YPEL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is located in the region associated with DiGeorge syndrome on chromosome 22. The encoded protein localizes to the centrosome and nucleolus and may play a role in the regulation of cell division. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.81855006
2sperm motility (GO:0030317)9.04438998
3acrosome assembly (GO:0001675)8.80344923
4fusion of sperm to egg plasma membrane (GO:0007342)8.44939481
5axonemal dynein complex assembly (GO:0070286)8.14557702
6piRNA metabolic process (GO:0034587)7.89211868
7acrosome reaction (GO:0007340)7.86093391
8sperm-egg recognition (GO:0035036)7.85175351
9epithelial cilium movement (GO:0003351)7.70026695
10cell wall macromolecule metabolic process (GO:0044036)7.35750845
11cell wall macromolecule catabolic process (GO:0016998)7.35750845
12multicellular organism reproduction (GO:0032504)7.30382718
13binding of sperm to zona pellucida (GO:0007339)7.26932827
14motile cilium assembly (GO:0044458)7.05898810
15cell-cell recognition (GO:0009988)6.93357874
16spermatid development (GO:0007286)6.85845373
17cilium movement (GO:0003341)6.81557928
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.72684475
19male meiosis (GO:0007140)6.64746550
20plasma membrane fusion (GO:0045026)6.49969283
21synaptonemal complex organization (GO:0070193)6.12084037
22microtubule depolymerization (GO:0007019)6.04204237
23regulation of cilium movement (GO:0003352)6.01472966
24synaptonemal complex assembly (GO:0007130)5.89997793
25reproduction (GO:0000003)5.86941993
26behavioral response to nicotine (GO:0035095)5.52172562
27DNA methylation involved in gamete generation (GO:0043046)5.51557377
28single fertilization (GO:0007338)5.02127880
29spermatid nucleus differentiation (GO:0007289)4.75472434
30spermatogenesis (GO:0007283)4.66429288
31male gamete generation (GO:0048232)4.65069719
32male meiosis I (GO:0007141)4.57261192
33ventricular system development (GO:0021591)4.42061404
34chromosome organization involved in meiosis (GO:0070192)4.38706860
35negative regulation of inclusion body assembly (GO:0090084)4.34707397
36fertilization (GO:0009566)4.33612934
37gamete generation (GO:0007276)4.28905606
38cell recognition (GO:0008037)4.23603692
39calcium ion-dependent exocytosis (GO:0017156)4.22884429
40sperm capacitation (GO:0048240)4.21766205
41germ cell development (GO:0007281)4.12174306
42meiotic nuclear division (GO:0007126)4.06781660
43cellular process involved in reproduction in multicellular organism (GO:0022412)4.00177589
44postsynaptic membrane organization (GO:0001941)3.95226347
45protein localization to cilium (GO:0061512)3.91410760
46presynaptic membrane assembly (GO:0097105)3.91001317
47microtubule severing (GO:0051013)3.90759416
48intraciliary transport (GO:0042073)3.82852672
49cell migration in hindbrain (GO:0021535)3.81668906
50regulation of microtubule-based movement (GO:0060632)3.74012107
51presynaptic membrane organization (GO:0097090)3.72431139
52neuron fate determination (GO:0048664)3.70380170
53seminiferous tubule development (GO:0072520)3.70142631
54meiosis I (GO:0007127)3.70065968
55negative regulation of organelle assembly (GO:1902116)3.68199538
56pyrimidine nucleobase catabolic process (GO:0006208)3.60551716
57regulation of inclusion body assembly (GO:0090083)3.57515275
58activated T cell proliferation (GO:0050798)3.54935816
59axon ensheathment in central nervous system (GO:0032291)3.48466645
60central nervous system myelination (GO:0022010)3.48466645
61left/right pattern formation (GO:0060972)3.47937107
62limb bud formation (GO:0060174)3.37165095
63meiotic cell cycle (GO:0051321)3.35841819
64membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.31289469
65ionotropic glutamate receptor signaling pathway (GO:0035235)3.30340574
66protein-DNA complex disassembly (GO:0032986)3.30141674
67nucleosome disassembly (GO:0006337)3.30141674
68protein polyglutamylation (GO:0018095)3.30135353
69multicellular organismal reproductive process (GO:0048609)3.29969753
70cilium organization (GO:0044782)3.23208710
71microtubule polymerization or depolymerization (GO:0031109)3.22857024
72somite development (GO:0061053)3.22163105
73transmission of nerve impulse (GO:0019226)3.19192160
74forebrain neuron differentiation (GO:0021879)3.19181667
75cilium assembly (GO:0042384)3.18283941
76gamma-aminobutyric acid transport (GO:0015812)3.15493331
77nonmotile primary cilium assembly (GO:0035058)3.15466198
78G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.15373245
79regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.14364051
80neural tube formation (GO:0001841)3.14038163
81spinal cord development (GO:0021510)3.13931613
82glutamate receptor signaling pathway (GO:0007215)3.11614076
83hindbrain development (GO:0030902)3.09744336
84neuronal action potential (GO:0019228)3.08388432
85organic cation transport (GO:0015695)3.07998995
86single strand break repair (GO:0000012)3.07564070
87microtubule-based movement (GO:0007018)3.07237648
88vocalization behavior (GO:0071625)3.06067229
89cerebral cortex radially oriented cell migration (GO:0021799)3.04816146
90membrane depolarization during action potential (GO:0086010)3.04755227
91regulation of synapse structural plasticity (GO:0051823)3.03347469
92synaptic vesicle maturation (GO:0016188)3.02661347
