mesenchymal cell proliferation (GO:0010463)2.37997402
91regulation of cell fate specification (GO:0042659)2.36442919
92mitotic cytokinesis (GO:0000281)2.36114414
93tetrahydrofolate metabolic process (GO:0046653)2.34140022
94Golgi transport vesicle coating (GO:0048200)2.33331210
95COPI coating of Golgi vesicle (GO:0048205)2.33331210
96DNA duplex unwinding (GO:0032508)2.32931958
97spindle checkpoint (GO:0031577)2.32915664
98regulation of DNA endoreduplication (GO:0032875)2.31890550
99chromosome condensation (GO:0030261)2.31809461
100embryonic camera-type eye morphogenesis (GO:0048596)2.31024264
101COPII vesicle coating (GO:0048208)2.30802591
102trophectodermal cell differentiation (GO:0001829)2.30737649
103ATP-dependent chromatin remodeling (GO:0043044)2.30144159
104cell surface receptor signaling pathway involved in heart development (GO:0061311)2.29827647
105cranial suture morphogenesis (GO:0060363)2.29656851
106hemidesmosome assembly (GO:0031581)2.29498845
107DNA geometric change (GO:0032392)2.28905598
108negative regulation of cell fate specification (GO:0009996)2.28642068
109morphogenesis of an epithelial sheet (GO:0002011)2.28359235
110desmosome organization (GO:0002934)2.27376500
111embryonic camera-type eye development (GO:0031076)2.27107904
112genitalia morphogenesis (GO:0035112)2.25888216
113mitotic spindle organization (GO:0007052)2.25383212
114establishment of viral latency (GO:0019043)2.24950936
115DNA strand elongation involved in DNA replication (GO:0006271)2.24813583
116histone H2A monoubiquitination (GO:0035518)2.24473493
117endothelial cell morphogenesis (GO:0001886)2.24306325
118planar cell polarity pathway involved in neural tube closure (GO:0090179)2.23226722
119protein K6-linked ubiquitination (GO:0085020)2.22961788
120ventricular cardiac muscle cell development (GO:0055015)2.22700827
121regulation of nucleobase-containing compound transport (GO:0032239)2.22098699
122intestinal absorption (GO:0050892)2.21229648
123regulation of transforming growth factor beta2 production (GO:0032909)2.20831097
124organ formation (GO:0048645)2.20233852
125NLS-bearing protein import into nucleus (GO:0006607)2.19931798
126lymphangiogenesis (GO:0001946)2.19872647
127regulation of telomere maintenance via telomerase (GO:0032210)2.19558014
128glycine metabolic process (GO:0006544)2.18989032
129regulation of endothelial cell differentiation (GO:0045601)2.18794461
130DNA strand elongation (GO:0022616)2.18769385
131DNA ligation (GO:0006266)2.18634299
132regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.18515906
133regulation of mitotic metaphase/anaphase transition (GO:0030071)2.18515906
134positive regulation of hormone biosynthetic process (GO:0046886)2.18396735
135intestinal cholesterol absorption (GO:0030299)2.18381601
136spindle assembly involved in mitosis (GO:0090307)2.18378339
137mitotic spindle checkpoint (GO:0071174)2.18282238
138kinetochore organization (GO:0051383)2.18171881
139pituitary gland development (GO:0021983)2.17572763
140artery development (GO:0060840)2.16587049
141nucleotide-sugar biosynthetic process (GO:0009226)2.15766758
142mitotic metaphase plate congression (GO:0007080)2.15630895
143somatic diversification of immune receptors via somatic mutation (GO:0002566)2.14955806
144somatic hypermutation of immunoglobulin genes (GO:0016446)2.14955806
145tryptophan metabolic process (GO:0006568)2.14923328
146embryonic axis specification (GO:0000578)2.14786169
147regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.14636207
148apical protein localization (GO:0045176)2.14409803
149cytoplasmic mRNA processing body assembly (GO:0033962)2.14210244
150chromatin assembly (GO:0031497)2.12802601
151histone H3-K9 demethylation (GO:0033169)2.12645927
152regulation of histone H3-K9 methylation (GO:0051570)2.12263458
153regulation of keratinocyte proliferation (GO:0010837)2.12085226
154anterior/posterior axis specification (GO:0009948)2.12037644
155protein localization to chromosome (GO:0034502)2.11917993
156negative regulation of chromosome segregation (GO:0051985)2.11691729
157regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.11641801
158sulfur amino acid catabolic process (GO:0000098)2.11496461
159positive regulation of endothelial cell differentiation (GO:0045603)2.10807956
160embryonic foregut morphogenesis (GO:0048617)2.10507877
161regulation of secondary heart field cardioblast proliferation (GO:0003266)2.10208244
162regulation of cardioblast proliferation (GO:0003264)2.10208244
163regulation of mesoderm development (GO:2000380)2.09298700
164ectodermal placode formation (GO:0060788)2.07675458
165hormone catabolic process (GO:0042447)2.07447519
166regulation of bile acid biosynthetic process (GO:0070857)2.06104780
