

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosomal small subunit assembly (GO:0000028) | 5.65279364 |
| 2 | DNA deamination (GO:0045006) | 5.58422233 |
| 3 | viral transcription (GO:0019083) | 5.53986511 |
| 4 | translational termination (GO:0006415) | 5.48966564 |
| 5 | maturation of SSU-rRNA (GO:0030490) | 5.23044448 |
| 6 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 5.20953822 |
| 7 | protein targeting to ER (GO:0045047) | 5.08476187 |
| 8 | cotranslational protein targeting to membrane (GO:0006613) | 5.06969486 |
| 9 | ribosomal small subunit biogenesis (GO:0042274) | 4.98026341 |
| 10 | regulation of vitamin D biosynthetic process (GO:0060556) | 4.96060910 |
| 11 | formation of translation preinitiation complex (GO:0001731) | 4.86616865 |
| 12 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.84939088 |
| 13 | protein localization to endoplasmic reticulum (GO:0070972) | 4.80697607 |
| 14 | translational elongation (GO:0006414) | 4.74630837 |
| 15 | translational initiation (GO:0006413) | 4.67083759 |
| 16 | negative regulation of retinoic acid receptor signaling pathway (GO:0048387) | 4.65129681 |
| 17 | ribosomal large subunit biogenesis (GO:0042273) | 4.57466426 |
| 18 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.50136265 |
| 19 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.27544957 |
| 20 | viral life cycle (GO:0019058) | 4.25454968 |
| 21 | cellular protein complex disassembly (GO:0043624) | 4.18649048 |
| 22 | ribosome biogenesis (GO:0042254) | 4.00852418 |
| 23 | regulation of retinoic acid receptor signaling pathway (GO:0048385) | 3.84257944 |
| 24 | rRNA processing (GO:0006364) | 3.79409631 |
| 25 | regulation of vitamin metabolic process (GO:0030656) | 3.74194555 |
| 26 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.72490152 |
| 27 | translation (GO:0006412) | 3.71630765 |
| 28 | protein complex disassembly (GO:0043241) | 3.70206454 |
| 29 | rRNA metabolic process (GO:0016072) | 3.67857235 |
| 30 | ribosome assembly (GO:0042255) | 3.60315243 |
| 31 | pseudouridine synthesis (GO:0001522) | 3.57197380 |
| 32 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.56860890 |
| 33 | DNA replication initiation (GO:0006270) | 3.53736946 |
| 34 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.52829930 |
| 35 | macromolecular complex disassembly (GO:0032984) | 3.50718380 |
| 36 | cellular protein complex localization (GO:0034629) | 3.41570344 |
| 37 | mRNA catabolic process (GO:0006402) | 3.41178386 |
| 38 | DNA strand elongation (GO:0022616) | 3.37253578 |
| 39 | nucleobase biosynthetic process (GO:0046112) | 3.37001496 |
| 40 | NIK/NF-kappaB signaling (GO:0038061) | 3.36433232 |
| 41 | protein targeting to membrane (GO:0006612) | 3.34972739 |
| 42 | RNA catabolic process (GO:0006401) | 3.32825596 |
| 43 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.27788333 |
| 44 | mitotic chromosome condensation (GO:0007076) | 3.21564847 |
| 45 | termination of RNA polymerase III transcription (GO:0006386) | 3.20266942 |
| 46 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.20266942 |
| 47 | folic acid metabolic process (GO:0046655) | 3.18900693 |
| 48 | regulation of translational fidelity (GO:0006450) | 3.17561425 |
| 49 | purine nucleobase biosynthetic process (GO:0009113) | 3.17360390 |
| 50 | nuclear pore complex assembly (GO:0051292) | 3.11763333 |
| 51 | cellular component biogenesis (GO:0044085) | 3.11296499 |
| 52 | rRNA modification (GO:0000154) | 3.09735470 |
| 53 | viral mRNA export from host cell nucleus (GO:0046784) | 3.09286623 |
| 54 | regulation of translational termination (GO:0006449) | 3.09166772 |
| 55 | positive regulation of protein homooligomerization (GO:0032464) | 3.04542581 |
| 56 | DNA unwinding involved in DNA replication (GO:0006268) | 3.02840440 |
| 57 | spliceosomal snRNP assembly (GO:0000387) | 3.00077808 |
| 58 | protein complex localization (GO:0031503) | 2.97216488 |
| 59 | DNA replication checkpoint (GO:0000076) | 2.96837470 |
| 60 | mitotic nuclear envelope disassembly (GO:0007077) | 2.91586859 |
| 61 | pteridine-containing compound biosynthetic process (GO:0042559) | 2.87705618 |
| 62 | negative regulation of RNA splicing (GO:0033119) | 2.86679460 |
| 63 | ncRNA processing (GO:0034470) | 2.85501875 |
| 64 | proteasome assembly (GO:0043248) | 2.85446924 |
| 65 | rRNA transcription (GO:0009303) | 2.84075321 |
| 66 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.81170760 |
| 67 | DNA replication-dependent nucleosome assembly (GO:0006335) | 2.80275152 |
| 68 | DNA replication-dependent nucleosome organization (GO:0034723) | 2.80275152 |
| 69 | regulation of chronic inflammatory response (GO:0002676) | 2.78782157 |
| 70 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 2.76799411 |
| 71 | protein localization to kinetochore (GO:0034501) | 2.76276706 |
| 72 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 2.76135058 |
| 73 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 2.75901429 |
| 74 | mitochondrial fusion (GO:0008053) | 2.75189100 |
| 75 | nuclear pore organization (GO:0006999) | 2.75132229 |
| 76 | telomere maintenance via recombination (GO:0000722) | 2.74897368 |
| 77 | ncRNA metabolic process (GO:0034660) | 2.73302436 |
| 78 | IMP biosynthetic process (GO:0006188) | 2.72656455 |
| 79 | membrane disassembly (GO:0030397) | 2.72422363 |
| 80 | nuclear envelope disassembly (GO:0051081) | 2.72422363 |
| 81 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.72334564 |
| 82 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 2.72046074 |
| 83 | tRNA modification (GO:0006400) | 2.69066210 |
| 84 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.68147521 |
| 85 | proline biosynthetic process (GO:0006561) | 2.68135132 |
| 86 | tRNA methylation (GO:0030488) | 2.67882893 |
| 87 | protein targeting to mitochondrion (GO:0006626) | 2.67645044 |
| 88 | mitotic metaphase plate congression (GO:0007080) | 2.66126983 |
