YPEL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1oxygen transport (GO:0015671)6.72129574
2gas transport (GO:0015669)6.26931988
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.87179719
4protoporphyrinogen IX metabolic process (GO:0046501)5.51420863
5vocalization behavior (GO:0071625)5.41677178
6synaptic vesicle docking involved in exocytosis (GO:0016081)5.22795902
7synaptic vesicle exocytosis (GO:0016079)5.22328482
8synaptic vesicle maturation (GO:0016188)5.22073528
9regulation of synaptic vesicle exocytosis (GO:2000300)5.09892825
10protoporphyrinogen IX biosynthetic process (GO:0006782)5.06758798
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.05210785
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.01130818
13glutamate secretion (GO:0014047)4.82819785
14locomotory exploration behavior (GO:0035641)4.79815210
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.72081726
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.70478469
17neuron cell-cell adhesion (GO:0007158)4.66771534
18neuronal action potential propagation (GO:0019227)4.64343619
19regulation of glutamate receptor signaling pathway (GO:1900449)4.55727649
20regulation of synaptic vesicle transport (GO:1902803)4.53565287
21sodium ion export (GO:0071436)4.47349611
22neurotransmitter secretion (GO:0007269)4.43823746
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.37406198
24synaptic transmission, glutamatergic (GO:0035249)4.36558265
25neurotransmitter-gated ion channel clustering (GO:0072578)4.30921802
26cerebellar Purkinje cell differentiation (GO:0021702)4.27189811
27protein localization to synapse (GO:0035418)4.21881515
28hemoglobin metabolic process (GO:0020027)4.14719118
29glutamate receptor signaling pathway (GO:0007215)4.09813229
30neuron-neuron synaptic transmission (GO:0007270)4.07004591
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.00658834
32neuronal ion channel clustering (GO:0045161)3.96429418
33erythrocyte development (GO:0048821)3.94808215
34regulation of neuronal synaptic plasticity (GO:0048168)3.90064928
35synaptic vesicle endocytosis (GO:0048488)3.85943896
36potassium ion homeostasis (GO:0055075)3.79851165
37positive regulation of synapse maturation (GO:0090129)3.74675396
38postsynaptic membrane organization (GO:0001941)3.73498002
39erythrocyte maturation (GO:0043249)3.71738890
40regulation of long-term neuronal synaptic plasticity (GO:0048169)3.71015629
41cerebellar granule cell differentiation (GO:0021707)3.70654643
42exploration behavior (GO:0035640)3.70630386
43porphyrin-containing compound metabolic process (GO:0006778)3.66747464
44gamma-aminobutyric acid transport (GO:0015812)3.66248317
45gamma-aminobutyric acid signaling pathway (GO:0007214)3.65154370
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.64956684
47porphyrin-containing compound biosynthetic process (GO:0006779)3.63449956
48regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.63007455
49presynaptic membrane assembly (GO:0097105)3.59936195
50neurotransmitter transport (GO:0006836)3.59330090
51regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.59193702
52cytoskeletal anchoring at plasma membrane (GO:0007016)3.57177285
53response to insecticide (GO:0017085)3.56181600
54regulation of neurotransmitter secretion (GO:0046928)3.55172351
55cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.54552783
56regulation of ARF protein signal transduction (GO:0032012)3.54052026
57dendritic spine morphogenesis (GO:0060997)3.53253578
58neuromuscular process controlling posture (GO:0050884)3.51567535
59L-amino acid import (GO:0043092)3.51210984
60long-term memory (GO:0007616)3.50491133
61axon ensheathment in central nervous system (GO:0032291)3.50454920
62central nervous system myelination (GO:0022010)3.50454920
63negative regulation of synaptic transmission, GABAergic (GO:0032229)3.49693733
64regulation of postsynaptic membrane potential (GO:0060078)3.48143254
65long-term synaptic potentiation (GO:0060291)3.47893462
66membrane depolarization during action potential (GO:0086010)3.46929274
67neuromuscular process controlling balance (GO:0050885)3.44049016
68positive regulation of membrane potential (GO:0045838)3.43010891
69response to pheromone (GO:0019236)3.38641748
70presynaptic membrane organization (GO:0097090)3.36779148
71tetrapyrrole biosynthetic process (GO:0033014)3.36447905
72startle response (GO:0001964)3.35460535
73glycine transport (GO:0015816)3.28964158
74response to methylmercury (GO:0051597)3.26484577
75regulation of neurotransmitter transport (GO:0051588)3.26207447
76positive regulation of dendritic spine development (GO:0060999)3.24313577
77regulation of synaptic transmission, glutamatergic (GO:0051966)3.23803064