167imidazole-containing compound metabolic process (GO:0052803)2.05974659
168cell migration involved in gastrulation (GO:0042074)2.05736999
169indole-containing compound catabolic process (GO:0042436)2.05100600
170indolalkylamine catabolic process (GO:0046218)2.05100600
171tryptophan catabolic process (GO:0006569)2.05100600

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.32445552
2* SALL1_21062744_ChIP-ChIP_HESCs_Human4.34310443
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.18908278
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.02935693
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.02935693
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.02935693
7NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.89805641
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.61018195
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.53197131
10* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.47985013
11SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.44380929
12* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.35489789
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.30277017
14NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.29241356
15POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.23171419
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.21200910
17ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.17168340
18SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.16938643
19SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.15637380
20RBPJ_22232070_ChIP-Seq_NCS_Mouse2.13478646
21SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.12596486
22AR_21909140_ChIP-Seq_LNCAP_Human2.02030948
23SOX2_18555785_ChIP-Seq_MESCs_Mouse1.98003634
24EGR1_23403033_ChIP-Seq_LIVER_Mouse1.93545663
25HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.88470288
26E2F4_17652178_ChIP-ChIP_JURKAT_Human1.86958415
27SALL4_18804426_ChIP-ChIP_XEN_Mouse1.80581478
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.77754580
29RXR_22158963_ChIP-Seq_LIVER_Mouse1.76361637
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.71049038
31LXR_22158963_ChIP-Seq_LIVER_Mouse1.70992828
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.69886857
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.69618046
34* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68784905
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.68740899
36TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.67099136
37ELK1_19687146_ChIP-ChIP_HELA_Human1.66456194
38TP63_19390658_ChIP-ChIP_HaCaT_Human1.65425011
39CLOCK_20551151_ChIP-Seq_293T_Human1.63455106
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.58352269
41ZFX_18555785_ChIP-Seq_MESCs_Mouse1.58063822
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.57458773
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.57019605
44NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.54235385
45STAT3_1855785_ChIP-Seq_MESCs_Mouse1.53942322
46HIF1A_21447827_ChIP-Seq_MCF-7_Human1.52939824
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.52596188
48ZNF263_19887448_ChIP-Seq_K562_Human1.51347267
49PPARA_22158963_ChIP-Seq_LIVER_Mouse1.50464363
50FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.49044849
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48825811
52SOX17_20123909_ChIP-Seq_XEN_Mouse1.45236173
53* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43385913
54ESR1_15608294_ChIP-ChIP_MCF-7_Human1.42950463
55KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.42551508
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.41260731
57SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.36843708
58NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.36566520
59MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.35873423
60CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.34907591
61SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.31294075
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31260487
63* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.29627205
64WT1_19549856_ChIP-ChIP_CCG9911_Human1.29397816
65* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.29181776
66CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28648031
67EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.27711465
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.26273029
69TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.25557286
70YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23998741
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22695657
72NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.22404167
73POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.21738615
74FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20851404
75SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.20542209
76SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.20542209
77NANOG_16518401_ChIP-PET_MESCs_Mouse1.20503470
78BRD4_25478319_ChIP-Seq_HGPS_Human1.19421942
79CHD1_26751641_Chip-Seq_LNCaP_Human1.18376024
80* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.18121416
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.17746748
82* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.17497413
83GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16959512
84HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.16519739
85TCF4_18268006_ChIP-ChIP_LS174T_Human1.15973304
86* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.15907285
87* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.15656388
88E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15358467
89CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.13653608
90E2F1_21310950_ChIP-Seq_MCF-7_Human1.13635466
91PPAR_26484153_Chip-Seq_NCI-H1993_Human1.12971177
92FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.12784006
93* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11549425
94CDX2_20551321_ChIP-Seq_CACO-2_Human1.11376627
95KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11329455
96* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11062639
97NANOG_16153702_ChIP-ChIP_HESCs_Human1.08837178
98EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.07704699
99GATA4_25053715_ChIP-Seq_YYC3_Human1.06568887
100* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.06528311
101* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.06527092
102STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05561023
103NELFA_20434984_ChIP-Seq_ESCs_Mouse1.05540945
104FOXO3_23340844_ChIP-Seq_DLD1_Human1.05350698
105SOX2_16153702_ChIP-ChIP_HESCs_Human1.04253799
106MYC_18555785_ChIP-Seq_MESCs_Mouse1.02864871
107FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02789457
108PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.02664586
109MYC_18358816_ChIP-ChIP_MESCs_Mouse1.02420065
110NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.01959305
111SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01853200
112CJUN_26792858_Chip-Seq_BT549_Human1.01847917
113DCP1A_22483619_ChIP-Seq_HELA_Human1.01434935
114* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.00649363
115FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00644940
116WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99886256
117NANOG_21062744_ChIP-ChIP_HESCs_Human0.98459086
118EP300_21415370_ChIP-Seq_HL-1_Mouse0.97493289
119FLI1_27457419_Chip-Seq_LIVER_Mouse0.96711357
120PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96569992
121EGR1_19374776_ChIP-ChIP_THP-1_Human0.94803375
122IRF1_19129219_ChIP-ChIP_H3396_Human0.94000366
123FUS_26573619_Chip-Seq_HEK293_Human0.93991639
124AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92818996
125MYC_19079543_ChIP-ChIP_MESCs_Mouse0.92044719
126NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.91805850
127TTF2_22483619_ChIP-Seq_HELA_Human0.91645284
128EWS_26573619_Chip-Seq_HEK293_Human0.91481395
129* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91321548
130PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91163427
131GATA6_25053715_ChIP-Seq_YYC3_Human0.90161953
132PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88146651
133HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.88068873
134ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.87713620
135TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87304868
136RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87141296
137CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86837834
138FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.85126143
139POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83726519

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog2.90242948
2MP0003941_abnormal_skin_development2.75547857
3MP0004272_abnormal_basement_membrane2.45479530
4MP0002139_abnormal_hepatobiliary_system2.32694584
5MP0003806_abnormal_nucleotide_metabolis2.24674607
6MP0005085_abnormal_gallbladder_physiolo2.22812528
7MP0005360_urolithiasis2.15965219
8MP0010352_gastrointestinal_tract_polyps2.13404191
9MP0004264_abnormal_extraembryonic_tissu2.04354983
10MP0010234_abnormal_vibrissa_follicle2.01233297
11MP0008932_abnormal_embryonic_tissue1.97169515
12MP0009053_abnormal_anal_canal1.95449304
13MP0005365_abnormal_bile_salt1.95084815
14MP0005248_abnormal_Harderian_gland1.91348658
15MP0010030_abnormal_orbit_morphology1.89540166
16MP0010368_abnormal_lymphatic_system1.85652906
17MP0000516_abnormal_urinary_system1.85636847
18MP0005367_renal/urinary_system_phenotyp1.85636847
