YTHDC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intra-S DNA damage checkpoint (GO:0031573)5.95511044
2skeletal muscle tissue regeneration (GO:0043403)5.83407498
3trophectodermal cell differentiation (GO:0001829)5.72131730
4heart trabecula morphogenesis (GO:0061384)5.68901930
5DNA integration (GO:0015074)5.32707871
6trabecula morphogenesis (GO:0061383)4.54662760
7histone H3-K4 trimethylation (GO:0080182)4.24937876
8dopamine transport (GO:0015872)4.24725421
9mitotic sister chromatid cohesion (GO:0007064)3.91686064
10transmission of nerve impulse (GO:0019226)3.75171747
11G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.61936625
12positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.61851217
13cytoplasmic mRNA processing body assembly (GO:0033962)3.60083683
14centriole replication (GO:0007099)3.59358920
15regulation of nuclear cell cycle DNA replication (GO:0033262)3.56704746
16urinary tract smooth muscle contraction (GO:0014848)3.52548395
17negative regulation of translation, ncRNA-mediated (GO:0040033)3.45924688
18regulation of translation, ncRNA-mediated (GO:0045974)3.45924688
19negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.45924688
20negative regulation of DNA-dependent DNA replication (GO:2000104)3.44425345
21viral transcription (GO:0019083)3.43513786
22kinetochore organization (GO:0051383)3.43176392
23RNA destabilization (GO:0050779)3.36767575
24positive regulation of protein kinase C signaling (GO:0090037)3.36262488
25translational termination (GO:0006415)3.31728298
26* mRNA splice site selection (GO:0006376)3.30941130
27positive regulation of skeletal muscle tissue development (GO:0048643)3.28615242
28monoubiquitinated protein deubiquitination (GO:0035520)3.27945557
29I-kappaB phosphorylation (GO:0007252)3.27683495
30alternative mRNA splicing, via spliceosome (GO:0000380)3.25962131
31kinetochore assembly (GO:0051382)3.22301558
32protein targeting to Golgi (GO:0000042)3.19765437
33establishment of protein localization to Golgi (GO:0072600)3.19312888
34receptor recycling (GO:0001881)3.17791894
35eye photoreceptor cell differentiation (GO:0001754)3.16643491
36photoreceptor cell differentiation (GO:0046530)3.16643491
37blood vessel maturation (GO:0001955)3.12864067
38toxin transport (GO:1901998)3.07786218
39peptidyl-lysine trimethylation (GO:0018023)3.07660916
40retrograde transport, vesicle recycling within Golgi (GO:0000301)3.01532011
41regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.00327766
42labyrinthine layer development (GO:0060711)2.99849897
43pre-miRNA processing (GO:0031054)2.98876497
44catecholamine transport (GO:0051937)2.93374015
45entrainment of circadian clock by photoperiod (GO:0043153)2.93209803
46DNA double-strand break processing (GO:0000729)2.89539332
47regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.88040111
48negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.87120934
49negative regulation of cell killing (GO:0031342)2.87120934
50histone H3-K9 methylation (GO:0051567)2.85674144
51regulation of fibroblast apoptotic process (GO:2000269)2.85345890
52calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.84695060
53regulation of histone H3-K9 methylation (GO:0051570)2.83958226
54regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.83864163
55histone H3-K36 demethylation (GO:0070544)2.82561208
56histone H3-K4 methylation (GO:0051568)2.82041621
57definitive hemopoiesis (GO:0060216)2.81734900
58regulation of telomere maintenance (GO:0032204)2.81394444
59embryonic retina morphogenesis in camera-type eye (GO:0060059)2.79978801
60T cell mediated immunity (GO:0002456)2.79599565
61V(D)J recombination (GO:0033151)2.78706898
62centriole assembly (GO:0098534)2.76176591
63histone H2B ubiquitination (GO:0033523)2.75918759
64production of molecular mediator involved in inflammatory response (GO:0002532)2.75439351
65diol metabolic process (GO:0034311)2.75333661
66olfactory bulb development (GO:0021772)2.75116212
67NIK/NF-kappaB signaling (GO:0038061)2.74369432
68regulation of mRNA splicing, via spliceosome (GO:0048024)2.71960321
69ER overload response (GO:0006983)2.70212426
70T cell migration (GO:0072678)2.68432943
71B cell homeostasis (GO:0001782)2.68313458
72positive regulation of histone H3-K4 methylation (GO:0051571)2.67903034
73establishment of integrated proviral latency (GO:0075713)2.67857218
74synapsis (GO:0007129)2.66861988
75leukocyte aggregation (GO:0070486)2.66786513
76regulation of mRNA processing (GO:0050684)2.66129264
77translational elongation (GO:0006414)2.66053135
78histone H3-K9 demethylation (GO:0033169)2.64970418
79spliceosomal tri-snRNP complex assembly (GO:0000244)2.62751321
80nonmotile primary cilium assembly (GO:0035058)2.62315860
81negative regulation of inclusion body assembly (GO:0090084)2.56638632
82nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.56302138
83negative regulation of NF-kappaB import into nucleus (GO:0042347)2.55862649
84histone H3-K9 modification (GO:0061647)2.55563602
85keratinocyte development (GO:0003334)2.55314494
86central nervous system myelination (GO:0022010)2.53974494
87axon ensheathment in central nervous system (GO:0032291)2.53974494
88response to folic acid (GO:0051593)2.53889002
89positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.53828969
90regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.53828969
91positive regulation of mRNA 3-end processing (GO:0031442)2.53485942
92protein K11-linked deubiquitination (GO:0035871)2.53284676
93photoperiodism (GO:0009648)2.52560714
94male meiosis I (GO:0007141)2.51756609
95macroautophagy (GO:0016236)2.50299015
96nuclear pore complex assembly (GO:0051292)2.50144214
97DNA ligation (GO:0006266)2.50049549
98regulation of mRNA 3-end processing (GO:0031440)2.49684545
99entrainment of circadian clock (GO:0009649)2.49320641
100lymphocyte migration (GO:0072676)2.49170185
101intracellular estrogen receptor signaling pathway (GO:0030520)2.48711349
