ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nucleotide transmembrane transport (GO:1901679)	4.44798758
2	fatty acid elongation (GO:0030497)	4.28120613
3	positive regulation by symbiont of host defense response (GO:0052509)	4.21431788
4	modulation by symbiont of host defense response (GO:0052031)	4.21431788
5	modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00	4.21431788
6	modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0	4.21431788
7	positive regulation by organism of defense response of other organism involved in symbiotic interact	4.21431788
8	modulation by symbiont of host immune response (GO:0052553)	4.21431788
9	signal peptide processing (GO:0006465)	3.91576489
10	protein complex biogenesis (GO:0070271)	3.67399089
11	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.67237237
12	NADH dehydrogenase complex assembly (GO:0010257)	3.67237237
13	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.67237237
14	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.64832474
15	pyrimidine-containing compound transmembrane transport (GO:0072531)	3.47566071
16	respiratory chain complex IV assembly (GO:0008535)	3.43145843
17	response to peptidoglycan (GO:0032494)	3.39950784
18	axon ensheathment in central nervous system (GO:0032291)	3.35324433
19	central nervous system myelination (GO:0022010)	3.35324433
20	mannosylation (GO:0097502)	3.32748847
21	GPI anchor biosynthetic process (GO:0006506)	3.29977544
22	regulation of interferon-beta biosynthetic process (GO:0045357)	3.29194001
23	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.25554679
24	macrophage activation involved in immune response (GO:0002281)	3.22810367
25	aldehyde catabolic process (GO:0046185)	3.22175306
26	negative regulation of interleukin-12 production (GO:0032695)	3.21647493
27	immunoglobulin mediated immune response (GO:0016064)	3.21472261
28	mitochondrial respiratory chain complex assembly (GO:0033108)	3.17790514
29	artery smooth muscle contraction (GO:0014824)	3.14417742
30	ATP synthesis coupled proton transport (GO:0015986)	3.12030931
31	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.12030931
32	glucuronate metabolic process (GO:0019585)	3.11844021
33	uronic acid metabolic process (GO:0006063)	3.11844021
34	amyloid precursor protein catabolic process (GO:0042987)	3.10164108
35	cholesterol biosynthetic process (GO:0006695)	3.09907096
36	respiratory burst (GO:0045730)	3.08155168
37	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.05917414
38	respiratory electron transport chain (GO:0022904)	3.02947076
39	negative regulation of interleukin-1 production (GO:0032692)	3.00938078
40	electron transport chain (GO:0022900)	2.99260890
41	nucleotide transport (GO:0006862)	2.97961414
42	negative regulation of interleukin-1 beta production (GO:0032691)	2.97800134
43	cytochrome complex assembly (GO:0017004)	2.97602941
44	neutrophil activation (GO:0042119)	2.97238973
45	GPI anchor metabolic process (GO:0006505)	2.95042656
46	cellular glucuronidation (GO:0052695)	2.92739936
47	microglial cell activation (GO:0001774)	2.91014903
48	phagosome maturation (GO:0090382)	2.90776827
49	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.88367080
50	positive regulation of cellular amine metabolic process (GO:0033240)	2.87737877
51	long-chain fatty acid biosynthetic process (GO:0042759)	2.87718477
52	preassembly of GPI anchor in ER membrane (GO:0016254)	2.87069866
53	granulocyte activation (GO:0036230)	2.86524118
54	response to interferon-beta (GO:0035456)	2.86209036
55	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	2.86171913
56	B cell mediated immunity (GO:0019724)	2.84221407
57	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.83168250
58	detection of molecule of bacterial origin (GO:0032490)	2.83130185
59	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.83064275
60	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.83064275
61	regulation of metalloenzyme activity (GO:0048552)	2.82837346
62	amyloid precursor protein metabolic process (GO:0042982)	2.80143496
63	L-methionine salvage (GO:0071267)	2.79712245
64	L-methionine biosynthetic process (GO:0071265)	2.79712245
65	amino acid salvage (GO:0043102)	2.79712245
66	sterol biosynthetic process (GO:0016126)	2.78208365
67	GDP-mannose metabolic process (GO:0019673)	2.77495212
68	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	2.75659636
69	regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	2.74353445
70	protein neddylation (GO:0045116)	2.73935070
71	response to redox state (GO:0051775)	2.73403951
72	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	2.72931055
73	superoxide anion generation (GO:0042554)	2.72700980
74	histamine secretion (GO:0001821)	2.72176388
75	positive regulation of interferon-alpha production (GO:0032727)	2.72016507
76	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.71885698
77	L-phenylalanine catabolic process (GO:0006559)	2.71885698
78	xenobiotic catabolic process (GO:0042178)	2.69826216
79	regulation of interferon-alpha production (GO:0032647)	2.68065802
80	cellular response to leptin stimulus (GO:0044320)	2.66753184
81	isoprenoid biosynthetic process (GO:0008299)	2.66291854
82	positive regulation of toll-like receptor signaling pathway (GO:0034123)	2.63617523
83	chaperone-mediated protein transport (GO:0072321)	2.63234020
84	positive regulation of monocyte chemotaxis (GO:0090026)	2.62628468
85	protein deneddylation (GO:0000338)	2.59254431
86	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.57810879
87	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.56479839
88	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.55205305
89	C-terminal protein lipidation (GO:0006501)	2.55118606
90	sequestering of actin monomers (GO:0042989)	2.52209404
91	tonic smooth muscle contraction (GO:0014820)	2.50849218
92	positive regulation of NF-kappaB import into nucleus (GO:0042346)	2.50372717
