YJEFN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)6.29289755
2vocalization behavior (GO:0071625)5.66752188
3positive regulation of synapse maturation (GO:0090129)5.56718527
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.25413360
5protein localization to synapse (GO:0035418)4.78704957
6cerebellar granule cell differentiation (GO:0021707)4.73744325
7cell migration in hindbrain (GO:0021535)4.62332102
8neuron cell-cell adhesion (GO:0007158)4.54508258
9locomotory exploration behavior (GO:0035641)4.52482666
10neuronal ion channel clustering (GO:0045161)4.49149344
11ATP hydrolysis coupled proton transport (GO:0015991)4.45629860
12energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.45629860
13glutamate secretion (GO:0014047)4.40023950
14neurotransmitter-gated ion channel clustering (GO:0072578)4.32403122
15synaptic vesicle maturation (GO:0016188)4.32365361
16regulation of glutamate receptor signaling pathway (GO:1900449)4.28482504
17regulation of synapse maturation (GO:0090128)4.25079984
18postsynaptic membrane organization (GO:0001941)4.24897267
19regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.22746402
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.15774819
21neurotransmitter secretion (GO:0007269)4.14131364
22positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.02472939
23positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.98386122
24establishment of mitochondrion localization (GO:0051654)3.98366570
25cellular potassium ion homeostasis (GO:0030007)3.97941726
26cerebellar Purkinje cell differentiation (GO:0021702)3.96381261
27dendritic spine organization (GO:0097061)3.90178684
28positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.89555271
29positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.88710041
30cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.86028902
31dendritic spine morphogenesis (GO:0060997)3.86008263
32sodium ion export (GO:0071436)3.84828846
33cell communication by electrical coupling (GO:0010644)3.83400797
34neuromuscular process controlling balance (GO:0050885)3.81253331
35positive regulation of dendritic spine development (GO:0060999)3.79461142
36regulation of synaptic vesicle exocytosis (GO:2000300)3.78687244
37regulation of synapse structural plasticity (GO:0051823)3.76961038
38exploration behavior (GO:0035640)3.72865001
39cellular sodium ion homeostasis (GO:0006883)3.71536201
40positive regulation of dendritic spine morphogenesis (GO:0061003)3.70005649
41ionotropic glutamate receptor signaling pathway (GO:0035235)3.66094424
42glutamate receptor signaling pathway (GO:0007215)3.65308864
43regulation of neurotransmitter secretion (GO:0046928)3.64353394
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.57861184
45mitochondrion transport along microtubule (GO:0047497)3.54484889
46establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.54484889
47mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.54376186
48neuromuscular synaptic transmission (GO:0007274)3.52957555
49regulation of synaptic vesicle transport (GO:1902803)3.52476256
50regulation of neuronal synaptic plasticity (GO:0048168)3.52406103
51succinate metabolic process (GO:0006105)3.52276433
52neuronal action potential propagation (GO:0019227)3.51976418
53regulation of long-term neuronal synaptic plasticity (GO:0048169)3.48501666
54regulation of ARF protein signal transduction (GO:0032012)3.48121515
55synaptic transmission, glutamatergic (GO:0035249)3.46776830
56neuron-neuron synaptic transmission (GO:0007270)3.38975465
57startle response (GO:0001964)3.37890672
58gamma-aminobutyric acid transport (GO:0015812)3.37844284
59regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.36731124
60amino acid import (GO:0043090)3.35572199
61regulation of synaptic plasticity (GO:0048167)3.33780251
62G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.32539551
63chemosensory behavior (GO:0007635)3.32452853
64gamma-aminobutyric acid signaling pathway (GO:0007214)3.31217798
65positive regulation of neurotransmitter transport (GO:0051590)3.30453781
66transferrin transport (GO:0033572)3.29211300
67positive regulation of potassium ion transmembrane transport (GO:1901381)3.25689212
68activation of protein kinase A activity (GO:0034199)3.25454078
69proline transport (GO:0015824)3.25363779
70cell differentiation in hindbrain (GO:0021533)3.24422254
71synaptic vesicle docking involved in exocytosis (GO:0016081)3.23259479
72long-term synaptic potentiation (GO:0060291)3.19390634
73detection of calcium ion (GO:0005513)3.18031058
74neurotransmitter transport (GO:0006836)3.17485212
75membrane repolarization (GO:0086009)3.16675560
76regulation of cofactor metabolic process (GO:0051193)3.16503761
77regulation of coenzyme metabolic process (GO:0051196)3.16503761
78calcium ion-dependent exocytosis (GO:0017156)3.15081597
79regulation of neurotransmitter transport (GO:0051588)3.13128939
80regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.12976226
81cerebellar Purkinje cell layer development (GO:0021680)3.12643350
82regulation of vesicle fusion (GO:0031338)3.12595002
