

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | sarcomere organization (GO:0045214) | 8.40104059 |
| 2 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 7.87728276 |
| 3 | actin-myosin filament sliding (GO:0033275) | 7.64799793 |
| 4 | muscle filament sliding (GO:0030049) | 7.64799793 |
| 5 | cardiac myofibril assembly (GO:0055003) | 7.51592430 |
| 6 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 7.24063381 |
| 7 | myofibril assembly (GO:0030239) | 7.23714409 |
| 8 | regulation of skeletal muscle contraction (GO:0014819) | 6.98808917 |
| 9 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 6.91264958 |
| 10 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 6.90302406 |
| 11 | tricarboxylic acid cycle (GO:0006099) | 6.89178952 |
| 12 | skeletal muscle fiber development (GO:0048741) | 6.77699661 |
| 13 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 6.71095430 |
| 14 | plasma membrane repair (GO:0001778) | 6.44012779 |
| 15 | regulation of relaxation of muscle (GO:1901077) | 6.41193414 |
| 16 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 6.35830991 |
| 17 | actin-mediated cell contraction (GO:0070252) | 6.29279692 |
| 18 | cardiac muscle contraction (GO:0060048) | 6.20154782 |
| 19 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 6.18910020 |
| 20 | myotube cell development (GO:0014904) | 6.09858162 |
| 21 | regulation of actin filament-based movement (GO:1903115) | 5.83407877 |
| 22 | regulation of cell communication by electrical coupling (GO:0010649) | 5.80970502 |
| 23 | regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) | 5.69400043 |
| 24 | carnitine shuttle (GO:0006853) | 5.65569039 |
| 25 | regulation of acyl-CoA biosynthetic process (GO:0050812) | 5.64331658 |
| 26 | cardiac muscle cell development (GO:0055013) | 5.63657564 |
| 27 | glucan catabolic process (GO:0009251) | 5.62526927 |
| 28 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 5.59042135 |
| 29 | striated muscle contraction (GO:0006941) | 5.47861684 |
| 30 | actomyosin structure organization (GO:0031032) | 5.29841333 |
| 31 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 5.28385093 |
| 32 | cardiac cell development (GO:0055006) | 5.27299947 |
| 33 | regulation of sarcomere organization (GO:0060297) | 5.26777677 |
| 34 | cellular polysaccharide catabolic process (GO:0044247) | 5.25408465 |
| 35 | glucan biosynthetic process (GO:0009250) | 5.18744124 |
| 36 | glycogen biosynthetic process (GO:0005978) | 5.18744124 |
| 37 | ventricular cardiac muscle cell action potential (GO:0086005) | 5.14183615 |
| 38 | regulation of cofactor metabolic process (GO:0051193) | 5.13972162 |
| 39 | regulation of coenzyme metabolic process (GO:0051196) | 5.13972162 |
| 40 | muscle fiber development (GO:0048747) | 5.03492607 |
| 41 | creatine metabolic process (GO:0006600) | 4.98657820 |
| 42 | skeletal muscle contraction (GO:0003009) | 4.98564370 |
| 43 | fatty acid transmembrane transport (GO:1902001) | 4.97442533 |
| 44 | cardiac muscle hypertrophy (GO:0003300) | 4.91501501 |
| 45 | skeletal muscle tissue development (GO:0007519) | 4.90499947 |
| 46 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 4.88857810 |
| 47 | skeletal muscle tissue regeneration (GO:0043403) | 4.88348048 |
| 48 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.87339847 |
| 49 | response to stimulus involved in regulation of muscle adaptation (GO:0014874) | 4.82569454 |
| 50 | cardiac muscle tissue morphogenesis (GO:0055008) | 4.77171672 |
| 51 | heart trabecula formation (GO:0060347) | 4.76671526 |
| 52 | regulation of striated muscle contraction (GO:0006942) | 4.73796529 |
| 53 | polysaccharide catabolic process (GO:0000272) | 4.73443825 |
| 54 | striated muscle hypertrophy (GO:0014897) | 4.73423528 |
| 55 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.73209819 |
| 56 | heart contraction (GO:0060047) | 4.72960909 |
| 57 | heart process (GO:0003015) | 4.72960909 |
| 58 | actin filament-based movement (GO:0030048) | 4.67793732 |
| 59 | respiratory electron transport chain (GO:0022904) | 4.60784961 |
| 60 | regulation of membrane repolarization (GO:0060306) | 4.56236217 |
| 61 | adult heart development (GO:0007512) | 4.52031087 |
| 62 | electron transport chain (GO:0022900) | 4.46506653 |
| 63 | fructose metabolic process (GO:0006000) | 4.43305193 |
| 64 | ATP synthesis coupled proton transport (GO:0015986) | 4.42646038 |
| 65 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.42646038 |
| 66 | oxidative phosphorylation (GO:0006119) | 4.36642361 |
| 67 | muscle cell cellular homeostasis (GO:0046716) | 4.36080525 |
| 68 | muscle tissue morphogenesis (GO:0060415) | 4.35947702 |
| 69 | ventricular cardiac muscle tissue morphogenesis (GO:0055010) | 4.28765456 |
| 70 | skeletal muscle adaptation (GO:0043501) | 4.20951312 |
| 71 | carnitine transmembrane transport (GO:1902603) | 4.19638865 |
| 72 | muscle hypertrophy (GO:0014896) | 4.19087869 |
| 73 | regulation of sulfur metabolic process (GO:0042762) | 4.18841700 |
| 74 | glycogen metabolic process (GO:0005977) | 4.16805972 |
| 75 | 2-oxoglutarate metabolic process (GO:0006103) | 4.12210171 |
| 76 | cell communication involved in cardiac conduction (GO:0086065) | 4.08863291 |
| 77 | cellular glucan metabolic process (GO:0006073) | 4.08135493 |
| 78 | glucan metabolic process (GO:0044042) | 4.08135493 |
| 79 | gluconeogenesis (GO:0006094) | 4.06044241 |
| 80 | NADH metabolic process (GO:0006734) | 4.05272424 |
| 81 | response to activity (GO:0014823) | 4.03051603 |
| 82 | muscle organ morphogenesis (GO:0048644) | 4.02381154 |
| 83 | regulation of sequestering of triglyceride (GO:0010889) | 4.00442837 |
| 84 | regulation of cardiac muscle cell contraction (GO:0086004) | 3.98993228 |
| 85 | muscle cell fate commitment (GO:0042693) | 3.98752607 |
| 86 | muscle contraction (GO:0006936) | 3.92429303 |
| 87 | positive regulation of calcium ion transmembrane transporter activity (GO:1901021) | 3.92248955 |
| 88 | regulation of the force of heart contraction (GO:0002026) | 3.91557227 |
| 89 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.91329033 |
| 90 | ubiquinone biosynthetic process (GO:0006744) | 3.86605393 |