93	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.48486586
94	negative regulation of ligase activity (GO:0051352)	2.48486586
95	cullin deneddylation (GO:0010388)	2.48075712
96	negative regulation of cell killing (GO:0031342)	2.46770939
97	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	2.46770939
98	peptidyl-histidine modification (GO:0018202)	2.45521004
99	neutrophil mediated immunity (GO:0002446)	2.45044830
100	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.44874488
101	positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	2.44671673
102	glyoxylate metabolic process (GO:0046487)	2.43292068
103	positive regulation of actin cytoskeleton reorganization (GO:2000251)	2.42857009
104	pantothenate metabolic process (GO:0015939)	2.42743470
105	regulation of interleukin-8 biosynthetic process (GO:0045414)	2.42539095
106	glutathione biosynthetic process (GO:0006750)	2.42417840
107	proteasome assembly (GO:0043248)	2.42270926
108	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.42071032
109	response to host immune response (GO:0052572)	2.41783621
110	response to immune response of other organism involved in symbiotic interaction (GO:0052564)	2.41783621
111	detection of other organism (GO:0098543)	2.41751471
112	detection of external biotic stimulus (GO:0098581)	2.40774398
113	regulation of cilium movement (GO:0003352)	2.39274923
114	ATP hydrolysis coupled proton transport (GO:0015991)	2.39142657
115	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.39142657
116	carbohydrate derivative transport (GO:1901264)	2.38914473
117	nonribosomal peptide biosynthetic process (GO:0019184)	2.37066641
118	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.36654351
119	L-phenylalanine metabolic process (GO:0006558)	2.36654351
120	mitochondrial calcium ion homeostasis (GO:0051560)	2.36176288
121	sulfur amino acid catabolic process (GO:0000098)	2.35659518
122	ER overload response (GO:0006983)	2.35178571
123	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.35127896
124	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.35127896
125	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.34634695
126	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.32937928
127	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.32937928
128	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.32937928
129	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.32357534
130	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.32357534
131	myeloid leukocyte mediated immunity (GO:0002444)	2.32007144
132	regulation of cellular amine metabolic process (GO:0033238)	2.31864542
133	positive regulation of interleukin-17 production (GO:0032740)	2.31327793
134	regulation of regulatory T cell differentiation (GO:0045589)	2.31087240
135	interferon-gamma secretion (GO:0072643)	2.30859333
136	positive regulation of interferon-beta production (GO:0032728)	2.30225578
137	leukocyte migration involved in inflammatory response (GO:0002523)	2.29563560
138	myeloid cell activation involved in immune response (GO:0002275)	2.29143689
139	positive regulation of interleukin-10 production (GO:0032733)	2.28787420
140	vascular smooth muscle contraction (GO:0014829)	2.28763250
141	negative regulation of acute inflammatory response (GO:0002674)	2.27460270
142	sphingomyelin metabolic process (GO:0006684)	2.25455532
143	sphingoid metabolic process (GO:0046519)	2.25142157
144	water-soluble vitamin biosynthetic process (GO:0042364)	2.25133286
145	eye photoreceptor cell differentiation (GO:0001754)	2.25015077
146	photoreceptor cell differentiation (GO:0046530)	2.25015077
147	cofactor catabolic process (GO:0051187)	2.24970771
148	regulation of cytokine secretion involved in immune response (GO:0002739)	2.24847057
149	nucleotide-sugar biosynthetic process (GO:0009226)	2.24538990
150	hydrogen peroxide catabolic process (GO:0042744)	2.24427947
151	detection of bacterium (GO:0016045)	2.24089328
152	phagocytosis, engulfment (GO:0006911)	2.24061388
153	cellular response to interferon-beta (GO:0035458)	2.23797251
154	very long-chain fatty acid metabolic process (GO:0000038)	2.23208500
155	leukocyte aggregation (GO:0070486)	2.23114489
156	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.21976037
157	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.21279803
158	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.21076106
159	termination of RNA polymerase III transcription (GO:0006386)	2.21076106
160	regulation of cellular amino acid metabolic process (GO:0006521)	2.20748395
161	negative regulation of nitric oxide biosynthetic process (GO:0045019)	2.20238656
162	negative regulation of transcription by competitive promoter binding (GO:0010944)	2.20148564
163	neutrophil activation involved in immune response (GO:0002283)	2.19708968
164	glutathione derivative metabolic process (GO:1901685)	2.18936020
165	glutathione derivative biosynthetic process (GO:1901687)	2.18936020
166	negative regulation of chemokine production (GO:0032682)	2.18803658
167	aromatic amino acid family catabolic process (GO:0009074)	2.18685514
168	purine ribonucleotide transport (GO:0015868)	2.18344089
169	opsonization (GO:0008228)	2.17864518
170	C-terminal protein amino acid modification (GO:0018410)	2.15747090
171	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	2.15292598
172	intracellular pH reduction (GO:0051452)	2.15044789
173	glutathione metabolic process (GO:0006749)	2.14072218
174	antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	2.13945699
175	ribosomal small subunit assembly (GO:0000028)	2.13433331
176	regulation of antigen processing and presentation (GO:0002577)	2.13277600
177	aerobic respiration (GO:0009060)	2.13190540
178	negative regulation of execution phase of apoptosis (GO:1900118)	2.12912915
179	pH reduction (GO:0045851)	2.12690159
180	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	2.11498636
181	proton transport (GO:0015992)	2.11470441