102regulation of mRNA metabolic process (GO:1903311)2.48104030
103positive regulation of mRNA processing (GO:0050685)2.48052604
104embryonic camera-type eye morphogenesis (GO:0048596)2.47678821
105neuron remodeling (GO:0016322)2.45651356
106regulation of histone methylation (GO:0031060)2.45180571
107regulation of histone deacetylation (GO:0031063)2.45001060
108cellular protein complex disassembly (GO:0043624)2.44849256
109microtubule depolymerization (GO:0007019)2.42517715
110regulation of centriole replication (GO:0046599)2.42384803
111sister chromatid cohesion (GO:0007062)2.41588449
112meiotic chromosome segregation (GO:0045132)2.41566004
113retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.40944675
114cellular response to interleukin-15 (GO:0071350)2.40534495
115pattern specification involved in kidney development (GO:0061004)2.39577816
116regulation of DNA endoreduplication (GO:0032875)2.38797472
117regulation of histone H3-K4 methylation (GO:0051569)2.38784024
118ribosome assembly (GO:0042255)2.38408348
119peptide transport (GO:0015833)2.38274604
120regulation of neuron projection regeneration (GO:0070570)2.38098085
121regulation of axon regeneration (GO:0048679)2.38098085
122germinal center formation (GO:0002467)2.37911347
123ribosomal small subunit biogenesis (GO:0042274)2.36409037
124DNA-dependent DNA replication (GO:0006261)2.36134078
125regulation of RNA splicing (GO:0043484)2.35320483
126fusion of sperm to egg plasma membrane (GO:0007342)2.34908151
127positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.33859308
128protein complex disassembly (GO:0043241)2.33124964
129positive regulation of mRNA metabolic process (GO:1903313)2.32874880
130negative regulation of oligodendrocyte differentiation (GO:0048715)2.32666067
131positive regulation of histone methylation (GO:0031062)2.32616467
132sphingoid metabolic process (GO:0046519)2.32224448
133phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.31693297
134activated T cell proliferation (GO:0050798)2.31113745
135Peyers patch development (GO:0048541)2.30798914
136mucosal-associated lymphoid tissue development (GO:0048537)2.30798914
137regulation of helicase activity (GO:0051095)2.30656578
138positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.30509764
139regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.30509764
140nucleus organization (GO:0006997)2.30181815
141cell fate commitment involved in formation of primary germ layer (GO:0060795)2.29191155
142maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.27853613
143glycerophospholipid catabolic process (GO:0046475)2.25421219
144regulation of histone H3-K27 methylation (GO:0061085)2.25023251
145regulation of RNA export from nucleus (GO:0046831)2.23953869
146negative regulation of T cell mediated immunity (GO:0002710)2.21491086
147nuclear pore organization (GO:0006999)2.17977088
148positive regulation by host of viral transcription (GO:0043923)2.17608519
149long-chain fatty acid biosynthetic process (GO:0042759)2.17311330
150regulation of meiosis I (GO:0060631)2.16254868
151positive regulation of granulocyte differentiation (GO:0030854)2.14534034
152modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)2.14367178
153face development (GO:0060324)2.11561934
154microtubule polymerization or depolymerization (GO:0031109)2.11103418
155modulation by host of viral transcription (GO:0043921)2.10901320
156modulation by host of symbiont transcription (GO:0052472)2.10901320
157negative regulation by host of viral transcription (GO:0043922)2.10634935
158ncRNA catabolic process (GO:0034661)2.10056902
159histone lysine methylation (GO:0034968)2.09387069
160negative regulation of histone methylation (GO:0031061)2.09169334
161positive regulation of mRNA catabolic process (GO:0061014)2.08879800
162DNA alkylation (GO:0006305)2.08640164
163DNA methylation (GO:0006306)2.08640164
164regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.08478390
165forebrain neuron differentiation (GO:0021879)2.06903211
166response to X-ray (GO:0010165)2.06671615
167DNA damage response, detection of DNA damage (GO:0042769)2.06608773
168negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.06423120
169transcription elongation from RNA polymerase I promoter (GO:0006362)2.06105313
170regulation of chromatin silencing (GO:0031935)2.05649168
171megakaryocyte development (GO:0035855)2.05375164
172histone H4-K12 acetylation (GO:0043983)2.04948611
173DNA strand renaturation (GO:0000733)2.03871107
174replication fork processing (GO:0031297)2.03841393
175positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.03746231
176negative regulation of mRNA processing (GO:0050686)2.03711951
177developmental pigmentation (GO:0048066)2.03706722
178DNA synthesis involved in DNA repair (GO:0000731)2.03007540
179antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)13.9675972
180antigen processing and presentation of endogenous peptide antigen (GO:0002483)12.9518961
181antigen processing and presentation of endogenous antigen (GO:0019883)10.8620542
182maturation of SSU-rRNA (GO:0030490)10.4542548

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.27203141
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.88463891
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.11392511
4TP63_19390658_ChIP-ChIP_HaCaT_Human3.10960779
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.67076517
6VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.59711226
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.52815075
8TAF15_26573619_Chip-Seq_HEK293_Human2.45322601
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.44955022
10FUS_26573619_Chip-Seq_HEK293_Human2.43923951
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.38236188
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.38236188
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.38236188