| 91 | muscle structure development (GO:0061061) | 3.84484905 |
| 92 | neuronal action potential propagation (GO:0019227) | 3.84471024 |
| 93 | carnitine transport (GO:0015879) | 3.83000654 |
| 94 | amino-acid betaine transport (GO:0015838) | 3.83000654 |
| 95 | muscle organ development (GO:0007517) | 3.82262386 |
| 96 | regulation of cardiac muscle contraction (GO:0055117) | 3.79103126 |
| 97 | IMP metabolic process (GO:0046040) | 3.76837930 |
| 98 | negative regulation of potassium ion transport (GO:0043267) | 3.76738185 |
| 99 | regulation of calcineurin-NFAT signaling cascade (GO:0070884) | 3.74901257 |
| 100 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 3.73951500 |
| 101 | response to muscle activity (GO:0014850) | 3.73840014 |
| 102 | relaxation of cardiac muscle (GO:0055119) | 3.73648005 |
| 103 | striated muscle atrophy (GO:0014891) | 3.73289625 |
| 104 | striated muscle adaptation (GO:0014888) | 3.71736132 |
| 105 | positive regulation of mitochondrial calcium ion concentration (GO:0051561) | 3.71229843 |
| 106 | cardiac muscle cell action potential involved in contraction (GO:0086002) | 3.70543278 |
| 107 | response to inactivity (GO:0014854) | 3.69448794 |
| 108 | positive regulation of myotube differentiation (GO:0010831) | 3.68744779 |
| 109 | cardiac muscle cell action potential (GO:0086001) | 3.68123649 |
| 110 | cardiac muscle adaptation (GO:0014887) | 3.67047920 |
| 111 | cardiac muscle hypertrophy in response to stress (GO:0014898) | 3.67047920 |
| 112 | muscle hypertrophy in response to stress (GO:0003299) | 3.67047920 |
| 113 | regulation of calcium ion transmembrane transporter activity (GO:1901019) | 3.66393445 |
| 114 | regulation of calcium ion transmembrane transport (GO:1903169) | 3.66393445 |
| 115 | negative regulation of calcium ion transmembrane transporter activity (GO:1901020) | 3.65180854 |
| 116 | negative regulation of calcium ion transmembrane transport (GO:1903170) | 3.65180854 |
| 117 | muscle system process (GO:0003012) | 3.65113684 |
| 118 | muscle adaptation (GO:0043500) | 3.63309032 |
| 119 | hexose biosynthetic process (GO:0019319) | 3.61420528 |
| 120 | cytidine deamination (GO:0009972) | 3.58584923 |
| 121 | cytidine metabolic process (GO:0046087) | 3.58584923 |
| 122 | cytidine catabolic process (GO:0006216) | 3.58584923 |
| 123 | striated muscle cell development (GO:0055002) | 3.57476407 |
| 124 | regulation of heart rate (GO:0002027) | 3.54214832 |
| 125 | myoblast fusion (GO:0007520) | 3.53284002 |
| 126 | succinate metabolic process (GO:0006105) | 3.52757699 |
| 127 | fatty acid beta-oxidation (GO:0006635) | 3.50888373 |
| 128 | positive regulation of cation channel activity (GO:2001259) | 3.50053859 |
| 129 | glycogen catabolic process (GO:0005980) | 3.48977399 |
| 130 | aspartate family amino acid catabolic process (GO:0009068) | 3.47259391 |
| 131 | regulation of ATPase activity (GO:0043462) | 3.47236985 |
| 132 | regulation of ATP catabolic process (GO:1903289) | 3.47236985 |
| 133 | negative regulation of protein localization to cell surface (GO:2000009) | 3.46664190 |
| 134 | regulation of skeletal muscle cell differentiation (GO:2001014) | 3.43434545 |
| 135 | neuromuscular synaptic transmission (GO:0007274) | 3.43338434 |
| 136 | ubiquinone metabolic process (GO:0006743) | 3.42840238 |
| 137 | cellular carbohydrate catabolic process (GO:0044275) | 3.41367548 |
| 138 | muscle atrophy (GO:0014889) | 3.40392374 |
| 139 | negative regulation of muscle contraction (GO:0045932) | 3.40209549 |
| 140 | striated muscle tissue development (GO:0014706) | 3.32230404 |
| 141 | myotube differentiation (GO:0014902) | 3.31954778 |
| 142 | muscle cell development (GO:0055001) | 3.24348018 |
| 143 | relaxation of muscle (GO:0090075) | 3.20785402 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 7.30366078 |
| 2 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 4.95754340 |
| 3 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 4.56900452 |
| 4 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 4.56613048 |
| 5 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 4.54917751 |
| 6 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 4.06803120 |
| 7 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 4.06803120 |
| 8 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 3.59726649 |
| 9 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 3.33358764 |
| 10 | ZNF263_19887448_ChIP-Seq_K562_Human | 3.05125947 |
| 11 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 2.96252240 |
| 12 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 2.86088260 |
| 13 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.84422454 |
| 14 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.75599609 |
| 15 | GATA4_21415370_ChIP-Seq_HL-1_Mouse | 2.36329702 |
| 16 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 2.34793663 |
| 17 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.34446012 |
| 18 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 2.31931477 |
| 19 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.17075431 |
| 20 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 2.15308312 |
| 21 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 2.12980081 |
| 22 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.00112701 |
| 23 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.92084932 |
| 24 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.91085878 |
| 25 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.87345638 |
| 26 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.84518552 |
| 27 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.81375716 |
| 28 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 1.78009797 |
| 29 | GATA1_22025678_ChIP-Seq_K562_Human | 1.71231978 |
| 30 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.59427471 |
| 31 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.51190730 |
| 32 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.50534126 |
| 33 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.49386433 |
| 34 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.47516527 |