| 89 | activation of MAPKKK activity (GO:0000185) | 2.64411912 |
| 90 | T cell apoptotic process (GO:0070231) | 2.63116877 |
| 91 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.61093818 |
| 92 | regulation of translation in response to stress (GO:0043555) | 2.61067272 |
| 93 | telomere maintenance via telomere lengthening (GO:0010833) | 2.59319032 |
| 94 | positive regulation of protein oligomerization (GO:0032461) | 2.58489941 |
| 95 | pore complex assembly (GO:0046931) | 2.58167956 |
| 96 | ncRNA 3-end processing (GO:0043628) | 2.57737615 |
| 97 | purine nucleotide salvage (GO:0032261) | 2.55002385 |
| 98 | dosage compensation (GO:0007549) | 2.54268025 |
| 99 | transcription from RNA polymerase I promoter (GO:0006360) | 2.54025470 |
| 100 | termination of RNA polymerase I transcription (GO:0006363) | 2.53540018 |
| 101 | interferon-gamma secretion (GO:0072643) | 2.53129173 |
| 102 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO | 2.52475287 |
| 103 | mitotic recombination (GO:0006312) | 2.52354400 |
| 104 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.52245783 |
| 105 | establishment of protein localization to mitochondrion (GO:0072655) | 2.50797729 |
| 106 | regulation of mammary gland epithelial cell proliferation (GO:0033599) | 2.50625092 |
| 107 | regulation of mitochondrial translation (GO:0070129) | 2.50495912 |
| 108 | regulation of podosome assembly (GO:0071801) | 2.50320140 |
| 109 | rRNA methylation (GO:0031167) | 2.49334757 |
| 110 | mitochondrial RNA metabolic process (GO:0000959) | 2.49057678 |
| 111 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.48964699 |
| 112 | protein localization to chromosome, centromeric region (GO:0071459) | 2.48739967 |
| 113 | regulation of helicase activity (GO:0051095) | 2.48352658 |
| 114 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.48330821 |
| 115 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.48093766 |
| 116 | IMP metabolic process (GO:0046040) | 2.47421755 |
| 117 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 2.46657416 |
| 118 | spliceosomal complex assembly (GO:0000245) | 2.46368632 |
| 119 | protein maturation by protein folding (GO:0022417) | 2.46223733 |
| 120 | maturation of 5.8S rRNA (GO:0000460) | 2.46064830 |
| 121 | cell cycle G1/S phase transition (GO:0044843) | 2.45253229 |
| 122 | G1/S transition of mitotic cell cycle (GO:0000082) | 2.45253229 |
| 123 | negative regulation of ligase activity (GO:0051352) | 2.45241353 |
| 124 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.45241353 |
| 125 | nucleobase-containing small molecule interconversion (GO:0015949) | 2.44997410 |
| 126 | tolerance induction (GO:0002507) | 2.44587110 |
| 127 | negative regulation of mRNA processing (GO:0050686) | 2.44578465 |
| 128 | DNA-templated transcription, termination (GO:0006353) | 2.44472352 |
| 129 | RNA splicing, via transesterification reactions (GO:0000375) | 2.44441238 |
| 130 | cellular response to arsenic-containing substance (GO:0071243) | 2.43962350 |
| 131 | ribonucleoprotein complex assembly (GO:0022618) | 2.42909684 |
| 132 | mitochondrial DNA metabolic process (GO:0032042) | 2.42643664 |
| 133 | transcription from mitochondrial promoter (GO:0006390) | 2.42376674 |
| 134 | response to peptidoglycan (GO:0032494) | 2.40971790 |
| 135 | regulation of RIG-I signaling pathway (GO:0039535) | 2.39527059 |
| 136 | pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130) | 2.39092559 |
| 137 | myeloid dendritic cell differentiation (GO:0043011) | 2.38918435 |
| 138 | positive regulation of chromosome segregation (GO:0051984) | 2.38543061 |
| 139 | nucleotide salvage (GO:0043173) | 2.38438501 |
| 140 | spliceosomal tri-snRNP complex assembly (GO:0000244) | 2.34665609 |
| 141 | pyrimidine nucleoside monophosphate metabolic process (GO:0009129) | 2.32651781 |
| 142 | regulation of translational elongation (GO:0006448) | 2.32558954 |
| 143 | negative regulation of interleukin-12 production (GO:0032695) | 2.32124502 |
| 144 | mitotic sister chromatid segregation (GO:0000070) | 2.32056923 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.71100264 |
| 2 | * MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.43785747 |
| 3 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.78679321 |
| 4 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.98590198 |
| 5 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.93207603 |
| 6 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.87284314 |
| 7 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.82307266 |
| 8 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.77857845 |
| 9 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.72880654 |
| 10 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.68449892 |
| 11 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.64500160 |
| 12 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.47619277 |
| 13 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.39692434 |
| 14 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.30961522 |
| 15 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.24659696 |
| 16 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.20621555 |
| 17 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.19826894 |
| 18 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.14329635 |
| 19 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.13977797 |
| 20 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.12474871 |
| 21 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.11790796 |
| 22 | MYC_22102868_ChIP-Seq_BL_Human | 2.10617480 |
| 23 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.08856366 |
| 24 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 2.05907728 |
| 25 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.03691295 |
| 26 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.99174467 |
| 27 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.97109531 |
