YIPF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.32049155
2L-phenylalanine metabolic process (GO:0006558)5.32049155
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.11268362
4L-phenylalanine catabolic process (GO:0006559)5.11268362
5protein maturation by protein folding (GO:0022417)4.79903970
6retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.42562416
7cysteine metabolic process (GO:0006534)4.41246860
8sulfur amino acid catabolic process (GO:0000098)4.37838674
9protein retention in ER lumen (GO:0006621)4.18517977
10Golgi transport vesicle coating (GO:0048200)4.17134120
11COPI coating of Golgi vesicle (GO:0048205)4.17134120
12maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.02654990
13protein carboxylation (GO:0018214)4.00549378
14peptidyl-glutamic acid carboxylation (GO:0017187)4.00549378
15aromatic amino acid family catabolic process (GO:0009074)4.00178726
16ethanol oxidation (GO:0006069)3.87035468
17glyoxylate metabolic process (GO:0046487)3.86731542
18triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.77534449
19negative regulation of fibrinolysis (GO:0051918)3.75130404
20extracellular fibril organization (GO:0043206)3.70050326
21type B pancreatic cell proliferation (GO:0044342)3.68573073
22alpha-linolenic acid metabolic process (GO:0036109)3.63461919
23barbed-end actin filament capping (GO:0051016)3.61622834
24lysine catabolic process (GO:0006554)3.49966076
25lysine metabolic process (GO:0006553)3.49966076
26valine metabolic process (GO:0006573)3.49448569
27intestinal cholesterol absorption (GO:0030299)3.46387322
28bile acid biosynthetic process (GO:0006699)3.45502857
29negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.43363166
30regulation of fibrinolysis (GO:0051917)3.39013006
31amino-acid betaine metabolic process (GO:0006577)3.38796740
32fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.34042181
334-hydroxyproline metabolic process (GO:0019471)3.33430019
34short-chain fatty acid metabolic process (GO:0046459)3.30046313
35cellular modified amino acid catabolic process (GO:0042219)3.28967810
36regulation of extracellular matrix disassembly (GO:0010715)3.26034187
37vesicle coating (GO:0006901)3.18948412
38signal peptide processing (GO:0006465)3.18230056
39virion assembly (GO:0019068)3.16861787
40regulation of cholesterol homeostasis (GO:2000188)3.16857895
41kynurenine metabolic process (GO:0070189)3.14869393
42regulation of protein activation cascade (GO:2000257)3.13670721
43serine family amino acid biosynthetic process (GO:0009070)3.13229153
44fibril organization (GO:0097435)3.13096384
45fatty acid beta-oxidation (GO:0006635)3.12475321
46high-density lipoprotein particle remodeling (GO:0034375)3.09224746
47fatty acid catabolic process (GO:0009062)3.09068092
48aromatic amino acid family metabolic process (GO:0009072)3.05563828
49serine family amino acid metabolic process (GO:0009069)3.05199265
50regulation of autophagic vacuole assembly (GO:2000785)3.04638194
51tryptophan catabolic process (GO:0006569)3.04154355
52indole-containing compound catabolic process (GO:0042436)3.04154355
53indolalkylamine catabolic process (GO:0046218)3.04154355
54fatty acid oxidation (GO:0019395)3.03316582
55regulation of complement activation (GO:0030449)3.00853030
56lipid oxidation (GO:0034440)2.98574926
57plasma lipoprotein particle clearance (GO:0034381)2.97195012
58positive regulation of triglyceride metabolic process (GO:0090208)2.96435021
59serine family amino acid catabolic process (GO:0009071)2.96062890
60complement activation, alternative pathway (GO:0006957)2.95494986
61branched-chain amino acid catabolic process (GO:0009083)2.94886472
62positive regulation of triglyceride biosynthetic process (GO:0010867)2.94302653
63opsonization (GO:0008228)2.94217705
64regulation of cholesterol metabolic process (GO:0090181)2.94120449
65ethanol metabolic process (GO:0006067)2.92766010
66monocarboxylic acid catabolic process (GO:0072329)2.92651436
67tryptophan metabolic process (GO:0006568)2.92516801
68response to nitrosative stress (GO:0051409)2.92269133
69COPII vesicle coating (GO:0048208)2.92197805
70positive regulation of triglyceride lipase activity (GO:0061365)2.92085337
71positive regulation of lipoprotein lipase activity (GO:0051006)2.92085337
72cellular copper ion homeostasis (GO:0006878)2.91219546
73aspartate family amino acid catabolic process (GO:0009068)2.89727586
74branched-chain amino acid metabolic process (GO:0009081)2.89479638
75carnitine metabolic process (GO:0009437)2.89440254
76coenzyme catabolic process (GO:0009109)2.88799688
77regulation of metalloenzyme activity (GO:0048552)2.88470149
78GDP-mannose metabolic process (GO:0019673)2.88183381
79regulation of cholesterol esterification (GO:0010872)2.88100144
80amyloid precursor protein catabolic process (GO:0042987)2.88009299
81glycine metabolic process (GO:0006544)2.87260332
82cellular ketone body metabolic process (GO:0046950)2.86844028
83bile acid metabolic process (GO:0008206)2.86253895
84aldehyde catabolic process (GO:0046185)2.86014155
85cellular amino acid catabolic process (GO:0009063)2.85402999
86regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.85292709
87alpha-amino acid catabolic process (GO:1901606)2.84910035
88basement membrane organization (GO:0071711)2.84133418
89regulation of triglyceride catabolic process (GO:0010896)2.83933891
90eosinophil chemotaxis (GO:0048245)2.82865198
91homocysteine metabolic process (GO:0050667)2.82288578
92positive regulation of fatty acid biosynthetic process (GO:0045723)2.79995560
93organic acid catabolic process (GO:0016054)2.78008250