| 35 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.43883373 |
| 36 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.43232372 |
| 37 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.42667909 |
| 38 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 1.42436351 |
| 39 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.41167338 |
| 40 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.40991468 |
| 41 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.37699550 |
| 42 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.35278711 |
| 43 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.32068909 |
| 44 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 1.30720188 |
| 45 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 1.29038588 |
| 46 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.28530525 |
| 47 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 1.27318400 |
| 48 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.27283246 |
| 49 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.26604903 |
| 50 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.26148037 |
| 51 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.22497673 |
| 52 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.21674129 |
| 53 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.17597251 |
| 54 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 1.15587972 |
| 55 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.14333923 |
| 56 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.13800403 |
| 57 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 1.12658238 |
| 58 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 1.12645864 |
| 59 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.12076665 |
| 60 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 1.09432888 |
| 61 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 1.08576401 |
| 62 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.08053290 |
| 63 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.06232610 |
| 64 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.04322573 |
| 65 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.04322573 |
| 66 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.04214346 |
| 67 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.03651870 |
| 68 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.03202076 |
| 69 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.02627757 |
| 70 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.02606513 |
| 71 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.02446225 |
| 72 | * KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.02402427 |
| 73 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.01455945 |
| 74 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.01352302 |
| 75 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 1.01179982 |
| 76 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 0.99565134 |
| 77 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 0.98529192 |
| 78 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 0.98433257 |
| 79 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.97640181 |
| 80 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.97073969 |
| 81 | TP63_22573176_ChIP-Seq_HFKS_Human | 0.96368676 |
| 82 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.95675297 |
| 83 | OCT4_20526341_ChIP-Seq_ESCs_Human | 0.94720747 |
| 84 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 0.94559457 |
| 85 | SMC3_22415368_ChIP-Seq_MEFs_Mouse | 0.93880498 |
| 86 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.93668668 |
| 87 | VDR_22108803_ChIP-Seq_LS180_Human | 0.93656974 |
| 88 | KDM2B_26808549_Chip-Seq_DND41_Human | 0.93620325 |
| 89 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.93122695 |
| 90 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.92519188 |
| 91 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.91205126 |
| 92 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.91205126 |
| 93 | GATA1_19941826_ChIP-Seq_K562_Human | 0.90335247 |
| 94 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.90276439 |
| 95 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 0.88147712 |
| 96 | CJUN_26792858_Chip-Seq_BT549_Human | 0.88057579 |
| 97 | CTCF_21964334_ChIP-Seq_BJAB-B_Human | 0.86316624 |
| 98 | ATF3_27146783_Chip-Seq_COLON_Human | 0.84978174 |
| 99 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.83228105 |
| 100 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.83090713 |
| 101 | P68_20966046_ChIP-Seq_HELA_Human | 0.82917914 |
| 102 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 0.82840429 |
| 103 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 0.82745977 |
| 104 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 0.82622758 |
| 105 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.82219822 |
| 106 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.82219822 |
| 107 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.81411534 |
| 108 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.81331336 |
| 109 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.80626435 |
| 110 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 0.79335513 |
| 111 | SA1_27219007_Chip-Seq_Bcells_Human | 0.79114662 |
| 112 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 0.78910878 |
| 113 | GATA2_19941826_ChIP-Seq_K562_Human | 0.78858561 |
| 114 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.78745249 |
| 115 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.78683643 |
| 116 | CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 0.78641061 |
| 117 | CTCF_21964334_Chip-Seq_Bcells_Human | 0.77846495 |
| 118 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.77569820 |
| 119 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 0.77312405 |
| 120 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 0.77182763 |
| 121 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.77154337 |
| 122 | PHF8_20622853_ChIP-Seq_HELA_Human | 0.77006515 |
| 123 | SMC1_22415368_ChIP-Seq_MEFs_Mouse | 0.76927075 |
| 124 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.75782025 |