19MP0003890_abnormal_embryonic-extraembry1.84137308
20MP0000537_abnormal_urethra_morphology1.74705088
21MP0003252_abnormal_bile_duct1.72193178
22MP0001730_embryonic_growth_arrest1.64066251
23MP0000566_synostosis1.60313587
24MP0003937_abnormal_limbs/digits/tail_de1.51704932
25MP0003119_abnormal_digestive_system1.42948445
26MP0005623_abnormal_meninges_morphology1.41069454
27MP0008057_abnormal_DNA_replication1.40998410
28MP0001299_abnormal_eye_distance/1.40787024
29MP0003567_abnormal_fetal_cardiomyocyte1.40562007
30MP0000579_abnormal_nail_morphology1.40325605
31MP0009672_abnormal_birth_weight1.39062583
32MP0005187_abnormal_penis_morphology1.36896610
33MP0001346_abnormal_lacrimal_gland1.36665322
34MP0000428_abnormal_craniofacial_morphol1.34700481
35MP0004197_abnormal_fetal_growth/weight/1.33835822
36MP0002249_abnormal_larynx_morphology1.31347340
37MP0002877_abnormal_melanocyte_morpholog1.31233815
38MP0002086_abnormal_extraembryonic_tissu1.28952756
39MP0001293_anophthalmia1.28508306
40MP0002009_preneoplasia1.27595969
41MP0004957_abnormal_blastocyst_morpholog1.27409140
42MP0001915_intracranial_hemorrhage1.27312166
43MP0001879_abnormal_lymphatic_vessel1.25834751
44MP0006054_spinal_hemorrhage1.24891902
45MP0002084_abnormal_developmental_patter1.24011618
46MP0005380_embryogenesis_phenotype1.22766177
47MP0001672_abnormal_embryogenesis/_devel1.22766177
48MP0005501_abnormal_skin_physiology1.21084982
49MP0008438_abnormal_cutaneous_collagen1.18115178
50MP0005275_abnormal_skin_tensile1.17345762
51MP0005076_abnormal_cell_differentiation1.16890945
52MP0002080_prenatal_lethality1.16839810
53MP0004233_abnormal_muscle_weight1.16766477
54MP0002697_abnormal_eye_size1.16703749
55MP0003566_abnormal_cell_adhesion1.16683522
56MP0005257_abnormal_intraocular_pressure1.16392807
57MP0003385_abnormal_body_wall1.15962476
58MP0002098_abnormal_vibrissa_morphology1.14407337
59MP0008058_abnormal_DNA_repair1.13903457
60MP0003935_abnormal_craniofacial_develop1.13814145
61MP0003718_maternal_effect1.13724191
62MP0000432_abnormal_head_morphology1.12782258
63MP0003755_abnormal_palate_morphology1.11577896
64MP0002138_abnormal_hepatobiliary_system1.11343804
65MP0002088_abnormal_embryonic_growth/wei1.11129590
66MP0010094_abnormal_chromosome_stability1.11061432
67MP0009697_abnormal_copulation1.11025977
68MP0002233_abnormal_nose_morphology1.10603052
69MP0001286_abnormal_eye_development1.09981691
70MP0003984_embryonic_growth_retardation1.09823449
71MP0000762_abnormal_tongue_morphology1.08470366
72MP0004185_abnormal_adipocyte_glucose1.08090822
73MP0002085_abnormal_embryonic_tissue1.07494213
74MP0003283_abnormal_digestive_organ1.06384861
75MP0003315_abnormal_perineum_morphology1.05036126
76MP0002282_abnormal_trachea_morphology1.04934022
77MP0009250_abnormal_appendicular_skeleto1.02931432
78MP0004133_heterotaxia1.02839262
79MP0003942_abnormal_urinary_system1.00090104
80MP0002254_reproductive_system_inflammat0.99824412
81MP0003693_abnormal_embryo_hatching0.98535231
82MP0003121_genomic_imprinting0.97281412
83MP0000647_abnormal_sebaceous_gland0.96656843
84MP0010678_abnormal_skin_adnexa0.95590130
85MP0000613_abnormal_salivary_gland0.95561431
86MP0009780_abnormal_chondrocyte_physiolo0.95381344
87MP0008875_abnormal_xenobiotic_pharmacok0.94794045
88MP0003111_abnormal_nucleus_morphology0.93588844
89MP0003123_paternal_imprinting0.92445299
90MP0002938_white_spotting0.92198052
91MP0003453_abnormal_keratinocyte_physiol0.92073311
92MP0005408_hypopigmentation0.91696597
93MP0002092_abnormal_eye_morphology0.91223020
94MP0003136_yellow_coat_color0.91152216
95MP0002111_abnormal_tail_morphology0.91096992
96MP0002234_abnormal_pharynx_morphology0.90609551
97MP0003077_abnormal_cell_cycle0.90349622
98MP0005503_abnormal_tendon_morphology0.89774802
99MP0002796_impaired_skin_barrier0.89727089
100MP0000462_abnormal_digestive_system0.88887030
101MP0000350_abnormal_cell_proliferation0.88403091
102MP0001666_abnormal_nutrient_absorption0.88238932
103MP0002896_abnormal_bone_mineralization0.87185405
104MP0000427_abnormal_hair_cycle0.86551021
105MP0004019_abnormal_vitamin_homeostasis0.86462381
106MP0003861_abnormal_nervous_system0.86346954
107MP0009703_decreased_birth_body0.86303493
108MP0003868_abnormal_feces_composition0.86092598
109MP0001697_abnormal_embryo_size0.85287582
110MP0002060_abnormal_skin_morphology0.85064532
111MP0000467_abnormal_esophagus_morphology0.84723538
112MP0003950_abnormal_plasma_membrane0.83927589
113MP0004782_abnormal_surfactant_physiolog0.83629364
114MP0002925_abnormal_cardiovascular_devel0.83545272
115MP0002127_abnormal_cardiovascular_syste0.83097495
116MP0008007_abnormal_cellular_replicative0.83089792
117MP0003115_abnormal_respiratory_system0.82904401
118MP0010307_abnormal_tumor_latency0.82592931
