YRDCP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cilium movement (GO:0003352)7.89430542
2protein localization to cilium (GO:0061512)6.38858828
3sleep (GO:0030431)6.18159909
4transepithelial transport (GO:0070633)5.74091179
5fusion of sperm to egg plasma membrane (GO:0007342)5.73664889
6high-density lipoprotein particle remodeling (GO:0034375)5.64949503
7phospholipid efflux (GO:0033700)5.50187005
8lymph vessel development (GO:0001945)5.49097814
9response to nitrosative stress (GO:0051409)5.48353662
10very-low-density lipoprotein particle assembly (GO:0034379)5.22073553
11somatic diversification of immune receptors via somatic mutation (GO:0002566)5.13774217
12somatic hypermutation of immunoglobulin genes (GO:0016446)5.13774217
13reverse cholesterol transport (GO:0043691)5.13147609
14plasma membrane fusion (GO:0045026)5.05103251
15plasma lipoprotein particle assembly (GO:0034377)5.02455422
16regulation of microtubule-based movement (GO:0060632)5.00748770
17histone mRNA catabolic process (GO:0071044)4.89133533
18adenosine metabolic process (GO:0046085)4.75508362
19regulation of triglyceride catabolic process (GO:0010896)4.49149808
20cholesterol efflux (GO:0033344)4.26042303
21histone H4-K5 acetylation (GO:0043981)4.24506673
22histone H4-K8 acetylation (GO:0043982)4.24506673
23negative regulation of complement activation (GO:0045916)4.14881316
24protein-lipid complex assembly (GO:0065005)4.06666082
25drug catabolic process (GO:0042737)4.06350436
26negative regulation of protein activation cascade (GO:2000258)3.94147432
27tolerance induction (GO:0002507)3.79212915
28xenobiotic catabolic process (GO:0042178)3.77326445
29peptide catabolic process (GO:0043171)3.72479287
30alkaloid metabolic process (GO:0009820)3.71625600
31regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.70846973
32positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.70846973
33protein-lipid complex remodeling (GO:0034368)3.63708535
34macromolecular complex remodeling (GO:0034367)3.63708535
35plasma lipoprotein particle remodeling (GO:0034369)3.63708535
36positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.57975238
37regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.57975238
38rRNA catabolic process (GO:0016075)3.57378949
39negative regulation of sterol transport (GO:0032372)3.56405766
40negative regulation of cholesterol transport (GO:0032375)3.56405766
41diterpenoid biosynthetic process (GO:0016102)3.55271123
42amino-acid betaine transport (GO:0015838)3.54597226
43carnitine transport (GO:0015879)3.54597226
44cellular response to ethanol (GO:0071361)3.54567738
45carnitine transmembrane transport (GO:1902603)3.54275476
46negative regulation of interleukin-1 beta production (GO:0032691)3.53532439
47negative regulation of fatty acid biosynthetic process (GO:0045717)3.50544200
48positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.48508839
49nodal signaling pathway (GO:0038092)3.46927835
50regulation of cholesterol esterification (GO:0010872)3.43724558
51negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.42836068
52carnitine shuttle (GO:0006853)3.41958446
53regulation of neuron projection regeneration (GO:0070570)3.40595183
54regulation of axon regeneration (GO:0048679)3.40595183
55sperm capacitation (GO:0048240)3.40531223
56multicellular organism reproduction (GO:0032504)3.39865505
57cholesterol transport (GO:0030301)3.34945798
58sterol transport (GO:0015918)3.34945798
59response to pheromone (GO:0019236)3.30602579
60rRNA methylation (GO:0031167)3.28913896
61cellular response to zinc ion (GO:0071294)3.28080302
62histone H4-K16 acetylation (GO:0043984)3.27849084
63bicarbonate transport (GO:0015701)3.23934458
64fatty acid transmembrane transport (GO:1902001)3.19318987
65acrosome assembly (GO:0001675)3.18276504
66polyol transport (GO:0015791)3.17662704
67plasma lipoprotein particle organization (GO:0071827)3.11647286
68lipoprotein transport (GO:0042953)3.11370488
69nephron epithelium morphogenesis (GO:0072088)3.09887259
70nephron tubule morphogenesis (GO:0072078)3.09887259
71C4-dicarboxylate transport (GO:0015740)3.05990523
