YME1L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)6.18471424
2nuclear pore complex assembly (GO:0051292)6.11278883
3pore complex assembly (GO:0046931)4.78994574
4purine nucleobase biosynthetic process (GO:0009113)4.63887193
5DNA unwinding involved in DNA replication (GO:0006268)4.52840802
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.38227289
7meiotic chromosome segregation (GO:0045132)4.30184258
8attachment of spindle microtubules to kinetochore (GO:0008608)4.18302674
9IMP biosynthetic process (GO:0006188)4.17657717
10nucleobase biosynthetic process (GO:0046112)4.12392997
11regulation of RNA export from nucleus (GO:0046831)4.04557800
12chromatin remodeling at centromere (GO:0031055)3.98498344
13CENP-A containing nucleosome assembly (GO:0034080)3.94965621
14sister chromatid segregation (GO:0000819)3.67674752
15positive regulation of mitotic sister chromatid separation (GO:1901970)3.64973803
16positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.64973803
17positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.64973803
18mitotic metaphase plate congression (GO:0007080)3.58682176
19histone H2B ubiquitination (GO:0033523)3.54564830
20COPII vesicle coating (GO:0048208)3.53234000
21regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.51753206
22regulation of translational fidelity (GO:0006450)3.49837914
23kinetochore organization (GO:0051383)3.47887702
24formation of translation preinitiation complex (GO:0001731)3.47289698
25DNA replication-independent nucleosome organization (GO:0034724)3.43588561
26DNA replication-independent nucleosome assembly (GO:0006336)3.43588561
27mitotic nuclear envelope disassembly (GO:0007077)3.38463329
28regulation of DNA endoreduplication (GO:0032875)3.36802129
29regulation of spindle organization (GO:0090224)3.36594207
30establishment of chromosome localization (GO:0051303)3.36578662
31regulation of nucleobase-containing compound transport (GO:0032239)3.33919021
32regulation of sister chromatid cohesion (GO:0007063)3.33688853
33IMP metabolic process (GO:0046040)3.31652002
34metaphase plate congression (GO:0051310)3.30300946
35regulation of centriole replication (GO:0046599)3.30085235
36establishment of integrated proviral latency (GO:0075713)3.28514054
37mitotic sister chromatid segregation (GO:0000070)3.27052079
38spindle checkpoint (GO:0031577)3.26727850
39resolution of meiotic recombination intermediates (GO:0000712)3.26098112
40protein K6-linked ubiquitination (GO:0085020)3.25316274
41protein localization to kinetochore (GO:0034501)3.25178974
42DNA replication-dependent nucleosome assembly (GO:0006335)3.24773692
43DNA replication-dependent nucleosome organization (GO:0034723)3.24773692
44histone exchange (GO:0043486)3.24435883
45embryonic process involved in female pregnancy (GO:0060136)3.24278535
46regulation of glucokinase activity (GO:0033131)3.22969070
47regulation of hexokinase activity (GO:1903299)3.22969070
48mitotic chromosome condensation (GO:0007076)3.21105502
49DNA replication checkpoint (GO:0000076)3.20213442
50membrane disassembly (GO:0030397)3.18267755
51nuclear envelope disassembly (GO:0051081)3.18267755
52negative regulation of DNA-dependent DNA replication (GO:2000104)3.17504299
53DNA double-strand break processing (GO:0000729)3.15495643
54DNA synthesis involved in DNA repair (GO:0000731)3.15093185
55regulation of mitotic metaphase/anaphase transition (GO:0030071)3.14212132
56postreplication repair (GO:0006301)3.12793410
57regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.04789765
58regulation of mitotic spindle checkpoint (GO:1903504)3.04789765
59COPI coating of Golgi vesicle (GO:0048205)3.03282405
60Golgi transport vesicle coating (GO:0048200)3.03282405
61regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.02959241
62regulation of helicase activity (GO:0051095)3.01811579
63regulation of sister chromatid segregation (GO:0033045)3.01646494
64regulation of mitotic sister chromatid separation (GO:0010965)3.01646494
65regulation of mitotic sister chromatid segregation (GO:0033047)3.01646494
66negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.01625465
67cell adhesion mediated by integrin (GO:0033627)3.01420297
68mitotic spindle checkpoint (GO:0071174)3.00457851
69protein export from nucleus (GO:0006611)2.99702761
70mitotic sister chromatid cohesion (GO:0007064)2.99422347
71paraxial mesoderm development (GO:0048339)2.98198901
72vesicle coating (GO:0006901)2.97441489
73spindle assembly checkpoint (GO:0071173)2.95640171
74negative regulation of DNA repair (GO:0045738)2.95167407
75monoubiquitinated protein deubiquitination (GO:0035520)2.94929307
76NLS-bearing protein import into nucleus (GO:0006607)2.93875783
77mitotic recombination (GO:0006312)2.92779787
78cellular protein complex localization (GO:0034629)2.91743734
79negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.88682534
80negative regulation of sister chromatid segregation (GO:0033046)2.88682534
81negative regulation of mitotic sister chromatid separation (GO:2000816)2.88682534
82negative regulation of mitotic sister chromatid segregation (GO:0033048)2.88682534
83cytoplasmic mRNA processing body assembly (GO:0033962)2.88025499
84DNA replication initiation (GO:0006270)2.87620569
85dosage compensation (GO:0007549)2.87571812
86retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.86520240
87mitotic G2/M transition checkpoint (GO:0044818)2.85281303
88regulation of translational termination (GO:0006449)2.84319435
89RNA stabilization (GO:0043489)2.84186663
90mRNA stabilization (GO:0048255)2.84186663
91regulation of mitotic spindle organization (GO:0060236)2.83850704