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.30252336
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.29022574
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.27899275
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.20951317
18PCGF2_27294783_Chip-Seq_NPCs_Mouse2.20874306
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.18086509
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14957651
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.13874366
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.05298427
23EWS_26573619_Chip-Seq_HEK293_Human2.04333693
24CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.00259888
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.99344018
26POU5F1_16153702_ChIP-ChIP_HESCs_Human1.93078894
27SUZ12_27294783_Chip-Seq_NPCs_Mouse1.92317521
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86382852
29NFE2_27457419_Chip-Seq_LIVER_Mouse1.86196852
30MYB_26560356_Chip-Seq_TH2_Human1.85854956
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.84395843
32GBX2_23144817_ChIP-Seq_PC3_Human1.82387019
33SOX2_18555785_ChIP-Seq_MESCs_Mouse1.81242402
34PKCTHETA_26484144_Chip-Seq_BREAST_Human1.80204628
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78376225
36* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.78130895
37FOXM1_23109430_ChIP-Seq_U2OS_Human1.73941002
38ELK1_19687146_ChIP-ChIP_HELA_Human1.73517426
39EZH2_22144423_ChIP-Seq_EOC_Human1.73158912
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.69517387
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.69260122
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66831210
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.63416657
44TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.63245595
45NANOG_18555785_Chip-Seq_ESCs_Mouse1.62999170
46STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.61687167
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60573369
48ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.58050068
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.57842954
50IRF1_19129219_ChIP-ChIP_H3396_Human1.54880596
51TP53_18474530_ChIP-ChIP_U2OS_Human1.52628680
52EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.51499963
53E2F1_18555785_Chip-Seq_ESCs_Mouse1.49815325
54MYB_26560356_Chip-Seq_TH1_Human1.48942638
55BP1_19119308_ChIP-ChIP_Hs578T_Human1.48350896
56TP53_16413492_ChIP-PET_HCT116_Human1.48186957
57HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.42480937
58SUZ12_18555785_Chip-Seq_ESCs_Mouse1.41573012
59CBP_20019798_ChIP-Seq_JUKART_Human1.40451210
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40451210
61CMYC_18555785_Chip-Seq_ESCs_Mouse1.39242466
62P300_19829295_ChIP-Seq_ESCs_Human1.39232130
63FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.38546976
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38418910
65P53_22387025_ChIP-Seq_ESCs_Mouse1.33566263
66IRF8_21731497_ChIP-ChIP_J774_Mouse1.33549413
67EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.33515172
68P300_18555785_Chip-Seq_ESCs_Mouse1.32749379
69BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32083605
70TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.30850525
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30613247
72RNF2_27304074_Chip-Seq_NSC_Mouse1.30087376
73TCF7_22412390_ChIP-Seq_EML_Mouse1.30078285
74STAT3_18555785_Chip-Seq_ESCs_Mouse1.29644343
75OCT4_18555785_Chip-Seq_ESCs_Mouse1.29041813
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26794283
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26794283
78VDR_22108803_ChIP-Seq_LS180_Human1.26720744
79IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26163802
80WT1_19549856_ChIP-ChIP_CCG9911_Human1.25901634
81WDR5_24793694_ChIP-Seq_LNCAP_Human1.24993804
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.24724552
83SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.23166446
84RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.22920569
85CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22233283
86NMYC_18555785_Chip-Seq_ESCs_Mouse1.21560261
87TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20943457
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20709022
89KLF4_18555785_Chip-Seq_ESCs_Mouse1.20333072
90ER_23166858_ChIP-Seq_MCF-7_Human1.19585254
91RUNX1_27457419_Chip-Seq_LIVER_Mouse1.18427112
92GATA3_26560356_Chip-Seq_TH2_Human1.18336991
93TP53_22573176_ChIP-Seq_HFKS_Human1.17933132
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17284112
95TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16538427
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15803276
97STAT3_23295773_ChIP-Seq_U87_Human1.15592407
98FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.15342120
99PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15146906
100UTX_26944678_Chip-Seq_JUKART_Human1.14618298
101SMAD3_21741376_ChIP-Seq_EPCs_Human1.13187553
102E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.13133635
103GATA3_27048872_Chip-Seq_THYMUS_Human1.12711307
104FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12090733
105ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11937331
106FLI1_21867929_ChIP-Seq_TH2_Mouse1.11760229
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11010592
108ZFX_18555785_Chip-Seq_ESCs_Mouse1.10861492
109SOX2_18555785_Chip-Seq_ESCs_Mouse1.10677787
110ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10619799
111P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10194471
112CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09641953
113* SMAD4_21799915_ChIP-Seq_A2780_Human1.09306623
114* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07567113
115CBX2_27304074_Chip-Seq_ESCs_Mouse1.07558838
116SMAD1_18555785_Chip-Seq_ESCs_Mouse1.07265902
117ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06247129
118PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06229197
119SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03905578
120TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01616343
121RXR_22108803_ChIP-Seq_LS180_Human1.01600871
122TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01548944
123GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.01467150
124ESRRB_18555785_Chip-Seq_ESCs_Mouse1.01276218
125MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00747978
126SCL_19346495_ChIP-Seq_HPC-7_Human1.00385873
127TAL1_26923725_Chip-Seq_HPCs_Mouse0.98670442
128PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98334196
129FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97582759
130AR_21572438_ChIP-Seq_LNCaP_Human0.97383251
131CTCF_18555785_Chip-Seq_ESCs_Mouse0.96917764
132OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96404561
133STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95944768
134PU1_27457419_Chip-Seq_LIVER_Mouse0.95301185
135GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95078207
136CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94821201
137* PIAS1_25552417_ChIP-Seq_VCAP_Human0.94384743
138YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93519763
139SOX2_16153702_ChIP-ChIP_HESCs_Human0.93281240
140MAF_26560356_Chip-Seq_TH1_Human0.93084362
141ZNF274_21170338_ChIP-Seq_K562_Hela0.92700321
142RUNX_20019798_ChIP-Seq_JUKART_Human0.92409490
143CRX_20693478_ChIP-Seq_RETINA_Mouse0.92214115
144UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91011014
145TCF4_23295773_ChIP-Seq_U87_Human0.90626350
146AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90347045
147TCF4_18268006_ChIP-ChIP_LS174T_Human0.89897820
148IGF1R_20145208_ChIP-Seq_DFB_Human0.89652878
149TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89331760
150SALL4_22934838_ChIP-ChIP_CD34+_Human0.88790069
151VDR_24787735_ChIP-Seq_THP-1_Human0.88461085
152ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.88289785
153TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87578835
154TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87238058
155NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.87088275
156SMRT_27268052_Chip-Seq_Bcells_Human0.86039999
157NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85822536
158TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85340014
159MYC_22102868_ChIP-Seq_BL_Human0.85243768

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.62182471
2MP0002138_abnormal_hepatobiliary_system5.28716052
3MP0008057_abnormal_DNA_replication4.39785942
4MP0010234_abnormal_vibrissa_follicle4.04388709
5MP0001529_abnormal_vocalization3.92985113
6MP0003787_abnormal_imprinting3.39858290
7MP0008877_abnormal_DNA_methylation3.11141762
8MP0000569_abnormal_digit_pigmentation2.80538106
9MP0005409_darkened_coat_color2.71556875
10MP0001348_abnormal_lacrimal_gland2.53632704
11MP0003195_calcinosis2.41138171
12MP0005310_abnormal_salivary_gland2.36763561
13MP0001188_hyperpigmentation2.36108151
14MP0003941_abnormal_skin_development2.28955799
15MP0006292_abnormal_olfactory_placode2.26455737
16MP0009379_abnormal_foot_pigmentation2.12026264
17MP0000566_synostosis2.08073504
18MP0004381_abnormal_hair_follicle2.03732901
19MP0008058_abnormal_DNA_repair1.89958813
20MP0002796_impaired_skin_barrier1.89549703
21MP0003136_yellow_coat_color1.86347672
22MP0010094_abnormal_chromosome_stability1.82019998
23MP0003121_genomic_imprinting1.78056102
24MP0003936_abnormal_reproductive_system1.71048921
25MP0002928_abnormal_bile_duct1.64914131
26MP0002277_abnormal_respiratory_mucosa1.64726039
27MP0000627_abnormal_mammary_gland1.63630312
28MP0002009_preneoplasia1.63605155
29MP0004742_abnormal_vestibular_system1.56765936
30MP0003937_abnormal_limbs/digits/tail_de1.56138775
31MP0005174_abnormal_tail_pigmentation1.52951712
32MP0008995_early_reproductive_senescence1.49046753
33MP0000383_abnormal_hair_follicle1.47362449
34MP0005410_abnormal_fertilization1.47323132
35MP0003763_abnormal_thymus_physiology1.47119190
36MP0003077_abnormal_cell_cycle1.39416638
37MP0002938_white_spotting1.33379696
38MP0003111_abnormal_nucleus_morphology1.30720262
39MP0003698_abnormal_male_reproductive1.30232397
40MP0008961_abnormal_basal_metabolism1.28892007
41MP0005171_absent_coat_pigmentation1.28308643
42MP0001784_abnormal_fluid_regulation1.27667292
43MP0003315_abnormal_perineum_morphology1.27129627
44MP0003880_abnormal_central_pattern1.26622767
45MP0003693_abnormal_embryo_hatching1.25678311
46MP0000703_abnormal_thymus_morphology1.23329429
47MP0000516_abnormal_urinary_system1.19238613
48MP0005367_renal/urinary_system_phenotyp1.19238613
49MP0001986_abnormal_taste_sensitivity1.16948019
50MP0009278_abnormal_bone_marrow1.16165923
51MP0010678_abnormal_skin_adnexa1.15626577
52MP0008007_abnormal_cellular_replicative1.15470094
53MP0004145_abnormal_muscle_electrophysio1.13495082
54MP0006054_spinal_hemorrhage1.12776031
55MP0002396_abnormal_hematopoietic_system1.12348721
56MP0001485_abnormal_pinna_reflex1.10476325
57MP0001286_abnormal_eye_development1.10281433
58MP0003786_premature_aging1.09383377
59MP0001502_abnormal_circadian_rhythm1.08476310
60MP0002102_abnormal_ear_morphology1.04787815
61MP0000858_altered_metastatic_potential1.04194614
62MP0000778_abnormal_nervous_system1.03942324
63MP0001800_abnormal_humoral_immune1.02792055
64MP0000432_abnormal_head_morphology1.01960858
65MP0010155_abnormal_intestine_physiology1.00877179
66MP0005389_reproductive_system_phenotype1.00327609
67MP0002166_altered_tumor_susceptibility1.00076384
68MP0000750_abnormal_muscle_regeneration0.98956624
69MP0002127_abnormal_cardiovascular_syste0.98135491
70MP0002163_abnormal_gland_morphology0.97568248
71MP0001293_anophthalmia0.97082327
72MP0001919_abnormal_reproductive_system0.96339464
73MP0006072_abnormal_retinal_apoptosis0.94982035
74MP0000689_abnormal_spleen_morphology0.93943774
75MP0002095_abnormal_skin_pigmentation0.93200977
76MP0005379_endocrine/exocrine_gland_phen0.93189848
77MP0002210_abnormal_sex_determination0.92837297