182	fucose metabolic process (GO:0006004)	2.11227619
183	sulfation (GO:0051923)	2.10483501
184	nucleotide-sugar metabolic process (GO:0009225)	2.09417874

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.44933073
2	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	4.26923247
3	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.76993345
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.64078691
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.63623670
6	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.62257027
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.50627858
8	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.46036133
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.43873384
10	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.37957119
11	SPI1_23547873_ChIP-Seq_NB4_Human	2.23450760
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.22964832
13	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.21658683
14	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.20268371
15	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.08582617
16	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.05917583
17	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.04501965
18	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.01097591
19	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.98069306
20	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.91690470
21	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.87093623
22	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.86866876
23	VDR_23849224_ChIP-Seq_CD4+_Human	1.83454203
24	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.80060751
25	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.80044791
26	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.78166289
27	* FOXP3_21729870_ChIP-Seq_TREG_Human	1.70313144
28	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.64997278
29	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.64018486
30	ELK1_19687146_ChIP-ChIP_HELA_Human	1.63718445
31	TAF15_26573619_Chip-Seq_HEK293_Human	1.61896577
32	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.61621062
33	HTT_18923047_ChIP-ChIP_STHdh_Human	1.61074970
34	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.60620624
35	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.56002265
36	GBX2_23144817_ChIP-Seq_PC3_Human	1.54552664
37	VDR_22108803_ChIP-Seq_LS180_Human	1.54315789
38	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.52491657
39	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.52260000
40	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.50280381
41	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.48681170
42	TFEB_21752829_ChIP-Seq_HELA_Human	1.45823207
43	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.45508994
44	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.42848462
45	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.40668054
46	CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.40555734
47	* E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.38650279
48	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.34511114
49	GABP_19822575_ChIP-Seq_HepG2_Human	1.34263279
50	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.32127910
51	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.30307306
52	* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.29819142
53	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.28455549
54	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.27757056
55	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.25357349
56	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.22543470
57	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.22257970
58	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.20479517
59	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.19420551
60	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.19172393
61	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.19172393
62	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.19172393
63	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.19083446
64	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.16377789
65	CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.15140462
66	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.14918536
67	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.13507429
68	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.11950779
69	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.11878842
70	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.11139357
71	* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.10803474
72	* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.10796706
73	DCP1A_22483619_ChIP-Seq_HELA_Human	1.10728860
74	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.10484133
75	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.10282061
76	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.09723196
77	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.09248988
78	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.08092999
79	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.08073750
80	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.07809189
81	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.07498374
82	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.07071547
83	SOX2_20726797_ChIP-Seq_SW620_Human	1.07014712
84	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.06994274
85	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.06354429
86	AR_20517297_ChIP-Seq_VCAP_Human	1.05906534
87	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.05185886
88	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.04860500
89	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.04716272
90	ER_23166858_ChIP-Seq_MCF-7_Human	1.04216917
91	* EOMES_21245162_ChIP-Seq_HESCs_Human	1.03500313