83regulation of excitatory postsynaptic membrane potential (GO:0060079)3.10336879
84positive regulation of neurotransmitter secretion (GO:0001956)3.08502885
85regulation of membrane repolarization (GO:0060306)3.08469548
86long-term memory (GO:0007616)3.08331674
87L-amino acid import (GO:0043092)3.08284496
88regulation of voltage-gated calcium channel activity (GO:1901385)3.07355893
89G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.05889401
90trivalent inorganic cation transport (GO:0072512)3.04405208
91ferric iron transport (GO:0015682)3.04405208
92energy coupled proton transport, down electrochemical gradient (GO:0015985)3.03227226
93ATP synthesis coupled proton transport (GO:0015986)3.03227226
94regulation of cell communication by electrical coupling (GO:0010649)3.03044179
95regulation of neurotransmitter levels (GO:0001505)3.02881852
96cytoskeletal anchoring at plasma membrane (GO:0007016)3.01681640
97regulation of glutamate secretion (GO:0014048)2.99902104
98layer formation in cerebral cortex (GO:0021819)2.98551993
99behavioral fear response (GO:0001662)2.96874949
100behavioral defense response (GO:0002209)2.96874949
101neuromuscular process (GO:0050905)2.96840465
102regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.96171043
103regulation of ARF GTPase activity (GO:0032312)2.95539396
104axonal fasciculation (GO:0007413)2.95360719
105membrane depolarization (GO:0051899)2.94562826
106negative regulation of amino acid transport (GO:0051956)2.94224644
107regulation of synaptic transmission, glutamatergic (GO:0051966)2.93742338
108regulation of dendrite morphogenesis (GO:0048814)2.93512569
109positive regulation of synapse assembly (GO:0051965)2.92127289
110regulation of dendritic spine morphogenesis (GO:0061001)2.90779002
111regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.90766674
112behavioral response to cocaine (GO:0048148)2.90578924
113neuron recognition (GO:0008038)2.89027575
114membrane depolarization during action potential (GO:0086010)2.87390784
115learning (GO:0007612)2.85445036
116regulation of postsynaptic membrane potential (GO:0060078)2.84257717
117negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.83377787
118positive regulation of dendrite development (GO:1900006)2.83356629
119striatum development (GO:0021756)2.82252739
120negative regulation of dendrite morphogenesis (GO:0050774)2.81626107
121axon ensheathment in central nervous system (GO:0032291)2.80880350
122central nervous system myelination (GO:0022010)2.80880350
123synaptic vesicle endocytosis (GO:0048488)2.80716584
124potassium ion homeostasis (GO:0055075)2.79658567
125positive regulation of membrane potential (GO:0045838)2.79532801
126sarcoplasmic reticulum calcium ion transport (GO:0070296)2.79131264
127positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.79079848
128neuromuscular process controlling posture (GO:0050884)2.78913020
129regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.78885952
130calcium-mediated signaling using intracellular calcium source (GO:0035584)2.78115985
131mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.77967047
132transmission of nerve impulse (GO:0019226)2.77587024
133tricarboxylic acid cycle (GO:0006099)2.77567696
134long term synaptic depression (GO:0060292)2.76151323
135negative regulation of synaptic transmission, GABAergic (GO:0032229)2.73097973
136synaptic vesicle transport (GO:0048489)2.71996926
137establishment of synaptic vesicle localization (GO:0097480)2.71996926
138regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.71563945
139fear response (GO:0042596)2.71539923
140regulation of synaptic transmission (GO:0050804)2.70438146
141regulation of calcium ion transmembrane transport (GO:1903169)2.69959850
142regulation of calcium ion transmembrane transporter activity (GO:1901019)2.69959850

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human8.43135436
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.23163557
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.22087145
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.98798560
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.91598553
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.87580295
7REST_21632747_ChIP-Seq_MESCs_Mouse2.80135204
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.77081151
9ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.74332941
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.74024867
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.66311254
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.65564581
13GBX2_23144817_ChIP-Seq_PC3_Human2.63442811
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57002893
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57002893
16REST_18959480_ChIP-ChIP_MESCs_Mouse2.53840348
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.52393580
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.52077261
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.43037726
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.39074695