92sister chromatid cohesion (GO:0007062)2.83654062
93DNA topological change (GO:0006265)2.83511968
94chromosome segregation (GO:0007059)2.82854699
95mitotic spindle assembly checkpoint (GO:0007094)2.82768767
96DNA ligation (GO:0006266)2.82716265
97positive regulation of chromosome segregation (GO:0051984)2.80299694
98negative regulation of chromosome segregation (GO:0051985)2.79709210
99maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.79349022
100nuclear envelope organization (GO:0006998)2.77533542
101ER overload response (GO:0006983)2.77185989
102negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.74870841
103telomere maintenance via recombination (GO:0000722)2.74827157
104folic acid-containing compound biosynthetic process (GO:0009396)2.73831380
105somatic diversification of immune receptors via somatic mutation (GO:0002566)2.73683235
106somatic hypermutation of immunoglobulin genes (GO:0016446)2.73683235
107mRNA export from nucleus (GO:0006406)2.73391005
108ribosome assembly (GO:0042255)2.72896101
109chromosome condensation (GO:0030261)2.72557732
110mammary gland epithelial cell proliferation (GO:0033598)2.72511597
111regulation of chromosome segregation (GO:0051983)2.72377022
112regulation of centrosome cycle (GO:0046605)2.72256656
113histone-serine phosphorylation (GO:0035404)2.71703355
114DNA conformation change (GO:0071103)2.70699608
115regulation of nuclear cell cycle DNA replication (GO:0033262)2.70675413
116ATP-dependent chromatin remodeling (GO:0043044)2.69542301
117microtubule depolymerization (GO:0007019)2.69450940
118negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.69376630
119DNA strand elongation (GO:0022616)2.68844479
120DNA strand elongation involved in DNA replication (GO:0006271)2.68454029
121positive regulation of cell cycle checkpoint (GO:1901978)2.68397244
122regulation of protein polyubiquitination (GO:1902914)2.68081725
123protein complex localization (GO:0031503)2.67838381
124mRNA transport (GO:0051028)2.66820273
125RNA export from nucleus (GO:0006405)2.65189033
126DNA geometric change (GO:0032392)2.65125433
127viral mRNA export from host cell nucleus (GO:0046784)2.63914977
128regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.63610681
129negative regulation of cell cycle G2/M phase transition (GO:1902750)2.62608713
130regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.61265479
131DNA duplex unwinding (GO:0032508)2.61226286
132protein localization to chromosome, centromeric region (GO:0071459)2.60914974
133ribosome biogenesis (GO:0042254)2.60259944
134regulation of DNA damage checkpoint (GO:2000001)2.59129651
135protein localization to microtubule (GO:0035372)2.55724900
136regulation of transforming growth factor beta2 production (GO:0032909)2.55203387
137nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.54535542
138negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.51999512
139establishment of viral latency (GO:0019043)2.49215987
140regulation of NFAT protein import into nucleus (GO:0051532)2.48340998
141pre-miRNA processing (GO:0031054)2.48293215
142mitotic cytokinesis (GO:0000281)2.47061382
143double-strand break repair via nonhomologous end joining (GO:0006303)2.46969781
144non-recombinational repair (GO:0000726)2.46969781
145trophoblast giant cell differentiation (GO:0060707)2.46230932
146DNA packaging (GO:0006323)2.45859822
147spliceosomal tri-snRNP complex assembly (GO:0000244)2.45746542
148protein localization to chromosome (GO:0034502)2.41853954
149nucleobase-containing small molecule interconversion (GO:0015949)2.41809846
150regulation of centrosome duplication (GO:0010824)2.41769099
151cytoskeleton-dependent cytokinesis (GO:0061640)2.39754285
152protein retention in ER lumen (GO:0006621)2.39431311
153regulation of mRNA stability (GO:0043488)2.39042820
154ER-nucleus signaling pathway (GO:0006984)2.36907280
155regulation of glucose import in response to insulin stimulus (GO:2001273)2.36347326
156hemidesmosome assembly (GO:0031581)2.34927702
157heterochromatin organization (GO:0070828)2.33989361
158protein localization to endosome (GO:0036010)2.33816926
159endoplasmic reticulum unfolded protein response (GO:0030968)2.33326245
160negative regulation of fibroblast apoptotic process (GO:2000270)2.29902212
161positive regulation of DNA-templated transcription, elongation (GO:0032786)2.26791810
162histone monoubiquitination (GO:0010390)2.25128556

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.22932657
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.88527665
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.68432878
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.46096831
5* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.33327304
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.16112394
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.15927752
8TP63_17297297_ChIP-ChIP_HaCaT_Human3.03448734
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.96129215
10ELK1_19687146_ChIP-ChIP_HELA_Human2.81469199
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.73060333
12PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.66272698
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.63068512
14* MYC_18555785_ChIP-Seq_MESCs_Mouse2.52126007
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.49528461
16CLOCK_20551151_ChIP-Seq_293T_Human2.42315629
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.39221325
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.25733653
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.22391889
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.19642634
