YIPF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)6.71352905
2behavioral response to nicotine (GO:0035095)6.46984507
3Golgi transport vesicle coating (GO:0048200)5.91875470
4COPI coating of Golgi vesicle (GO:0048205)5.91875470
5maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.99298234
6membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.89435511
7protein retention in ER lumen (GO:0006621)4.67917994
8protein maturation by protein folding (GO:0022417)4.40651747
9regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.23020564
10COPII vesicle coating (GO:0048208)4.16396221
11magnesium ion transport (GO:0015693)4.09792192
12ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.02923883
13gamma-aminobutyric acid transport (GO:0015812)3.94850835
14fucose catabolic process (GO:0019317)3.87709178
15L-fucose metabolic process (GO:0042354)3.87709178
16L-fucose catabolic process (GO:0042355)3.87709178
17UDP-N-acetylglucosamine metabolic process (GO:0006047)3.85957960
18peptide hormone processing (GO:0016486)3.80762782
19serotonin metabolic process (GO:0042428)3.77105143
20regulation of type B pancreatic cell apoptotic process (GO:2000674)3.71326505
21primary amino compound metabolic process (GO:1901160)3.69610214
22sulfation (GO:0051923)3.57905931
23neuronal action potential (GO:0019228)3.45549417
24endocrine pancreas development (GO:0031018)3.44648122
25nucleotide transmembrane transport (GO:1901679)3.44259199
26cellular response to ATP (GO:0071318)3.43920484
27ER overload response (GO:0006983)3.43824844
28negative regulation of glycoprotein biosynthetic process (GO:0010561)3.41643912
29negative regulation of execution phase of apoptosis (GO:1900118)3.40859911
30central nervous system myelination (GO:0022010)3.31207763
31axon ensheathment in central nervous system (GO:0032291)3.31207763
32sphingosine metabolic process (GO:0006670)3.26292264
33regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.26186636
34membrane depolarization during action potential (GO:0086010)3.25226538
35indolalkylamine metabolic process (GO:0006586)3.24383886
36kynurenine metabolic process (GO:0070189)3.23352742
37sequestering of metal ion (GO:0051238)3.21779329
38somite development (GO:0061053)3.19056750
39indolalkylamine catabolic process (GO:0046218)3.12254827
40tryptophan catabolic process (GO:0006569)3.12254827
41indole-containing compound catabolic process (GO:0042436)3.12254827
42retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.12130739
43epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.10977189
44negative regulation of synaptic transmission, GABAergic (GO:0032229)3.08785518
45pyrimidine-containing compound transmembrane transport (GO:0072531)3.07335292
46indole-containing compound metabolic process (GO:0042430)3.06297092
47glandular epithelial cell differentiation (GO:0002067)3.05879546
48positive regulation of fatty acid oxidation (GO:0046321)3.05069531
49negative regulation of cytosolic calcium ion concentration (GO:0051481)3.00962145
50startle response (GO:0001964)2.99223337
51negative regulation of systemic arterial blood pressure (GO:0003085)2.98173392
52ER to Golgi vesicle-mediated transport (GO:0006888)2.97203546
53intracellular pH reduction (GO:0051452)2.96615625
54membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.94529445
55positive regulation of potassium ion transmembrane transport (GO:1901381)2.93530720
56erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.90082325
57L-phenylalanine catabolic process (GO:0006559)2.90082325
58copper ion homeostasis (GO:0055070)2.89095570
59cell proliferation in forebrain (GO:0021846)2.88181304
60GDP-mannose metabolic process (GO:0019673)2.87717007
61action potential (GO:0001508)2.86471174
62response to redox state (GO:0051775)2.86272860
63detection of light stimulus involved in visual perception (GO:0050908)2.85282859
64detection of light stimulus involved in sensory perception (GO:0050962)2.85282859
65positive regulation of mitochondrial fission (GO:0090141)2.85017648
66pH reduction (GO:0045851)2.84684237
67nucleotide-sugar biosynthetic process (GO:0009226)2.82755200
68cell redox homeostasis (GO:0045454)2.80361355
69diol metabolic process (GO:0034311)2.80109208
70membrane repolarization during action potential (GO:0086011)2.78742916
71water-soluble vitamin biosynthetic process (GO:0042364)2.77802469
72negative regulation of glycoprotein metabolic process (GO:1903019)2.77408499
73negative regulation of reactive oxygen species metabolic process (GO:2000378)2.77337317
74nephron epithelium morphogenesis (GO:0072088)2.77044461
75nephron tubule morphogenesis (GO:0072078)2.77044461
76positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.76592360
77cysteine metabolic process (GO:0006534)2.76350256
78synaptic transmission, cholinergic (GO:0007271)2.75164011
79adhesion of symbiont to host cell (GO:0044650)2.74630197
80virion attachment to host cell (GO:0019062)2.74630197
81neuronal action potential propagation (GO:0019227)2.73518329
82membrane budding (GO:0006900)2.72741485
83regulation of action potential (GO:0098900)2.72379253
84tryptophan metabolic process (GO:0006568)2.71938240
85positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.71850033
86toxin metabolic process (GO:0009404)2.71768840
87type B pancreatic cell development (GO:0003323)2.71381990
88transmission of nerve impulse (GO:0019226)2.71339346
89positive regulation of fatty acid beta-oxidation (GO:0032000)2.70832651
90spinal cord motor neuron differentiation (GO:0021522)2.69893053
91mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.68636802
92regulation of hippo signaling (GO:0035330)2.68444107
93cAMP catabolic process (GO:0006198)2.68079250
94postsynaptic membrane organization (GO:0001941)2.67431030
95localization within membrane (GO:0051668)2.66877410
96regulation of metalloenzyme activity (GO:0048552)2.66721302
97regulation of energy homeostasis (GO:2000505)2.66290070
98glycosylceramide metabolic process (GO:0006677)2.66192320
99regulation of membrane repolarization (GO:0060306)2.65447898
100cellular copper ion homeostasis (GO:0006878)2.64995535
101DNA deamination (GO:0045006)2.64895112
102nucleotide transport (GO:0006862)2.64268830
103regulation of glucocorticoid metabolic process (GO:0031943)2.63190108
104erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.61324747
105L-phenylalanine metabolic process (GO:0006558)2.61324747
106cellular ketone body metabolic process (GO:0046950)2.61081696
107regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.61027585
108positive regulation of autophagy (GO:0010508)2.60935050
109mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.60781317
110positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.60781317
111protein N-linked glycosylation via asparagine (GO:0018279)2.60583219
112autophagic vacuole fusion (GO:0000046)2.60363890
113gamma-aminobutyric acid signaling pathway (GO:0007214)2.59817901
114sphingoid metabolic process (GO:0046519)2.58786363
115positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.57573872
116regulation of mesoderm development (GO:2000380)2.57252914
117positive regulation of insulin secretion (GO:0032024)2.57163720
118eye photoreceptor cell differentiation (GO:0001754)2.56130135
119photoreceptor cell differentiation (GO:0046530)2.56130135
120nucleotide-sugar metabolic process (GO:0009225)2.55855601
121response to pheromone (GO:0019236)2.55593785
122peptidyl-asparagine modification (GO:0018196)2.53706493
123purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.53517315
1243-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.53517315
125deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.52644018
126peristalsis (GO:0030432)2.52570499
127autophagic vacuole assembly (GO:0000045)2.52428629
128response to misfolded protein (GO:0051788)2.51966604
129regulation of sequestering of triglyceride (GO:0010889)2.51531124
130peptide metabolic process (GO:0006518)2.51438783
131neurotransmitter metabolic process (GO:0042133)2.51424086
132nucleoside diphosphate catabolic process (GO:0009134)2.50640936
133regulation of neurotransmitter uptake (GO:0051580)2.49756084
134positive regulation of sodium ion transmembrane transport (GO:1902307)2.49188424
135vesicle fusion (GO:0006906)2.47924732
136parturition (GO:0007567)2.45945948
137protein polyglutamylation (GO:0018095)2.45896770
138negative regulation of mast cell activation (GO:0033004)2.45599151
139neuromuscular synaptic transmission (GO:0007274)2.45405629
140protein localization to synapse (GO:0035418)2.44521637
141negative regulation of astrocyte differentiation (GO:0048712)2.44076785
142epithelial cilium movement (GO:0003351)2.43837785
143protein N-linked glycosylation (GO:0006487)2.43711968
144fatty acid elongation (GO:0030497)2.43709083
145positive regulation of action potential (GO:0045760)2.43439679
146glycolipid catabolic process (GO:0019377)2.43376617
147cornea development in camera-type eye (GO:0061303)2.42904539
148dopamine transport (GO:0015872)2.42836461
149reflex (GO:0060004)2.42445968
150regulation of protein glycosylation (GO:0060049)2.42268825
151interkinetic nuclear migration (GO:0022027)2.42095497
152cyclic nucleotide catabolic process (GO:0009214)2.41680854
153regulation of potassium ion transmembrane transport (GO:1901379)2.41100687
154cerebellar Purkinje cell differentiation (GO:0021702)2.40630693
155positive regulation of cardiac muscle cell differentiation (GO:2000727)2.40079056
156urinary tract smooth muscle contraction (GO:0014848)2.38913290
157regulation of integrin-mediated signaling pathway (GO:2001044)2.38530784
158glycosphingolipid catabolic process (GO:0046479)2.38112568
159kidney morphogenesis (GO:0060993)2.37733263
160synaptic transmission, glutamatergic (GO:0035249)2.37439895
161dopamine biosynthetic process (GO:0042416)2.37428801
162response to hydroperoxide (GO:0033194)2.36137943
163behavioral fear response (GO:0001662)2.35813977
164behavioral defense response (GO:0002209)2.35813977
165neural tube formation (GO:0001841)2.35545833
166negative regulation of telomere maintenance (GO:0032205)2.35410243
167pyrimidine nucleobase catabolic process (GO:0006208)2.35389081
168response to dietary excess (GO:0002021)2.35081780
169protein import into peroxisome matrix (GO:0016558)2.34868487
170protein localization to cilium (GO:0061512)2.34766365
171tissue regeneration (GO:0042246)2.34520935
172protoporphyrinogen IX metabolic process (GO:0046501)2.34228243
173fear response (GO:0042596)2.33632778
174dendritic spine morphogenesis (GO:0060997)2.31822201
175positive regulation of oligodendrocyte differentiation (GO:0048714)2.30796188
176cardiovascular system development (GO:0072358)2.30623743
177endoderm formation (GO:0001706)2.30539852
178vesicle coating (GO:0006901)2.30529548
179detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.30520949
180glutamate receptor signaling pathway (GO:0007215)2.30035727
181GPI anchor biosynthetic process (GO:0006506)2.29830110
182long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.29125482
183G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.29067564
184activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.28964625
185creatine metabolic process (GO:0006600)2.27746605
186negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.27291701
187exocrine pancreas development (GO:0031017)2.27251095
188organelle membrane fusion (GO:0090174)2.26876434
189Golgi organization (GO:0007030)2.26357977
190protein localization to endosome (GO:0036010)2.25626277
191mitochondrial calcium ion transport (GO:0006851)2.24865218
192cellular response to leptin stimulus (GO:0044320)2.24402217
193autophagy (GO:0006914)2.22839014
194positive regulation of transforming growth factor beta production (GO:0071636)2.19212379
195regulation of transforming growth factor beta2 production (GO:0032909)2.18802668

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.34284451
2EZH2_22144423_ChIP-Seq_EOC_Human4.72409406
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.85745600
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.44837008
5GBX2_23144817_ChIP-Seq_PC3_Human3.20284041
6ZNF274_21170338_ChIP-Seq_K562_Hela2.86868471
7* GABP_17652178_ChIP-ChIP_JURKAT_Human2.82252363
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.41495340
9PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.38657147
10STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.30892394
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.20164999
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.13787395
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.08470587
14CLOCK_20551151_ChIP-Seq_293T_Human2.08229295
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07572591
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05927880
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.05278950
18VDR_22108803_ChIP-Seq_LS180_Human2.02612227
19* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.01630748
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.00912470
21IGF1R_20145208_ChIP-Seq_DFB_Human1.98201148
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.96769743
23SOX2_20726797_ChIP-Seq_SW620_Human1.96531375
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.96509378
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.93957509
