YIPF6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)9.31918139
2Golgi transport vesicle coating (GO:0048200)9.31918139
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.90628064
4COPII vesicle coating (GO:0048208)5.82780593
5retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.67435509
6signal peptide processing (GO:0006465)5.34532735
7protein retention in ER lumen (GO:0006621)5.13877344
8ER overload response (GO:0006983)5.06656311
9endocrine pancreas development (GO:0031018)5.02661871
10regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.80919175
11exocrine pancreas development (GO:0031017)4.70257932
12peptide hormone processing (GO:0016486)4.60750272
13activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.56334600
14type B pancreatic cell development (GO:0003323)4.48662588
15vesicle coating (GO:0006901)4.44655209
16positive regulation of nuclease activity (GO:0032075)4.30462242
17UDP-N-acetylglucosamine metabolic process (GO:0006047)4.30455141
18sequestering of metal ion (GO:0051238)4.14263824
19ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.02547701
20glandular epithelial cell differentiation (GO:0002067)4.00776140
21endoplasmic reticulum unfolded protein response (GO:0030968)4.00332931
22protein maturation by protein folding (GO:0022417)3.96172533
23cellular response to unfolded protein (GO:0034620)3.95752721
24regulation of nuclease activity (GO:0032069)3.89026874
25ER-nucleus signaling pathway (GO:0006984)3.84012155
26cellular response to topologically incorrect protein (GO:0035967)3.76513269
27intra-Golgi vesicle-mediated transport (GO:0006891)3.60989449
28regulation of type B pancreatic cell apoptotic process (GO:2000674)3.54276573
29glandular epithelial cell development (GO:0002068)3.44804921
30response to endoplasmic reticulum stress (GO:0034976)3.39792994
313-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.36600490
32purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.36600490
33intestinal cholesterol absorption (GO:0030299)3.35707276
34insulin secretion (GO:0030073)3.31658348
35ER to Golgi vesicle-mediated transport (GO:0006888)3.29915364
36dopamine transport (GO:0015872)3.29513306
37protein N-linked glycosylation via asparagine (GO:0018279)3.25683115
38peptidyl-asparagine modification (GO:0018196)3.24519712
39Golgi organization (GO:0007030)3.21487930
40positive regulation of insulin secretion (GO:0032024)3.12762323
41protein targeting to Golgi (GO:0000042)3.11858938
42macroautophagy (GO:0016236)3.03647019
43* columnar/cuboidal epithelial cell development (GO:0002066)3.03068216
44prostate gland growth (GO:0060736)3.02630317
45surfactant homeostasis (GO:0043129)3.02461532
46transcytosis (GO:0045056)3.01008817
47protein N-linked glycosylation (GO:0006487)2.98653223
48response to unfolded protein (GO:0006986)2.96377907
49positive regulation of glycolytic process (GO:0045821)2.95181116
50nucleotide transmembrane transport (GO:1901679)2.93911087
51cellular ketone body metabolic process (GO:0046950)2.88942709
52response to topologically incorrect protein (GO:0035966)2.84720181
53regulation of insulin secretion (GO:0050796)2.84366067
54regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.81775912
55negative regulation of glycoprotein biosynthetic process (GO:0010561)2.80776364
56L-alpha-amino acid transmembrane transport (GO:1902475)2.80411142
57protein localization to Golgi apparatus (GO:0034067)2.79842973
58retrograde transport, vesicle recycling within Golgi (GO:0000301)2.78944298
59intestinal absorption (GO:0050892)2.75695833
60toxin metabolic process (GO:0009404)2.74235619
61establishment of protein localization to Golgi (GO:0072600)2.72664682
62regulation of acyl-CoA biosynthetic process (GO:0050812)2.68307665
63L-phenylalanine catabolic process (GO:0006559)2.67766847
64erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.67766847
65endoplasmic reticulum organization (GO:0007029)2.65698807
66pyrimidine-containing compound transmembrane transport (GO:0072531)2.65398396
67behavioral response to nicotine (GO:0035095)2.65090284
68Golgi vesicle transport (GO:0048193)2.64545376
69cellular response to vitamin D (GO:0071305)2.63441485
70regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.60730333
71positive regulation of peptide hormone secretion (GO:0090277)2.59740830
72regulation of hexokinase activity (GO:1903299)2.59252876
73regulation of glucokinase activity (GO:0033131)2.59252876
74negative regulation of cytosolic calcium ion concentration (GO:0051481)2.58865007
75intraciliary transport (GO:0042073)2.58791104
76positive regulation of hormone biosynthetic process (GO:0046886)2.58286216
77magnesium ion transport (GO:0015693)2.57589805
78regulation of peptide hormone secretion (GO:0090276)2.57427359
79cellular response to hepatocyte growth factor stimulus (GO:0035729)2.56694800
80response to hepatocyte growth factor (GO:0035728)2.56694800
81epithelial cilium movement (GO:0003351)2.54860000
82negative regulation of glycogen biosynthetic process (GO:0045719)2.54449792
83regulation of peptide secretion (GO:0002791)2.52707445
84positive regulation of peptide secretion (GO:0002793)2.50904287
85zinc ion transport (GO:0006829)2.50878144
86sphingosine metabolic process (GO:0006670)2.50660717
87ketone body metabolic process (GO:1902224)2.50484098
88positive regulation of steroid biosynthetic process (GO:0010893)2.50330928
89peptide catabolic process (GO:0043171)2.50126583
90dopamine biosynthetic process (GO:0042416)2.49786964
91nitric oxide mediated signal transduction (GO:0007263)2.48385360
92chemical homeostasis within a tissue (GO:0048875)2.48318856
93response to pheromone (GO:0019236)2.48212892
94peptide secretion (GO:0002790)2.48187569
95interleukin-1-mediated signaling pathway (GO:0070498)2.47836233
96nonmotile primary cilium assembly (GO:0035058)2.45905209
97hormone catabolic process (GO:0042447)2.45429929
98nucleotide-sugar metabolic process (GO:0009225)2.45105842