78MP0005025_abnormal_response_to0.92448741
79MP0002998_abnormal_bone_remodeling0.92361328
80MP0001853_heart_inflammation0.91475600
81MP0005075_abnormal_melanosome_morpholog0.91353515
82MP0003755_abnormal_palate_morphology0.90345023
83MP0003890_abnormal_embryonic-extraembry0.89184370
84MP0000049_abnormal_middle_ear0.88936674
85MP0003828_pulmonary_edema0.88795450
86MP0001486_abnormal_startle_reflex0.87530626
87MP0002233_abnormal_nose_morphology0.87109799
88MP0005671_abnormal_response_to0.86509221
89MP0000613_abnormal_salivary_gland0.85361658
90MP0002398_abnormal_bone_marrow0.85176912
91MP0001905_abnormal_dopamine_level0.85116602
92MP0003448_altered_tumor_morphology0.85017253
93MP0002429_abnormal_blood_cell0.84644118
94MP0002751_abnormal_autonomic_nervous0.84159919
95MP0002419_abnormal_innate_immunity0.83921296
96MP0004924_abnormal_behavior0.83873426
97MP0005386_behavior/neurological_phenoty0.83873426
98MP0005387_immune_system_phenotype0.83463935
99MP0001790_abnormal_immune_system0.83463935
100MP0004808_abnormal_hematopoietic_stem0.83201362
101MP0001873_stomach_inflammation0.82982041
102MP0003252_abnormal_bile_duct0.82778248
103MP0000015_abnormal_ear_pigmentation0.82767403
104MP0003938_abnormal_ear_development0.82762553
105MP0008789_abnormal_olfactory_epithelium0.82450938
106MP0002723_abnormal_immune_serum0.82329858
107MP0002420_abnormal_adaptive_immunity0.81624721
108MP0002452_abnormal_antigen_presenting0.80588291
109MP0000462_abnormal_digestive_system0.79548362
110MP0001819_abnormal_immune_cell0.79485801
111MP0005000_abnormal_immune_tolerance0.79470152
112MP0005423_abnormal_somatic_nervous0.78819078
113MP0000631_abnormal_neuroendocrine_gland0.78606313
114MP0002249_abnormal_larynx_morphology0.78538454
115MP0004957_abnormal_blastocyst_morpholog0.77480636
116MP0000653_abnormal_sex_gland0.77232186
117MP0000762_abnormal_tongue_morphology0.77230028
118MP0002177_abnormal_outer_ear0.77214239
119MP0002653_abnormal_ependyma_morphology0.76918710
120MP0000026_abnormal_inner_ear0.76000739
121MP0002098_abnormal_vibrissa_morphology0.75283210
122MP0001984_abnormal_olfaction0.73558806
123MP0001929_abnormal_gametogenesis0.73536349
124MP0008932_abnormal_embryonic_tissue0.73244314
125MP0002132_abnormal_respiratory_system0.72587576
126MP0001119_abnormal_female_reproductive0.72245390
127MP0001851_eye_inflammation0.71634535
128MP0005499_abnormal_olfactory_system0.71562705
129MP0005394_taste/olfaction_phenotype0.71562705
130MP0001145_abnormal_male_reproductive0.71274108
131MP0002160_abnormal_reproductive_system0.71068553
132MP0000920_abnormal_myelination0.70924958
133MP0005076_abnormal_cell_differentiation0.70571143
134MP0001340_abnormal_eyelid_morphology0.70427078
135MP0002752_abnormal_somatic_nervous0.69929708
136MP0005623_abnormal_meninges_morphology0.69587753
137MP0000685_abnormal_immune_system0.69567972
138MP0005501_abnormal_skin_physiology0.69515177
139MP0000716_abnormal_immune_system0.69400835
140MP0004885_abnormal_endolymph0.69308989
141MP0003567_abnormal_fetal_cardiomyocyte0.68970135
142MP0000733_abnormal_muscle_development0.68769077
143MP0002161_abnormal_fertility/fecundity0.68350388
144MP0002405_respiratory_system_inflammati0.68180121
145MP0005377_hearing/vestibular/ear_phenot0.68125552
146MP0003878_abnormal_ear_physiology0.68125552
147MP0002006_tumorigenesis0.67702701
148MP0002114_abnormal_axial_skeleton0.66861856
149MP0003221_abnormal_cardiomyocyte_apopto0.66747509
150MP0003950_abnormal_plasma_membrane0.66682576
151MP0000427_abnormal_hair_cycle0.65789182
152MP0003861_abnormal_nervous_system0.65401659
153MP0002722_abnormal_immune_system0.65139081
154MP0000490_abnormal_crypts_of0.64268092
155MP0009703_decreased_birth_body0.63808899
156MP0004142_abnormal_muscle_tone0.61125196

Predicted human phenotypes

RankGene SetZ-score
1Nasal polyposis (HP:0100582)9.99839956
2Chronic sinusitis (HP:0011109)8.47762162
3Abnormality of the nasal mucosa (HP:0000433)7.93466009
4Recurrent bronchitis (HP:0002837)7.31514682
5Hypothermia (HP:0002045)6.60118230
6Bronchitis (HP:0012387)4.74836621
7Abnormal rod and cone electroretinograms (HP:0008323)4.35377544
8Enlarged epiphyses (HP:0010580)3.71360528
9Bony spicule pigmentary retinopathy (HP:0007737)3.59736989
10Emphysema (HP:0002097)3.49132704
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.47816962
12Thick nail (HP:0001805)3.44948947
13Thickened helices (HP:0000391)3.44243238
14Chromsome breakage (HP:0040012)3.42268697
15Ectopia lentis (HP:0001083)3.39176716
16Pustule (HP:0200039)3.36994577
17Exotropia (HP:0000577)3.30667517
18Absent rod-and cone-mediated responses on ERG (HP:0007688)3.22784899
19Recurrent bacterial skin infections (HP:0005406)3.13602858
20Volvulus (HP:0002580)3.10136223
21Abnormal ciliary motility (HP:0012262)3.04259671
22Deep palmar crease (HP:0006191)2.97620360
23Duplicated collecting system (HP:0000081)2.96808104
24Ectopic kidney (HP:0000086)2.96059479
25Alveolar cell carcinoma (HP:0006519)2.75922568
26Abnormality of the renal collecting system (HP:0004742)2.74116074
27Thyroiditis (HP:0100646)2.66859925
28Abnormal respiratory motile cilium physiology (HP:0012261)2.66679043
29Global brain atrophy (HP:0002283)2.65010849
30Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.63831196
31Aplasia cutis congenita (HP:0001057)2.59772499
32Impulsivity (HP:0100710)2.59015801
33Supernumerary ribs (HP:0005815)2.56815534
34Slow-growing hair (HP:0002217)2.56291914
35Abnormality of hair growth rate (HP:0011363)2.56291914
36Flattened epiphyses (HP:0003071)2.54716279
37Supernumerary bones of the axial skeleton (HP:0009144)2.54174967
38Stomach cancer (HP:0012126)2.53475928
39Lip pit (HP:0100267)2.52793404
40Prostate neoplasm (HP:0100787)2.42233279
41Aplasia/Hypoplasia of the earlobes (HP:0009906)2.40845183
42Papilledema (HP:0001085)2.35954704
43Clumsiness (HP:0002312)2.33204414
44Parakeratosis (HP:0001036)2.30145843
45Abnormal respiratory motile cilium morphology (HP:0005938)2.27870755