72regulation of hippo signaling (GO:0035330)3.05872866
73negative regulation of humoral immune response (GO:0002921)3.05346626
74regulation of mRNA 3-end processing (GO:0031440)3.02486695
75mannosylation (GO:0097502)3.00562850
76regulation of germinal center formation (GO:0002634)2.97905860
77interleukin-6-mediated signaling pathway (GO:0070102)2.97114158
78positive regulation of mRNA 3-end processing (GO:0031442)2.96853470
79RNA destabilization (GO:0050779)2.96588469
80triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.92481273
81male sex determination (GO:0030238)2.89436179
82negative regulation of interleukin-1 production (GO:0032692)2.83506082
83carnitine metabolic process (GO:0009437)2.81760575
84benzene-containing compound metabolic process (GO:0042537)2.81697680
85ovulation cycle (GO:0042698)2.80445841
86sulfate transport (GO:0008272)2.79882354
87germ cell migration (GO:0008354)2.79374336
88positive regulation of mRNA catabolic process (GO:0061014)2.78807918
89regulation of skeletal muscle contraction (GO:0014819)2.78123432
90negative regulation of lipase activity (GO:0060192)2.74298707
91positive regulation of actin cytoskeleton reorganization (GO:2000251)2.71999589
92protein-lipid complex subunit organization (GO:0071825)2.70962685
93renal tubule morphogenesis (GO:0061333)2.70418753
94cAMP catabolic process (GO:0006198)2.69964226
95negative regulation of sodium ion transport (GO:0010766)2.68186752
96maturation of 5.8S rRNA (GO:0000460)2.64824560
97reproduction (GO:0000003)2.64444996
98piRNA metabolic process (GO:0034587)2.63511818
99negative regulation of protein kinase B signaling (GO:0051898)2.63126350
100glial cell proliferation (GO:0014009)2.62739311

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.62409350
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse5.01731211
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.43636329
4GBX2_23144817_ChIP-Seq_PC3_Human3.39501528
5NOTCH1_21737748_ChIP-Seq_TLL_Human2.93161685
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.63074962
7IGF1R_20145208_ChIP-Seq_DFB_Human2.26724699
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.24436935
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.20638362
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.17772086
11VDR_22108803_ChIP-Seq_LS180_Human2.10186786
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.07264991
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.06095098
14AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.02753006
15TP53_16413492_ChIP-PET_HCT116_Human1.98397468
16ZNF274_21170338_ChIP-Seq_K562_Hela1.87374999
17SMAD_19615063_ChIP-ChIP_OVARY_Human1.87241611
18TAF15_26573619_Chip-Seq_HEK293_Human1.83142892
19CBP_20019798_ChIP-Seq_JUKART_Human1.74680861
20IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.74680861
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74402626
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.73892266
23PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71401922
24FUS_26573619_Chip-Seq_HEK293_Human1.64142488
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62208850
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.57324209
27STAT3_23295773_ChIP-Seq_U87_Human1.57097855
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.54836015
29EWS_26573619_Chip-Seq_HEK293_Human1.53950890
30NR3C1_21868756_ChIP-Seq_MCF10A_Human1.50770556
31MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50084798
32ER_23166858_ChIP-Seq_MCF-7_Human1.44697741
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43521098
34P300_19829295_ChIP-Seq_ESCs_Human1.41360070
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.40825516
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.35851049
37PRDM14_20953172_ChIP-Seq_ESCs_Human1.33586381
38SMAD4_21799915_ChIP-Seq_A2780_Human1.32548656
39AR_25329375_ChIP-Seq_VCAP_Human1.29860228
40IRF1_19129219_ChIP-ChIP_H3396_Human1.29511540
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27851726
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.27614788
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25712235