21* EST1_17652178_ChIP-ChIP_JURKAT_Human2.15942932
22AR_21909140_ChIP-Seq_LNCAP_Human2.15158106
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.13116942
24* E2F1_21310950_ChIP-Seq_MCF-7_Human2.10215650
25* GABP_17652178_ChIP-ChIP_JURKAT_Human2.03883982
26* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.99748351
27* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.95963786
28* VDR_23849224_ChIP-Seq_CD4+_Human1.91035053
29CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.90808062
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.90122524
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.89255969
32PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.84611616
33* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80361039
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.77662456
35ZNF263_19887448_ChIP-Seq_K562_Human1.77581987
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.76791063
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.76761045
38MYC_22102868_ChIP-Seq_BL_Human1.68698823
39SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.65671139
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64083060
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62515009
42KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55567342
43* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.53036125
44TP63_19390658_ChIP-ChIP_HaCaT_Human1.52657025
45FOXP3_21729870_ChIP-Seq_TREG_Human1.52132329
46FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.51797866
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.47403618
48* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.45131781
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.43727278
50MYC_19079543_ChIP-ChIP_MESCs_Mouse1.40795814
51* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.39593241
52TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37351050
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34772563
54SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.33710010
55CHD1_26751641_Chip-Seq_LNCaP_Human1.33617276
56SOX2_18555785_ChIP-Seq_MESCs_Mouse1.32874420
57DCP1A_22483619_ChIP-Seq_HELA_Human1.32649409
58SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.32076436
59TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.31407083
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30511136
61EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.29933210
62CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.29827975
63* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29799134
64TFEB_21752829_ChIP-Seq_HELA_Human1.29481595
65HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29470453
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28968768
67ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28206178
68EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.27805825
69* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.26278972
70HIF1A_21447827_ChIP-Seq_MCF-7_Human1.25838987
71* ETS1_20019798_ChIP-Seq_JURKAT_Human1.25734614
72CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.24959759
73SALL4_18804426_ChIP-ChIP_XEN_Mouse1.24330912
74TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22218948
75SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.21243269
76HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.20941662
77EWS_26573619_Chip-Seq_HEK293_Human1.18699709
78EGR1_23403033_ChIP-Seq_LIVER_Mouse1.18598382
79SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17368481
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15522381
81TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14694385
82* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14452840
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14376025
84GATA1_22025678_ChIP-Seq_K562_Human1.14248437
85FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.12844678
86SRF_21415370_ChIP-Seq_HL-1_Mouse1.11413954
87* GABP_19822575_ChIP-Seq_HepG2_Human1.10501839
88KDM5A_27292631_Chip-Seq_BREAST_Human1.10384231
89NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09824938
90CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06886160
91IRF8_22096565_ChIP-ChIP_GC-B_Human1.05183163
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04333796
93PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04306221
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03998566
95NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03931812
96WT1_19549856_ChIP-ChIP_CCG9911_Human1.03741574
97ATF3_27146783_Chip-Seq_COLON_Human1.03363739
98* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.02866194
99POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01689626
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01002832
101* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.00927860
102NANOG_21062744_ChIP-ChIP_HESCs_Human1.00851716
103ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00471558
104STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00029593
105XRN2_22483619_ChIP-Seq_HELA_Human0.99835996
106HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97799456
107CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97647444
108MYB_21317192_ChIP-Seq_ERMYB_Mouse0.97531358
109ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.96590200
110TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96239511
111FUS_26573619_Chip-Seq_HEK293_Human0.95331986
112TTF2_22483619_ChIP-Seq_HELA_Human0.95289593
113KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95150027
114P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94360312
115NANOG_16153702_ChIP-ChIP_HESCs_Human0.93944476