26REST_21632747_ChIP-Seq_MESCs_Mouse1.93665105
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.93476266
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.92578354
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92332297
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91504940
31NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.89999553
32NRF2_20460467_ChIP-Seq_MEFs_Mouse1.89999553
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.87771538
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83037733
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.80370206
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.78534141
37KAP1_22055183_ChIP-Seq_ESCs_Mouse1.77400929
38CREB1_15753290_ChIP-ChIP_HEK293T_Human1.75967363
39RXR_22158963_ChIP-Seq_LIVER_Mouse1.73196881
40SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.72106706
41PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.66104168
42* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.64907818
43DROSHA_22980978_ChIP-Seq_HELA_Human1.64807660
44IRF1_19129219_ChIP-ChIP_H3396_Human1.63874043
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.62803246
46P300_19829295_ChIP-Seq_ESCs_Human1.62030322
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60069122
48SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.58940112
49CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.58219118
50FUS_26573619_Chip-Seq_HEK293_Human1.57866905
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.57192860
52ER_23166858_ChIP-Seq_MCF-7_Human1.57008146
53BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.55043844
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.52620921
55ELK1_22589737_ChIP-Seq_MCF10A_Human1.52495204
56SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.51567163
57EZH2_18974828_ChIP-Seq_MESCs_Mouse1.51330602
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.51330602
59EWS_26573619_Chip-Seq_HEK293_Human1.50472472
60STAT3_23295773_ChIP-Seq_U87_Human1.49725205
61SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.48696740
62WT1_19549856_ChIP-ChIP_CCG9911_Human1.48219668
63SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.46635538
64EGR1_23403033_ChIP-Seq_LIVER_Mouse1.46361345
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45247783
66RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.43865684
67RNF2_27304074_Chip-Seq_NSC_Mouse1.42882516
68Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.42652184
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40793421
70AR_21572438_ChIP-Seq_LNCaP_Human1.39028923
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37367103
72LXR_22158963_ChIP-Seq_LIVER_Mouse1.37183328
73TCF4_23295773_ChIP-Seq_U87_Human1.36826351
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.36409623
75FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36195063
76SMAD4_21799915_ChIP-Seq_A2780_Human1.35974842
77MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34788781
78ELK1_19687146_ChIP-ChIP_HELA_Human1.34625577
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34233226
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31265081
81AR_25329375_ChIP-Seq_VCAP_Human1.30790452
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29835606
83* FOXA1_25552417_ChIP-Seq_VCAP_Human1.29686209
84REST_18959480_ChIP-ChIP_MESCs_Mouse1.29637509
85SALL4_18804426_ChIP-ChIP_XEN_Mouse1.29213302
86* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.28968389
87* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27976104
88TP53_16413492_ChIP-PET_HCT116_Human1.27623567
89PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.26454665
90* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.26157540
91FLI1_27457419_Chip-Seq_LIVER_Mouse1.25864105
92BCAT_22108803_ChIP-Seq_LS180_Human1.25130682
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24240654
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24240654
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23879112
96RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23874327
97SOX2_27498859_Chip-Seq_STOMACH_Mouse1.21789241
98PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.21127190
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20956241
100ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20690194
101HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20613351
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19494127
103REST_19997604_ChIP-ChIP_NEURONS_Mouse1.19333809
104PIAS1_25552417_ChIP-Seq_VCAP_Human1.18230318
105ELF1_17652178_ChIP-ChIP_JURKAT_Human1.17890933
106GATA4_25053715_ChIP-Seq_YYC3_Human1.17237946
107GATA1_22025678_ChIP-Seq_K562_Human1.16169374
108PPARA_22158963_ChIP-Seq_LIVER_Mouse1.16049216
109SMAD3_21741376_ChIP-Seq_EPCs_Human1.15605921
110TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13496705
111PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12849279
112ERG_20517297_ChIP-Seq_VCAP_Human1.12231029
113FLI1_21867929_ChIP-Seq_TH2_Mouse1.11918374
114PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11733633
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10858190
116SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.10769337
117CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10005626
118PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09510365
119NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09256935
120TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09216835
121SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08947079
122* VDR_23849224_ChIP-Seq_CD4+_Human1.08780988
123PRDM14_20953172_ChIP-Seq_ESCs_Human1.07803958
124AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06971437
125RUNX2_22187159_ChIP-Seq_PCA_Human1.06277990
126ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05490078
127NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05376235
128ZNF263_19887448_ChIP-Seq_K562_Human1.04981328
129SOX2_19829295_ChIP-Seq_ESCs_Human1.04746908
130NANOG_19829295_ChIP-Seq_ESCs_Human1.04746908
131RING1B_27294783_Chip-Seq_ESCs_Mouse1.04396312
132GATA3_27048872_Chip-Seq_THYMUS_Human1.03949807
133IRF8_22096565_ChIP-ChIP_GC-B_Human1.03486252
134* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02959879
135SRF_21415370_ChIP-Seq_HL-1_Mouse1.02756465
136IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02236307
137CBP_20019798_ChIP-Seq_JUKART_Human1.02236307
138CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02220716
139SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01704049
140HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01523064
141TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01263862
142* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.01056236
143SOX2_21211035_ChIP-Seq_LN229_Gbm1.00680485
144CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.00674131
145TDRD3_21172665_ChIP-Seq_MCF-7_Human1.00650554
146TCF4_22108803_ChIP-Seq_LS180_Human0.99969859
147GATA3_24758297_ChIP-Seq_MCF-7_Human0.99770720
148CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99251377
149HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99087894
150ARNT_22903824_ChIP-Seq_MCF-7_Human0.98351365
151SMAD4_21741376_ChIP-Seq_EPCs_Human0.98189467
152* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97292433
153* FOXA1_25329375_ChIP-Seq_VCAP_Human0.97292433
154MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97265873
155PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97210157
156CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96685895
157* GATA3_21878914_ChIP-Seq_MCF-7_Human0.96383891
158RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96130910
159NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95279613
160* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.95273968
161MYB_21317192_ChIP-Seq_ERMYB_Mouse0.95086104
162AHR_22903824_ChIP-Seq_MCF-7_Human0.94561876
163TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93506560
164GATA3_26560356_Chip-Seq_TH2_Human0.93489831
165TP53_22573176_ChIP-Seq_HFKS_Human0.93377524
166TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92953263
167EOMES_21245162_ChIP-Seq_HESCs_Human0.92479152
168EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92090602
169* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.91235127
170TAF15_26573619_Chip-Seq_HEK293_Human0.91115203
171* FOXO3_23340844_ChIP-Seq_DLD1_Human0.90803356
172CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90291187
173PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90233885
174* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88248697
175TP63_23658742_ChIP-Seq_EP156T_Human0.87754977
176NANOG_18555785_Chip-Seq_ESCs_Mouse0.85849102
177SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85427320
178* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.84203048
179* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.84119921
180FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.83443754
181TFEB_21752829_ChIP-Seq_HELA_Human0.83201059
182CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.82194192
183AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81610158
184PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.79585370

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis4.21850950
2MP0000013_abnormal_adipose_tissue4.02249150
3MP0002009_preneoplasia3.38471872
4MP0003183_abnormal_peptide_metabolism3.28388559
5MP0002877_abnormal_melanocyte_morpholog3.15764747
6MP0008260_abnormal_autophagy3.09087544
7MP0010386_abnormal_urinary_bladder2.83487522
8MP0000569_abnormal_digit_pigmentation2.81227455
9MP0003646_muscle_fatigue2.74292459
10MP0009046_muscle_twitch2.66440005
11MP0004043_abnormal_pH_regulation2.64697540
12MP0009780_abnormal_chondrocyte_physiolo2.44980857
13MP0009745_abnormal_behavioral_response2.43557345
14MP0005058_abnormal_lysosome_morphology2.33392915
15MP0003656_abnormal_erythrocyte_physiolo2.22805152
16MP0002272_abnormal_nervous_system2.22755946
17MP0005310_abnormal_salivary_gland2.22349667
18MP0003787_abnormal_imprinting2.19694336
19MP0005379_endocrine/exocrine_gland_phen2.19614155
20MP0001968_abnormal_touch/_nociception2.18846699
21MP0002064_seizures2.16924765
22MP0002693_abnormal_pancreas_physiology2.13579185
23MP0005551_abnormal_eye_electrophysiolog2.11550768
24MP0005646_abnormal_pituitary_gland2.10282003
25MP0001944_abnormal_pancreas_morphology2.07908650
26MP0001485_abnormal_pinna_reflex2.02553775
27MP0006292_abnormal_olfactory_placode2.01284982
28MP0003635_abnormal_synaptic_transmissio1.97830373
29MP0001661_extended_life_span1.96054475
30MP0005408_hypopigmentation1.95355149
31MP0005220_abnormal_exocrine_pancreas1.90209782
32MP0006054_spinal_hemorrhage1.88275390
33MP0003329_amyloid_beta_deposits1.85964071
34MP0004133_heterotaxia1.84994553
35MP0003724_increased_susceptibility_to1.83585228
36MP0002909_abnormal_adrenal_gland1.82122590
37MP0001542_abnormal_bone_strength1.81547359
38MP0002102_abnormal_ear_morphology1.81367493
39MP0002160_abnormal_reproductive_system1.79325725
40MP0005636_abnormal_mineral_homeostasis1.78989146
41MP0004142_abnormal_muscle_tone1.78219987
42MP0010234_abnormal_vibrissa_follicle1.77612100
43MP0002735_abnormal_chemical_nociception1.74735076
44MP0002063_abnormal_learning/memory/cond1.73533985
45MP0008877_abnormal_DNA_methylation1.71461655
46MP0002139_abnormal_hepatobiliary_system1.70926178
47MP0000631_abnormal_neuroendocrine_gland1.70178602
48MP0008872_abnormal_physiological_respon1.70097934
49MP0009643_abnormal_urine_homeostasis1.69790632
50MP0005332_abnormal_amino_acid1.68858069
51MP0001486_abnormal_startle_reflex1.67080418
52MP0004147_increased_porphyrin_level1.66421590
53MP0003806_abnormal_nucleotide_metabolis1.65332156
54MP0003880_abnormal_central_pattern1.65269381
55MP0003186_abnormal_redox_activity1.64840067
56MP0001756_abnormal_urination1.64171127
57MP0002572_abnormal_emotion/affect_behav1.62983861
58MP0002876_abnormal_thyroid_physiology1.59686429
59MP0002166_altered_tumor_susceptibility1.58790334
60MP0002733_abnormal_thermal_nociception1.57110702
61MP0001765_abnormal_ion_homeostasis1.57044373
62MP0004185_abnormal_adipocyte_glucose1.56490698
63MP0003879_abnormal_hair_cell1.50217060
64MP0002138_abnormal_hepatobiliary_system1.48013241
65MP0005451_abnormal_body_composition1.47590716
66MP0002067_abnormal_sensory_capabilities1.46901147
67MP0002653_abnormal_ependyma_morphology1.46623560
68MP0000604_amyloidosis1.46562623
69MP0002736_abnormal_nociception_after1.46219071
70MP0000003_abnormal_adipose_tissue1.45498281
71MP0001970_abnormal_pain_threshold1.45272403
72MP0001502_abnormal_circadian_rhythm1.44735346
73MP0000920_abnormal_myelination1.43653635
74MP0005423_abnormal_somatic_nervous1.42615438
75MP0002557_abnormal_social/conspecific_i1.41687231
76MP0001501_abnormal_sleep_pattern1.40984696
77MP0000613_abnormal_salivary_gland1.39530923
78MP0004145_abnormal_muscle_electrophysio1.39479047
79MP0003718_maternal_effect1.38123236
80MP0002078_abnormal_glucose_homeostasis1.37063669
81MP0000049_abnormal_middle_ear1.36449821
82MP0000778_abnormal_nervous_system1.36359324
83MP0008438_abnormal_cutaneous_collagen1.36063836
84MP0005389_reproductive_system_phenotype1.33455906
85MP0000230_abnormal_systemic_arterial1.31249693
86MP0004924_abnormal_behavior1.31064028
87MP0005386_behavior/neurological_phenoty1.31064028
88MP0004859_abnormal_synaptic_plasticity1.30510732