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24063413
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.23091567
46TCF4_23295773_ChIP-Seq_U87_Human1.22986843
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22420878
48AHR_22903824_ChIP-Seq_MCF-7_Human1.21654420
49ESR1_21235772_ChIP-Seq_MCF-7_Human1.18898436
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.16106128
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15953726
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13495239
53TP53_22573176_ChIP-Seq_HFKS_Human1.11855764
54RUNX2_22187159_ChIP-Seq_PCA_Human1.09757469
55TP53_18474530_ChIP-ChIP_U2OS_Human1.09105574
56FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08702009
57CJUN_26792858_Chip-Seq_BT549_Human1.08547094
58OCT1_27270436_Chip-Seq_PROSTATE_Human1.08337864
59CDX2_22108803_ChIP-Seq_LS180_Human1.08317681
60NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08286627
61NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08286627
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.07734123
63BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07380450
64P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06717288
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06648576
66CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.06279960
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05095811
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.04987779
69TCF4_22108803_ChIP-Seq_LS180_Human1.03900247
70TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03801682
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03325320
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03325320
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03105005
74CDX2_20551321_ChIP-Seq_CACO-2_Human1.02767938
75ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02605728
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01750098
77GATA3_26560356_Chip-Seq_TH2_Human1.01161797
78LXR_22158963_ChIP-Seq_LIVER_Mouse0.99458066
79GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.99277829
80WDR5_24793694_ChIP-Seq_LNCAP_Human0.98802337
81NANOG_18555785_Chip-Seq_ESCs_Mouse0.98658855
82CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98479445
83EP300_21415370_ChIP-Seq_HL-1_Mouse0.98273377
84AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.98229662
85GATA3_21878914_ChIP-Seq_MCF-7_Human0.97963671
86SMAD4_21741376_ChIP-Seq_EPCs_Human0.97669945
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97280507
88CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.97108511
89KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96899832
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96554956
91SOX2_19829295_ChIP-Seq_ESCs_Human0.96525902
92NANOG_19829295_ChIP-Seq_ESCs_Human0.96525902
93FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.96171223
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95499680
95KDM2B_26808549_Chip-Seq_REH_Human0.91867003
96TAL1_26923725_Chip-Seq_HPCs_Mouse0.91664218
97FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90976550
98FOXA1_25552417_ChIP-Seq_VCAP_Human0.90318223
99PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.89788570
100PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.87719076

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat5.73833761
2MP0003195_calcinosis4.42540872
3MP0009840_abnormal_foam_cell4.13842051
4MP0003300_gastrointestinal_ulcer4.09770902
5MP0002163_abnormal_gland_morphology4.03055880
6MP0002138_abnormal_hepatobiliary_system3.83714667
7MP0010386_abnormal_urinary_bladder3.68913621
8MP0002876_abnormal_thyroid_physiology3.56320988
9MP0003252_abnormal_bile_duct2.91421811
10MP0002928_abnormal_bile_duct2.79527961
11MP0004145_abnormal_muscle_electrophysio2.70719127
12MP0002132_abnormal_respiratory_system2.51155596
13MP0005360_urolithiasis2.45809667
14MP0003283_abnormal_digestive_organ2.45047649
15MP0005379_endocrine/exocrine_gland_phen2.34597077
16MP0001879_abnormal_lymphatic_vessel2.26594861
17MP0009278_abnormal_bone_marrow2.17653510
18MP0000465_gastrointestinal_hemorrhage2.16059821
19MP0005220_abnormal_exocrine_pancreas2.15786558