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.28228321
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.26908733
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.17116210
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.16043503
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.08190596
26DROSHA_22980978_ChIP-Seq_HELA_Human2.05599204
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.98258096
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.94260147
29ZNF263_19887448_ChIP-Seq_K562_Human1.88867559
30* P68_20966046_ChIP-Seq_HELA_Human1.87183500
31SMC4_20622854_ChIP-Seq_HELA_Human1.85050673
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.84947966
33ZFP281_27345836_Chip-Seq_ESCs_Mouse1.72594504
34KDM2B_26808549_Chip-Seq_DND41_Human1.71695426
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64462252
36SRY_22984422_ChIP-ChIP_TESTIS_Rat1.61093154
37AR_21572438_ChIP-Seq_LNCaP_Human1.60414121
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57744031
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.50925585
40* CREB1_26743006_Chip-Seq_LNCaP_Human1.49347646
41TET1_21451524_ChIP-Seq_MESCs_Mouse1.48313082
42ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46470888
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.46351771
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45317783
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43307149
46RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.41271783
47RING1B_27294783_Chip-Seq_ESCs_Mouse1.40208467
48DNAJC2_21179169_ChIP-ChIP_NT2_Human1.40018079
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38682261
50ZNF274_21170338_ChIP-Seq_K562_Hela1.36065992
51OCT4_19829295_ChIP-Seq_ESCs_Human1.34891323
52EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.34539343
53KDM2B_26808549_Chip-Seq_JURKAT_Human1.34385788
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33521276
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28938398
56GATA1_26923725_Chip-Seq_HPCs_Mouse1.27380849
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27360141
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25073480
59* ELF1_20517297_ChIP-Seq_JURKAT_Human1.24442562
60CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23389081
61TCF7_22412390_ChIP-Seq_EML_Mouse1.22363965
62* SA1_27219007_Chip-Seq_ERYTHROID_Human1.21761121
63SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21507111
64UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20276597
65SMAD4_21799915_ChIP-Seq_A2780_Human1.20036406
66* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16487376
67* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.15136936
68KDM2B_26808549_Chip-Seq_K562_Human1.14589170
69SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14055358
70TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.13750506
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13209170
72RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13106913
73WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12848737
74SOX2_21211035_ChIP-Seq_LN229_Gbm1.12839996
75AR_25329375_ChIP-Seq_VCAP_Human1.11699610
76* PHF8_20622854_ChIP-Seq_HELA_Human1.09742792
77CTCF_27219007_Chip-Seq_Bcells_Human1.09544716
78TP53_20018659_ChIP-ChIP_R1E_Mouse1.08474919
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08448491
80CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07181795
81RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06839843
82VDR_21846776_ChIP-Seq_THP-1_Human1.06617392
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06486301
84SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05961778
85EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.05463718
86* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04850291
87* SA1_27219007_Chip-Seq_Bcells_Human1.02531262
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01974746
89SMAD3_21741376_ChIP-Seq_EPCs_Human1.01949458
90RACK7_27058665_Chip-Seq_MCF-7_Human1.01146087
91BCOR_27268052_Chip-Seq_Bcells_Human1.01113616
92DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99925489
93KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99460179
94CBX2_27304074_Chip-Seq_ESCs_Mouse0.99414274
95LXR_22292898_ChIP-Seq_THP-1_Human0.98489207
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98206213
97* BCL6_27268052_Chip-Seq_Bcells_Human0.97047402
98* E2F1_20622854_ChIP-Seq_HELA_Human0.96328007
99ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96137547
100CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95281949
101AR_19668381_ChIP-Seq_PC3_Human0.95245844
102PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94859293
103KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93868813
104RARA_24833708_ChIP-Seq_LIVER_Mouse0.92504956
105CTCF_20526341_ChIP-Seq_ESCs_Human0.92254588
106NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90839471
107WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90738527
108MYC_22102868_ChIP-Seq_BL_Human0.90480921
109NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.90462809
110TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.90432917
111ELK3_25401928_ChIP-Seq_HUVEC_Human0.90367913
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89684494
113RING1B_27294783_Chip-Seq_NPCs_Mouse0.89523346
114JUN_21703547_ChIP-Seq_K562_Human0.89429967
115FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88634133
116EP300_21415370_ChIP-Seq_HL-1_Mouse0.88078464
117P300_19829295_ChIP-Seq_ESCs_Human0.88007961
118TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88000270
119MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.86919583
120YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86151551
121BMI1_23680149_ChIP-Seq_NPCS_Mouse0.85905952
122SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85490480
123TET1_21490601_ChIP-Seq_MESCs_Mouse0.83956994
124PIAS1_25552417_ChIP-Seq_VCAP_Human0.81910459
125TRIM28_21343339_ChIP-Seq_HEK293_Human0.81825594
126SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.81774599
127SMAD3_21741376_ChIP-Seq_ESCs_Human0.81406016
128TAF15_26573619_Chip-Seq_HEK293_Human0.81099416
129MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80198971
130AHR_22903824_ChIP-Seq_MCF-7_Human0.79661452
131SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.73958880
132SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73479767
133* KLF4_19829295_ChIP-Seq_ESCs_Human0.73440667
134IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.73075063
135CBP_20019798_ChIP-Seq_JUKART_Human0.73075063
136ARNT_22903824_ChIP-Seq_MCF-7_Human0.72619274
137SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.72054809
138OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.71462552
139MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.71248417
140GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70731822
141P53_22127205_ChIP-Seq_FIBROBLAST_Human0.70260478

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.64933165
2MP0002822_catalepsy5.02267861
3MP0003635_abnormal_synaptic_transmissio3.76045865
4MP0003880_abnormal_central_pattern3.71106994
5MP0002837_dystrophic_cardiac_calcinosis3.52739125
6MP0009046_muscle_twitch3.10033629
7MP0009745_abnormal_behavioral_response3.07357158
8MP0002063_abnormal_learning/memory/cond2.97985687
9MP0000751_myopathy2.88152466
10MP0002064_seizures2.86320677
11MP0004270_analgesia2.47044220
12MP0002735_abnormal_chemical_nociception2.45857213
13MP0003646_muscle_fatigue2.43791395
14MP0002572_abnormal_emotion/affect_behav2.29701190
15MP0001968_abnormal_touch/_nociception2.23761749
16MP0001501_abnormal_sleep_pattern2.02399054
17MP0004858_abnormal_nervous_system1.99174473
18MP0002272_abnormal_nervous_system1.98068734
19MP0003329_amyloid_beta_deposits1.97442026
20MP0002736_abnormal_nociception_after1.95497250
21MP0001440_abnormal_grooming_behavior1.94627359
22MP0009780_abnormal_chondrocyte_physiolo1.92547529
23MP0002733_abnormal_thermal_nociception1.85565883
24MP0002734_abnormal_mechanical_nocicepti1.84849774
25MP0004215_abnormal_myocardial_fiber1.75316514
26MP0008569_lethality_at_weaning1.71475302
27MP0003123_paternal_imprinting1.69966553
28MP0001970_abnormal_pain_threshold1.67943928
29MP0001486_abnormal_startle_reflex1.67343166
30MP0000749_muscle_degeneration1.65155072
31MP0004924_abnormal_behavior1.63932771
32MP0005386_behavior/neurological_phenoty1.63932771
33MP0004233_abnormal_muscle_weight1.62245750
34MP0002909_abnormal_adrenal_gland1.61207566
35MP0002067_abnormal_sensory_capabilities1.56186481
36MP0004142_abnormal_muscle_tone1.54262815
37MP0002184_abnormal_innervation1.53505993
38MP0001984_abnormal_olfaction1.49026880
39MP0002249_abnormal_larynx_morphology1.48344986
40MP0004036_abnormal_muscle_relaxation1.43461897
41MP0006276_abnormal_autonomic_nervous1.38888363
42MP0004811_abnormal_neuron_physiology1.38143819
43MP0002557_abnormal_social/conspecific_i1.37716211
44MP0004484_altered_response_of1.36567634
45MP0000955_abnormal_spinal_cord1.35900049
46MP0002332_abnormal_exercise_endurance1.33283668
47MP0001529_abnormal_vocalization1.28901231
48MP0003075_altered_response_to1.27954098
49MP0003122_maternal_imprinting1.25929703
50MP0005171_absent_coat_pigmentation1.23161102
51MP0002066_abnormal_motor_capabilities/c1.23042070
52MP0005423_abnormal_somatic_nervous1.22074542
53MP0003137_abnormal_impulse_conducting1.21423851
54MP0005670_abnormal_white_adipose1.20139604
55MP0003879_abnormal_hair_cell1.19340931
56MP0002653_abnormal_ependyma_morphology1.18926375
57MP0004084_abnormal_cardiac_muscle1.17769068
58MP0000678_abnormal_parathyroid_gland1.17733858
59MP0001905_abnormal_dopamine_level1.16270747
60MP0003690_abnormal_glial_cell1.15104453
61MP0002882_abnormal_neuron_morphology1.14116480
62MP0004145_abnormal_muscle_electrophysio1.13972285
63MP0002269_muscular_atrophy1.11859519
64MP0004742_abnormal_vestibular_system1.10318231
65MP0001502_abnormal_circadian_rhythm1.09239401
66MP0003633_abnormal_nervous_system1.09183413
67MP0000778_abnormal_nervous_system1.09164018
68MP0000013_abnormal_adipose_tissue1.08648270
69MP0004130_abnormal_muscle_cell1.06707352
70MP0005330_cardiomyopathy1.06198345
71MP0000747_muscle_weakness1.05302082