99cellular zinc ion homeostasis (GO:0006882)2.44216907
100epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.44156601
101epithelial cell maturation (GO:0002070)2.43071335
102response to redox state (GO:0051775)2.41592695
103regulation of protein glycosylation (GO:0060049)2.41153849
104regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.38746454
105peptide hormone secretion (GO:0030072)2.38635276
106respiratory chain complex IV assembly (GO:0008535)2.38099610
107nucleotide-sugar biosynthetic process (GO:0009226)2.37924032
108protein localization to cilium (GO:0061512)2.37729021
109pancreas development (GO:0031016)2.37313371
110water-soluble vitamin biosynthetic process (GO:0042364)2.36147675
111cilium organization (GO:0044782)2.36070563
112regulation of sulfur metabolic process (GO:0042762)2.35666663
113cilium assembly (GO:0042384)2.34158196
114keratan sulfate catabolic process (GO:0042340)2.33922714
1154-hydroxyproline metabolic process (GO:0019471)2.32377549
116kidney morphogenesis (GO:0060993)2.32356241
117regulation of hormone secretion (GO:0046883)2.31927983
118mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.31553006
119cilium morphogenesis (GO:0060271)2.31295513
120L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.29094791
121positive regulation of hormone secretion (GO:0046887)2.28787006
122negative regulation of keratinocyte proliferation (GO:0010839)2.27902669
123atrial cardiac muscle cell action potential (GO:0086014)2.27596675
124regulation of cofactor metabolic process (GO:0051193)2.26923189
125regulation of coenzyme metabolic process (GO:0051196)2.26923189
126branched-chain amino acid catabolic process (GO:0009083)2.26853760
127somite rostral/caudal axis specification (GO:0032525)2.21610933
128kynurenine metabolic process (GO:0070189)2.21044059
129keratinocyte development (GO:0003334)2.20885671
130cilium movement (GO:0003341)2.20301870
131detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.19999109
132polyol catabolic process (GO:0046174)2.19932389
133auditory receptor cell differentiation (GO:0042491)2.18393499
134protein K6-linked ubiquitination (GO:0085020)2.14559195
135regulation of cilium movement (GO:0003352)2.11978614
136catecholamine transport (GO:0051937)2.08544776
137thyroid hormone metabolic process (GO:0042403)2.07328558
138acrosome assembly (GO:0001675)2.06127846
139reflex (GO:0060004)2.05838284
140indolalkylamine metabolic process (GO:0006586)2.05370446
141detection of light stimulus involved in visual perception (GO:0050908)2.03040075
142detection of light stimulus involved in sensory perception (GO:0050962)2.03040075
143phenol-containing compound catabolic process (GO:0019336)2.02889473
144protein complex biogenesis (GO:0070271)2.02876082
145amino acid salvage (GO:0043102)2.02552475
146L-methionine salvage (GO:0071267)2.02552475
147L-methionine biosynthetic process (GO:0071265)2.02552475
148limb development (GO:0060173)2.02071688
149appendage development (GO:0048736)2.02071688
150inositol phosphate catabolic process (GO:0071545)2.01579061
151protein prenylation (GO:0018342)2.01232603
152prenylation (GO:0097354)2.01232603
153tryptophan catabolic process (GO:0006569)2.00347732
154indole-containing compound catabolic process (GO:0042436)2.00347732
155indolalkylamine catabolic process (GO:0046218)2.00347732
156regulation of acrosome reaction (GO:0060046)2.00259284
157aromatic amino acid family catabolic process (GO:0009074)2.00183543
158regulation of hippo signaling (GO:0035330)1.98612916
159regulation of mesoderm development (GO:2000380)1.98486946
160nephron epithelium morphogenesis (GO:0072088)1.96908310
161nephron tubule morphogenesis (GO:0072078)1.96908310
162vascular smooth muscle contraction (GO:0014829)1.96297418
163tryptophan metabolic process (GO:0006568)1.95280953
164presynaptic membrane assembly (GO:0097105)1.94858028
165protein neddylation (GO:0045116)1.94798143
166protein polyglutamylation (GO:0018095)1.94605428
167cellular component assembly involved in morphogenesis (GO:0010927)1.93634469
168ribonucleoprotein complex disassembly (GO:0032988)1.92825087
169regulation of calcineurin-NFAT signaling cascade (GO:0070884)1.92053500
170platelet dense granule organization (GO:0060155)1.91227880
171positive regulation of protein autophosphorylation (GO:0031954)1.90280977
172lipid particle organization (GO:0034389)1.90176678
173S-adenosylmethionine metabolic process (GO:0046500)1.89516390
174cytochrome complex assembly (GO:0017004)1.89093362
175L-phenylalanine metabolic process (GO:0006558)1.88940109
176erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)1.88940109
177catechol-containing compound biosynthetic process (GO:0009713)1.88909548
178catecholamine biosynthetic process (GO:0042423)1.88909548
179photoreceptor cell maintenance (GO:0045494)1.88579519
180artery smooth muscle contraction (GO:0014824)1.87710507
181organelle disassembly (GO:1903008)1.87651958
182positive regulation of meiosis (GO:0045836)1.86629847
183mitochondrial respiratory chain complex assembly (GO:0033108)1.86487285
184phasic smooth muscle contraction (GO:0014821)1.86172442

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human3.32759961
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.89026197
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.71699004
4ZNF217_24962896_ChIP-Seq_MCF-7_Human2.43974240
5FUS_26573619_Chip-Seq_HEK293_Human2.40536213
6TAF15_26573619_Chip-Seq_HEK293_Human2.35814291
7ZNF274_21170338_ChIP-Seq_K562_Hela2.24918703
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14969210
9VDR_22108803_ChIP-Seq_LS180_Human2.11373650
10EWS_26573619_Chip-Seq_HEK293_Human2.09862839
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.08085497
12AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.05355410
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.03796506
14FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.01136050
15PIAS1_25552417_ChIP-Seq_VCAP_Human1.97094676
