YPEL5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of dendrite morphogenesis (GO:0050774)4.93610024
2positive regulation of mitochondrial fission (GO:0090141)4.87931307
3negative regulation of homotypic cell-cell adhesion (GO:0034111)4.35223970
4neutrophil activation (GO:0042119)4.01861033
5transferrin transport (GO:0033572)4.01127539
6phagosome maturation (GO:0090382)3.95383335
7inositol phosphate catabolic process (GO:0071545)3.91479419
8positive regulation of cellular amide metabolic process (GO:0034250)3.80745979
9ferric iron transport (GO:0015682)3.76882069
10trivalent inorganic cation transport (GO:0072512)3.76882069
11protein neddylation (GO:0045116)3.74485067
12negative regulation of mast cell activation (GO:0033004)3.73711447
13negative regulation of cell killing (GO:0031342)3.57134908
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.57134908
15granulocyte activation (GO:0036230)3.56695753
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.55507138
17tolerance induction (GO:0002507)3.52593122
18myoblast migration (GO:0051451)3.52278891
19signal peptide processing (GO:0006465)3.41833818
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.39097920
21negative regulation of dendrite development (GO:2000171)3.36251948
22neutrophil activation involved in immune response (GO:0002283)3.32353790
23ER overload response (GO:0006983)3.31867137
24regulation of mitochondrial fission (GO:0090140)3.31588274
25negative regulation of T-helper cell differentiation (GO:0045623)3.30815311
26negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.30815311
27positive regulation of gamma-delta T cell activation (GO:0046645)3.30068071
28thrombin receptor signaling pathway (GO:0070493)3.28384660
29regulation of B cell receptor signaling pathway (GO:0050855)3.22844942
30positive regulation of granulocyte differentiation (GO:0030854)3.22825404
31serotonin receptor signaling pathway (GO:0007210)3.17872158
32negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.16765599
33protein deneddylation (GO:0000338)3.13490664
34regulation of regulatory T cell differentiation (GO:0045589)3.12289595
35production of molecular mediator involved in inflammatory response (GO:0002532)3.12162727
36negative regulation of synaptic transmission, GABAergic (GO:0032229)3.09038310
37histamine secretion (GO:0001821)3.08533359
38regulation of platelet aggregation (GO:0090330)2.99009614
39mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.95824735
40positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.95824735
41chaperone-mediated protein transport (GO:0072321)2.95550819
42activated T cell proliferation (GO:0050798)2.93328467
43positive regulation of mast cell activation (GO:0033005)2.91658944
44mast cell activation (GO:0045576)2.91448722
45phosphorylated carbohydrate dephosphorylation (GO:0046838)2.91429808
46inositol phosphate dephosphorylation (GO:0046855)2.91429808
47cullin deneddylation (GO:0010388)2.89317528
48regulation of memory T cell differentiation (GO:0043380)2.88251616
49peripheral nervous system neuron development (GO:0048935)2.87532337
50regulation of cAMP-dependent protein kinase activity (GO:2000479)2.86697102
51cellular response to interleukin-15 (GO:0071350)2.83750860
52leukocyte degranulation (GO:0043299)2.82245651
53superoxide anion generation (GO:0042554)2.81851678
54presynaptic membrane assembly (GO:0097105)2.81712948
55energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.80422466
56ATP hydrolysis coupled proton transport (GO:0015991)2.80422466
57regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.76305966
58regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.76305966
59regulation of synaptic vesicle transport (GO:1902803)2.75472451
60negative regulation of systemic arterial blood pressure (GO:0003085)2.74430049
61regulation of mast cell activation (GO:0033003)2.72815283
62negative T cell selection (GO:0043383)2.72128550
63regulation of hexokinase activity (GO:1903299)2.69168946
64regulation of glucokinase activity (GO:0033131)2.69168946
65positive regulation of endothelial cell differentiation (GO:0045603)2.69016882
66purinergic nucleotide receptor signaling pathway (GO:0035590)2.68277556
67cellular response to gamma radiation (GO:0071480)2.68275361
68positive regulation of B cell differentiation (GO:0045579)2.67527821
69negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.66009167
70regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.63485855
71iron ion transport (GO:0006826)2.61956301
72G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.61689186
73intracellular pH reduction (GO:0051452)2.61193811
74regulation of synaptic vesicle exocytosis (GO:2000300)2.60992882
75regulation of female gonad development (GO:2000194)2.60241567
76regulation of gamma-delta T cell activation (GO:0046643)2.59833408
77neurotransmitter-gated ion channel clustering (GO:0072578)2.59685244
78regulation of meiosis I (GO:0060631)2.59650516
79myeloid cell activation involved in immune response (GO:0002275)2.59077889
80viral protein processing (GO:0019082)2.58979222
81hydrogen peroxide biosynthetic process (GO:0050665)2.58423921
82response to interleukin-15 (GO:0070672)2.56979911
83Arp2/3 complex-mediated actin nucleation (GO:0034314)2.55837514
84cellular extravasation (GO:0045123)2.55759601
85negative thymic T cell selection (GO:0045060)2.55143076
86RNA destabilization (GO:0050779)2.54807114
87positive regulation of steroid hormone secretion (GO:2000833)2.53878112
88negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.53769548
89regulation of gamma-delta T cell differentiation (GO:0045586)2.53380283
90regulation of RIG-I signaling pathway (GO:0039535)2.51689557
91leukocyte migration involved in inflammatory response (GO:0002523)2.51486482
92interferon-gamma production (GO:0032609)2.49317096
93negative regulation of signal transduction by p53 class mediator (GO:1901797)2.48971015
94adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.48805280
95dendritic cell migration (GO:0036336)2.48227894
96regulation of alpha-beta T cell proliferation (GO:0046640)2.47351988
97positive regulation of monocyte chemotaxis (GO:0090026)2.46979492
98eosinophil chemotaxis (GO:0048245)2.46813360
99regulation of T cell receptor signaling pathway (GO:0050856)2.46241291
100negative regulation of membrane potential (GO:0045837)2.45976796
101positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.45689336
102piRNA metabolic process (GO:0034587)2.45460805
103autophagic vacuole fusion (GO:0000046)2.44909741
104negative regulation of T cell mediated immunity (GO:0002710)2.43526766
105organelle membrane fusion (GO:0090174)2.42913418
106microglial cell activation (GO:0001774)2.41923684
107regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.41863040
108positive regulation of DNA recombination (GO:0045911)2.41782416
109presynaptic membrane organization (GO:0097090)2.41359194
110immunoglobulin mediated immune response (GO:0016064)2.40230092
111polyol catabolic process (GO:0046174)2.39969487
112pH reduction (GO:0045851)2.38876458
113protein-cofactor linkage (GO:0018065)2.38412839
114negative regulation of lymphocyte mediated immunity (GO:0002707)2.37835228
115protein localization to cilium (GO:0061512)2.37762277
116regulation of platelet activation (GO:0010543)2.37596555
117negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.37394409
118negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.36852288
119relaxation of smooth muscle (GO:0044557)2.35591467
120positive regulation of interleukin-1 beta secretion (GO:0050718)2.35472311
121antigen receptor-mediated signaling pathway (GO:0050851)2.35309344
122actin nucleation (GO:0045010)2.35071517
123positive regulation of alpha-beta T cell proliferation (GO:0046641)2.34397174
124positive regulation of mitochondrial membrane permeability (GO:0035794)2.34198450
125regulation of mast cell degranulation (GO:0043304)2.33240208
126regulation of establishment of cell polarity (GO:2000114)2.33236858
127megakaryocyte development (GO:0035855)2.33228370
128mitochondrial calcium ion homeostasis (GO:0051560)2.32592352
129maturation of 5.8S rRNA (GO:0000460)2.32178993
130lipoxygenase pathway (GO:0019372)2.31391798
131sequestering of actin monomers (GO:0042989)2.30875147
132regulation of mast cell activation involved in immune response (GO:0033006)2.30758929
133cytochrome complex assembly (GO:0017004)2.30514532
134regulation of T-helper 1 cell differentiation (GO:0045625)2.29559183
135histamine transport (GO:0051608)2.29062025
136positive regulation of mast cell degranulation (GO:0043306)2.28920215
137positive regulation of mast cell activation involved in immune response (GO:0033008)2.28920215
138striatum development (GO:0021756)2.28172228
139response to hyperoxia (GO:0055093)2.26677277
140response to increased oxygen levels (GO:0036296)2.26677277
141multicellular organism reproduction (GO:0032504)2.26297290
142neutrophil mediated immunity (GO:0002446)2.26023621
143negative regulation of alpha-beta T cell differentiation (GO:0046639)2.26022306
144regulation of homotypic cell-cell adhesion (GO:0034110)2.25997300
145positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.25563612
146regulation of interleukin-17 production (GO:0032660)2.25318727
147deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.25093540
148positive regulation of humoral immune response (GO:0002922)2.24876367
149negative regulation of interleukin-17 production (GO:0032700)2.24857343
150reactive oxygen species biosynthetic process (GO:1903409)2.24851425
151negative regulation of glycoprotein biosynthetic process (GO:0010561)2.24666766
152sleep (GO:0030431)2.24197929
153negative regulation of adaptive immune response (GO:0002820)2.24014981
154positive regulation of interleukin-1 secretion (GO:0050716)2.23877735
155dendritic cell chemotaxis (GO:0002407)2.23587328
156regulation of B cell differentiation (GO:0045577)2.23338534
157platelet dense granule organization (GO:0060155)2.23227756
158myeloid leukocyte mediated immunity (GO:0002444)2.23151682
159regulation of interleukin-1 beta secretion (GO:0050706)2.22971489
160T cell receptor signaling pathway (GO:0050852)2.22735963
161regulation of cell maturation (GO:1903429)2.22196335
162protein complex biogenesis (GO:0070271)2.22165687
163vesicle fusion (GO:0006906)2.22119712
164regulation of germinal center formation (GO:0002634)2.21884384
165negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.21277563
166neuronal action potential propagation (GO:0019227)2.20732672
167negative regulation of alpha-beta T cell activation (GO:0046636)2.20659751
168regulation of amino acid transport (GO:0051955)2.20386477
169protein K11-linked deubiquitination (GO:0035871)2.19966843
170glycosphingolipid catabolic process (GO:0046479)2.19963500
171positive regulation of isotype switching (GO:0045830)2.19867157
172negative regulation of exocytosis (GO:0045920)2.19740736
173retinal cone cell development (GO:0046549)2.19378180
174regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.18564222
175antigen processing and presentation of endogenous antigen (GO:0019883)2.17707376
176regulation of activation of Janus kinase activity (GO:0010533)2.17037089
177positive T cell selection (GO:0043368)2.16913073
178positive regulation of B cell mediated immunity (GO:0002714)2.16892366
179positive regulation of immunoglobulin mediated immune response (GO:0002891)2.16892366
180negative regulation of B cell activation (GO:0050869)2.16789282
181regulation of female receptivity (GO:0045924)2.15880694
1822-deoxyribonucleotide biosynthetic process (GO:0009265)2.15576603
183deoxyribose phosphate biosynthetic process (GO:0046385)2.15576603
184positive regulation of toll-like receptor signaling pathway (GO:0034123)2.15030501