72MP0002106_abnormal_muscle_physiology1.03931810
73MP0004087_abnormal_muscle_fiber1.02123957
74MP0005409_darkened_coat_color1.01881350
75MP0002229_neurodegeneration1.01341359
76MP0004085_abnormal_heartbeat1.01074606
77MP0000750_abnormal_muscle_regeneration0.99716920
78MP0003861_abnormal_nervous_system0.99616291
79MP0003172_abnormal_lysosome_physiology0.99302541
80MP0005623_abnormal_meninges_morphology0.97599910
81MP0001963_abnormal_hearing_physiology0.97434626
82MP0005620_abnormal_muscle_contractility0.96312807
83MP0002972_abnormal_cardiac_muscle0.94900303
84MP0000759_abnormal_skeletal_muscle0.94531437
85MP0003632_abnormal_nervous_system0.91378436
86MP0004510_myositis0.91053460
87MP0001986_abnormal_taste_sensitivity0.90504724
88MP0003121_genomic_imprinting0.90423373
89MP0002090_abnormal_vision0.90148338
90MP0000920_abnormal_myelination0.89273894
91MP0005369_muscle_phenotype0.89113906
92MP0003631_nervous_system_phenotype0.87868522
93MP0008874_decreased_physiological_sensi0.87622912
94MP0002152_abnormal_brain_morphology0.87329312
95MP0002752_abnormal_somatic_nervous0.84900344
96MP0003698_abnormal_male_reproductive0.83051490
97MP0001188_hyperpigmentation0.82852487
98MP0008961_abnormal_basal_metabolism0.80627412
99MP0005499_abnormal_olfactory_system0.80263192
100MP0005394_taste/olfaction_phenotype0.80263192
101MP0002089_abnormal_postnatal_growth/wei0.78598434
102MP0005646_abnormal_pituitary_gland0.78259022
103MP0000604_amyloidosis0.77221685
104MP0004885_abnormal_endolymph0.76253736
105MP0005535_abnormal_body_temperature0.75807766
106MP0001943_abnormal_respiration0.75539392
107MP0000003_abnormal_adipose_tissue0.75217330
108MP0001177_atelectasis0.74212231
109MP0003385_abnormal_body_wall0.73277296
110MP0002069_abnormal_eating/drinking_beha0.72777511
111MP0000026_abnormal_inner_ear0.72472935
112MP0006035_abnormal_mitochondrial_morpho0.71638140
113MP0010769_abnormal_survival0.71496311
114MP0010770_preweaning_lethality0.69647172
115MP0002082_postnatal_lethality0.69647172
116MP0005385_cardiovascular_system_phenoty0.68992274
117MP0001544_abnormal_cardiovascular_syste0.68992274
118MP0003787_abnormal_imprinting0.68177810
119MP0010768_mortality/aging0.67828953
120MP0006036_abnormal_mitochondrial_physio0.67736082
121MP0005410_abnormal_fertilization0.67395488
122MP0001299_abnormal_eye_distance/0.67104579
123MP0005166_decreased_susceptibility_to0.66990410
124MP0003634_abnormal_glial_cell0.66848646
125MP0008260_abnormal_autophagy0.66066414
126MP0000681_abnormal_thyroid_gland0.61732887
127MP0002081_perinatal_lethality0.61507921
128MP0000534_abnormal_ureter_morphology0.61382506
129MP0002638_abnormal_pupillary_reflex0.61139602
130MP0003938_abnormal_ear_development0.61053801
131MP0006138_congestive_heart_failure0.60507958
132MP0001348_abnormal_lacrimal_gland0.59093935
133MP0003183_abnormal_peptide_metabolism0.58864398
134MP0002161_abnormal_fertility/fecundity0.58176773
135MP0003115_abnormal_respiratory_system0.58050008
136MP0008872_abnormal_physiological_respon0.56670564

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.46680732
2Myokymia (HP:0002411)4.81175998
3Ankle clonus (HP:0011448)4.45078769
4Focal seizures (HP:0007359)4.40532305
5Visual hallucinations (HP:0002367)4.27715999
6Epileptic encephalopathy (HP:0200134)4.19679022
7Hyperventilation (HP:0002883)3.91946742
8Progressive cerebellar ataxia (HP:0002073)3.83229347
9Atonic seizures (HP:0010819)3.70656153
10Obstructive sleep apnea (HP:0002870)3.60303059
11Spastic gait (HP:0002064)3.60287730
12Exercise-induced myalgia (HP:0003738)3.58497313
13Dialeptic seizures (HP:0011146)3.51496693
14Acute necrotizing encephalopathy (HP:0006965)3.37641055
15Febrile seizures (HP:0002373)3.32906713
16Absence seizures (HP:0002121)3.25012465
17Pheochromocytoma (HP:0002666)3.23514055
18Urinary bladder sphincter dysfunction (HP:0002839)3.19569430
19Abnormal mitochondria in muscle tissue (HP:0008316)3.17150744
20Neurofibrillary tangles (HP:0002185)3.10155041
21Insomnia (HP:0100785)3.04786531
22Neuroendocrine neoplasm (HP:0100634)3.03799217
23Papilledema (HP:0001085)3.03441560
24Amblyopia (HP:0000646)2.93605107
25Generalized tonic-clonic seizures (HP:0002069)2.92959628
26Peripheral hypomyelination (HP:0007182)2.86208981
27Progressive macrocephaly (HP:0004481)2.84211237
28Acute encephalopathy (HP:0006846)2.83907780
29Hyperacusis (HP:0010780)2.77774793
30Sudden death (HP:0001699)2.76728186
31Exercise-induced muscle cramps (HP:0003710)2.76110021
32Cerebral inclusion bodies (HP:0100314)2.75517961
33Mitochondrial inheritance (HP:0001427)2.72678926
34Athetosis (HP:0002305)2.67829686
35Hand muscle atrophy (HP:0009130)2.66004367
36Impaired smooth pursuit (HP:0007772)2.65403079
37Dysdiadochokinesis (HP:0002075)2.63106256
38Dysmetric saccades (HP:0000641)2.62812843
39Genetic anticipation (HP:0003743)2.62260301
40Progressive inability to walk (HP:0002505)2.62028816
41Neoplasm of the peripheral nervous system (HP:0100007)2.60899791
42Neuronal loss in central nervous system (HP:0002529)2.59180208
43Distal upper limb amyotrophy (HP:0007149)2.58420381