46Abnormal respiratory epithelium morphology (HP:0012253)2.27870755
47Sparse scalp hair (HP:0002209)2.25649799
48Genetic anticipation (HP:0003743)2.23961797
49Abnormality of the nasal septum (HP:0000419)2.19157636
50Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.18731603
51Abnormality of the incisor (HP:0000676)2.17751199
52Postural instability (HP:0002172)2.16776036
53Abnormal hair whorl (HP:0010721)2.16075713
54T lymphocytopenia (HP:0005403)2.16045468
55Abnormality of incisor morphology (HP:0011063)2.15767253
56Recurrent abscess formation (HP:0002722)2.15589723
57Acute lymphatic leukemia (HP:0006721)2.14987187
58Abnormality of the fingertips (HP:0001211)2.12498471
59Constricted visual fields (HP:0001133)2.10105431
60Severe combined immunodeficiency (HP:0004430)2.06438995
61Chronic diarrhea (HP:0002028)2.02286789
62Abnormality of the preputium (HP:0100587)2.02208336
63Thyroid-stimulating hormone excess (HP:0002925)2.01062905
64Abnormality of T cell number (HP:0011839)2.01041645
65Absent radius (HP:0003974)2.00093329
66Abnormality of DNA repair (HP:0003254)2.00030318
67Chronic otitis media (HP:0000389)13.8235153
68Premature loss of primary teeth (HP:0006323)1.98718409
69Abnormal number of incisors (HP:0011064)1.98236325
70Oligodactyly (hands) (HP:0001180)1.96966284
71Chin dimple (HP:0010751)1.95744291
72Abnormality of chromosome stability (HP:0003220)1.95125681
73Absent/shortened dynein arms (HP:0200106)1.93772635
74Dynein arm defect of respiratory motile cilia (HP:0012255)1.93772635
75White forelock (HP:0002211)1.93276743
76Supernumerary spleens (HP:0009799)1.91761888
77Abnormality of the columella (HP:0009929)1.91152211
7811 pairs of ribs (HP:0000878)1.90087267
79Meckel diverticulum (HP:0002245)1.90038387
80Cubitus valgus (HP:0002967)1.89849407
81Absent forearm bone (HP:0003953)1.89387796
82Aplasia involving forearm bones (HP:0009822)1.89387796
83Rhinitis (HP:0012384)1.88760897
84Granulocytopenia (HP:0001913)1.87513916
85Panhypogammaglobulinemia (HP:0003139)1.86835629
86Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.85945186
87Abnormality of the parietal bone (HP:0002696)1.84682129
88Abnormality of the labia minora (HP:0012880)1.84161618
89Asplenia (HP:0001746)1.83949231
90Increased IgE level (HP:0003212)1.83676194
91Cupped ear (HP:0000378)1.83146096
92Abnormality of secondary sexual hair (HP:0009888)1.82803731
93Abnormality of the axillary hair (HP:0100134)1.82803731
94Amelogenesis imperfecta (HP:0000705)1.80502000
95Abnormality of the alveolar ridges (HP:0006477)1.79431433
96Abnormality of eosinophils (HP:0001879)1.79369398
97Patchy hypopigmentation of hair (HP:0011365)1.77961251
98Aplasia/Hypoplasia of the uvula (HP:0010293)1.77532517
99Oligodactyly (HP:0012165)1.77477886
100Reticulocytopenia (HP:0001896)1.74290543
101Anal stenosis (HP:0002025)1.73785747
102Gastroesophageal reflux (HP:0002020)1.73559273
103Esophageal atresia (HP:0002032)1.73459697
104Recurrent skin infections (HP:0001581)1.72556466
105Neoplasm of the tracheobronchial system (HP:0100552)1.71543660
106Asymmetry of the thorax (HP:0001555)1.70644331
107Nephronophthisis (HP:0000090)1.70383515
108Clubbing of toes (HP:0100760)1.70362905
109Abnormality of the ileum (HP:0001549)1.69724551
110Abnormality of the antihelix (HP:0009738)1.67329550
111Neurofibrillary tangles (HP:0002185)1.66683781
112Abnormality of the epiphysis of the femoral head (HP:0010574)1.66440556
113Dysdiadochokinesis (HP:0002075)1.64820820
114B lymphocytopenia (HP:0010976)1.64482470
115Abnormality of B cell number (HP:0010975)1.64482470
116Eczematoid dermatitis (HP:0000976)1.64227077
117Septo-optic dysplasia (HP:0100842)1.64215240
118Acute myeloid leukemia (HP:0004808)1.63373756
119Joint swelling (HP:0001386)1.63162938
120Duplication of thumb phalanx (HP:0009942)1.62825945
121Aplasia/Hypoplasia of the spleen (HP:0010451)1.62738381
122Progressive external ophthalmoplegia (HP:0000590)1.62528693
123Gingivitis (HP:0000230)1.61987157
124Intestinal atresia (HP:0011100)1.61896045
125Conical tooth (HP:0000698)1.60985207
126Long eyelashes (HP:0000527)1.60404630
127Metaphyseal cupping (HP:0003021)1.59278018
128Palmar hyperkeratosis (HP:0010765)1.59251313
129Abnormality of the femoral head (HP:0003368)1.59176089
130Attenuation of retinal blood vessels (HP:0007843)1.59174550
131Medulloblastoma (HP:0002885)1.58563329
132Decreased central vision (HP:0007663)1.58210082
133Bronchiectasis (HP:0002110)1.58171312
134Myelodysplasia (HP:0002863)1.58144989
135Intestinal fistula (HP:0100819)1.58138471
136Periodontitis (HP:0000704)1.57700582
137Impaired smooth pursuit (HP:0007772)1.57535188
138Abolished electroretinogram (ERG) (HP:0000550)1.57389874
139Palmoplantar hyperkeratosis (HP:0000972)1.56357650
140Abnormality of the septum pellucidum (HP:0007375)1.55833440
141Colon cancer (HP:0003003)1.54742015
142Overfolded helix (HP:0000396)1.52604240
143Absent thumb (HP:0009777)1.51863945
144Abnormality of the renal medulla (HP:0100957)1.50830916
145Type 2 muscle fiber atrophy (HP:0003554)1.50826886
146Birth length less than 3rd percentile (HP:0003561)1.50643361
147Abnormality of femoral epiphyses (HP:0006499)1.50615133
148Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.50615133
149Abnormality of the nasolacrimal system (HP:0000614)1.50445685
150Agammaglobulinemia (HP:0004432)1.50351648
151Recurrent sinusitis (HP:0011108)1.49538202
152Horseshoe kidney (HP:0000085)1.49354757
153Neurodegeneration (HP:0002180)1.48761580
154Abnormality of the phalanges of the 2nd finger (HP:0009541)1.48473618
155Protruding tongue (HP:0010808)1.47916337
156Neoplasm of the oral cavity (HP:0100649)1.47582341
157Rib fusion (HP:0000902)1.47468001
158Depressed nasal tip (HP:0000437)1.47416579
159Absent frontal sinuses (HP:0002688)1.47401206
160Eosinophilia (HP:0001880)1.46848773
161Abnormality of the vertebral endplates (HP:0005106)1.46233602