116THAP11_20581084_ChIP-Seq_MESCs_Mouse0.93660248
117UBF1/2_26484160_Chip-Seq_HMECs_Human0.92180279
118CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91078242
119SOX17_20123909_ChIP-Seq_XEN_Mouse0.90991640
120ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90200805
121BRD4_25478319_ChIP-Seq_HGPS_Human0.89761493
122IRF1_19129219_ChIP-ChIP_H3396_Human0.88258079
123ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85660752
124STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.84167203
125HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.83878831
126POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.82540380
127GATA4_21415370_ChIP-Seq_HL-1_Mouse0.81031391
128CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.79832048
129NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.79594989
130* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.78522415
131POU5F1_16153702_ChIP-ChIP_HESCs_Human0.78491202
132SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.77194305
133RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.76978075
134* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.76764424
135* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.76764424
136CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.76492961
137MYC_18940864_ChIP-ChIP_HL60_Human0.74405968

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.45802430
2MP0010094_abnormal_chromosome_stability3.26024227
3MP0002009_preneoplasia3.02655759
4MP0008007_abnormal_cellular_replicative2.87515232
5MP0008058_abnormal_DNA_repair2.77575406
6MP0009697_abnormal_copulation2.66797482
7MP0003077_abnormal_cell_cycle2.57677066
8MP0004957_abnormal_blastocyst_morpholog2.56321172
9MP0010234_abnormal_vibrissa_follicle2.39149539
10MP0003123_paternal_imprinting2.38924583
11MP0003111_abnormal_nucleus_morphology2.36907351
12MP0010307_abnormal_tumor_latency2.34625969
13MP0002877_abnormal_melanocyte_morpholog2.24616532
14MP0008877_abnormal_DNA_methylation2.14412027
15MP0010352_gastrointestinal_tract_polyps2.10205948
16MP0004272_abnormal_basement_membrane2.10098099
17MP0006054_spinal_hemorrhage2.08090636
18MP0003786_premature_aging2.07995519
19MP0004233_abnormal_muscle_weight2.04874538
20MP0003221_abnormal_cardiomyocyte_apopto2.03279587
21MP0008057_abnormal_DNA_replication1.97493408
22MP0004185_abnormal_adipocyte_glucose1.94175380
23MP0003121_genomic_imprinting1.88707455
24MP0000516_abnormal_urinary_system1.86212369
25MP0005367_renal/urinary_system_phenotyp1.86212369
26MP0003787_abnormal_imprinting1.84355785
27MP0002876_abnormal_thyroid_physiology1.83236419
28MP0002160_abnormal_reproductive_system1.82965912
29MP0005503_abnormal_tendon_morphology1.79011747
30MP0009053_abnormal_anal_canal1.71430563
31MP0005389_reproductive_system_phenotype1.66194280
32MP0008438_abnormal_cutaneous_collagen1.61004903
33MP0003806_abnormal_nucleotide_metabolis1.57029693
34MP0004197_abnormal_fetal_growth/weight/1.48333166
35MP0005408_hypopigmentation1.47763947
36MP0001919_abnormal_reproductive_system1.46697878
37MP0008932_abnormal_embryonic_tissue1.45866617
38MP0003705_abnormal_hypodermis_morpholog1.43982506
39MP0002166_altered_tumor_susceptibility1.43064815
40MP0003890_abnormal_embryonic-extraembry1.42749643
41MP0000537_abnormal_urethra_morphology1.42305790
42MP0000350_abnormal_cell_proliferation1.39422479
43MP0003950_abnormal_plasma_membrane1.38541214
44MP0001119_abnormal_female_reproductive1.34048664
45MP0005451_abnormal_body_composition1.33419044
46MP0001672_abnormal_embryogenesis/_devel1.32145554
47MP0005380_embryogenesis_phenotype1.32145554
48MP0002796_impaired_skin_barrier1.31638859
49MP0004782_abnormal_surfactant_physiolog1.31522820
50MP0002396_abnormal_hematopoietic_system1.29102972
51MP0003091_abnormal_cell_migration1.29069125
52MP0000733_abnormal_muscle_development1.27813238
53MP0001730_embryonic_growth_arrest1.26755253
54MP0002697_abnormal_eye_size1.25495212
55MP0005501_abnormal_skin_physiology1.21572381
56MP0005076_abnormal_cell_differentiation1.21055970
57MP0003984_embryonic_growth_retardation1.21015154
58MP0002088_abnormal_embryonic_growth/wei1.20752320
59MP0003943_abnormal_hepatobiliary_system1.19823292
60MP0000372_irregular_coat_pigmentation1.18222686
61MP0002006_tumorigenesis1.16933298
62MP0004808_abnormal_hematopoietic_stem1.15603873
63MP0001542_abnormal_bone_strength1.14985534
64MP0003315_abnormal_perineum_morphology1.14615825
65MP0002210_abnormal_sex_determination1.13238840
66MP0005623_abnormal_meninges_morphology1.12656905
67MP0002086_abnormal_extraembryonic_tissu1.10880491
68MP0001177_atelectasis1.10267782
69MP0000751_myopathy1.10261719
70MP0002139_abnormal_hepatobiliary_system1.09699052
71MP0005187_abnormal_penis_morphology1.08729188
72MP0003385_abnormal_body_wall1.07461238
73MP0000015_abnormal_ear_pigmentation1.06924678
74MP0001661_extended_life_span1.05645876
75MP0001216_abnormal_epidermal_layer1.05559100
76MP0002269_muscular_atrophy1.02735443
77MP0005257_abnormal_intraocular_pressure1.02150561
78MP0003300_gastrointestinal_ulcer1.01982260
79MP0009703_decreased_birth_body1.01068993
80MP0001697_abnormal_embryo_size1.00588276
81MP0004087_abnormal_muscle_fiber1.00567817
82MP0003941_abnormal_skin_development0.99987687
83MP0002092_abnormal_eye_morphology0.98585993
84MP0000762_abnormal_tongue_morphology0.98301532
85MP0005621_abnormal_cell_physiology0.98064784
86MP0010630_abnormal_cardiac_muscle0.97751380
87MP0003195_calcinosis0.97720790
88MP0000566_synostosis0.96486427
89MP0010678_abnormal_skin_adnexa0.95200967
90MP0001915_intracranial_hemorrhage0.94225009
91MP0003718_maternal_effect0.94113894
92MP0002095_abnormal_skin_pigmentation0.91416185