119MP0005197_abnormal_uvea_morphology0.82064872
120MP0002932_abnormal_joint_morphology0.81665437
121MP0009384_cardiac_valve_regurgitation0.81322707
122MP0005171_absent_coat_pigmentation0.80844598
123MP0000377_abnormal_hair_follicle0.80637319
124MP0000049_abnormal_middle_ear0.79624266
125MP0000383_abnormal_hair_follicle0.79284594
126MP0000534_abnormal_ureter_morphology0.77056096
127MP0001849_ear_inflammation0.74203927
128MP0001661_extended_life_span0.72128929
129MP0003943_abnormal_hepatobiliary_system0.70305732
130MP0005409_darkened_coat_color0.70043557
131MP0002081_perinatal_lethality0.68851270
132MP0000627_abnormal_mammary_gland0.67341996

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)2.96091682
2Hypochromic microcytic anemia (HP:0004840)2.79331827
3Premature rupture of membranes (HP:0001788)2.75825947
4Biliary tract neoplasm (HP:0100574)2.74299364
5Increased nuchal translucency (HP:0010880)2.57324835
6Ankyloglossia (HP:0010296)2.51488809
7Chromosomal breakage induced by crosslinking agents (HP:0003221)2.42055962
8Abnormality of monocarboxylic acid metabolism (HP:0010996)2.41202489
9Right ventricular cardiomyopathy (HP:0011663)2.40572558
10Hypoplastic ischia (HP:0003175)2.36686388
11Colon cancer (HP:0003003)2.35742046
12Abnormal biliary tract morphology (HP:0012440)2.34219823
13Abnormality of the ischium (HP:0003174)2.33421450
14Chromsome breakage (HP:0040012)2.32837400
15Short humerus (HP:0005792)2.29607551
16Rhabdomyosarcoma (HP:0002859)2.28377177
17Asymmetry of the thorax (HP:0001555)2.26693876
18Cortical dysplasia (HP:0002539)2.25372325
19Lip pit (HP:0100267)2.23905982
20Hypoglycemic seizures (HP:0002173)2.22961710
21Arterial tortuosity (HP:0005116)2.22468007
22Abnormality of glutamine family amino acid metabolism (HP:0010902)2.19379079
23Hyperinsulinemic hypoglycemia (HP:0000825)2.17724205
24Hypoglycemic coma (HP:0001325)2.16751046
25Nephroblastoma (Wilms tumor) (HP:0002667)2.16655324
26Aplasia/hypoplasia of the humerus (HP:0006507)2.16225601
27Ependymoma (HP:0002888)2.15023008
28Esophageal varix (HP:0002040)2.14205712
29Coronal craniosynostosis (HP:0004440)2.14007608
30Pterygium (HP:0001059)2.12685360
31Shawl scrotum (HP:0000049)2.12551710
32Embryonal renal neoplasm (HP:0011794)2.11489612
33Termporal pattern (HP:0011008)2.07977479
34Insidious onset (HP:0003587)2.07977479
35Vertebral clefting (HP:0008428)2.07110082
36Hyperglycemia (HP:0003074)2.06458994
37Medulloblastoma (HP:0002885)2.04274489
38Missing ribs (HP:0000921)2.04090263
39Hypoalphalipoproteinemia (HP:0003233)2.03417627
40Hydroxyprolinuria (HP:0003080)2.01952128
41Abnormality of proline metabolism (HP:0010907)2.01952128
42Abnormality of the astrocytes (HP:0100707)2.00533081
43Astrocytoma (HP:0009592)2.00533081
44Gastrointestinal carcinoma (HP:0002672)1.98354334
45Malignant gastrointestinal tract tumors (HP:0006749)1.98354334
46Impulsivity (HP:0100710)1.96554191
47Vascular tortuosity (HP:0004948)1.96476772
48Absent radius (HP:0003974)1.95553914
49Vertebral arch anomaly (HP:0008438)1.94700177
50Epidermoid cyst (HP:0200040)1.94134619
51Hyperglycinemia (HP:0002154)1.93732125
52Neoplasm of the oral cavity (HP:0100649)1.93723432
53Skull defect (HP:0001362)1.93675619
54Abnormal lung lobation (HP:0002101)1.92859612
55Volvulus (HP:0002580)1.91022184
56Hypolipoproteinemia (HP:0010981)1.89975771
57Abnormality of oral frenula (HP:0000190)1.89039037
58Breech presentation (HP:0001623)1.88386451
59Glioma (HP:0009733)1.87903655
60Hepatoblastoma (HP:0002884)1.87450670
61Spastic diplegia (HP:0001264)1.85970192
62Abnormality of the intrinsic pathway (HP:0010989)1.85328314
63Vitreoretinal degeneration (HP:0000655)1.84595861
64Abnormality of pyrimidine metabolism (HP:0004353)1.84339955
65Rectal prolapse (HP:0002035)1.84253693
66Microglossia (HP:0000171)1.83644687
67Aplasia involving forearm bones (HP:0009822)1.83020094
68Absent forearm bone (HP:0003953)1.83020094
69Abnormal hemoglobin (HP:0011902)1.82660329
70Neoplasm of the liver (HP:0002896)1.81656505
71Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.81582562
72Hypobetalipoproteinemia (HP:0003563)1.81163101
73Portal hypertension (HP:0001409)1.80829565
74Hypoplastic labia majora (HP:0000059)1.80716835
75Esophageal atresia (HP:0002032)1.80706346
76Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.80489371
77Rib fusion (HP:0000902)1.80319495
78Neonatal short-limb short stature (HP:0008921)1.80316653
79Hyperglycinuria (HP:0003108)1.79601220
80Subacute progressive viral hepatitis (HP:0006572)1.78405787
81Synostosis of carpal bones (HP:0005048)1.78205579
82Proximal placement of thumb (HP:0009623)1.77610777
83Osteomalacia (HP:0002749)1.77492300
84Abnormality of the hepatic vasculature (HP:0006707)1.77418965
85Abnormality of the nasal septum (HP:0000419)1.77348419