78regulation of neurotransmitter levels (GO:0001505)3.23167130
79layer formation in cerebral cortex (GO:0021819)3.23043846
80regulation of synaptic plasticity (GO:0048167)3.21813468
81G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.21165445
82negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.21146762
83regulation of synapse maturation (GO:0090128)3.19213914
84positive regulation of neurotransmitter transport (GO:0051590)3.18780260
85amino acid import (GO:0043090)3.18349235
86neuromuscular synaptic transmission (GO:0007274)3.18098838
87positive regulation of fibroblast migration (GO:0010763)3.18032148
88cell differentiation in hindbrain (GO:0021533)3.18004547
89membrane depolarization (GO:0051899)3.16963595
90transmission of nerve impulse (GO:0019226)3.16738301
91negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.16419672
92cell communication by electrical coupling (GO:0010644)3.16372986
93positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.15067814
94neuron recognition (GO:0008038)3.12251347
95positive regulation of neurotransmitter secretion (GO:0001956)3.12079199
96regulation of synapse structural plasticity (GO:0051823)3.11800741
97detection of calcium ion (GO:0005513)3.10758161
98regulation of vesicle fusion (GO:0031338)3.09272530
99potassium ion import (GO:0010107)3.08718856
100cellular potassium ion homeostasis (GO:0030007)3.06988950
101innervation (GO:0060384)3.04551792
102auditory behavior (GO:0031223)3.04075996
103activation of protein kinase A activity (GO:0034199)3.02868590
104positive regulation of synaptic transmission, GABAergic (GO:0032230)3.02737642
105positive regulation of synapse assembly (GO:0051965)3.02517326
106membrane hyperpolarization (GO:0060081)3.02006577
107positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.01632721
108regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.00572574
109positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.00086732
110establishment of mitochondrion localization (GO:0051654)2.98679433
111mechanosensory behavior (GO:0007638)2.98429740
112cell migration in hindbrain (GO:0021535)2.98322426
113proline transport (GO:0015824)2.97953228
114synaptic transmission (GO:0007268)2.97376762
115positive regulation of dendritic spine morphogenesis (GO:0061003)2.96306796
116adult walking behavior (GO:0007628)2.95982782
117positive regulation of synaptic transmission (GO:0050806)2.92583627
118axonal fasciculation (GO:0007413)2.92250632
119negative regulation of dendrite morphogenesis (GO:0050774)2.90912416
120actin filament capping (GO:0051693)2.89335576
121regulation of synaptic transmission (GO:0050804)2.86749120
122learning (GO:0007612)2.85096686
123response to auditory stimulus (GO:0010996)2.83173450
124synapse assembly (GO:0007416)2.82776192
125heme biosynthetic process (GO:0006783)2.82705695
126neuromuscular process (GO:0050905)2.82369726
127behavioral response to cocaine (GO:0048148)2.81840460
128regulation of voltage-gated calcium channel activity (GO:1901385)2.75516915
129negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.74917270

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.38330362
2GBX2_23144817_ChIP-Seq_PC3_Human4.07608592
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12056074
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.96552098
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95691619
6GATA1_22025678_ChIP-Seq_K562_Human2.92103055
7REST_21632747_ChIP-Seq_MESCs_Mouse2.84212792
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.56576142
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.53716045
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.53716045
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.49858010
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.47770216
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.45395717
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41878796
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.39331470
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38612796
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36823057
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.35335803
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.35018994
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.30619330
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.30158041
22DROSHA_22980978_ChIP-Seq_HELA_Human2.28765601
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.27901759
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20436657
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.19842367
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.13041209