89MP0002234_abnormal_pharynx_morphology1.29379848
90MP0002734_abnormal_mechanical_nocicepti1.29349267
91MP0009384_cardiac_valve_regurgitation1.28976268
92MP0000427_abnormal_hair_cycle1.27747539
93MP0004742_abnormal_vestibular_system1.25420960
94MP0001440_abnormal_grooming_behavior1.23484620
95MP0005084_abnormal_gallbladder_morpholo1.23194628
96MP0001881_abnormal_mammary_gland1.23149824
97MP0005174_abnormal_tail_pigmentation1.23000591
98MP0005645_abnormal_hypothalamus_physiol1.22290170
99MP0000639_abnormal_adrenal_gland1.21293559
100MP0003136_yellow_coat_color1.21170480
101MP0000955_abnormal_spinal_cord1.20235154
102MP0002837_dystrophic_cardiac_calcinosis1.19242477
103MP0004782_abnormal_surfactant_physiolog1.18325849
104MP0006072_abnormal_retinal_apoptosis1.16571660
105MP0005365_abnormal_bile_salt1.16053942
106MP0005253_abnormal_eye_physiology1.15586051
107MP0005275_abnormal_skin_tensile1.15364429
108MP0008875_abnormal_xenobiotic_pharmacok1.14410028
109MP0005535_abnormal_body_temperature1.12320445
110MP0003119_abnormal_digestive_system1.12230653
111MP0003938_abnormal_ear_development1.12130931
112MP0000026_abnormal_inner_ear1.10204802
113MP0006036_abnormal_mitochondrial_physio1.09399667
114MP0003011_delayed_dark_adaptation1.09035273
115MP0002752_abnormal_somatic_nervous1.06688968
116MP0002882_abnormal_neuron_morphology1.06239565
117MP0002971_abnormal_brown_adipose1.05670027
118MP0002928_abnormal_bile_duct1.05425276
119MP0002184_abnormal_innervation1.04898411
120MP0001533_abnormal_skeleton_physiology1.04083565
121MP0005195_abnormal_posterior_eye1.03695268
122MP0001963_abnormal_hearing_physiology1.02715634
123MP0004215_abnormal_myocardial_fiber1.00017858
124MP0005164_abnormal_response_to0.98699319
125MP0005375_adipose_tissue_phenotype0.98464823
126MP0002118_abnormal_lipid_homeostasis0.97755665
127MP0003300_gastrointestinal_ulcer0.97479436
128MP0003633_abnormal_nervous_system0.96299376
129MP0001919_abnormal_reproductive_system0.95987492
130MP0002229_neurodegeneration0.95388058
131MP0000383_abnormal_hair_follicle0.95201937
132MP0003890_abnormal_embryonic-extraembry0.93280541
133MP0003795_abnormal_bone_structure0.93108289
134MP0002006_tumorigenesis0.92462438
135MP0001764_abnormal_homeostasis0.92276458
136MP0009840_abnormal_foam_cell0.92249331
137MP0000538_abnormal_urinary_bladder0.91393151
138MP0003868_abnormal_feces_composition0.90628133
139MP0002277_abnormal_respiratory_mucosa0.90479302
140MP0003283_abnormal_digestive_organ0.89680099
141MP0000681_abnormal_thyroid_gland0.88796720
142MP0002938_white_spotting0.88237487
143MP0003632_abnormal_nervous_system0.86520298
144MP0003631_nervous_system_phenotype0.86442913
145MP0001346_abnormal_lacrimal_gland0.85100476
146MP0003937_abnormal_limbs/digits/tail_de0.84861717
147MP0003137_abnormal_impulse_conducting0.84554004
148MP0002933_joint_inflammation0.84486919
149MP0004885_abnormal_endolymph0.83889179
150MP0001986_abnormal_taste_sensitivity0.83439397
151MP0008775_abnormal_heart_ventricle0.82475406
152MP0001666_abnormal_nutrient_absorption0.82469589
153MP0003959_abnormal_lean_body0.81927903
154MP0001851_eye_inflammation0.81047629
155MP0000609_abnormal_liver_physiology0.80950377
156MP0006082_CNS_inflammation0.79787813
157MP0001664_abnormal_digestion0.79671332
158MP0002638_abnormal_pupillary_reflex0.79278702
159MP0002163_abnormal_gland_morphology0.79082812
160MP0005584_abnormal_enzyme/coenzyme_acti0.78835555
161MP0003221_abnormal_cardiomyocyte_apopto0.77957893
162MP0004270_analgesia0.77697177
163MP0002066_abnormal_motor_capabilities/c0.77633367
164MP0002822_catalepsy0.77341359
165MP0006276_abnormal_autonomic_nervous0.76450627
166MP0005360_urolithiasis0.76239793
167MP0005666_abnormal_adipose_tissue0.74767494
168MP0005448_abnormal_energy_balance0.73772665
169MP0001299_abnormal_eye_distance/0.72625494
170MP0003950_abnormal_plasma_membrane0.72581650
171MP0005377_hearing/vestibular/ear_phenot0.71880704
172MP0005395_other_phenotype0.69619491
173MP0003953_abnormal_hormone_level0.68453612
174MP0009785_altered_susceptibility_to0.66926860
175MP0001905_abnormal_dopamine_level0.66850785
176MP0004130_abnormal_muscle_cell0.63446885
177MP0008469_abnormal_protein_level0.63318072
178MP0004272_abnormal_basement_membrane0.62316961
179MP0002998_abnormal_bone_remodeling0.61799003
180MP0009333_abnormal_splenocyte_physiolog0.61705553
181MP0004264_abnormal_extraembryonic_tissu0.61062460

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)4.45544333
2Pancreatic cysts (HP:0001737)4.35044465
3Hypoglycemic seizures (HP:0002173)4.13923326
4Pancreatic fibrosis (HP:0100732)3.97235248
5Molar tooth sign on MRI (HP:0002419)3.95392888
6Abnormality of midbrain morphology (HP:0002418)3.95392888
7Genetic anticipation (HP:0003743)3.89976123
8Hyperventilation (HP:0002883)3.78137041
9True hermaphroditism (HP:0010459)3.76320372
10Nephronophthisis (HP:0000090)3.64489510
11Congenital stationary night blindness (HP:0007642)3.62666265
12Progressive cerebellar ataxia (HP:0002073)3.62578272
13Hyperinsulinemic hypoglycemia (HP:0000825)3.61572694
14Abnormality of aromatic amino acid family metabolism (HP:0004338)3.56364826
15Symptomatic seizures (HP:0011145)3.44356293
16Progressive neurologic deterioration (HP:0002344)3.19437021
17Type II lissencephaly (HP:0007260)3.15860884
18Abnormal drinking behavior (HP:0030082)3.11278061
19Polydipsia (HP:0001959)3.11278061
20Clumsiness (HP:0002312)3.11007322
21Abnormality of the renal medulla (HP:0100957)3.08254429
22Hypothermia (HP:0002045)3.07358898
23Protruding tongue (HP:0010808)3.00676858
24Generalized aminoaciduria (HP:0002909)2.94776512
25Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.91839763
26Insulin-resistant diabetes mellitus (HP:0000831)2.89606277
27Febrile seizures (HP:0002373)2.89541619
28Gaze-evoked nystagmus (HP:0000640)2.87493720
29Gout (HP:0001997)2.84427733
30Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.80634992
31Cystic liver disease (HP:0006706)2.74882250
32Hyperglycemia (HP:0003074)2.72936857
33Dysautonomia (HP:0002459)2.70809293
34Ketoacidosis (HP:0001993)2.70398781
35Dysostosis multiplex (HP:0000943)2.67294744
36Abnormality of the renal cortex (HP:0011035)2.65821876
37Pheochromocytoma (HP:0002666)2.65520080
38Decreased circulating renin level (HP:0003351)2.64805463
39Chorioretinal atrophy (HP:0000533)2.63828212
40Broad-based gait (HP:0002136)2.63693847
41Vacuolated lymphocytes (HP:0001922)2.63575404
42Inability to walk (HP:0002540)2.62880922
43Focal seizures (HP:0007359)2.62205424
44Absent/shortened dynein arms (HP:0200106)2.58555338
45Dynein arm defect of respiratory motile cilia (HP:0012255)2.58555338
46Focal motor seizures (HP:0011153)2.58019399