86Selective tooth agenesis (HP:0001592)1.76803923
87Myelomeningocele (HP:0002475)1.75859176
88Neoplasm of the small intestine (HP:0100833)1.73233067
89Shallow orbits (HP:0000586)1.72944774
90Meckel diverticulum (HP:0002245)1.72920846
91Supernumerary spleens (HP:0009799)1.71717340
92Abnormality of dentin (HP:0010299)1.71584799
93Tetraparesis (HP:0002273)1.70758573
94Capillary hemangiomas (HP:0005306)1.70473396
95Absent eyebrow (HP:0002223)1.70143110
96Hepatocellular carcinoma (HP:0001402)1.69970767
97Absent eyelashes (HP:0000561)1.69714416
98Deep venous thrombosis (HP:0002625)1.68766259
99Abnormality of chromosome stability (HP:0003220)1.68377973
100Atrophic scars (HP:0001075)1.67885123
101Delayed puberty (HP:0000823)1.67605563
102Uterine neoplasm (HP:0010784)1.67335496
103Chorioretinal atrophy (HP:0000533)1.67255328
104Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.66317374
105Deep philtrum (HP:0002002)1.65912684
106Gastrointestinal atresia (HP:0002589)1.65252263
107Bifid tongue (HP:0010297)1.65244879
108Soft skin (HP:0000977)1.65202187
109Leiomyosarcoma (HP:0100243)1.64046426
110Uterine leiomyosarcoma (HP:0002891)1.64046426
111Thyroid carcinoma (HP:0002890)1.63762246
112Papillary thyroid carcinoma (HP:0002895)1.62925735
113Facial cleft (HP:0002006)1.62814692
114Ovarian neoplasm (HP:0100615)1.62707485
115Abnormality of the ileum (HP:0001549)1.61893192
116Abnormality of the labia minora (HP:0012880)1.61719018
117Abnormality of the labia majora (HP:0012881)1.60905659
118Breast hypoplasia (HP:0003187)1.60469898
119Deviation of the thumb (HP:0009603)1.60390667
120Ectopic kidney (HP:0000086)1.60173532
121Aplasia cutis congenita (HP:0001057)1.59783545
122Curly hair (HP:0002212)1.59145547
123Alopecia of scalp (HP:0002293)1.58428647
124Neoplasm of striated muscle (HP:0009728)1.57984314
125Short 4th metacarpal (HP:0010044)1.57604958
126Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.57604958
127Protrusio acetabuli (HP:0003179)1.56700198
128Overlapping toe (HP:0001845)1.56460552
129Aplasia/Hypoplasia of the sternum (HP:0006714)1.56372482
130Neoplasm of the rectum (HP:0100743)1.55380599
131Transitional cell carcinoma of the bladder (HP:0006740)1.55254142
132Abnormality of the distal phalanx of the thumb (HP:0009617)1.55227873
133Carpal synostosis (HP:0009702)1.53817556
134Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.53470901
135Abnormal auditory evoked potentials (HP:0006958)1.53266187
136Arnold-Chiari malformation (HP:0002308)1.53040845
137Abnormality of sulfur amino acid metabolism (HP:0004339)1.52998539
138Cutaneous syndactyly (HP:0012725)1.52335679
139Back pain (HP:0003418)1.51277333
140Aplasia involving bones of the upper limbs (HP:0009823)1.50506204
141Aplasia of the phalanges of the hand (HP:0009802)1.50506204
142Aplasia involving bones of the extremities (HP:0009825)1.50506204
143Cystic hygroma (HP:0000476)1.49990011
144Stenosis of the external auditory canal (HP:0000402)1.49497278
145Omphalocele (HP:0001539)1.49371630
146Cutaneous finger syndactyly (HP:0010554)1.48800703
147Ulnar bowing (HP:0003031)1.47315925
148High anterior hairline (HP:0009890)1.46575539
149Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.46282636
150Vertebral hypoplasia (HP:0008417)1.46282636
151Abnormality of the calcaneus (HP:0008364)1.45504497
152Breast carcinoma (HP:0003002)1.44551611
153Glossoptosis (HP:0000162)1.43990323
154Multiple enchondromatosis (HP:0005701)1.42911934
155Bladder carcinoma (HP:0002862)1.42324857
156Bladder neoplasm (HP:0009725)1.42324857
157Abnormality of the umbilical cord (HP:0010881)1.41493581
158Mitral valve prolapse (HP:0001634)1.41188673
159Ankle contracture (HP:0006466)1.40631538
160Neoplasm of the colon (HP:0100273)1.38241850
161Choanal atresia (HP:0000453)1.37961367
162Renal duplication (HP:0000075)1.37785260
163Hypopigmentation of the fundus (HP:0007894)1.36707177

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.42822119
2EPHA23.77042153
3CDK123.25780820
4FRK3.05318542
5AKT33.02899875
6STK38L2.64240844
7PBK2.52611057
8TIE12.39707345
9TNIK2.22417051
10INSRR2.01662298
11ZAK1.94388116
12TTK1.93786102
13EIF2AK11.93489867
14EIF2AK31.89973521
15DDR21.89333053
16STK31.81527197
17BUB11.76728735
18FER1.73207488
19NTRK11.73095677
20NUAK11.63812838
21SRPK11.62520262
22MET1.58528150
23SCYL21.56937003
24CDK61.56684235
25EPHB21.55744916
26ERBB41.55127871
27ERBB31.50345869
28PDGFRA1.48755236
29RPS6KB21.48334638
30MKNK21.45272156
31MAP3K101.37547362
32CDC71.36927033
33PNCK1.35847801
34BRD41.32340273
35TRIM281.31001487
36EEF2K1.30454377
37TGFBR11.29569281
38PDK21.25986587
39CDK71.22070706
40LATS21.20431721
41TGFBR21.19381250
42KDR1.17108198
43SIK11.16629123
44TAF11.15654503
45ACVR1B1.14176710
46CHEK21.13718623