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.93136051
17* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.92655063
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.88870723
19GBX2_23144817_ChIP-Seq_PC3_Human1.82315630
20SOX2_20726797_ChIP-Seq_SW620_Human1.80943852
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.80764874
22FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.76788645
23AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.75946898
24NRF2_20460467_ChIP-Seq_MEFs_Mouse1.72437012
25NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.72437012
26RXR_22158963_ChIP-Seq_LIVER_Mouse1.69048316
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.68741636
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.62680314
29MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.62124549
30ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.58253262
31PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.57285959
32ELK1_19687146_ChIP-ChIP_HELA_Human1.56719585
33ER_23166858_ChIP-Seq_MCF-7_Human1.56384709
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.56276170
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54818459
36ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.53746598
37STAT3_23295773_ChIP-Seq_U87_Human1.51434122
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50058618
39IRF8_22096565_ChIP-ChIP_GC-B_Human1.48467984
40OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48415436
41ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48132276
42FOXM1_26456572_ChIP-Seq_MCF-7_Human1.47655379
43ESR1_20079471_ChIP-ChIP_T-47D_Human1.46309582
44NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.44885690
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43893832
46FOXA1_25552417_ChIP-Seq_VCAP_Human1.43295669
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.42987784
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.41711133
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40437447
50FOXA2_19822575_ChIP-Seq_HepG2_Human1.39728564
51SMAD4_21799915_ChIP-Seq_A2780_Human1.39254803
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38902026
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34968036
54SALL4_18804426_ChIP-ChIP_XEN_Mouse1.34605447
55IGF1R_20145208_ChIP-Seq_DFB_Human1.33770798
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.32988862
57TRIM28_21343339_ChIP-Seq_HEK293_Human1.32655253
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32646760
59CBP_20019798_ChIP-Seq_JUKART_Human1.32197546
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32197546
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31539603
62NANOG_18555785_Chip-Seq_ESCs_Mouse1.31009819
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29361669
64TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.29340898
65GATA4_25053715_ChIP-Seq_YYC3_Human1.28820993
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28476491
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28367924
68CDX2_22108803_ChIP-Seq_LS180_Human1.28174098
69FOXO3_23340844_ChIP-Seq_DLD1_Human1.27638410
70GABP_17652178_ChIP-ChIP_JURKAT_Human1.27390500
71BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.27150337
72EGR1_23403033_ChIP-Seq_LIVER_Mouse1.26612913
73BCAT_22108803_ChIP-Seq_LS180_Human1.25729719
74RXR_22108803_ChIP-Seq_LS180_Human1.25349463
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24013513
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23865965
77PPARA_22158963_ChIP-Seq_LIVER_Mouse1.22845483
78FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.22815770
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.22237927
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21967819
81KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21917381
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21845277
83ESR2_21235772_ChIP-Seq_MCF-7_Human1.21091050
84CJUN_26792858_Chip-Seq_BT549_Human1.20036183
85TP63_23658742_ChIP-Seq_EP156T_Human1.19993557
86AHR_22903824_ChIP-Seq_MCF-7_Human1.19376844
87P300_19829295_ChIP-Seq_ESCs_Human1.19169010
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18762692
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16465211
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16397486
91ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15395143
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15055124
93PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15022955
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14720652
95NANOG_19829295_ChIP-Seq_ESCs_Human1.14474880
96SOX2_19829295_ChIP-Seq_ESCs_Human1.14474880
97NFE2_27457419_Chip-Seq_LIVER_Mouse1.13801696
98GATA3_24758297_ChIP-Seq_MCF-7_Human1.12399878
99SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12023707
100TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11638743
101HTT_18923047_ChIP-ChIP_STHdh_Human1.10509917
102TCF4_23295773_ChIP-Seq_U87_Human1.09315587
103TCF4_22108803_ChIP-Seq_LS180_Human1.08982776
104CBX2_27304074_Chip-Seq_ESCs_Mouse1.08395516
105ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07407965
106AR_25329375_ChIP-Seq_VCAP_Human1.07126650
107STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06287610
108P53_22387025_ChIP-Seq_ESCs_Mouse1.05721684
109EZH2_27294783_Chip-Seq_NPCs_Mouse1.05664801
110STAT3_18555785_Chip-Seq_ESCs_Mouse1.05534509
111JUN_21703547_ChIP-Seq_K562_Human1.05357497
112EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04724218
113CMYC_18555785_Chip-Seq_ESCs_Mouse1.04714726
114FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03559416
115* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03198225
116RNF2_27304074_Chip-Seq_NSC_Mouse1.03169815
117P300_18555785_Chip-Seq_ESCs_Mouse1.02573160
118SOX2_18555785_Chip-Seq_ESCs_Mouse1.02468099
119SMAD3_21741376_ChIP-Seq_EPCs_Human1.02444743
120FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02241548
121FOXA1_25329375_ChIP-Seq_VCAP_Human1.02241548
122CRX_20693478_ChIP-Seq_RETINA_Mouse1.01634581