47Abolished electroretinogram (ERG) (HP:0000550)2.56025026
48Neuroendocrine neoplasm (HP:0100634)2.55726974
49Pendular nystagmus (HP:0012043)2.55580696
50Thoracolumbar scoliosis (HP:0002944)2.52039312
51Abnormal protein glycosylation (HP:0012346)2.51661316
52Abnormal glycosylation (HP:0012345)2.51661316
53Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.51661316
54Abnormal protein N-linked glycosylation (HP:0012347)2.51661316
55Large for gestational age (HP:0001520)2.51394745
56Medial flaring of the eyebrow (HP:0010747)2.48327675
57Aplasia/Hypoplasia of the tibia (HP:0005772)2.47386718
58Chronic hepatic failure (HP:0100626)2.44149190
59Abnormality of the intrinsic pathway (HP:0010989)2.42873419
60Abnormality of calcium-phosphate metabolism (HP:0100530)2.42155622
61Abnormality of liposaccharide metabolism (HP:0010968)2.41111337
62Abnormality of glycosphingolipid metabolism (HP:0004343)2.41111337
63Abnormality of glycolipid metabolism (HP:0010969)2.41111337
64Patellar aplasia (HP:0006443)2.39878224
65Aplasia/Hypoplasia of the patella (HP:0006498)2.39363842
66Sclerocornea (HP:0000647)2.39126918
67Neurofibrillary tangles (HP:0002185)2.37876881
68Tubular atrophy (HP:0000092)2.37849178
69Furrowed tongue (HP:0000221)2.35662149
70Cerebral hemorrhage (HP:0001342)2.33429018
71Hypokalemic alkalosis (HP:0001949)2.32248841
72Concave nail (HP:0001598)2.28521611
73Limb dystonia (HP:0002451)2.25239120
74Male pseudohermaphroditism (HP:0000037)2.24444508
75Spastic paraparesis (HP:0002313)2.23757065
76Polyuria (HP:0000103)2.22318220
77Attenuation of retinal blood vessels (HP:0007843)2.22176503
78Increased neuronal autofluorescent lipopigment (HP:0002074)2.20565991
79Dialeptic seizures (HP:0011146)2.18722664
80Atonic seizures (HP:0010819)2.18171838
81Keratoconus (HP:0000563)2.17434465
82Increased corneal curvature (HP:0100692)2.17434465
83Tachypnea (HP:0002789)2.12902083
84Birth length less than 3rd percentile (HP:0003561)2.11852254
85Ketosis (HP:0001946)2.11247049
86Segmental peripheral demyelination/remyelination (HP:0003481)2.08917584
87Agitation (HP:0000713)2.07453849
88Stomach cancer (HP:0012126)2.06541931
89Brushfield spots (HP:0001088)2.06004876
90Severe muscular hypotonia (HP:0006829)2.05833913
91Progressive inability to walk (HP:0002505)2.05736673
92Congenital, generalized hypertrichosis (HP:0004540)2.05734016
93Type I transferrin isoform profile (HP:0003642)2.05569325
94Gait imbalance (HP:0002141)2.05005341
95Hypomagnesemia (HP:0002917)2.04969476
96Abnormal respiratory epithelium morphology (HP:0012253)2.04920966
97Abnormal respiratory motile cilium morphology (HP:0005938)2.04920966
98Chronic bronchitis (HP:0004469)2.03309632
99Hepatic necrosis (HP:0002605)2.03032599
100Abnormality of the common coagulation pathway (HP:0010990)2.01295056
101Reduced antithrombin III activity (HP:0001976)2.00943713
102Abnormality of alanine metabolism (HP:0010916)2.00591557
103Hyperalaninemia (HP:0003348)2.00591557
104Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.00591557
105Irregular vertebral endplates (HP:0003301)2.00557997
106Epileptic encephalopathy (HP:0200134)2.00206074
107Acute encephalopathy (HP:0006846)1.99868235
108Hemiparesis (HP:0001269)1.99609694
109Congenital sensorineural hearing impairment (HP:0008527)1.99074822
110Anencephaly (HP:0002323)1.98604124
111Absence seizures (HP:0002121)1.98057583
112Congenital hepatic fibrosis (HP:0002612)1.97653442
113Decreased central vision (HP:0007663)1.97031418
114Decreased electroretinogram (ERG) amplitude (HP:0000654)1.96650752
115Visual hallucinations (HP:0002367)1.95673106
116Abnormality of the pancreatic islet cells (HP:0006476)1.95480888
117Abnormality of endocrine pancreas physiology (HP:0012093)1.95480888
118Acute necrotizing encephalopathy (HP:0006965)1.95275709
119Increased cerebral lipofuscin (HP:0011813)1.94905187
120Irritability (HP:0000737)1.94620544
121Lissencephaly (HP:0001339)1.94558076
122Aplasia/Hypoplasia of the tongue (HP:0010295)1.93513825
123Abnormal mitochondria in muscle tissue (HP:0008316)1.93426714
124Hyperactive renin-angiotensin system (HP:0000841)1.93388321
125Retinal atrophy (HP:0001105)1.92905524
126Mucopolysacchariduria (HP:0008155)1.92853473
127Urinary glycosaminoglycan excretion (HP:0003541)1.92853473
128Cerebellar dysplasia (HP:0007033)1.92582280
129Absent rod-and cone-mediated responses on ERG (HP:0007688)1.92163683
130Abnormality of magnesium homeostasis (HP:0004921)1.91665581
131Microretrognathia (HP:0000308)1.90554065
132Glycosuria (HP:0003076)1.90490913
133Abnormality of urine glucose concentration (HP:0011016)1.90490913
134Glucose intolerance (HP:0000833)1.89977198
135Abnormality of binocular vision (HP:0011514)1.89346308
136Diplopia (HP:0000651)1.89346308
137Hyperparathyroidism (HP:0000843)1.88897774
138Abnormality of the pons (HP:0007361)1.87659834
139Sensorimotor neuropathy (HP:0007141)1.86231190
140Fair hair (HP:0002286)1.85998205
141Abnormal rod and cone electroretinograms (HP:0008323)1.85899614
142Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.85863577
143Degeneration of the lateral corticospinal tracts (HP:0002314)1.85863577
144Short hallux (HP:0010109)1.84910193
145Paraparesis (HP:0002385)1.84494663
146Pancreatic islet-cell hyperplasia (HP:0004510)1.83053633
147Congenital primary aphakia (HP:0007707)1.83015080
148Abnormality of polysaccharide metabolism (HP:0011012)1.81869384
149Abnormality of glycosaminoglycan metabolism (HP:0004371)1.81869384
150Abnormality of mucopolysaccharide metabolism (HP:0011020)1.81869384
151Hemiplegia (HP:0002301)1.81830559
152Hypoplasia of the pons (HP:0012110)1.81519512
153Flat capital femoral epiphysis (HP:0003370)1.81313484
154Retinal dysplasia (HP:0007973)1.81229025
155CNS hypomyelination (HP:0003429)1.80900927
156Epiphyseal stippling (HP:0010655)1.80767033
157Irregular epiphyses (HP:0010582)1.79980953
158Abnormal ciliary motility (HP:0012262)1.79913591
159Abnormal autonomic nervous system physiology (HP:0012332)1.79910697
160Bulbous nose (HP:0000414)1.79754281
161Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.79667146
162Drooling (HP:0002307)1.79286081
163Hyperglycinemia (HP:0002154)1.79142091
164Abnormal urine output (HP:0012590)1.77630430
165Small epiphyses (HP:0010585)1.76669351
166Insulin resistance (HP:0000855)1.76334429
167Ulnar claw (HP:0001178)1.76225655
168Aplasia/Hypoplasia of the hallux (HP:0008362)1.76102911
169Bony spicule pigmentary retinopathy (HP:0007737)1.75989438
170Abnormality of the vertebral endplates (HP:0005106)1.75661598
171Protuberant abdomen (HP:0001538)1.75472126
172Symphalangism affecting the phalanges of the hand (HP:0009773)1.74851862
173Status epilepticus (HP:0002133)1.74830479
174Abnormality of chloride homeostasis (HP:0011422)1.74419771
175Abnormality of the fovea (HP:0000493)1.73693233
176Exocrine pancreatic insufficiency (HP:0001738)1.73690161
177Abnormality of purine metabolism (HP:0004352)1.73218390
178Arterial tortuosity (HP:0005116)1.72802558
179Abnormality of renin-angiotensin system (HP:0000847)1.72686699
180Generalized tonic-clonic seizures (HP:0002069)1.72639554
181Disproportionate short-trunk short stature (HP:0003521)1.72488793
182Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.72299810
183Xanthomatosis (HP:0000991)1.72267425
184Oligodactyly (hands) (HP:0001180)1.72151734
185Delusions (HP:0000746)1.72084290
186Macroglossia (HP:0000158)1.71603371
187Tetany (HP:0001281)1.71395414
188Small hand (HP:0200055)1.70760791
189Decreased activity of mitochondrial respiratory chain (HP:0008972)1.70548711
190Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.70548711
191Menstrual irregularities (HP:0000858)1.70472712
192Hyperglycinuria (HP:0003108)1.70448169
193Impaired smooth pursuit (HP:0007772)1.70381741
194Vascular tortuosity (HP:0004948)1.70156696
195Restlessness (HP:0000711)1.69768105

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK153.54167710
2ARAF3.36252396
3TLK13.12186385
4ADRBK23.05166767
5MAPKAPK33.01274500
6STK392.77513591
7MST42.49621888
8GRK12.30488683
9WNK42.28867552
10FRK2.28708447
11CASK2.26467381
12NTRK32.15413427
13EIF2AK32.12713864
14OXSR12.12407478
15BCKDK2.05853980
16DAPK22.00300868
17MAP3K131.98937274
18MAPK131.98613591
19INSRR1.92886230
20MARK11.92518142
21MET1.92432158
22KSR21.88335551
23BRSK21.81204364
24TAOK31.79806325
25ZAK1.78999589
26MAP3K41.72137813
27SCYL21.67170598
28NTRK11.60249439
29RAF11.56714698
30STK38L1.55141789
31MAPKAPK51.52945860
32NEK61.51808149
33NTRK21.51792421
34MUSK1.51714425
35ERBB41.47408516
36IRAK31.38912811
37TESK21.38311809
38MAP2K71.37987944
39ADRBK11.34867607
40CAMKK21.34467763
41MOS1.32350009
42BRAF1.31902282
43BCR1.31661884
44NME21.31456720
45ACVR1B1.30169383
46NLK1.27977193
47FLT31.26920192
48EPHA31.26766057
49AKT31.26148533
50PINK11.24853751
51MAP4K21.19169139
52HIPK21.16820679
53PRKCG1.15663758
54MAP3K21.14683728
55SGK21.13473016
56PIK3CG1.13272937
57PHKG21.12424546
58PHKG11.12424546
59LIMK11.12173814
60SGK2231.11176694
61SGK4941.11176694
62MAP2K41.09756955
63ERN11.07925936
64TRPM71.07667862
65PIK3CA1.07560743
66PBK1.03181563
67FER1.02914047
68IRAK11.01042742
69MAP3K120.99640726
70EPHB10.96909803
71DYRK30.95629204
72EIF2AK10.93086894
73TEC0.92977742
74STK110.89961716
75CAMK2A0.89366768
76PTK2B0.88385866
77CAMK10.87682616
78PASK0.87140590
79ZAP700.85422311
80KDR0.84294884
81LATS10.82544113
82PAK30.82529709
83PNCK0.82479145
84CDK190.81955355
85NEK90.81617630
86WNK30.80923346
87PLK20.80833159
88BUB10.79677526
89JAK20.78894076
90EPHA40.77894318
91MAP3K10.77600787
92TGFBR10.77329570
93TNIK0.76275252
94CAMKK10.75756088
95OBSCN0.74581330
96NUAK10.74191244
97MKNK20.73824987
98STK30.72641058
99PKN10.72469015
100PRKCE0.72446732
101PIM20.69191196
102RPS6KA60.69085426
103GRK50.67944112
104JAK30.67355237
105FGFR20.65752275
106CAMK1D0.65248454
107CAMK2B0.64782867
108MARK30.64723925
109STK160.64340028
110ABL20.62388217
111MAP3K90.61971938
112TYK20.61261945
113CSNK1G10.59748913
114PRKD20.59028011
115SGK10.58868748
116BMPR1B0.58827229
117MAP2K10.58210112
118SIK20.58138037
119PRKCZ0.57642000
120WNK10.57466674
121CSNK1A1L0.56919954
122MAP2K60.56750565
123PRKACA0.56724195
124BLK0.55516647
125PRKAA10.54594340
126VRK10.54197793
127CAMK40.53619607
128CSNK1A10.52983911
129PRKCQ0.52822547
130CSNK1G30.52739538
131ITK0.52585328
132CSNK1G20.52518549
133ERBB20.52252838
134TBK10.51738065
135CDK50.51336285
136IRAK40.50516032
137GRK70.50166826
138NEK20.49451522
139PRKAA20.49210688
140CHUK0.47149844
141MAP2K20.47051520
142PAK60.45744062
143STK240.45696013
144CAMK2G0.45157178
145PTK20.44905624
146RPS6KA50.44726944
147CAMK2D0.44642628
148CAMK1G0.44380716
149DYRK20.43921795
150FGR0.43789047
151TIE10.43251931
152STK380.42643552
153TESK10.42157917
154STK100.40891480
155SGK30.40763444
156FGFR40.40596677
157TYRO30.39683355
158CSK0.39534027
159PRKCI0.39386051
160IKBKE0.38865142
161CSNK1D0.38307986
162DYRK1B0.37996585
163MARK20.37926737
164PDPK10.37729110
165PRKCH0.37719678
166IKBKB0.37594940
167PRKCA0.37298951
168MAP3K70.37256487
169DYRK1A0.36909831
170RPS6KA30.36534102

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.81040635
2Maturity onset diabetes of the young_Homo sapiens_hsa049505.10211188
3Sulfur metabolism_Homo sapiens_hsa009204.14223901
4Nicotine addiction_Homo sapiens_hsa050333.34970153
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.80198345
6Folate biosynthesis_Homo sapiens_hsa007902.66664735
7Phototransduction_Homo sapiens_hsa047442.52256407
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.33147715
9Vitamin B6 metabolism_Homo sapiens_hsa007502.31708447
10Lysosome_Homo sapiens_hsa041422.31634100
11Regulation of autophagy_Homo sapiens_hsa041402.31267044
12Morphine addiction_Homo sapiens_hsa050322.25195742
13Sphingolipid metabolism_Homo sapiens_hsa006002.24421304
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.18162713
15Vibrio cholerae infection_Homo sapiens_hsa051102.15837951
16Fatty acid elongation_Homo sapiens_hsa000622.00739130
17Circadian entrainment_Homo sapiens_hsa047131.94946312
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.89559650
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.87102556
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.86068133
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.81076508
22Oxidative phosphorylation_Homo sapiens_hsa001901.80123337
23GABAergic synapse_Homo sapiens_hsa047271.76581496
24Glutamatergic synapse_Homo sapiens_hsa047241.72413943
25Taste transduction_Homo sapiens_hsa047421.72362974
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.64716577
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.56976708
28Collecting duct acid secretion_Homo sapiens_hsa049661.49341303
29N-Glycan biosynthesis_Homo sapiens_hsa005101.46749179
30Other glycan degradation_Homo sapiens_hsa005111.45472709
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.39513744
32Olfactory transduction_Homo sapiens_hsa047401.38691003
33Salivary secretion_Homo sapiens_hsa049701.36540907
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.36477068
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36050949
36Ether lipid metabolism_Homo sapiens_hsa005651.35063815
37Cocaine addiction_Homo sapiens_hsa050301.34492802
38Dopaminergic synapse_Homo sapiens_hsa047281.33258039
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.32698099
