

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 6.29257948 |
| 2 | ribosomal small subunit assembly (GO:0000028) | 5.48599794 |
| 3 | maturation of SSU-rRNA (GO:0030490) | 5.16637633 |
| 4 | proteasome assembly (GO:0043248) | 4.73776489 |
| 5 | protein maturation by protein folding (GO:0022417) | 4.62993504 |
| 6 | formation of translation preinitiation complex (GO:0001731) | 4.53055015 |
| 7 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.35548439 |
| 8 | nucleobase biosynthetic process (GO:0046112) | 4.35358441 |
| 9 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 4.30880657 |
| 10 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.30690910 |
| 11 | purine nucleobase biosynthetic process (GO:0009113) | 4.21100143 |
| 12 | viral transcription (GO:0019083) | 4.20852421 |
| 13 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 4.17629604 |
| 14 | ribosomal small subunit biogenesis (GO:0042274) | 4.15642841 |
| 15 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.14140390 |
| 16 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.12557028 |
| 17 | translational termination (GO:0006415) | 4.11234688 |
| 18 | pseudouridine synthesis (GO:0001522) | 4.07993351 |
| 19 | DNA strand elongation (GO:0022616) | 4.07405883 |
| 20 | cotranslational protein targeting to membrane (GO:0006613) | 4.01233756 |
| 21 | protein targeting to ER (GO:0045047) | 3.99269319 |
| 22 | DNA replication initiation (GO:0006270) | 3.94829052 |
| 23 | translational elongation (GO:0006414) | 3.92881751 |
| 24 | protein localization to endoplasmic reticulum (GO:0070972) | 3.84967592 |
| 25 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.83503359 |
| 26 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.82922115 |
| 27 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.82902655 |
| 28 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.81409665 |
| 29 | negative regulation of ligase activity (GO:0051352) | 3.81409665 |
| 30 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.81212538 |
| 31 | cullin deneddylation (GO:0010388) | 3.78366584 |
| 32 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.76478877 |
| 33 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.74090466 |
| 34 | peptidyl-arginine omega-N-methylation (GO:0035247) | 3.73536955 |
| 35 | protein deneddylation (GO:0000338) | 3.73126029 |
| 36 | telomere maintenance via recombination (GO:0000722) | 3.72014652 |
| 37 | translation (GO:0006412) | 3.71817765 |
| 38 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.71568148 |
| 39 | translational initiation (GO:0006413) | 3.69393939 |
| 40 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.68274470 |
| 41 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.67568369 |
| 42 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.67258241 |
| 43 | ribosome biogenesis (GO:0042254) | 3.63912756 |
| 44 | protein neddylation (GO:0045116) | 3.60227133 |
| 45 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.59963682 |
| 46 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.59963682 |
| 47 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.59963682 |
| 48 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.59960273 |
| 49 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.59960273 |
| 50 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 3.57937758 |
| 51 | deoxyribose phosphate biosynthetic process (GO:0046385) | 3.57937758 |
| 52 | termination of RNA polymerase III transcription (GO:0006386) | 3.57656641 |
| 53 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.57656641 |
| 54 | ribosomal large subunit biogenesis (GO:0042273) | 3.56768156 |
| 55 | DNA replication checkpoint (GO:0000076) | 3.54256251 |
| 56 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.53507217 |
| 57 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.50797044 |
| 58 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.50797044 |
| 59 | proline biosynthetic process (GO:0006561) | 3.50530660 |
| 60 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.50055684 |
| 61 | base-excision repair, AP site formation (GO:0006285) | 3.49102348 |
| 62 | deoxyribonucleotide catabolic process (GO:0009264) | 3.46493173 |
| 63 | pentose metabolic process (GO:0019321) | 3.45476427 |
| 64 | rRNA modification (GO:0000154) | 3.44014994 |
| 65 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.43361618 |
| 66 | GMP metabolic process (GO:0046037) | 3.38219285 |
| 67 | metallo-sulfur cluster assembly (GO:0031163) | 3.36228939 |
| 68 | iron-sulfur cluster assembly (GO:0016226) | 3.36228939 |
| 69 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.34633487 |
| 70 | rRNA processing (GO:0006364) | 3.33947727 |
| 71 | deoxyribose phosphate catabolic process (GO:0046386) | 3.33480860 |
| 72 | regulation of mitochondrial translation (GO:0070129) | 3.30592095 |
| 73 | ribosome assembly (GO:0042255) | 3.30125168 |
| 74 | mitochondrial calcium ion transport (GO:0006851) | 3.26208360 |
| 75 | viral life cycle (GO:0019058) | 3.26084338 |
| 76 | spliceosomal snRNP assembly (GO:0000387) | 3.25844623 |
| 77 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 3.25755812 |
| 78 | positive regulation of ligase activity (GO:0051351) | 3.25062518 |
| 79 | L-methionine salvage (GO:0071267) | 3.24842088 |
| 80 | L-methionine biosynthetic process (GO:0071265) | 3.24842088 |
| 81 | amino acid salvage (GO:0043102) | 3.24842088 |
| 82 | mitotic recombination (GO:0006312) | 3.23941069 |
| 83 | histone arginine methylation (GO:0034969) | 3.22331857 |
| 84 | cellular component biogenesis (GO:0044085) | 3.22124659 |
| 85 | cellular protein complex disassembly (GO:0043624) | 3.21908869 |
| 86 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.20643410 |
| 87 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.20346141 |
| 88 | NADH dehydrogenase complex assembly (GO:0010257) | 3.20346141 |