92	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.03482514
93	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.03358364
94	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.03206220
95	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.03173476
96	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.02618486
97	* PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.02351279
98	GATA3_26560356_Chip-Seq_TH2_Human	1.01233682
99	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.01018605
100	IGF1R_20145208_ChIP-Seq_DFB_Human	1.00868350
101	RUNX1_27457419_Chip-Seq_LIVER_Mouse	1.00549179
102	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.99698697
103	ELF5_23300383_ChIP-Seq_T47D_Human	0.98882942
104	SMAD1_18555785_Chip-Seq_ESCs_Mouse	0.98469411
105	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.97832064
106	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.97054281
107	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.97054281
108	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.95986672
109	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.95621776
110	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.95424396
111	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.95245243
112	PPARA_22158963_ChIP-Seq_LIVER_Mouse	0.94918688
113	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.94906707
114	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.94073719
115	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.92542588
116	SMAD_19615063_ChIP-ChIP_OVARY_Human	0.92282371
117	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.92192947
118	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	0.91893362
119	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.91779458
120	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.90721033
121	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.90670926
122	STAT1_20625510_ChIP-Seq_HELA_Human	0.90632826
123	LXR_22158963_ChIP-Seq_LIVER_Mouse	0.90554827
124	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.90343611
125	BRD4_27068464_Chip-Seq_AML-cells_Mouse	0.90187334
126	ERG_20517297_ChIP-Seq_VCAP_Human	0.90067284
127	NANOG_19829295_ChIP-Seq_ESCs_Human	0.90039349
128	SOX2_19829295_ChIP-Seq_ESCs_Human	0.90039349
129	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.89953979
130	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.89674489
131	MYB_26560356_Chip-Seq_TH2_Human	0.89114499
132	P53_22387025_ChIP-Seq_ESCs_Mouse	0.89017344
133	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.88987619
134	CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.88893913
135	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.88865039
136	P300_18555785_Chip-Seq_ESCs_Mouse	0.88862750
137	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.88712205
138	P300_19829295_ChIP-Seq_ESCs_Human	0.88605959
139	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.87911389
140	PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.87790529
141	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.87622538
142	* IRF8_27001747_Chip-Seq_BMDM_Mouse	0.87408118
143	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.87094140
144	AR_21572438_ChIP-Seq_LNCaP_Human	0.86404337
145	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.86050119
146	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.85430998
147	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.84864576
148	* HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.84519018
149	SPI1_23127762_ChIP-Seq_K562_Human	0.84078862
150	KLF4_18555785_Chip-Seq_ESCs_Mouse	0.84049886
151	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.84009810
152	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.83650085
153	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.82172931

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001986_abnormal_taste_sensitivity	3.34433294
2	MP0008875_abnormal_xenobiotic_pharmacok	2.54468680
3	MP0002876_abnormal_thyroid_physiology	2.54200550
4	MP0009379_abnormal_foot_pigmentation	2.42008387
5	MP0001835_abnormal_antigen_presentation	2.38820902
6	MP0002139_abnormal_hepatobiliary_system	2.34933899
7	MP0005360_urolithiasis	2.28616581
8	MP0003303_peritoneal_inflammation	2.26117855
9	MP0009785_altered_susceptibility_to	2.22494314
10	MP0003195_calcinosis	2.18188648
11	MP0003724_increased_susceptibility_to	2.12273596
12	MP0001905_abnormal_dopamine_level	2.07910106
13	MP0005451_abnormal_body_composition	2.02892818
14	MP0002822_catalepsy	1.98569835
15	MP0002148_abnormal_hypersensitivity_rea	1.94196791
16	MP0006082_CNS_inflammation	1.92349889
17	MP0003806_abnormal_nucleotide_metabolis	1.89456810
18	MP0005085_abnormal_gallbladder_physiolo	1.88298425
19	MP0005671_abnormal_response_to	1.83046710
20	MP0009278_abnormal_bone_marrow	1.82627274
21	MP0008260_abnormal_autophagy	1.81103938
22	MP0001666_abnormal_nutrient_absorption	1.77826483
23	MP0000685_abnormal_immune_system	1.76135403
24	MP0005310_abnormal_salivary_gland	1.75714520
25	MP0001529_abnormal_vocalization	1.70784673
26	MP0004134_abnormal_chest_morphology	1.70178175
27	MP0001542_abnormal_bone_strength	1.69635287
28	MP0000343_altered_response_to	1.65215533
29	MP0003186_abnormal_redox_activity	1.65053930
30	MP0005365_abnormal_bile_salt	1.62425898
31	MP0010386_abnormal_urinary_bladder	1.61327898
32	MP0002132_abnormal_respiratory_system	1.60036316
33	MP0005058_abnormal_lysosome_morphology	1.59474322
34	MP0000920_abnormal_myelination	1.54342949
35	MP0001873_stomach_inflammation	1.54053569
36	MP0005025_abnormal_response_to	1.53863697
37	MP0004147_increased_porphyrin_level	1.50377272
38	MP0005000_abnormal_immune_tolerance	1.48178123
39	MP0002933_joint_inflammation	1.46488459
40	MP0005387_immune_system_phenotype	1.45611972
41	MP0001790_abnormal_immune_system	1.45611972
42	MP0005645_abnormal_hypothalamus_physiol	1.44722438
43	MP0001764_abnormal_homeostasis	1.44576433