94carboxylic acid catabolic process (GO:0046395)2.78008250
95regulation of plasminogen activation (GO:0010755)2.77030271
96ER to Golgi vesicle-mediated transport (GO:0006888)2.76800283
97heme transport (GO:0015886)2.76675665
98skin morphogenesis (GO:0043589)2.76339035
99exocrine pancreas development (GO:0031017)2.74904536
100regulation of amyloid precursor protein catabolic process (GO:1902991)2.74787999
101response to mercury ion (GO:0046689)2.74545824
102regulation of vacuole organization (GO:0044088)2.73061477
103acute-phase response (GO:0006953)2.72387044
104L-serine metabolic process (GO:0006563)2.69724826
105regulation of mononuclear cell migration (GO:0071675)2.69628082
106plasma lipoprotein particle remodeling (GO:0034369)2.69146728
107protein-lipid complex remodeling (GO:0034368)2.69146728
108macromolecular complex remodeling (GO:0034367)2.69146728
109positive regulation of TOR signaling (GO:0032008)2.68979781
110pentose-phosphate shunt (GO:0006098)2.68351044
111fibrinolysis (GO:0042730)2.67929953
112antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.66993641
113antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.66993641
114peptidyl-proline hydroxylation (GO:0019511)2.66566758
115activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.66488136
116primary alcohol catabolic process (GO:0034310)2.65821212
117negative regulation of cholesterol transport (GO:0032375)2.65799418
118negative regulation of sterol transport (GO:0032372)2.65799418
119reverse cholesterol transport (GO:0043691)2.65733574
120biotin metabolic process (GO:0006768)2.65644653
121endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.65298653
122tyrosine metabolic process (GO:0006570)2.64648258
123ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.61924863
124cofactor catabolic process (GO:0051187)2.61782979
125tricarboxylic acid metabolic process (GO:0072350)2.61466926
1262-oxoglutarate metabolic process (GO:0006103)2.60915059
127L-serine transport (GO:0015825)2.59475166
128proline biosynthetic process (GO:0006561)2.58123764
129regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.57341051
130regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.52819074
131regulation of integrin-mediated signaling pathway (GO:2001044)2.51998831
132glucose 6-phosphate metabolic process (GO:0051156)2.51551177
133actin filament depolymerization (GO:0030042)2.51267178
134positive regulation of pseudopodium assembly (GO:0031274)2.50339904
135glucose catabolic process (GO:0006007)2.49528939
136NADPH regeneration (GO:0006740)2.48909650
137eosinophil migration (GO:0072677)2.47982867
138viral protein processing (GO:0019082)2.46696040
139lipopolysaccharide biosynthetic process (GO:0009103)2.46640284
140protein insertion into membrane (GO:0051205)2.46272083
141positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.45507342
142positive regulation of mitochondrial fission (GO:0090141)2.45234447
143serine transport (GO:0032329)2.42213774
144fatty acid elongation (GO:0030497)2.42101812
145response to gravity (GO:0009629)2.36102627
146ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.32481864
147nucleoside bisphosphate biosynthetic process (GO:0033866)2.32481864
148purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.32481864
149regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.32036699
150ganglion development (GO:0061548)2.29805966
151galactose catabolic process (GO:0019388)2.29541255
152cell adhesion mediated by integrin (GO:0033627)2.28869233
153negative regulation of glycoprotein metabolic process (GO:1903019)2.27691841
154ATP hydrolysis coupled proton transport (GO:0015991)2.27553155
155energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.27553155
156positive regulation of actin filament depolymerization (GO:0030836)2.27382417
157protein hydroxylation (GO:0018126)2.27112690
158positive regulation of Rho protein signal transduction (GO:0035025)2.26527780
159maintenance of protein localization in organelle (GO:0072595)2.23314345
160transferrin transport (GO:0033572)2.23287983
161membrane budding (GO:0006900)2.23094838
162phagosome maturation (GO:0090382)2.21846956
163amino sugar catabolic process (GO:0046348)2.20677898
164protein localization to endosome (GO:0036010)2.20022480
165positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.17988440
166proteasome assembly (GO:0043248)2.16038462
167regulation of pseudopodium assembly (GO:0031272)2.14121406
168positive regulation of nuclease activity (GO:0032075)2.13557185
169morphogenesis of an endothelium (GO:0003159)2.12961903
170endothelial tube morphogenesis (GO:0061154)2.12961903
171peptidyl-arginine omega-N-methylation (GO:0035247)2.11279792
172beta-amyloid metabolic process (GO:0050435)2.10803345
173negative regulation of Ras GTPase activity (GO:0034261)2.10457964
174galactose metabolic process (GO:0006012)2.09305272
175negative regulation of smooth muscle cell migration (GO:0014912)2.09016819
176platelet degranulation (GO:0002576)2.08144038
177muscle cell migration (GO:0014812)2.07412620
178metallo-sulfur cluster assembly (GO:0031163)2.06343160
179iron-sulfur cluster assembly (GO:0016226)2.06343160
180monosaccharide biosynthetic process (GO:0046364)2.06045637

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.46406966
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.52852249
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.31411647
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.13594581
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.15913664
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.89481170