| 89 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.20346141 |
| 90 | rRNA metabolic process (GO:0016072) | 3.19596218 |
| 91 | protein complex biogenesis (GO:0070271) | 3.19494826 |
| 92 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.19329082 |
| 93 | telomere maintenance via telomere lengthening (GO:0010833) | 3.19283472 |
| 94 | respiratory electron transport chain (GO:0022904) | 3.16471640 |
| 95 | folic acid metabolic process (GO:0046655) | 3.15637383 |
| 96 | 2-deoxyribonucleotide metabolic process (GO:0009394) | 3.15538252 |
| 97 | GDP-mannose metabolic process (GO:0019673) | 3.14604138 |
| 98 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.14409344 |
| 99 | IMP biosynthetic process (GO:0006188) | 3.14176679 |
| 100 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.13673940 |
| 101 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.12933358 |
| 102 | electron transport chain (GO:0022900) | 3.11695129 |
| 103 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.11680539 |
| 104 | oxidative phosphorylation (GO:0006119) | 3.11200122 |
| 105 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.10228616 |
| 106 | cell cycle G1/S phase transition (GO:0044843) | 3.10228616 |
| 107 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.09123555 |
| 108 | heme biosynthetic process (GO:0006783) | 3.09024784 |
| 109 | deoxyribose phosphate metabolic process (GO:0019692) | 3.08434413 |
| 110 | nuclear envelope reassembly (GO:0031468) | 3.07028284 |
| 111 | mitotic nuclear envelope reassembly (GO:0007084) | 3.07028284 |
| 112 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.03431054 |
| 113 | protoporphyrinogen IX metabolic process (GO:0046501) | 3.02059561 |
| 114 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 3.01255264 |
| 115 | nucleobase-containing small molecule interconversion (GO:0015949) | 3.01028512 |
| 116 | negative regulation of release of cytochrome c from mitochondria (GO:0090201) | 2.99769152 |
| 117 | peptidyl-arginine N-methylation (GO:0035246) | 2.97553029 |
| 118 | peptidyl-arginine methylation (GO:0018216) | 2.97553029 |
| 119 | positive regulation of cell cycle arrest (GO:0071158) | 2.97415432 |
| 120 | regulation of ligase activity (GO:0051340) | 2.96776572 |
| 121 | 7-methylguanosine mRNA capping (GO:0006370) | 2.96081119 |
| 122 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.94815685 |
| 123 | protoporphyrinogen IX biosynthetic process (GO:0006782) | 2.93012253 |
| 124 | lipopolysaccharide biosynthetic process (GO:0009103) | 2.92574370 |
| 125 | chaperone-mediated protein transport (GO:0072321) | 2.90911913 |
| 126 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 2.90780666 |
| 127 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.89662983 |
| 128 | UTP biosynthetic process (GO:0006228) | 2.89266240 |
| 129 | folic acid-containing compound biosynthetic process (GO:0009396) | 2.88915136 |
| 130 | 7-methylguanosine RNA capping (GO:0009452) | 2.88014126 |
| 131 | RNA capping (GO:0036260) | 2.88014126 |
| 132 | L-serine metabolic process (GO:0006563) | 2.87115552 |
| 133 | protein targeting to mitochondrion (GO:0006626) | 2.86877065 |
| 134 | transcription from RNA polymerase I promoter (GO:0006360) | 2.86249954 |
| 135 | GTP biosynthetic process (GO:0006183) | 2.85833605 |
| 136 | UV protection (GO:0009650) | 2.83545160 |
| 137 | IMP metabolic process (GO:0046040) | 2.82870732 |
| 138 | heme metabolic process (GO:0042168) | 2.82141168 |
| 139 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 2.81338253 |
| 140 | protein complex disassembly (GO:0043241) | 2.80973395 |
| 141 | establishment of protein localization to mitochondrion (GO:0072655) | 2.80858709 |
| 142 | termination of RNA polymerase I transcription (GO:0006363) | 2.80034346 |
| 143 | ATP synthesis coupled proton transport (GO:0015986) | 2.78320587 |
| 144 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 2.78320587 |
| 145 | purine nucleotide salvage (GO:0032261) | 2.75971756 |
| 146 | protein localization to mitochondrion (GO:0070585) | 2.75818583 |
| 147 | UTP metabolic process (GO:0046051) | 2.75712391 |
| 148 | purine deoxyribonucleotide catabolic process (GO:0009155) | 2.75359289 |
| 149 | viral mRNA export from host cell nucleus (GO:0046784) | 2.74396631 |
| 150 | nucleotide salvage (GO:0043173) | 2.74322944 |
| 151 | deoxyribonucleotide metabolic process (GO:0009262) | 2.74249950 |
| 152 | pyrimidine nucleoside monophosphate metabolic process (GO:0009129) | 2.73829290 |
| 153 | COPI coating of Golgi vesicle (GO:0048205) | 2.73520382 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.96697414 |
| 2 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 4.22237806 |
| 3 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.14287223 |
| 4 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.71052591 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.58651728 |
| 6 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.35935175 |
| 7 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.34696842 |
| 8 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.25830948 |
| 9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.23332749 |
| 10 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.10254333 |
| 11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.00864089 |
| 12 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.75455992 |
| 13 | * MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.71085390 |
| 14 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.59544279 |
| 15 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.47613915 |
| 16 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.34239303 |
| 17 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.27480388 |
| 18 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.25504885 |
| 19 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.20054827 |
| 20 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.19599325 |