| 28 | * GABP_19822575_ChIP-Seq_HepG2_Human | 1.93742536 |
| 29 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.93715353 |
| 30 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.85451368 |
| 31 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.83274337 |
| 32 | * MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.83106777 |
| 33 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.76122639 |
| 34 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.75731439 |
| 35 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.72804852 |
| 36 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.70049497 |
| 37 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.67931112 |
| 38 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.61391272 |
| 39 | * SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.60163379 |
| 40 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.59015998 |
| 41 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.56747489 |
| 42 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.55632054 |
| 43 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.55203033 |
| 44 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.52898811 |
| 45 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.50914809 |
| 46 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.50731086 |
| 47 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.50428920 |
| 48 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.50377904 |
| 49 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.45418084 |
| 50 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.45344406 |
| 51 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.45332529 |
| 52 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.45004831 |
| 53 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.44803988 |
| 54 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.43403222 |
| 55 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.39677125 |
| 56 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.39321424 |
| 57 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.39274753 |
| 58 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.38979236 |
| 59 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.36400184 |
| 60 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.35682953 |
| 61 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.32326189 |
| 62 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.27860869 |
| 63 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.27002703 |
| 64 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.26762077 |
| 65 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.26714216 |
| 66 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.25415113 |
| 67 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.24571924 |
| 68 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.22699550 |
| 69 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.20638428 |
| 70 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.20267761 |
| 71 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.17470766 |
| 72 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.16860346 |
| 73 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.16171742 |
| 74 | * CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.13958415 |
| 75 | * ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.12553716 |
| 76 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.11281474 |
| 77 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.10944339 |
| 78 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.10567677 |
| 79 | * ATF3_27146783_Chip-Seq_COLON_Human | 1.10475508 |
| 80 | * KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.10285863 |
| 81 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.09710747 |
| 82 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.09378280 |
| 83 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.09334920 |
| 84 | MAF_26560356_Chip-Seq_TH2_Human | 1.09324949 |
| 85 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.08385860 |
| 86 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.08361665 |
| 87 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.08063035 |
| 88 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.07139354 |
| 89 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.06499996 |
| 90 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.06047028 |
| 91 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.03675609 |
| 92 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.03675609 |
| 93 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.03675609 |
| 94 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.03638290 |
| 95 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.02547716 |
| 96 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.01782650 |
| 97 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.01244888 |
| 98 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.00496573 |
| 99 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.00274882 |
| 100 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 1.00007471 |
| 101 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.98406115 |
| 102 | MYB_26560356_Chip-Seq_TH1_Human | 0.98159692 |
| 103 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.97958657 |
| 104 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.97406375 |
| 105 | MYB_26560356_Chip-Seq_TH2_Human | 0.97334853 |
| 106 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.96381177 |
| 107 | MAF_26560356_Chip-Seq_TH1_Human | 0.96330564 |
| 108 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.94918672 |
| 109 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.94876108 |
| 110 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.94329048 |
| 111 | UTX_26944678_Chip-Seq_JUKART_Human | 0.94277952 |
| 112 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.93682841 |