20MP0005085_abnormal_gallbladder_physiolo2.13929195
21MP0002168_other_aberrant_phenotype2.11183236
22MP0000462_abnormal_digestive_system2.04430277
23MP0002089_abnormal_postnatal_growth/wei2.02947532
24MP0000383_abnormal_hair_follicle1.96397757
25MP0001270_distended_abdomen1.91022393
26MP0008872_abnormal_physiological_respon1.73807427
27MP0001984_abnormal_olfaction1.69823261
28MP0004133_heterotaxia1.62547525
29MP0003763_abnormal_thymus_physiology1.61769400
30MP0005365_abnormal_bile_salt1.60206533
31MP0002160_abnormal_reproductive_system1.57846965
32MP0004043_abnormal_pH_regulation1.54918756
33MP0003045_fibrosis1.45946907
34MP0005551_abnormal_eye_electrophysiolog1.44920154
35MP0010329_abnormal_lipoprotein_level1.44645320
36MP0001851_eye_inflammation1.44322810
37MP0004270_analgesia1.37601917
38MP0005397_hematopoietic_system_phenotyp1.29434716
39MP0001545_abnormal_hematopoietic_system1.29434716
40MP0002277_abnormal_respiratory_mucosa1.24005796
41MP0005410_abnormal_fertilization1.18094374
42MP0002734_abnormal_mechanical_nocicepti1.17419350
43MP0002233_abnormal_nose_morphology1.15868849
44MP0005395_other_phenotype1.15783246
45MP0003123_paternal_imprinting1.12107750
46MP0005332_abnormal_amino_acid1.05224204
47MP0005389_reproductive_system_phenotype1.04781423
48MP0003724_increased_susceptibility_to1.01704216
49MP0000538_abnormal_urinary_bladder1.01455618
50MP0001177_atelectasis0.98565719
51MP0001501_abnormal_sleep_pattern0.97816840
52MP0004883_abnormal_blood_vessel0.93920977
53MP0004885_abnormal_endolymph0.93288387
54MP0001666_abnormal_nutrient_absorption0.92956380
55MP0002139_abnormal_hepatobiliary_system0.90401432
56MP0004019_abnormal_vitamin_homeostasis0.90007691
57MP0005409_darkened_coat_color0.89174542
58MP0003943_abnormal_hepatobiliary_system0.88273993
59MP0002295_abnormal_pulmonary_circulatio0.85180948
60MP0005253_abnormal_eye_physiology0.84548392
61MP0000013_abnormal_adipose_tissue0.82933418
62MP0001986_abnormal_taste_sensitivity0.82469805
63MP0001968_abnormal_touch/_nociception0.80855867
64MP0010368_abnormal_lymphatic_system0.78117749
65MP0002272_abnormal_nervous_system0.78044845
66MP0004142_abnormal_muscle_tone0.77633823
67MP0002405_respiratory_system_inflammati0.77290630
68MP0000613_abnormal_salivary_gland0.73298958
69MP0004147_increased_porphyrin_level0.72778791
70MP0001664_abnormal_digestion0.72423426
71MP0002751_abnormal_autonomic_nervous0.71820493
72MP0002736_abnormal_nociception_after0.70886287
73MP0005646_abnormal_pituitary_gland0.70682531
74MP0010678_abnormal_skin_adnexa0.69003538
75MP0003656_abnormal_erythrocyte_physiolo0.69000819
76MP0001188_hyperpigmentation0.68256645
77MP0005647_abnormal_sex_gland0.66732245
78MP0010030_abnormal_orbit_morphology0.64900158
79MP0003866_abnormal_defecation0.64438437
80MP0002938_white_spotting0.64367146
81MP0001873_stomach_inflammation0.63502614
82MP0005595_abnormal_vascular_smooth0.63199974
83MP0001119_abnormal_female_reproductive0.62978979
84MP0006072_abnormal_retinal_apoptosis0.62535440
85MP0003436_decreased_susceptibility_to0.61967678
86MP0003959_abnormal_lean_body0.60994759
87MP0000372_irregular_coat_pigmentation0.60942409
88MP0001346_abnormal_lacrimal_gland0.60481861
89MP0009703_decreased_birth_body0.57814212
90MP0000609_abnormal_liver_physiology0.56647926
91MP0008569_lethality_at_weaning0.56504341
92MP0000767_abnormal_smooth_muscle0.55708895
93MP0001919_abnormal_reproductive_system0.55423574
94MP0001756_abnormal_urination0.55135574
95MP0000639_abnormal_adrenal_gland0.55035342
96MP0003828_pulmonary_edema0.50875796
97MP0003638_abnormal_response/metabolism_0.50738785
98MP0008789_abnormal_olfactory_epithelium0.49426818
99MP0001970_abnormal_pain_threshold0.49157989
100MP0003698_abnormal_male_reproductive0.48346228

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)7.16838610
2Abnormal spermatogenesis (HP:0008669)5.11365965
3Tubulointerstitial nephritis (HP:0001970)4.55029977
4Mitral stenosis (HP:0001718)4.14285000
5Abnormality of chloride homeostasis (HP:0011422)4.13713202
6Vertebral arch anomaly (HP:0008438)4.09816948
7Rectal prolapse (HP:0002035)3.98231363
8Azoospermia (HP:0000027)3.92725658