| 21 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.19057356 |
| 22 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.17382654 |
| 23 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.17239162 |
| 24 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.09053912 |
| 25 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.07515764 |
| 26 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.05464497 |
| 27 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.03684918 |
| 28 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.03670098 |
| 29 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.03023255 |
| 30 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.01139961 |
| 31 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.98898957 |
| 32 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.96061185 |
| 33 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.95280562 |
| 34 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.83629505 |
| 35 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.79108428 |
| 36 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.73150781 |
| 37 | * FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.70458170 |
| 38 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.70171951 |
| 39 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.68819311 |
| 40 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.63140390 |
| 41 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.61595995 |
| 42 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.56925066 |
| 43 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.56118986 |
| 44 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.52631153 |
| 45 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.51929704 |
| 46 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.50831906 |
| 47 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.50734088 |
| 48 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.50628927 |
| 49 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.49602475 |
| 50 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.46355480 |
| 51 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.46030106 |
| 52 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.45168708 |
| 53 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.44092808 |
| 54 | * SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.41816512 |
| 55 | NCOR1_26117541_ChIP-Seq_K562_Human | 1.40596803 |
| 56 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.37997955 |
| 57 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.37083303 |
| 58 | * TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.32879040 |
| 59 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.30221922 |
| 60 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.29883737 |
| 61 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.29408828 |
| 62 | P68_20966046_ChIP-Seq_HELA_Human | 1.26652151 |
| 63 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.25049048 |
| 64 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.24560158 |
| 65 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.24200239 |
| 66 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.23918487 |
| 67 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.23768772 |
| 68 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.22757659 |
| 69 | * MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.21904054 |
| 70 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.18850442 |
| 71 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.18203230 |
| 72 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.16525586 |
| 73 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.16362478 |
| 74 | * FOXP1_21924763_ChIP-Seq_HESCs_Human | 1.16002505 |
| 75 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.15219137 |
| 76 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.14487523 |
| 77 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.12994783 |
| 78 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.11568378 |
| 79 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.11120317 |
| 80 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.10413519 |
| 81 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.10019214 |
| 82 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.09921590 |
| 83 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 1.07933750 |
| 84 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.07702943 |
| 85 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.06165846 |
| 86 | * TFEB_21752829_ChIP-Seq_HELA_Human | 1.04293318 |
| 87 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.04093889 |
| 88 | * ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.03794331 |
| 89 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.03169208 |
| 90 | * SPI1_23547873_ChIP-Seq_NB4_Human | 1.01325974 |
| 91 | PHF8_20622854_ChIP-Seq_HELA_Human | 1.01057875 |
| 92 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.00808010 |
| 93 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.00600208 |
| 94 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.99371070 |
| 95 | MYC_22102868_ChIP-Seq_BL_Human | 0.99349298 |
| 96 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.98989282 |
| 97 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 0.98349711 |
| 98 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.98224063 |
| 99 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.98220009 |
| 100 | * CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.97720011 |
| 101 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.97651421 |
| 102 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.96863055 |
| 103 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 0.96812565 |
| 104 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.94216686 |
| 105 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.93769951 |