| 113 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.91244071 |
| 114 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.90947753 |
| 115 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.90937137 |
| 116 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.89153918 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 4.96860510 |
| 2 | MP0008057_abnormal_DNA_replication | 3.88032617 |
| 3 | MP0004957_abnormal_blastocyst_morpholog | 3.82496947 |
| 4 | MP0003303_peritoneal_inflammation | 3.04746188 |
| 5 | MP0010094_abnormal_chromosome_stability | 2.95291739 |
| 6 | MP0003111_abnormal_nucleus_morphology | 2.92343841 |
| 7 | MP0003077_abnormal_cell_cycle | 2.90026233 |
| 8 | MP0008007_abnormal_cellular_replicative | 2.78578423 |
| 9 | MP0008058_abnormal_DNA_repair | 2.56296679 |
| 10 | MP0002396_abnormal_hematopoietic_system | 2.55271565 |
| 11 | MP0005451_abnormal_body_composition | 2.38932132 |
| 12 | MP0000490_abnormal_crypts_of | 2.22479702 |
| 13 | MP0009333_abnormal_splenocyte_physiolog | 2.22285084 |
| 14 | MP0010352_gastrointestinal_tract_polyps | 2.20494173 |
| 15 | MP0009840_abnormal_foam_cell | 2.02408107 |
| 16 | MP0003786_premature_aging | 2.00725277 |
| 17 | MP0003763_abnormal_thymus_physiology | 1.99493657 |
| 18 | MP0003436_decreased_susceptibility_to | 1.82829870 |
| 19 | MP0000350_abnormal_cell_proliferation | 1.78515845 |
| 20 | MP0000685_abnormal_immune_system | 1.74720545 |
| 21 | MP0003656_abnormal_erythrocyte_physiolo | 1.71943224 |
| 22 | MP0009379_abnormal_foot_pigmentation | 1.71061734 |
| 23 | MP0008932_abnormal_embryonic_tissue | 1.68994417 |
| 24 | MP0008260_abnormal_autophagy | 1.66665875 |
| 25 | MP0002163_abnormal_gland_morphology | 1.66127537 |
| 26 | MP0002398_abnormal_bone_marrow | 1.65909384 |
| 27 | MP0004185_abnormal_adipocyte_glucose | 1.59304566 |
| 28 | MP0001835_abnormal_antigen_presentation | 1.58729896 |
| 29 | MP0003806_abnormal_nucleotide_metabolis | 1.58507975 |
| 30 | MP0004808_abnormal_hematopoietic_stem | 1.57696333 |
| 31 | MP0005220_abnormal_exocrine_pancreas | 1.49596722 |
| 32 | MP0001730_embryonic_growth_arrest | 1.49148907 |
| 33 | MP0002877_abnormal_melanocyte_morpholog | 1.48879261 |
| 34 | MP0001545_abnormal_hematopoietic_system | 1.47695155 |
| 35 | MP0005397_hematopoietic_system_phenotyp | 1.47695155 |
| 36 | MP0002019_abnormal_tumor_incidence | 1.47081393 |
| 37 | MP0005075_abnormal_melanosome_morpholog | 1.46190621 |
| 38 | MP0005058_abnormal_lysosome_morphology | 1.45484476 |
| 39 | MP0000689_abnormal_spleen_morphology | 1.45091206 |
| 40 | MP0005000_abnormal_immune_tolerance | 1.41918511 |
| 41 | MP0005671_abnormal_response_to | 1.39782569 |
| 42 | MP0002009_preneoplasia | 1.39683357 |
| 43 | MP0002405_respiratory_system_inflammati | 1.39405748 |
| 44 | MP0000703_abnormal_thymus_morphology | 1.38882010 |
| 45 | MP0009785_altered_susceptibility_to | 1.38468153 |
| 46 | MP0002722_abnormal_immune_system | 1.38360009 |
| 47 | MP0003300_gastrointestinal_ulcer | 1.37352682 |
| 48 | MP0004233_abnormal_muscle_weight | 1.37300735 |
| 49 | MP0004147_increased_porphyrin_level | 1.34767623 |
| 50 | MP0002796_impaired_skin_barrier | 1.34440243 |
| 51 | MP0000313_abnormal_cell_death | 1.33948136 |
| 52 | MP0000465_gastrointestinal_hemorrhage | 1.33380843 |
| 53 | MP0002132_abnormal_respiratory_system | 1.33318224 |
| 54 | MP0002723_abnormal_immune_serum | 1.32983816 |
| 55 | MP0001853_heart_inflammation | 1.32824319 |
| 56 | MP0003123_paternal_imprinting | 1.32365244 |
| 57 | MP0010234_abnormal_vibrissa_follicle | 1.30463178 |
| 58 | MP0001800_abnormal_humoral_immune | 1.29128768 |
| 59 | MP0001697_abnormal_embryo_size | 1.28822398 |
| 60 | MP0002420_abnormal_adaptive_immunity | 1.28525130 |
| 61 | MP0002429_abnormal_blood_cell | 1.27870518 |
| 62 | MP0000716_abnormal_immune_system | 1.27831550 |
| 63 | MP0005501_abnormal_skin_physiology | 1.25767413 |
| 64 | MP0001819_abnormal_immune_cell | 1.25703227 |
| 65 | MP0001348_abnormal_lacrimal_gland | 1.25594150 |
| 66 | MP0005174_abnormal_tail_pigmentation | 1.24449359 |
| 67 | MP0002080_prenatal_lethality | 1.23911603 |
| 68 | MP0006035_abnormal_mitochondrial_morpho | 1.22897959 |
| 69 | MP0005310_abnormal_salivary_gland | 1.22233461 |
| 70 | MP0005025_abnormal_response_to | 1.21897268 |
| 71 | MP0000858_altered_metastatic_potential | 1.21657076 |
| 72 | MP0002452_abnormal_antigen_presenting | 1.19794302 |
| 73 | MP0002166_altered_tumor_susceptibility | 1.17318052 |
| 74 | MP0001919_abnormal_reproductive_system | 1.17230957 |
| 75 | MP0010307_abnormal_tumor_latency | 1.16659897 |
| 76 | MP0003866_abnormal_defecation | 1.15228583 |
| 77 | MP0002693_abnormal_pancreas_physiology | 1.12143655 |
| 78 | MP0001672_abnormal_embryogenesis/_devel | 1.11300009 |
| 79 | MP0005380_embryogenesis_phenotype | 1.11300009 |
| 80 | MP0001727_abnormal_embryo_implantation | 1.11134309 |
| 81 | MP0003315_abnormal_perineum_morphology | 1.10882791 |
| 82 | MP0010155_abnormal_intestine_physiology | 1.09869681 |
| 83 | MP0000678_abnormal_parathyroid_gland | 1.08604594 |
| 84 | MP0002138_abnormal_hepatobiliary_system | 1.07429795 |
| 85 | MP0001661_extended_life_span | 1.06991851 |
| 86 | MP0003646_muscle_fatigue | 1.06432174 |
| 87 | MP0004947_skin_inflammation | 1.03948648 |
| 88 | MP0000358_abnormal_cell_content/ | 1.03096046 |
| 89 | MP0002086_abnormal_extraembryonic_tissu | 1.00804932 |
| 90 | MP0001145_abnormal_male_reproductive | 0.99585965 |
| 91 | MP0003718_maternal_effect | 0.98847081 |
| 92 | MP0003984_embryonic_growth_retardation | 0.98761439 |
| 93 | MP0002210_abnormal_sex_determination | 0.98090000 |
| 94 | MP0002088_abnormal_embryonic_growth/wei | 0.97843510 |
| 95 | MP0000015_abnormal_ear_pigmentation | 0.97213353 |
| 96 | MP0001790_abnormal_immune_system | 0.96068974 |
| 97 | MP0005387_immune_system_phenotype | 0.96068974 |
| 98 | MP0002006_tumorigenesis | 0.95942994 |
| 99 | MP0004197_abnormal_fetal_growth/weight/ | 0.94734155 |