185B cell mediated immunity (GO:0019724)2.14738682
186regulation of DNA methylation (GO:0044030)2.14291210
187respiratory burst (GO:0045730)2.13127999
188neuronal action potential (GO:0019228)2.12215622
189regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.12201415
190negative regulation of cation channel activity (GO:2001258)2.11590278
191regulation of fever generation (GO:0031620)2.10510140
192eosinophil migration (GO:0072677)2.10326368

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.73452625
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.71591093
3* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.52681143
4GBX2_23144817_ChIP-Seq_PC3_Human3.33769183
5SMAD_19615063_ChIP-ChIP_OVARY_Human3.11394131
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.98471942
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.92557579
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.89055805
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.68102305
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.66936862
11RUNX_20019798_ChIP-Seq_JUKART_Human2.53819672
12TAF15_26573619_Chip-Seq_HEK293_Human2.46799847
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.43762188
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.24365669
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.19517710
16* P300_19829295_ChIP-Seq_ESCs_Human2.14299790
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.05093969
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.96080173
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.94788146
20IGF1R_20145208_ChIP-Seq_DFB_Human1.93329159
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.92938090
22LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.88624580
23SMAD4_21799915_ChIP-Seq_A2780_Human1.82835608
24IRF8_27001747_Chip-Seq_BMDM_Mouse1.82335592
25* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.81611006
26PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.78982916
27* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.77615220
28NANOG_18555785_Chip-Seq_ESCs_Mouse1.75711864
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.74192241
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.72959359
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.72492932
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.71381720
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.70538579
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69631670
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66541067
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.65673192
37SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.65365224
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.64723510
39VDR_22108803_ChIP-Seq_LS180_Human1.63996679
40FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.62991592
41TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.62429497
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62179493
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61860228
44STAT3_18555785_Chip-Seq_ESCs_Mouse1.61298385
45MYB_26560356_Chip-Seq_TH2_Human1.61239799
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.60296105
47E2F1_18555785_Chip-Seq_ESCs_Mouse1.59665357
48RNF2_27304074_Chip-Seq_NSC_Mouse1.58310074
49* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.55108909
50* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.55108909
51P53_22387025_ChIP-Seq_ESCs_Mouse1.54724648
52CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54649380
53EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.54242497
54ER_23166858_ChIP-Seq_MCF-7_Human1.52501006
55KAP1_22055183_ChIP-Seq_ESCs_Mouse1.51915428
56SUZ12_18555785_Chip-Seq_ESCs_Mouse1.51605429
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.49787586
58VDR_24787735_ChIP-Seq_THP-1_Human1.49744361
59AR_25329375_ChIP-Seq_VCAP_Human1.48098742
60SCL_19346495_ChIP-Seq_HPC-7_Human1.46962027
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46928528
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.46412520
63NMYC_18555785_Chip-Seq_ESCs_Mouse1.45555147
64* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44995922
65CMYC_18555785_Chip-Seq_ESCs_Mouse1.44444477
66MYB_21317192_ChIP-Seq_ERMYB_Mouse1.42824698
67GATA2_21666600_ChIP-Seq_HMVEC_Human1.41290926
68* GATA3_26560356_Chip-Seq_TH2_Human1.40606631
69GATA3_27048872_Chip-Seq_THYMUS_Human1.40397741
70FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39638465
71* JUN_21703547_ChIP-Seq_K562_Human1.39180737
72SOX2_18555785_Chip-Seq_ESCs_Mouse1.39081418
73EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.37846363
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37686491
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.37532147
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33720921
77EWS_26573619_Chip-Seq_HEK293_Human1.33613087
78RUNX1_27457419_Chip-Seq_LIVER_Mouse1.32719563
79STAT3_23295773_ChIP-Seq_U87_Human1.32112731
80* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30069727
81GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29599698
82P300_18555785_Chip-Seq_ESCs_Mouse1.29248735
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24754800
84RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24732839
85GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23862935
86* TAL1_26923725_Chip-Seq_HPCs_Mouse1.23689558
87* SOX2_19829295_ChIP-Seq_ESCs_Human1.23565286
88* NANOG_19829295_ChIP-Seq_ESCs_Human1.23565286
89SMRT_27268052_Chip-Seq_Bcells_Human1.21226093
90SMAD1_18555785_Chip-Seq_ESCs_Mouse1.18182424
91SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.17548838
92KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.17318385
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15452487
94PU1_27457419_Chip-Seq_LIVER_Mouse1.15328084
95OCT4_18555785_Chip-Seq_ESCs_Mouse1.14957640
96LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14763468