40Histidine metabolism_Homo sapiens_hsa003401.29616949
41Cholinergic synapse_Homo sapiens_hsa047251.29059857
42Calcium signaling pathway_Homo sapiens_hsa040201.28225894
43Amphetamine addiction_Homo sapiens_hsa050311.26139676
44Butanoate metabolism_Homo sapiens_hsa006501.22153690
45Cardiac muscle contraction_Homo sapiens_hsa042601.19303435
46Peroxisome_Homo sapiens_hsa041461.17555781
47Glycerophospholipid metabolism_Homo sapiens_hsa005641.14828109
48Gastric acid secretion_Homo sapiens_hsa049711.12514501
49RNA polymerase_Homo sapiens_hsa030201.10859382
50Selenocompound metabolism_Homo sapiens_hsa004501.10115562
51Linoleic acid metabolism_Homo sapiens_hsa005911.07828719
52Caffeine metabolism_Homo sapiens_hsa002321.07219660
53Rheumatoid arthritis_Homo sapiens_hsa053231.05251657
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04468514
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99347577
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.98920610
57Proteasome_Homo sapiens_hsa030500.98722820
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.98213749
59Arachidonic acid metabolism_Homo sapiens_hsa005900.96870152
60Parkinsons disease_Homo sapiens_hsa050120.96242295
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95590850
62Oxytocin signaling pathway_Homo sapiens_hsa049210.93442541
63Arginine and proline metabolism_Homo sapiens_hsa003300.91874253
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91562135
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90264034
66Alzheimers disease_Homo sapiens_hsa050100.90243447
67Chemical carcinogenesis_Homo sapiens_hsa052040.90070856
68cAMP signaling pathway_Homo sapiens_hsa040240.88813006
69Propanoate metabolism_Homo sapiens_hsa006400.88570019
70Circadian rhythm_Homo sapiens_hsa047100.88499343
71Antigen processing and presentation_Homo sapiens_hsa046120.88376898
72Long-term depression_Homo sapiens_hsa047300.88288716
73Vitamin digestion and absorption_Homo sapiens_hsa049770.88170772
74Steroid biosynthesis_Homo sapiens_hsa001000.87682506
75Renin secretion_Homo sapiens_hsa049240.85285662
76Fatty acid biosynthesis_Homo sapiens_hsa000610.84093213
77Phagosome_Homo sapiens_hsa041450.82993780
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81125538
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.80799581
80Homologous recombination_Homo sapiens_hsa034400.80744395
81Fatty acid degradation_Homo sapiens_hsa000710.80172498
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78431194
83Pancreatic secretion_Homo sapiens_hsa049720.77940857
84Synaptic vesicle cycle_Homo sapiens_hsa047210.77112245
85Type II diabetes mellitus_Homo sapiens_hsa049300.76568964
86Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.76456847
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76085080
88Retinol metabolism_Homo sapiens_hsa008300.75943318
89Metabolic pathways_Homo sapiens_hsa011000.74522140
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73730269
91Fatty acid metabolism_Homo sapiens_hsa012120.66734389
92Insulin secretion_Homo sapiens_hsa049110.65296609
93Glutathione metabolism_Homo sapiens_hsa004800.64311704
94Glycerolipid metabolism_Homo sapiens_hsa005610.62111897
95Prion diseases_Homo sapiens_hsa050200.61156942
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60439060
97Axon guidance_Homo sapiens_hsa043600.60270856
98Basal cell carcinoma_Homo sapiens_hsa052170.59276821
99Huntingtons disease_Homo sapiens_hsa050160.58971923
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58174516
101Mineral absorption_Homo sapiens_hsa049780.54529214
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54027307
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53849878
104Endocytosis_Homo sapiens_hsa041440.53779273
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53235701
106Protein digestion and absorption_Homo sapiens_hsa049740.51780146
107Hedgehog signaling pathway_Homo sapiens_hsa043400.51619585
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51408070
109Pyruvate metabolism_Homo sapiens_hsa006200.51117366
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50429278
111MAPK signaling pathway_Homo sapiens_hsa040100.50196427
112Tryptophan metabolism_Homo sapiens_hsa003800.49339135
113Renin-angiotensin system_Homo sapiens_hsa046140.47943596
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47913368
115Fanconi anemia pathway_Homo sapiens_hsa034600.47131980
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46103302
117Bile secretion_Homo sapiens_hsa049760.45394803
118Pentose phosphate pathway_Homo sapiens_hsa000300.45155474
119Alcoholism_Homo sapiens_hsa050340.43035348
120Ras signaling pathway_Homo sapiens_hsa040140.41885452
121Thyroid hormone synthesis_Homo sapiens_hsa049180.41110110
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40750724
123beta-Alanine metabolism_Homo sapiens_hsa004100.39728726
124Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39646977
125Renal cell carcinoma_Homo sapiens_hsa052110.39352316
126Basal transcription factors_Homo sapiens_hsa030220.38872182
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38822417
128Type I diabetes mellitus_Homo sapiens_hsa049400.37286233
129Sulfur relay system_Homo sapiens_hsa041220.36318161
130Nitrogen metabolism_Homo sapiens_hsa009100.35323373
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35008375
132Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33977472
133Malaria_Homo sapiens_hsa051440.31912544
134Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31900898
135Vascular smooth muscle contraction_Homo sapiens_hsa042700.31131578
136Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30722118
137Tyrosine metabolism_Homo sapiens_hsa003500.30055892
138p53 signaling pathway_Homo sapiens_hsa041150.29491201
139Glycosaminoglycan degradation_Homo sapiens_hsa005310.29353512
140Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.29100455
141Shigellosis_Homo sapiens_hsa051310.29089129
142Ovarian steroidogenesis_Homo sapiens_hsa049130.27871012
143Fat digestion and absorption_Homo sapiens_hsa049750.27163531
144Sphingolipid signaling pathway_Homo sapiens_hsa040710.24084946
145Serotonergic synapse_Homo sapiens_hsa047260.21746774
146Primary bile acid biosynthesis_Homo sapiens_hsa001200.21663065
147PPAR signaling pathway_Homo sapiens_hsa033200.20114649
148ABC transporters_Homo sapiens_hsa020100.18604435
149Inositol phosphate metabolism_Homo sapiens_hsa005620.16902558
150Dorso-ventral axis formation_Homo sapiens_hsa043200.12754416
151Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.11611439
152Phenylalanine metabolism_Homo sapiens_hsa003600.11089435

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