93response to pheromone (GO:0019236)3.01436235
94positive regulation of oligodendrocyte differentiation (GO:0048714)3.01286485
95somite rostral/caudal axis specification (GO:0032525)2.99730576
96cerebellar Purkinje cell differentiation (GO:0021702)2.96737271
97regulation of action potential (GO:0098900)2.96234097
98positive regulation of gastrulation (GO:2000543)2.95950117
99protein localization to synapse (GO:0035418)2.95554311
100neuromuscular synaptic transmission (GO:0007274)2.94944130
101axoneme assembly (GO:0035082)2.94838231
102negative regulation of synaptic transmission, GABAergic (GO:0032229)2.94537136
103synaptic transmission, glutamatergic (GO:0035249)2.94505053
104auditory behavior (GO:0031223)2.93582650
105gene silencing by RNA (GO:0031047)2.91026495
106retinal ganglion cell axon guidance (GO:0031290)2.90634700
107neuronal action potential propagation (GO:0019227)2.89951051
108cell differentiation in spinal cord (GO:0021515)2.89194935
109multicellular organismal development (GO:0007275)2.88454976
110synapsis (GO:0007129)2.87812043
111neuronal stem cell maintenance (GO:0097150)2.87052468
112positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.86219328
113mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.86219328
114DNA packaging (GO:0006323)2.85382364
115spinal cord motor neuron differentiation (GO:0021522)2.84818461
116central nervous system projection neuron axonogenesis (GO:0021952)2.84580989
117positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.83333503
118cellular component assembly involved in morphogenesis (GO:0010927)2.82933107
119chromosome condensation (GO:0030261)2.82517248
120synapse assembly (GO:0007416)2.79395340
121positive regulation of action potential (GO:0045760)2.78643920
122dendrite morphogenesis (GO:0048813)2.77133065
123RNA localization (GO:0006403)2.76517080
124protein K11-linked deubiquitination (GO:0035871)2.76366483
125meiotic cell cycle process (GO:1903046)2.75764886
126regulation of chromatin binding (GO:0035561)2.75653017
127neurotransmitter-gated ion channel clustering (GO:0072578)2.74788052
128central nervous system neuron axonogenesis (GO:0021955)2.74219328
129cilium morphogenesis (GO:0060271)2.74137394
130positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.73493189
131mitotic sister chromatid cohesion (GO:0007064)2.72104913
132regulation of spindle checkpoint (GO:0090231)2.69252189
133kidney morphogenesis (GO:0060993)2.67745585
134GTP biosynthetic process (GO:0006183)2.67418752
135olfactory bulb development (GO:0021772)2.66848864
136neuron cell-cell adhesion (GO:0007158)2.66464336
137synaptic transmission, cholinergic (GO:0007271)2.66274630
138nucleobase catabolic process (GO:0046113)2.65768376
139otic vesicle formation (GO:0030916)2.65641357
140startle response (GO:0001964)2.63940189
141adult walking behavior (GO:0007628)2.63381807
142negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.61948178
143negative regulation of translation, ncRNA-mediated (GO:0040033)2.61948178
144regulation of translation, ncRNA-mediated (GO:0045974)2.61948178
145DNA methylation (GO:0006306)2.61288395
146DNA alkylation (GO:0006305)2.61288395
147spinal cord association neuron differentiation (GO:0021527)2.61012646
148regulation of meiosis I (GO:0060631)2.60941849
149regulation of synaptic transmission, glutamatergic (GO:0051966)2.59977800
150monoubiquitinated protein deubiquitination (GO:0035520)2.59508340
151positive regulation of dendritic spine morphogenesis (GO:0061003)2.58241714
152genitalia morphogenesis (GO:0035112)2.57451140
153nucleoside diphosphate phosphorylation (GO:0006165)2.56883013
154regulation of centriole replication (GO:0046599)2.56500662
155dendrite development (GO:0016358)2.56347853
156positive regulation of synapse assembly (GO:0051965)2.56072075
157histone exchange (GO:0043486)2.55747116
158L-fucose catabolic process (GO:0042355)2.55117606
159fucose catabolic process (GO:0019317)2.55117606
160L-fucose metabolic process (GO:0042354)2.55117606
161detection of light stimulus involved in sensory perception (GO:0050962)2.54763622
162detection of light stimulus involved in visual perception (GO:0050908)2.54763622
163neurofilament cytoskeleton organization (GO:0060052)2.53216138
164mechanosensory behavior (GO:0007638)2.52756116
165negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.52326479
166neuron maturation (GO:0042551)2.52258218
167retinal cone cell development (GO:0046549)2.51954004
168neuron-neuron synaptic transmission (GO:0007270)2.51690993
169exploration behavior (GO:0035640)2.51655879
170centriole assembly (GO:0098534)2.50892819
171dendritic spine morphogenesis (GO:0060997)2.50669132
172head development (GO:0060322)2.50235425
173substrate-independent telencephalic tangential migration (GO:0021826)2.48671498
174substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.48671498
175urinary tract smooth muscle contraction (GO:0014848)2.47505735
176membrane depolarization (GO:0051899)2.46350710
177negative regulation of axon extension (GO:0030517)2.46268976
178negative regulation of transcription regulatory region DNA binding (GO:2000678)2.46246048
179centriole replication (GO:0007099)2.45554778
180neuron migration (GO:0001764)2.45090201
181histone H2A acetylation (GO:0043968)2.43826503
182neuron recognition (GO:0008038)2.43008168
183regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.42452180
184female gonad development (GO:0008585)2.38437365
185nucleus organization (GO:0006997)2.36280136
186axonal fasciculation (GO:0007413)2.35208719
187sequestering of actin monomers (GO:0042989)2.35123154

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.56561933
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.61662552
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.37085227
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.92350095
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.80937056
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.51285920
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.48448145
8ZNF274_21170338_ChIP-Seq_K562_Hela2.44604253
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.41120918
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.20271489
11REST_21632747_ChIP-Seq_MESCs_Mouse2.14956654
12GBX2_23144817_ChIP-Seq_PC3_Human2.05807550
13RNF2_27304074_Chip-Seq_NSC_Mouse1.88854321
14FLI1_27457419_Chip-Seq_LIVER_Mouse1.86774745
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86404918
16VDR_22108803_ChIP-Seq_LS180_Human1.83969862
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77840200
18EED_16625203_ChIP-ChIP_MESCs_Mouse1.77002208
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76310324
20GATA1_26923725_Chip-Seq_HPCs_Mouse1.71826793
21JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69431600
22DROSHA_22980978_ChIP-Seq_HELA_Human1.69376407
23AR_21572438_ChIP-Seq_LNCaP_Human1.68228134
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66456059
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63644542
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60399790
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.59792649
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.58024382
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.55936702
30EWS_26573619_Chip-Seq_HEK293_Human1.54423979
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.53466612
32* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.52901439
33TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50026029
34POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.50026029
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.47159552
36FUS_26573619_Chip-Seq_HEK293_Human1.46891978
37TAF15_26573619_Chip-Seq_HEK293_Human1.46298004
38KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.45666024
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.44073986
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.43843635
41TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43273843
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41237443
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.37578421
44EZH2_18974828_ChIP-Seq_MESCs_Mouse1.37578421
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36722786
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36639421
47ELK4_26923725_Chip-Seq_MESODERM_Mouse1.36500264
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35062391
49RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.33615570
50MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.32992157
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32668793
52SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.32414567
53STAT3_23295773_ChIP-Seq_U87_Human1.31362553
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.30397410
55AR_25329375_ChIP-Seq_VCAP_Human1.30286318
56RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27959235
57REST_18959480_ChIP-ChIP_MESCs_Mouse1.27079174
58RNF2_27304074_Chip-Seq_ESCs_Mouse1.26134717
59TAL1_26923725_Chip-Seq_HPCs_Mouse1.25545279
60SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.24271475
61TP63_19390658_ChIP-ChIP_HaCaT_Human1.24175163
62KDM2B_26808549_Chip-Seq_REH_Human1.23740891
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23087863
64EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22845773
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.22529603
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.22369483
67SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.21696577
68RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20752848
69WDR5_24793694_ChIP-Seq_LNCAP_Human1.20642080
70MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19341071
71TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.18039569
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17698102
73PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16905196
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16846959
75RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16581678
76CBP_20019798_ChIP-Seq_JUKART_Human1.16398844
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16398844
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16107152
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15499718
80P53_22387025_ChIP-Seq_ESCs_Mouse1.15226507
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14332006
82TP53_22573176_ChIP-Seq_HFKS_Human1.13833695
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13656368
84IRF1_19129219_ChIP-ChIP_H3396_Human1.13042203
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12826018
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12096445
87IGF1R_20145208_ChIP-Seq_DFB_Human1.11998027
88SOX9_26525672_Chip-Seq_HEART_Mouse1.11805253
89SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.11551408
90CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11382580
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11307739
92CMYC_18555785_Chip-Seq_ESCs_Mouse1.09625511
93JARID2_20064375_ChIP-Seq_MESCs_Mouse1.09562845
94RUNX2_22187159_ChIP-Seq_PCA_Human1.08599239
95* SOX2_21211035_ChIP-Seq_LN229_Gbm1.08346547
96* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07049066
97SMAD4_21799915_ChIP-Seq_A2780_Human1.07027202
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06465220
99EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05658197
100SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05645362
101BCAT_22108803_ChIP-Seq_LS180_Human1.05190720
102SMAD3_21741376_ChIP-Seq_EPCs_Human1.05070352
103P300_18555785_Chip-Seq_ESCs_Mouse1.04751284
104P300_19829295_ChIP-Seq_ESCs_Human1.04713119
105EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04666166
106IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04171638
107RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03324309
108SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03263379
109E2F1_18555785_Chip-Seq_ESCs_Mouse1.03191416
110CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02452753
111OCT4_18555785_Chip-Seq_ESCs_Mouse1.01555849
112EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00704017
113SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99733363
114ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98368165
115LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98211947
116STAT3_18555785_Chip-Seq_ESCs_Mouse0.97787651
117TCF4_23295773_ChIP-Seq_U87_Human0.97721908
118KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97371042
119RUNX1_26923725_Chip-Seq_HPCs_Mouse0.96366128
120KLF4_18555785_Chip-Seq_ESCs_Mouse0.95698914
121SOX2_22085726_ChIP-Seq_NPCs_Mouse0.94786484
122STAT1_17558387_ChIP-Seq_HELA_Human0.94766880
123ER_23166858_ChIP-Seq_MCF-7_Human0.93321917
124SALL1_21062744_ChIP-ChIP_HESCs_Human0.93140981
125FLI1_21867929_ChIP-Seq_TH2_Mouse0.92111706
126SOX2_18555785_Chip-Seq_ESCs_Mouse0.92033250
127RUNX1_27457419_Chip-Seq_LIVER_Mouse0.91029394
128HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.90616376
129TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90009606
130ESRRB_18555785_Chip-Seq_ESCs_Mouse0.89776771
131PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89475749
132NMYC_18555785_Chip-Seq_ESCs_Mouse0.89263562
133SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.88773921
134TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87606564
135UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87365726
136RING1B_27294783_Chip-Seq_ESCs_Mouse0.87315334
137CTCF_18555785_Chip-Seq_ESCs_Mouse0.85368178

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.54128648
2MP0008877_abnormal_DNA_methylation4.10971916
3MP0003698_abnormal_male_reproductive3.94433728
4MP0001929_abnormal_gametogenesis3.52886558
5MP0004859_abnormal_synaptic_plasticity2.80281553
6MP0002210_abnormal_sex_determination2.71659890
7MP0003880_abnormal_central_pattern2.55196725
8MP0000569_abnormal_digit_pigmentation2.49091781
9MP0002102_abnormal_ear_morphology2.48762450
10MP0002653_abnormal_ependyma_morphology2.47771499
11MP0000778_abnormal_nervous_system2.23847655
12MP0001145_abnormal_male_reproductive2.20031190
13MP0002161_abnormal_fertility/fecundity2.19059031
14MP0002822_catalepsy2.18094465
15MP0004885_abnormal_endolymph2.16595723
16MP0005423_abnormal_somatic_nervous2.11114431
17MP0004142_abnormal_muscle_tone2.03784636
18MP0003136_yellow_coat_color2.02642041
19MP0000653_abnormal_sex_gland1.95430926
20MP0003635_abnormal_synaptic_transmissio1.89464179
21MP0002063_abnormal_learning/memory/cond1.85625269
22MP0004270_analgesia1.79476123
23MP0003787_abnormal_imprinting1.72932395
24MP0008058_abnormal_DNA_repair1.72114984
25MP0001970_abnormal_pain_threshold1.63184522
26MP0001984_abnormal_olfaction1.62586321
27MP0006276_abnormal_autonomic_nervous1.58904744
28MP0006292_abnormal_olfactory_placode1.56595994
29MP0002160_abnormal_reproductive_system1.55052946
30MP0002572_abnormal_emotion/affect_behav1.54216103
31MP0001968_abnormal_touch/_nociception1.51755042
32MP0001485_abnormal_pinna_reflex1.49836551
33MP0009745_abnormal_behavioral_response1.44458758
34MP0002557_abnormal_social/conspecific_i1.39937453
35MP0002184_abnormal_innervation1.39920156
36MP0009046_muscle_twitch1.37974348
37MP0003283_abnormal_digestive_organ1.37037609
38MP0001486_abnormal_startle_reflex1.34167670
39MP0010094_abnormal_chromosome_stability1.33979800
40MP0001440_abnormal_grooming_behavior1.33354632
41MP0003861_abnormal_nervous_system1.33193454
42MP0001529_abnormal_vocalization1.30248126
43MP0004145_abnormal_muscle_electrophysio1.28678145
44MP0004811_abnormal_neuron_physiology1.27792005
45MP0000015_abnormal_ear_pigmentation1.26735683
46MP0002736_abnormal_nociception_after1.25043649
47MP0002734_abnormal_mechanical_nocicepti1.21163784
48MP0001501_abnormal_sleep_pattern1.21036317
49MP0002152_abnormal_brain_morphology1.20368814
50MP0001905_abnormal_dopamine_level1.20346339
51MP0003121_genomic_imprinting1.18623342
52MP0001986_abnormal_taste_sensitivity1.18333933
53MP0000631_abnormal_neuroendocrine_gland1.18040015
54MP0003315_abnormal_perineum_morphology1.17933994
55MP0002282_abnormal_trachea_morphology1.17133882