97* PRDM14_20953172_ChIP-Seq_ESCs_Human1.13982897
98CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13814161
99RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.13287980
100STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12632069
101CRX_20693478_ChIP-Seq_RETINA_Mouse1.11343081
102* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10954359
103* KDM2B_26808549_Chip-Seq_REH_Human1.10939510
104FUS_26573619_Chip-Seq_HEK293_Human1.10900729
105* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10742591
106CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09909012
107* RUNX2_22187159_ChIP-Seq_PCA_Human1.09884749
108CTCF_18555785_Chip-Seq_ESCs_Mouse1.09794038
109KLF4_18555785_Chip-Seq_ESCs_Mouse1.08785065
110TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08576877
111ZFX_18555785_Chip-Seq_ESCs_Mouse1.08428770
112MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08326629
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07273762
114KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.06784282
115CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06310197
116SALL4_22934838_ChIP-ChIP_CD34+_Human1.06236847
117SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03990250
118ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03516333
119FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01803000
120* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00989085
121STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00975288
122SRF_21415370_ChIP-Seq_HL-1_Mouse0.99421033
123* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98313109
124* CBP_20019798_ChIP-Seq_JUKART_Human0.98313109
125TP53_18474530_ChIP-ChIP_U2OS_Human0.97909743
126SMAD3_21741376_ChIP-Seq_EPCs_Human0.97710444
127TCF4_23295773_ChIP-Seq_U87_Human0.97471833
128MYB_26560356_Chip-Seq_TH1_Human0.97468481
129ZNF274_21170338_ChIP-Seq_K562_Hela0.97468001
130ESRRB_18555785_Chip-Seq_ESCs_Mouse0.97021867
131MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96953567
132CJUN_26792858_Chip-Seq_BT549_Human0.96425990
133CBX2_27304074_Chip-Seq_ESCs_Mouse0.96217832
134EZH2_22144423_ChIP-Seq_EOC_Human0.95655675
135OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94712603
136BCAT_22108803_ChIP-Seq_LS180_Human0.94666650
137SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.94238684
138FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94156945
139EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.93988599
140RXR_22108803_ChIP-Seq_LS180_Human0.93678320
141FLI1_21867929_ChIP-Seq_TH2_Mouse0.93601219
142AHR_22903824_ChIP-Seq_MCF-7_Human0.93230713
143SPI1_23127762_ChIP-Seq_K562_Human0.92206751
144GATA2_19941826_ChIP-Seq_K562_Human0.91241789
145SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.90688691
146* CDX2_22108803_ChIP-Seq_LS180_Human0.90442944
147FOXO3_23340844_ChIP-Seq_DLD1_Human0.89297395
148SPI1_23547873_ChIP-Seq_NB4_Human0.88550905

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity5.12692643
2MP0005464_abnormal_platelet_physiology3.76931825
3MP0002876_abnormal_thyroid_physiology3.25781690
4MP0010386_abnormal_urinary_bladder3.03471263
5MP0005646_abnormal_pituitary_gland2.85584609
6MP0002735_abnormal_chemical_nociception2.83757911
7MP0003880_abnormal_central_pattern2.75086779
8MP0006276_abnormal_autonomic_nervous2.64450709
9MP0000465_gastrointestinal_hemorrhage2.60580670
10MP0003787_abnormal_imprinting2.55473715
11MP0001968_abnormal_touch/_nociception2.48786646
12MP0002736_abnormal_nociception_after2.47845532
13MP0001984_abnormal_olfaction2.45347262
14MP0009697_abnormal_copulation2.42490622
15MP0004270_analgesia2.36748919
16MP0003183_abnormal_peptide_metabolism2.30414341
17MP0008004_abnormal_stomach_pH2.29413307
18MP0001905_abnormal_dopamine_level2.23696479
19MP0001800_abnormal_humoral_immune2.22395916
20MP0002734_abnormal_mechanical_nocicepti2.20500337
21MP0004782_abnormal_surfactant_physiolog2.20132934
22MP0008260_abnormal_autophagy2.20066152
23MP0003303_peritoneal_inflammation2.08117029
24MP0001835_abnormal_antigen_presentation2.05828127
25MP0002877_abnormal_melanocyte_morpholog2.03055681
26MP0001188_hyperpigmentation2.02026444
27MP0002148_abnormal_hypersensitivity_rea2.01478230
28MP0003724_increased_susceptibility_to1.98096243
29MP0002163_abnormal_gland_morphology1.96348731
30MP0000685_abnormal_immune_system1.90223011
31MP0008877_abnormal_DNA_methylation1.88515553
32MP0002420_abnormal_adaptive_immunity1.87625387
33MP0001819_abnormal_immune_cell1.85566959
34MP0003718_maternal_effect1.83830386
35MP0006054_spinal_hemorrhage1.81477119
36MP0005310_abnormal_salivary_gland1.73337032
37MP0002277_abnormal_respiratory_mucosa1.70587934
38MP0001542_abnormal_bone_strength1.69239116
39MP0003763_abnormal_thymus_physiology1.68738431
40MP0009745_abnormal_behavioral_response1.66511117
41MP0003828_pulmonary_edema1.65082476
42MP0009046_muscle_twitch1.62155591
43MP0010155_abnormal_intestine_physiology1.57976922
44MP0001501_abnormal_sleep_pattern1.55583830
45MP0002138_abnormal_hepatobiliary_system1.54866744
46MP0009785_altered_susceptibility_to1.54225077
47MP0003195_calcinosis1.54115341
48MP0005171_absent_coat_pigmentation1.53698362
49MP0002398_abnormal_bone_marrow1.51336024
50MP0005379_endocrine/exocrine_gland_phen1.50658757
51MP0001529_abnormal_vocalization1.50569483
52MP0002638_abnormal_pupillary_reflex1.49264904
53MP0002009_preneoplasia1.48111377
54MP0002063_abnormal_learning/memory/cond1.47431317
55MP0000716_abnormal_immune_system1.37862460
56MP0005410_abnormal_fertilization1.37476345
57MP0001845_abnormal_inflammatory_respons1.37340764
58MP0002572_abnormal_emotion/affect_behav1.36052716
59MP0003635_abnormal_synaptic_transmissio1.35328349
60MP0001851_eye_inflammation1.32200694
61MP0000689_abnormal_spleen_morphology1.32162938
62MP0002419_abnormal_innate_immunity1.31597554
63MP0001970_abnormal_pain_threshold1.30702996
64MP0005408_hypopigmentation1.30603863