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.08979123
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92047807
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.91812106
30TAF15_26573619_Chip-Seq_HEK293_Human1.91530142
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.90967843
32* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.88377801
33* GATA2_19941826_ChIP-Seq_K562_Human1.82333844
34KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.79077567
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77081663
36KDM2B_26808549_Chip-Seq_DND41_Human1.72797877
37RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.72220659
38TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.70841345
39GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.70454038
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70210935
41SMAD4_21799915_ChIP-Seq_A2780_Human1.68038272
42CTCF_27219007_Chip-Seq_Bcells_Human1.65943962
43GATA1_26923725_Chip-Seq_HPCs_Mouse1.65313418
44* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65200424
45* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.61333062
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60888975
47* LXR_22292898_ChIP-Seq_THP-1_Human1.59678582
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59632801
49SCL_19346495_ChIP-Seq_HPC-7_Human1.58795705
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57704356
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.48126972
52* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.47488534
53AR_21572438_ChIP-Seq_LNCaP_Human1.46902113
54ZFP281_27345836_Chip-Seq_ESCs_Mouse1.46731607
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43997271
56P68_20966046_ChIP-Seq_HELA_Human1.42918142
57MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.41618229
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40491884
59P300_19829295_ChIP-Seq_ESCs_Human1.38153904
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36518054
61CREB1_26743006_Chip-Seq_LNCaP_Human1.34340815
62SOX2_21211035_ChIP-Seq_LN229_Gbm1.32769857
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.32705330
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32320394
65OCT4_19829295_ChIP-Seq_ESCs_Human1.31284304
66KDM2B_26808549_Chip-Seq_JURKAT_Human1.30840113
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29768110
68STAT3_23295773_ChIP-Seq_U87_Human1.27731815
69* GATA1_19941826_ChIP-Seq_K562_Human1.26440935
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.26117799
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25725059
72RNF2_27304074_Chip-Seq_NSC_Mouse1.24719904
73RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.24678532
74SMC4_20622854_ChIP-Seq_HELA_Human1.23917859
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23886535
76TCF7_22412390_ChIP-Seq_EML_Mouse1.22197455
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22015230
78TET1_21490601_ChIP-Seq_MESCs_Mouse1.21468126
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.21249734
80* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20285293
81AR_25329375_ChIP-Seq_VCAP_Human1.20037985
82RING1B_27294783_Chip-Seq_ESCs_Mouse1.19882032
83NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19543650
84AR_19668381_ChIP-Seq_PC3_Human1.19403045
85* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19181900
86SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18349466
87GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17055351
88CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16004059
89TCF4_23295773_ChIP-Seq_U87_Human1.15924096
90IGF1R_20145208_ChIP-Seq_DFB_Human1.15788451
91* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15661478
92P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14926000
93ZNF274_21170338_ChIP-Seq_K562_Hela1.14540287
94SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13532510
95ELF1_20517297_ChIP-Seq_JURKAT_Human1.12572266
96YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10053128
97VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07726986
98OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05916747
99TP53_20018659_ChIP-ChIP_R1E_Mouse1.05564721
100* KDM2B_26808549_Chip-Seq_K562_Human1.05446549
101* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04868060
102TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04154274
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03313577
104CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02696548
105* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.02197931
106SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01582086
107* GATA1_19941827_ChIP-Seq_MEL_Mouse1.00926696
108SMAD4_21741376_ChIP-Seq_ESCs_Human0.99886854
109WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99203331
110SA1_27219007_Chip-Seq_ERYTHROID_Human0.98637102
111SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96725550
112SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96541452
113RUNX2_22187159_ChIP-Seq_PCA_Human0.95711279
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95699182
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95699182
116RING1B_27294783_Chip-Seq_NPCs_Mouse0.95566284
117MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95546632
118TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95436281
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94981603
120* SOX9_26525672_Chip-Seq_HEART_Mouse0.94328752
121BCOR_27268052_Chip-Seq_Bcells_Human0.94032826
122ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93832285
123SMAD_19615063_ChIP-ChIP_OVARY_Human0.92584329
124SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92143897
125RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92086204
126FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.90190001
127SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90060353
128* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89927960
129NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88823794
130DPY_21335234_ChIP-Seq_ESCs_Mouse0.88596252
131SMAD3_21741376_ChIP-Seq_ESCs_Human0.88415227
132TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88242507
133CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88140574
134ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87871988
135ARNT_22903824_ChIP-Seq_MCF-7_Human0.87534715
136CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.87475347
137OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.87053015
138* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.86775946
139TP53_23651856_ChIP-Seq_MEFs_Mouse0.86468636
140FUS_26573619_Chip-Seq_HEK293_Human0.86014660
141TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85958921
142UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.85672020
143VDR_21846776_ChIP-Seq_THP-1_Human0.85001422
144NANOG_18555785_Chip-Seq_ESCs_Mouse0.84088739
145TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.83709142
146KLF4_19829295_ChIP-Seq_ESCs_Human0.83582452
147ER_23166858_ChIP-Seq_MCF-7_Human0.83008708
148SMAD4_21741376_ChIP-Seq_HESCs_Human0.82845186

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.60569414
2MP0003880_abnormal_central_pattern4.23829258
3MP0003635_abnormal_synaptic_transmissio3.75348253
4MP0009046_muscle_twitch3.29459196
5MP0003656_abnormal_erythrocyte_physiolo3.21754143
6MP0004147_increased_porphyrin_level3.18369894
7MP0009745_abnormal_behavioral_response3.12942412
8MP0004270_analgesia3.10841888
9MP0002063_abnormal_learning/memory/cond2.98610164
10MP0002064_seizures2.98417651
11MP0001968_abnormal_touch/_nociception2.96215782
12MP0002734_abnormal_mechanical_nocicepti2.66502371
13MP0002272_abnormal_nervous_system2.64636840
14MP0002735_abnormal_chemical_nociception2.62557529
15MP0002736_abnormal_nociception_after2.62071459
16MP0002572_abnormal_emotion/affect_behav2.55594630
17MP0005083_abnormal_biliary_tract2.40815090
18MP0003787_abnormal_imprinting2.40374504
19MP0002822_catalepsy2.30022089
20MP0001486_abnormal_startle_reflex2.25816112
21MP0001984_abnormal_olfaction2.24327650
22MP0005646_abnormal_pituitary_gland2.19108818
23MP0009278_abnormal_bone_marrow2.15481777
24MP0005423_abnormal_somatic_nervous2.13538811
25MP0001501_abnormal_sleep_pattern2.11819909
26MP0002067_abnormal_sensory_capabilities2.11327207
27MP0005645_abnormal_hypothalamus_physiol2.09158934
28MP0003122_maternal_imprinting1.98843746
29MP0008569_lethality_at_weaning1.93979288
30MP0006276_abnormal_autonomic_nervous1.90971833
31MP0002184_abnormal_innervation1.89023876
32MP0002733_abnormal_thermal_nociception1.87410956
33MP0001970_abnormal_pain_threshold1.85420592
34MP0003172_abnormal_lysosome_physiology1.84840014
35MP0002557_abnormal_social/conspecific_i1.80936659
36MP0003879_abnormal_hair_cell1.80158093
37MP0001440_abnormal_grooming_behavior1.75202221
38MP0002909_abnormal_adrenal_gland1.71005199
39MP0004811_abnormal_neuron_physiology1.70510742
40MP0005397_hematopoietic_system_phenotyp1.61977370
41MP0001545_abnormal_hematopoietic_system1.61977370
42MP0010386_abnormal_urinary_bladder1.60153462
43MP0009780_abnormal_chondrocyte_physiolo1.57479160
44MP0005386_behavior/neurological_phenoty1.51636173
45MP0004924_abnormal_behavior1.51636173
46MP0000778_abnormal_nervous_system1.49034423
47MP0004858_abnormal_nervous_system1.47794730
48MP0001529_abnormal_vocalization1.46371556
49MP0000955_abnormal_spinal_cord1.43689052
50MP0002882_abnormal_neuron_morphology1.42398348
51MP0004142_abnormal_muscle_tone1.41469021