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.85009793
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.69723985
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.60428832
10EGR1_23403033_ChIP-Seq_LIVER_Mouse2.53221958
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.17629710
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15202651
13LXR_22292898_ChIP-Seq_THP-1_Human2.07739529
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.95065158
15IRF8_22096565_ChIP-ChIP_GC-B_Human1.91924536
16CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.86754192
17TRIM28_21343339_ChIP-Seq_HEK293_Human1.86113471
18CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.84728261
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.84515191
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.84240891
21CLOCK_20551151_ChIP-Seq_293T_Human1.84035134
22HIF1A_21447827_ChIP-Seq_MCF-7_Human1.82533955
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.68404767
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65109021
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63349220
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.63260705
27ELK3_25401928_ChIP-Seq_HUVEC_Human1.61309356
28CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.61085968
29NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.58384655
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.53712080
31ZNF263_19887448_ChIP-Seq_K562_Human1.48996404
32RACK7_27058665_Chip-Seq_MCF-7_Human1.48486125
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.47730883
34DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.47193594
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.46461988
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.45086965
37VDR_21846776_ChIP-Seq_THP-1_Human1.43875207
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43410649
39CTCF_18555785_ChIP-Seq_MESCs_Mouse1.42594009
40NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.42327157
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.42187189
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.41657224
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.41435114
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.39858039
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.39217564
46ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34310161
47HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.31671465
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30050550
49KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28466256
50GABP_19822575_ChIP-Seq_HepG2_Human1.28209807
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27902163
52ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27901586
53DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24640139
54TP53_22127205_ChIP-Seq_IMR90_Human1.24320791
55SA1_27219007_Chip-Seq_ERYTHROID_Human1.23907570
56DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.23824460
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.22902504
58SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20657590
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20015900
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19685354
61ATF3_27146783_Chip-Seq_COLON_Human1.18184866
62RARB_24833708_ChIP-Seq_LIVER_Mouse1.16459143
63TET1_21451524_ChIP-Seq_MESCs_Mouse1.16070952
64SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14496369
65GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14131695
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13717588
67SMC1_22415368_ChIP-Seq_MEFs_Mouse1.13629132
68* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13491196
69TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.12843720
70NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.12758958
71MYC_22102868_ChIP-Seq_BL_Human1.12533272
72P63_26484246_Chip-Seq_KERATINOCYTES_Human1.11703025
73ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11543713
74SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.11254693
75CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10522513
76RARA_24833708_ChIP-Seq_LIVER_Mouse1.10478793
77* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09350086
78ELF1_17652178_ChIP-ChIP_JURKAT_Human1.07235888
79PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.07170332
80* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06789604
81* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05298859
82BCOR_27268052_Chip-Seq_Bcells_Human1.05213997
83* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.04754181
84GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04367326
85YY1_21170310_ChIP-Seq_MESCs_Mouse1.03844198
86TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.03830881
87CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03462757
88FOXP1_21924763_ChIP-Seq_HESCs_Human1.02940412
89YY1_22570637_ChIP-Seq_MALME-3M_Human1.02924524
90TET1_21490601_ChIP-Seq_MESCs_Mouse1.02702346
91SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.02180286
92MAF_26560356_Chip-Seq_TH1_Human1.01795214
93NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01721859
94ELF1_20517297_ChIP-Seq_JURKAT_Human1.01703233
95P68_20966046_ChIP-Seq_HELA_Human1.01579844
96* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.00884691
97CTCF_20526341_ChIP-Seq_ESCs_Human1.00228014
98VDR_24763502_ChIP-Seq_THP-1_Human1.00203613
99PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99490226
100BCL6_27268052_Chip-Seq_Bcells_Human0.98962564
101CTCF_21964334_Chip-Seq_Bcells_Human0.98653146
102ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98451404
103UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98201873
104CSB_26484114_Chip-Seq_FIBROBLAST_Human0.97004817
105MAF_26560356_Chip-Seq_TH2_Human0.96513977
106HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96455884
107RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96350427
108MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.96154161
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94765547
110BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94637198
111SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94625183
112MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.93394326
113SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92750076
114PHF8_20622854_ChIP-Seq_HELA_Human0.92701995
115IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92558146
116JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92423282
117SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.92173138
118SA1_27219007_Chip-Seq_Bcells_Human0.91074716
119KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88972910
120TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88467361
121ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87457469
122* GABP_17652178_ChIP-ChIP_JURKAT_Human0.87374907
123SOX2_20726797_ChIP-Seq_SW620_Human0.87347913
124LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87088241
125MYB_21317192_ChIP-Seq_ERMYB_Mouse0.86956275
126NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.86835610
127RAD21_21589869_ChIP-Seq_MESCs_Mouse0.86346905
128ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.86063118
129SMC3_22415368_ChIP-Seq_MEFs_Mouse0.85596655
130GATA4_25053715_ChIP-Seq_YYC3_Human0.85318392
131UTX_26944678_Chip-Seq_JUKART_Human0.85194568
132CTCF_21964334_ChIP-Seq_BJAB-B_Human0.84786431
133* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84090216
134MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.83640644
135E2F1_18555785_ChIP-Seq_MESCs_Mouse0.83447849
136KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.82777270
137KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.82734349
138ETS1_20019798_ChIP-Seq_JURKAT_Human0.81439382
139SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.81267987
140STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81099560

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.34214818
2MP0009840_abnormal_foam_cell4.55997182
3MP0005365_abnormal_bile_salt3.97517667
4MP0005360_urolithiasis3.96360523
5MP0005085_abnormal_gallbladder_physiolo3.19685083
6MP0008438_abnormal_cutaneous_collagen3.18522696
7MP0003806_abnormal_nucleotide_metabolis3.04540245
8MP0005257_abnormal_intraocular_pressure2.80984015
9MP0008875_abnormal_xenobiotic_pharmacok2.77428039
10MP0005083_abnormal_biliary_tract2.72592018
11MP0003122_maternal_imprinting2.71883772
12MP0001666_abnormal_nutrient_absorption2.61428743
13MP0003195_calcinosis2.52997736
14MP0000566_synostosis2.40014629
15MP0008260_abnormal_autophagy2.20587927
16MP0005332_abnormal_amino_acid2.19675817
17MP0003172_abnormal_lysosome_physiology2.15525261
18MP0003252_abnormal_bile_duct2.11025631
19MP0009780_abnormal_chondrocyte_physiolo2.07157999
20MP0010329_abnormal_lipoprotein_level1.98346149
21MP0003191_abnormal_cellular_cholesterol1.96262609
22MP0005220_abnormal_exocrine_pancreas1.95794383
23MP0010030_abnormal_orbit_morphology1.84094702
24MP0003300_gastrointestinal_ulcer1.81974767
25MP0005058_abnormal_lysosome_morphology1.80563934
26MP0009643_abnormal_urine_homeostasis1.79873322
27MP0002653_abnormal_ependyma_morphology1.72632783
28MP0003705_abnormal_hypodermis_morpholog1.68365169
29MP0000609_abnormal_liver_physiology1.58979831
30MP0002138_abnormal_hepatobiliary_system1.58284276
31MP0002118_abnormal_lipid_homeostasis1.56792553
32MP0000751_myopathy1.56400144
33MP0003724_increased_susceptibility_to1.55906605
34MP0005171_absent_coat_pigmentation1.52814890
35MP0004510_myositis1.51423971
36MP0005451_abnormal_body_composition1.51195828
37MP0003279_aneurysm1.51027832
38MP0004019_abnormal_vitamin_homeostasis1.48333749
39MP0005275_abnormal_skin_tensile1.48224571
40MP0005584_abnormal_enzyme/coenzyme_acti1.46603249
41MP0003186_abnormal_redox_activity1.45836667
42MP0005319_abnormal_enzyme/_coenzyme1.43674019
43MP0005367_renal/urinary_system_phenotyp1.43538479
44MP0000516_abnormal_urinary_system1.43538479
45MP0003011_delayed_dark_adaptation1.43224930
46MP0003123_paternal_imprinting1.41326889
47MP0003868_abnormal_feces_composition1.41235387
48MP0009384_cardiac_valve_regurgitation1.38053678
49MP0004858_abnormal_nervous_system1.36533541
50MP0001849_ear_inflammation1.35830907
51MP0001542_abnormal_bone_strength1.31503374
52MP0003656_abnormal_erythrocyte_physiolo1.31263645
53MP0005636_abnormal_mineral_homeostasis1.26104569
54MP0003075_altered_response_to1.26008427
55MP0002837_dystrophic_cardiac_calcinosis1.23783505
56MP0004043_abnormal_pH_regulation1.23770210
57MP0003436_decreased_susceptibility_to1.20623997
58MP0001958_emphysema1.18794461
59MP0006054_spinal_hemorrhage1.18553949
60MP0004133_heterotaxia1.16481545
61MP0005508_abnormal_skeleton_morphology1.15692382
62MP0000534_abnormal_ureter_morphology1.15344198
63MP0002877_abnormal_melanocyte_morpholog1.13262761
64MP0001756_abnormal_urination1.12020352
65MP0005503_abnormal_tendon_morphology1.10902569
66MP0000538_abnormal_urinary_bladder1.10625644
67MP0001944_abnormal_pancreas_morphology1.09764425
68MP0002933_joint_inflammation1.09549984
69MP0001905_abnormal_dopamine_level1.08173338
70MP0008469_abnormal_protein_level1.07940134
71MP0005084_abnormal_gallbladder_morpholo1.06848416
72MP0010368_abnormal_lymphatic_system1.05537350