65MP0003186_abnormal_redox_activity1.30563734
66MP0002405_respiratory_system_inflammati1.29109915
67MP0004947_skin_inflammation1.28364559
68MP0002064_seizures1.26927964
69MP0003866_abnormal_defecation1.26919484
70MP0002733_abnormal_thermal_nociception1.26128612
71MP0002132_abnormal_respiratory_system1.26047126
72MP0005671_abnormal_response_to1.25779020
73MP0004859_abnormal_synaptic_plasticity1.25655694
74MP0002272_abnormal_nervous_system1.25645194
75MP0000372_irregular_coat_pigmentation1.23803173
76MP0001502_abnormal_circadian_rhythm1.23721885
77MP0005000_abnormal_immune_tolerance1.23196127
78MP0002102_abnormal_ear_morphology1.22571657
79MP0000015_abnormal_ear_pigmentation1.18363025
80MP0002067_abnormal_sensory_capabilities1.17567469
81MP0008995_early_reproductive_senescence1.16382057
82MP0003656_abnormal_erythrocyte_physiolo1.11777452
83MP0002722_abnormal_immune_system1.11427160
84MP0004484_altered_response_of1.09972503
85MP0003300_gastrointestinal_ulcer1.09489000
86MP0005451_abnormal_body_composition1.08808295
87MP0001440_abnormal_grooming_behavior1.07861561
88MP0005645_abnormal_hypothalamus_physiol1.04257909
89MP0001853_heart_inflammation1.04249825
90MP0002166_altered_tumor_susceptibility1.03134806
91MP0001919_abnormal_reproductive_system1.02445470
92MP0002429_abnormal_blood_cell1.02104883
93MP0001545_abnormal_hematopoietic_system1.01077499
94MP0005397_hematopoietic_system_phenotyp1.01077499
95MP0008872_abnormal_physiological_respon0.97985466
96MP0003436_decreased_susceptibility_to0.97662364
97MP0003646_muscle_fatigue0.97170568
98MP0001119_abnormal_female_reproductive0.96236728
99MP0003879_abnormal_hair_cell0.96148617
100MP0005535_abnormal_body_temperature0.96073231
101MP0000538_abnormal_urinary_bladder0.95678710
102MP0004924_abnormal_behavior0.95045277
103MP0005386_behavior/neurological_phenoty0.95045277
104MP0004883_abnormal_blood_vessel0.93868302
105MP0004510_myositis0.93787035
106MP0001177_atelectasis0.92904626
107MP0000249_abnormal_blood_vessel0.92904534
108MP0009764_decreased_sensitivity_to0.92881311
109MP0005167_abnormal_blood-brain_barrier0.92572668
110MP0004142_abnormal_muscle_tone0.91930940
111MP0009763_increased_sensitivity_to0.90419888
112MP0000703_abnormal_thymus_morphology0.90231563
113MP0000681_abnormal_thyroid_gland0.88255312
114MP0005387_immune_system_phenotype0.87328800
115MP0001790_abnormal_immune_system0.87328800
116MP0003172_abnormal_lysosome_physiology0.86931457
117MP0002160_abnormal_reproductive_system0.86767209
118MP0005084_abnormal_gallbladder_morpholo0.86181563
119MP0001486_abnormal_startle_reflex0.85980274
120MP0001765_abnormal_ion_homeostasis0.85978682
121MP0002822_catalepsy0.84585920
122MP0005075_abnormal_melanosome_morpholog0.84513280
123MP0009333_abnormal_splenocyte_physiolog0.83845113
124MP0001764_abnormal_homeostasis0.83059287
125MP0009765_abnormal_xenobiotic_induced0.81070291
126MP0005164_abnormal_response_to0.79498729
127MP0008469_abnormal_protein_level0.79295067
128MP0001963_abnormal_hearing_physiology0.79257751
129MP0005551_abnormal_eye_electrophysiolog0.78996456
130MP0003075_altered_response_to0.78848032
131MP0005389_reproductive_system_phenotype0.78350976
132MP0001879_abnormal_lymphatic_vessel0.78337161
133MP0000343_altered_response_to0.77791383
134MP0003191_abnormal_cellular_cholesterol0.77787099
135MP0006292_abnormal_olfactory_placode0.76183964
136MP0002184_abnormal_innervation0.75038725
137MP0002693_abnormal_pancreas_physiology0.74876775
138MP0005166_decreased_susceptibility_to0.74793945
139MP0008961_abnormal_basal_metabolism0.74635517
140MP0006082_CNS_inflammation0.73381499
141MP0000230_abnormal_systemic_arterial0.72941103
142MP0005395_other_phenotype0.70377759
143MP0002998_abnormal_bone_remodeling0.70293829
144MP0005025_abnormal_response_to0.70049779
145MP0002933_joint_inflammation0.69250315
146MP0009278_abnormal_bone_marrow0.69234882
147MP0001533_abnormal_skeleton_physiology0.67620849
148MP0008007_abnormal_cellular_replicative0.66334575
149MP0002557_abnormal_social/conspecific_i0.65547759
150MP0002751_abnormal_autonomic_nervous0.64548669
151MP0002452_abnormal_antigen_presenting0.62601707
152MP0002723_abnormal_immune_serum0.61826046
153MP0004742_abnormal_vestibular_system0.61782460

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.56161039
2Hypothermia (HP:0002045)5.37122623
3Prolonged bleeding time (HP:0003010)5.04960251
4Abnormal hair whorl (HP:0010721)4.55094840
5Petechiae (HP:0000967)4.18562249
6Focal motor seizures (HP:0011153)4.00038392
7Elevated erythrocyte sedimentation rate (HP:0003565)3.68727627
8Epistaxis (HP:0000421)3.66311200
9Febrile seizures (HP:0002373)3.62775677
10Gingival bleeding (HP:0000225)3.40158879
11Menorrhagia (HP:0000132)3.38403722
12Abnormal platelet volume (HP:0011876)3.32073696
13Increased mean platelet volume (HP:0011877)3.30810194
14Papillary thyroid carcinoma (HP:0002895)3.30094282
15Atonic seizures (HP:0010819)3.26708233
16Purpura (HP:0000979)3.20234934
17Stomach cancer (HP:0012126)3.12677316
18Medial flaring of the eyebrow (HP:0010747)3.10313012
19Thyroid carcinoma (HP:0002890)3.04229651
20Nephrogenic diabetes insipidus (HP:0009806)2.98277097
21Congenital primary aphakia (HP:0007707)2.95409879
22Gait imbalance (HP:0002141)2.92148293
23Prostate neoplasm (HP:0100787)2.86492567
24Abnormality of T cell number (HP:0011839)2.85491528
25T lymphocytopenia (HP:0005403)2.77326081
26Pancreatic fibrosis (HP:0100732)2.71110793
27Dynein arm defect of respiratory motile cilia (HP:0012255)2.66965585
28Absent/shortened dynein arms (HP:0200106)2.66965585
29Abnormality of the prostate (HP:0008775)2.66831289
30Retrobulbar optic neuritis (HP:0100654)2.66703895
31Optic neuritis (HP:0100653)2.66703895
32Spontaneous hematomas (HP:0007420)2.66055349
33Failure to thrive in infancy (HP:0001531)2.66052657
34Recurrent abscess formation (HP:0002722)2.63472056
35Oligomenorrhea (HP:0000876)2.63462639
36Autoimmune hemolytic anemia (HP:0001890)2.62222413