52MP0005499_abnormal_olfactory_system1.38944480
53MP0005394_taste/olfaction_phenotype1.38944480
54MP0002066_abnormal_motor_capabilities/c1.36720948
55MP0001188_hyperpigmentation1.35096126
56MP0003690_abnormal_glial_cell1.33601261
57MP0001502_abnormal_circadian_rhythm1.25565449
58MP0000920_abnormal_myelination1.23707847
59MP0004130_abnormal_muscle_cell1.23629386
60MP0008872_abnormal_physiological_respon1.15247943
61MP0000015_abnormal_ear_pigmentation1.13836159
62MP0002653_abnormal_ependyma_morphology1.13506420
63MP0005377_hearing/vestibular/ear_phenot1.13392306
64MP0003878_abnormal_ear_physiology1.13392306
65MP0002152_abnormal_brain_morphology1.10148137
66MP0004145_abnormal_muscle_electrophysio1.07771014
67MP0003633_abnormal_nervous_system1.05668338
68MP0000604_amyloidosis1.03727243
69MP0002229_neurodegeneration1.02728677
70MP0001905_abnormal_dopamine_level1.02067836
71MP0003123_paternal_imprinting1.01986527
72MP0002837_dystrophic_cardiac_calcinosis1.00657133
73MP0002638_abnormal_pupillary_reflex0.98808577
74MP0005551_abnormal_eye_electrophysiolog0.98064222
75MP0003631_nervous_system_phenotype0.97639154
76MP0003329_amyloid_beta_deposits0.97280339
77MP0004085_abnormal_heartbeat0.95968078
78MP0002876_abnormal_thyroid_physiology0.95775623
79MP0004742_abnormal_vestibular_system0.95343943
80MP0003121_genomic_imprinting0.93973238
81MP0004885_abnormal_endolymph0.90796761
82MP0000013_abnormal_adipose_tissue0.90482886
83MP0002069_abnormal_eating/drinking_beha0.90458504
84MP0000631_abnormal_neuroendocrine_gland0.89790467
85MP0008789_abnormal_olfactory_epithelium0.88329988
86MP0004043_abnormal_pH_regulation0.88275797
87MP0001963_abnormal_hearing_physiology0.84608569
88MP0002752_abnormal_somatic_nervous0.83452366
89MP0005167_abnormal_blood-brain_barrier0.79756755
90MP0008877_abnormal_DNA_methylation0.78778069
91MP0003283_abnormal_digestive_organ0.78503720
92MP0002751_abnormal_autonomic_nervous0.76941791
93MP0004215_abnormal_myocardial_fiber0.75201291
94MP0003303_peritoneal_inflammation0.73520481
95MP0003632_abnormal_nervous_system0.72285008
96MP0001348_abnormal_lacrimal_gland0.71727293
97MP0005535_abnormal_body_temperature0.65811113
98MP0010769_abnormal_survival0.64749325
99MP0005171_absent_coat_pigmentation0.64449890
100MP0010770_preweaning_lethality0.63721002
101MP0002082_postnatal_lethality0.63721002
102MP0003183_abnormal_peptide_metabolism0.63409701
103MP0001485_abnormal_pinna_reflex0.62815586
104MP0008995_early_reproductive_senescence0.62738078
105MP0010768_mortality/aging0.61993886
106MP0008260_abnormal_autophagy0.61828831
107MP0001986_abnormal_taste_sensitivity0.61725901
108MP0006292_abnormal_olfactory_placode0.61169481
109MP0006072_abnormal_retinal_apoptosis0.60254697
110MP0001664_abnormal_digestion0.60230106
111MP0001177_atelectasis0.58923086
112MP0008874_decreased_physiological_sensi0.58837070
113MP0001299_abnormal_eye_distance/0.57990705
114MP0003861_abnormal_nervous_system0.57023658
115MP0000751_myopathy0.56728719
116MP0003634_abnormal_glial_cell0.55976707
117MP0000026_abnormal_inner_ear0.55365810
118MP0002083_premature_death0.49110773
119MP0005636_abnormal_mineral_homeostasis0.47536527
120MP0002095_abnormal_skin_pigmentation0.45034310

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.49703113
2Febrile seizures (HP:0002373)5.52108653
3Focal seizures (HP:0007359)5.43251279
4Myokymia (HP:0002411)5.41295491
5Poikilocytosis (HP:0004447)5.26659784
6Atonic seizures (HP:0010819)5.25564032
7Abnormality of the heme biosynthetic pathway (HP:0010472)5.05960019
8Epileptic encephalopathy (HP:0200134)5.05343939
9Visual hallucinations (HP:0002367)4.66716291
10Absence seizures (HP:0002121)4.12412028
11Progressive cerebellar ataxia (HP:0002073)4.00224515
12Generalized tonic-clonic seizures (HP:0002069)3.87479844
13Dialeptic seizures (HP:0011146)3.84942371
14Microcytic anemia (HP:0001935)3.57943224
15Reticulocytosis (HP:0001923)3.52364531
16Abnormal hemoglobin (HP:0011902)3.47199856
17Hypochromic microcytic anemia (HP:0004840)3.44948184
18Gaze-evoked nystagmus (HP:0000640)3.39996513
19Hyperventilation (HP:0002883)3.36389586
20Depression (HP:0000716)3.30277473
21Abnormality of reticulocytes (HP:0004312)3.19218662
22Broad-based gait (HP:0002136)3.17493983
23Neurofibrillary tangles (HP:0002185)3.16561140
24Insomnia (HP:0100785)3.15907866
25Acanthocytosis (HP:0001927)3.14776593
26Action tremor (HP:0002345)3.14471139
27Mutism (HP:0002300)3.10761125
28Truncal ataxia (HP:0002078)3.07051404
29Abnormal hair whorl (HP:0010721)3.04609565
30Annular pancreas (HP:0001734)3.02817712
31Obstructive sleep apnea (HP:0002870)3.01046289
32Dysdiadochokinesis (HP:0002075)2.98748140
33Peripheral hypomyelination (HP:0007182)2.94984703