47PLK31.11285100
48STK391.08979111
49NEK91.08806880
50WEE11.08472255
51MELK1.07154599
52MKNK11.05487705
53NEK11.04574906
54BCR1.04248527
55MAP3K121.03875177
56TRPM71.03407677
57MAP3K91.03043303
58STK241.01423739
59AURKB1.00539971
60PTK60.97488119
61NEK20.96504566
62MST1R0.93213510
63FLT30.92968090
64PDK30.92253018
65PDK40.92253018
66PLK10.90964768
67BRSK10.87219138
68ATM0.84909652
69PIK3CA0.83881355
70KSR10.83731636
71PAK40.83289576
72PAK20.83119018
73RIPK10.82782075
74EPHA30.80493699
75PLK40.77260622
76MTOR0.77141427
77WNK30.75819829
78MAP3K60.73919334
79BRAF0.73864833
80PASK0.73761898
81GRK10.73614899
82PLK20.72986130
83ATR0.72632707
84FGFR10.72560722
85STK100.70865440
86CHEK10.70498287
87MAP3K30.70045675
88NLK0.69067050
89FGFR20.67654595
90MAPK150.67395321
91CDK90.67144249
92PTK20.65511515
93CDK40.65414240
94ALK0.63911344
95PKN20.63205543
96MST40.62559694
97GSK3A0.59888037
98EIF2AK20.59551761
99RPS6KA40.55194477
100BMX0.53982166
101BMPR1B0.53478894
102MOS0.53394347
103ROCK20.53240926
104DMPK0.52869743
105CSNK1E0.52260230
106PRKAA20.52069403
107PRKG20.51114174
108WNK40.50651742
109CASK0.50214596
110CDK10.49793522
111CHUK0.49236024
112CAMK1D0.49087220
113CSNK1D0.48947404
114FGFR40.48619224
115FGFR30.46319676
116CDK80.44974153
117LMTK20.44270301
118AKT20.44192583
119CSNK1A1L0.43855012
120CDK20.43829974
121BCKDK0.43669907
122MAP3K80.43327128
123PRKAA10.42908405
124DYRK1B0.42701744
125TSSK60.42566588
126MAPK70.42182647
127WNK10.41328392
128PDGFRB0.40994068
129CDK30.40873874
130ERBB20.39225863
131NEK60.38988658
132BRSK20.38718366
133CAMK1G0.38641641
134MAP3K20.36947440
135AURKA0.36017918
136ARAF0.35180892
137CLK10.34883924
138KSR20.33249691

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.68734221
2One carbon pool by folate_Homo sapiens_hsa006702.55021532
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.15605917
4Arginine biosynthesis_Homo sapiens_hsa002202.08241759
5Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.02763986
6Primary bile acid biosynthesis_Homo sapiens_hsa001201.99527918
7Tryptophan metabolism_Homo sapiens_hsa003801.92659547
8Selenocompound metabolism_Homo sapiens_hsa004501.88574109
9Pentose and glucuronate interconversions_Homo sapiens_hsa000401.79640433
10* Adherens junction_Homo sapiens_hsa045201.75315090
11Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.71356395
12Maturity onset diabetes of the young_Homo sapiens_hsa049501.71041919
13Fatty acid degradation_Homo sapiens_hsa000711.63391151
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61635853
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.61322183
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.57392082
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.56597200
18Steroid biosynthesis_Homo sapiens_hsa001001.56573064
19Basal cell carcinoma_Homo sapiens_hsa052171.55725052
20TGF-beta signaling pathway_Homo sapiens_hsa043501.55118918
21Hippo signaling pathway_Homo sapiens_hsa043901.54316322
22ECM-receptor interaction_Homo sapiens_hsa045121.49766844
23Sulfur metabolism_Homo sapiens_hsa009201.48878380
24Chemical carcinogenesis_Homo sapiens_hsa052041.48807430
25Spliceosome_Homo sapiens_hsa030401.48694709
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.48194815
27Complement and coagulation cascades_Homo sapiens_hsa046101.47738862
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.46864816
29Lysine degradation_Homo sapiens_hsa003101.44693260
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.42078983
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.41550670
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.39696633
33Retinol metabolism_Homo sapiens_hsa008301.38509781
34Fanconi anemia pathway_Homo sapiens_hsa034601.37655519
35Fat digestion and absorption_Homo sapiens_hsa049751.31920599
36Mismatch repair_Homo sapiens_hsa034301.26739454
37Vitamin B6 metabolism_Homo sapiens_hsa007501.25797078
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25033790
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.23694828
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.20321837
41MicroRNAs in cancer_Homo sapiens_hsa052061.18020156
42Cell cycle_Homo sapiens_hsa041101.16935361
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.16929256
44Folate biosynthesis_Homo sapiens_hsa007901.16607593
45Propanoate metabolism_Homo sapiens_hsa006401.14504835
46PPAR signaling pathway_Homo sapiens_hsa033201.13162274
47Central carbon metabolism in cancer_Homo sapiens_hsa052301.10134490
48Small cell lung cancer_Homo sapiens_hsa052221.09892860
49RNA transport_Homo sapiens_hsa030131.09487369
50* Tight junction_Homo sapiens_hsa045301.05604221
51Histidine metabolism_Homo sapiens_hsa003401.05422187
52Starch and sucrose metabolism_Homo sapiens_hsa005001.05278398