| 100 | MP0002085_abnormal_embryonic_tissue | 0.93825712 |
| 101 | MP0002084_abnormal_developmental_patter | 0.91529535 |
| 102 | MP0001845_abnormal_inflammatory_respons | 0.89585865 |
| 103 | MP0003186_abnormal_redox_activity | 0.88835500 |
| 104 | MP0005076_abnormal_cell_differentiation | 0.88634102 |
| 105 | MP0001881_abnormal_mammary_gland | 0.88209690 |
| 106 | MP0001929_abnormal_gametogenesis | 0.87386314 |
| 107 | MP0002148_abnormal_hypersensitivity_rea | 0.87315957 |
| 108 | MP0000477_abnormal_intestine_morphology | 0.86720875 |
| 109 | MP0003724_increased_susceptibility_to | 0.86679776 |
| 110 | MP0005464_abnormal_platelet_physiology | 0.86559655 |
| 111 | MP0006036_abnormal_mitochondrial_physio | 0.85849527 |
| 112 | MP0005379_endocrine/exocrine_gland_phen | 0.85832725 |
| 113 | MP0000371_diluted_coat_color | 0.85161183 |
| 114 | MP0000627_abnormal_mammary_gland | 0.84073697 |
| 115 | MP0004510_myositis | 0.83462322 |
| 116 | MP0001216_abnormal_epidermal_layer | 0.82750367 |
| 117 | MP0003448_altered_tumor_morphology | 0.80359182 |
| 118 | MP0002095_abnormal_skin_pigmentation | 0.80053223 |
| 119 | MP0009764_decreased_sensitivity_to | 0.80034480 |
| 120 | MP0003453_abnormal_keratinocyte_physiol | 0.79600784 |
| 121 | MP0002933_joint_inflammation | 0.79352679 |
| 122 | MP0000343_altered_response_to | 0.79290708 |
| 123 | MP0003221_abnormal_cardiomyocyte_apopto | 0.78794892 |
| 124 | MP0001944_abnormal_pancreas_morphology | 0.78258703 |
| 125 | MP0003567_abnormal_fetal_cardiomyocyte | 0.77429820 |
| 126 | MP0000653_abnormal_sex_gland | 0.76954250 |
| 127 | MP0001873_stomach_inflammation | 0.76457610 |
| 128 | MP0006054_spinal_hemorrhage | 0.75786961 |
| 129 | MP0008995_early_reproductive_senescence | 0.74380278 |
| 130 | MP0005621_abnormal_cell_physiology | 0.73289145 |
| 131 | MP0002419_abnormal_innate_immunity | 0.72784789 |
| 132 | MP0009278_abnormal_bone_marrow | 0.72629860 |
| 133 | MP0003868_abnormal_feces_composition | 0.72007649 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 5.91354847 |
| 2 | Abnormal number of erythroid precursors (HP:0012131) | 5.42704847 |
| 3 | Reticulocytopenia (HP:0001896) | 5.01145913 |
| 4 | Aplastic anemia (HP:0001915) | 4.28882590 |
| 5 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 4.23203086 |
| 6 | Birth length less than 3rd percentile (HP:0003561) | 4.02324434 |
| 7 | Pallor (HP:0000980) | 3.95289648 |
| 8 | Macrocytic anemia (HP:0001972) | 3.90135467 |
| 9 | Thrombocytosis (HP:0001894) | 3.71405902 |
| 10 | Progressive external ophthalmoplegia (HP:0000590) | 3.60319308 |
| 11 | 11 pairs of ribs (HP:0000878) | 3.55511973 |
| 12 | Oral leukoplakia (HP:0002745) | 3.44882654 |
| 13 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.41484504 |
| 14 | Rough bone trabeculation (HP:0100670) | 3.40204551 |
| 15 | Ragged-red muscle fibers (HP:0003200) | 3.38499284 |
| 16 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.36948113 |
| 17 | B lymphocytopenia (HP:0010976) | 3.23989155 |
| 18 | Carpal bone hypoplasia (HP:0001498) | 3.19752306 |
| 19 | Glossoptosis (HP:0000162) | 3.16124570 |
| 20 | Chromsome breakage (HP:0040012) | 3.16057515 |
| 21 | Abnormality of T cell physiology (HP:0011840) | 3.08593160 |
| 22 | Increased hepatocellular lipid droplets (HP:0006565) | 3.04617533 |
| 23 | Progressive muscle weakness (HP:0003323) | 2.91448346 |
| 24 | Testicular atrophy (HP:0000029) | 2.88034577 |
| 25 | Increased intramyocellular lipid droplets (HP:0012240) | 2.87954482 |
| 26 | Lipid accumulation in hepatocytes (HP:0006561) | 2.85180486 |
| 27 | Absent thumb (HP:0009777) | 2.84688322 |
| 28 | IgA deficiency (HP:0002720) | 2.83709204 |
| 29 | Trismus (HP:0000211) | 2.76405775 |
| 30 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.73344949 |
| 31 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.73344949 |
| 32 | Abnormal protein glycosylation (HP:0012346) | 2.73344949 |
| 33 | Abnormal glycosylation (HP:0012345) | 2.73344949 |
| 34 | Premature graying of hair (HP:0002216) | 2.73304698 |
| 35 | Reduced antithrombin III activity (HP:0001976) | 2.71574546 |
| 36 | Type I transferrin isoform profile (HP:0003642) | 2.70063779 |
| 37 | Gastrointestinal stroma tumor (HP:0100723) | 2.68094937 |
| 38 | IgM deficiency (HP:0002850) | 2.66215318 |
| 39 | Breast hypoplasia (HP:0003187) | 2.62942723 |
| 40 | Multiple enchondromatosis (HP:0005701) | 2.62781068 |
| 41 | Sensory axonal neuropathy (HP:0003390) | 2.61402852 |
| 42 | Pancytopenia (HP:0001876) | 2.60438878 |
| 43 | Abnormality of B cell number (HP:0010975) | 2.59793349 |
| 44 | Basal cell carcinoma (HP:0002671) | 2.59329615 |
| 45 | Abnormality of the anterior horn cell (HP:0006802) | 2.58409740 |
| 46 | Degeneration of anterior horn cells (HP:0002398) | 2.58409740 |
| 47 | Irregular epiphyses (HP:0010582) | 2.57941976 |
| 48 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.53575828 |
| 49 | Increased serum lactate (HP:0002151) | 2.51994061 |
| 50 | Septate vagina (HP:0001153) | 2.49613190 |
| 51 | Increased muscle lipid content (HP:0009058) | 2.46776606 |
| 52 | Abnormal umbilical cord blood vessels (HP:0011403) | 2.45851389 |
| 53 | Single umbilical artery (HP:0001195) | 2.45851389 |
| 54 | Abnormality of the fetal cardiovascular system (HP:0010948) | 2.45851389 |
| 55 | Microretrognathia (HP:0000308) | 2.45191100 |
| 56 | Renal Fanconi syndrome (HP:0001994) | 2.43196632 |
| 57 | Cleft eyelid (HP:0000625) | 2.42690915 |
| 58 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.41958761 |
| 59 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.41797643 |
| 60 | Cerebral hypomyelination (HP:0006808) | 2.38768299 |
| 61 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.38362565 |
| 62 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.38362565 |
| 63 | Increased IgM level (HP:0003496) | 2.36568936 |
| 64 | Esophageal neoplasm (HP:0100751) | 2.36459622 |
| 65 | Neoplasm of head and neck (HP:0012288) | 2.36459622 |