73MP0000685_abnormal_immune_system1.04857170
74MP0001533_abnormal_skeleton_physiology1.04703554
75MP0005623_abnormal_meninges_morphology1.04517083
76MP0003942_abnormal_urinary_system1.04118217
77MP0008789_abnormal_olfactory_epithelium1.02432717
78MP0005408_hypopigmentation1.02315059
79MP0005464_abnormal_platelet_physiology1.01844999
80MP0006036_abnormal_mitochondrial_physio1.01169041
81MP0005390_skeleton_phenotype1.00904410
82MP0000598_abnormal_liver_morphology0.99600170
83MP0000767_abnormal_smooth_muscle0.95722197
84MP0003183_abnormal_peptide_metabolism0.95608044
85MP0002060_abnormal_skin_morphology0.94839094
86MP0005023_abnormal_wound_healing0.94325762
87MP0001299_abnormal_eye_distance/0.93175035
88MP0001915_intracranial_hemorrhage0.93055305
89MP0001529_abnormal_vocalization0.92736574
90MP0003566_abnormal_cell_adhesion0.92351231
91MP0000750_abnormal_muscle_regeneration0.92269195
92MP0009764_decreased_sensitivity_to0.91842692
93MP0001764_abnormal_homeostasis0.91758862
94MP0002736_abnormal_nociception_after0.91486663
95MP0010386_abnormal_urinary_bladder0.89915862
96MP0001270_distended_abdomen0.89143059
97MP0005164_abnormal_response_to0.88736106
98MP0006082_CNS_inflammation0.87926004
99MP0005165_increased_susceptibility_to0.86821034
100MP0000681_abnormal_thyroid_gland0.86601950
101MP0009379_abnormal_foot_pigmentation0.86052794
102MP0000013_abnormal_adipose_tissue0.86045376
103MP0005670_abnormal_white_adipose0.85941232
104MP0003329_amyloid_beta_deposits0.85102806
105MP0004264_abnormal_extraembryonic_tissu0.85079007
106MP0009785_altered_susceptibility_to0.84451372
107MP0000858_altered_metastatic_potential0.84414165
108MP0003283_abnormal_digestive_organ0.83689044
109MP0001765_abnormal_ion_homeostasis0.83500500
110MP0003121_genomic_imprinting0.83065300
111MP0001243_abnormal_dermal_layer0.82594288
112MP0009763_increased_sensitivity_to0.81789183
113MP0003221_abnormal_cardiomyocyte_apopto0.81724106
114MP0000604_amyloidosis0.81228905
115MP0001845_abnormal_inflammatory_respons0.80877156
116MP0004272_abnormal_basement_membrane0.80865152
117MP0002078_abnormal_glucose_homeostasis0.80630627
118MP0009642_abnormal_blood_homeostasis0.79788608
119MP0003879_abnormal_hair_cell0.78085904
120MP0002693_abnormal_pancreas_physiology0.77781695
121MP0005666_abnormal_adipose_tissue0.77431381
122MP0010155_abnormal_intestine_physiology0.77280101
123MP0004130_abnormal_muscle_cell0.76405303
124MP0005375_adipose_tissue_phenotype0.75087857
125MP0002136_abnormal_kidney_physiology0.74576523
126MP0002295_abnormal_pulmonary_circulatio0.74426018
127MP0004185_abnormal_adipocyte_glucose0.73658662
128MP0003303_peritoneal_inflammation0.73519565
129MP0005166_decreased_susceptibility_to0.73331388
130MP0000467_abnormal_esophagus_morphology0.72041739
131MP0000613_abnormal_salivary_gland0.71907881
132MP0009333_abnormal_splenocyte_physiolog0.71891222
133MP0005197_abnormal_uvea_morphology0.71433706
134MP0001663_abnormal_digestive_system0.70975576
135MP0004270_analgesia0.70640080
136MP0002822_catalepsy0.69854729
137MP0000343_altered_response_to0.68595184
138MP0002254_reproductive_system_inflammat0.68461461
139MP0002277_abnormal_respiratory_mucosa0.68064529
140MP0001790_abnormal_immune_system0.67902223
141MP0005387_immune_system_phenotype0.67902223
142MP0005025_abnormal_response_to0.67710434
143MP0002089_abnormal_postnatal_growth/wei0.66929965
144MP0002796_impaired_skin_barrier0.66674405
145MP0002751_abnormal_autonomic_nervous0.66237316
146MP0004947_skin_inflammation0.66001594
147MP0005595_abnormal_vascular_smooth0.65935682
148MP0005381_digestive/alimentary_phenotyp0.65544107
149MP0002876_abnormal_thyroid_physiology0.65107451
150MP0003634_abnormal_glial_cell0.63604717
151MP0000358_abnormal_cell_content/0.63483307
152MP0003959_abnormal_lean_body0.63450735
153MP0002909_abnormal_adrenal_gland0.61995774
154MP0000003_abnormal_adipose_tissue0.61648839
155MP0005501_abnormal_skin_physiology0.58299558
156MP0002896_abnormal_bone_mineralization0.57662993

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.37182118
2Xanthomatosis (HP:0000991)4.23667514
3Hand muscle atrophy (HP:0009130)4.01888410
4Hypoglycemic coma (HP:0001325)3.88624343
5Deep venous thrombosis (HP:0002625)3.87014320
6Protrusio acetabuli (HP:0003179)3.76222082
7Cutaneous melanoma (HP:0012056)3.69634181
8Hyperlipoproteinemia (HP:0010980)3.68315874
9Cervical subluxation (HP:0003308)3.62530282
10Abnormality of monocarboxylic acid metabolism (HP:0010996)3.59384797
11Distal upper limb amyotrophy (HP:0007149)3.54542969
12Upper limb amyotrophy (HP:0009129)3.54542969
13Abnormal gallbladder physiology (HP:0012438)3.50541373
14Cholecystitis (HP:0001082)3.50541373
15Ketosis (HP:0001946)3.47784136
16Intrahepatic cholestasis (HP:0001406)3.43003935
17Premature rupture of membranes (HP:0001788)3.42497967
18Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.29137937
19Ketoacidosis (HP:0001993)3.23595584
20Abnormality of fatty-acid metabolism (HP:0004359)3.22641344
21Vacuolated lymphocytes (HP:0001922)3.19977852
22Late onset (HP:0003584)3.14761042
23Prolonged partial thromboplastin time (HP:0003645)3.10665548
24Prolonged neonatal jaundice (HP:0006579)3.06307015
25Hyperammonemia (HP:0001987)3.00634880
26Dysostosis multiplex (HP:0000943)2.95006089
27Hyperglycinuria (HP:0003108)2.93911617
28J-shaped sella turcica (HP:0002680)2.85493618
29Abnormality of serine family amino acid metabolism (HP:0010894)2.83676999
30Abnormality of glycine metabolism (HP:0010895)2.83676999
31Vertebral compression fractures (HP:0002953)2.75039463
32Abnormality of the intrinsic pathway (HP:0010989)2.70852442