162Aplasia involving bones of the extremities (HP:0009825)1.45718245
163Aplasia involving bones of the upper limbs (HP:0009823)1.45718245
164Aplasia of the phalanges of the hand (HP:0009802)1.45718245
165Fine hair (HP:0002213)1.39945310
166Abnormal pancreas size (HP:0012094)1.39369972
167Azoospermia (HP:0000027)1.38855837
168Abnormality of T cells (HP:0002843)1.37995839
169Progressive cerebellar ataxia (HP:0002073)1.37470383
170Truncal obesity (HP:0001956)1.34625554
171Personality changes (HP:0000751)1.33589131
172Hemiplegia (HP:0002301)1.33455934
1732-3 toe syndactyly (HP:0004691)1.32482270
174Broad alveolar ridges (HP:0000187)1.28287653
175Recurrent fungal infections (HP:0002841)1.27540938
176Abnormality of ocular smooth pursuit (HP:0000617)1.25018867
177EMG: neuropathic changes (HP:0003445)1.24360005
178Neoplasm of the lung (HP:0100526)1.24266201
179Hypochromic microcytic anemia (HP:0004840)1.24254172
180Neonatal hypoglycemia (HP:0001998)1.23763171
181Recurrent viral infections (HP:0004429)1.23558307

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.34409182
2TAOK33.64679439
3ARAF2.93638913
4PNCK2.91523698
5IRAK32.73128494
6SRPK12.54607831
7STK162.35167292
8BRD42.28163190
9MKNK22.21898903
10BRAF2.21196605
11CDK122.20725856
12TXK2.09819603
13PLK42.09628901
14IRAK42.09422663
15MKNK12.09391693
16MAP3K1311.4133334
17ZAK1.98316809
18MST41.95274405
19MAPK151.92589067
20CDC71.76121076
21KSR21.75278461
22SIK21.66139307
23MOS1.65810096
24VRK11.58690990
25MAP3K71.54943810
26TNIK1.52102387
27MAP3K141.51585204
28IRAK21.43563456
29IRAK11.40049646
30STK391.33978016
31KSR11.31736391
32CDK31.31370728
33GRK71.30578181
34DYRK31.22767672
35NUAK11.20751301
36CASK1.20059788
37NLK1.18712397
38BMPR1B1.18050057
39YES11.15227582
40BCR1.14797849
41ACVR1B1.14037902
42WNK11.08463229
43CLK11.07784083
44CSNK1A1L1.07157214
45RPS6KA51.05960708
46RAF11.05859732
47NEK61.05570796
48MARK11.04383821
49MAP4K11.04158015
50STK41.02752324
51STK241.02610296
52PLK30.98959321
53TEC0.95841249
54RIPK40.95814768
55AKT30.95439196
56FGFR20.95127189
57EIF2AK20.91393726
58CSNK1G10.90687749
59GRK10.90616578
60PASK0.89024364
61ADRBK20.87612515
62ATM0.87268742
63PKN10.86530698
64ILK0.86327863
65CHEK20.86264229
66BMPR20.85517410
67LATS10.83121530
68TTK0.83019344
69ATR0.81870286
70BTK0.77922077
71EPHA20.77904909
72TSSK60.76448545
73CSNK1G30.76049220
74STK30.75814806
75ERBB30.75392480
76STK38L0.74836979
77CHEK10.72425130
78ITK0.71985406
79SGK20.71511419
80FES0.69963096
81STK100.69183190
82MAPK70.68763911
83NEK20.67699556
84MAP3K80.65244849
85FGR0.63824167
86WEE10.63679208
87PBK0.63616715
88LCK0.62169536
89IKBKB0.61633267
90HIPK20.61529445
91CHUK0.61204936
92CDK90.61082809
93PIM10.59983346
94DYRK1A0.58970166
95MARK20.58875233
96MAP2K20.58823061
97FGFR30.58692382
98TLK10.57213527
99MUSK0.55939254
100HCK0.55867171
101SGK10.55405605
102CDK70.55374451
103SIK30.54999099
104CDK10.53158188
105MAP3K40.52364286
106CAMK1G0.52263999
107CDK60.51553577
108PRKCQ0.51408915
109OXSR10.51333726
110MAPKAPK50.50715713
111TNK20.50197531
112CSNK1E0.50169159
113CDK20.49986484
114PRKAA20.47826828
115RPS6KB20.47611560
116IKBKE0.47462747
117PLK10.47455536
118GRK60.47160980
119EPHA40.45971938
120CSNK1D0.45921837
121MAPK140.45858430
122LYN0.45549068
123MAP3K100.41085750
124DYRK1B0.40473132
125SGK4940.38670651
126SGK2230.38670651
127MAP3K10.38198562
128STK380.37591762
129PDK10.33480982
130MARK30.29240129
131CDK40.28040677
132JAK10.27435848
133TAOK10.26228183
134SGK30.26045336
135STK110.25127091
136TYRO30.24772136
137SYK0.23690426
138PRKCZ0.21007647
139ZAP700.18290759
140RPS6KB10.18200819
141MTOR0.17477262
142RPS6KA10.17108024
143FRK0.16909808
144GSK3B0.16197937
145PDPK10.16026639
146TYK20.15373386
147PIK3CG0.14954727
148CAMK1D0.14820084
149CSK0.13254744

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034602.34289710
2Non-homologous end-joining_Homo sapiens_hsa034502.17154839
3Spliceosome_Homo sapiens_hsa030402.13938601
4Primary immunodeficiency_Homo sapiens_hsa053401.91732121
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.86311448
6Dorso-ventral axis formation_Homo sapiens_hsa043201.73127229
7RNA polymerase_Homo sapiens_hsa030201.69663576
8Basal transcription factors_Homo sapiens_hsa030221.69567103
9Acute myeloid leukemia_Homo sapiens_hsa052211.65954074
10Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.60795811
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.60353922
12Homologous recombination_Homo sapiens_hsa034401.59445549
13RNA degradation_Homo sapiens_hsa030181.57255752
14Phototransduction_Homo sapiens_hsa047441.56379479
15Thyroid cancer_Homo sapiens_hsa052161.52820641
16Mismatch repair_Homo sapiens_hsa034301.51831866
17Chronic myeloid leukemia_Homo sapiens_hsa052201.50221310
18Ribosome_Homo sapiens_hsa030101.49037297
19Pancreatic cancer_Homo sapiens_hsa052121.43538545
20Inositol phosphate metabolism_Homo sapiens_hsa005621.40396724
21mRNA surveillance pathway_Homo sapiens_hsa030151.39964329
22Type II diabetes mellitus_Homo sapiens_hsa049301.39626983
23Transcriptional misregulation in cancer_Homo sapiens_hsa052021.34583483
24Renal cell carcinoma_Homo sapiens_hsa052111.32688393
25Nicotine addiction_Homo sapiens_hsa050331.27456441
26T cell receptor signaling pathway_Homo sapiens_hsa046601.26858769
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.25072195
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.24895143
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.21737917
30DNA replication_Homo sapiens_hsa030301.20985560
31Cell cycle_Homo sapiens_hsa041101.20433732
32Circadian rhythm_Homo sapiens_hsa047101.19044696
33Nucleotide excision repair_Homo sapiens_hsa034201.18620474
34Ether lipid metabolism_Homo sapiens_hsa005651.18297588
35Hepatitis C_Homo sapiens_hsa051601.14665428
36Long-term potentiation_Homo sapiens_hsa047201.12319172
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11707575
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.10489583