| 106 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.93430392 |
| 107 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.92096034 |
| 108 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.91929727 |
| 109 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.88570565 |
| 110 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.88179348 |
| 111 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.88046793 |
| 112 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 0.88008276 |
| 113 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.87440451 |
| 114 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.86136528 |
| 115 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.85530460 |
| 116 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.85332338 |
| 117 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.85092239 |
| 118 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.84956524 |
| 119 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.81266576 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.27725784 |
| 2 | MP0004957_abnormal_blastocyst_morpholog | 3.90795373 |
| 3 | MP0003806_abnormal_nucleotide_metabolis | 3.47510573 |
| 4 | MP0010094_abnormal_chromosome_stability | 3.29974101 |
| 5 | MP0003111_abnormal_nucleus_morphology | 3.27039165 |
| 6 | MP0003077_abnormal_cell_cycle | 3.18568788 |
| 7 | MP0003186_abnormal_redox_activity | 3.02749453 |
| 8 | MP0000372_irregular_coat_pigmentation | 2.84091256 |
| 9 | MP0008057_abnormal_DNA_replication | 2.79930233 |
| 10 | MP0008058_abnormal_DNA_repair | 2.71900274 |
| 11 | MP0008007_abnormal_cellular_replicative | 2.51179003 |
| 12 | MP0002396_abnormal_hematopoietic_system | 2.49261393 |
| 13 | MP0009278_abnormal_bone_marrow | 2.42138767 |
| 14 | MP0003646_muscle_fatigue | 2.18878063 |
| 15 | MP0008932_abnormal_embryonic_tissue | 2.18508630 |
| 16 | MP0006036_abnormal_mitochondrial_physio | 2.17080312 |
| 17 | MP0005451_abnormal_body_composition | 2.13368101 |
| 18 | MP0003786_premature_aging | 1.97616886 |
| 19 | MP0001853_heart_inflammation | 1.90453744 |
| 20 | MP0008260_abnormal_autophagy | 1.86192267 |
| 21 | MP0009379_abnormal_foot_pigmentation | 1.84050518 |
| 22 | MP0001542_abnormal_bone_strength | 1.80067549 |
| 23 | MP0009697_abnormal_copulation | 1.76061683 |
| 24 | MP0001764_abnormal_homeostasis | 1.74979949 |
| 25 | MP0005171_absent_coat_pigmentation | 1.73919652 |
| 26 | MP0005397_hematopoietic_system_phenotyp | 1.66815549 |
| 27 | MP0001545_abnormal_hematopoietic_system | 1.66815549 |
| 28 | MP0002132_abnormal_respiratory_system | 1.65410557 |
| 29 | MP0009333_abnormal_splenocyte_physiolog | 1.65060071 |
| 30 | MP0009840_abnormal_foam_cell | 1.63223910 |
| 31 | MP0003718_maternal_effect | 1.59403277 |
| 32 | MP0000358_abnormal_cell_content/ | 1.57337335 |
| 33 | MP0000490_abnormal_crypts_of | 1.54020628 |
| 34 | MP0006035_abnormal_mitochondrial_morpho | 1.51336738 |
| 35 | MP0008995_early_reproductive_senescence | 1.49053133 |
| 36 | MP0001730_embryonic_growth_arrest | 1.48196174 |
| 37 | MP0000015_abnormal_ear_pigmentation | 1.45083863 |
| 38 | MP0000350_abnormal_cell_proliferation | 1.43116710 |
| 39 | MP0006054_spinal_hemorrhage | 1.38346383 |
| 40 | MP0004147_increased_porphyrin_level | 1.30938282 |
| 41 | MP0000313_abnormal_cell_death | 1.30638777 |
| 42 | MP0003123_paternal_imprinting | 1.28081893 |
| 43 | MP0001661_extended_life_span | 1.26160026 |
| 44 | MP0002019_abnormal_tumor_incidence | 1.25472010 |
| 45 | MP0002653_abnormal_ependyma_morphology | 1.25329314 |
| 46 | MP0001835_abnormal_antigen_presentation | 1.21394725 |
| 47 | MP0003656_abnormal_erythrocyte_physiolo | 1.19393541 |
| 48 | MP0009764_decreased_sensitivity_to | 1.19021766 |
| 49 | MP0005075_abnormal_melanosome_morpholog | 1.17067838 |
| 50 | MP0005266_abnormal_metabolism | 1.17003980 |
| 51 | MP0002080_prenatal_lethality | 1.16965539 |
| 52 | MP0000858_altered_metastatic_potential | 1.14770760 |
| 53 | MP0004808_abnormal_hematopoietic_stem | 1.10737872 |
| 54 | MP0003436_decreased_susceptibility_to | 1.10638535 |
| 55 | MP0000689_abnormal_spleen_morphology | 1.08725276 |
| 56 | MP0002160_abnormal_reproductive_system | 1.08311971 |
| 57 | MP0005410_abnormal_fertilization | 1.08017235 |
| 58 | MP0002722_abnormal_immune_system | 1.07797549 |
| 59 | MP0000750_abnormal_muscle_regeneration | 1.06691332 |
| 60 | MP0005058_abnormal_lysosome_morphology | 1.06403179 |
| 61 | MP0003763_abnormal_thymus_physiology | 1.06003402 |
| 62 | MP0005671_abnormal_response_to | 1.05492261 |
| 63 | MP0001697_abnormal_embryo_size | 1.05370373 |
| 64 | MP0001529_abnormal_vocalization | 1.04600545 |
| 65 | MP0009785_altered_susceptibility_to | 1.03195419 |
| 66 | MP0005319_abnormal_enzyme/_coenzyme | 0.96750510 |
| 67 | MP0004084_abnormal_cardiac_muscle | 0.96621663 |
| 68 | MP0002398_abnormal_bone_marrow | 0.94294732 |
| 69 | MP0005000_abnormal_immune_tolerance | 0.94101667 |
| 70 | MP0002429_abnormal_blood_cell | 0.93831605 |
| 71 | MP0002736_abnormal_nociception_after | 0.93682232 |
| 72 | MP0003136_yellow_coat_color | 0.93466496 |
| 73 | MP0001672_abnormal_embryogenesis/_devel | 0.93381590 |
| 74 | MP0005380_embryogenesis_phenotype | 0.93381590 |
| 75 | MP0005084_abnormal_gallbladder_morpholo | 0.91606645 |
| 76 | MP0000678_abnormal_parathyroid_gland | 0.91110260 |
| 77 | MP0003724_increased_susceptibility_to | 0.90444971 |
| 78 | MP0005376_homeostasis/metabolism_phenot | 0.89761038 |
| 79 | MP0003984_embryonic_growth_retardation | 0.88717665 |
| 80 | MP0005023_abnormal_wound_healing | 0.88570132 |
| 81 | MP0001727_abnormal_embryo_implantation | 0.88041474 |
| 82 | MP0002723_abnormal_immune_serum | 0.87691961 |
| 83 | MP0010352_gastrointestinal_tract_polyps | 0.87380471 |
| 84 | MP0005636_abnormal_mineral_homeostasis | 0.87260042 |
| 85 | MP0001819_abnormal_immune_cell | 0.86140389 |
| 86 | MP0002148_abnormal_hypersensitivity_rea | 0.85997186 |