33Abnormality of the common coagulation pathway (HP:0010990)2.70700690
34Abnormality of dentin (HP:0010299)2.70394748
35Abnormality of glutamine family amino acid metabolism (HP:0010902)2.69696785
36Abnormality of liposaccharide metabolism (HP:0010968)2.68458362
37Abnormality of glycosphingolipid metabolism (HP:0004343)2.68458362
38Abnormality of glycolipid metabolism (HP:0010969)2.68458362
39Hypobetalipoproteinemia (HP:0003563)2.66428538
40Hyperglycinemia (HP:0002154)2.66111792
41Short nail (HP:0001799)2.64737074
42Upper limb muscle weakness (HP:0003484)2.59950713
43Dicarboxylic aciduria (HP:0003215)2.56150026
44Abnormality of dicarboxylic acid metabolism (HP:0010995)2.56150026
45Hypoalphalipoproteinemia (HP:0003233)2.54021851
46Loss of speech (HP:0002371)2.52316147
47Generalized aminoaciduria (HP:0002909)2.50327308
48Fat malabsorption (HP:0002630)2.47755459
49Urinary glycosaminoglycan excretion (HP:0003541)2.47494608
50Mucopolysacchariduria (HP:0008155)2.47494608
51Hypoglycemic seizures (HP:0002173)2.45296572
52Hypolipoproteinemia (HP:0010981)2.45193943
53Gout (HP:0001997)2.42496157
54Complement deficiency (HP:0004431)2.42314822
55Beaking of vertebral bodies (HP:0004568)2.40972924
56Atrophic scars (HP:0001075)2.38485734
57Peritonitis (HP:0002586)2.32738080
58Hyperinsulinemic hypoglycemia (HP:0000825)2.30866029
59Progressive neurologic deterioration (HP:0002344)2.29953057
60Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.28718545
61Polyphagia (HP:0002591)2.28104082
62Joint hemorrhage (HP:0005261)2.26073786
63Abnormal hemoglobin (HP:0011902)2.22754859
64Abnormality of polysaccharide metabolism (HP:0011012)2.21912842
65Abnormality of glycosaminoglycan metabolism (HP:0004371)2.21912842
66Abnormality of mucopolysaccharide metabolism (HP:0011020)2.21912842
67Menorrhagia (HP:0000132)2.18476975
68Steatorrhea (HP:0002570)2.18191223
69Malnutrition (HP:0004395)2.17836870
70Abnormality of purine metabolism (HP:0004352)2.17591524
71Joint stiffness (HP:0001387)2.16382518
72Ovoid vertebral bodies (HP:0003300)2.16200285
73Abnormality of complement system (HP:0005339)2.15576549
74Nonimmune hydrops fetalis (HP:0001790)2.14459091
75Vascular tortuosity (HP:0004948)2.14036129
76Hyperbilirubinemia (HP:0002904)2.11567804
77Abnormality of sulfur amino acid metabolism (HP:0004339)2.11388894
78Biconcave vertebral bodies (HP:0004586)2.11357847
79Congenital glaucoma (HP:0001087)2.11295110
80Myocardial infarction (HP:0001658)2.10354698
81Abnormality of proline metabolism (HP:0010907)2.09527554
82Hydroxyprolinuria (HP:0003080)2.09527554
83Mitral stenosis (HP:0001718)2.06438509
84Pancreatitis (HP:0001733)2.05922532
85Protuberant abdomen (HP:0001538)2.05286853
86Abnormality of the Achilles tendon (HP:0005109)2.05274621
87Increased serum ferritin (HP:0003281)2.04469724
88Methylmalonic aciduria (HP:0012120)2.03808954
89Abnormality of aspartate family amino acid metabolism (HP:0010899)2.02564895
90Delayed CNS myelination (HP:0002188)2.01002600
91Opisthotonus (HP:0002179)1.99039027
92Arterial tortuosity (HP:0005116)1.98567606
93Nuclear cataract (HP:0100018)1.97697899
94Metabolic acidosis (HP:0001942)1.97584386
95Spinal rigidity (HP:0003306)1.97557382
96Hepatic necrosis (HP:0002605)1.96743551
97Abnormality of transition element cation homeostasis (HP:0011030)1.96035630
98Petechiae (HP:0000967)1.95969004
99Lethargy (HP:0001254)1.92216583
100Growth hormone excess (HP:0000845)1.92204382
101Abnormal cartilage morphology (HP:0002763)1.92157153
102Abdominal distention (HP:0003270)1.91585843
103Amyloidosis (HP:0011034)1.90460236
104Follicular hyperkeratosis (HP:0007502)1.90345611
105Cardiovascular calcification (HP:0011915)1.89432706
106Purpura (HP:0000979)1.89402676
107Abnormality of serum amino acid levels (HP:0003112)1.89023952
108Vascular calcification (HP:0004934)1.88216255
109Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.87856383
110Abnormal protein N-linked glycosylation (HP:0012347)1.87856383
111Abnormal protein glycosylation (HP:0012346)1.87856383
112Abnormal glycosylation (HP:0012345)1.87856383
113Abnormality of macrophages (HP:0004311)1.87583269
114Abnormality of iron homeostasis (HP:0011031)1.86976275
115Abnormality of glycolysis (HP:0004366)1.86449500
116Blue sclerae (HP:0000592)1.86259573
117Lymphangioma (HP:0100764)1.85983776
118Epiphyseal stippling (HP:0010655)1.85981763
119Abnormality of nucleobase metabolism (HP:0010932)1.85134714
120Insulin resistance (HP:0000855)1.84435139
121Heterochromia iridis (HP:0001100)1.83427826
122Hypokinesia (HP:0002375)1.82584841
123Vomiting (HP:0002013)1.82104346
124Abnormality of methionine metabolism (HP:0010901)1.82091867
125Axonal loss (HP:0003447)1.81393856
126Systemic lupus erythematosus (HP:0002725)1.80485978
127Brushfield spots (HP:0001088)1.80456204
128Hypoventilation (HP:0002791)1.80442127
129Increased serum pyruvate (HP:0003542)1.80297284
130Irritability (HP:0000737)1.79768975
131Wormian bones (HP:0002645)1.78879974
132Achilles tendon contracture (HP:0001771)1.78334051
133Polycythemia (HP:0001901)1.78160274
134Abnormal delivery (HP:0001787)1.77060187
135Symptomatic seizures (HP:0011145)1.76886450
136Hyperglycemia (HP:0003074)1.76321570
137Pulmonary artery stenosis (HP:0004415)1.75964797
138Ectopia lentis (HP:0001083)1.75866257
139Hepatosplenomegaly (HP:0001433)1.75172967
140Type I transferrin isoform profile (HP:0003642)1.74793397
141Aortic dissection (HP:0002647)1.73980536
142Slender build (HP:0001533)1.73841951
143Distal lower limb muscle weakness (HP:0009053)1.73252820
144Asymmetric septal hypertrophy (HP:0001670)1.73207489
145Soft skin (HP:0000977)1.72511580