44Upper limb amyotrophy (HP:0009129)2.58420381
45Abnormality of the calf musculature (HP:0001430)2.50831499
46Stereotypic behavior (HP:0000733)2.49597463
47Pointed chin (HP:0000307)2.47543405
48Polyphagia (HP:0002591)2.45749554
49Abnormal eating behavior (HP:0100738)2.44111802
50Gaze-evoked nystagmus (HP:0000640)2.41698488
51Truncal ataxia (HP:0002078)2.41537906
52Decreased circulating renin level (HP:0003351)2.40374341
53Delusions (HP:0000746)2.39202533
54Increased variability in muscle fiber diameter (HP:0003557)2.37335558
55Supranuclear gaze palsy (HP:0000605)2.35646797
56Turricephaly (HP:0000262)2.35527914
57Increased CSF lactate (HP:0002490)2.33919596
58Urinary urgency (HP:0000012)2.32865396
59Cerebral hypomyelination (HP:0006808)2.32801693
60Sleep apnea (HP:0010535)2.30323611
61Primary atrial arrhythmia (HP:0001692)2.30126576
62Depression (HP:0000716)2.30108882
63Myotonia (HP:0002486)2.29600045
64Prolonged QT interval (HP:0001657)2.25475989
65Abnormality of ocular smooth pursuit (HP:0000617)2.25212072
66Myoglobinuria (HP:0002913)2.24406164
67Limb dystonia (HP:0002451)2.24312015
68Calf muscle hypertrophy (HP:0008981)2.23586037
69Hypoventilation (HP:0002791)2.23255828
70Atrial fibrillation (HP:0005110)2.22577410
71Hepatocellular necrosis (HP:0001404)2.21567357
72Hypercortisolism (HP:0001578)2.21312196
73Impaired social interactions (HP:0000735)2.19587975
74Abnormal social behavior (HP:0012433)2.19587975
75Anxiety (HP:0000739)2.19341382
76Supraventricular tachycardia (HP:0004755)2.19279947
77Left ventricular hypertrophy (HP:0001712)2.19099958
78EEG with generalized epileptiform discharges (HP:0011198)2.17443034
79Failure to thrive in infancy (HP:0001531)2.15769459
80Intention tremor (HP:0002080)2.15669010
81Supraventricular arrhythmia (HP:0005115)2.15545061
82Akinesia (HP:0002304)2.13767364
83Broad-based gait (HP:0002136)2.13516202
84Lower limb muscle weakness (HP:0007340)2.12832099
85Cerebral edema (HP:0002181)2.12216113
86Abnormality of the corticospinal tract (HP:0002492)2.11463392
87Poor eye contact (HP:0000817)2.11043792
88Abnormal EKG (HP:0003115)2.11039581
89Clonus (HP:0002169)2.10491854
90Impaired vibratory sensation (HP:0002495)2.10456841
91Apathy (HP:0000741)2.09702660
92Muscle hypertrophy of the lower extremities (HP:0008968)2.09274768
93Hypsarrhythmia (HP:0002521)2.08734622
94Syncope (HP:0001279)2.08692277
95Abnormality of binocular vision (HP:0011514)2.08529577
96Diplopia (HP:0000651)2.08529577
97Megalencephaly (HP:0001355)2.08439907
98Renovascular hypertension (HP:0100817)2.08096617
99Ventricular fibrillation (HP:0001663)2.07934947
100Bundle branch block (HP:0011710)2.05562219
101Hammertoe (HP:0001765)2.04821132
102Bowel incontinence (HP:0002607)2.04307556
103Impaired vibration sensation in the lower limbs (HP:0002166)2.04256570
104Lower limb asymmetry (HP:0100559)2.02481319
105Epileptiform EEG discharges (HP:0011182)2.02197417
106Exercise intolerance (HP:0003546)2.01856057
107Narrow nasal bridge (HP:0000446)2.01594397
108Obsessive-compulsive behavior (HP:0000722)2.01229001
109Lactic acidosis (HP:0003128)1.98954083
110EMG: myopathic abnormalities (HP:0003458)1.98265497
111Annular pancreas (HP:0001734)1.97575929
112Postural instability (HP:0002172)1.97351146
113Status epilepticus (HP:0002133)1.97070565
114Action tremor (HP:0002345)1.96099587
115Drooling (HP:0002307)1.94624484
116Fetal akinesia sequence (HP:0001989)1.94341790
117Abnormality of skeletal muscle fiber size (HP:0012084)1.93431795
118Hemiplegia (HP:0002301)1.93055803
119Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.91642906
120Craniofacial dystonia (HP:0012179)1.91419339
121Hyperthyroidism (HP:0000836)1.87895000
122Lower limb amyotrophy (HP:0007210)1.87782775
123Dysmetria (HP:0001310)1.86735376
124Spastic tetraplegia (HP:0002510)1.86504273
125Absent speech (HP:0001344)1.85948206
126Deep palmar crease (HP:0006191)1.84866294
127Thickened helices (HP:0000391)1.84528578
128Diminished motivation (HP:0000745)1.84454707
129Hepatic necrosis (HP:0002605)1.84219916
130Torticollis (HP:0000473)1.83955143
131Hemiparesis (HP:0001269)1.83652929
132Emotional lability (HP:0000712)1.83258076
133Ventricular arrhythmia (HP:0004308)1.82961663
134Mutism (HP:0002300)1.82953626
135Rapidly progressive (HP:0003678)1.82249479
136Abnormality of alanine metabolism (HP:0010916)1.81970916
137Hyperalaninemia (HP:0003348)1.81970916
138Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.81970916
139Spinal canal stenosis (HP:0003416)1.81844697
140Abnormality of the lower motor neuron (HP:0002366)1.81334105
141Spastic tetraparesis (HP:0001285)1.81229956
142Split foot (HP:0001839)1.80932236
143Congenital malformation of the right heart (HP:0011723)1.80658234
144Double outlet right ventricle (HP:0001719)1.80658234
145Tetraplegia (HP:0002445)1.80502483
146Elfin facies (HP:0004428)1.80369902
147Abnormal large intestine physiology (HP:0012700)1.80346006
148Optic disc pallor (HP:0000543)1.79644555
149Bradykinesia (HP:0002067)1.79333003
150Excessive salivation (HP:0003781)1.79257348
151Poor suck (HP:0002033)1.76996132
152Focal dystonia (HP:0004373)1.76918484