37Acute necrotizing encephalopathy (HP:0006965)2.60555647
38Leukocytosis (HP:0001974)2.60386943
39Abnormality of eosinophils (HP:0001879)2.59908493
40Submucous cleft hard palate (HP:0000176)2.59442778
41IgG deficiency (HP:0004315)2.56066225
42Poor coordination (HP:0002370)2.54152867
43Irregular epiphyses (HP:0010582)2.53345573
44Fetal akinesia sequence (HP:0001989)2.50546769
45Recurrent bacterial skin infections (HP:0005406)2.48854678
46Severe combined immunodeficiency (HP:0004430)2.48032201
47Abnormal ciliary motility (HP:0012262)2.47877166
48Thyroiditis (HP:0100646)2.46932996
49Episodic fever (HP:0001954)2.46138803
50Progressive macrocephaly (HP:0004481)2.45086684
51Eczematoid dermatitis (HP:0000976)2.44461576
52Tongue fasciculations (HP:0001308)2.43249182
53Alveolar cell carcinoma (HP:0006519)2.41269533
54Joint swelling (HP:0001386)2.36485034
55Increased IgM level (HP:0003496)2.34745448
56Encephalitis (HP:0002383)2.34737005
57Epileptic encephalopathy (HP:0200134)2.33682988
58Azoospermia (HP:0000027)2.33298329
59Type 2 muscle fiber atrophy (HP:0003554)2.32593615
60Abnormal mitochondria in muscle tissue (HP:0008316)2.32037885
61Eosinophilia (HP:0001880)2.31329331
62Keratoconjunctivitis (HP:0001096)2.29637458
63Hyperlipoproteinemia (HP:0010980)2.29425813
64Vasculitis (HP:0002633)2.29020489
65True hermaphroditism (HP:0010459)2.28778877
66Pulmonary infiltrates (HP:0002113)2.28765509
67Abnormality of the vasculature of the conjunctiva (HP:0008054)2.25901943
68Abnormal respiratory motile cilium morphology (HP:0005938)2.22385205
69Abnormal respiratory epithelium morphology (HP:0012253)2.22385205
70Poor suck (HP:0002033)2.21914926
71Conjunctival telangiectasia (HP:0000524)2.21562828
72Neuroendocrine neoplasm (HP:0100634)2.17490129
73Genital tract atresia (HP:0001827)2.16878538
74Abnormality of T cells (HP:0002843)2.16434428
75Renal cortical cysts (HP:0000803)2.16381278
76Abnormal respiratory motile cilium physiology (HP:0012261)2.16251282
77Pustule (HP:0200039)2.15863691
78Dyschromatopsia (HP:0007641)2.15826971
79Pheochromocytoma (HP:0002666)2.14545520
80Abnormality of liposaccharide metabolism (HP:0010968)2.12177367
81Abnormality of glycosphingolipid metabolism (HP:0004343)2.12177367
82Abnormality of glycolipid metabolism (HP:0010969)2.12177367
83Recurrent gram-negative bacterial infections (HP:0005420)2.12175925
84Rhinitis (HP:0012384)2.12104099
85Short nail (HP:0001799)2.09521809
86Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.09324192
87Decreased central vision (HP:0007663)2.07748488
88Vertigo (HP:0002321)2.07180445
89Abnormality of the femoral head (HP:0003368)2.06827875
90Abnormality of incisor morphology (HP:0011063)2.06449682
91Abnormality of the heme biosynthetic pathway (HP:0010472)2.04769098
92Bradycardia (HP:0001662)2.04069019
93Vaginal atresia (HP:0000148)2.03391476
94Hemoptysis (HP:0002105)2.02947605
95Metaphyseal dysplasia (HP:0100255)2.02168217
96Papilledema (HP:0001085)2.00746622
97Recurrent fungal infections (HP:0002841)2.00149985
98Hypoplasia of the fovea (HP:0007750)2.00061687
99Aplasia/Hypoplasia of the fovea (HP:0008060)2.00061687
100Abnormal platelet function (HP:0011869)1.99820503
101Impaired platelet aggregation (HP:0003540)1.99820503
102Abnormality of the labia minora (HP:0012880)1.99475328
103Abnormal delayed hypersensitivity skin test (HP:0002963)1.98723945
104Muscle fibrillation (HP:0010546)1.98239665
105Granulocytopenia (HP:0001913)1.97640625
106Chronic diarrhea (HP:0002028)1.97319949
107Mitochondrial inheritance (HP:0001427)1.96814590
108Progressive inability to walk (HP:0002505)1.96388817
109Neoplasm of the tracheobronchial system (HP:0100552)1.94941918
110Fair hair (HP:0002286)1.94752763
111Cystic hygroma (HP:0000476)1.94163978
112Chest pain (HP:0100749)1.93159891
113Arterial thrombosis (HP:0004420)1.92537943
114Aplasia/Hypoplasia of the lens (HP:0008063)1.92426652
115Hematochezia (HP:0002573)1.91326757
116Disproportionate short-trunk short stature (HP:0003521)1.91303094
117Orchitis (HP:0100796)1.91055628
118Curly hair (HP:0002212)1.90437420
119Autoimmune thrombocytopenia (HP:0001973)1.89138587
120Acute encephalopathy (HP:0006846)1.88767568
121Loss of speech (HP:0002371)1.88452829
122Meningitis (HP:0001287)1.88147256
123Abnormality of dental color (HP:0011073)1.87894893
124Flat capital femoral epiphysis (HP:0003370)1.87563192
125Recurrent sinusitis (HP:0011108)1.87184105
126Progressive cerebellar ataxia (HP:0002073)1.86832690
127Gangrene (HP:0100758)1.86027185
128Pulmonary fibrosis (HP:0002206)1.85963505
129Amyotrophic lateral sclerosis (HP:0007354)1.85612166
1303-Methylglutaconic aciduria (HP:0003535)1.85514823
131Chronic sinusitis (HP:0011109)1.85153204
132Dysautonomia (HP:0002459)1.83542931
133Generalized hypopigmentation of hair (HP:0011358)1.82483630
134Polyphagia (HP:0002591)1.82374430
135Abnormal spermatogenesis (HP:0008669)1.82161106
136Absence seizures (HP:0002121)1.81751785
137Abnormality of the epiphysis of the femoral head (HP:0010574)1.81352548
138Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.80625205
139Male infertility (HP:0003251)1.80247776
140Abnormality of binocular vision (HP:0011514)1.79602821
141Diplopia (HP:0000651)1.79602821
142Pulmonary embolism (HP:0002204)1.79508292
143Hypophosphatemic rickets (HP:0004912)1.78494373
144Mutism (HP:0002300)1.78090074
145Polyneuropathy (HP:0001271)1.76583697
146Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.75919098
147Widely spaced teeth (HP:0000687)1.75589553
148Hypoproteinemia (HP:0003075)1.74845095
149Hyperventilation (HP:0002883)1.74787752
150Increased CSF lactate (HP:0002490)1.74443515
151Infertility (HP:0000789)1.74332202
152Chronic obstructive pulmonary disease (HP:0006510)1.73347425
153Obstructive lung disease (HP:0006536)1.73347425
154Recurrent skin infections (HP:0001581)1.73275072
155Abnormality of T cell physiology (HP:0011840)1.73078568