146Alkalosis (HP:0001948)1.72230423
147Increased muscle lipid content (HP:0009058)1.71187099
148Conjugated hyperbilirubinemia (HP:0002908)1.70962906
149Back pain (HP:0003418)1.70873657
150Generalized amyotrophy (HP:0003700)1.68471523
151Osteopenia (HP:0000938)1.67206452
152Supranuclear gaze palsy (HP:0000605)1.67078796
153Episodic fever (HP:0001954)1.65945289
154Abnormality of urine glucose concentration (HP:0011016)1.65930937
155Glycosuria (HP:0003076)1.65930937
156Abnormal gallbladder morphology (HP:0012437)1.65505315
157Gingival bleeding (HP:0000225)1.65076761
158Microglossia (HP:0000171)1.64948777
159Ankle contracture (HP:0006466)1.63502017
160Cholelithiasis (HP:0001081)1.62142609
161Abnormality of carpal bone ossification (HP:0006257)1.61637089
162Bladder diverticulum (HP:0000015)1.61470635
163Cerebral palsy (HP:0100021)1.59391815
164Muscle fibrillation (HP:0010546)1.56734343
165Craniofacial dystonia (HP:0012179)1.55756155
166Fragile skin (HP:0001030)1.55609754
167Long foot (HP:0001833)1.54653122
168Mildly elevated creatine phosphokinase (HP:0008180)1.54154725

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.50195293
2BCKDK4.59952673
3TAOK23.90521156
4TRIB33.73639845
5TAOK33.03018138
6NME22.95150476
7MAPK152.67147631
8FGFR42.24121684
9EPHB12.13398295
10SIK12.08392279
11KDR2.04465730
12PKN22.02699246
13PIM21.97587329
14VRK21.97226294
15FLT31.91920361
16EPHA31.88172914
17MAP4K21.82002449
18LMTK21.78909470
19TBK11.72018502
20BLK1.70320111
21MAP2K21.69992206
22TESK21.67068604
23NLK1.65414062
24ZAP701.58600488
25SIK31.57248153
26MAP4K11.52874068
27WNK41.44175344
28IRAK31.40731917
29PIK3CG1.31864107
30MAP3K111.28631288
31TGFBR21.25408721
32INSRR1.22233424
33CSK1.19594754
34BCR1.17570345
35LRRK21.14298214
36NEK91.13685881
37TYK21.10435182
38MAP2K71.06069610
39PRKD21.02595465
40DAPK31.01555062
41MAP3K120.99143687
42TAOK10.98150768
43IRAK10.97871560
44CSNK1A1L0.97415960
45FER0.96353074
46MKNK20.95931816
47PTK60.94297814
48DYRK1B0.94187283
49SCYL20.90743651
50JAK30.90628986
51MAP3K10.90405104
52CSNK1G20.88223978
53ABL20.87063015
54CDK190.85878845
55PTK20.85525452
56MAPKAPK30.85327496
57MYLK0.85121454
58DAPK10.83930800
59MARK10.81342728
60IKBKE0.80741433
61TRIM280.78903973
62EPHB20.78444645
63HIPK20.77470157
64MET0.75604022
65JAK10.75570838
66EIF2AK10.75517583
67STK160.74831716
68PRKG20.74674149
69ICK0.74509902
70MST40.74362664
71CSNK1G10.73795242
72MAP3K70.73547061
73BTK0.71873685
74DYRK20.71858252
75EPHA20.67548754
76PAK40.67479461
77MAP3K30.65063846
78MAP2K30.64739306
79RPS6KA40.64104786
80ROCK20.63660415
81SIK20.63477026
82ILK0.63438614
83STK380.62059968
84BMX0.60551319
85PAK60.60499198
86RIPK10.59887145
87GRK50.59809700
88PTK2B0.57704884
89TESK10.57149151
90MAPK40.55686781
91KIT0.54734478
92TTN0.54699996
93ADRBK10.54336046
94DYRK30.53137136
95GRK60.52516722
96PRKD10.52167785
97PDGFRA0.51207476
98MAPK110.49741638
99JAK20.49106557
100PAK30.47345843
101CDK60.46823622
102CDK140.46465217
103ROCK10.46399991
104NME10.46184600
105PAK20.45026449
106GSK3A0.44898637
107RET0.43529925
108PIK3CA0.43377029
109PAK10.43212413
110STK390.42846699
111MAPK120.42709213
112DYRK1A0.41224154
113MAPKAPK20.40726462
114ARAF0.40662924
115MAP2K10.40612700
116ITK0.40005584
117PRKCI0.39670681
118GRK70.39089392
119MAP3K80.38985492
120PINK10.38423634
121CDK40.37997755
122TEC0.37588341
123NTRK10.37182438
124CSNK1G30.36726244
125IKBKB0.35187982
126CAMK2G0.34994461
127MARK20.34489555
128LIMK10.34428757
129MST1R0.34036977
130CDK180.32910776
131SRPK10.30935317
132PRKCZ0.30906478
133SRC0.30662336
134EEF2K0.30254189
135IRAK20.29609905
136RPS6KA20.29219416
137CDK150.29029420
138CDK11A0.28946001
139STK100.28062075
140CDK90.27712805
141MAP3K60.26176858
142MAPKAPK50.26045160
143MAP3K50.25132338
144DDR20.24180198

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.12502485
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.84902399
3Folate biosynthesis_Homo sapiens_hsa007902.68165233
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.63972041
5Sulfur relay system_Homo sapiens_hsa041222.57125978
6Fatty acid degradation_Homo sapiens_hsa000712.54463047
7Protein export_Homo sapiens_hsa030602.47908219
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.38255279
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.36579461
10Tryptophan metabolism_Homo sapiens_hsa003802.33057714
11Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.22409172
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.20099975
13Sulfur metabolism_Homo sapiens_hsa009202.09853251
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.05999566
15SNARE interactions in vesicular transport_Homo sapiens_hsa041301.99235798
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.90494788
17Nitrogen metabolism_Homo sapiens_hsa009101.84756375
18Peroxisome_Homo sapiens_hsa041461.83020419
19Collecting duct acid secretion_Homo sapiens_hsa049661.82763675
20Complement and coagulation cascades_Homo sapiens_hsa046101.81429571
21Propanoate metabolism_Homo sapiens_hsa006401.79692588
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.78757229
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.74029081
24Histidine metabolism_Homo sapiens_hsa003401.73838949
25Arginine biosynthesis_Homo sapiens_hsa002201.70547281
26Butanoate metabolism_Homo sapiens_hsa006501.69382921
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.66544928
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.60826264
29Fat digestion and absorption_Homo sapiens_hsa049751.56642789
30Chemical carcinogenesis_Homo sapiens_hsa052041.56424508
31Other glycan degradation_Homo sapiens_hsa005111.55677260