| 125 | * CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.75774357 |
| 126 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.75489812 |
| 127 | * RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.75317768 |
| 128 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 0.75102605 |
| 129 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.74144320 |
| 130 | GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse | 0.73930878 |
| 131 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 0.73496602 |
| 132 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.73361018 |
| 133 | * MYC_27129775_Chip-Seq_CORNEA_Mouse | 0.73014223 |
| 134 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.72798230 |
| 135 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 0.72337316 |
| 136 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 0.71763129 |
| 137 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 0.71466844 |
| 138 | FUS_26573619_Chip-Seq_HEK293_Human | 0.71455120 |
| 139 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.71245690 |
| 140 | GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 0.70935794 |
| 141 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.70853517 |
| 142 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.70836465 |
| 143 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 0.70741335 |
| 144 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.70570371 |
| 145 | NFYB_21822215_ChIP-Seq_K562_Human | 0.70561034 |
| 146 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.69839019 |
| 147 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.69787517 |
| 148 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 0.69695445 |
| 149 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.69534086 |
| 150 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.68228439 |
| 151 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.67986562 |
| 152 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.67696965 |
| 153 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 0.66969900 |
| 154 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.66672308 |
| 155 | CBP_21632823_ChIP-Seq_H3396_Human | 0.66476334 |
| 156 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.66067074 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003646_muscle_fatigue | 6.30968950 |
| 2 | MP0002837_dystrophic_cardiac_calcinosis | 6.05736975 |
| 3 | MP0000751_myopathy | 5.44320469 |
| 4 | MP0004084_abnormal_cardiac_muscle | 5.03852767 |
| 5 | MP0000749_muscle_degeneration | 4.53176024 |
| 6 | MP0004215_abnormal_myocardial_fiber | 4.38555438 |
| 7 | MP0004036_abnormal_muscle_relaxation | 4.30094681 |
| 8 | MP0005330_cardiomyopathy | 3.75174145 |
| 9 | MP0004145_abnormal_muscle_electrophysio | 3.48091504 |
| 10 | MP0004087_abnormal_muscle_fiber | 3.26857888 |
| 11 | MP0004130_abnormal_muscle_cell | 3.12736957 |
| 12 | MP0002106_abnormal_muscle_physiology | 2.95889428 |
| 13 | MP0000750_abnormal_muscle_regeneration | 2.94339535 |
| 14 | MP0002972_abnormal_cardiac_muscle | 2.89848096 |
| 15 | MP0005620_abnormal_muscle_contractility | 2.86970153 |
| 16 | MP0004484_altered_response_of | 2.71883203 |
| 17 | MP0002269_muscular_atrophy | 2.64027602 |
| 18 | MP0008775_abnormal_heart_ventricle | 2.60827380 |
| 19 | MP0000747_muscle_weakness | 2.59122406 |
| 20 | MP0003137_abnormal_impulse_conducting | 2.57425721 |
| 21 | MP0000759_abnormal_skeletal_muscle | 2.42181572 |
| 22 | MP0001544_abnormal_cardiovascular_syste | 2.42001590 |
| 23 | MP0005385_cardiovascular_system_phenoty | 2.42001590 |
| 24 | MP0010630_abnormal_cardiac_muscle | 2.41965327 |
| 25 | MP0005369_muscle_phenotype | 2.40107977 |
| 26 | MP0006036_abnormal_mitochondrial_physio | 2.12680233 |
| 27 | MP0006138_congestive_heart_failure | 2.00642923 |
| 28 | MP0003221_abnormal_cardiomyocyte_apopto | 2.00261425 |
| 29 | MP0003828_pulmonary_edema | 1.92886224 |
| 30 | MP0004233_abnormal_muscle_weight | 1.88541099 |
| 31 | MP0004085_abnormal_heartbeat | 1.83481732 |
| 32 | MP0002332_abnormal_exercise_endurance | 1.79772961 |
| 33 | MP0004270_analgesia | 1.68809730 |
| 34 | MP0004510_myositis | 1.65039521 |
| 35 | MP0005666_abnormal_adipose_tissue | 1.56888099 |
| 36 | MP0003950_abnormal_plasma_membrane | 1.46856256 |
| 37 | MP0002127_abnormal_cardiovascular_syste | 1.44334450 |
| 38 | MP0004185_abnormal_adipocyte_glucose | 1.27040434 |
| 39 | MP0006035_abnormal_mitochondrial_morpho | 1.24118985 |
| 40 | MP0000343_altered_response_to | 1.22868598 |
| 41 | MP0005670_abnormal_white_adipose | 1.12294568 |
| 42 | MP0001661_extended_life_span | 1.10256630 |
| 43 | MP0002108_abnormal_muscle_morphology | 1.09454316 |
| 44 | MP0005165_increased_susceptibility_to | 1.08439005 |
| 45 | MP0000266_abnormal_heart_morphology | 1.06203562 |
| 46 | MP0005375_adipose_tissue_phenotype | 1.06143822 |
| 47 | MP0003567_abnormal_fetal_cardiomyocyte | 1.05634715 |
| 48 | MP0005266_abnormal_metabolism | 0.96771262 |
| 49 | MP0002234_abnormal_pharynx_morphology | 0.96493513 |
| 50 | MP0000733_abnormal_muscle_development | 0.90743607 |
| 51 | MP0004043_abnormal_pH_regulation | 0.89428744 |
| 52 | MP0009780_abnormal_chondrocyte_physiolo | 0.87944093 |
| 53 | MP0002971_abnormal_brown_adipose | 0.80973652 |
| 54 | MP0000230_abnormal_systemic_arterial | 0.78848480 |
| 55 | MP0003806_abnormal_nucleotide_metabolis | 0.78169111 |
| 56 | MP0010368_abnormal_lymphatic_system | 0.73799411 |
| 57 | MP0004134_abnormal_chest_morphology | 0.72890642 |
| 58 | MP0000372_irregular_coat_pigmentation | 0.72754563 |
| 59 | MP0004147_increased_porphyrin_level | 0.72322522 |
| 60 | MP0003279_aneurysm | 0.67600940 |
| 61 | MP0004142_abnormal_muscle_tone | 0.66569719 |
| 62 | MP0002128_abnormal_blood_circulation | 0.65479987 |
| 63 | MP0001299_abnormal_eye_distance/ | 0.65164666 |
| 64 | MP0000003_abnormal_adipose_tissue | 0.61557429 |
| 65 | MP0000013_abnormal_adipose_tissue | 0.60450305 |
| 66 | MP0002078_abnormal_glucose_homeostasis | 0.59312904 |
| 67 | MP0003879_abnormal_hair_cell | 0.57530098 |
| 68 | MP0005423_abnormal_somatic_nervous | 0.56171466 |
| 69 | MP0006276_abnormal_autonomic_nervous | 0.55668713 |