34Anxiety (HP:0000739)2.94419449
35Hypochromic anemia (HP:0001931)2.91808459
36Cholelithiasis (HP:0001081)2.89500253
37Cerebral inclusion bodies (HP:0100314)2.82105752
38Abnormal gallbladder morphology (HP:0012437)2.72467068
39Osteomalacia (HP:0002749)2.67743199
40Impaired vibration sensation in the lower limbs (HP:0002166)2.65140406
41Absent speech (HP:0001344)2.62310995
42Impaired smooth pursuit (HP:0007772)2.60142502
43Postural instability (HP:0002172)2.59873416
44Amblyopia (HP:0000646)2.57901829
45Papilledema (HP:0001085)2.57029755
46Abnormal eating behavior (HP:0100738)2.55529906
47Ankle clonus (HP:0011448)2.50772295
48Neuronal loss in central nervous system (HP:0002529)2.49344885
49Abnormality of the corticospinal tract (HP:0002492)2.48124179
50Hemiparesis (HP:0001269)2.46832842
51Failure to thrive in infancy (HP:0001531)2.46473552
52Epileptiform EEG discharges (HP:0011182)2.45792285
53Poor eye contact (HP:0000817)2.45036023
54Abnormal social behavior (HP:0012433)2.43770079
55Impaired social interactions (HP:0000735)2.43770079
56Dysmetric saccades (HP:0000641)2.42007658
57Dysmetria (HP:0001310)2.41648211
58Gait imbalance (HP:0002141)2.41358454
59Protruding tongue (HP:0010808)2.40447128
60Scanning speech (HP:0002168)2.36152484
61Blue irides (HP:0000635)2.35220895
62EEG with generalized epileptiform discharges (HP:0011198)2.31998384
63Cerebral hypomyelination (HP:0006808)2.29372948
64Status epilepticus (HP:0002133)2.28512856
65Progressive inability to walk (HP:0002505)2.28283929
66Diplopia (HP:0000651)2.26296495
67Abnormality of binocular vision (HP:0011514)2.26296495
68Excessive salivation (HP:0003781)2.25481866
69Drooling (HP:0002307)2.25481866
70Akinesia (HP:0002304)2.23168132
71Congenital primary aphakia (HP:0007707)2.20760849
72Intention tremor (HP:0002080)2.20592203
73Urinary bladder sphincter dysfunction (HP:0002839)2.19846874
74Urinary urgency (HP:0000012)2.19704061
75Polycythemia (HP:0001901)2.19334786
76Hypsarrhythmia (HP:0002521)2.18074974
77Limb dystonia (HP:0002451)2.18038620
78Abnormality of ocular smooth pursuit (HP:0000617)2.17842689
79Ileus (HP:0002595)2.17731442
80Specific learning disability (HP:0001328)2.16536247
81Genetic anticipation (HP:0003743)2.16360167
82Supranuclear gaze palsy (HP:0000605)2.16062490
83Apathy (HP:0000741)2.15550816
84Lower limb muscle weakness (HP:0007340)2.13476785
85Bradykinesia (HP:0002067)2.12807947
86Fetal akinesia sequence (HP:0001989)2.12752998
87Thickened helices (HP:0000391)2.12398272
88Nephrogenic diabetes insipidus (HP:0009806)2.11997490
89Medial flaring of the eyebrow (HP:0010747)2.08459876
90Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.07503133
91Psychosis (HP:0000709)2.07350573
92Abnormality of the aortic arch (HP:0012303)2.06364798
93Abnormality of the lower motor neuron (HP:0002366)2.06169220
94Morphological abnormality of the pyramidal tract (HP:0002062)2.05298136
95Diaphragmatic weakness (HP:0009113)2.01554833
96Hemiplegia (HP:0002301)2.00291196
97Abnormality of the fingertips (HP:0001211)2.00159192
98Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.99968175
99Cholecystitis (HP:0001082)1.99579670
100Abnormal gallbladder physiology (HP:0012438)1.99579670
101Agitation (HP:0000713)1.97898356
102Cortical visual impairment (HP:0100704)1.96982457
103Narrow nasal bridge (HP:0000446)1.95295582
104Diminished motivation (HP:0000745)1.94431235
105Pheochromocytoma (HP:0002666)1.94301787
106Polyphagia (HP:0002591)1.93400751
107Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.93243938
108Delusions (HP:0000746)1.91547430
109Confusion (HP:0001289)1.90655910
110Spastic gait (HP:0002064)1.90597896
111Abnormality of the gallbladder (HP:0005264)1.89948661
112Spinal canal stenosis (HP:0003416)1.89931766
113Clonus (HP:0002169)1.88674114
114Torticollis (HP:0000473)1.88485059
115Incomplete penetrance (HP:0003829)1.88416174
116Rigidity (HP:0002063)1.86232547
117Impaired vibratory sensation (HP:0002495)1.86210776
118Abnormality of the labia minora (HP:0012880)1.86076955
119Rapidly progressive (HP:0003678)1.85434241
120Hypothermia (HP:0002045)1.85065854
121Paralysis (HP:0003470)1.84542275
122Focal dystonia (HP:0004373)1.84415978
123Inability to walk (HP:0002540)1.79545376
124Thyroid-stimulating hormone excess (HP:0002925)1.78674412
125Hyperbilirubinemia (HP:0002904)1.78634703
126Hypoventilation (HP:0002791)1.76154416
127Spastic paraplegia (HP:0001258)1.75226872
128Turricephaly (HP:0000262)1.74769795
129Genital tract atresia (HP:0001827)1.73893214
130Neuroendocrine neoplasm (HP:0100634)1.72214818
131Hyperthyroidism (HP:0000836)1.70667688
132Gait ataxia (HP:0002066)1.68155491
133Stereotypic behavior (HP:0000733)1.67721032
134Sleep apnea (HP:0010535)1.67341254