44	MP0004381_abnormal_hair_follicle	1.43711579
45	MP0003868_abnormal_feces_composition	1.43124848
46	MP0002419_abnormal_innate_immunity	1.40614830
47	MP0003172_abnormal_lysosome_physiology	1.33337234
48	MP0004019_abnormal_vitamin_homeostasis	1.32107723
49	MP0005379_endocrine/exocrine_gland_phen	1.31875801
50	MP0004043_abnormal_pH_regulation	1.30885925
51	MP0002138_abnormal_hepatobiliary_system	1.30707909
52	MP0003866_abnormal_defecation	1.30025198
53	MP0003436_decreased_susceptibility_to	1.28846160
54	MP0002090_abnormal_vision	1.27255223
55	MP0003191_abnormal_cellular_cholesterol	1.26516996
56	MP0005332_abnormal_amino_acid	1.25979906
57	MP0005166_decreased_susceptibility_to	1.25437617
58	MP0005636_abnormal_mineral_homeostasis	1.23330847
59	MP0001663_abnormal_digestive_system	1.22892803
60	MP0002277_abnormal_respiratory_mucosa	1.22719137
61	MP0006035_abnormal_mitochondrial_morpho	1.21588180
62	MP0002723_abnormal_immune_serum	1.20647897
63	MP0000465_gastrointestinal_hemorrhage	1.19653736
64	MP0005381_digestive/alimentary_phenotyp	1.19001998
65	MP0003300_gastrointestinal_ulcer	1.18581571
66	MP0001800_abnormal_humoral_immune	1.18299525
67	MP0009840_abnormal_foam_cell	1.15747403
68	MP0003075_altered_response_to	1.15710647
69	MP0003183_abnormal_peptide_metabolism	1.15354482
70	MP0004142_abnormal_muscle_tone	1.13785954
71	MP0004883_abnormal_blood_vessel	1.13249840
72	MP0009765_abnormal_xenobiotic_induced	1.12899134
73	MP0005464_abnormal_platelet_physiology	1.12405181
74	MP0002452_abnormal_antigen_presenting	1.12124301
75	MP0009697_abnormal_copulation	1.11305035
76	MP0008469_abnormal_protein_level	1.10680564
77	MP0005084_abnormal_gallbladder_morpholo	1.10474400
78	MP0001188_hyperpigmentation	1.08989622
79	MP0002163_abnormal_gland_morphology	1.08508993
80	MP0003136_yellow_coat_color	1.08384464
81	MP0001664_abnormal_digestion	1.08056085
82	MP0003828_pulmonary_edema	1.07672087
83	MP0000604_amyloidosis	1.06766421
84	MP0008789_abnormal_olfactory_epithelium	1.06747648
85	MP0000858_altered_metastatic_potential	1.06453126
86	MP0002254_reproductive_system_inflammat	1.06247607
87	MP0004742_abnormal_vestibular_system	1.05748014
88	MP0004782_abnormal_surfactant_physiolog	1.05304997
89	MP0009643_abnormal_urine_homeostasis	1.04181536
90	MP0001853_heart_inflammation	1.03712472
91	MP0003690_abnormal_glial_cell	1.03078358
92	MP0002420_abnormal_adaptive_immunity	1.02614694
93	MP0001533_abnormal_skeleton_physiology	1.02404217
94	MP0009384_cardiac_valve_regurgitation	1.01886187
95	MP0001819_abnormal_immune_cell	1.01771946
96	MP0001984_abnormal_olfaction	1.01001516
97	MP0005394_taste/olfaction_phenotype	1.00815394
98	MP0005499_abnormal_olfactory_system	1.00815394
99	MP0010155_abnormal_intestine_physiology	0.99836333
100	MP0001845_abnormal_inflammatory_respons	0.99306093
101	MP0003011_delayed_dark_adaptation	0.99197536
102	MP0003656_abnormal_erythrocyte_physiolo	0.98159767
103	MP0003329_amyloid_beta_deposits	0.96166394
104	MP0005075_abnormal_melanosome_morpholog	0.95601399
105	MP0005408_hypopigmentation	0.95225840
106	MP0005319_abnormal_enzyme/_coenzyme	0.95004208
107	MP0008004_abnormal_stomach_pH	0.94908896
108	MP0000372_irregular_coat_pigmentation	0.94642034
109	MP0005377_hearing/vestibular/ear_phenot	0.93419955
110	MP0003878_abnormal_ear_physiology	0.93419955
111	MP0004947_skin_inflammation	0.91843800
112	MP0005164_abnormal_response_to	0.91382067
113	MP0004264_abnormal_extraembryonic_tissu	0.90359145
114	MP0009763_increased_sensitivity_to	0.89653645
115	MP0000716_abnormal_immune_system	0.88111310
116	MP0005551_abnormal_eye_electrophysiolog	0.87361599
117	MP0002166_altered_tumor_susceptibility	0.86928285
118	MP0000462_abnormal_digestive_system	0.86462606
119	MP0002405_respiratory_system_inflammati	0.86421126
120	MP0009333_abnormal_splenocyte_physiolog	0.85774689
121	MP0005083_abnormal_biliary_tract	0.85096624
122	MP0001346_abnormal_lacrimal_gland	0.84840955
123	MP0005584_abnormal_enzyme/coenzyme_acti	0.84715798
124	MP0005220_abnormal_exocrine_pancreas	0.84497356
125	MP0003448_altered_tumor_morphology	0.83961838
126	MP0001727_abnormal_embryo_implantation	0.83900758
127	MP0006036_abnormal_mitochondrial_physio	0.83351063
128	MP0000609_abnormal_liver_physiology	0.82969447
129	MP0009764_decreased_sensitivity_to	0.82139755
130	MP0000490_abnormal_crypts_of	0.80751805
131	MP0002653_abnormal_ependyma_morphology	0.78559944
132	MP0000358_abnormal_cell_content/	0.77612160
133	MP0003221_abnormal_cardiomyocyte_apopto	0.73457374
134	MP0005397_hematopoietic_system_phenotyp	0.73013251

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of macrophages (HP:0004311)	3.94332983
2	Acute necrotizing encephalopathy (HP:0006965)	3.76877549
3	Elevated erythrocyte sedimentation rate (HP:0003565)	3.76745047
4	Mitochondrial inheritance (HP:0001427)	3.50317941
5	Myositis (HP:0100614)	3.46638056
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.42838277
7	Hepatocellular necrosis (HP:0001404)	3.42833711
8	Recurrent gram-negative bacterial infections (HP:0005420)	3.36868981
9	Irregular epiphyses (HP:0010582)	3.35432001
10	Loss of speech (HP:0002371)	3.34273718
11	Acute encephalopathy (HP:0006846)	3.24748530
12	3-Methylglutaconic aciduria (HP:0003535)	3.21337146
13	Hepatic necrosis (HP:0002605)	3.20400992
14	Abnormal tarsal ossification (HP:0008369)	3.07785491
15	Spontaneous hematomas (HP:0007420)	3.06491231
16	Orchitis (HP:0100796)	3.01900003
17	Renal Fanconi syndrome (HP:0001994)	3.00877377
18	Abnormality of glycolipid metabolism (HP:0010969)	2.98242945
19	Abnormality of liposaccharide metabolism (HP:0010968)	2.98242945
20	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.98242945
21	Progressive macrocephaly (HP:0004481)	2.94031637
22	Retrobulbar optic neuritis (HP:0100654)	2.89260845
23	Optic neuritis (HP:0100653)	2.89260845
24	Increased CSF lactate (HP:0002490)	2.88922195
25	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.84443008
26	Parakeratosis (HP:0001036)	2.80065113