93MP0002098_abnormal_vibrissa_morphology0.90401624
94MP0003453_abnormal_keratinocyte_physiol0.89229142
95MP0001243_abnormal_dermal_layer0.89219343
96MP0005275_abnormal_skin_tensile0.89193315
97MP0002080_prenatal_lethality0.88976599
98MP0001764_abnormal_homeostasis0.87062602
99MP0003567_abnormal_fetal_cardiomyocyte0.85994720
100MP0002085_abnormal_embryonic_tissue0.85964512
101MP0000490_abnormal_crypts_of0.85885529
102MP0002084_abnormal_developmental_patter0.85770250
103MP0003937_abnormal_limbs/digits/tail_de0.85629226
104MP0000759_abnormal_skeletal_muscle0.85335904
105MP0001186_pigmentation_phenotype0.85255363
106MP0004264_abnormal_extraembryonic_tissu0.85111743
107MP0001835_abnormal_antigen_presentation0.85058192
108MP0001145_abnormal_male_reproductive0.84789216
109MP0000377_abnormal_hair_follicle0.84733090
110MP0000427_abnormal_hair_cycle0.84687748
111MP0002019_abnormal_tumor_incidence0.84106641
112MP0001881_abnormal_mammary_gland0.81991293
113MP0001879_abnormal_lymphatic_vessel0.81792972
114MP0009672_abnormal_birth_weight0.81643036
115MP0000681_abnormal_thyroid_gland0.81270382
116MP0002751_abnormal_autonomic_nervous0.81249319
117MP0003115_abnormal_respiratory_system0.81247345
118MP0001299_abnormal_eye_distance/0.80903711
119MP0005384_cellular_phenotype0.80717080
120MP0000747_muscle_weakness0.80682043
121MP0000653_abnormal_sex_gland0.80078756
122MP0004147_increased_porphyrin_level0.78947186
123MP0009384_cardiac_valve_regurgitation0.78946523
124MP0001188_hyperpigmentation0.77912915
125MP0000313_abnormal_cell_death0.77695936
126MP0001286_abnormal_eye_development0.77611507
127MP0003942_abnormal_urinary_system0.77555666
128MP0002925_abnormal_cardiovascular_devel0.77326652
129MP0000371_diluted_coat_color0.77192576
130MP0000627_abnormal_mammary_gland0.76240735
131MP0002896_abnormal_bone_mineralization0.75794265
132MP0000569_abnormal_digit_pigmentation0.75428108
133MP0005220_abnormal_exocrine_pancreas0.75167662
134MP0000579_abnormal_nail_morphology0.74617145
135MP0001727_abnormal_embryo_implantation0.73205516
136MP0002177_abnormal_outer_ear0.73074981
137MP0003566_abnormal_cell_adhesion0.72730239
138MP0001348_abnormal_lacrimal_gland0.72519429
139MP0003656_abnormal_erythrocyte_physiolo0.72165876
140MP0000647_abnormal_sebaceous_gland0.71852663
141MP0000428_abnormal_craniofacial_morphol0.71820539
142MP0004084_abnormal_cardiac_muscle0.71277925
143MP0002111_abnormal_tail_morphology0.70798533
144MP0001929_abnormal_gametogenesis0.70347945
145MP0003186_abnormal_redox_activity0.69865175
146MP0000432_abnormal_head_morphology0.69200203
147MP0002060_abnormal_skin_morphology0.68914533

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)3.59380979
2Abnormality of the anterior horn cell (HP:0006802)3.45817579
3Degeneration of anterior horn cells (HP:0002398)3.45817579
4Birth length less than 3rd percentile (HP:0003561)3.30531307
5Chromsome breakage (HP:0040012)3.10840838
6Cortical dysplasia (HP:0002539)3.06948405
7Syringomyelia (HP:0003396)2.98187118
8Spinal cord lesions (HP:0100561)2.98187118
9Cutaneous melanoma (HP:0012056)2.93276080
10Chromosomal breakage induced by crosslinking agents (HP:0003221)2.83311277
11Deep philtrum (HP:0002002)2.80607514
12Long clavicles (HP:0000890)2.80246731
13Protrusio acetabuli (HP:0003179)2.75633164
14Impulsivity (HP:0100710)2.73196598
15Abnormality of chromosome stability (HP:0003220)2.70102815
16Hyperacusis (HP:0010780)2.69790796
17Deviation of the thumb (HP:0009603)2.66139722
18Ankyloglossia (HP:0010296)2.61255919
19Arterial tortuosity (HP:0005116)2.55190791
20Type I transferrin isoform profile (HP:0003642)2.52289830
21Abnormality of oral frenula (HP:0000190)2.50334417
22Abnormality of the hip-girdle musculature (HP:0001445)2.50254985
23Abnormality of the musculature of the pelvis (HP:0001469)2.50254985
24Proximal placement of thumb (HP:0009623)2.50190459
25Subacute progressive viral hepatitis (HP:0006572)2.49030607
26Embryonal renal neoplasm (HP:0011794)2.48549186
27Hypothermia (HP:0002045)2.44521084
28Vertebral arch anomaly (HP:0008438)2.42044252
2911 pairs of ribs (HP:0000878)2.35520139
30Abnormal biliary tract morphology (HP:0012440)2.35399770
31Stillbirth (HP:0003826)2.34944913
32Colon cancer (HP:0003003)2.33987271
33Abnormality of the labia minora (HP:0012880)2.30153832
34Microglossia (HP:0000171)2.28983451
35Ectopic kidney (HP:0000086)2.28908980
36Increased nuchal translucency (HP:0010880)2.28044138
37Irregular epiphyses (HP:0010582)2.27352001
38Insomnia (HP:0100785)2.25788681
39Papillary thyroid carcinoma (HP:0002895)2.25631494
40Alveolar cell carcinoma (HP:0006519)2.25570092
41Insidious onset (HP:0003587)2.25253951
42Termporal pattern (HP:0011008)2.25253951
43Progressive muscle weakness (HP:0003323)2.25223602
44Nephroblastoma (Wilms tumor) (HP:0002667)2.24920368
45Asymmetry of the thorax (HP:0001555)2.23658184
46Curly hair (HP:0002212)2.22398726
47Nemaline bodies (HP:0003798)2.22289900
48Overlapping toe (HP:0001845)2.19773052
49Vascular tortuosity (HP:0004948)2.19348229
50Mesomelia (HP:0003027)2.15832512
51Osteolytic defects of the hand bones (HP:0009699)2.15737373
52Osteolytic defects of the phalanges of the hand (HP:0009771)2.15737373
53Abnormal foot bone ossification (HP:0010675)2.15147292
54Abnormal lung lobation (HP:0002101)2.14616697
55Leiomyosarcoma (HP:0100243)2.14052538
56Uterine leiomyosarcoma (HP:0002891)2.14052538
57Orthostatic hypotension (HP:0001278)2.13824309
58Meckel diverticulum (HP:0002245)2.13228554
59Entropion (HP:0000621)2.13130652
60Cystic hygroma (HP:0000476)2.12078130
61Ankle contracture (HP:0006466)2.11556942
62Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.11492701
63Progressive external ophthalmoplegia (HP:0000590)2.09928420
64Renal cortical cysts (HP:0000803)2.09240954
65Neoplasm of the tracheobronchial system (HP:0100552)2.06492120
66Selective tooth agenesis (HP:0001592)2.06481320
67Neoplasm of the adrenal cortex (HP:0100641)2.05595185
68Limb-girdle muscle atrophy (HP:0003797)2.05525976
69Thyroid carcinoma (HP:0002890)2.05499254
70Muscle fiber inclusion bodies (HP:0100299)2.05351735
71Gastrointestinal carcinoma (HP:0002672)2.04623791
72Malignant gastrointestinal tract tumors (HP:0006749)2.04623791
73Abnormal spermatogenesis (HP:0008669)2.01857123
74Patellar aplasia (HP:0006443)2.01220678
75Bladder diverticulum (HP:0000015)2.00356522
76Missing ribs (HP:0000921)2.00142251
77Aplasia/Hypoplasia of the uvula (HP:0010293)1.98932658
78Flat capital femoral epiphysis (HP:0003370)1.98480045
79Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.98215693
80Reduced antithrombin III activity (HP:0001976)1.98077692
81Neoplasm of the liver (HP:0002896)1.96945749
82Breast carcinoma (HP:0003002)1.96537322
83Biliary tract neoplasm (HP:0100574)1.96351035
84Limb hypertonia (HP:0002509)1.95680379
85Transitional cell carcinoma of the bladder (HP:0006740)1.94492748
86Agnosia (HP:0010524)1.94371258
87Gonadotropin excess (HP:0000837)1.94001618
88Rhabdomyosarcoma (HP:0002859)1.93219940
89Bladder neoplasm (HP:0009725)1.92986196
90Bladder carcinoma (HP:0002862)1.92986196
91Hyperglycemia (HP:0003074)1.92335193
92Long foot (HP:0001833)1.90960191
93Volvulus (HP:0002580)1.90179342
94Back pain (HP:0003418)1.89903567
95Spinal rigidity (HP:0003306)1.89111826
96Abnormality of the ileum (HP:0001549)1.88982672
97Limb-girdle muscle weakness (HP:0003325)1.87893628
98Centrally nucleated skeletal muscle fibers (HP:0003687)1.87714418
99Freckling (HP:0001480)1.87310775
100Aplasia/Hypoplasia of the patella (HP:0006498)1.87231782
101Medulloblastoma (HP:0002885)1.86799656
102Metaphyseal cupping (HP:0003021)1.86421733
103Abnormality of the left ventricular outflow tract (HP:0011103)1.85095436
104Subaortic stenosis (HP:0001682)1.85095436
105Hypochromic microcytic anemia (HP:0004840)1.84222670
106Flat acetabular roof (HP:0003180)1.84130703
107Abnormality of the calcaneus (HP:0008364)1.84068640
108Increased connective tissue (HP:0009025)1.83722866
109Pancreatic islet-cell hyperplasia (HP:0004510)1.83533161
110Intestinal atresia (HP:0011100)1.83528719
111Absent frontal sinuses (HP:0002688)1.83416245
112Aortic dissection (HP:0002647)1.83093854
113Small epiphyses (HP:0010585)1.82570334
114Acute myeloid leukemia (HP:0004808)1.82416378
115Abnormality of pyrimidine metabolism (HP:0004353)1.82082500
116Abnormality of the nasal septum (HP:0000419)1.80961669
117Type 1 muscle fiber predominance (HP:0003803)1.78769544
118Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.78076112
119Atrophic scars (HP:0001075)1.77088526
120Ovarian neoplasm (HP:0100615)1.76773402
121Calcaneovalgus deformity (HP:0001848)1.76721387
122Right ventricular cardiomyopathy (HP:0011663)1.76453048
123Facial cleft (HP:0002006)1.76400725
124Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.76061671
125Prominent metopic ridge (HP:0005487)1.75393780
126Abnormality of the metopic suture (HP:0005556)1.75373608
127Mildly elevated creatine phosphokinase (HP:0008180)1.75310581
128Distal lower limb amyotrophy (HP:0008944)1.74274457
129Duodenal stenosis (HP:0100867)1.74210933
130Small intestinal stenosis (HP:0012848)1.74210933
131Myelodysplasia (HP:0002863)1.73937816
132Renal duplication (HP:0000075)1.73515336
133Abnormality of the preputium (HP:0100587)1.73246296
134Capillary hemangiomas (HP:0005306)1.73220759
135Achilles tendon contracture (HP:0001771)1.72385829
136Exercise-induced myalgia (HP:0003738)1.72256180
137Multiple enchondromatosis (HP:0005701)1.71960330
138Breech presentation (HP:0001623)1.71853048
139Mitral valve prolapse (HP:0001634)1.71194812
140Abnormality of methionine metabolism (HP:0010901)1.70745123
141Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.70721185
142Abnormal protein N-linked glycosylation (HP:0012347)1.70721185
143Abnormal protein glycosylation (HP:0012346)1.70721185
144Abnormal glycosylation (HP:0012345)1.70721185
145Wormian bones (HP:0002645)1.69649947
146Elfin facies (HP:0004428)1.68164925
147Trismus (HP:0000211)1.67961846
148Shawl scrotum (HP:0000049)1.67463126
149Glioma (HP:0009733)1.67144554
150Abnormality of incisor morphology (HP:0011063)1.66297554
151Shoulder girdle muscle weakness (HP:0003547)1.65941286
152Abnormality of the ischium (HP:0003174)1.65659942
153Renovascular hypertension (HP:0100817)1.64636398
154Chronic hepatic failure (HP:0100626)1.64632174
155Overriding aorta (HP:0002623)1.64216529
156Rimmed vacuoles (HP:0003805)1.64035878
157Scapular winging (HP:0003691)1.63902498
158Abnormality of T cell number (HP:0011839)1.63796845
159Persistence of primary teeth (HP:0006335)1.63273917
160Spastic diplegia (HP:0001264)1.62935527
161Sandal gap (HP:0001852)1.62842860
162Carpal bone hypoplasia (HP:0001498)1.62449116
163Abnormality of the frontal sinuses (HP:0002687)1.61347670
164Broad face (HP:0000283)1.61017710
165Sloping forehead (HP:0000340)1.60769374
166Breast hypoplasia (HP:0003187)1.60636114
167Abnormality of nail color (HP:0100643)1.60367792
168Patellar dislocation (HP:0002999)1.60057172
169Clubbing of toes (HP:0100760)1.59946413
170Short 4th metacarpal (HP:0010044)1.59372930
171Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.59372930
172Abnormality of the distal phalanx of the thumb (HP:0009617)1.59130316
173Large earlobe (HP:0009748)1.58473695