53p53 signaling pathway_Homo sapiens_hsa041151.02311130
54Caffeine metabolism_Homo sapiens_hsa002321.02217505
55beta-Alanine metabolism_Homo sapiens_hsa004101.01374332
56Protein export_Homo sapiens_hsa030601.00593791
57Fatty acid metabolism_Homo sapiens_hsa012121.00125238
58Peroxisome_Homo sapiens_hsa041461.00036806
59Vitamin digestion and absorption_Homo sapiens_hsa049770.99804003
60Phenylalanine metabolism_Homo sapiens_hsa003600.99580955
61Protein digestion and absorption_Homo sapiens_hsa049740.97242595
62Tyrosine metabolism_Homo sapiens_hsa003500.95895147
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95026567
64Proteasome_Homo sapiens_hsa030500.94337426
65Focal adhesion_Homo sapiens_hsa045100.93663570
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93305618
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91370175
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87062820
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86774248
70Oocyte meiosis_Homo sapiens_hsa041140.86571878
71Systemic lupus erythematosus_Homo sapiens_hsa053220.86173385
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85222175
73Hedgehog signaling pathway_Homo sapiens_hsa043400.84030910
74Fatty acid biosynthesis_Homo sapiens_hsa000610.83800608
75Arginine and proline metabolism_Homo sapiens_hsa003300.82721844
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81895601
77Butanoate metabolism_Homo sapiens_hsa006500.81388063
78Prostate cancer_Homo sapiens_hsa052150.80217089
79Thyroid cancer_Homo sapiens_hsa052160.79387149
80Base excision repair_Homo sapiens_hsa034100.78812888
81Bladder cancer_Homo sapiens_hsa052190.77645063
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76328930
83RNA degradation_Homo sapiens_hsa030180.76066737
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75306903
85Colorectal cancer_Homo sapiens_hsa052100.75177893
86Nucleotide excision repair_Homo sapiens_hsa034200.74672598
87Chronic myeloid leukemia_Homo sapiens_hsa052200.74555570
88Glutathione metabolism_Homo sapiens_hsa004800.73864826
89Bile secretion_Homo sapiens_hsa049760.73438359
90Biosynthesis of amino acids_Homo sapiens_hsa012300.72787315
91Renal cell carcinoma_Homo sapiens_hsa052110.70074120
92Proteoglycans in cancer_Homo sapiens_hsa052050.69905860
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.67747991
94Wnt signaling pathway_Homo sapiens_hsa043100.66687182
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66537056
96N-Glycan biosynthesis_Homo sapiens_hsa005100.64740881
97Axon guidance_Homo sapiens_hsa043600.64025821
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63596514
99mRNA surveillance pathway_Homo sapiens_hsa030150.63390110
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62939989
101Melanoma_Homo sapiens_hsa052180.61072183
102Pancreatic cancer_Homo sapiens_hsa052120.58860316
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.58849230
104Linoleic acid metabolism_Homo sapiens_hsa005910.58692307
105Ovarian steroidogenesis_Homo sapiens_hsa049130.58049673
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57114435
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57073963
108DNA replication_Homo sapiens_hsa030300.55882124
109Fatty acid elongation_Homo sapiens_hsa000620.54974678
110Non-homologous end-joining_Homo sapiens_hsa034500.54944761
111Notch signaling pathway_Homo sapiens_hsa043300.54801284
112Pathways in cancer_Homo sapiens_hsa052000.54294350
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52995159
114Homologous recombination_Homo sapiens_hsa034400.52596213
115Pentose phosphate pathway_Homo sapiens_hsa000300.52180963
116ErbB signaling pathway_Homo sapiens_hsa040120.51938978
117Pyruvate metabolism_Homo sapiens_hsa006200.51265030
118RNA polymerase_Homo sapiens_hsa030200.50188155
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49666127
120Carbon metabolism_Homo sapiens_hsa012000.49297487
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48686978
122Melanogenesis_Homo sapiens_hsa049160.48638057
123Arachidonic acid metabolism_Homo sapiens_hsa005900.48443576
124Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47768458
125Mineral absorption_Homo sapiens_hsa049780.46927145
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46571287
127Endometrial cancer_Homo sapiens_hsa052130.46295615
128Basal transcription factors_Homo sapiens_hsa030220.45395109
129Pyrimidine metabolism_Homo sapiens_hsa002400.45280090
130Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45061434
131Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44671290
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44235916
133Thyroid hormone synthesis_Homo sapiens_hsa049180.42351351

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