32Synaptic vesicle cycle_Homo sapiens_hsa047211.54341960
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.53461800
34Fatty acid metabolism_Homo sapiens_hsa012121.49708567
35Proteasome_Homo sapiens_hsa030501.48031930
36beta-Alanine metabolism_Homo sapiens_hsa004101.47435863
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.47390509
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46338226
39Fatty acid elongation_Homo sapiens_hsa000621.41444991
40Pyruvate metabolism_Homo sapiens_hsa006201.38362490
41Arginine and proline metabolism_Homo sapiens_hsa003301.36602627
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33647600
43PPAR signaling pathway_Homo sapiens_hsa033201.31164784
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30743311
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.30530649
46Selenocompound metabolism_Homo sapiens_hsa004501.26602320
47Caffeine metabolism_Homo sapiens_hsa002321.25243096
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.22291143
49Drug metabolism - other enzymes_Homo sapiens_hsa009831.22034898
50Carbon metabolism_Homo sapiens_hsa012001.21735809
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.17696855
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.12353582
53Starch and sucrose metabolism_Homo sapiens_hsa005001.09816053
54Steroid biosynthesis_Homo sapiens_hsa001001.08956236
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07671582
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.06910902
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.06411493
58Tyrosine metabolism_Homo sapiens_hsa003501.06373789
59Glutathione metabolism_Homo sapiens_hsa004801.05850093
60Lysosome_Homo sapiens_hsa041421.05639295
61Pentose phosphate pathway_Homo sapiens_hsa000301.04639553
62Glycosaminoglycan degradation_Homo sapiens_hsa005311.04230679
63Phagosome_Homo sapiens_hsa041451.04193272
64Retinol metabolism_Homo sapiens_hsa008301.03092101
65Cysteine and methionine metabolism_Homo sapiens_hsa002701.02698295
66Biosynthesis of amino acids_Homo sapiens_hsa012301.01935579
67Staphylococcus aureus infection_Homo sapiens_hsa051500.97635027
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97079459
69Bile secretion_Homo sapiens_hsa049760.96073288
70Phenylalanine metabolism_Homo sapiens_hsa003600.95178876
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90318320
72Protein digestion and absorption_Homo sapiens_hsa049740.89450597
73Ribosome_Homo sapiens_hsa030100.87084876
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84584663
75Galactose metabolism_Homo sapiens_hsa000520.83905915
76Vitamin digestion and absorption_Homo sapiens_hsa049770.81459813
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80852390
78Endocytosis_Homo sapiens_hsa041440.80186360
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79656026
80ABC transporters_Homo sapiens_hsa020100.76805978
81Salmonella infection_Homo sapiens_hsa051320.74891623
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72883732
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71130555
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69647573
85Glycerolipid metabolism_Homo sapiens_hsa005610.67402679
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67210231
87Cocaine addiction_Homo sapiens_hsa050300.66244965
88Metabolic pathways_Homo sapiens_hsa011000.59944896
89Bladder cancer_Homo sapiens_hsa052190.58798508
90N-Glycan biosynthesis_Homo sapiens_hsa005100.58585984
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55553981
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.51497910
93Huntingtons disease_Homo sapiens_hsa050160.48823947
94Amoebiasis_Homo sapiens_hsa051460.48528700
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.48396098
96Lysine degradation_Homo sapiens_hsa003100.47535006
97Malaria_Homo sapiens_hsa051440.45593571
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45292202
99Fructose and mannose metabolism_Homo sapiens_hsa000510.45198191
100Oxidative phosphorylation_Homo sapiens_hsa001900.44432119
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.43246298
102Sphingolipid metabolism_Homo sapiens_hsa006000.42777987
103Pertussis_Homo sapiens_hsa051330.42360963
104Pancreatic secretion_Homo sapiens_hsa049720.42013740
105AMPK signaling pathway_Homo sapiens_hsa041520.41956169
106Notch signaling pathway_Homo sapiens_hsa043300.41351101
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40997565
108Focal adhesion_Homo sapiens_hsa045100.40360377
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38570332
110Mineral absorption_Homo sapiens_hsa049780.36888209
111Prion diseases_Homo sapiens_hsa050200.36291924
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31828871
113Parkinsons disease_Homo sapiens_hsa050120.30415506
114ECM-receptor interaction_Homo sapiens_hsa045120.29871769
115Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.29049172
116Insulin resistance_Homo sapiens_hsa049310.28997483
117Linoleic acid metabolism_Homo sapiens_hsa005910.28122459
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27552578
119One carbon pool by folate_Homo sapiens_hsa006700.23054191
120Acute myeloid leukemia_Homo sapiens_hsa052210.21784777
121Vibrio cholerae infection_Homo sapiens_hsa051100.20929108
122Regulation of autophagy_Homo sapiens_hsa041400.19382397
123Renin-angiotensin system_Homo sapiens_hsa046140.18735288
124Shigellosis_Homo sapiens_hsa051310.17385252
125Alzheimers disease_Homo sapiens_hsa050100.15132546
126Arachidonic acid metabolism_Homo sapiens_hsa005900.13356751

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