56MP0001188_hyperpigmentation1.13685679
57MP0002234_abnormal_pharynx_morphology1.13654286
58MP0005409_darkened_coat_color1.13403050
59MP0008995_early_reproductive_senescence1.13386818
60MP0002928_abnormal_bile_duct1.12155114
61MP0002735_abnormal_chemical_nociception1.10759209
62MP0002064_seizures1.10197521
63MP0002882_abnormal_neuron_morphology1.08840125
64MP0000955_abnormal_spinal_cord1.08381847
65MP0004742_abnormal_vestibular_system1.07121420
66MP0005174_abnormal_tail_pigmentation1.05883625
67MP0005195_abnormal_posterior_eye1.04505431
68MP0005645_abnormal_hypothalamus_physiol1.03897426
69MP0002938_white_spotting1.02763904
70MP0002067_abnormal_sensory_capabilities1.02733663
71MP0008872_abnormal_physiological_respon1.02012580
72MP0000049_abnormal_middle_ear1.00418061
73MP0008569_lethality_at_weaning0.97419442
74MP0002272_abnormal_nervous_system0.96587765
75MP0000566_synostosis0.96364853
76MP0004133_heterotaxia0.92908723
77MP0003122_maternal_imprinting0.92744526
78MP0005499_abnormal_olfactory_system0.91623458
79MP0005394_taste/olfaction_phenotype0.91623458
80MP0002751_abnormal_autonomic_nervous0.91614651
81MP0008789_abnormal_olfactory_epithelium0.90504453
82MP0000537_abnormal_urethra_morphology0.90199793
83MP0009379_abnormal_foot_pigmentation0.90159208
84MP0002837_dystrophic_cardiac_calcinosis0.89500685
85MP0005389_reproductive_system_phenotype0.89247983
86MP0000026_abnormal_inner_ear0.89233587
87MP0003111_abnormal_nucleus_morphology0.88839863
88MP0003890_abnormal_embryonic-extraembry0.88265235
89MP0004130_abnormal_muscle_cell0.88205112
90MP0002752_abnormal_somatic_nervous0.88044835
91MP0008057_abnormal_DNA_replication0.87243526
92MP0003938_abnormal_ear_development0.85243672
93MP0002638_abnormal_pupillary_reflex0.82764729
94MP0003567_abnormal_fetal_cardiomyocyte0.82659771
95MP0004043_abnormal_pH_regulation0.82570133
96MP0003119_abnormal_digestive_system0.82234279
97MP0003879_abnormal_hair_cell0.82172939
98MP0001919_abnormal_reproductive_system0.80560080
99MP0005646_abnormal_pituitary_gland0.80337641
100MP0003646_muscle_fatigue0.80275487
101MP0002733_abnormal_thermal_nociception0.79907012
102MP0005386_behavior/neurological_phenoty0.79449230
103MP0004924_abnormal_behavior0.79449230
104MP0008007_abnormal_cellular_replicative0.79379540
105MP0002229_neurodegeneration0.78837826
106MP0003942_abnormal_urinary_system0.78442048
107MP0005551_abnormal_eye_electrophysiolog0.77837283
108MP0002116_abnormal_craniofacial_bone0.75848775
109MP0005391_vision/eye_phenotype0.75209850
110MP0002909_abnormal_adrenal_gland0.75137632
111MP0001293_anophthalmia0.75089644
112MP0002069_abnormal_eating/drinking_beha0.74705404
113MP0004233_abnormal_muscle_weight0.74703667
114MP0005084_abnormal_gallbladder_morpholo0.73591637
115MP0005253_abnormal_eye_physiology0.73539291
116MP0002066_abnormal_motor_capabilities/c0.73167548
117MP0005623_abnormal_meninges_morphology0.73104508
118MP0003115_abnormal_respiratory_system0.73095532
119MP0005377_hearing/vestibular/ear_phenot0.73047343
120MP0003878_abnormal_ear_physiology0.73047343
121MP0003786_premature_aging0.73044444
122MP0001963_abnormal_hearing_physiology0.71530939
123MP0001502_abnormal_circadian_rhythm0.71189000
124MP0003385_abnormal_body_wall0.67944461
125MP0009250_abnormal_appendicular_skeleto0.67517882
126MP0006072_abnormal_retinal_apoptosis0.66671099
127MP0002177_abnormal_outer_ear0.64018844

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.96216109
2Dynein arm defect of respiratory motile cilia (HP:0012255)9.82793046
3Absent/shortened dynein arms (HP:0200106)9.82793046
4Abnormal respiratory motile cilium physiology (HP:0012261)7.40103015
5Abnormal respiratory epithelium morphology (HP:0012253)7.17244489
6Abnormal respiratory motile cilium morphology (HP:0005938)7.17244489
7Abnormal ciliary motility (HP:0012262)6.15160606
8Rhinitis (HP:0012384)5.88554563
9Chronic bronchitis (HP:0004469)5.09820483
10Infertility (HP:0000789)4.62970229
11Nephronophthisis (HP:0000090)4.02751863
12Nasal polyposis (HP:0100582)3.35164355
13Bronchiectasis (HP:0002110)3.17306664
14Congenital stationary night blindness (HP:0007642)3.14178461
15Medial flaring of the eyebrow (HP:0010747)3.12043818
16Abnormality of the renal medulla (HP:0100957)3.05242340
17Amyotrophic lateral sclerosis (HP:0007354)3.00221684
18Abnormality of the lower motor neuron (HP:0002366)2.85899291
19Molar tooth sign on MRI (HP:0002419)2.80782943
20Abnormality of midbrain morphology (HP:0002418)2.80782943
21Protruding tongue (HP:0010808)2.80400914
22Septo-optic dysplasia (HP:0100842)2.71029344
23Type II lissencephaly (HP:0007260)2.70599080
24Tubulointerstitial nephritis (HP:0001970)2.70148634
25Bronchitis (HP:0012387)2.69129834
26Chronic hepatic failure (HP:0100626)2.67477925
27Abnormality of the labia minora (HP:0012880)2.59707198
28Gait imbalance (HP:0002141)2.58979113
29Drooling (HP:0002307)2.58210250
30Impulsivity (HP:0100710)2.51285565
31Broad-based gait (HP:0002136)2.49661666
32Excessive salivation (HP:0003781)2.42147803
33Abnormality of the nasal mucosa (HP:0000433)2.42094887
34Rib fusion (HP:0000902)2.41529779
35Optic nerve hypoplasia (HP:0000609)2.41072453
36Inability to walk (HP:0002540)2.40361610
37Postaxial foot polydactyly (HP:0001830)2.32634091
38Genetic anticipation (HP:0003743)2.32289246
39Abnormality of the renal cortex (HP:0011035)2.30640442
40Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.29838975
41Absent speech (HP:0001344)2.28659255
42Progressive inability to walk (HP:0002505)2.23789077
43Lissencephaly (HP:0001339)2.21814855
44Male infertility (HP:0003251)2.21386726
45Gonadotropin excess (HP:0000837)2.21354417
46Fibular hypoplasia (HP:0003038)2.20513208
47Patellar aplasia (HP:0006443)2.19157109
48Congenital primary aphakia (HP:0007707)2.18091845
49Pancreatic fibrosis (HP:0100732)2.17992411
50Oligodactyly (hands) (HP:0001180)2.15046880
51Postaxial hand polydactyly (HP:0001162)2.14926355
52Supernumerary spleens (HP:0009799)2.13150486
53Attenuation of retinal blood vessels (HP:0007843)2.12747056
54Cerebellar dysplasia (HP:0007033)2.12100556
55Pachygyria (HP:0001302)2.08880195
56Nephrogenic diabetes insipidus (HP:0009806)2.05943406
57Recurrent otitis media (HP:0000403)2.04035559
58Facial cleft (HP:0002006)1.99633746
59True hermaphroditism (HP:0010459)1.98739996
60Aplasia/Hypoplasia of the patella (HP:0006498)1.98147319
61Bilateral microphthalmos (HP:0007633)1.97682201
62Atonic seizures (HP:0010819)1.97432501
63Dialeptic seizures (HP:0011146)1.94370242
64Renal dysplasia (HP:0000110)1.94105648
65Tubular atrophy (HP:0000092)1.93046127
66Tubulointerstitial abnormality (HP:0001969)1.92956226
67Hypoplasia of the brainstem (HP:0002365)1.92530285
68Aplasia/Hypoplasia of the brainstem (HP:0007362)1.92530285
69Recurrent sinusitis (HP:0011108)1.92232876
70Concave nail (HP:0001598)1.91659668
71Median cleft lip (HP:0000161)1.91337204
72Abnormal spermatogenesis (HP:0008669)1.90793660
73Hypoplastic iliac wings (HP:0002866)1.90434140
74Intestinal atresia (HP:0011100)1.89542359
75Volvulus (HP:0002580)1.88808876
76Agitation (HP:0000713)1.88279341
77Action tremor (HP:0002345)1.88218704
78Aplasia/Hypoplasia of the lens (HP:0008063)1.87874874
79Anterior segment dysgenesis (HP:0007700)1.87622945
80Anophthalmia (HP:0000528)1.87100978
81Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.85654751
82Short 4th metacarpal (HP:0010044)1.85654751
83Growth hormone deficiency (HP:0000824)1.85468024
84Hip dysplasia (HP:0001385)1.85400447
853-Methylglutaconic aciduria (HP:0003535)1.83657856
86Birth length less than 3rd percentile (HP:0003561)1.83197611
87Intellectual disability, severe (HP:0010864)1.82160580
88Partial agenesis of the corpus callosum (HP:0001338)1.81954647
89Congenital hepatic fibrosis (HP:0002612)1.81636532
90Oculomotor apraxia (HP:0000657)1.80772995
91Aplasia/Hypoplasia of the sternum (HP:0006714)1.79390331
92Severe muscular hypotonia (HP:0006829)1.79254910
93Epileptic encephalopathy (HP:0200134)1.78997377
94Preaxial hand polydactyly (HP:0001177)1.78471808
95Progressive cerebellar ataxia (HP:0002073)1.74236846
96Exotropia (HP:0000577)1.72744936
97Focal motor seizures (HP:0011153)1.68317793
98Nephroblastoma (Wilms tumor) (HP:0002667)1.68218209
99Absent septum pellucidum (HP:0001331)1.68204398
100Aplasia/Hypoplasia of the tongue (HP:0010295)1.67555395
101Genital tract atresia (HP:0001827)1.66795174
102Microglossia (HP:0000171)1.66204069
103Sleep apnea (HP:0010535)1.65255916
104Generalized tonic-clonic seizures (HP:0002069)1.65108041
105Short ribs (HP:0000773)1.63960749
106Poor eye contact (HP:0000817)1.63896090
107Status epilepticus (HP:0002133)1.63706718
108Heterotopia (HP:0002282)1.63417375
109Prolonged QT interval (HP:0001657)1.63108981
110Hemiplegia (HP:0002301)1.63000315
111Renal cortical cysts (HP:0000803)1.62422489
112Vaginal atresia (HP:0000148)1.61200539
113Abnormal eating behavior (HP:0100738)1.61026268
114Pancreatic cysts (HP:0001737)1.60042113
115Macroglossia (HP:0000158)1.59996555
116Large eyes (HP:0001090)1.59309495
117Narrow forehead (HP:0000341)1.59089223
118Retinal dysplasia (HP:0007973)1.58000348
119Abnormality of ocular smooth pursuit (HP:0000617)1.57030465
120Ectopic kidney (HP:0000086)1.56712091
121Renovascular hypertension (HP:0100817)1.56471047
122Gaze-evoked nystagmus (HP:0000640)1.56425000
123Focal seizures (HP:0007359)1.54994990
124Embryonal renal neoplasm (HP:0011794)1.54826054
125Poor coordination (HP:0002370)1.52786758
126Anencephaly (HP:0002323)1.52670919
127Aplasia/Hypoplasia of the fibula (HP:0006492)1.52299107
128Limb dystonia (HP:0002451)1.51299224
129Specific learning disability (HP:0001328)1.49980911
130Decreased central vision (HP:0007663)1.49971412
131Abnormal drinking behavior (HP:0030082)1.49540847
132Polydipsia (HP:0001959)1.49540847
133Hypoplasia of the capital femoral epiphysis (HP:0003090)1.49306892
134Hemiparesis (HP:0001269)1.49006900
135Polyphagia (HP:0002591)1.48039184
136Stage 5 chronic kidney disease (HP:0003774)1.47995546
137Occipital encephalocele (HP:0002085)1.47304293
138Sclerocornea (HP:0000647)1.45970968
139Elfin facies (HP:0004428)1.43950020
140Abnormality of the dental root (HP:0006486)1.41947753
141Taurodontia (HP:0000679)1.41947753
142Abnormality of permanent molar morphology (HP:0011071)1.41947753
143Chronic sinusitis (HP:0011109)1.41391069
144Absent frontal sinuses (HP:0002688)1.41377906
145Megalocornea (HP:0000485)1.40899089
146Aplasia/Hypoplasia of the uvula (HP:0010293)1.40727752
147Cystic liver disease (HP:0006706)1.40328499
148Aganglionic megacolon (HP:0002251)1.39890249
149Broad distal phalanx of finger (HP:0009836)1.39452342
150Hyperventilation (HP:0002883)1.39366346