135Vaginal atresia (HP:0000148)1.67152424

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.08294106
2CASK4.01325380
3EPHA43.10101975
4MAP3K42.93659862
5MAP2K72.87006293
6PRPF4B2.81609170
7DAPK22.65070328
8MAP3K92.50342396
9MINK12.21128972
10AKT32.08176189
11MAP3K121.99598396
12MARK11.96851415
13MAP3K111.82398045
14GRK51.80858467
15SGK21.78828090
16PAK61.76461014
17PLK21.74495662
18SGK4941.72766489
19SGK2231.72766489
20MAP2K41.71740817
21NTRK21.69815285
22CAMK1D1.68893130
23MAPK131.66909204
24CAMKK21.63113035
25RIPK11.61566805
26DAPK11.57941757
27MARK21.48720051
28CDK191.47612452
29CAMKK11.39740937
30SGK31.38622357
31CDK51.38583477
32UHMK11.37310005
33PRKD31.33740071
34KSR11.31126455
35PRKCG1.31034478
36DYRK31.23582769
37BRSK11.17511425
38MAPK121.16542236
39SIK31.12595176
40TNIK1.10067769
41KSR21.05596655
42LATS21.04599847
43DYRK1B1.03867154
44BRAF1.02280967
45PINK11.01861171
46BMX1.00251560
47WNK10.99664751
48TAOK10.98387566
49NTRK10.97250947
50ARAF0.96210409
51BRD40.96011768
52WNK30.94569031
53CDC42BPA0.94045396
54STK380.93970921
55PKN10.93684108
56SGK10.93131036
57PRKCH0.92106620
58CDK180.90858022
59CAMK2A0.89092811
60ICK0.88862220
61CDK120.86923628
62DYRK1A0.85528168
63CDK150.84586320
64TNK20.84031529
65DYRK20.83265118
66CAMK2B0.81867044
67SIK20.80097353
68CDK140.79008248
69MAP3K20.78824088
70CCNB10.75958923
71ADRBK20.75146967
72CDK11A0.71698169
73MAP2K30.71213166
74PIM10.71180663
75OXSR10.69641496
76CAMK10.69190159
77PHKG10.69044114
78PHKG20.69044114
79TLK10.68136205
80BMPR20.67604150
81MAPK100.64103941
82CDK30.60651856
83MAP3K10.60178776
84STK110.59912203
85RIPK40.59321065
86RPS6KA30.58025816
87GRK70.56182378
88PRKCZ0.55911883
89PTK2B0.54960697
90RPS6KA50.54422175
91RPS6KL10.54240222
92RPS6KC10.54240222
93FES0.53217776
94EIF2AK10.52800866
95MAP2K10.52666894
96PRKCE0.52657291
97INSRR0.52148161
98CAMK1G0.51104696
99ERBB30.49951166
100NEK60.48943434
101PNCK0.48489050
102PRKAA10.48483240
103RPS6KA60.48387678
104CAMK40.47925477
105RPS6KA20.47863431
106ERBB20.47410896
107RET0.47155283
108HIPK20.47108100
109MAPK80.44808858
110CAMK2G0.44502720
111CSNK1G20.42914993
112TYRO30.42898090
113TAOK20.42704077
114CAMK2D0.42485433
115GSK3B0.41986846
116MAPK110.41845177
117PRKCB0.39875395
118CSNK1A10.39798085
119TSSK60.39753998
120RAF10.39197703
121MAPKAPK50.38988925
122DAPK30.38567048
123ZAK0.38085892
124PDPK10.36919996
125JAK20.36648999
126PRKACA0.35948340
127PRKD20.35472277
128PDK10.34739944
129PAK30.34586545
130NME10.34338824

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.10640610
2Synaptic vesicle cycle_Homo sapiens_hsa047213.86847275
3Olfactory transduction_Homo sapiens_hsa047403.04214740
4GABAergic synapse_Homo sapiens_hsa047272.74649981
5Collecting duct acid secretion_Homo sapiens_hsa049662.73683027
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.71715079
7Circadian entrainment_Homo sapiens_hsa047132.65652651
8Morphine addiction_Homo sapiens_hsa050322.58339497
9Long-term potentiation_Homo sapiens_hsa047202.56343859
10Glutamatergic synapse_Homo sapiens_hsa047242.48761554
11Amphetamine addiction_Homo sapiens_hsa050312.41724511
12Insulin secretion_Homo sapiens_hsa049112.26609808
13Taste transduction_Homo sapiens_hsa047422.14726835
14Dopaminergic synapse_Homo sapiens_hsa047282.06198382
15Salivary secretion_Homo sapiens_hsa049701.93591400
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.92248522
17Cholinergic synapse_Homo sapiens_hsa047251.74877365
18Serotonergic synapse_Homo sapiens_hsa047261.64116838
19Alcoholism_Homo sapiens_hsa050341.61160622
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.57463910
21Long-term depression_Homo sapiens_hsa047301.56285459
22Cocaine addiction_Homo sapiens_hsa050301.53478088
23Gastric acid secretion_Homo sapiens_hsa049711.50465777
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50341100
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.47326638
26Calcium signaling pathway_Homo sapiens_hsa040201.45635768
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.39882950
28Renin secretion_Homo sapiens_hsa049241.36813220
29Oxytocin signaling pathway_Homo sapiens_hsa049211.34329675
30Vibrio cholerae infection_Homo sapiens_hsa051101.32471663
31Type II diabetes mellitus_Homo sapiens_hsa049301.28889160
32Gap junction_Homo sapiens_hsa045401.20441476
33GnRH signaling pathway_Homo sapiens_hsa049121.19802312
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17133049
35Glioma_Homo sapiens_hsa052141.14905841
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14209036
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.14013461
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13413039
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12830046