9Small epiphyses (HP:0010585)3.92650117
10Metabolic alkalosis (HP:0200114)3.90707985
11Ileus (HP:0002595)3.89909823
12Hypobetalipoproteinemia (HP:0003563)3.81413271
13Spinal muscular atrophy (HP:0007269)3.80022474
14Abnormality of the phalanges of the 2nd finger (HP:0009541)3.71356961
15Hyperlipoproteinemia (HP:0010980)3.56854155
16Stomatitis (HP:0010280)3.39733820
17Broad distal phalanx of finger (HP:0009836)3.31554141
18Abnormality of the nasal septum (HP:0000419)3.29947251
19Hypokalemic alkalosis (HP:0001949)3.29520458
20Flattened epiphyses (HP:0003071)3.23256009
21Arthropathy (HP:0003040)3.22391302
22Tubulointerstitial abnormality (HP:0001969)3.12559745
23Type II lissencephaly (HP:0007260)3.08888520
243-Methylglutaconic aciduria (HP:0003535)3.06758349
25Pancreatic cysts (HP:0001737)3.05297643
26Widely spaced teeth (HP:0000687)2.98154035
27Abnormal pancreas size (HP:0012094)2.88226394
28Depressed nasal tip (HP:0000437)2.85466657
29Hypoplasia of the capital femoral epiphysis (HP:0003090)2.77914477
30Clumsiness (HP:0002312)2.74782156
31Recurrent pneumonia (HP:0006532)2.73019807
32Abnormality of alanine metabolism (HP:0010916)2.72860503
33Hyperalaninemia (HP:0003348)2.72860503
34Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.72860503
35Cystic liver disease (HP:0006706)2.59673467
36Exocrine pancreatic insufficiency (HP:0001738)2.56715827
37Abnormality of the anterior horn cell (HP:0006802)2.55500874
38Degeneration of anterior horn cells (HP:0002398)2.55500874
39Enlarged kidneys (HP:0000105)2.48497812
40Fatigue (HP:0012378)2.34070617
41Small hand (HP:0200055)2.29660360
42Hypolipoproteinemia (HP:0010981)2.29357299
43Ulnar bowing (HP:0003031)2.25497269
44Tetany (HP:0001281)2.21942328
45Proximal amyotrophy (HP:0007126)2.20548489
46Prolonged neonatal jaundice (HP:0006579)2.17775622
47Metaphyseal dysplasia (HP:0100255)2.16642875
48Fair hair (HP:0002286)2.16617701
49Abnormality of the 2nd finger (HP:0004100)2.13154338
50Partial agenesis of the corpus callosum (HP:0001338)2.12302496
51Barrel-shaped chest (HP:0001552)2.11924652
52Irregular vertebral endplates (HP:0003301)2.10477486
53Late onset (HP:0003584)2.10295109
54Hypoplasia of the uterus (HP:0000013)2.10192316
55Abnormality of the right ventricle (HP:0001707)2.09874843
56Pulmonary fibrosis (HP:0002206)2.09386265
57Febrile seizures (HP:0002373)2.06950580
58Abnormality of the renal cortex (HP:0011035)2.03851700
59Tubulointerstitial fibrosis (HP:0005576)2.01438466
60Stomach cancer (HP:0012126)2.00745453
61Facial shape deformation (HP:0011334)1.99466752
62Potter facies (HP:0002009)1.99466752
63Gastrointestinal stroma tumor (HP:0100723)1.99116012
64Absent rod-and cone-mediated responses on ERG (HP:0007688)1.98156017
65Short femoral neck (HP:0100864)1.97630076
66Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.96499429
67Absent epiphyses (HP:0010577)1.96499429
68Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.96085220
69True hermaphroditism (HP:0010459)1.94185852
70Broad foot (HP:0001769)1.93972823
71Sensory axonal neuropathy (HP:0003390)1.93175002
72Abnormal biliary tract morphology (HP:0012440)1.92030265
73Increased circulating renin level (HP:0000848)1.91356757
74Pancreatic fibrosis (HP:0100732)1.89659709
75Type I diabetes mellitus (HP:0100651)1.88429540
76Epidermoid cyst (HP:0200040)1.85924604
77Short chin (HP:0000331)1.85256148
78Medial flaring of the eyebrow (HP:0010747)1.84947701
79Short 5th finger (HP:0009237)1.84843419
80Abnormality of the lower motor neuron (HP:0002366)1.80931065
81Cerebellar dysplasia (HP:0007033)1.79195345
82IgG deficiency (HP:0004315)1.78795538
83Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.78756121
84Congenital primary aphakia (HP:0007707)1.78645530
85Pendular nystagmus (HP:0012043)1.76195312
86Gait imbalance (HP:0002141)1.75512850
87Congenital sensorineural hearing impairment (HP:0008527)1.74748950
88Abnormality of the vertebral endplates (HP:0005106)1.74728690
89Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.74655913
90Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.74313489
91Abnormality of pyrimidine metabolism (HP:0004353)1.73731231