123EP300_21415370_ChIP-Seq_HL-1_Mouse1.01330688
124FLI1_21867929_ChIP-Seq_TH2_Mouse1.00937523
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00904651
126TP53_22573176_ChIP-Seq_HFKS_Human1.00571358
127YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00532296
128FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00409886
129CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00361475
130SOX2_21211035_ChIP-Seq_LN229_Gbm0.99986943
131SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98697110
132MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98640528
133SMAD4_21741376_ChIP-Seq_EPCs_Human0.98091016
134SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97974634
135CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97393032
136RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97148893
137FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.97060905
138CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96331677
139LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96101990
140E2F1_18555785_Chip-Seq_ESCs_Mouse0.95812430
141NMYC_18555785_Chip-Seq_ESCs_Mouse0.95029245
142* RUNX2_22187159_ChIP-Seq_PCA_Human0.94103909
143CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91996829
144TP53_18474530_ChIP-ChIP_U2OS_Human0.91872728
145* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91705417
146TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90318151

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo4.37203362
2MP0004043_abnormal_pH_regulation4.26917463
3MP0002877_abnormal_melanocyte_morpholog3.90297408
4MP0003183_abnormal_peptide_metabolism3.37266734
5MP0004264_abnormal_extraembryonic_tissu3.21062518
6MP0010386_abnormal_urinary_bladder3.19452485
7MP0002693_abnormal_pancreas_physiology3.17313177
8MP0005365_abnormal_bile_salt3.12359203
9MP0005220_abnormal_exocrine_pancreas3.11046063
10MP0002139_abnormal_hepatobiliary_system3.00313408
11MP0001944_abnormal_pancreas_morphology2.93140213
12MP0003283_abnormal_digestive_organ2.92086294
13MP0002909_abnormal_adrenal_gland2.89667256
14MP0003195_calcinosis2.82823496
15MP0005379_endocrine/exocrine_gland_phen2.74724783
16MP0001666_abnormal_nutrient_absorption2.67529920
17MP0003300_gastrointestinal_ulcer2.56974630
18MP0010234_abnormal_vibrissa_follicle2.56670555
19MP0003868_abnormal_feces_composition2.56587252
20MP0005085_abnormal_gallbladder_physiolo2.39147739
21MP0003252_abnormal_bile_duct2.14208085
22MP0002938_white_spotting2.07680341
23MP0005058_abnormal_lysosome_morphology2.04084512
24MP0004782_abnormal_surfactant_physiolog1.97290386
25MP0005646_abnormal_pituitary_gland1.97158607
26MP0008877_abnormal_DNA_methylation1.95275082
27MP0000569_abnormal_digit_pigmentation1.85328070
28MP0005408_hypopigmentation1.84593653
29MP0005310_abnormal_salivary_gland1.82569997
30MP0000462_abnormal_digestive_system1.82371439
31MP0000678_abnormal_parathyroid_gland1.79447328
32MP0009046_muscle_twitch1.79255955
33MP0002078_abnormal_glucose_homeostasis1.76286725
34MP0006054_spinal_hemorrhage1.74744545
35MP0000013_abnormal_adipose_tissue1.70882050
36MP0000613_abnormal_salivary_gland1.67224398
37MP0003136_yellow_coat_color1.62263505
38MP0001765_abnormal_ion_homeostasis1.60649291
39MP0002234_abnormal_pharynx_morphology1.60442751
40MP0005551_abnormal_eye_electrophysiolog1.59606014
41MP0008875_abnormal_xenobiotic_pharmacok1.57609346
42MP0009643_abnormal_urine_homeostasis1.57096443
43MP0002896_abnormal_bone_mineralization1.51477535
44MP0003937_abnormal_limbs/digits/tail_de1.49957888
45MP0003172_abnormal_lysosome_physiology1.47948212
46MP0003122_maternal_imprinting1.46587142
47MP0002876_abnormal_thyroid_physiology1.44466408
48MP0001756_abnormal_urination1.41454238
49MP0000631_abnormal_neuroendocrine_gland1.41343547
50MP0000372_irregular_coat_pigmentation1.40962052
51MP0003718_maternal_effect1.37788624
52MP0004147_increased_porphyrin_level1.36800032
53MP0000647_abnormal_sebaceous_gland1.36442654
54MP0002138_abnormal_hepatobiliary_system1.35506458
55MP0004215_abnormal_myocardial_fiber1.34539668
56MP0005253_abnormal_eye_physiology1.33756841
57MP0008057_abnormal_DNA_replication1.32786831
58MP0001346_abnormal_lacrimal_gland1.31787533
59MP0006292_abnormal_olfactory_placode1.31591787
60MP0000383_abnormal_hair_follicle1.31185718
61MP0002295_abnormal_pulmonary_circulatio1.29298788
62MP0004133_heterotaxia1.28976675
63MP0000003_abnormal_adipose_tissue1.24198233
64MP0005083_abnormal_biliary_tract1.23422840
65MP0002928_abnormal_bile_duct1.22506644
66MP0003806_abnormal_nucleotide_metabolis1.22244622
67MP0005636_abnormal_mineral_homeostasis1.20449209
68MP0002163_abnormal_gland_morphology1.19402280
69MP0003121_genomic_imprinting1.18993187
70MP0006276_abnormal_autonomic_nervous1.16950958
71MP0008004_abnormal_stomach_pH1.15432465
72MP0002233_abnormal_nose_morphology1.14151495
73MP0002118_abnormal_lipid_homeostasis1.13920933
74MP0001984_abnormal_olfaction1.13462759
75MP0010678_abnormal_skin_adnexa1.13315535
76MP0005248_abnormal_Harderian_gland1.09158968
77MP0002557_abnormal_social/conspecific_i1.08494231
78MP0003953_abnormal_hormone_level1.07357753
79MP0002160_abnormal_reproductive_system1.06585753
80MP0002638_abnormal_pupillary_reflex1.06523930
81MP0003123_paternal_imprinting1.03475090
82MP0008775_abnormal_heart_ventricle1.01510452
83MP0003045_fibrosis1.01252640
84MP0002102_abnormal_ear_morphology0.99485486
85MP0004270_analgesia0.99470264
86MP0006072_abnormal_retinal_apoptosis0.99280724
87MP0000778_abnormal_nervous_system0.98797739
88MP0005187_abnormal_penis_morphology0.97870412
89MP0001485_abnormal_pinna_reflex0.97520165
90MP0008789_abnormal_olfactory_epithelium0.97241392
91MP0001293_anophthalmia0.96755314
92MP0001177_atelectasis0.96513370
93MP0003011_delayed_dark_adaptation0.94810023
94MP0002272_abnormal_nervous_system0.93932292
95MP0004019_abnormal_vitamin_homeostasis0.93765834
96MP0001986_abnormal_taste_sensitivity0.93718602
97MP0003890_abnormal_embryonic-extraembry0.93648891