27	Epiphyseal dysplasia (HP:0002656)	2.73340633
28	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.73193692
29	Episodic fever (HP:0001954)	2.67354821
30	Type I transferrin isoform profile (HP:0003642)	2.64838177
31	Small epiphyses (HP:0010585)	2.64539513
32	Increased hepatocellular lipid droplets (HP:0006565)	2.63304615
33	Systemic lupus erythematosus (HP:0002725)	2.63130855
34	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.56591291
35	Reduced antithrombin III activity (HP:0001976)	2.50974423
36	Delayed epiphyseal ossification (HP:0002663)	2.48871622
37	Lipid accumulation in hepatocytes (HP:0006561)	2.48793993
38	Vacuolated lymphocytes (HP:0001922)	2.48119730
39	Beaking of vertebral bodies (HP:0004568)	2.43425742
40	Mutism (HP:0002300)	2.42382819
41	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.42006559
42	Flat capital femoral epiphysis (HP:0003370)	2.38157403
43	Cerebral edema (HP:0002181)	2.37284937
44	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.36890564
45	Hypothermia (HP:0002045)	2.35204473
46	Prolonged partial thromboplastin time (HP:0003645)	2.30649236
47	Chronic obstructive pulmonary disease (HP:0006510)	2.29103722
48	Obstructive lung disease (HP:0006536)	2.29103722
49	Metaphyseal irregularity (HP:0003025)	2.27940198
50	Abnormal protein glycosylation (HP:0012346)	2.27933921
51	Abnormal glycosylation (HP:0012345)	2.27933921
52	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.27933921
53	Abnormal protein N-linked glycosylation (HP:0012347)	2.27933921
54	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.23488940
55	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.23488940
56	Increased serum pyruvate (HP:0003542)	2.22711653
57	Abnormality of glycolysis (HP:0004366)	2.22711653
58	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	2.20124794
59	Anorexia (HP:0002039)	2.18805738
60	Polyphagia (HP:0002591)	2.17979372
61	Abnormality of renal resorption (HP:0011038)	2.16171596
62	Purpura (HP:0000979)	2.15616804
63	Increased serum lactate (HP:0002151)	2.12825374
64	Encephalitis (HP:0002383)	2.12706916
65	Cupped ribs (HP:0000887)	2.12578554
66	Lactic acidosis (HP:0003128)	2.12484088
67	Increased intramyocellular lipid droplets (HP:0012240)	2.11904968
68	Respiratory failure (HP:0002878)	2.11687880
69	Abnormality of the vertebral endplates (HP:0005106)	2.11538169
70	Petechiae (HP:0000967)	2.10423270
71	Optic disc pallor (HP:0000543)	2.10187501
72	Short femoral neck (HP:0100864)	2.10158508
73	Steatorrhea (HP:0002570)	2.09758204
74	Leukodystrophy (HP:0002415)	2.08059575
75	Amyloidosis (HP:0011034)	2.07173794
76	Microretrognathia (HP:0000308)	2.06663905
77	Prolonged neonatal jaundice (HP:0006579)	2.05169776
78	Exertional dyspnea (HP:0002875)	2.05134470
79	Genu varum (HP:0002970)	2.04310504
80	Congenital ichthyosiform erythroderma (HP:0007431)	2.04177725
81	Abolished electroretinogram (ERG) (HP:0000550)	2.03147814
82	Urticaria (HP:0001025)	2.01920872
83	Fat malabsorption (HP:0002630)	2.01110844
84	Generalized aminoaciduria (HP:0002909)	1.99531341
85	Congenital primary aphakia (HP:0007707)	1.99362588
86	Gait imbalance (HP:0002141)	1.98424879
87	CNS demyelination (HP:0007305)	1.96142587
88	Increased cerebral lipofuscin (HP:0011813)	1.95959697
89	Irregular vertebral endplates (HP:0003301)	1.95429252
90	Medial flaring of the eyebrow (HP:0010747)	1.94961449
91	Abnormality of the femoral head (HP:0003368)	1.94880064
92	Vaginal fistula (HP:0004320)	1.94455784
93	Aplasia/hypoplasia of the uterus (HP:0008684)	1.94408982
94	Abnormal respiratory epithelium morphology (HP:0012253)	1.92716384
95	Abnormal respiratory motile cilium morphology (HP:0005938)	1.92716384
96	Sensorimotor neuropathy (HP:0007141)	1.90737577
97	Glycosuria (HP:0003076)	1.90022482
98	Abnormality of urine glucose concentration (HP:0011016)	1.90022482
99	Abnormal foot bone ossification (HP:0010675)	1.89127796
100	Rectovaginal fistula (HP:0000143)	1.89015537
101	Rectal fistula (HP:0100590)	1.89015537
102	Thyroid-stimulating hormone excess (HP:0002925)	1.88605512
103	Intrahepatic cholestasis (HP:0001406)	1.87764641
104	Conjugated hyperbilirubinemia (HP:0002908)	1.87681647
105	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.86752424
106	Disinhibition (HP:0000734)	1.86659225
107	Abnormality of carpal bone ossification (HP:0006257)	1.86511618
108	Recurrent bacterial skin infections (HP:0005406)	1.86210354
109	Mediastinal lymphadenopathy (HP:0100721)	1.85270652
110	Hepatosplenomegaly (HP:0001433)	1.85221475
111	Hyperammonemia (HP:0001987)	1.85070700
112	Recurrent abscess formation (HP:0002722)	1.84805414
113	Increased muscle lipid content (HP:0009058)	1.84784751
114	Abnormality of alanine metabolism (HP:0010916)	1.84518829
115	Hyperalaninemia (HP:0003348)	1.84518829
116	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.84518829
117	Hypoplasia of the uterus (HP:0000013)	1.84501808
118	Lethargy (HP:0001254)	1.83733483
119	Microvesicular hepatic steatosis (HP:0001414)	1.83458892
120	Hypochromic microcytic anemia (HP:0004840)	1.83341792
121	Delayed CNS myelination (HP:0002188)	1.83267162
122	Increased IgM level (HP:0003496)	1.82702433
123	Stenosis of the external auditory canal (HP:0000402)	1.81176339
124	Recurrent skin infections (HP:0001581)	1.80491700
125	Short tibia (HP:0005736)	1.80402632
126	Hypobetalipoproteinemia (HP:0003563)	1.79294308
127	Exercise intolerance (HP:0003546)	1.79291794
128	Pancreatitis (HP:0001733)	1.78658078
129	Abnormality of the epiphysis of the femoral head (HP:0010574)	1.78310810
130	Hematochezia (HP:0002573)	1.78039336
131	Irritability (HP:0000737)	1.76238416
132	Autoamputation (HP:0001218)	1.75713432
133	Flattened epiphyses (HP:0003071)	1.75593812
134	IgM deficiency (HP:0002850)	1.70853313
135	Eczematoid dermatitis (HP:0000976)	1.70684197
136	Barrel-shaped chest (HP:0001552)	1.69687159
137	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.69512427