| 66 | Abnormal trabecular bone morphology (HP:0100671) | 2.35584277 |
| 67 | Secondary amenorrhea (HP:0000869) | 2.35408816 |
| 68 | Mediastinal lymphadenopathy (HP:0100721) | 2.33706488 |
| 69 | Hypergonadotropic hypogonadism (HP:0000815) | 2.31719379 |
| 70 | Abnormality of T cells (HP:0002843) | 2.31296359 |
| 71 | Sparse eyelashes (HP:0000653) | 2.28798059 |
| 72 | Myelodysplasia (HP:0002863) | 2.28787043 |
| 73 | Selective tooth agenesis (HP:0001592) | 2.27448292 |
| 74 | Premature ovarian failure (HP:0008209) | 2.27070547 |
| 75 | Impaired proprioception (HP:0010831) | 2.26864299 |
| 76 | Entropion (HP:0000621) | 2.26195846 |
| 77 | Squamous cell carcinoma (HP:0002860) | 2.26173254 |
| 78 | 3-Methylglutaconic aciduria (HP:0003535) | 2.26100472 |
| 79 | Missing ribs (HP:0000921) | 2.24381473 |
| 80 | Horseshoe kidney (HP:0000085) | 2.21982873 |
| 81 | Respiratory difficulties (HP:0002880) | 2.20849216 |
| 82 | Lymphoma (HP:0002665) | 2.19415361 |
| 83 | Impaired platelet aggregation (HP:0003540) | 2.18857623 |
| 84 | Abnormal platelet function (HP:0011869) | 2.18857623 |
| 85 | Amaurosis fugax (HP:0100576) | 2.18839205 |
| 86 | Stomatitis (HP:0010280) | 2.18166860 |
| 87 | Autoimmune hemolytic anemia (HP:0001890) | 2.18097925 |
| 88 | Colon cancer (HP:0003003) | 2.17254145 |
| 89 | Ureteral duplication (HP:0000073) | 2.16994658 |
| 90 | Recurrent viral infections (HP:0004429) | 2.15181382 |
| 91 | Poikiloderma (HP:0001029) | 2.15024689 |
| 92 | Shoulder girdle muscle weakness (HP:0003547) | 2.12357358 |
| 93 | Autoimmune thrombocytopenia (HP:0001973) | 2.11325419 |
| 94 | Neoplasm of the pancreas (HP:0002894) | 2.06246212 |
| 95 | Albinism (HP:0001022) | 2.05389688 |
| 96 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.02470644 |
| 97 | Poor head control (HP:0002421) | 2.01109908 |
| 98 | Increased CSF lactate (HP:0002490) | 2.00522986 |
| 99 | Thoracolumbar scoliosis (HP:0002944) | 1.99196147 |
| 100 | Hypertensive crisis (HP:0100735) | 1.97564912 |
| 101 | Cellular immunodeficiency (HP:0005374) | 1.97518318 |
| 102 | Deep palmar crease (HP:0006191) | 1.96446678 |
| 103 | Dysphonia (HP:0001618) | 1.96249138 |
| 104 | Exercise intolerance (HP:0003546) | 1.96208981 |
| 105 | Paralysis (HP:0003470) | 1.95285335 |
| 106 | Facial hemangioma (HP:0000329) | 1.94458815 |
| 107 | Bone marrow hypocellularity (HP:0005528) | 1.93247960 |
| 108 | Patellar aplasia (HP:0006443) | 1.92266844 |
| 109 | Exertional dyspnea (HP:0002875) | 1.91911342 |
| 110 | Ependymoma (HP:0002888) | 1.91451565 |
| 111 | Cortical visual impairment (HP:0100704) | 1.88879228 |
| 112 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.88672354 |
| 113 | IgG deficiency (HP:0004315) | 1.88118001 |
| 114 | Megaloblastic anemia (HP:0001889) | 1.87777625 |
| 115 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 1.87026270 |
| 116 | Abnormality of the preputium (HP:0100587) | 1.86238201 |
| 117 | Slender long bone (HP:0003100) | 1.83839251 |
| 118 | Fatigue (HP:0012378) | 1.82740102 |
| 119 | Muscle fiber atrophy (HP:0100295) | 1.82734064 |
| 120 | Hypoplasia of the pons (HP:0012110) | 1.82692927 |
| 121 | Pulmonary fibrosis (HP:0002206) | 1.82642249 |
| 122 | Small epiphyses (HP:0010585) | 1.81966706 |
| 123 | Rhabdomyosarcoma (HP:0002859) | 1.81451547 |
| 124 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 1.81428035 |
| 125 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.79032722 |
| 126 | Abnormality of alanine metabolism (HP:0010916) | 1.79032722 |
| 127 | Hyperalaninemia (HP:0003348) | 1.79032722 |
| 128 | Asplenia (HP:0001746) | 1.79010843 |
| 129 | Upper motor neuron abnormality (HP:0002127) | 1.78548927 |
| 130 | Abnormality of the distal phalanges of the toes (HP:0010182) | 1.78492312 |
| 131 | Postnatal microcephaly (HP:0005484) | 1.76534766 |
| 132 | Cutaneous melanoma (HP:0012056) | 1.75273146 |
| 133 | Abnormality of oral frenula (HP:0000190) | 1.73979947 |
| 134 | Abnormality of the pons (HP:0007361) | 1.73806150 |
| 135 | Abnormal hemoglobin (HP:0011902) | 1.72913554 |
| 136 | Agnosia (HP:0010524) | 1.72288919 |
| 137 | Abnormality of reticulocytes (HP:0004312) | 1.71655843 |
| 138 | Mitochondrial inheritance (HP:0001427) | 1.70794690 |
| 139 | Lactic acidosis (HP:0003128) | 1.70333888 |
| 140 | Thin bony cortex (HP:0002753) | 1.70162599 |
| 141 | Recurrent bronchitis (HP:0002837) | 1.69767711 |
| 142 | Microvesicular hepatic steatosis (HP:0001414) | 1.69737100 |
| 143 | Joint stiffness (HP:0001387) | 1.69639369 |
| 144 | Diaphragmatic weakness (HP:0009113) | 1.68086787 |
| 145 | Abnormality of subcutaneous fat tissue (HP:0001001) | 1.67782875 |
| 146 | Chronic otitis media (HP:0000389) | 1.67570180 |
| 147 | Acute necrotizing encephalopathy (HP:0006965) | 1.66774705 |
| 148 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.66338596 |
| 149 | Vertebral clefting (HP:0008428) | 1.65135583 |
| 150 | Stenosis of the external auditory canal (HP:0000402) | 1.64531934 |
| 151 | Abnormality of DNA repair (HP:0003254) | 1.63750507 |
| 152 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 1.63638120 |
| 153 | Short thumb (HP:0009778) | 1.63131698 |
| 154 | Upper limb muscle weakness (HP:0003484) | 1.62820345 |
| 155 | Abnormality of the umbilical cord (HP:0010881) | 1.61801942 |
| 156 | Abnormality of the calcaneus (HP:0008364) | 1.61046886 |
| 157 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 1.59689217 |
| 158 | Petechiae (HP:0000967) | 1.59688130 |
| 159 | Absent radius (HP:0003974) | 1.59620329 |
| 160 | Aplasia/Hypoplasia of the vertebrae (HP:0008515) | 1.59347997 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | WEE1 | 4.03046336 |
| 2 | NME2 | 3.92240395 |
| 3 | BUB1 | 3.29395303 |
| 4 | PRPF4B | 2.67755800 |
| 5 | DYRK3 | 2.58302916 |
| 6 | ACVR1B | 2.45916700 |
| 7 | EIF2AK3 | 2.38144141 |
| 8 | EIF2AK1 | 2.34516909 |
| 9 | PIM2 | 2.33513242 |
| 10 | SMG1 | 2.09563041 |
| 11 | STK16 | 2.08692216 |