153Truncus arteriosus (HP:0001660)1.73479545
154Attention deficit hyperactivity disorder (HP:0007018)1.72621838
155Abnormality of the aortic arch (HP:0012303)1.72279092
156Hypoplasia of the corpus callosum (HP:0002079)1.70777207
157Overriding aorta (HP:0002623)1.70140373

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.80074547
2NTRK33.67301458
3ARAF2.56545479
4MAP3K92.50344210
5MINK12.43961243
6MAP3K122.39106212
7CDK122.16337937
8MAP3K42.14479304
9MAP3K112.11021853
10LMTK22.00838448
11PLK22.00226102
12MAP2K71.99956028
13PDK31.87847632
14PDK41.87847632
15MAP3K101.87387346
16NTRK21.83474457
17PHKG11.79048258
18PHKG21.79048258
19MAP2K41.78918466
20CASK1.75294688
21DAPK21.74109663
22KSR21.70670809
23KSR11.60415061
24PINK11.56046270
25PDK21.55408809
26LATS21.54406828
27RIPK11.50942346
28DAPK11.50764767
29PAK61.49089976
30TESK11.45536439
31BRD41.27080999
32MARK11.25733824
33TTN1.25228582
34GRK51.24551896
35NEK11.22256671
36CDK51.18490722
37PRKCG1.17764463
38PKN21.16329447
39PTK2B1.15736278
40PRPF4B1.15284047
41MAP3K131.14578856
42TAOK21.12524949
43RIPK41.12124413
44BMX1.11992782
45CAMKK11.10628933
46MAPK121.08464470
47TAOK11.06768197
48PRKD31.06567990
49CAMK2A1.04915452
50SIK21.04064407
51CAMK1G1.03087237
52DYRK1A1.02929788
53SIK31.02783571
54RAF11.01368411
55MUSK1.00910799
56NME10.99864997
57SCYL20.98794623
58MAP3K10.97184121
59MAPK100.97176063
60NTRK10.95603443
61SIK10.95211003
62DAPK30.93319864
63TRIB30.90677042
64DDR20.88765612
65MAP3K60.88521509
66BRAF0.87625660
67SGK4940.86418559
68SGK2230.86418559
69CDK140.86265358
70MARK20.85960363
71CDK180.83210986
72CAMK1D0.81120828
73CDK190.80695339
74CDK150.76056213
75ICK0.75939678
76MAP3K50.75468800
77CAMKK20.74765503
78STK380.74743866
79FES0.74551131
80TNIK0.74512906
81PRKCE0.73854091
82CSNK1G20.73397565
83WNK10.72866504
84DYRK1B0.72193991
85ILK0.72039808
86MAP2K10.69699613
87RPS6KA20.69198501
88CAMK40.68513992
89TNK20.68481404
90ERBB40.68360987
91CDK11A0.67990192
92NEK60.64856625
93MYLK0.64206236
94CAMK2B0.63288508
95MTOR0.62791569
96STK110.61476127
97MAP3K70.60602357
98DMPK0.59978851
99RET0.59927720
100PAK30.59830093
101MAPK80.58661356
102ALK0.58565513
103MOS0.57757187
104UHMK10.56773306
105CAMK10.56603813
106PRKCZ0.56267175
107PRKD20.56142920
108GSK3B0.56068692
109ADRBK10.55815959
110MAP2K60.55169965
111TYRO30.54179548
112RPS6KA30.53810685
113MAPK130.53647692
114ROCK20.53304614
115BRSK10.51620960
116CAMK2D0.51462635
117PKN10.49625258
118FER0.49397505
119CDC42BPA0.48338022
120ERN10.47390948
121CAMK2G0.47303540
122MAPK150.46590547
123PDK10.45236039
124PRKAA10.43560327
125MAP4K20.43523522
126PRKCH0.41983165
127PDPK10.40978984
128CDK20.40260265
129EEF2K0.39830357
130PNCK0.38971054
131CDK10.38330246
132CCNB10.37714926
133SGK10.37667835
134ERBB20.36389945
135ROCK10.36315055
136SGK30.35648125
137CSNK1E0.35174122

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.82842915
2Nicotine addiction_Homo sapiens_hsa050333.31002717
3Collecting duct acid secretion_Homo sapiens_hsa049662.68436373
4Oxidative phosphorylation_Homo sapiens_hsa001902.64754056
5GABAergic synapse_Homo sapiens_hsa047272.52121965
6Cardiac muscle contraction_Homo sapiens_hsa042602.36115398
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.33516565
8Circadian entrainment_Homo sapiens_hsa047132.28741401
9Morphine addiction_Homo sapiens_hsa050322.22270900
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.18411458
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.18026600
12Parkinsons disease_Homo sapiens_hsa050122.15874480
13Olfactory transduction_Homo sapiens_hsa047401.95241171
14Long-term potentiation_Homo sapiens_hsa047201.92591786
15Amphetamine addiction_Homo sapiens_hsa050311.85471596
16Glutamatergic synapse_Homo sapiens_hsa047241.85419573
17Salivary secretion_Homo sapiens_hsa049701.77193861
18Alzheimers disease_Homo sapiens_hsa050101.76577821
19Vibrio cholerae infection_Homo sapiens_hsa051101.74213664
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.68782637
21Dopaminergic synapse_Homo sapiens_hsa047281.68575568
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.62200518
23Cholinergic synapse_Homo sapiens_hsa047251.59835214
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50854172
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50087823
26Insulin secretion_Homo sapiens_hsa049111.49382062
27Calcium signaling pathway_Homo sapiens_hsa040201.43036744
28Gastric acid secretion_Homo sapiens_hsa049711.40431978
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40415367
30Oxytocin signaling pathway_Homo sapiens_hsa049211.38779577
31Huntingtons disease_Homo sapiens_hsa050161.35267231
32Cocaine addiction_Homo sapiens_hsa050301.28315272
33Long-term depression_Homo sapiens_hsa047301.25589359
34Dilated cardiomyopathy_Homo sapiens_hsa054141.22981546
35Taste transduction_Homo sapiens_hsa047421.22291082
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.18576137
37Serotonergic synapse_Homo sapiens_hsa047261.16795485
38Renin secretion_Homo sapiens_hsa049241.13312710
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10889256