156Generalized tonic-clonic seizures (HP:0002069)1.72463464
157Hepatocellular necrosis (HP:0001404)1.68653365
158Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.68249196
159Abnormality of femoral epiphyses (HP:0006499)1.68249196
160Birth length less than 3rd percentile (HP:0003561)1.66914918
161Abnormality of the fovea (HP:0000493)1.66430241
162Insulin-resistant diabetes mellitus (HP:0000831)1.66173226
163Focal seizures (HP:0007359)1.65395348
164Pancreatic cysts (HP:0001737)1.64789851
165Dialeptic seizures (HP:0011146)1.64450659
166Vacuolated lymphocytes (HP:0001922)1.64077453
167Vertebral compression fractures (HP:0002953)1.62224443
168Type I transferrin isoform profile (HP:0003642)1.60711585
169Adrenal hypoplasia (HP:0000835)1.59657969
170Broad foot (HP:0001769)1.59291472
171Barrel-shaped chest (HP:0001552)1.59164477
172Muscle fiber atrophy (HP:0100295)1.59144724
173Blue irides (HP:0000635)1.57614110
174Keratoconjunctivitis sicca (HP:0001097)1.57421558
175Myositis (HP:0100614)1.57235061
176Prolonged neonatal jaundice (HP:0006579)1.55583637
177Diminished movement (HP:0002374)1.55544896
178Tetraparesis (HP:0002273)1.55387772
179Abnormality of macrophages (HP:0004311)1.54721260
180Decreased muscle mass (HP:0003199)1.52757291
181Segmental peripheral demyelination/remyelination (HP:0003481)1.50929834
182Glucose intolerance (HP:0000833)1.50013135

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK34.69322790
2CASK3.46188006
3BMPR23.05104383
4AKT32.97752409
5MAP3K122.90207606
6MAP3K142.76223507
7BCR2.68586904
8PRPF4B2.45856541
9SGK22.32854864
10MAP2K72.30311925
11TRIM282.23135587
12ARAF2.15505030
13PLK22.09144243
14STK38L2.01538998
15ERBB31.96389826
16FES1.94074580
17MUSK1.81803162
18IRAK31.78482939
19BMPR1B1.74135092
20RIPK41.74001684
21BTK1.73418118
22ZAK1.68330951
23SGK2231.68192095
24SGK4941.68192095
25NEK91.67733092
26BRAF1.67556420
27GRK61.63567786
28STK241.52330002
29ZAP701.51651595
30MAP4K21.51091049
31ITK1.49357082
32FRK1.45281061
33MAP4K11.43469124
34HCK1.40429786
35NTRK31.38764530
36ADRBK21.37493260
37MST41.37108537
38EIF2AK11.33781175
39PLK41.29802580
40CSF1R1.29549907
41ERBB41.28573929
42PIK3CG1.28037258
43SGK31.27292988
44IRAK41.26658097
45NEK61.23845285
46PINK11.20845668
47MINK11.19353151
48JAK11.11405097
49PIM21.08790838
50KSR11.08048689
51MAPK131.07006444
52PTK2B1.06801078
53MAP3K61.03682484
54MAP3K41.02005937
55TXK0.97785170
56LYN0.97371547
57CDK190.97360470
58TYK20.95944985
59GRK70.92635566
60LCK0.92450251
61KIT0.90248274
62CDK80.90201220
63PRKCE0.89921968
64CSK0.89646233
65TRPM70.88799670
66YES10.88326799
67EPHA30.87651417
68PBK0.87628636
69MAPK150.87293969
70CHUK0.85453051
71PAK30.85141399
72EPHB10.84519416
73GRK50.83861348
74ACVR1B0.82093367
75OXSR10.81488010
76IKBKE0.80096116
77PLK30.77368975
78MOS0.75263092
79FER0.73787760
80PRKCQ0.72303128
81GRK10.71367912
82MAP3K50.67866093
83BLK0.67278021
84MYLK0.66335582
85MAPK70.65581704
86VRK10.65498287
87IRAK10.65374854
88PRKD30.64935464
89IKBKB0.63471855
90CDK30.62402571
91MKNK20.60997430
92JAK20.60256837
93NME10.59844465
94DYRK20.57235925
95WNK30.56040786
96ADRBK10.53468348
97FLT30.53293842
98IRAK20.52455143
99TGFBR20.52052893
100ABL10.51420804
101PDK10.50664558
102IGF1R0.50276912
103EIF2AK30.50247846
104FGFR30.50094019
105JAK30.49567707
106MAP2K40.49467139
107FGR0.49373959
108INSRR0.48980855
109CAMK2A0.48626804
110HIPK20.48047395
111TIE10.47935882
112BRSK20.46991933
113MARK30.46751719
114EGFR0.46423987
115CAMKK20.46323760
116TNIK0.45608699
117MAP2K10.45521282
118LATS20.44117244
119STK30.43800406
120PRKG10.43391632
121PDK20.43190331
122TEC0.42946365
123LIMK10.42688595
124DYRK1A0.42321674
125TNK20.41916091
126RPS6KB10.41784590
127MAP3K30.41720482
128TAOK30.41338130
129MAPKAPK30.40249295
130ABL20.40106130
131MATK0.39735494
132RPS6KA20.39672520
133PIK3CA0.39590600
134PIM10.39244498
135MAP3K10.39164308
136PRKCD0.38319293
137PRKD10.38058887
138MAP3K90.36521470
139DAPK10.36259036
140PRKCG0.35019994
141EIF2AK20.33604043
142MAP3K20.33346888
143SGK10.32985704
144MAP3K130.32460758
145RAF10.31062811
146TBK10.30369433
147NUAK10.30228862
148NLK0.27908625
149TSSK60.26171860
150DAPK20.25751843
151SYK0.24894426

Predicted pathways (KEGG)

RankGene SetZ-score
1Collecting duct acid secretion_Homo sapiens_hsa049664.05531955
2Synaptic vesicle cycle_Homo sapiens_hsa047213.16424295
3Rheumatoid arthritis_Homo sapiens_hsa053232.96630162
4SNARE interactions in vesicular transport_Homo sapiens_hsa041302.90937424
5Protein export_Homo sapiens_hsa030602.46538557
6Vibrio cholerae infection_Homo sapiens_hsa051102.37254817
7Type I diabetes mellitus_Homo sapiens_hsa049402.13596216
8Phagosome_Homo sapiens_hsa041452.13589091
9Primary immunodeficiency_Homo sapiens_hsa053402.02156512
10Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.92840574
11Graft-versus-host disease_Homo sapiens_hsa053321.91127150
12Basal transcription factors_Homo sapiens_hsa030221.89429699
13Platelet activation_Homo sapiens_hsa046111.89266889
14Oxidative phosphorylation_Homo sapiens_hsa001901.88718764
15T cell receptor signaling pathway_Homo sapiens_hsa046601.77270750
16Olfactory transduction_Homo sapiens_hsa047401.74810493
17Allograft rejection_Homo sapiens_hsa053301.73808168
18Regulation of autophagy_Homo sapiens_hsa041401.70538319
19Osteoclast differentiation_Homo sapiens_hsa043801.70349391
20Nicotine addiction_Homo sapiens_hsa050331.67055490
21Proteasome_Homo sapiens_hsa030501.59371218
22Serotonergic synapse_Homo sapiens_hsa047261.47588903
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46514418
24Vitamin B6 metabolism_Homo sapiens_hsa007501.36205046
25Circadian rhythm_Homo sapiens_hsa047101.35788449
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33330491
27Autoimmune thyroid disease_Homo sapiens_hsa053201.31347012
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.29298619
29B cell receptor signaling pathway_Homo sapiens_hsa046621.27842476