151Febrile seizures (HP:0002373)1.37009466
152Choroideremia (HP:0001139)1.36807823
153Myokymia (HP:0002411)1.35819259
154Mutism (HP:0002300)1.35466017

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK46.22089595
2PDK36.22089595
3MARK14.30420034
4TESK13.57383389
5PDK23.51964473
6PRKD33.34358669
7ICK2.99171950
8MAP4K22.35879036
9PNCK2.12950161
10NTRK22.08323617
11VRK11.97423000
12MAPK131.86870980
13MAP2K71.84751670
14CCNB11.78784868
15DYRK21.77496702
16FRK1.72846957
17ADRBK21.64662470
18DYRK31.61187222
19TAOK31.59849957
20TNIK1.57078685
21MINK11.55433579
22CASK1.52361982
23MAP3K41.51062251
24PTK2B1.48927091
25EPHA41.48484242
26ZAK1.48074246
27ERBB31.46299112
28NTRK31.42469122
29SRPK11.28355511
30MAPK151.25833926
31TRIM281.25814963
32KSR11.22484373
33GRK11.19546861
34INSRR1.19449091
35STK161.16917673
36SIK31.16850821
37CDC71.16327389
38NEK21.11442385
39STK381.05943138
40TYRO31.05876365
41CAMK1D1.02439943
42WNK41.01244564
43TLK10.99680944
44WNK30.99227077
45STK390.98328447
46IRAK20.97990352
47DYRK1B0.95877036
48ACVR1B0.95059916
49BCR0.94903282
50UHMK10.90058292
51CHEK20.88904631
52NUAK10.88613852
53SGK20.87102539
54PAK30.85267216
55CDK190.85066675
56CAMKK20.84142942
57SIK20.84084074
58MKNK20.81320775
59PASK0.81172522
60TAF10.80938783
61PLK20.78944690
62BMPR1B0.78768904
63NLK0.77847953
64PRKCG0.77179387
65FES0.75915805
66CAMK10.73886134
67PRKCE0.73721773
68CAMK40.71444551
69DYRK1A0.70482785
70ATR0.69380778
71MARK20.66864309
72TNK20.66671596
73ADRBK10.65715625
74TGFBR10.64757753
75IRAK10.64729467
76OXSR10.64717654
77PRPF4B0.63921935
78EPHA30.63082402
79OBSCN0.62810078
80CDK180.62702029
81BRAF0.62700071
82MKNK10.62267131
83YES10.62070962
84CDK50.60148196
85PLK40.58855921
86EPHB20.58705831
87PIK3CA0.57443375
88BRD40.56004020
89DAPK20.55486988
90MAPKAPK50.54848317
91DAPK10.54579482
92CDK150.53499050
93PAK60.50262061
94KIT0.49310141
95CHEK10.49062917
96CDK140.48081399
97PRKG10.48024322
98CDK11A0.47778037
99PRKACA0.47685572
100SGK10.47526152
101PDK10.47188130
102PHKG20.46290822
103PHKG10.46290822
104MAP2K60.46056407
105PINK10.45472724
106BUB10.44374588
107CSNK1G20.44212363
108PLK10.43079135
109CSNK1D0.42156758
110PRKCQ0.42138609
111MAP2K40.42009732
112PKN10.41050543
113TTK0.41041193
114PRKCZ0.39827802
115AURKA0.38959393
116CAMK1G0.38344420
117STK110.37936432
118PRKAA10.37583183
119ATM0.37272316
120MAPK80.36866779
121CAMKK10.36435462
122RIPK40.34622204
123TIE10.34300626
124CAMK2A0.33963546
125CSNK1G10.33924152
126CSNK1E0.33887253
127RPS6KB10.33851438
128PLK30.33822153
129STK38L0.33027095
130MAP3K120.32551953
131MARK30.31947742
132MAP3K100.31894603
133SGK4940.31265651
134SGK2230.31265651
135WEE10.31127495
136FGFR20.31046316
137NEK60.30003929
138BRSK10.29232106
139LATS20.29138769
140GRK70.29013758
141CDK10.28855280
142MUSK0.27392392
143MAP3K90.26472605
144TAOK20.25711052
145BMPR20.25203076
146CDK30.24936300

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.73197165
2Basal transcription factors_Homo sapiens_hsa030222.53542327
3Amphetamine addiction_Homo sapiens_hsa050312.35056285
4Oocyte meiosis_Homo sapiens_hsa041142.27324261
5Fanconi anemia pathway_Homo sapiens_hsa034602.27210235
6Long-term potentiation_Homo sapiens_hsa047202.07685066
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.95819339
8Axon guidance_Homo sapiens_hsa043601.85240260
9mRNA surveillance pathway_Homo sapiens_hsa030151.83419913
10Glutamatergic synapse_Homo sapiens_hsa047241.83171873
11Circadian entrainment_Homo sapiens_hsa047131.74500502
12Olfactory transduction_Homo sapiens_hsa047401.63074200
13Synaptic vesicle cycle_Homo sapiens_hsa047211.60157935
14Dopaminergic synapse_Homo sapiens_hsa047281.58843106
15Vitamin B6 metabolism_Homo sapiens_hsa007501.56830660
16Dorso-ventral axis formation_Homo sapiens_hsa043201.56153189
17Glucagon signaling pathway_Homo sapiens_hsa049221.55935062
18Oxidative phosphorylation_Homo sapiens_hsa001901.55351748
19Renin secretion_Homo sapiens_hsa049241.50024645
20Hedgehog signaling pathway_Homo sapiens_hsa043401.45207716
21Taste transduction_Homo sapiens_hsa047421.42320059
22Morphine addiction_Homo sapiens_hsa050321.41801570
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.41748166
24Parkinsons disease_Homo sapiens_hsa050121.41675450
25Spliceosome_Homo sapiens_hsa030401.38706041
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37886428
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37858201
28Nitrogen metabolism_Homo sapiens_hsa009101.37361343
29Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.36956917
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.33054252
31Alcoholism_Homo sapiens_hsa050341.28187529
32RNA transport_Homo sapiens_hsa030131.27994275
33Regulation of autophagy_Homo sapiens_hsa041401.27151841
34Butanoate metabolism_Homo sapiens_hsa006501.26665792
35Basal cell carcinoma_Homo sapiens_hsa052171.25092421
36Cocaine addiction_Homo sapiens_hsa050301.22643594
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19805490
38Wnt signaling pathway_Homo sapiens_hsa043101.19080112
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.16663144
40Huntingtons disease_Homo sapiens_hsa050161.16622898
41Insulin secretion_Homo sapiens_hsa049111.15166210
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.14081913
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.13865563