92Postaxial foot polydactyly (HP:0001830)1.73528386
93Alkalosis (HP:0001948)1.73086638
94Cone-rod dystrophy (HP:0000548)1.72408177
95Hypomagnesemia (HP:0002917)1.70702760
96Papillary thyroid carcinoma (HP:0002895)1.67440279
97Protruding tongue (HP:0010808)1.66503593
98Inappropriate behavior (HP:0000719)1.66281876
99Neuroendocrine neoplasm (HP:0100634)1.65600967
100Limited hip movement (HP:0008800)1.65083809

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK29.69235343
2MUSK6.17796666
3EPHA33.62602670
4PIK3CG2.73838112
5FES2.51132728
6FRK1.95642256
7PRKG21.75305994
8BMPR1B1.71548472
9MAPK111.71517505
10GRK61.71199336
11DYRK31.65030833
12AKT31.61340473
13ACVR1B1.55839085
14PASK1.35535059
15WNK41.32008562
16NME11.29211534
17NUAK11.27599514
18ZAK1.23910895
19FER1.21995145
20CASK1.16194297
21PIK3CA1.13316260
22MAP2K21.11539027
23TLK11.09447807
24NLK1.08124011
25STK391.06519720
26SGK21.06025728
27RPS6KA41.05558679
28IRAK11.05553361
29IKBKB1.04838780
30EPHB11.00590180
31MKNK20.99226898
32GRK70.96910035
33TAOK30.95672170
34PRKCE0.94708357
35WNK30.93152258
36MAP3K70.91563616
37CAMKK20.90887947
38EPHA40.77387130
39PRKCQ0.75790315
40FGFR40.75776596
41SGK4940.75038487
42SGK2230.75038487
43TESK20.71210556
44TXK0.71172759
45KIT0.70833680
46TIE10.67686397
47HIPK20.65231062
48BCKDK0.64784755
49JAK10.64272130
50FGFR20.58461809
51SIK30.58431506
52MAPK40.57794207
53PRKACG0.56509563
54ADRBK20.56265450
55TGFBR10.55483281
56MYLK0.55267430
57PRKG10.54375446
58VRK10.51614626
59ROCK10.51100514
60ITK0.50875987
61MAPK130.49790899
62MAP3K40.48982058
63PRKACB0.48899500
64BCR0.47864569
65PHKG10.46584626
66PHKG20.46584626
67INSRR0.46518624
68RPS6KA20.46038737
69SGK30.44818451
70RPS6KA50.43849480
71PAK30.43803563
72ICK0.42585666
73PRKAA10.40388215
74CDK70.39322825
75FGFR10.38711854
76MAP3K20.38372161
77PIM20.37846934
78PRKACA0.36655778
79IKBKE0.35275521
80OXSR10.34624192
81SIK10.33404961
82RPS6KA30.32815182
83MARK30.32684434
84MARK10.32407138
85CAMK40.32076742
86GSK3A0.31702688
87PIM10.31573615
88RPS6KA60.31413487
89FGFR30.30035762
90RPS6KL10.27623595
91RPS6KC10.27623595
92CSNK1D0.27138525
93CDK80.26707113
94PDGFRB0.26268079
95MAPKAPK20.25825032
96MAP4K20.25737175
97MAPK30.25489240
98MATK0.25439800
99SGK10.24808485
100RPS6KA10.24447930

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004006.57136526
2Phenylalanine metabolism_Homo sapiens_hsa003604.66985392
3Vitamin digestion and absorption_Homo sapiens_hsa049772.61093789
4Tyrosine metabolism_Homo sapiens_hsa003502.57462268
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.54427876
6Bile secretion_Homo sapiens_hsa049762.25939775
7SNARE interactions in vesicular transport_Homo sapiens_hsa041302.05325915
8Chemical carcinogenesis_Homo sapiens_hsa052042.02503023
9Non-homologous end-joining_Homo sapiens_hsa034501.99863221
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.96179107
11Linoleic acid metabolism_Homo sapiens_hsa005911.95841761
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.84898399
13Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.81210496
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.81166481
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.73943108
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.68360331
17Circadian rhythm_Homo sapiens_hsa047101.66864025
18Fat digestion and absorption_Homo sapiens_hsa049751.65923755
19ABC transporters_Homo sapiens_hsa020101.64382101
20Retinol metabolism_Homo sapiens_hsa008301.60430332
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.53989717
22Glycerophospholipid metabolism_Homo sapiens_hsa005641.50639452
23Complement and coagulation cascades_Homo sapiens_hsa046101.49094143
24beta-Alanine metabolism_Homo sapiens_hsa004101.39477057
25Glycerolipid metabolism_Homo sapiens_hsa005611.37737586
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.35036798
27Selenocompound metabolism_Homo sapiens_hsa004501.30856808
28Ether lipid metabolism_Homo sapiens_hsa005651.28351823
29Galactose metabolism_Homo sapiens_hsa000521.27779658
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.26875658
31Nicotine addiction_Homo sapiens_hsa050331.25242350