39Hematopoietic cell lineage_Homo sapiens_hsa046401.10350130
40Graft-versus-host disease_Homo sapiens_hsa053321.09719921
41Olfactory transduction_Homo sapiens_hsa047401.08960515
42RNA transport_Homo sapiens_hsa030131.07781228
43Toll-like receptor signaling pathway_Homo sapiens_hsa046201.07086658
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.05730400
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05619394
46Prolactin signaling pathway_Homo sapiens_hsa049171.05061742
47Base excision repair_Homo sapiens_hsa034101.04312742
48p53 signaling pathway_Homo sapiens_hsa041151.04284580
49MicroRNAs in cancer_Homo sapiens_hsa052061.03212144
50B cell receptor signaling pathway_Homo sapiens_hsa046621.00939531
51Autoimmune thyroid disease_Homo sapiens_hsa053201.00519889
52Systemic lupus erythematosus_Homo sapiens_hsa053220.99461014
53Sphingolipid signaling pathway_Homo sapiens_hsa040710.98621879
54Serotonergic synapse_Homo sapiens_hsa047260.98440456
55Apoptosis_Homo sapiens_hsa042100.97425120
56Measles_Homo sapiens_hsa051620.95716016
57Herpes simplex infection_Homo sapiens_hsa051680.95635084
58VEGF signaling pathway_Homo sapiens_hsa043700.95612013
59Sphingolipid metabolism_Homo sapiens_hsa006000.94088203
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93382430
61Non-small cell lung cancer_Homo sapiens_hsa052230.93215939
62Taste transduction_Homo sapiens_hsa047420.92406361
63Allograft rejection_Homo sapiens_hsa053300.91414400
64Wnt signaling pathway_Homo sapiens_hsa043100.91413721
65Epstein-Barr virus infection_Homo sapiens_hsa051690.91211083
66Type I diabetes mellitus_Homo sapiens_hsa049400.89369872
67Endometrial cancer_Homo sapiens_hsa052130.88071412
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.86681841
69Axon guidance_Homo sapiens_hsa043600.85106819
70Osteoclast differentiation_Homo sapiens_hsa043800.84261315
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83707957
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83336780
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82950789
74mTOR signaling pathway_Homo sapiens_hsa041500.80722491
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80130168
76Influenza A_Homo sapiens_hsa051640.77514391
77Long-term depression_Homo sapiens_hsa047300.76559788
78Glutamatergic synapse_Homo sapiens_hsa047240.75488993
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75338022
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74919123
81Prostate cancer_Homo sapiens_hsa052150.71113924
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.71065007
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70906584
84TGF-beta signaling pathway_Homo sapiens_hsa043500.70186567
85Basal cell carcinoma_Homo sapiens_hsa052170.69638513
86Antigen processing and presentation_Homo sapiens_hsa046120.69599010
87Viral carcinogenesis_Homo sapiens_hsa052030.69531362
88Linoleic acid metabolism_Homo sapiens_hsa005910.68111505
89HTLV-I infection_Homo sapiens_hsa051660.67846869
90MAPK signaling pathway_Homo sapiens_hsa040100.66990803
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.66746966
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66650692
93Pyrimidine metabolism_Homo sapiens_hsa002400.66294126
94Cholinergic synapse_Homo sapiens_hsa047250.65750429
95Leishmaniasis_Homo sapiens_hsa051400.65674658
96Arachidonic acid metabolism_Homo sapiens_hsa005900.64283684
97Asthma_Homo sapiens_hsa053100.64201407
98Chemokine signaling pathway_Homo sapiens_hsa040620.63716897
99African trypanosomiasis_Homo sapiens_hsa051430.63001069
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.62767178
101Morphine addiction_Homo sapiens_hsa050320.62233870
102Pathways in cancer_Homo sapiens_hsa052000.62229799
103Cocaine addiction_Homo sapiens_hsa050300.61750127
104Alcoholism_Homo sapiens_hsa050340.61460622
105Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60805668
106Amphetamine addiction_Homo sapiens_hsa050310.60596655
107GnRH signaling pathway_Homo sapiens_hsa049120.60200751
108Bladder cancer_Homo sapiens_hsa052190.59480923
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.59098996
110Hepatitis B_Homo sapiens_hsa051610.58489802
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57235181
112FoxO signaling pathway_Homo sapiens_hsa040680.56849700
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56716982
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56517091
115Toxoplasmosis_Homo sapiens_hsa051450.56346974
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56215862
117Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55543119
118Choline metabolism in cancer_Homo sapiens_hsa052310.55431028
119Ras signaling pathway_Homo sapiens_hsa040140.55208771
120Insulin resistance_Homo sapiens_hsa049310.55083219
121Protein export_Homo sapiens_hsa030600.55075414
122cAMP signaling pathway_Homo sapiens_hsa040240.54395503
123Adherens junction_Homo sapiens_hsa045200.52090519
124Rheumatoid arthritis_Homo sapiens_hsa053230.51282485
125Tight junction_Homo sapiens_hsa045300.50676068
126HIF-1 signaling pathway_Homo sapiens_hsa040660.50565882
127Malaria_Homo sapiens_hsa051440.50136250
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49383119
129Hedgehog signaling pathway_Homo sapiens_hsa043400.49139833
130Small cell lung cancer_Homo sapiens_hsa052220.49001908
131Purine metabolism_Homo sapiens_hsa002300.48985976
132Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48908800
133Glioma_Homo sapiens_hsa052140.48025301
134TNF signaling pathway_Homo sapiens_hsa046680.47839772
135Hippo signaling pathway_Homo sapiens_hsa043900.46241720
136Melanoma_Homo sapiens_hsa052180.45853340
137Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45767497
138Colorectal cancer_Homo sapiens_hsa052100.45554247
139Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45243595
140ErbB signaling pathway_Homo sapiens_hsa040120.44249663

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