| 87 | MP0002420_abnormal_adaptive_immunity | 0.85118979 |
| 88 | MP0004133_heterotaxia | 0.84414943 |
| 89 | MP0002088_abnormal_embryonic_growth/wei | 0.84333130 |
| 90 | MP0003075_altered_response_to | 0.84238206 |
| 91 | MP0003221_abnormal_cardiomyocyte_apopto | 0.83646889 |
| 92 | MP0009763_increased_sensitivity_to | 0.83407699 |
| 93 | MP0002877_abnormal_melanocyte_morpholog | 0.83390394 |
| 94 | MP0005025_abnormal_response_to | 0.83163105 |
| 95 | MP0001905_abnormal_dopamine_level | 0.82982271 |
| 96 | MP0008469_abnormal_protein_level | 0.82168975 |
| 97 | MP0005330_cardiomyopathy | 0.81826924 |
| 98 | MP0000343_altered_response_to | 0.81417245 |
| 99 | MP0002269_muscular_atrophy | 0.80553061 |
| 100 | MP0003941_abnormal_skin_development | 0.80078891 |
| 101 | MP0001873_stomach_inflammation | 0.79236625 |
| 102 | MP0010307_abnormal_tumor_latency | 0.79114960 |
| 103 | MP0002210_abnormal_sex_determination | 0.79062949 |
| 104 | MP0002452_abnormal_antigen_presenting | 0.79039962 |
| 105 | MP0003566_abnormal_cell_adhesion | 0.78508840 |
| 106 | MP0003567_abnormal_fetal_cardiomyocyte | 0.77740896 |
| 107 | MP0001929_abnormal_gametogenesis | 0.77561240 |
| 108 | MP0005165_increased_susceptibility_to | 0.77130074 |
| 109 | MP0000598_abnormal_liver_morphology | 0.76794452 |
| 110 | MP0005332_abnormal_amino_acid | 0.75841078 |
| 111 | MP0001145_abnormal_male_reproductive | 0.75813787 |
| 112 | MP0009643_abnormal_urine_homeostasis | 0.75650682 |
| 113 | MP0000749_muscle_degeneration | 0.75015236 |
| 114 | MP0009765_abnormal_xenobiotic_induced | 0.73920263 |
| 115 | MP0003303_peritoneal_inflammation | 0.73722609 |
| 116 | MP0001881_abnormal_mammary_gland | 0.73696789 |
| 117 | MP0000716_abnormal_immune_system | 0.73577872 |
| 118 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.73266671 |
| 119 | MP0005389_reproductive_system_phenotype | 0.72280813 |
| 120 | MP0002405_respiratory_system_inflammati | 0.72207540 |
| 121 | MP0005384_cellular_phenotype | 0.71447162 |
| 122 | MP0008438_abnormal_cutaneous_collagen | 0.70765454 |
| 123 | MP0003172_abnormal_lysosome_physiology | 0.70558431 |
| 124 | MP0010030_abnormal_orbit_morphology | 0.69201880 |
| 125 | MP0005220_abnormal_exocrine_pancreas | 0.68876948 |
| 126 | MP0004782_abnormal_surfactant_physiolog | 0.68115909 |
| 127 | MP0000681_abnormal_thyroid_gland | 0.67604968 |
| 128 | MP0008775_abnormal_heart_ventricle | 0.67363563 |
| 129 | MP0000703_abnormal_thymus_morphology | 0.66922382 |
| 130 | MP0008004_abnormal_stomach_pH | 0.66570548 |
| 131 | MP0005083_abnormal_biliary_tract | 0.66484507 |
| 132 | MP0001533_abnormal_skeleton_physiology | 0.65540692 |
| 133 | MP0001845_abnormal_inflammatory_respons | 0.63785145 |
| 134 | MP0002419_abnormal_innate_immunity | 0.63691157 |
| 135 | MP0005464_abnormal_platelet_physiology | 0.63559309 |
| 136 | MP0000465_gastrointestinal_hemorrhage | 0.63528826 |
| 137 | MP0000685_abnormal_immune_system | 0.63124534 |
| 138 | MP0002086_abnormal_extraembryonic_tissu | 0.62924949 |
| 139 | MP0004233_abnormal_muscle_weight | 0.62443951 |
| 140 | MP0005501_abnormal_skin_physiology | 0.61190886 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Cholecystitis (HP:0001082) | 5.09363396 |
| 2 | Abnormal gallbladder physiology (HP:0012438) | 5.09363396 |
| 3 | Abnormal number of erythroid precursors (HP:0012131) | 4.45445960 |
| 4 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.45163846 |
| 5 | Aplastic anemia (HP:0001915) | 3.98890148 |
| 6 | Hepatic necrosis (HP:0002605) | 3.89077648 |
| 7 | Hepatocellular necrosis (HP:0001404) | 3.76290854 |
| 8 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.71946843 |
| 9 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.71946843 |
| 10 | Reticulocytopenia (HP:0001896) | 3.64463071 |
| 11 | Birth length less than 3rd percentile (HP:0003561) | 3.58840597 |
| 12 | Oral leukoplakia (HP:0002745) | 3.55564464 |
| 13 | Carpal bone hypoplasia (HP:0001498) | 3.44909519 |
| 14 | Rough bone trabeculation (HP:0100670) | 3.43101855 |
| 15 | Mitochondrial inheritance (HP:0001427) | 3.39553812 |
| 16 | Type I transferrin isoform profile (HP:0003642) | 3.35838390 |
| 17 | 3-Methylglutaconic aciduria (HP:0003535) | 3.29085160 |
| 18 | Purpura (HP:0000979) | 3.27437682 |
| 19 | Prolonged bleeding time (HP:0003010) | 3.26019183 |
| 20 | Acute necrotizing encephalopathy (HP:0006965) | 3.25339464 |
| 21 | Increased CSF lactate (HP:0002490) | 3.22143907 |
| 22 | Abnormality of the anterior horn cell (HP:0006802) | 3.20469994 |
| 23 | Degeneration of anterior horn cells (HP:0002398) | 3.20469994 |
| 24 | Increased serum lactate (HP:0002151) | 3.16834943 |
| 25 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.13162276 |
| 26 | Thrombocytosis (HP:0001894) | 3.12622793 |
| 27 | Cerebral hypomyelination (HP:0006808) | 3.11681905 |
| 28 | Hypertensive crisis (HP:0100735) | 3.08921087 |
| 29 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.06202460 |
| 30 | Hyperthyroidism (HP:0000836) | 3.02036837 |
| 31 | Reticulocytosis (HP:0001923) | 3.00073016 |
| 32 | Macrocytic anemia (HP:0001972) | 2.91277240 |
| 33 | Breast hypoplasia (HP:0003187) | 2.89268458 |
| 34 | Acute encephalopathy (HP:0006846) | 2.84609599 |
| 35 | Increased hepatocellular lipid droplets (HP:0006565) | 2.82525403 |
| 36 | Multiple enchondromatosis (HP:0005701) | 2.81849111 |
| 37 | Truncus arteriosus (HP:0001660) | 2.81518112 |
| 38 | Microretrognathia (HP:0000308) | 2.80315501 |
| 39 | Upper limb muscle weakness (HP:0003484) | 2.79247702 |
| 40 | Abnormal platelet function (HP:0011869) | 2.78088496 |
| 41 | Impaired platelet aggregation (HP:0003540) | 2.78088496 |
| 42 | Cholelithiasis (HP:0001081) | 2.74687006 |
| 43 | Hepatosplenomegaly (HP:0001433) | 2.73972011 |
| 44 | Lipid accumulation in hepatocytes (HP:0006561) | 2.73388975 |
| 45 | Reduced antithrombin III activity (HP:0001976) | 2.71713079 |