| 70 | MP0005319_abnormal_enzyme/_coenzyme | 0.54365075 |
| 71 | MP0002909_abnormal_adrenal_gland | 0.53020356 |
| 72 | MP0003566_abnormal_cell_adhesion | 0.52722344 |
| 73 | MP0001529_abnormal_vocalization | 0.51898057 |
| 74 | MP0001879_abnormal_lymphatic_vessel | 0.51714238 |
| 75 | MP0008569_lethality_at_weaning | 0.49009926 |
| 76 | MP0008961_abnormal_basal_metabolism | 0.48765774 |
| 77 | MP0005623_abnormal_meninges_morphology | 0.47871846 |
| 78 | MP0002638_abnormal_pupillary_reflex | 0.47327471 |
| 79 | MP0003705_abnormal_hypodermis_morpholog | 0.46279612 |
| 80 | MP0002734_abnormal_mechanical_nocicepti | 0.45579927 |
| 81 | MP0003195_calcinosis | 0.45266662 |
| 82 | MP0005187_abnormal_penis_morphology | 0.44911982 |
| 83 | MP0005535_abnormal_body_temperature | 0.44333335 |
| 84 | MP0002822_catalepsy | 0.41875656 |
| 85 | MP0009672_abnormal_birth_weight | 0.39272593 |
| 86 | MP0005334_abnormal_fat_pad | 0.38472123 |
| 87 | MP0000767_abnormal_smooth_muscle | 0.38006414 |
| 88 | MP0002876_abnormal_thyroid_physiology | 0.37900086 |
| 89 | MP0005083_abnormal_biliary_tract | 0.37726601 |
| 90 | MP0005451_abnormal_body_composition | 0.36970675 |
| 91 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.34786493 |
| 92 | MP0002114_abnormal_axial_skeleton | 0.33802112 |
| 93 | MP0009840_abnormal_foam_cell | 0.33443945 |
| 94 | MP0005645_abnormal_hypothalamus_physiol | 0.33330851 |
| 95 | MP0005166_decreased_susceptibility_to | 0.33253032 |
| 96 | MP0002925_abnormal_cardiovascular_devel | 0.32779404 |
| 97 | MP0002118_abnormal_lipid_homeostasis | 0.32427904 |
| 98 | MP0005275_abnormal_skin_tensile | 0.32380900 |
| 99 | MP0001853_heart_inflammation | 0.30085834 |
| 100 | MP0002066_abnormal_motor_capabilities/c | 0.29635383 |
| 101 | MP0003656_abnormal_erythrocyte_physiolo | 0.29490806 |
| 102 | MP0010030_abnormal_orbit_morphology | 0.28608187 |
| 103 | MP0003948_abnormal_gas_homeostasis | 0.28342834 |
| 104 | MP0001346_abnormal_lacrimal_gland | 0.28142972 |
| 105 | MP0001943_abnormal_respiration | 0.26999440 |
| 106 | MP0001614_abnormal_blood_vessel | 0.26743714 |
| 107 | MP0001727_abnormal_embryo_implantation | 0.26638937 |
| 108 | MP0009250_abnormal_appendicular_skeleto | 0.26521271 |
| 109 | MP0002067_abnormal_sensory_capabilities | 0.26437005 |
| 110 | MP0005386_behavior/neurological_phenoty | 0.26269313 |
| 111 | MP0004924_abnormal_behavior | 0.26269313 |
| 112 | MP0001984_abnormal_olfaction | 0.26249983 |
| 113 | MP0009115_abnormal_fat_cell | 0.24464650 |
| 114 | MP0005452_abnormal_adipose_tissue | 0.23767746 |
| 115 | MP0001784_abnormal_fluid_regulation | 0.23635703 |
| 116 | MP0008438_abnormal_cutaneous_collagen | 0.23557810 |
| 117 | MP0005085_abnormal_gallbladder_physiolo | 0.23540849 |
| 118 | MP0002896_abnormal_bone_mineralization | 0.23208593 |
| 119 | MP0005332_abnormal_amino_acid | 0.22755520 |
| 120 | MP0003045_fibrosis | 0.22526913 |
| 121 | MP0003984_embryonic_growth_retardation | 0.21799763 |
| 122 | MP0002877_abnormal_melanocyte_morpholog | 0.21723424 |
| 123 | MP0004272_abnormal_basement_membrane | 0.21334751 |
| 124 | MP0003959_abnormal_lean_body | 0.21165682 |
| 125 | MP0005376_homeostasis/metabolism_phenot | 0.21006858 |
| 126 | MP0002088_abnormal_embryonic_growth/wei | 0.20822313 |
| 127 | MP0000249_abnormal_blood_vessel | 0.20654844 |
| 128 | MP0005167_abnormal_blood-brain_barrier | 0.18923659 |
| 129 | MP0000762_abnormal_tongue_morphology | 0.16228968 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Exercise-induced myalgia (HP:0003738) | 6.90928779 |
| 2 | Calf muscle hypertrophy (HP:0008981) | 6.72207765 |
| 3 | Exercise-induced muscle cramps (HP:0003710) | 6.70228718 |
| 4 | Sudden death (HP:0001699) | 6.70055655 |
| 5 | Muscle hypertrophy of the lower extremities (HP:0008968) | 6.57569075 |
| 6 | Ventricular tachycardia (HP:0004756) | 5.93053790 |
| 7 | Muscle fiber splitting (HP:0003555) | 5.62778312 |
| 8 | Myoglobinuria (HP:0002913) | 5.55574176 |
| 9 | Abnormality of the calf musculature (HP:0001430) | 5.18075806 |
| 10 | Hyporeflexia of lower limbs (HP:0002600) | 5.04895311 |
| 11 | Atrial fibrillation (HP:0005110) | 5.02200108 |
| 12 | Muscle fiber inclusion bodies (HP:0100299) | 4.90882591 |
| 13 | Primary atrial arrhythmia (HP:0001692) | 4.69372455 |
| 14 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 4.66679530 |
| 15 | Supraventricular tachycardia (HP:0004755) | 4.53217939 |
| 16 | Lipoatrophy (HP:0100578) | 4.43354210 |
| 17 | Supraventricular arrhythmia (HP:0005115) | 4.42361511 |
| 18 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 4.40738703 |
| 19 | EMG: myopathic abnormalities (HP:0003458) | 4.38691125 |
| 20 | Subaortic stenosis (HP:0001682) | 4.37508111 |
| 21 | Abnormality of the left ventricular outflow tract (HP:0011103) | 4.37508111 |
| 22 | Rhabdomyolysis (HP:0003201) | 4.33323016 |
| 23 | Difficulty running (HP:0009046) | 4.28589785 |
| 24 | Bundle branch block (HP:0011710) | 4.20846662 |
| 25 | Right ventricular cardiomyopathy (HP:0011663) | 4.17078517 |
| 26 | Nemaline bodies (HP:0003798) | 4.07877809 |
| 27 | Syncope (HP:0001279) | 4.06581278 |
| 28 | Increased connective tissue (HP:0009025) | 4.03310380 |
| 29 | Calcaneovalgus deformity (HP:0001848) | 4.00608487 |
| 30 | Palpitations (HP:0001962) | 3.97341003 |
| 31 | Asymmetric septal hypertrophy (HP:0001670) | 3.95185132 |
| 32 | Dilated cardiomyopathy (HP:0001644) | 3.84104748 |
| 33 | Type 1 muscle fiber predominance (HP:0003803) | 3.69452293 |
| 34 | Myotonia (HP:0002486) | 3.69164991 |
| 35 | Absent phalangeal crease (HP:0006109) | 3.63291795 |
| 36 | Prolonged QT interval (HP:0001657) | 3.59675780 |
| 37 | Deformed tarsal bones (HP:0008119) | 3.54989648 |
| 38 | Heart block (HP:0012722) | 3.44067447 |
| 39 | Ventricular arrhythmia (HP:0004308) | 3.41430634 |
| 40 | Muscle stiffness (HP:0003552) | 3.38786136 |
| 41 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.27120766 |
| 42 | Abnormal atrioventricular conduction (HP:0005150) | 3.24846922 |
| 43 | Acute necrotizing encephalopathy (HP:0006965) | 3.24807969 |
| 44 | Malignant hyperthermia (HP:0002047) | 3.19983624 |