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09736349
41GnRH signaling pathway_Homo sapiens_hsa049121.08645951
42Gap junction_Homo sapiens_hsa045401.06611586
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00989902
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97678979
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97486382
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.94811286
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94229761
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.94042789
49Estrogen signaling pathway_Homo sapiens_hsa049150.91478180
50Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.90527112
51Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90422952
52Type I diabetes mellitus_Homo sapiens_hsa049400.90151378
53cAMP signaling pathway_Homo sapiens_hsa040240.89093094
54Melanogenesis_Homo sapiens_hsa049160.87845492
55Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86372849
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85500865
57Glioma_Homo sapiens_hsa052140.85141547
58Choline metabolism in cancer_Homo sapiens_hsa052310.85120665
59Prion diseases_Homo sapiens_hsa050200.84198969
60Notch signaling pathway_Homo sapiens_hsa043300.83765853
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82216618
62Vitamin B6 metabolism_Homo sapiens_hsa007500.80441307
63Carbon metabolism_Homo sapiens_hsa012000.79558647
64mRNA surveillance pathway_Homo sapiens_hsa030150.78861818
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78500443
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.74939066
67AMPK signaling pathway_Homo sapiens_hsa041520.74210372
68Inositol phosphate metabolism_Homo sapiens_hsa005620.74201043
69Butanoate metabolism_Homo sapiens_hsa006500.71901628
70Glucagon signaling pathway_Homo sapiens_hsa049220.71430063
71Pyruvate metabolism_Homo sapiens_hsa006200.67488191
72Rheumatoid arthritis_Homo sapiens_hsa053230.67292098
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66404251
74Pancreatic secretion_Homo sapiens_hsa049720.65135522
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.64500739
76Biosynthesis of amino acids_Homo sapiens_hsa012300.63468264
77ErbB signaling pathway_Homo sapiens_hsa040120.58970779
78Oocyte meiosis_Homo sapiens_hsa041140.58505411
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57626507
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.57436394
81Propanoate metabolism_Homo sapiens_hsa006400.56972094
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56446352
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55472841
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54964576
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.54347507
86Type II diabetes mellitus_Homo sapiens_hsa049300.54320232
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53939197
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.53725886
89Axon guidance_Homo sapiens_hsa043600.52869416
90Fatty acid biosynthesis_Homo sapiens_hsa000610.52656055
91Rap1 signaling pathway_Homo sapiens_hsa040150.52496188
92Lysine degradation_Homo sapiens_hsa003100.51604977
93MAPK signaling pathway_Homo sapiens_hsa040100.51480184
94Bile secretion_Homo sapiens_hsa049760.51018241
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50705613
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49674917
97HIF-1 signaling pathway_Homo sapiens_hsa040660.49116190
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48876102
99Non-small cell lung cancer_Homo sapiens_hsa052230.48727517
100Insulin signaling pathway_Homo sapiens_hsa049100.48414496
101Fructose and mannose metabolism_Homo sapiens_hsa000510.46738842
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46631991
103Prolactin signaling pathway_Homo sapiens_hsa049170.45506594
104Phagosome_Homo sapiens_hsa041450.43051007
105VEGF signaling pathway_Homo sapiens_hsa043700.42968951
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.42760737
107Arginine and proline metabolism_Homo sapiens_hsa003300.42180159
108Renal cell carcinoma_Homo sapiens_hsa052110.41756958
109Alcoholism_Homo sapiens_hsa050340.41040554
110Dorso-ventral axis formation_Homo sapiens_hsa043200.40378464
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.40371999
112Ras signaling pathway_Homo sapiens_hsa040140.39768402
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37640775
114Sulfur relay system_Homo sapiens_hsa041220.37043062
115Chronic myeloid leukemia_Homo sapiens_hsa052200.36554684
116Hippo signaling pathway_Homo sapiens_hsa043900.36418420
117Endometrial cancer_Homo sapiens_hsa052130.36303686
118Thyroid hormone synthesis_Homo sapiens_hsa049180.35916482
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35571401
120Endocytosis_Homo sapiens_hsa041440.35341640
121mTOR signaling pathway_Homo sapiens_hsa041500.33175728
122Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32119133
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28994981
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28190099

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