| 12 | CDC7 | 2.06228472 |
| 13 | RPS6KA4 | 2.03347998 |
| 14 | SCYL2 | 1.96837671 |
| 15 | FLT3 | 1.92636709 |
| 16 | BRSK2 | 1.86877996 |
| 17 | TESK2 | 1.85221625 |
| 18 | TGFBR1 | 1.80916043 |
| 19 | PBK | 1.80519444 |
| 20 | MAP4K1 | 1.79856938 |
| 21 | PASK | 1.73953714 |
| 22 | ARAF | 1.72338139 |
| 23 | MAP3K9 | 1.68361158 |
| 24 | NEK2 | 1.68136395 |
| 25 | RPS6KB2 | 1.65754131 |
| 26 | EPHA2 | 1.64655898 |
| 27 | MAP3K3 | 1.61214960 |
| 28 | TSSK6 | 1.59105425 |
| 29 | ICK | 1.56905110 |
| 30 | CDK7 | 1.56735756 |
| 31 | VRK1 | 1.55292458 |
| 32 | IRAK3 | 1.50880041 |
| 33 | SRPK1 | 1.49086502 |
| 34 | ERN1 | 1.48654376 |
| 35 | ZAP70 | 1.48479877 |
| 36 | ZAK | 1.44876560 |
| 37 | CDK19 | 1.38055698 |
| 38 | TLK1 | 1.33521840 |
| 39 | MAP3K11 | 1.31739434 |
| 40 | MAPKAPK3 | 1.23530923 |
| 41 | MKNK1 | 1.23453689 |
| 42 | MKNK2 | 1.23099713 |
| 43 | BCKDK | 1.19096912 |
| 44 | PLK1 | 1.16984509 |
| 45 | PIM1 | 1.16826197 |
| 46 | IRAK2 | 1.16261184 |
| 47 | JAK3 | 1.16227534 |
| 48 | MAP3K13 | 1.15956033 |
| 49 | EEF2K | 1.09971936 |
| 50 | MAPK11 | 1.09874195 |
| 51 | MAP3K8 | 1.08824914 |
| 52 | MATK | 1.07470168 |
| 53 | IKBKB | 1.04903744 |
| 54 | AURKB | 1.04802807 |
| 55 | TTK | 1.00384731 |
| 56 | MAP2K3 | 0.98265957 |
| 57 | TAOK1 | 0.98050675 |
| 58 | MAP2K2 | 0.97827126 |
| 59 | TEC | 0.96876776 |
| 60 | LATS2 | 0.96386053 |
| 61 | NME1 | 0.95923189 |
| 62 | SIK3 | 0.95294941 |
| 63 | CDK4 | 0.95229138 |
| 64 | ATR | 0.92186442 |
| 65 | CLK1 | 0.92018478 |
| 66 | RAF1 | 0.91904295 |
| 67 | SIK1 | 0.91626389 |
| 68 | MAP3K10 | 0.90535498 |
| 69 | CHEK2 | 0.89970724 |
| 70 | AURKA | 0.87660859 |
| 71 | KSR2 | 0.87486033 |
| 72 | STK10 | 0.87021260 |
| 73 | STK4 | 0.86891495 |
| 74 | BTK | 0.82849119 |
| 75 | TBK1 | 0.82299730 |
| 76 | CDK8 | 0.82085679 |
| 77 | MOS | 0.82015086 |
| 78 | GRK6 | 0.80965721 |
| 79 | PAK4 | 0.74604192 |
| 80 | BMPR2 | 0.73906425 |
| 81 | RPS6KA5 | 0.73503643 |
| 82 | MAPK15 | 0.73047279 |
| 83 | LRRK2 | 0.72770927 |
| 84 | MST4 | 0.72233757 |
| 85 | CHEK1 | 0.70448754 |
| 86 | MAP3K1 | 0.67291082 |
| 87 | PRKCI | 0.67234174 |
| 88 | IRAK4 | 0.66905621 |
| 89 | KIT | 0.66445804 |
| 90 | CSNK2A2 | 0.66265929 |
| 91 | CDK6 | 0.65317055 |
| 92 | BRAF | 0.64325945 |
| 93 | CSF1R | 0.63566420 |
| 94 | TXK | 0.63426423 |
| 95 | STK24 | 0.63006653 |
| 96 | BRD4 | 0.60057031 |
| 97 | MARK3 | 0.59832197 |
| 98 | KDR | 0.59446095 |
| 99 | NEK1 | 0.57642620 |
| 100 | MAP3K6 | 0.56003943 |
| 101 | TESK1 | 0.55879166 |
| 102 | CSNK2A1 | 0.50207079 |
| 103 | ILK | 0.49977238 |
| 104 | PAK1 | 0.49728390 |
| 105 | CDK2 | 0.49454886 |
| 106 | RPS6KA1 | 0.48964267 |
| 107 | IKBKE | 0.48614236 |
| 108 | CDK12 | 0.48584988 |
| 109 | IRAK1 | 0.48479754 |
| 110 | BRSK1 | 0.47989256 |
| 111 | EIF2AK2 | 0.47738101 |
| 112 | HIPK2 | 0.47583405 |
| 113 | CHUK | 0.46621649 |
| 114 | SYK | 0.46343164 |
| 115 | TAF1 | 0.45685400 |
| 116 | BLK | 0.44962530 |
| 117 | DAPK3 | 0.44917947 |
| 118 | TYK2 | 0.44292049 |
| 119 | VRK2 | 0.43794467 |
| 120 | LCK | 0.42647169 |
| 121 | CSK | 0.42089827 |
| 122 | DYRK2 | 0.41924751 |
| 123 | AKT2 | 0.40968505 |
| 124 | ERBB4 | 0.40105047 |
| 125 | NLK | 0.39483512 |
| 126 | NEK9 | 0.39014871 |
| 127 | MTOR | 0.38740984 |
| 128 | MAP3K14 | 0.35388093 |
| 129 | PAK2 | 0.35175132 |
| 130 | LYN | 0.34183338 |
| 131 | ATM | 0.33798830 |
| 132 | TRIB3 | 0.32851966 |
| 133 | ALK | 0.31905672 |
| 134 | TAOK2 | 0.31360001 |
| 135 | PDK2 | 0.30581175 |
| 136 | ABL2 | 0.30228427 |
| 137 | PKN2 | 0.30164186 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 4.68102415 |
| 2 | DNA replication_Homo sapiens_hsa03030 | 3.71064504 |
| 3 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.66658247 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 3.36085257 |
| 5 | Mismatch repair_Homo sapiens_hsa03430 | 3.17769624 |
| 6 | Protein export_Homo sapiens_hsa03060 | 2.98442513 |
| 7 | Spliceosome_Homo sapiens_hsa03040 | 2.90376863 |
| 8 | Proteasome_Homo sapiens_hsa03050 | 2.85132847 |
| 9 | RNA transport_Homo sapiens_hsa03013 | 2.70651868 |
| 10 | Base excision repair_Homo sapiens_hsa03410 | 2.30223235 |
| 11 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.27105899 |
| 12 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.23809826 |
| 13 | Homologous recombination_Homo sapiens_hsa03440 | 2.19002925 |
| 14 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.07913732 |
| 15 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.05251468 |
| 16 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.87621767 |
| 17 | Cell cycle_Homo sapiens_hsa04110 | 1.82585517 |
| 18 | Basal transcription factors_Homo sapiens_hsa03022 | 1.77475344 |
| 19 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.70039567 |
| 20 | RNA degradation_Homo sapiens_hsa03018 | 1.63065119 |
| 21 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.58266588 |
| 22 | Sulfur relay system_Homo sapiens_hsa04122 | 1.49493875 |
| 23 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 1.49096696 |
| 24 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.41427972 |
| 25 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.38573921 |
| 26 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.30763700 |
| 27 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.28142123 |
| 28 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.22364625 |
| 29 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.21391658 |
| 30 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.20274756 |
| 31 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.17415757 |
| 32 | Legionellosis_Homo sapiens_hsa05134 | 1.15847650 |
| 33 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.15128547 |
| 34 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.13679922 |
| 35 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.06782398 |
| 36 | Purine metabolism_Homo sapiens_hsa00230 | 1.06032211 |