98MP0003119_abnormal_digestive_system0.93386334
99MP0010329_abnormal_lipoprotein_level0.92655124
100MP0005645_abnormal_hypothalamus_physiol0.92492170
101MP0000538_abnormal_urinary_bladder0.92221584
102MP0003941_abnormal_skin_development0.91350261
103MP0001270_distended_abdomen0.90946943
104MP0001299_abnormal_eye_distance/0.90709993
105MP0008872_abnormal_physiological_respon0.90706571
106MP0005257_abnormal_intraocular_pressure0.90254772
107MP0001529_abnormal_vocalization0.89018293
108MP0009745_abnormal_behavioral_response0.88858437
109MP0002736_abnormal_nociception_after0.87216898
110MP0008995_early_reproductive_senescence0.87050539
111MP0005386_behavior/neurological_phenoty0.86837289
112MP0004924_abnormal_behavior0.86837289
113MP0001664_abnormal_digestion0.86561341
114MP0004142_abnormal_muscle_tone0.86492013
115MP0003191_abnormal_cellular_cholesterol0.86415347
116MP0008961_abnormal_basal_metabolism0.85470862
117MP0001881_abnormal_mammary_gland0.84797817
118MP0004085_abnormal_heartbeat0.83946067
119MP0004145_abnormal_muscle_electrophysio0.83515517
120MP0002734_abnormal_mechanical_nocicepti0.81651299
121MP0002098_abnormal_vibrissa_morphology0.81033072
122MP0003755_abnormal_palate_morphology0.80700325
123MP0005395_other_phenotype0.80661904
124MP0000609_abnormal_liver_physiology0.80274821
125MP0000681_abnormal_thyroid_gland0.79913327
126MP0000230_abnormal_systemic_arterial0.76489945
127MP0002653_abnormal_ependyma_morphology0.74700088
128MP0005360_urolithiasis0.74261856
129MP0003186_abnormal_redox_activity0.73770164
130MP0005195_abnormal_posterior_eye0.73418365
131MP0005332_abnormal_amino_acid0.73406511
132MP0001968_abnormal_touch/_nociception0.71403407
133MP0005174_abnormal_tail_pigmentation0.71217194
134MP0003137_abnormal_impulse_conducting0.70385486
135MP0000639_abnormal_adrenal_gland0.70289511
136MP0003786_premature_aging0.69389030
137MP0000163_abnormal_cartilage_morphology0.68863196
138MP0001286_abnormal_eye_development0.68540562
139MP0009697_abnormal_copulation0.67807275
140MP0003787_abnormal_imprinting0.67804421
141MP0005535_abnormal_body_temperature0.67729973
142MP0000516_abnormal_urinary_system0.66604973
143MP0005367_renal/urinary_system_phenotyp0.66604973
144MP0010368_abnormal_lymphatic_system0.65956341
145MP0002837_dystrophic_cardiac_calcinosis0.64387888
146MP0005084_abnormal_gallbladder_morpholo0.63796824
147MP0004185_abnormal_adipocyte_glucose0.62250388
148MP0002009_preneoplasia0.61182714
149MP0002168_other_aberrant_phenotype0.60735168
150MP0004885_abnormal_endolymph0.60728420
151MP0003943_abnormal_hepatobiliary_system0.59647450
152MP0001661_extended_life_span0.59172670
153MP0003795_abnormal_bone_structure0.59031899
154MP0005334_abnormal_fat_pad0.58739964
155MP0000427_abnormal_hair_cycle0.58605812
156MP0002090_abnormal_vision0.58466865
157MP0000566_synostosis0.57985194
158MP0005448_abnormal_energy_balance0.57207342
159MP0000470_abnormal_stomach_morphology0.55300105
160MP0009642_abnormal_blood_homeostasis0.54968781
161MP0003690_abnormal_glial_cell0.53932436
162MP0003656_abnormal_erythrocyte_physiolo0.53637405

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)5.30722582
2Hyperinsulinemic hypoglycemia (HP:0000825)5.27848107
3Hypoglycemic coma (HP:0001325)4.83474008
4Symptomatic seizures (HP:0011145)4.78144521
5Insulin-resistant diabetes mellitus (HP:0000831)4.39854024
6Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.10325778
7Conjugated hyperbilirubinemia (HP:0002908)4.05920455
8Hyperglycemia (HP:0003074)3.92197713
9Urinary glycosaminoglycan excretion (HP:0003541)3.79635928
10Mucopolysacchariduria (HP:0008155)3.79635928
11Decreased circulating renin level (HP:0003351)3.66256706
12Abnormality of the intrinsic pathway (HP:0010989)3.61725194
13Hyperactive renin-angiotensin system (HP:0000841)3.60596819
14Abnormality of mucopolysaccharide metabolism (HP:0011020)3.55506750
15Abnormality of polysaccharide metabolism (HP:0011012)3.55506750
16Abnormality of glycosaminoglycan metabolism (HP:0004371)3.55506750
17Dysostosis multiplex (HP:0000943)3.50692321
18Ketoacidosis (HP:0001993)3.38772642
19Pancreatic cysts (HP:0001737)3.36433273
20Pancreatic fibrosis (HP:0100732)3.35129662
21Abnormality of endocrine pancreas physiology (HP:0012093)3.31551013
22Abnormality of the pancreatic islet cells (HP:0006476)3.31551013
23Abnormal pancreas size (HP:0012094)3.16602579
24Pancreatic islet-cell hyperplasia (HP:0004510)3.15786818
25True hermaphroditism (HP:0010459)3.11501872
26Generalized aminoaciduria (HP:0002909)3.11320788
27Exocrine pancreatic insufficiency (HP:0001738)3.00842894
28Abnormality of chloride homeostasis (HP:0011422)3.00299122
29Hypokalemia (HP:0002900)2.97950139
30Abnormality of calcium-phosphate metabolism (HP:0100530)2.97487651
31Abnormality of renin-angiotensin system (HP:0000847)2.97412866
32Abnormality of aromatic amino acid family metabolism (HP:0004338)2.92510503
33Abnormality of midbrain morphology (HP:0002418)2.90959150
34Molar tooth sign on MRI (HP:0002419)2.90959150
35Abnormality of the renal cortex (HP:0011035)2.90470716
36Medial flaring of the eyebrow (HP:0010747)2.90203002
37Epiphyseal dysplasia (HP:0002656)2.83577887
38Papillary thyroid carcinoma (HP:0002895)2.82936132
39Thoracolumbar scoliosis (HP:0002944)2.69423852
40Abnormality of the common coagulation pathway (HP:0010990)2.69084363
41Nephronophthisis (HP:0000090)2.68550580
42Protuberant abdomen (HP:0001538)2.65161754
43Fat malabsorption (HP:0002630)2.63481649
44Intrahepatic cholestasis (HP:0001406)2.61952719
45Abnormality of potassium homeostasis (HP:0011042)2.61536270
46Hyperkalemia (HP:0002153)2.59709795
47Agitation (HP:0000713)2.58772256
48Type II lissencephaly (HP:0007260)2.56635000
49Flat capital femoral epiphysis (HP:0003370)2.54139759
50Hyperventilation (HP:0002883)2.54137749
51Abdominal distention (HP:0003270)2.53202146
52Abnormality of the renal medulla (HP:0100957)2.50188638
53Gout (HP:0001997)2.49737505
54Proximal tubulopathy (HP:0000114)2.48538430