| 46 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.71712282 |
| 47 | Irregular epiphyses (HP:0010582) | 2.70014159 |
| 48 | Ragged-red muscle fibers (HP:0003200) | 2.68654260 |
| 49 | Abnormal glycosylation (HP:0012345) | 2.68451967 |
| 50 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.68451967 |
| 51 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.68451967 |
| 52 | Abnormal protein glycosylation (HP:0012346) | 2.68451967 |
| 53 | Lactic acidosis (HP:0003128) | 2.65785245 |
| 54 | Generalized aminoaciduria (HP:0002909) | 2.58586535 |
| 55 | Increased serum ferritin (HP:0003281) | 2.57230341 |
| 56 | 11 pairs of ribs (HP:0000878) | 2.57229162 |
| 57 | Abnormality of reticulocytes (HP:0004312) | 2.56105419 |
| 58 | Increased intramyocellular lipid droplets (HP:0012240) | 2.55381090 |
| 59 | Pancytopenia (HP:0001876) | 2.54190127 |
| 60 | Selective tooth agenesis (HP:0001592) | 2.52254031 |
| 61 | Exertional dyspnea (HP:0002875) | 2.51317524 |
| 62 | Pallor (HP:0000980) | 2.51178653 |
| 63 | Abnormal gallbladder morphology (HP:0012437) | 2.47836666 |
| 64 | Abnormal trabecular bone morphology (HP:0100671) | 2.46389514 |
| 65 | Exercise intolerance (HP:0003546) | 2.45395904 |
| 66 | Increased mean platelet volume (HP:0011877) | 2.40279079 |
| 67 | Respiratory failure (HP:0002878) | 2.39448046 |
| 68 | Obstructive lung disease (HP:0006536) | 2.38243771 |
| 69 | Chronic obstructive pulmonary disease (HP:0006510) | 2.38243771 |
| 70 | Trismus (HP:0000211) | 2.38146119 |
| 71 | Increased muscle lipid content (HP:0009058) | 2.38074933 |
| 72 | Secondary amenorrhea (HP:0000869) | 2.37661312 |
| 73 | CNS demyelination (HP:0007305) | 2.37459486 |
| 74 | Sparse eyelashes (HP:0000653) | 2.36195517 |
| 75 | Menorrhagia (HP:0000132) | 2.32283890 |
| 76 | Vacuolated lymphocytes (HP:0001922) | 2.31173827 |
| 77 | Abnormal platelet volume (HP:0011876) | 2.29780237 |
| 78 | Epistaxis (HP:0000421) | 2.29562426 |
| 79 | Prolonged neonatal jaundice (HP:0006579) | 2.27106716 |
| 80 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.26911314 |
| 81 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.26582626 |
| 82 | Dicarboxylic aciduria (HP:0003215) | 2.26582626 |
| 83 | Progressive muscle weakness (HP:0003323) | 2.26062231 |
| 84 | Progressive macrocephaly (HP:0004481) | 2.25010898 |
| 85 | Poor head control (HP:0002421) | 2.24116439 |
| 86 | Abnormality of glycolipid metabolism (HP:0010969) | 2.23351213 |
| 87 | Abnormality of liposaccharide metabolism (HP:0010968) | 2.23351213 |
| 88 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 2.23351213 |
| 89 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.23246394 |
| 90 | Respiratory difficulties (HP:0002880) | 2.21256858 |
| 91 | Premature graying of hair (HP:0002216) | 2.17472464 |
| 92 | Nausea (HP:0002018) | 2.17377244 |
| 93 | Cerebral palsy (HP:0100021) | 2.16936819 |
| 94 | Testicular atrophy (HP:0000029) | 2.16729746 |
| 95 | Renal Fanconi syndrome (HP:0001994) | 2.16373306 |
| 96 | Megaloblastic anemia (HP:0001889) | 2.14559085 |
| 97 | Petechiae (HP:0000967) | 2.14301792 |
| 98 | Dysautonomia (HP:0002459) | 2.12443275 |
| 99 | Cerebral edema (HP:0002181) | 2.10542848 |
| 100 | Abnormality of iron homeostasis (HP:0011031) | 2.10253757 |
| 101 | Premature ovarian failure (HP:0008209) | 2.09854255 |
| 102 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.05718721 |
| 103 | Beaking of vertebral bodies (HP:0004568) | 2.05588788 |
| 104 | Nonimmune hydrops fetalis (HP:0001790) | 2.02671135 |
| 105 | Abnormality of the gallbladder (HP:0005264) | 2.01974744 |
| 106 | Microvesicular hepatic steatosis (HP:0001414) | 2.00002988 |
| 107 | Vertebral compression fractures (HP:0002953) | 1.99900968 |
| 108 | Emotional lability (HP:0000712) | 1.99644306 |
| 109 | Hypokinesia (HP:0002375) | 1.98255561 |
| 110 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.97286946 |
| 111 | Abnormality of alanine metabolism (HP:0010916) | 1.97286946 |
| 112 | Hyperalaninemia (HP:0003348) | 1.97286946 |
| 113 | Redundant skin (HP:0001582) | 1.95825610 |
| 114 | Paralysis (HP:0003470) | 1.95607212 |
| 115 | Orthostatic hypotension (HP:0001278) | 1.95222722 |
| 116 | Abnormality of lateral ventricle (HP:0030047) | 1.93487166 |
| 117 | Seborrheic dermatitis (HP:0001051) | 1.93376179 |
| 118 | Progressive microcephaly (HP:0000253) | 1.92537699 |
| 119 | Hyperbilirubinemia (HP:0002904) | 1.90727882 |
| 120 | Slender long bone (HP:0003100) | 1.90289280 |
| 121 | Type 2 muscle fiber atrophy (HP:0003554) | 1.90060489 |
| 122 | Methylmalonic aciduria (HP:0012120) | 1.89513773 |
| 123 | Opisthotonus (HP:0002179) | 1.89249271 |
| 124 | Bone marrow hypocellularity (HP:0005528) | 1.86705740 |
| 125 | Cleft eyelid (HP:0000625) | 1.86637536 |
| 126 | Abnormal pupillary function (HP:0007686) | 1.85646030 |
| 127 | Colon cancer (HP:0003003) | 1.84529470 |
| 128 | Lethargy (HP:0001254) | 1.84414378 |
| 129 | Biconcave vertebral bodies (HP:0004586) | 1.81363729 |
| 130 | Abnormality of glycolysis (HP:0004366) | 1.80185280 |
| 131 | Increased serum pyruvate (HP:0003542) | 1.80185280 |
| 132 | Patent foramen ovale (HP:0001655) | 1.79002389 |
| 133 | Cellular immunodeficiency (HP:0005374) | 1.78785963 |
| 134 | Muscle fiber atrophy (HP:0100295) | 1.78500530 |
| 135 | Patellar aplasia (HP:0006443) | 1.77878503 |
| 136 | IgM deficiency (HP:0002850) | 1.77816073 |
| 137 | Absent thumb (HP:0009777) | 1.77789255 |
| 138 | CNS hypomyelination (HP:0003429) | 1.76956149 |
| 139 | Death in infancy (HP:0001522) | 1.76603302 |
| 140 | Glossoptosis (HP:0000162) | 1.76338005 |
| 141 | Abnormal spermatogenesis (HP:0008669) | 1.75668948 |
| 142 | Abnormality of pyrimidine metabolism (HP:0004353) | 1.72055579 |
| 143 | Severe visual impairment (HP:0001141) | 1.70442762 |
| 144 | Abnormality of the umbilical cord (HP:0010881) | 1.69346333 |
| 145 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.68738025 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.69532381 |