32Olfactory transduction_Homo sapiens_hsa047401.23470020
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.18171479
34Tryptophan metabolism_Homo sapiens_hsa003801.15173390
35One carbon pool by folate_Homo sapiens_hsa006701.14993882
36Mineral absorption_Homo sapiens_hsa049781.08336645
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.07314642
38Fatty acid elongation_Homo sapiens_hsa000621.05889367
39Carbohydrate digestion and absorption_Homo sapiens_hsa049731.05683776
40PPAR signaling pathway_Homo sapiens_hsa033201.05094047
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98916135
42Collecting duct acid secretion_Homo sapiens_hsa049660.97469920
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95682541
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95094992
45RNA degradation_Homo sapiens_hsa030180.89706538
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88825891
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84719668
48Pancreatic secretion_Homo sapiens_hsa049720.84013984
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80706576
50Fatty acid metabolism_Homo sapiens_hsa012120.77546164
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75193096
52cAMP signaling pathway_Homo sapiens_hsa040240.73921767
53Dorso-ventral axis formation_Homo sapiens_hsa043200.72688867
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.71491935
55Morphine addiction_Homo sapiens_hsa050320.71408262
56Nitrogen metabolism_Homo sapiens_hsa009100.69406273
57Basal transcription factors_Homo sapiens_hsa030220.65414420
58Fatty acid degradation_Homo sapiens_hsa000710.64070831
59Starch and sucrose metabolism_Homo sapiens_hsa005000.63381990
60Phototransduction_Homo sapiens_hsa047440.61921986
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.61897168
62Arachidonic acid metabolism_Homo sapiens_hsa005900.60075339
63Primary immunodeficiency_Homo sapiens_hsa053400.58562396
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57557841
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56549766
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55577429
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55196312
68Thyroid hormone synthesis_Homo sapiens_hsa049180.54504452
69Homologous recombination_Homo sapiens_hsa034400.54449248
70Amphetamine addiction_Homo sapiens_hsa050310.53811678
71N-Glycan biosynthesis_Homo sapiens_hsa005100.53174933
72Taste transduction_Homo sapiens_hsa047420.52447593
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.48148577
74Insulin resistance_Homo sapiens_hsa049310.47555108
75Arginine biosynthesis_Homo sapiens_hsa002200.46201849
76Alcoholism_Homo sapiens_hsa050340.44446401
77Glutamatergic synapse_Homo sapiens_hsa047240.43913367
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42326758
79GABAergic synapse_Homo sapiens_hsa047270.42288020
80Type II diabetes mellitus_Homo sapiens_hsa049300.41018498
81Base excision repair_Homo sapiens_hsa034100.39953317
82Glucagon signaling pathway_Homo sapiens_hsa049220.39093291
83Butanoate metabolism_Homo sapiens_hsa006500.37330720
84Vibrio cholerae infection_Homo sapiens_hsa051100.35959078
85Calcium signaling pathway_Homo sapiens_hsa040200.33545789
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33438370
87TGF-beta signaling pathway_Homo sapiens_hsa043500.32863960
88AMPK signaling pathway_Homo sapiens_hsa041520.32063650
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31954613
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30503234
91Salivary secretion_Homo sapiens_hsa049700.30379327
92Systemic lupus erythematosus_Homo sapiens_hsa053220.30113806
93Ovarian steroidogenesis_Homo sapiens_hsa049130.30049107
94Cocaine addiction_Homo sapiens_hsa050300.29951817
95Gastric acid secretion_Homo sapiens_hsa049710.29948597
96Sphingolipid metabolism_Homo sapiens_hsa006000.29880605
97Histidine metabolism_Homo sapiens_hsa003400.28085939
98Glutathione metabolism_Homo sapiens_hsa004800.27677122
99Circadian entrainment_Homo sapiens_hsa047130.26323691
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25691042

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