138	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.69382063
139	Abnormality of serum amino acid levels (HP:0003112)	1.68942470
140	Microcytic anemia (HP:0001935)	1.68374116
141	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	1.68238721
142	Abnormality of femoral epiphyses (HP:0006499)	1.68238721
143	Disproportionate short-trunk short stature (HP:0003521)	1.67008403
144	Abnormality of fatty-acid metabolism (HP:0004359)	1.66979889
145	Hypergammaglobulinemia (HP:0010702)	1.66882905
146	Progressive neurologic deterioration (HP:0002344)	1.66209865
147	Ovoid vertebral bodies (HP:0003300)	1.65696175
148	Patchy hypopigmentation of hair (HP:0011365)	1.65647802
149	Hypokinesia (HP:0002375)	1.65340788
150	Spastic paraparesis (HP:0002313)	1.64827469
151	Pulmonary embolism (HP:0002204)	1.64711341
152	Vasculitis (HP:0002633)	1.64142606
153	Abnormal ciliary motility (HP:0012262)	1.63757582
154	Stomatitis (HP:0010280)	1.63346151
155	Hyperphosphaturia (HP:0003109)	1.60164266
156	Abnormality of the intrinsic pathway (HP:0010989)	1.60049769
157	Nephrogenic diabetes insipidus (HP:0009806)	1.59769138
158	Recurrent pneumonia (HP:0006532)	1.59697049
159	Congenital stationary night blindness (HP:0007642)	1.59541213
160	Abnormal pupillary function (HP:0007686)	1.58600281
161	Cerebral palsy (HP:0100021)	1.58261516

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	3.29035941
2	MST4	3.16864557
3	STK16	2.99310297
4	PIM2	2.56346318
5	STK39	2.43991404
6	CASK	2.41617370
7	MAP3K11	2.30170261
8	TNIK	2.14411409
9	OXSR1	2.10119814
10	ARAF	2.09767907
11	NME1	2.08594425
12	TESK1	2.05151986
13	IRAK4	2.01724729
14	NME2	2.01240553
15	PBK	1.94742988
16	ADRBK2	1.83481433
17	TXK	1.80784807
18	MAP3K12	1.76849578
19	BLK	1.75697898
20	MAP3K14	1.74502093
21	BMPR2	1.67794824
22	MYLK	1.58735300
23	EPHB1	1.57580983
24	MUSK	1.55231881
25	EIF2AK3	1.53813404
26	ERN1	1.52474195
27	GRK6	1.51941724
28	GRK1	1.51709086
29	MAP2K3	1.49581827
30	IRAK3	1.48781988
31	DYRK3	1.46510867
32	NLK	1.39041502
33	TIE1	1.37979705
34	MAP3K6	1.37474974
35	MAP3K5	1.32183216
36	MAPK15	1.30978793
37	BMPR1B	1.30012464
38	EIF2AK1	1.27973751
39	BCKDK	1.25640702
40	VRK1	1.25056625
41	RIPK4	1.23166712
42	TEC	1.22578884
43	CDK19	1.21543813
44	TESK2	1.19811161
45	PAK4	1.17434679
46	BRAF	1.15883571
47	MAPKAPK3	1.12923849
48	TYK2	1.12555814
49	MAPKAPK5	1.11738532
50	ERBB3	1.11404350
51	BUB1	1.10975821
52	MST1R	1.09418340
53	WNK4	1.07084493
54	MAP2K4	1.05770625
55	TAOK3	1.05725673
56	BCR	1.05557813
57	NUAK1	1.04461163
58	DAPK1	1.04111888
59	PIK3CG	1.03879211
60	KIT	1.03100559
61	IKBKE	1.02031994
62	ACVR1B	1.01154225
63	PINK1	0.99541014
64	IRAK1	0.99061208
65	INSRR	0.95827103
66	NEK6	0.94269265
67	SRPK1	0.92156028
68	IKBKB	0.91913853
69	DYRK2	0.90846985
70	CSNK1G3	0.88510118
71	FER	0.88097823
72	TGFBR2	0.87936439
73	EIF2AK2	0.84576632
74	SYK	0.83649468
75	ZAK	0.82599099
76	CDK3	0.80209890
77	KSR1	0.80183716
78	LRRK2	0.80068548
79	MAP4K1	0.79680967
80	CCNB1	0.79249595
81	BTK	0.79208171
82	MAP2K7	0.76814051
83	LYN	0.76735486
84	FES	0.76396562
85	MAP2K2	0.75479384
86	YES1	0.74828121
87	ZAP70	0.74566031
88	LIMK1	0.74538722
89	STK10	0.74452647
90	PRKCE	0.74278509
91	CAMK2B	0.73336788
92	TBK1	0.73179479
93	GRK7	0.72858491
94	PRKCQ	0.72240849
95	VRK2	0.70430071
96	RPS6KA5	0.69285085
97	WNK3	0.68662517
98	CDK8	0.68585005
99	CSNK1G2	0.68254524
100	FGR	0.67799634
101	CAMK2G	0.67461118
102	CSNK1G1	0.65573454
103	TAOK1	0.64810923
104	ABL2	0.64492885
105	CAMK2D	0.63991560
106	LCK	0.62656267
107	STK24	0.62398863
108	PRKG2	0.61688377
109	IRAK2	0.61479002
110	CSF1R	0.60932234
111	AKT3	0.60135484
112	PKN1	0.59435252
113	JAK2	0.59165293
114	MAP3K3	0.58530523
115	ERBB4	0.58471544
116	SIK3	0.57406142
117	PDK2	0.56296969
118	MAPKAPK2	0.54461808
119	GRK5	0.53919067
120	EPHA3	0.53572784
121	MAP3K1	0.53081238
122	MATK	0.53055930
123	TNK2	0.52721241
124	HCK	0.52235527
125	MKNK1	0.52161719
126	MAP2K6	0.52014437
127	MINK1	0.51030032
128	PRKCI	0.50681956
129	JAK1	0.50482138
130	CSNK1A1L	0.49004779
131	MET	0.48597271
132	CSK	0.48134069
133	MAPK4	0.47018231
134	MAP3K4	0.46931325
135	PRKCD	0.46748365
136	MKNK2	0.45664252
137	ITK	0.44254403
138	JAK3	0.43952055
139	MAP4K2	0.41937850
140	ALK	0.41830592

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.58848795
2	Sulfur metabolism_Homo sapiens_hsa00920	3.38996982
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.19548301
4	Fatty acid elongation_Homo sapiens_hsa00062	2.61136768
5	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.44621819
6	Parkinsons disease_Homo sapiens_hsa05012	2.33179778
7	Proteasome_Homo sapiens_hsa03050	2.23522611
8	Steroid biosynthesis_Homo sapiens_hsa00100	2.17425543
9	Histidine metabolism_Homo sapiens_hsa00340	2.16118089
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.96614181
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.91816941
12	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.88302820
13	Folate biosynthesis_Homo sapiens_hsa00790	1.84903598
14	Alzheimers disease_Homo sapiens_hsa05010	1.83921591
15	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.76970971
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.71171743
17	Ribosome_Homo sapiens_hsa03010	1.70822529
18	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.69449281
19	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.68181785
20	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.62843783
21	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.60115922
22	Chemical carcinogenesis_Homo sapiens_hsa05204	1.52583055
23	Sphingolipid metabolism_Homo sapiens_hsa00600	1.49936487
24	Legionellosis_Homo sapiens_hsa05134	1.49183256
25	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.45254721
26	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.43862317
27	Huntingtons disease_Homo sapiens_hsa05016	1.43166760
28	RNA polymerase_Homo sapiens_hsa03020	1.41376444
29	Ether lipid metabolism_Homo sapiens_hsa00565	1.38105865