| 2 | STK16 | 4.32779244 |
| 3 | VRK2 | 3.99372499 |
| 4 | NME2 | 3.62850493 |
| 5 | WEE1 | 3.43028497 |
| 6 | EIF2AK1 | 3.10138443 |
| 7 | EIF2AK3 | 2.77383021 |
| 8 | PIM2 | 2.77260016 |
| 9 | BCKDK | 2.35980165 |
| 10 | TSSK6 | 2.12948850 |
| 11 | KDR | 2.09914528 |
| 12 | TESK2 | 2.03527773 |
| 13 | VRK1 | 2.03008357 |
| 14 | CDC7 | 1.77432420 |
| 15 | TESK1 | 1.68410930 |
| 16 | BRSK2 | 1.67525152 |
| 17 | PLK4 | 1.59315064 |
| 18 | SRPK1 | 1.58072660 |
| 19 | MAP4K2 | 1.56766525 |
| 20 | RIPK4 | 1.55691024 |
| 21 | PDK4 | 1.52883621 |
| 22 | PDK3 | 1.52883621 |
| 23 | BMX | 1.52191829 |
| 24 | NEK1 | 1.51760307 |
| 25 | TLK1 | 1.50409268 |
| 26 | IRAK3 | 1.47152066 |
| 27 | DYRK3 | 1.40605018 |
| 28 | ERN1 | 1.40600819 |
| 29 | EPHA2 | 1.39825649 |
| 30 | ACVR1B | 1.33467936 |
| 31 | NME1 | 1.31852908 |
| 32 | NEK2 | 1.31747272 |
| 33 | MAP3K11 | 1.30558034 |
| 34 | PDK2 | 1.24046584 |
| 35 | SMG1 | 1.22659831 |
| 36 | MYLK | 1.22478274 |
| 37 | TGFBR1 | 1.22341285 |
| 38 | MST4 | 1.22136444 |
| 39 | SCYL2 | 1.20651084 |
| 40 | CSNK1G3 | 1.18509723 |
| 41 | RPS6KA4 | 1.17815647 |
| 42 | PASK | 1.15914194 |
| 43 | PLK1 | 1.14335813 |
| 44 | TTK | 1.13376318 |
| 45 | ZAK | 1.13021671 |
| 46 | CDK7 | 1.12424940 |
| 47 | BRAF | 1.11412613 |
| 48 | IRAK4 | 1.11314666 |
| 49 | ARAF | 1.11275025 |
| 50 | NUAK1 | 1.08932376 |
| 51 | BRSK1 | 1.06051924 |
| 52 | PAK4 | 1.02471246 |
| 53 | RPS6KB2 | 1.02327272 |
| 54 | ILK | 0.98898032 |
| 55 | AURKA | 0.97602751 |
| 56 | MAP3K3 | 0.96897934 |
| 57 | TIE1 | 0.96844447 |
| 58 | MATK | 0.96124577 |
| 59 | AURKB | 0.95470077 |
| 60 | FLT3 | 0.95315696 |
| 61 | TRIB3 | 0.94403466 |
| 62 | CDK8 | 0.90623453 |
| 63 | LRRK2 | 0.89472175 |
| 64 | MAPKAPK3 | 0.88528142 |
| 65 | ABL2 | 0.87267097 |
| 66 | ATR | 0.86956956 |
| 67 | CLK1 | 0.83582426 |
| 68 | CCNB1 | 0.83005631 |
| 69 | PIM1 | 0.80756344 |
| 70 | BLK | 0.76833792 |
| 71 | RAF1 | 0.76471203 |
| 72 | MAP2K3 | 0.76149273 |
| 73 | TBK1 | 0.74860249 |
| 74 | ZAP70 | 0.74098868 |
| 75 | PKN2 | 0.73259982 |
| 76 | CSNK1A1L | 0.72169056 |
| 77 | CSNK2A1 | 0.71688058 |
| 78 | PLK3 | 0.71169178 |
| 79 | CSNK1G2 | 0.70416441 |
| 80 | PAK1 | 0.68799657 |
| 81 | MAP3K8 | 0.68774881 |
| 82 | EIF2AK2 | 0.67403057 |
| 83 | MAP2K7 | 0.67230219 |
| 84 | KIT | 0.66618577 |
| 85 | CHEK2 | 0.65950258 |
| 86 | CSNK1G1 | 0.65352290 |
| 87 | PINK1 | 0.65034188 |
| 88 | GRK6 | 0.63638544 |
| 89 | STK4 | 0.62815534 |
| 90 | TEC | 0.62329148 |
| 91 | STK10 | 0.60221724 |
| 92 | CSNK2A2 | 0.59833526 |
| 93 | TYK2 | 0.59689712 |
| 94 | MUSK | 0.59338893 |
| 95 | BMPR2 | 0.58628435 |
| 96 | CDK14 | 0.57517419 |
| 97 | LMTK2 | 0.57514901 |
| 98 | GRK5 | 0.57424364 |
| 99 | MAP4K1 | 0.54257645 |
| 100 | PKN1 | 0.52913867 |
| 101 | PRKCI | 0.51852511 |
| 102 | CDK19 | 0.51129685 |
| 103 | IKBKB | 0.49667883 |
| 104 | AKT3 | 0.49614729 |
| 105 | MAP2K2 | 0.49453564 |
| 106 | BTK | 0.49410499 |
| 107 | TAOK2 | 0.48317239 |
| 108 | CDK4 | 0.48279251 |
| 109 | LIMK1 | 0.48141750 |
| 110 | PBK | 0.47327678 |
| 111 | RPS6KA5 | 0.47236392 |
| 112 | TXK | 0.46847107 |
| 113 | MKNK1 | 0.46709965 |
| 114 | MAPKAPK5 | 0.45330355 |
| 115 | PRKG2 | 0.44521159 |
| 116 | RPS6KA6 | 0.44031531 |
| 117 | CDK11A | 0.43850071 |
| 118 | SYK | 0.42903358 |
| 119 | ADRBK2 | 0.42465303 |
| 120 | SIK3 | 0.41497621 |
| 121 | TRIM28 | 0.41480415 |
| 122 | STK24 | 0.41296266 |
| 123 | DYRK2 | 0.40775890 |
| 124 | DAPK3 | 0.39939523 |
| 125 | CHEK1 | 0.39725275 |
| 126 | MAPK11 | 0.39035840 |
| 127 | CDK15 | 0.38948879 |
| 128 | STK38L | 0.38410632 |
| 129 | MAP3K12 | 0.37935822 |
| 130 | CDK18 | 0.37820845 |
| 131 | JAK3 | 0.36310457 |
| 132 | CAMKK2 | 0.35444313 |
| 133 | MARK3 | 0.35104063 |
| 134 | DAPK1 | 0.34826888 |
| 135 | RPS6KC1 | 0.34328723 |
| 136 | LYN | 0.31585720 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.41752197 |
| 2 | DNA replication_Homo sapiens_hsa03030 | 4.28337051 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 4.11728656 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 3.26742973 |
| 5 | Mismatch repair_Homo sapiens_hsa03430 | 3.17339116 |
| 6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.73927442 |
| 7 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.71354336 |
| 8 | Base excision repair_Homo sapiens_hsa03410 | 2.62310606 |
| 9 | Protein export_Homo sapiens_hsa03060 | 2.34547676 |
| 10 | Spliceosome_Homo sapiens_hsa03040 | 2.32414567 |
| 11 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.31792070 |
| 12 | Homologous recombination_Homo sapiens_hsa03440 | 2.15709060 |
| 13 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.10766346 |
| 14 | RNA transport_Homo sapiens_hsa03013 | 2.05187127 |
| 15 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.95930464 |
| 16 | Parkinsons disease_Homo sapiens_hsa05012 | 1.89356827 |
| 17 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.84604293 |
| 18 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.82319774 |
| 19 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.71600804 |
| 20 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.71243922 |
| 21 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.56764513 |
| 22 | Huntingtons disease_Homo sapiens_hsa05016 | 1.49964562 |
| 23 | Cell cycle_Homo sapiens_hsa04110 | 1.49806607 |
| 24 | Purine metabolism_Homo sapiens_hsa00230 | 1.47795240 |
| 25 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.45362509 |
| 26 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.38541135 |
| 27 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.33919516 |
| 28 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.32314665 |
| 29 | Sulfur relay system_Homo sapiens_hsa04122 | 1.29417201 |
| 30 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.27162095 |
| 31 | Basal transcription factors_Homo sapiens_hsa03022 | 1.25764216 |