| 37 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.03710379 |
| 38 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.95796705 |
| 39 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.92608053 |
| 40 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.91104520 |
| 41 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.90603215 |
| 42 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.86200283 |
| 43 | Alcoholism_Homo sapiens_hsa05034 | 0.85400580 |
| 44 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.83633198 |
| 45 | Prion diseases_Homo sapiens_hsa05020 | 0.82841327 |
| 46 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.81485605 |
| 47 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.77560552 |
| 48 | Measles_Homo sapiens_hsa05162 | 0.77107556 |
| 49 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.75395002 |
| 50 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.73920325 |
| 51 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.73902426 |
| 52 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.73022544 |
| 53 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.72755419 |
| 54 | Thyroid cancer_Homo sapiens_hsa05216 | 0.71697778 |
| 55 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.70942489 |
| 56 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.70417783 |
| 57 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.70253812 |
| 58 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.69965850 |
| 59 | Shigellosis_Homo sapiens_hsa05131 | 0.69151331 |
| 60 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.68592395 |
| 61 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.64795300 |
| 62 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.64413802 |
| 63 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.63578523 |
| 64 | Apoptosis_Homo sapiens_hsa04210 | 0.63409112 |
| 65 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.63244058 |
| 66 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.62512645 |
| 67 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.61822216 |
| 68 | HTLV-I infection_Homo sapiens_hsa05166 | 0.60128790 |
| 69 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.58019958 |
| 70 | Hepatitis B_Homo sapiens_hsa05161 | 0.57252458 |
| 71 | Leishmaniasis_Homo sapiens_hsa05140 | 0.56165775 |
| 72 | Parkinsons disease_Homo sapiens_hsa05012 | 0.54740243 |
| 73 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.54073367 |
| 74 | Salmonella infection_Homo sapiens_hsa05132 | 0.53855725 |
| 75 | Influenza A_Homo sapiens_hsa05164 | 0.53232225 |
| 76 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.53065510 |
| 77 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.52977062 |
| 78 | Lysosome_Homo sapiens_hsa04142 | 0.52329693 |
| 79 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.51554379 |
| 80 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.50269518 |
| 81 | Bladder cancer_Homo sapiens_hsa05219 | 0.47845440 |
| 82 | Allograft rejection_Homo sapiens_hsa05330 | 0.47427602 |
| 83 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.46990400 |
| 84 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.46907577 |
| 85 | Tuberculosis_Homo sapiens_hsa05152 | 0.44259013 |
| 86 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.44025688 |
| 87 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.44014888 |
| 88 | Hepatitis C_Homo sapiens_hsa05160 | 0.43245725 |
| 89 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.42866224 |
| 90 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.42317232 |
| 91 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.41935411 |
| 92 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.41664367 |
| 93 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.40747091 |
| 94 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.40684728 |
| 95 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.39545955 |
| 96 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.38976655 |
| 97 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.36918531 |
| 98 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.36702495 |
| 99 | Asthma_Homo sapiens_hsa05310 | 0.35858158 |
| 100 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.35318720 |
| 101 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.35006854 |
| 102 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.34090108 |
| 103 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.32667069 |
| 104 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.29788075 |
| 105 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.29302114 |
| 106 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.28500806 |
| 107 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.28445235 |
| 108 | Galactose metabolism_Homo sapiens_hsa00052 | 0.28421709 |
| 109 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.27955481 |
| 110 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.27380816 |
| 111 | Huntingtons disease_Homo sapiens_hsa05016 | 0.25793274 |
| 112 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.25458484 |
| 113 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.25014124 |
| 114 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.24827674 |
| 115 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.24694379 |
| 116 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.24620864 |
| 117 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.24212442 |
| 118 | Other glycan degradation_Homo sapiens_hsa00511 | 0.24060228 |
| 119 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.23848586 |
| 120 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.23743538 |
| 121 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.23286251 |
| 122 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.22811058 |
| 123 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.21321676 |
| 124 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.21077124 |