30Morphine addiction_Homo sapiens_hsa050321.26229118
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25366860
32Sphingolipid metabolism_Homo sapiens_hsa006001.20777623
33Legionellosis_Homo sapiens_hsa051341.20103939
34Taste transduction_Homo sapiens_hsa047421.19533190
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16471754
36GABAergic synapse_Homo sapiens_hsa047271.15806569
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09661054
38Phototransduction_Homo sapiens_hsa047441.08763080
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08606545
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07667788
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.07241710
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03569305
43Lysosome_Homo sapiens_hsa041421.00563366
44Sulfur metabolism_Homo sapiens_hsa009201.00199747
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99489988
46Salmonella infection_Homo sapiens_hsa051320.99139408
47Pertussis_Homo sapiens_hsa051330.98871959
48RNA polymerase_Homo sapiens_hsa030200.98649577
49Leishmaniasis_Homo sapiens_hsa051400.98409376
50Antigen processing and presentation_Homo sapiens_hsa046120.97779166
51Amphetamine addiction_Homo sapiens_hsa050310.97620973
52Tuberculosis_Homo sapiens_hsa051520.97492898
53Huntingtons disease_Homo sapiens_hsa050160.97255671
54Dopaminergic synapse_Homo sapiens_hsa047280.96567589
55Parkinsons disease_Homo sapiens_hsa050120.95194230
56Circadian entrainment_Homo sapiens_hsa047130.95023321
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.94435537
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.92570351
59Insulin secretion_Homo sapiens_hsa049110.92563265
60Renin secretion_Homo sapiens_hsa049240.90149054
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90043299
62Prolactin signaling pathway_Homo sapiens_hsa049170.88621898
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88309202
64Dorso-ventral axis formation_Homo sapiens_hsa043200.84627763
65Influenza A_Homo sapiens_hsa051640.83007578
66African trypanosomiasis_Homo sapiens_hsa051430.82417904
67Viral myocarditis_Homo sapiens_hsa054160.82155530
68Toxoplasmosis_Homo sapiens_hsa051450.80609645
69Caffeine metabolism_Homo sapiens_hsa002320.80552421
70Long-term potentiation_Homo sapiens_hsa047200.80087454
71Asthma_Homo sapiens_hsa053100.78588924
72Endocytosis_Homo sapiens_hsa041440.76914134
73Herpes simplex infection_Homo sapiens_hsa051680.76572758
74Alzheimers disease_Homo sapiens_hsa050100.74947432
75Arachidonic acid metabolism_Homo sapiens_hsa005900.73660145
76Cocaine addiction_Homo sapiens_hsa050300.73548180
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.73400090
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72246842
79Nitrogen metabolism_Homo sapiens_hsa009100.71871966
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70793178
81Chemokine signaling pathway_Homo sapiens_hsa040620.70116645
82Ether lipid metabolism_Homo sapiens_hsa005650.69917768
83Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68088232
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68003799
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67875037
86Measles_Homo sapiens_hsa051620.65362179
87Linoleic acid metabolism_Homo sapiens_hsa005910.65327721
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65302456
89Glutamatergic synapse_Homo sapiens_hsa047240.64819964
90Malaria_Homo sapiens_hsa051440.62665413
91Salivary secretion_Homo sapiens_hsa049700.62616635
92Cholinergic synapse_Homo sapiens_hsa047250.62582581
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60979166
94Pancreatic secretion_Homo sapiens_hsa049720.59874415
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.59439575
96Other glycan degradation_Homo sapiens_hsa005110.59391923
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57655980
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57358379
99Shigellosis_Homo sapiens_hsa051310.55882919
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55667961
101Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54765451
102Staphylococcus aureus infection_Homo sapiens_hsa051500.53098331
103Long-term depression_Homo sapiens_hsa047300.51998928
104TNF signaling pathway_Homo sapiens_hsa046680.51664116
105FoxO signaling pathway_Homo sapiens_hsa040680.51425742
106Oxytocin signaling pathway_Homo sapiens_hsa049210.50617526
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.49825392
108Thyroid cancer_Homo sapiens_hsa052160.47625862
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47621233
110RNA degradation_Homo sapiens_hsa030180.46789445
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46629056
112cAMP signaling pathway_Homo sapiens_hsa040240.45804796
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45700382
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44850232
115Melanoma_Homo sapiens_hsa052180.44763016
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42960735
117Epstein-Barr virus infection_Homo sapiens_hsa051690.42095460
118Steroid biosynthesis_Homo sapiens_hsa001000.41634889
119Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41326541
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40190060
121NF-kappa B signaling pathway_Homo sapiens_hsa040640.37074915
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.36607543
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35937904
124Hepatitis B_Homo sapiens_hsa051610.35733460
125Purine metabolism_Homo sapiens_hsa002300.35295697
126Calcium signaling pathway_Homo sapiens_hsa040200.33100177
127Ovarian steroidogenesis_Homo sapiens_hsa049130.31645844
128Hematopoietic cell lineage_Homo sapiens_hsa046400.31320892
129Maturity onset diabetes of the young_Homo sapiens_hsa049500.30293237
130MAPK signaling pathway_Homo sapiens_hsa040100.30221757
131Ras signaling pathway_Homo sapiens_hsa040140.29959208

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