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13240284
45Fatty acid biosynthesis_Homo sapiens_hsa000611.13007277
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.10102918
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.10033695
48Homologous recombination_Homo sapiens_hsa034401.08489547
49Cell cycle_Homo sapiens_hsa041101.08079018
50Ovarian steroidogenesis_Homo sapiens_hsa049131.07065417
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06476785
52Calcium signaling pathway_Homo sapiens_hsa040201.04368973
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04342128
54Cholinergic synapse_Homo sapiens_hsa047251.03649432
55Linoleic acid metabolism_Homo sapiens_hsa005911.03428260
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03162272
57Estrogen signaling pathway_Homo sapiens_hsa049151.02992920
58DNA replication_Homo sapiens_hsa030301.01879774
59Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01275082
60Nucleotide excision repair_Homo sapiens_hsa034201.01235935
61Selenocompound metabolism_Homo sapiens_hsa004501.00138722
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.96971205
63Oxytocin signaling pathway_Homo sapiens_hsa049210.96877785
64Alzheimers disease_Homo sapiens_hsa050100.96224162
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95996953
66Purine metabolism_Homo sapiens_hsa002300.94784037
67GABAergic synapse_Homo sapiens_hsa047270.94481058
68Serotonergic synapse_Homo sapiens_hsa047260.93157783
69Phototransduction_Homo sapiens_hsa047440.92397507
70Melanogenesis_Homo sapiens_hsa049160.88583621
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87599981
72Salivary secretion_Homo sapiens_hsa049700.85237438
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.85190412
74Cardiac muscle contraction_Homo sapiens_hsa042600.84677606
75Endometrial cancer_Homo sapiens_hsa052130.84328304
76Caffeine metabolism_Homo sapiens_hsa002320.83928594
77ErbB signaling pathway_Homo sapiens_hsa040120.82968003
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81853262
79Base excision repair_Homo sapiens_hsa034100.79320029
80Ether lipid metabolism_Homo sapiens_hsa005650.78915149
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78665723
82VEGF signaling pathway_Homo sapiens_hsa043700.78637162
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78145558
84cAMP signaling pathway_Homo sapiens_hsa040240.78079281
85Pyruvate metabolism_Homo sapiens_hsa006200.75394168
86Mismatch repair_Homo sapiens_hsa034300.75008504
87Pyrimidine metabolism_Homo sapiens_hsa002400.74396318
88Long-term depression_Homo sapiens_hsa047300.73257299
89Systemic lupus erythematosus_Homo sapiens_hsa053220.72855194
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70909719
91Glioma_Homo sapiens_hsa052140.70510164
92Gastric acid secretion_Homo sapiens_hsa049710.68576136
93RNA degradation_Homo sapiens_hsa030180.67617919
94Colorectal cancer_Homo sapiens_hsa052100.66422292
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64880487
96Gap junction_Homo sapiens_hsa045400.63746978
97Collecting duct acid secretion_Homo sapiens_hsa049660.62707357
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62472269
99Hippo signaling pathway_Homo sapiens_hsa043900.61999805
100Tryptophan metabolism_Homo sapiens_hsa003800.61925670
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59300160
102ABC transporters_Homo sapiens_hsa020100.56560583
103Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55636429
104Non-homologous end-joining_Homo sapiens_hsa034500.55396002
105Notch signaling pathway_Homo sapiens_hsa043300.53112499
106Circadian rhythm_Homo sapiens_hsa047100.52969675
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52834213
108T cell receptor signaling pathway_Homo sapiens_hsa046600.51994738
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50683108
110GnRH signaling pathway_Homo sapiens_hsa049120.50573301
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50198552
112Choline metabolism in cancer_Homo sapiens_hsa052310.48129326
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47578157
114MAPK signaling pathway_Homo sapiens_hsa040100.47546900
115Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46453740
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.44023854
117Epstein-Barr virus infection_Homo sapiens_hsa051690.43682760
118Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43331927
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.43320962
120Primary immunodeficiency_Homo sapiens_hsa053400.43051123
121Type II diabetes mellitus_Homo sapiens_hsa049300.43031900
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42006569
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.41356377
124N-Glycan biosynthesis_Homo sapiens_hsa005100.41353259
125Ribosome_Homo sapiens_hsa030100.41273191
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41018207
127Ras signaling pathway_Homo sapiens_hsa040140.40271952
128Arachidonic acid metabolism_Homo sapiens_hsa005900.35893859
129Histidine metabolism_Homo sapiens_hsa003400.32616975
130Protein export_Homo sapiens_hsa030600.31279431
131Peroxisome_Homo sapiens_hsa041460.31059389
132Glycerolipid metabolism_Homo sapiens_hsa005610.29489101
133Pancreatic secretion_Homo sapiens_hsa049720.29196537
134Thyroid hormone synthesis_Homo sapiens_hsa049180.26955983

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