| 32 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.24062351 |
| 33 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.23482154 |
| 34 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.20177733 |
| 35 | RNA degradation_Homo sapiens_hsa03018 | 1.15747996 |
| 36 | Carbon metabolism_Homo sapiens_hsa01200 | 1.15497950 |
| 37 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.13931879 |
| 38 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.13378517 |
| 39 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.11181805 |
| 40 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.10812305 |
| 41 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.10031572 |
| 42 | Galactose metabolism_Homo sapiens_hsa00052 | 1.08656768 |
| 43 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.04502820 |
| 44 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.01179996 |
| 45 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.98752264 |
| 46 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.98135360 |
| 47 | Alzheimers disease_Homo sapiens_hsa05010 | 0.96177353 |
| 48 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.94679463 |
| 49 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.94405516 |
| 50 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.93874197 |
| 51 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.90269966 |
| 52 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.87728556 |
| 53 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.87348610 |
| 54 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.86708214 |
| 55 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.85160296 |
| 56 | Shigellosis_Homo sapiens_hsa05131 | 0.81224178 |
| 57 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.80794584 |
| 58 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.78907071 |
| 59 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.76866645 |
| 60 | Metabolic pathways_Homo sapiens_hsa01100 | 0.74342728 |
| 61 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.69652338 |
| 62 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.69476815 |
| 63 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.67578905 |
| 64 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.66269927 |
| 65 | Legionellosis_Homo sapiens_hsa05134 | 0.62966820 |
| 66 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.60833183 |
| 67 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.57859433 |
| 68 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.57678363 |
| 69 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.57389652 |
| 70 | Other glycan degradation_Homo sapiens_hsa00511 | 0.57081711 |
| 71 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.53855543 |
| 72 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.51680334 |
| 73 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.50607556 |
| 74 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.49968869 |
| 75 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.48565531 |
| 76 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.45853281 |
| 77 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.43041912 |
| 78 | Peroxisome_Homo sapiens_hsa04146 | 0.42380904 |
| 79 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.42358530 |
| 80 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.41985033 |
| 81 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.41575856 |
| 82 | Alcoholism_Homo sapiens_hsa05034 | 0.40605120 |
| 83 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.38846392 |
| 84 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.37413634 |
| 85 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.36603654 |
| 86 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.34325567 |
| 87 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.33058113 |
| 88 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.32360114 |
| 89 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.32017261 |
| 90 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.31932276 |
| 91 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.31610275 |
| 92 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.30937975 |
| 93 | Salmonella infection_Homo sapiens_hsa05132 | 0.29251826 |
| 94 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.29107838 |
| 95 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.29046663 |
| 96 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.28901119 |
| 97 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.26722453 |
| 98 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.26558035 |
| 99 | Lysosome_Homo sapiens_hsa04142 | 0.25557002 |
| 100 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.25132569 |
| 101 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.24465050 |
| 102 | Bladder cancer_Homo sapiens_hsa05219 | 0.23817057 |
| 103 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.23708871 |
| 104 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.23672032 |
| 105 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.23308904 |
| 106 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.22802224 |
| 107 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.22312107 |
| 108 | Apoptosis_Homo sapiens_hsa04210 | 0.22292253 |
| 109 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.21316431 |
| 110 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.20998099 |
| 111 | Thyroid cancer_Homo sapiens_hsa05216 | 0.20211978 |
| 112 | HTLV-I infection_Homo sapiens_hsa05166 | 0.19147036 |
| 113 | Asthma_Homo sapiens_hsa05310 | 0.18464992 |
| 114 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.18085323 |
| 115 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.17314383 |
| 116 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.17245632 |
| 117 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.16197555 |
| 118 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.15388454 |