55Vacuolated lymphocytes (HP:0001922)2.42843118
56Tubular atrophy (HP:0000092)2.42418332
57Congenital primary aphakia (HP:0007707)2.42184775
58Gait imbalance (HP:0002141)2.42008256
59Irregular vertebral endplates (HP:0003301)2.38657125
60Congenital sensorineural hearing impairment (HP:0008527)2.38487676
61Abnormal foot bone ossification (HP:0010675)2.37339865
62Abnormal tarsal ossification (HP:0008369)2.36775525
63Osteomalacia (HP:0002749)2.36491879
64Retinal atrophy (HP:0001105)2.36331067
65Abnormality of purine metabolism (HP:0004352)2.29189569
66Large for gestational age (HP:0001520)2.28146009
67Pheochromocytoma (HP:0002666)2.26664840
68Disproportionate short-trunk short stature (HP:0003521)2.26534061
69Neuroendocrine neoplasm (HP:0100634)2.25576337
70Nephrogenic diabetes insipidus (HP:0009806)2.22663325
71Genital tract atresia (HP:0001827)2.21749396
72Hemiparesis (HP:0001269)2.20302139
73Limb dystonia (HP:0002451)2.19923825
74Vaginal atresia (HP:0000148)2.15601076
75Ketosis (HP:0001946)2.15144040
76Hypoplastic ischia (HP:0003175)2.14400772
77Drooling (HP:0002307)2.13786888
78Hyperphosphatemia (HP:0002905)2.13003438
79Hyperaldosteronism (HP:0000859)2.11826497
80Abnormality of alanine metabolism (HP:0010916)2.09696959
81Hyperalaninemia (HP:0003348)2.09696959
82Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.09696959
83Increased circulating renin level (HP:0000848)2.08581591
84Aplasia/Hypoplasia of the tibia (HP:0005772)2.07503852
85Aplasia/Hypoplasia of the tongue (HP:0010295)2.06727718
86Abnormality of the ischium (HP:0003174)2.06678780
87Thyroid carcinoma (HP:0002890)2.06671257
88Abnormality of liposaccharide metabolism (HP:0010968)2.06338491
89Abnormality of glycosphingolipid metabolism (HP:0004343)2.06338491
90Abnormality of glycolipid metabolism (HP:0010969)2.06338491
91Late onset (HP:0003584)2.05806836
92Steatorrhea (HP:0002570)2.05226073
93Furrowed tongue (HP:0000221)2.04325471
94Barrel-shaped chest (HP:0001552)2.00908058
95Abnormality of the vertebral endplates (HP:0005106)1.99479563
96Hypokalemic alkalosis (HP:0001949)1.99252036
97Chronic bronchitis (HP:0004469)1.98587935
98Gaze-evoked nystagmus (HP:0000640)1.98155486
99Insulin resistance (HP:0000855)1.97693831
100Small epiphyses (HP:0010585)1.97166330
101Male pseudohermaphroditism (HP:0000037)1.95523697
102Intestinal atresia (HP:0011100)1.95354607
103Broad-based gait (HP:0002136)1.94678806
104Abnormal drinking behavior (HP:0030082)1.94180347
105Polydipsia (HP:0001959)1.94180347
106Acute necrotizing encephalopathy (HP:0006965)1.92173018
107Fair hair (HP:0002286)1.91515835
108Unilateral renal agenesis (HP:0000122)1.89900908
109Abnormal biliary tract morphology (HP:0012440)1.89530411
110Progressive neurologic deterioration (HP:0002344)1.88232595
111Hypoplastic labia majora (HP:0000059)1.87625737
112Limb hypertonia (HP:0002509)1.87246811
113Congenital, generalized hypertrichosis (HP:0004540)1.86749424
114Abnormality of urine glucose concentration (HP:0011016)1.86497776
115Glycosuria (HP:0003076)1.86497776
116Cystic liver disease (HP:0006706)1.86225097
117Progressive macrocephaly (HP:0004481)1.86066653
118Hypothermia (HP:0002045)1.85721625
119Villous atrophy (HP:0011473)1.85270445
120Abnormality of small intestinal villus morphology (HP:0011472)1.85270445
121Papilledema (HP:0001085)1.83492152
122Sclerocornea (HP:0000647)1.81790157
123Increased CSF lactate (HP:0002490)1.80519406
124Postaxial foot polydactyly (HP:0001830)1.80268216
125Aplasia/Hypoplasia of the fovea (HP:0008060)1.79190501
126Hypoplasia of the fovea (HP:0007750)1.79190501
127Chronic diarrhea (HP:0002028)1.78682851
128Abnormal ciliary motility (HP:0012262)1.78123465
129Absent eyebrow (HP:0002223)1.77737165
130Cerebellar dysplasia (HP:0007033)1.76368943
131Acute encephalopathy (HP:0006846)1.76023791
132Epileptiform EEG discharges (HP:0011182)1.74796186
133Metaphyseal irregularity (HP:0003025)1.74568775
134Excessive salivation (HP:0003781)1.73629726
135Poor coordination (HP:0002370)1.73448870
136Rhinitis (HP:0012384)1.73329450
137Hypsarrhythmia (HP:0002521)1.73241730
138Hypomagnesemia (HP:0002917)1.73227996
139Optic nerve hypoplasia (HP:0000609)1.72869330
140Cortical dysplasia (HP:0002539)1.71781094
141Chronic hepatic failure (HP:0100626)1.71393387
142Acne (HP:0001061)1.70957958
143Tachypnea (HP:0002789)1.70404603
144Absent/shortened dynein arms (HP:0200106)1.70124155
145Dynein arm defect of respiratory motile cilia (HP:0012255)1.70124155
146Increased CSF protein (HP:0002922)1.69423915
147Abnormality of monocarboxylic acid metabolism (HP:0010996)1.69016391
148Volvulus (HP:0002580)1.68651767
149Hepatic necrosis (HP:0002605)1.68561379
150Abnormality of the pons (HP:0007361)1.68529265
151Calf muscle hypertrophy (HP:0008981)1.67379522
152Hypophosphatemia (HP:0002148)1.67367755
153Beaking of vertebral bodies (HP:0004568)1.67278034
154Dyskinesia (HP:0100660)1.66908487
155Hypoplasia of the pons (HP:0012110)1.66129028
156Postaxial hand polydactyly (HP:0001162)1.64690413
157Mitochondrial inheritance (HP:0001427)1.64363582
158Renal salt wasting (HP:0000127)1.64350953
159Adrenal hypoplasia (HP:0000835)1.63785219
160Abnormality of the labia majora (HP:0012881)1.63781970
161Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63722382
162Macroorchidism (HP:0000053)1.63374214
163Scrotal hypoplasia (HP:0000046)1.62452413
164Elevated alkaline phosphatase (HP:0003155)1.62105028
165Ovoid vertebral bodies (HP:0003300)1.60877805
166Hyperparathyroidism (HP:0000843)1.60543522
167Neoplasm of the adrenal gland (HP:0100631)1.60155422
168Renal cortical cysts (HP:0000803)1.60146536
169Abnormal respiratory motile cilium morphology (HP:0005938)1.59838577
170Abnormal respiratory epithelium morphology (HP:0012253)1.59838577
171Abnormality of the fovea (HP:0000493)1.59693978
172Short tibia (HP:0005736)1.57682499
173EEG with generalized epileptiform discharges (HP:0011198)1.57681980
174Abnormal biliary tract physiology (HP:0012439)1.57344374