| 45 | Difficulty climbing stairs (HP:0003551) | 3.07494587 |
| 46 | Atrioventricular block (HP:0001678) | 3.06823514 |
| 47 | Abnormal finger flexion creases (HP:0006143) | 3.03153595 |
| 48 | Hepatic necrosis (HP:0002605) | 3.02495424 |
| 49 | Ventricular fibrillation (HP:0001663) | 2.88726874 |
| 50 | Areflexia of lower limbs (HP:0002522) | 2.85617318 |
| 51 | Acute encephalopathy (HP:0006846) | 2.82525815 |
| 52 | Distal lower limb muscle weakness (HP:0009053) | 2.81696681 |
| 53 | Increased variability in muscle fiber diameter (HP:0003557) | 2.81530692 |
| 54 | Abnormality of skeletal muscle fiber size (HP:0012084) | 2.80053539 |
| 55 | Ketoacidosis (HP:0001993) | 2.75383584 |
| 56 | Progressive macrocephaly (HP:0004481) | 2.73395705 |
| 57 | Distal arthrogryposis (HP:0005684) | 2.71178084 |
| 58 | Mildly elevated creatine phosphokinase (HP:0008180) | 2.69559943 |
| 59 | Neck muscle weakness (HP:0000467) | 2.67016396 |
| 60 | Fetal akinesia sequence (HP:0001989) | 2.63282883 |
| 61 | Left ventricular hypertrophy (HP:0001712) | 2.60599907 |
| 62 | Hypoglycemic coma (HP:0001325) | 2.60485203 |
| 63 | Hepatocellular necrosis (HP:0001404) | 2.60259338 |
| 64 | Myopathic facies (HP:0002058) | 2.59665232 |
| 65 | Abnormal EKG (HP:0003115) | 2.57300217 |
| 66 | Bulbar palsy (HP:0001283) | 2.55038207 |
| 67 | Rimmed vacuoles (HP:0003805) | 2.53880600 |
| 68 | Cerebral edema (HP:0002181) | 2.53778863 |
| 69 | Abnormality of alanine metabolism (HP:0010916) | 2.52940144 |
| 70 | Hyperalaninemia (HP:0003348) | 2.52940144 |
| 71 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.52940144 |
| 72 | Weak cry (HP:0001612) | 2.52609179 |
| 73 | Slender build (HP:0001533) | 2.51591267 |
| 74 | Mitochondrial inheritance (HP:0001427) | 2.51304283 |
| 75 | Increased muscle lipid content (HP:0009058) | 2.43825529 |
| 76 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.41510845 |
| 77 | Dicarboxylic aciduria (HP:0003215) | 2.41510845 |
| 78 | Increased CSF lactate (HP:0002490) | 2.40411695 |
| 79 | Abnormality of fatty-acid metabolism (HP:0004359) | 2.40248079 |
| 80 | Limb-girdle muscle atrophy (HP:0003797) | 2.38324921 |
| 81 | Exercise intolerance (HP:0003546) | 2.35504683 |
| 82 | Hyperkalemia (HP:0002153) | 2.33010903 |
| 83 | Hypoplastic ischia (HP:0003175) | 2.32822698 |
| 84 | Abnormality of the calcaneus (HP:0008364) | 2.31614983 |
| 85 | Abnormality of the neuromuscular junction (HP:0003398) | 2.30938820 |
| 86 | Fatigable weakness (HP:0003473) | 2.30938820 |
| 87 | Round ear (HP:0100830) | 2.29691137 |
| 88 | Conjunctival hamartoma (HP:0100780) | 2.28127835 |
| 89 | Facial diplegia (HP:0001349) | 2.21544302 |
| 90 | Lactic acidosis (HP:0003128) | 2.20528809 |
| 91 | Palmoplantar keratoderma (HP:0000982) | 2.19714500 |
| 92 | Increased intramyocellular lipid droplets (HP:0012240) | 2.17958493 |
| 93 | Gowers sign (HP:0003391) | 2.12436068 |
| 94 | Spinal rigidity (HP:0003306) | 2.12082153 |
| 95 | Muscular dystrophy (HP:0003560) | 2.11137113 |
| 96 | Respiratory failure (HP:0002878) | 2.09619385 |
| 97 | Hip contracture (HP:0003273) | 2.07919535 |
| 98 | Distal lower limb amyotrophy (HP:0008944) | 2.07701184 |
| 99 | Waddling gait (HP:0002515) | 2.05604096 |
| 100 | Pheochromocytoma (HP:0002666) | 2.04873463 |
| 101 | Testicular atrophy (HP:0000029) | 2.03720224 |
| 102 | Ketosis (HP:0001946) | 2.03363184 |
| 103 | Progressive muscle weakness (HP:0003323) | 2.03277936 |
| 104 | Abnormality of the ischium (HP:0003174) | 2.02475076 |
| 105 | EMG: neuropathic changes (HP:0003445) | 1.98431563 |
| 106 | Ulnar deviation of the wrist (HP:0003049) | 1.96818367 |
| 107 | Generalized muscle weakness (HP:0003324) | 1.96624431 |
| 108 | Ragged-red muscle fibers (HP:0003200) | 1.92799465 |
| 109 | Proximal amyotrophy (HP:0007126) | 1.92757828 |
| 110 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 1.92519367 |
| 111 | Abnormality of the shoulder girdle musculature (HP:0001435) | 1.90829295 |
| 112 | Respiratory insufficiency due to muscle weakness (HP:0002747) | 1.90465747 |
| 113 | Lower limb amyotrophy (HP:0007210) | 1.89695696 |
| 114 | Abnormality of the foot musculature (HP:0001436) | 1.89160962 |
| 115 | Frequent falls (HP:0002359) | 1.88932865 |
| 116 | Long clavicles (HP:0000890) | 1.85412996 |
| 117 | Shoulder girdle muscle weakness (HP:0003547) | 1.85121536 |
| 118 | Abnormality of glycolysis (HP:0004366) | 1.85106911 |
| 119 | Increased serum pyruvate (HP:0003542) | 1.85106911 |
| 120 | Abnormality of the hip-girdle musculature (HP:0001445) | 1.85029797 |
| 121 | Abnormality of the musculature of the pelvis (HP:0001469) | 1.85029797 |
| 122 | Neuroendocrine neoplasm (HP:0100634) | 1.84410261 |
| 123 | Esophageal neoplasm (HP:0100751) | 1.83432519 |
| 124 | Neoplasm of head and neck (HP:0012288) | 1.83432519 |
| 125 | Central scotoma (HP:0000603) | 1.81158330 |
| 126 | Scapular winging (HP:0003691) | 1.80908570 |
| 127 | Paralysis (HP:0003470) | 1.76169558 |
| 128 | Pelvic girdle muscle weakness (HP:0003749) | 1.75573395 |
| 129 | Foot dorsiflexor weakness (HP:0009027) | 1.70771926 |
| 130 | Type 2 muscle fiber atrophy (HP:0003554) | 1.65286648 |
| 131 | Popliteal pterygium (HP:0009756) | 1.63646161 |
| 132 | Limb-girdle muscle weakness (HP:0003325) | 1.63393639 |
| 133 | Nonprogressive disorder (HP:0003680) | 1.62423718 |
| 134 | Muscle fiber atrophy (HP:0100295) | 1.53247197 |
| 135 | Ulnar deviation of finger (HP:0009465) | 1.51065240 |
| 136 | Metatarsus adductus (HP:0001840) | 1.50160408 |
| 137 | Insulin-resistant diabetes mellitus (HP:0000831) | 1.47619552 |
| 138 | Oligomenorrhea (HP:0000876) | 1.46977320 |
| 139 | Limited hip movement (HP:0008800) | 1.38538364 |
| 140 | Steppage gait (HP:0003376) | 1.36264492 |
| 141 | Ulnar deviation of the hand or of fingers of the hand (HP:0001193) | 1.29807743 |
| 142 | Abnormality of placental membranes (HP:0011409) | 1.22416533 |
| 143 | Amniotic constriction ring (HP:0009775) | 1.22416533 |
| 144 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 1.21050462 |
| 145 | Congenital hip dislocation (HP:0001374) | 1.20278190 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TTN | 6.65077941 |
| 2 | OBSCN | 5.69225691 |