174Abnormality of the duodenum (HP:0002246)1.58032715
175Relative macrocephaly (HP:0004482)1.56856172
176Tongue fasciculations (HP:0001308)1.56254397
177Pelvic girdle muscle weakness (HP:0003749)1.56193558

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK13.69893897
2ZAK3.35459233
3AKT33.08903735
4FRK3.07935691
5BRSK23.05528710
6MKNK22.86844486
7ERBB32.80752082
8ACVR1B2.67451055
9MKNK12.66582966
10SRPK12.48345331
11MAP3K102.24454321
12CDC72.19907204
13PLK32.12343879
14EIF2AK32.10509199
15PDGFRA2.09111764
16LATS22.04152080
17MAP3K142.03752478
18TTN1.96616675
19LATS11.93643925
20NUAK11.93598480
21STK38L1.89184294
22NEK91.82954183
23EIF2AK11.77666943
24NEK21.75658576
25IRAK31.70393696
26SGK21.67077648
27PASK1.66914068
28ICK1.66225851
29TRIB31.63598892
30PBK1.63546613
31EEF2K1.59160881
32PRPF4B1.58525178
33PNCK1.55201209
34PLK41.52832237
35TSSK61.49594729
36MST1R1.46919393
37BRD41.45510927
38WEE11.45274232
39SMG11.43971779
40SCYL21.40967121
41TAF11.37916597
42STK241.37830888
43YES11.32303643
44BRSK11.22482245
45PLK11.22166173
46SGK31.17487908
47PIM11.16176777
48TRPM71.14854780
49STK31.13876286
50KSR21.13842134
51EPHA31.10580678
52MST41.10450961
53MAP3K91.08551899
54EIF2AK21.08494911
55BUB11.08195317
56ATR1.06426691
57KSR11.06083767
58PAK41.04302989
59AURKB1.02982529
60CDK81.02739217
61TXK1.02440690
62MOS0.99305164
63PDK30.97601717
64PDK40.97601717
65PLK20.95945309
66FGFR40.94669558
67STK40.92906968
68CDK120.92047142
69FLT30.91715925
70FGFR30.88555508
71CHEK20.88018865
72MAP3K80.87107017
73CCNB10.87092418
74TTK0.87090275
75CASK0.86838226
76CHUK0.85621131
77MARK30.84902347
78ATM0.84118242
79CHEK10.82479361
80MET0.81426297
81VRK10.80745972
82RPS6KB10.80327669
83MTOR0.79856831
84BCR0.78725776
85TESK20.77456499
86TEC0.77344314
87NEK60.75772847
88TGFBR10.71354008
89EPHA20.71226444
90MELK0.68708123
91CDK60.68380717
92CDK90.66251531
93RPS6KB20.64931220
94RAF10.63123043
95PDK20.62721177
96JAK30.62063053
97DYRK30.61898753
98PAK20.61480282
99PDGFRB0.61057513
100INSRR0.59726647
101BMPR20.59241602
102BRAF0.56706803
103SIK30.56049550
104PKN20.54507419
105NTRK10.52680974
106SGK2230.51483444
107SGK4940.51483444
108PTK20.50786577
109SIK10.50131336
110MAP3K30.49206673
111CDK20.47606459
112CDK10.47573537
113LIMK10.47286819
114CAMK1G0.45913237
115CSNK2A10.45787360
116DYRK1B0.44746746
117ERBB40.44477952
118RPS6KA40.42521789
119OBSCN0.41554274
120MAP3K20.40990989
121ALK0.38975644
122CDK40.38840335
123PIK3CA0.37503999
124TLK10.36827741
125CSNK2A20.36753529
126RPS6KL10.36511230
127RPS6KC10.36511230
128CDK140.35550116
129CDK180.35115568
130CLK10.34197937
131NLK0.34124060
132MAPK110.33898820
133DMPK0.33770638
134AKT20.33725335
135MAP3K130.33117055
136STK100.32566602
137JAK10.31865704
138PRKCI0.30324714
139AURKA0.29725277
140FGFR10.29394216
141IKBKE0.28203397
142CDK70.27733875
143RPS6KA60.26896341
144WNK30.26653456
145IRAK40.25456280
146MAPK140.24739368

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.53173209
2DNA replication_Homo sapiens_hsa030303.22757193
3Mismatch repair_Homo sapiens_hsa034303.03044166
4One carbon pool by folate_Homo sapiens_hsa006702.93964215
5RNA transport_Homo sapiens_hsa030132.72751750
6Cell cycle_Homo sapiens_hsa041102.70970778
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.67404585
8Base excision repair_Homo sapiens_hsa034102.59643094
9Nucleotide excision repair_Homo sapiens_hsa034202.40762604
10Non-homologous end-joining_Homo sapiens_hsa034502.40108668
11Selenocompound metabolism_Homo sapiens_hsa004502.35674171
12Basal transcription factors_Homo sapiens_hsa030222.30990909
13Fanconi anemia pathway_Homo sapiens_hsa034602.23175500
14mRNA surveillance pathway_Homo sapiens_hsa030152.10738292
15Spliceosome_Homo sapiens_hsa030402.06053554
16Chronic myeloid leukemia_Homo sapiens_hsa052202.04340972
17Proteasome_Homo sapiens_hsa030502.04030688
18Homologous recombination_Homo sapiens_hsa034402.03445735
19RNA degradation_Homo sapiens_hsa030181.97772916
20Systemic lupus erythematosus_Homo sapiens_hsa053221.93479070
21RNA polymerase_Homo sapiens_hsa030201.82460675
22p53 signaling pathway_Homo sapiens_hsa041151.75386599
23Bladder cancer_Homo sapiens_hsa052191.70297093
24Antigen processing and presentation_Homo sapiens_hsa046121.68144306
25Protein export_Homo sapiens_hsa030601.67223354
26Pancreatic cancer_Homo sapiens_hsa052121.61786330
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.54105238
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.53741247
29Central carbon metabolism in cancer_Homo sapiens_hsa052301.53156175
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.41403806
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.39541829
32Pyrimidine metabolism_Homo sapiens_hsa002401.39387213
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.37924116
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.37580964
35Non-small cell lung cancer_Homo sapiens_hsa052231.35179416
36Thyroid cancer_Homo sapiens_hsa052161.32212245
37Renal cell carcinoma_Homo sapiens_hsa052111.29805169
38Viral carcinogenesis_Homo sapiens_hsa052031.28168128
39Shigellosis_Homo sapiens_hsa051311.25400489
40Legionellosis_Homo sapiens_hsa051341.24260590
41Proteoglycans in cancer_Homo sapiens_hsa052051.23019446
42Herpes simplex infection_Homo sapiens_hsa051681.20099701
43Steroid biosynthesis_Homo sapiens_hsa001001.18774806
44Epstein-Barr virus infection_Homo sapiens_hsa051691.15706900
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.12448002
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08010418
47Focal adhesion_Homo sapiens_hsa045101.06812634
48Acute myeloid leukemia_Homo sapiens_hsa052211.05074520
49Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01619389
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.01122932
51Pentose phosphate pathway_Homo sapiens_hsa000300.99941390
52Carbon metabolism_Homo sapiens_hsa012000.97373719
53N-Glycan biosynthesis_Homo sapiens_hsa005100.96174099
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.94338904
55Purine metabolism_Homo sapiens_hsa002300.93991791
56Measles_Homo sapiens_hsa051620.92670824
57Prolactin signaling pathway_Homo sapiens_hsa049170.91589709
58Adherens junction_Homo sapiens_hsa045200.88674696
59Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.86566256
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85184425
61Autoimmune thyroid disease_Homo sapiens_hsa053200.84163868
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81852173
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.81280624
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81035969
65ErbB signaling pathway_Homo sapiens_hsa040120.79628643
66Glioma_Homo sapiens_hsa052140.79068865
67Insulin signaling pathway_Homo sapiens_hsa049100.79062033
68TGF-beta signaling pathway_Homo sapiens_hsa043500.77455467
69Pathways in cancer_Homo sapiens_hsa052000.76890809
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76787091
71HTLV-I infection_Homo sapiens_hsa051660.75755193
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75245604
73MicroRNAs in cancer_Homo sapiens_hsa052060.74824688
74Notch signaling pathway_Homo sapiens_hsa043300.69345545
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69016208
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.68710989
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68563620
78Vitamin B6 metabolism_Homo sapiens_hsa007500.67507926
79Oocyte meiosis_Homo sapiens_hsa041140.66504660
80Prostate cancer_Homo sapiens_hsa052150.66046440
81Endometrial cancer_Homo sapiens_hsa052130.64402155
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64334836
83Inositol phosphate metabolism_Homo sapiens_hsa005620.63734777
84FoxO signaling pathway_Homo sapiens_hsa040680.62179428
85Small cell lung cancer_Homo sapiens_hsa052220.61628146
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60718546
87Tight junction_Homo sapiens_hsa045300.59451551
88Alcoholism_Homo sapiens_hsa050340.59319510
89mTOR signaling pathway_Homo sapiens_hsa041500.59171467
90Influenza A_Homo sapiens_hsa051640.57949096
91Type I diabetes mellitus_Homo sapiens_hsa049400.57843551
92AMPK signaling pathway_Homo sapiens_hsa041520.57432885
93Prion diseases_Homo sapiens_hsa050200.56703958
94Primary immunodeficiency_Homo sapiens_hsa053400.56308092
95Sulfur metabolism_Homo sapiens_hsa009200.56025666
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55544708
97Allograft rejection_Homo sapiens_hsa053300.54855245
98VEGF signaling pathway_Homo sapiens_hsa043700.54314983
99Graft-versus-host disease_Homo sapiens_hsa053320.53943375
100TNF signaling pathway_Homo sapiens_hsa046680.52882650
101Hippo signaling pathway_Homo sapiens_hsa043900.52270707
102Pyruvate metabolism_Homo sapiens_hsa006200.51086578
103Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51006136
104Amoebiasis_Homo sapiens_hsa051460.50103683
105HIF-1 signaling pathway_Homo sapiens_hsa040660.50077434
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.49917928
107Basal cell carcinoma_Homo sapiens_hsa052170.49382436
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49185299
109Wnt signaling pathway_Homo sapiens_hsa043100.48760555
1102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48745858
111Regulation of autophagy_Homo sapiens_hsa041400.47968000
112Apoptosis_Homo sapiens_hsa042100.47286073
113Hepatitis B_Homo sapiens_hsa051610.46607783
114Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46011659
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45900045
116Starch and sucrose metabolism_Homo sapiens_hsa005000.45475988
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43785187
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42037760
119Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40891951
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39047828
121Renin-angiotensin system_Homo sapiens_hsa046140.36679565
122Lysine degradation_Homo sapiens_hsa003100.36645327
123Galactose metabolism_Homo sapiens_hsa000520.35860223
124Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35357796
125Colorectal cancer_Homo sapiens_hsa052100.35259308
126PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34857652
127ECM-receptor interaction_Homo sapiens_hsa045120.34770130
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33314935
129Hematopoietic cell lineage_Homo sapiens_hsa046400.33060339
130Arachidonic acid metabolism_Homo sapiens_hsa005900.32316646
131Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32263761
132Hepatitis C_Homo sapiens_hsa051600.32193813
133Cysteine and methionine metabolism_Homo sapiens_hsa002700.31681423
134Vitamin digestion and absorption_Homo sapiens_hsa049770.30915486
135Folate biosynthesis_Homo sapiens_hsa007900.28098459
136NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26876197
137Phagosome_Homo sapiens_hsa041450.26391643
138Phenylalanine metabolism_Homo sapiens_hsa003600.26030803
139Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24906440
140Caffeine metabolism_Homo sapiens_hsa002320.24738525
141Melanoma_Homo sapiens_hsa052180.24104335
142Biosynthesis of amino acids_Homo sapiens_hsa012300.23652656
143Complement and coagulation cascades_Homo sapiens_hsa046100.22235269
144Jak-STAT signaling pathway_Homo sapiens_hsa046300.22015226

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