30	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.36989577
31	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.35202043
32	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.34777307
33	Peroxisome_Homo sapiens_hsa04146	1.34738217
34	Sulfur relay system_Homo sapiens_hsa04122	1.31529655
35	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.30731574
36	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.29975075
37	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.29371054
38	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.28942521
39	Other glycan degradation_Homo sapiens_hsa00511	1.28550928
40	Glutathione metabolism_Homo sapiens_hsa00480	1.26004279
41	Collecting duct acid secretion_Homo sapiens_hsa04966	1.23618702
42	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.21388501
43	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.20606814
44	Retinol metabolism_Homo sapiens_hsa00830	1.19580104
45	Rheumatoid arthritis_Homo sapiens_hsa05323	1.17360225
46	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.16957341
47	Linoleic acid metabolism_Homo sapiens_hsa00591	1.14937894
48	Tuberculosis_Homo sapiens_hsa05152	1.13734158
49	Butanoate metabolism_Homo sapiens_hsa00650	1.12483384
50	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.12436279
51	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.12019027
52	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.11505246
53	Graft-versus-host disease_Homo sapiens_hsa05332	1.10920311
54	Salmonella infection_Homo sapiens_hsa05132	1.10258054
55	Primary immunodeficiency_Homo sapiens_hsa05340	1.09365633
56	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.08282349
57	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.07272903
58	Phototransduction_Homo sapiens_hsa04744	1.06843923
59	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.06424170
60	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.06367333
61	Galactose metabolism_Homo sapiens_hsa00052	1.04227448
62	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.03101007
63	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.03093677
64	Arginine and proline metabolism_Homo sapiens_hsa00330	1.02107241
65	Leishmaniasis_Homo sapiens_hsa05140	1.00888785
66	Regulation of autophagy_Homo sapiens_hsa04140	0.99872217
67	beta-Alanine metabolism_Homo sapiens_hsa00410	0.98725954
68	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.96886449
69	Osteoclast differentiation_Homo sapiens_hsa04380	0.96121345
70	Metabolic pathways_Homo sapiens_hsa01100	0.95828181
71	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.95389084
72	Phenylalanine metabolism_Homo sapiens_hsa00360	0.94120278
73	Shigellosis_Homo sapiens_hsa05131	0.93929461
74	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.93447342
75	Vibrio cholerae infection_Homo sapiens_hsa05110	0.93411096
76	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.92137019
77	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.90441868
78	Allograft rejection_Homo sapiens_hsa05330	0.90334430
79	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.89589216
80	Pertussis_Homo sapiens_hsa05133	0.86438267
81	Tyrosine metabolism_Homo sapiens_hsa00350	0.85781887
82	Tryptophan metabolism_Homo sapiens_hsa00380	0.79047545
83	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.77674754
84	Pyruvate metabolism_Homo sapiens_hsa00620	0.77517030
85	Pyrimidine metabolism_Homo sapiens_hsa00240	0.76829945
86	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.73734060
87	Lysosome_Homo sapiens_hsa04142	0.73101425
88	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.73100316
89	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.71111819
90	ABC transporters_Homo sapiens_hsa02010	0.70925712
91	Complement and coagulation cascades_Homo sapiens_hsa04610	0.70109451
92	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.70104399
93	Malaria_Homo sapiens_hsa05144	0.68248692
94	Asthma_Homo sapiens_hsa05310	0.67188317
95	Propanoate metabolism_Homo sapiens_hsa00640	0.67093380
96	Type I diabetes mellitus_Homo sapiens_hsa04940	0.66656188
97	Phagosome_Homo sapiens_hsa04145	0.66031995
98	Carbon metabolism_Homo sapiens_hsa01200	0.62959276
99	Fatty acid degradation_Homo sapiens_hsa00071	0.61807241
100	Purine metabolism_Homo sapiens_hsa00230	0.56547823
101	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.56005557
102	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.55750764
103	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.55492307
104	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.55426766
105	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.53684090
106	Mineral absorption_Homo sapiens_hsa04978	0.52485475
107	Pentose phosphate pathway_Homo sapiens_hsa00030	0.51647322
108	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.50988995
109	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.50891120
110	Fatty acid metabolism_Homo sapiens_hsa01212	0.50582274
111	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.47599228
112	PPAR signaling pathway_Homo sapiens_hsa03320	0.46759528
113	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.45193214
114	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.44975412
115	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.43563642
116	Antigen processing and presentation_Homo sapiens_hsa04612	0.42540253
117	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.42105275
118	Fat digestion and absorption_Homo sapiens_hsa04975	0.42059596
119	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.41743357
120	Caffeine metabolism_Homo sapiens_hsa00232	0.37901259
121	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.33133043
122	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.32996946
123	African trypanosomiasis_Homo sapiens_hsa05143	0.32897007

YIPF1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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