| 3 | PHKG2 | 4.50530101 |
| 4 | PHKG1 | 4.50530101 |
| 5 | PDK4 | 3.86566576 |
| 6 | PDK3 | 3.86566576 |
| 7 | LMTK2 | 3.01297061 |
| 8 | DMPK | 2.73038994 |
| 9 | PKN2 | 2.64712664 |
| 10 | MYLK | 2.63326852 |
| 11 | BCKDK | 2.51692361 |
| 12 | PINK1 | 2.49202921 |
| 13 | PDK2 | 2.42857308 |
| 14 | NEK1 | 2.37108985 |
| 15 | TRIB3 | 2.30326495 |
| 16 | MUSK | 2.08078329 |
| 17 | PIK3CA | 2.01490516 |
| 18 | STK24 | 1.79500929 |
| 19 | GRK7 | 1.62405045 |
| 20 | TIE1 | 1.60824296 |
| 21 | MAP2K3 | 1.43660977 |
| 22 | MAP3K7 | 1.37804280 |
| 23 | MARK1 | 1.29124681 |
| 24 | ERBB3 | 1.28344001 |
| 25 | MAPK12 | 1.19552210 |
| 26 | PIK3CG | 1.18501084 |
| 27 | NME1 | 1.17372454 |
| 28 | CCNB1 | 1.13006504 |
| 29 | CAMK2D | 1.11529867 |
| 30 | PRKD1 | 1.03676089 |
| 31 | PAK3 | 1.03348903 |
| 32 | LIMK1 | 1.00519746 |
| 33 | ILK | 0.91950558 |
| 34 | PRKAA1 | 0.91264904 |
| 35 | TRPM7 | 0.90491131 |
| 36 | PRKAA2 | 0.87734699 |
| 37 | DYRK1B | 0.83161204 |
| 38 | NME2 | 0.81890596 |
| 39 | CDK19 | 0.80490606 |
| 40 | WNK4 | 0.79614339 |
| 41 | FLT3 | 0.79480685 |
| 42 | ZAK | 0.78854235 |
| 43 | NEK9 | 0.77936113 |
| 44 | INSRR | 0.77889286 |
| 45 | MOS | 0.74905079 |
| 46 | ROCK1 | 0.71767744 |
| 47 | MAP3K3 | 0.69269606 |
| 48 | CAMK4 | 0.68652926 |
| 49 | MAPKAPK3 | 0.68407097 |
| 50 | STK4 | 0.68121535 |
| 51 | PKN1 | 0.68029326 |
| 52 | EEF2K | 0.67900053 |
| 53 | STK38L | 0.65801972 |
| 54 | MAP3K5 | 0.63959683 |
| 55 | MAP2K4 | 0.58529008 |
| 56 | RIPK1 | 0.56222712 |
| 57 | CDC42BPA | 0.56034675 |
| 58 | CAMK2A | 0.52927717 |
| 59 | WNK1 | 0.52438461 |
| 60 | STK38 | 0.48427413 |
| 61 | CAMK2G | 0.47913109 |
| 62 | MAPK13 | 0.47613630 |
| 63 | EPHB1 | 0.47428076 |
| 64 | PDGFRA | 0.45996558 |
| 65 | MAPK4 | 0.44894245 |
| 66 | PRKACB | 0.44599606 |
| 67 | MAP4K2 | 0.44170479 |
| 68 | STK39 | 0.43164250 |
| 69 | CAMK2B | 0.42416354 |
| 70 | TGFBR2 | 0.42407614 |
| 71 | CAMK1 | 0.41995628 |
| 72 | MAP2K6 | 0.41827913 |
| 73 | MAP3K13 | 0.40776750 |
| 74 | ROCK2 | 0.40283693 |
| 75 | SGK2 | 0.40138007 |
| 76 | DAPK3 | 0.39949792 |
| 77 | AKT2 | 0.39595620 |
| 78 | MAP2K1 | 0.36898303 |
| 79 | PDPK1 | 0.36725014 |
| 80 | KDR | 0.36695072 |
| 81 | PRKACA | 0.36596579 |
| 82 | TBK1 | 0.36238132 |
| 83 | PDK1 | 0.35376783 |
| 84 | PRKACG | 0.33806154 |
| 85 | RPS6KL1 | 0.33579582 |
| 86 | RPS6KC1 | 0.33579582 |
| 87 | TAOK3 | 0.30607915 |
| 88 | DAPK2 | 0.28175758 |
| 89 | RPS6KA6 | 0.26556995 |
| 90 | MAP3K11 | 0.26201661 |
| 91 | PTK2B | 0.26010663 |
| 92 | RPS6KB1 | 0.24724261 |
| 93 | PTK6 | 0.24052686 |
| 94 | MAPK11 | 0.23979006 |
| 95 | PRKCE | 0.22515809 |
| 96 | RPS6KA1 | 0.21902966 |
| 97 | SGK1 | 0.21116249 |
| 98 | ICK | 0.20376982 |
| 99 | SGK494 | 0.20239070 |
| 100 | SGK223 | 0.20239070 |
| 101 | MAPK10 | 0.19499368 |
| 102 | SIK1 | 0.19300481 |
| 103 | MAP3K1 | 0.19058939 |
| 104 | RET | 0.18367090 |
| 105 | PRKCH | 0.17709275 |
| 106 | TAOK1 | 0.17533824 |
| 107 | PRKG1 | 0.17525144 |
| 108 | JAK1 | 0.16249285 |
| 109 | RPS6KA3 | 0.15629618 |
| 110 | TAOK2 | 0.15004716 |
| 111 | MAPK7 | 0.14467019 |
| 112 | SGK3 | 0.13432372 |
| 113 | LATS2 | 0.11921182 |
| 114 | PRKG2 | 0.11545492 |
| 115 | JAK2 | 0.09626466 |
| 116 | PAK6 | 0.09304659 |
| 117 | LRRK2 | 0.09053489 |
| 118 | LATS1 | 0.08875106 |
| 119 | STK11 | 0.08796010 |
| 120 | FGFR4 | 0.08048932 |
| 121 | OXSR1 | 0.08046290 |
| 122 | MTOR | 0.07931757 |
| 123 | CSNK1D | 0.07433325 |
| 124 | MARK2 | 0.07250240 |
| 125 | PRKCQ | 0.06376395 |
| 126 | KSR2 | 0.05973533 |
| 127 | EPHA3 | 0.05650585 |
| 128 | FER | 0.05508485 |
| 129 | RPS6KB2 | 0.04688916 |
| 130 | BMPR1B | 0.04579501 |
| 131 | CDK5 | 0.03603307 |
| 132 | MAPK9 | 0.02950421 |
| 133 | GSK3B | 0.02616841 |
| 134 | ZAP70 | 0.02431981 |
| 135 | MAPK3 | 0.02273800 |
| 136 | MARK3 | 0.01880143 |
| 137 | PRKDC | 0.01407373 |
| 138 | MAPK8 | 0.01274101 |
| 139 | BRAF | 0.00858264 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 6.03770868 |
| 2 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 4.22359755 |
| 3 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 4.04411853 |
| 4 | Propanoate metabolism_Homo sapiens_hsa00640 | 3.52749824 |
| 5 | Parkinsons disease_Homo sapiens_hsa05012 | 3.38316907 |
| 6 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 3.36508353 |
| 7 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 3.35799873 |
| 8 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.32262889 |
| 9 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 3.18276126 |
| 10 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.95401366 |
| 11 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.59253353 |
| 12 | Alzheimers disease_Homo sapiens_hsa05010 | 2.56232773 |
| 13 | Carbon metabolism_Homo sapiens_hsa01200 | 2.55440086 |
| 14 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 2.48262158 |
| 15 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.37234611 |
| 16 | Fatty acid metabolism_Homo sapiens_hsa01212 | 2.24649901 |
| 17 | Huntingtons disease_Homo sapiens_hsa05016 | 2.08354864 |
| 18 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.87393347 |
| 19 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.57276355 |
| 20 | Viral myocarditis_Homo sapiens_hsa05416 | 1.53175461 |
| 21 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.52265224 |
| 22 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.50865254 |
| 23 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.41926831 |
| 24 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.36163947 |
| 25 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.35772076 |
| 26 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.26466753 |
| 27 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.18423810 |
| 28 | Insulin resistance_Homo sapiens_hsa04931 | 1.15682625 |
| 29 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.10404954 |
| 30 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 1.09414252 |
| 31 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 1.05688630 |
| 32 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.02554766 |
| 33 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.99912513 |