175Bile duct proliferation (HP:0001408)1.57344374
176Hypotension (HP:0002615)1.57214349
177Hypokinesia (HP:0002375)1.56540034
178Lissencephaly (HP:0001339)1.56249253
179Prolonged partial thromboplastin time (HP:0003645)1.56116323
180Lipid accumulation in hepatocytes (HP:0006561)1.55727101
181Increased hepatocellular lipid droplets (HP:0006565)1.55407377
182Febrile seizures (HP:0002373)1.55406816

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK35.20463559
2INSRR4.86939144
3FRK4.52334266
4LATS13.08481926
5MAPK152.91462444
6CASK2.63828561
7AKT32.57579920
8PNCK2.54836751
9PASK2.51055281
10MAP3K22.49839787
11NUAK12.01406056
12MST41.88410270
13PRKD31.85882430
14ZAK1.84888591
15HIPK21.84392265
16PHKG21.79302363
17PHKG11.79302363
18SIK11.79291886
19ERN11.72001558
20TRIM281.71443712
21ACVR1B1.69396199
22MET1.66563677
23MAP3K121.59153638
24GRK11.53220055
25MKNK21.52997186
26CAMKK21.45375298
27STK391.44211053
28WNK41.44106837
29PINK11.42080671
30NEK91.40469194
31CSNK1G11.36852887
32EIF2AK11.36456312
33EPHA31.35066937
34ADRBK21.34397785
35FLT31.30377677
36PLK21.29757629
37EIF2AK31.29311137
38MAP3K41.28923013
39MAP3K31.28642512
40LMTK21.22688800
41JAK11.20704410
42PLK31.18527516
43CSNK1G31.15077281
44SGK21.12004206
45NTRK11.11476855
46PIK3CA1.10467382
47MST1R1.08646997
48IRAK31.08596292
49SCYL21.08384661
50FGFR21.08185329
51PDGFRA1.07533256
52MAP4K21.05493991
53NLK1.04593428
54STK161.03002863
55STK38L1.00086805
56IRAK10.95764385
57NEK60.95594248
58MKNK10.95170871
59SGK2230.93939284
60SGK4940.93939284
61PAK30.93713888
62SRPK10.93576316
63OXSR10.92658682
64SGK30.92419162
65TLK10.92073680
66MAPK130.91027853
67EPHB10.89402676
68PRKCH0.86863059
69TTK0.85363442
70OBSCN0.84944840
71MARK10.84831610
72WNK30.81278440
73PRKCG0.80995876
74BUB10.80272118
75BCR0.79393681
76CAMK1D0.79167073
77PTK20.79006569
78CDC42BPA0.77662852
79PDGFRB0.77199376
80WEE10.77089320
81MAP3K10.76468683
82PRKCE0.76306414
83PRKG20.76160669
84JAK30.75694417
85STK30.73197436
86ERBB40.70989190
87FER0.69818981
88PLK10.67149108
89STK240.66094439
90BMPR1B0.65876888
91FGFR30.65197642
92PIK3CG0.64832301
93CAMK2D0.64716723
94PRKAA10.64091958
95RET0.63700791
96ERBB30.62894926
97NTRK30.62884247
98JAK20.62296194
99MYLK0.60501026
100WNK10.58850384
101CAMK2A0.58375094
102DAPK20.57591835
103MAP3K140.56788482
104BMPR20.56519744
105NEK10.56291486
106PTK60.54786761
107PTK2B0.53820914
108TGFBR20.53143318
109MAP2K70.52292632
110ADRBK10.52050751
111EPHA40.52026180
112ITK0.51943588
113IGF1R0.51768328
114ZAP700.51513824
115BCKDK0.51013492
116YES10.50971829
117CSNK1E0.50523202
118MAPKAPK50.50102857
119BRD40.49864350
120IRAK20.49487312
121CAMK1G0.48773172
122KSR20.48521524
123DYRK20.46070960
124CDK30.46051950
125PRKAA20.44768047
126MELK0.44753543
127BRAF0.44437691
128CSNK1A1L0.44428792
129FGFR10.44079001
130RIPK10.43964408
131CSNK1A10.43464804
132PDPK10.43452948
133CSNK1D0.43322832
134GSK3A0.43322057
135TGFBR10.43157324
136BRSK20.42445054
137TNIK0.42341418
138PBK0.41150237
139ERBB20.41043176
140LIMK10.40800670
141MINK10.40700866
142MAPKAPK30.39316221
143CHUK0.39216346
144TIE10.38884034
145IRAK40.38870094
146MAP3K90.38544618
147ATM0.37708214
148EPHA20.37505206
149TRPM70.37259308
150PRKCQ0.35196913
151MAP3K60.32705358
152MAP2K10.31143146
153CSNK1G20.30918701

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.65094417
2Protein export_Homo sapiens_hsa030604.78715226
3Sulfur metabolism_Homo sapiens_hsa009204.42879226
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.02277087
5Insulin secretion_Homo sapiens_hsa049112.09391154
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.06807296
7Oxidative phosphorylation_Homo sapiens_hsa001901.84683769
8Vibrio cholerae infection_Homo sapiens_hsa051101.80127022
9Lysosome_Homo sapiens_hsa041421.73827432
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.70794473
11Type II diabetes mellitus_Homo sapiens_hsa049301.67240906
12Selenocompound metabolism_Homo sapiens_hsa004501.47021938
13Folate biosynthesis_Homo sapiens_hsa007901.44432124
14Pancreatic secretion_Homo sapiens_hsa049721.44336009
15Other glycan degradation_Homo sapiens_hsa005111.43420114
16N-Glycan biosynthesis_Homo sapiens_hsa005101.39994065
17Carbohydrate digestion and absorption_Homo sapiens_hsa049731.39369615
18Parkinsons disease_Homo sapiens_hsa050121.33537616
19Basal transcription factors_Homo sapiens_hsa030221.29742278
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27293957
21ABC transporters_Homo sapiens_hsa020101.26711349
22Circadian rhythm_Homo sapiens_hsa047101.25850728
23Caffeine metabolism_Homo sapiens_hsa002321.25417459
24Retinol metabolism_Homo sapiens_hsa008301.21886075
25beta-Alanine metabolism_Homo sapiens_hsa004101.20173142
26Sphingolipid metabolism_Homo sapiens_hsa006001.14979062
27Homologous recombination_Homo sapiens_hsa034401.14912098
28Tryptophan metabolism_Homo sapiens_hsa003801.14138177
29Pyruvate metabolism_Homo sapiens_hsa006201.13935230
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12699899
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.11338101
32Phototransduction_Homo sapiens_hsa047441.11274182
33Type I diabetes mellitus_Homo sapiens_hsa049401.10280851
34Nitrogen metabolism_Homo sapiens_hsa009101.09991334
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.09294739
36Chemical carcinogenesis_Homo sapiens_hsa052041.09033002
37Huntingtons disease_Homo sapiens_hsa050161.05549258
38Non-homologous end-joining_Homo sapiens_hsa034501.04817974
39Regulation of autophagy_Homo sapiens_hsa041401.03219725
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02748393
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01998477
42Proteasome_Homo sapiens_hsa030501.01924713
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01460387
44Protein digestion and absorption_Homo sapiens_hsa049741.01132508
45Thyroid hormone synthesis_Homo sapiens_hsa049181.00473733
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97509191
47Mineral absorption_Homo sapiens_hsa049780.96711892