40cAMP signaling pathway_Homo sapiens_hsa040241.11019528
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08693734
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06608666
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01873172
44ErbB signaling pathway_Homo sapiens_hsa040120.99550495
45Phototransduction_Homo sapiens_hsa047440.97303207
46Estrogen signaling pathway_Homo sapiens_hsa049150.96998077
47Dorso-ventral axis formation_Homo sapiens_hsa043200.95964881
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95553566
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89741902
50Axon guidance_Homo sapiens_hsa043600.88627334
51Systemic lupus erythematosus_Homo sapiens_hsa053220.83826007
52Cardiac muscle contraction_Homo sapiens_hsa042600.81764804
53Melanogenesis_Homo sapiens_hsa049160.80686825
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80187013
55VEGF signaling pathway_Homo sapiens_hsa043700.79637401
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79558808
57Oocyte meiosis_Homo sapiens_hsa041140.79180942
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.77244274
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75351703
60Circadian rhythm_Homo sapiens_hsa047100.75018845
61Pancreatic secretion_Homo sapiens_hsa049720.73388092
62Vitamin B6 metabolism_Homo sapiens_hsa007500.72149540
63MAPK signaling pathway_Homo sapiens_hsa040100.71283718
64Malaria_Homo sapiens_hsa051440.69543333
65Prion diseases_Homo sapiens_hsa050200.68979830
66Endometrial cancer_Homo sapiens_hsa052130.68971475
67Thyroid hormone synthesis_Homo sapiens_hsa049180.68629466
68Non-small cell lung cancer_Homo sapiens_hsa052230.65757259
69Choline metabolism in cancer_Homo sapiens_hsa052310.61809599
70Glucagon signaling pathway_Homo sapiens_hsa049220.60111482
71Type I diabetes mellitus_Homo sapiens_hsa049400.59887763
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58680610
73AMPK signaling pathway_Homo sapiens_hsa041520.58576854
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.58198135
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56507749
76ABC transporters_Homo sapiens_hsa020100.56271946
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.55394745
78Inositol phosphate metabolism_Homo sapiens_hsa005620.54269916
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54102334
80Regulation of autophagy_Homo sapiens_hsa041400.53015265
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.52948809
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.52750643
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52494632
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.52409793
85Dilated cardiomyopathy_Homo sapiens_hsa054140.52019563
86Mineral absorption_Homo sapiens_hsa049780.50719227
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49550570
88African trypanosomiasis_Homo sapiens_hsa051430.47906332
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47643494
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47216803
91Ras signaling pathway_Homo sapiens_hsa040140.46980026
92Insulin signaling pathway_Homo sapiens_hsa049100.44692717
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44622883
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44064996
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42747291
96Alzheimers disease_Homo sapiens_hsa050100.42604115
97Oxidative phosphorylation_Homo sapiens_hsa001900.42009357
98HIF-1 signaling pathway_Homo sapiens_hsa040660.41108760
99Melanoma_Homo sapiens_hsa052180.38522317
100Wnt signaling pathway_Homo sapiens_hsa043100.37053902
101mTOR signaling pathway_Homo sapiens_hsa041500.36132651
102Chronic myeloid leukemia_Homo sapiens_hsa052200.36031258
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.35668927
104Lysosome_Homo sapiens_hsa041420.34715930
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34166600
106Endocytosis_Homo sapiens_hsa041440.32821930
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29930731
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29011100
109Rheumatoid arthritis_Homo sapiens_hsa053230.28680767
110Rap1 signaling pathway_Homo sapiens_hsa040150.27442804
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.26899913
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25583267
113Renal cell carcinoma_Homo sapiens_hsa052110.25582535
114Prolactin signaling pathway_Homo sapiens_hsa049170.25569652
115FoxO signaling pathway_Homo sapiens_hsa040680.25342288
116Maturity onset diabetes of the young_Homo sapiens_hsa049500.24635849
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22731355
118Bile secretion_Homo sapiens_hsa049760.22446418

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