| 34 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.93080943 |
| 35 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.90210213 |
| 36 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.85988801 |
| 37 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.83472871 |
| 38 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.82618707 |
| 39 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.82131085 |
| 40 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.77541491 |
| 41 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.77347526 |
| 42 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.77043866 |
| 43 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.76712897 |
| 44 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.71924261 |
| 45 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.70304829 |
| 46 | Long-term potentiation_Homo sapiens_hsa04720 | 0.69793487 |
| 47 | Lysine degradation_Homo sapiens_hsa00310 | 0.65500653 |
| 48 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.65289292 |
| 49 | Galactose metabolism_Homo sapiens_hsa00052 | 0.65036104 |
| 50 | Peroxisome_Homo sapiens_hsa04146 | 0.63544774 |
| 51 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.58622222 |
| 52 | Focal adhesion_Homo sapiens_hsa04510 | 0.57402705 |
| 53 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.55258669 |
| 54 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.52900308 |
| 55 | Circadian rhythm_Homo sapiens_hsa04710 | 0.52050689 |
| 56 | Salivary secretion_Homo sapiens_hsa04970 | 0.51215756 |
| 57 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.50268581 |
| 58 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.50182083 |
| 59 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.49152406 |
| 60 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.46381685 |
| 61 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.45413021 |
| 62 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.44439063 |
| 63 | Long-term depression_Homo sapiens_hsa04730 | 0.44081514 |
| 64 | Tight junction_Homo sapiens_hsa04530 | 0.41582672 |
| 65 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.40513082 |
| 66 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.38542340 |
| 67 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.38042075 |
| 68 | Purine metabolism_Homo sapiens_hsa00230 | 0.37572374 |
| 69 | Renin secretion_Homo sapiens_hsa04924 | 0.36639762 |
| 70 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.33385898 |
| 71 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.32999116 |
| 72 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.31779409 |
| 73 | Metabolic pathways_Homo sapiens_hsa01100 | 0.30834303 |
| 74 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.30031233 |
| 75 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.28292694 |
| 76 | Insulin secretion_Homo sapiens_hsa04911 | 0.27687152 |
| 77 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.22954947 |
| 78 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.21944656 |
| 79 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.21629686 |
| 80 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.20812744 |
| 81 | Histidine metabolism_Homo sapiens_hsa00340 | 0.20419134 |
| 82 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.18464958 |
| 83 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.16897526 |
| 84 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.16091516 |
| 85 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.15769547 |
| 86 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.15169632 |
| 87 | Adherens junction_Homo sapiens_hsa04520 | 0.15122695 |
| 88 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.14766799 |
| 89 | Amoebiasis_Homo sapiens_hsa05146 | 0.14732539 |
| 90 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.14179370 |
| 91 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.14115477 |
| 92 | Platelet activation_Homo sapiens_hsa04611 | 0.13898680 |
| 93 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.13771933 |
| 94 | Olfactory transduction_Homo sapiens_hsa04740 | 0.13518503 |
| 95 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.13040476 |
| 96 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.12552047 |
| 97 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.12506109 |
| 98 | Sulfur relay system_Homo sapiens_hsa04122 | 0.12211773 |
| 99 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.12185182 |
| 100 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.11215385 |
| 101 | Phototransduction_Homo sapiens_hsa04744 | 0.10947033 |
| 102 | Circadian entrainment_Homo sapiens_hsa04713 | 0.09883287 |
| 103 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.09597434 |
| 104 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.09334105 |
| 105 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.08889393 |
| 106 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.08861021 |
| 107 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.08749507 |
| 108 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.07444669 |
| 109 | Glioma_Homo sapiens_hsa05214 | 0.05394535 |
| 110 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.05004737 |
| 111 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.04597134 |
| 112 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.04227351 |
| 113 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.03726243 |
| 114 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.03697033 |
| 115 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.03155119 |
| 116 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.03057311 |
| 117 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.02245525 |
| 118 | Gap junction_Homo sapiens_hsa04540 | 0.00994470 |
| 119 | GABAergic synapse_Homo sapiens_hsa04727 | 0.00832134 |
| 120 | Bile secretion_Homo sapiens_hsa04976 | 0.00521817 |
| 121 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | -0.0278315 |
| 122 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | -0.0278173 |
| 123 | ABC transporters_Homo sapiens_hsa02010 | -0.0156572 |
| 124 | Toxoplasmosis_Homo sapiens_hsa05145 | -0.0029260 |