48Nicotine addiction_Homo sapiens_hsa050330.94893427
49Steroid biosynthesis_Homo sapiens_hsa001000.94736332
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93153825
51Fanconi anemia pathway_Homo sapiens_hsa034600.92951623
52Alzheimers disease_Homo sapiens_hsa050100.92642779
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90258134
54Histidine metabolism_Homo sapiens_hsa003400.90244305
55Arginine and proline metabolism_Homo sapiens_hsa003300.88533460
56Cardiac muscle contraction_Homo sapiens_hsa042600.88444140
57Prolactin signaling pathway_Homo sapiens_hsa049170.88325827
58RNA polymerase_Homo sapiens_hsa030200.87893497
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.86395575
60Insulin resistance_Homo sapiens_hsa049310.82691061
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82245011
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81755676
63Cocaine addiction_Homo sapiens_hsa050300.81668566
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80830423
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80733493
66Fatty acid degradation_Homo sapiens_hsa000710.79250778
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78273819
68Vitamin B6 metabolism_Homo sapiens_hsa007500.78027083
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77601745
70One carbon pool by folate_Homo sapiens_hsa006700.77361888
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76941088
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76421774
73Ovarian steroidogenesis_Homo sapiens_hsa049130.76367978
74Metabolic pathways_Homo sapiens_hsa011000.75602779
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74853538
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74575933
77Starch and sucrose metabolism_Homo sapiens_hsa005000.74197855
78Mismatch repair_Homo sapiens_hsa034300.73782014
79Butanoate metabolism_Homo sapiens_hsa006500.73777195
80Fat digestion and absorption_Homo sapiens_hsa049750.72729558
81Glutathione metabolism_Homo sapiens_hsa004800.69787869
82RNA degradation_Homo sapiens_hsa030180.68635312
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68519745
84Prostate cancer_Homo sapiens_hsa052150.68386460
85Dorso-ventral axis formation_Homo sapiens_hsa043200.67255523
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66157802
87Serotonergic synapse_Homo sapiens_hsa047260.65708422
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65623330
89Tyrosine metabolism_Homo sapiens_hsa003500.64883629
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.64738310
91Hippo signaling pathway_Homo sapiens_hsa043900.60137124
92Fatty acid biosynthesis_Homo sapiens_hsa000610.59520042
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59085354
94Renin-angiotensin system_Homo sapiens_hsa046140.58407823
95Peroxisome_Homo sapiens_hsa041460.58019464
96Ether lipid metabolism_Homo sapiens_hsa005650.57223374
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57066459
98Bile secretion_Homo sapiens_hsa049760.56564147
99Purine metabolism_Homo sapiens_hsa002300.55345856
100Fatty acid metabolism_Homo sapiens_hsa012120.54748711
101GABAergic synapse_Homo sapiens_hsa047270.54565355
102TGF-beta signaling pathway_Homo sapiens_hsa043500.54335808
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54019031
104Circadian entrainment_Homo sapiens_hsa047130.53081196
105Nucleotide excision repair_Homo sapiens_hsa034200.51265529
106Propanoate metabolism_Homo sapiens_hsa006400.48274274
107Fatty acid elongation_Homo sapiens_hsa000620.47393913
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.46924215
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45918774
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45282232
111Pancreatic cancer_Homo sapiens_hsa052120.43007874
112Endometrial cancer_Homo sapiens_hsa052130.42756688
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39974407
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39210601
115Cholinergic synapse_Homo sapiens_hsa047250.39035778
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39000962
117Adherens junction_Homo sapiens_hsa045200.38743090
118mTOR signaling pathway_Homo sapiens_hsa041500.38655492
119Linoleic acid metabolism_Homo sapiens_hsa005910.38423039
120Taste transduction_Homo sapiens_hsa047420.38032317
121Estrogen signaling pathway_Homo sapiens_hsa049150.37351302
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.36751590
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36425253
124Complement and coagulation cascades_Homo sapiens_hsa046100.36115649
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35240846
126FoxO signaling pathway_Homo sapiens_hsa040680.35204294
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34626799
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34583553
129Amphetamine addiction_Homo sapiens_hsa050310.34447418
130Lysine degradation_Homo sapiens_hsa003100.34064602
131Hepatitis C_Homo sapiens_hsa051600.32982589
132Inositol phosphate metabolism_Homo sapiens_hsa005620.32610454
133Collecting duct acid secretion_Homo sapiens_hsa049660.32607100
134Phagosome_Homo sapiens_hsa041450.32418085
135Glycerolipid metabolism_Homo sapiens_hsa005610.32273339
136Prion diseases_Homo sapiens_hsa050200.32018776
137Thyroid cancer_Homo sapiens_hsa052160.32000575
138Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31166078
139AMPK signaling pathway_Homo sapiens_hsa041520.28449065
140cGMP-PKG signaling pathway_Homo sapiens_hsa040220.27660062
141Rheumatoid arthritis_Homo sapiens_hsa053230.26979598
142cAMP signaling pathway_Homo sapiens_hsa040240.26456128
143Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25303210
144Galactose metabolism_Homo sapiens_hsa000520.24772036
145Dopaminergic synapse_Homo sapiens_hsa047280.24530229
146Glucagon signaling pathway_Homo sapiens_hsa049220.23999318
147Renal cell carcinoma_Homo sapiens_hsa052110.23893508
148Vitamin digestion and absorption_Homo sapiens_hsa049770.23592798

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »