YTHDC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein binds to N6-methyladenosine, a common modified RNA nucleotide that is enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. Binding of proteins to this modified nucleotide may regulate mRNA translation and stability. This gene may be associated with susceptibility to pancreatic cancer in human patients, and knockdown of this gene resulted in reduced proliferation in a human liver cancer cell line. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)7.54737839
2nuclear pore organization (GO:0006999)6.78365079
3mitotic sister chromatid cohesion (GO:0007064)5.95824494
4pore complex assembly (GO:0046931)5.47605627
5monoubiquitinated protein deubiquitination (GO:0035520)4.97222058
6presynaptic membrane assembly (GO:0097105)4.94594160
7cytoplasmic mRNA processing body assembly (GO:0033962)4.52122799
8presynaptic membrane organization (GO:0097090)4.48070720
9V(D)J recombination (GO:0033151)4.37907156
10regulation of RNA export from nucleus (GO:0046831)4.34197718
11DNA unwinding involved in DNA replication (GO:0006268)4.30143709
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.23554328
13ionotropic glutamate receptor signaling pathway (GO:0035235)3.86969897
14interkinetic nuclear migration (GO:0022027)3.85798361
15neuron cell-cell adhesion (GO:0007158)3.83359552
16cellular response to ethanol (GO:0071361)3.82462897
17dosage compensation (GO:0007549)3.80840244
18pre-miRNA processing (GO:0031054)3.76256284
19histone H3-K36 demethylation (GO:0070544)3.76156341
20sister chromatid cohesion (GO:0007062)3.71467290
21protein localization to synapse (GO:0035418)3.67060347
22positive regulation of respiratory burst (GO:0060267)3.64568835
23synaptic transmission, glutamatergic (GO:0035249)3.63673703
24regulation of DNA endoreduplication (GO:0032875)3.62641304
25Golgi to endosome transport (GO:0006895)3.60256438
26regulation of centriole replication (GO:0046599)3.59031919
27regulation of nucleobase-containing compound transport (GO:0032239)3.52235780
28DNA topological change (GO:0006265)3.45677927
29histone H3-K4 trimethylation (GO:0080182)3.42174940
30sister chromatid segregation (GO:0000819)3.40248897
31negative regulation of DNA-dependent DNA replication (GO:2000104)3.38935954
32neuron-neuron synaptic transmission (GO:0007270)3.38091716
33startle response (GO:0001964)3.37466887
34glutamate receptor signaling pathway (GO:0007215)3.36827548
35synaptic vesicle exocytosis (GO:0016079)3.36045592
36DNA duplex unwinding (GO:0032508)3.26953983
37regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.25507390
38peptidyl-tyrosine autophosphorylation (GO:0038083)3.24004628
39centrosome duplication (GO:0051298)3.23751837
40phosphorylated carbohydrate dephosphorylation (GO:0046838)3.23308442
41inositol phosphate dephosphorylation (GO:0046855)3.23308442
42negative regulation of translation, ncRNA-mediated (GO:0040033)3.22077933
43regulation of translation, ncRNA-mediated (GO:0045974)3.22077933
44negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.22077933
45positive regulation of dendritic spine morphogenesis (GO:0061003)3.21478641
46histone lysine methylation (GO:0034968)3.21418593
47vocalization behavior (GO:0071625)3.21153092
48DNA geometric change (GO:0032392)3.21144918
49mitotic nuclear envelope disassembly (GO:0007077)3.20324400
50dentate gyrus development (GO:0021542)3.19471548
51genitalia morphogenesis (GO:0035112)3.18646933
52inositol phosphate catabolic process (GO:0071545)3.18296418
53neural tube formation (GO:0001841)3.17989457
54transmission of nerve impulse (GO:0019226)3.17746542
55regulation of histone H3-K9 methylation (GO:0051570)3.17477010
56regulation of centrosome duplication (GO:0010824)3.17412570
57histone H3-K4 methylation (GO:0051568)3.15476195
58locomotory exploration behavior (GO:0035641)3.14925628
59peptidyl-lysine methylation (GO:0018022)3.12102112
60regulation of excitatory postsynaptic membrane potential (GO:0060079)3.11710463
61regulation of sister chromatid cohesion (GO:0007063)3.09757450
62regulation of dendritic spine morphogenesis (GO:0061001)3.09513644
63negative regulation of histone methylation (GO:0031061)3.09285928
64regulation of short-term neuronal synaptic plasticity (GO:0048172)3.07528217
65membrane disassembly (GO:0030397)3.07451462
66nuclear envelope disassembly (GO:0051081)3.07451462
67negative regulation of dendrite morphogenesis (GO:0050774)3.06052162
68positive regulation of histone H3-K4 methylation (GO:0051571)3.05960137
69postsynaptic membrane organization (GO:0001941)3.04657913
70long-term synaptic potentiation (GO:0060291)3.04638438
71synaptic vesicle endocytosis (GO:0048488)3.04018172
72regulation of NFAT protein import into nucleus (GO:0051532)3.02974216
73negative regulation of neurotransmitter transport (GO:0051589)3.02420858
74regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.00680535
75cerebellar Purkinje cell differentiation (GO:0021702)3.00580598
76negative regulation of neurotransmitter secretion (GO:0046929)3.00097175
77establishment of protein localization to Golgi (GO:0072600)2.99372541
78neuronal action potential propagation (GO:0019227)2.98058029
79positive regulation of mRNA 3-end processing (GO:0031442)2.96763010
80histone H2A acetylation (GO:0043968)2.96090899
81negative regulation of synaptic transmission, GABAergic (GO:0032229)2.95184282
82histone H3-K9 demethylation (GO:0033169)2.94588374
83positive regulation of mitotic sister chromatid separation (GO:1901970)2.94464463
84positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.94464463
85positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.94464463
86cyclic nucleotide catabolic process (GO:0009214)2.92803400
87nucleus localization (GO:0051647)2.91157330
88regulation of postsynaptic membrane potential (GO:0060078)2.90865168
89regulation of synaptic vesicle exocytosis (GO:2000300)2.90565658
90L-amino acid import (GO:0043092)2.90278662
91G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.90148775
92cAMP catabolic process (GO:0006198)2.89426892
93histone lysine demethylation (GO:0070076)2.89314197
94gamma-aminobutyric acid signaling pathway (GO:0007214)2.89104986
95regulation of DNA damage checkpoint (GO:2000001)2.88377740
96non-recombinational repair (GO:0000726)2.88025342
97double-strand break repair via nonhomologous end joining (GO:0006303)2.88025342
98mitotic chromosome condensation (GO:0007076)2.87358650
99histone H3-K9 modification (GO:0061647)2.86528907
100glutamate secretion (GO:0014047)2.86300133
101somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.85825389
102somatic cell DNA recombination (GO:0016444)2.85825389
103histone H3-K9 methylation (GO:0051567)2.83815907
104positive regulation of membrane potential (GO:0045838)2.83685669
105regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.83665628
106positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.83665628
107histone mRNA catabolic process (GO:0071044)2.83214414
108regulation of mRNA 3-end processing (GO:0031440)2.80379793
109negative regulation of dendrite development (GO:2000171)2.80122772
110regulation of histone H3-K27 methylation (GO:0061085)2.76823383
111regulation of glutamate receptor signaling pathway (GO:1900449)2.76399850
112regulation of histone H3-K4 methylation (GO:0051569)2.75035841
113central nervous system projection neuron axonogenesis (GO:0021952)2.74897405
114positive regulation of granulocyte differentiation (GO:0030854)2.74893920
115behavioral response to ethanol (GO:0048149)2.74518749
116positive regulation of histone methylation (GO:0031062)2.74289094
117protein K48-linked deubiquitination (GO:0071108)2.73820439
118protein targeting to Golgi (GO:0000042)2.72703427
119microtubule anchoring (GO:0034453)2.72578857
120positive regulation of mRNA catabolic process (GO:0061014)2.72355867
121regulation of pigment cell differentiation (GO:0050932)2.71548134
122histone H4-K16 acetylation (GO:0043984)2.70008074
123definitive hemopoiesis (GO:0060216)2.69366548
124kinetochore organization (GO:0051383)2.68985826
125protein K11-linked deubiquitination (GO:0035871)2.68920881
126histone methylation (GO:0016571)2.68724466
127positive regulation of mRNA processing (GO:0050685)2.68435561
128regulation of synaptic vesicle transport (GO:1902803)2.67816491
129nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.67740979
130positive regulation of developmental pigmentation (GO:0048087)2.67437408
131positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.67434473
132regulation of histone methylation (GO:0031060)2.67408551
133regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.66851363
134negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.66760624
135nucleus organization (GO:0006997)2.65524731
136regulation of centrosome cycle (GO:0046605)2.65194023
137negative regulation of cell cycle G2/M phase transition (GO:1902750)2.64808524
138negative regulation of DNA repair (GO:0045738)2.64802073
139positive regulation of mRNA metabolic process (GO:1903313)2.64253786
140positive regulation of DNA-templated transcription, initiation (GO:2000144)2.64015314
141regulation of long-term neuronal synaptic plasticity (GO:0048169)2.63622198
142histone demethylation (GO:0016577)2.63392278
143negative regulation of mRNA processing (GO:0050686)2.63045950
144protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.62019478
145gamma-aminobutyric acid transport (GO:0015812)2.61660373
146regulation of dendritic spine development (GO:0060998)2.61383052
147negative regulation of mRNA metabolic process (GO:1903312)2.61166658
148regulation of neurotransmitter secretion (GO:0046928)2.60966279
149DNA conformation change (GO:0071103)2.59493760
150negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.58919750
151central nervous system neuron axonogenesis (GO:0021955)2.58316734
152mRNA transport (GO:0051028)2.57771695
153regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.57741884
154positive regulation of meiosis (GO:0045836)2.57703515
155synapse assembly (GO:0007416)2.56838745
156righting reflex (GO:0060013)2.56718178
157phosphatidylinositol dephosphorylation (GO:0046856)2.55113267
158long-term memory (GO:0007616)2.53617618
159establishment of nucleus localization (GO:0040023)2.53215786
160axonal fasciculation (GO:0007413)2.52503187
161regulation of neuronal synaptic plasticity (GO:0048168)2.51991508
162dendrite morphogenesis (GO:0048813)2.49516554
163neurotransmitter-gated ion channel clustering (GO:0072578)2.49080625
164detection of calcium ion (GO:0005513)2.48144749
165learning (GO:0007612)2.46023185
166phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.45719115
167neuron recognition (GO:0008038)2.40212308
168replicative senescence (GO:0090399)2.38870391
169membrane depolarization (GO:0051899)2.38036563
170calcium ion import (GO:0070509)2.37225284
171regulation of synaptic plasticity (GO:0048167)2.35503675
172regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.35498917
173membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.34457829
174associative learning (GO:0008306)2.33761746
175exploration behavior (GO:0035640)2.33217826
176glycosphingolipid biosynthetic process (GO:0006688)2.32150639
177dendritic spine morphogenesis (GO:0060997)2.31608145
178cranial nerve structural organization (GO:0021604)2.30635781
179regulation of neurotransmitter transport (GO:0051588)2.29661512
180negative regulation of T cell mediated immunity (GO:0002710)2.28367239
181negative regulation of exocytosis (GO:0045920)2.28339370
182visual learning (GO:0008542)2.28189365
183mechanosensory behavior (GO:0007638)2.27777010
184inner ear receptor cell development (GO:0060119)2.26386008
185protein localization to cilium (GO:0061512)2.25644622
186piRNA metabolic process (GO:0034587)2.25637623
187mRNA splice site selection (GO:0006376)2.24396710
188regulation of synaptic transmission, glutamatergic (GO:0051966)2.23610010
189DNA damage induced protein phosphorylation (GO:0006975)2.23524960
190regulation of respiratory gaseous exchange (GO:0043576)2.23249112
191facial nerve structural organization (GO:0021612)2.23126198
192glycerophospholipid catabolic process (GO:0046475)2.22493041
193peptidyl-lysine trimethylation (GO:0018023)2.22201824

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.42982999
2EZH2_22144423_ChIP-Seq_EOC_Human4.62339157
3GBX2_23144817_ChIP-Seq_PC3_Human4.23504933
4KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.07928104
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.75280210
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.47400476
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.44094092
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.41377700
9GATA1_22025678_ChIP-Seq_K562_Human2.37328113
10SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.34161699
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.33056722
12AR_21572438_ChIP-Seq_LNCaP_Human2.29360454
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.21716347
14TAF15_26573619_Chip-Seq_HEK293_Human2.09262260
15* FUS_26573619_Chip-Seq_HEK293_Human2.08789462
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08228418
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01645181
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.98380718
19JARID2_20064375_ChIP-Seq_MESCs_Mouse1.96842986
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.95287301
21IGF1R_20145208_ChIP-Seq_DFB_Human1.95040447
22P300_19829295_ChIP-Seq_ESCs_Human1.92940510
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.90174426
24SMAD4_21799915_ChIP-Seq_A2780_Human1.89018021
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.85968455
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.85137082
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.79149550
28TP53_16413492_ChIP-PET_HCT116_Human1.78530389
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77748054
30TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.77489594
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76965052
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.76636599
33* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75999191
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75315890
35NANOG_18555785_Chip-Seq_ESCs_Mouse1.73978245
36EWS_26573619_Chip-Seq_HEK293_Human1.69120619
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68864674
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.68780910
39DROSHA_22980978_ChIP-Seq_HELA_Human1.66295161
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.66061847
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65259499
42SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.65242356
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.64352928
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61620187
45EZH2_27304074_Chip-Seq_ESCs_Mouse1.60876990
46STAT3_23295773_ChIP-Seq_U87_Human1.59942685
47FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.59060142
48EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.58376662
49* SMAD3_21741376_ChIP-Seq_EPCs_Human1.58039729
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.56991390
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56566907
52* TCF4_23295773_ChIP-Seq_U87_Human1.56525377
53EZH2_18974828_ChIP-Seq_MESCs_Mouse1.56474267
54RNF2_18974828_ChIP-Seq_MESCs_Mouse1.56474267
55E2F1_18555785_Chip-Seq_ESCs_Mouse1.56084034
56HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.54926078
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.53097227
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52933721
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.51511875
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.50398062
61AR_25329375_ChIP-Seq_VCAP_Human1.49276883
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48377868
63P53_22387025_ChIP-Seq_ESCs_Mouse1.47001204
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45830721
65E2F1_21310950_ChIP-Seq_MCF-7_Human1.44954082
66ER_23166858_ChIP-Seq_MCF-7_Human1.44917269
67JARID2_20075857_ChIP-Seq_MESCs_Mouse1.44519706
68CMYC_18555785_Chip-Seq_ESCs_Mouse1.44509592
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.44412368
70REST_21632747_ChIP-Seq_MESCs_Mouse1.43215059
71SUZ12_18555785_Chip-Seq_ESCs_Mouse1.42202221
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40297694
73SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.39223447
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39160459
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.38401990
76TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37678033
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37135132
78PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.36460836
79P300_18555785_Chip-Seq_ESCs_Mouse1.36187543
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.36152779
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35753623
82FLI1_21867929_ChIP-Seq_TH2_Mouse1.35542542
83CBX2_27304074_Chip-Seq_ESCs_Mouse1.35415223
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.33968484
85YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32896769
86PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32593506
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32204617
88STAT3_18555785_Chip-Seq_ESCs_Mouse1.32075635
89EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.31262209
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.31144120
91RNF2_27304074_Chip-Seq_NSC_Mouse1.30700087
92TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.30112869
93FOXM1_26456572_ChIP-Seq_MCF-7_Human1.29348595
94MTF2_20144788_ChIP-Seq_MESCs_Mouse1.29200689
95STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29194149
96NMYC_18555785_Chip-Seq_ESCs_Mouse1.28838431
97* RUNX2_22187159_ChIP-Seq_PCA_Human1.28716914
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28473639
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28473639
100TP63_19390658_ChIP-ChIP_HaCaT_Human1.28228207
101FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.27398751
102SOX2_18555785_Chip-Seq_ESCs_Mouse1.26303176
103TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26000793
104* TP53_18474530_ChIP-ChIP_U2OS_Human1.25786173
105MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25781615
106SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.25040452
107SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24917278
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24649278
109ARNT_22903824_ChIP-Seq_MCF-7_Human1.24082961
110PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24016560
111VDR_22108803_ChIP-Seq_LS180_Human1.23112956
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23035730
113BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21389463
114RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.21213402
115BCAT_22108803_ChIP-Seq_LS180_Human1.20792016
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20641875
117OCT4_18555785_Chip-Seq_ESCs_Mouse1.18939157
118PRDM14_20953172_ChIP-Seq_ESCs_Human1.18673867
119* SOX2_21211035_ChIP-Seq_LN229_Gbm1.18203066
120RUNX1_27457419_Chip-Seq_LIVER_Mouse1.17982051
121FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.17262895
122ELK1_19687146_ChIP-ChIP_HELA_Human1.16663904
123AR_21909140_ChIP-Seq_LNCAP_Human1.16539177
124ZNF274_21170338_ChIP-Seq_K562_Hela1.16157708
125EZH2_27294783_Chip-Seq_ESCs_Mouse1.15444127
126AHR_22903824_ChIP-Seq_MCF-7_Human1.14096687
127KDM2B_26808549_Chip-Seq_REH_Human1.13697909
128PU1_27457419_Chip-Seq_LIVER_Mouse1.12683564
129YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09123348
130TCF4_18268006_ChIP-ChIP_LS174T_Human1.06705682
131TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04453596
132NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.04323210
133TBX3_20139965_ChIP-Seq_MESCs_Mouse1.04267025
134OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03436625
135STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.02814192
136SOX9_26525672_Chip-Seq_HEART_Mouse1.01922268
137CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01529612
138NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99051195
139NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99051195
140WT1_19549856_ChIP-ChIP_CCG9911_Human0.98708421
141SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97164006
142CRX_20693478_ChIP-Seq_RETINA_Mouse0.95630365
143* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94775624
144IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94696606
145CBP_20019798_ChIP-Seq_JUKART_Human0.94696606

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.45654613
2MP0000569_abnormal_digit_pigmentation3.13013350
3MP0003880_abnormal_central_pattern3.11765546
4MP0003635_abnormal_synaptic_transmissio2.88000835
5MP0009745_abnormal_behavioral_response2.85130238
6MP0003787_abnormal_imprinting2.83269806
7MP0001188_hyperpigmentation2.77342259
8MP0010352_gastrointestinal_tract_polyps2.68364008
9MP0002166_altered_tumor_susceptibility2.56333345
10MP0004270_analgesia2.40762935
11MP0009046_muscle_twitch2.40406726
12MP0002063_abnormal_learning/memory/cond2.40267924
13MP0003111_abnormal_nucleus_morphology2.37005533
14MP0005646_abnormal_pituitary_gland2.35050154
15MP0005171_absent_coat_pigmentation2.30975396
16MP0001486_abnormal_startle_reflex2.14646958
17MP0001968_abnormal_touch/_nociception2.11200914
18MP0002572_abnormal_emotion/affect_behav2.10178003
19MP0005503_abnormal_tendon_morphology2.09430845
20MP0002064_seizures2.08664272
21MP0002734_abnormal_mechanical_nocicepti2.07857217
22MP0002735_abnormal_chemical_nociception2.07543072
23MP0002272_abnormal_nervous_system2.06981264
24MP0003077_abnormal_cell_cycle1.99829570
25MP0000778_abnormal_nervous_system1.99451922
26MP0000015_abnormal_ear_pigmentation1.99359305
27MP0008057_abnormal_DNA_replication1.98416771
28MP0001984_abnormal_olfaction1.96239230
29MP0010307_abnormal_tumor_latency1.92302491
30MP0008877_abnormal_DNA_methylation1.88095781
31MP0006292_abnormal_olfactory_placode1.85662648
32MP0008569_lethality_at_weaning1.74477596
33MP0003943_abnormal_hepatobiliary_system1.74295009
34MP0005423_abnormal_somatic_nervous1.70540354
35MP0001501_abnormal_sleep_pattern1.69859214
36MP0000427_abnormal_hair_cycle1.65323192
37MP0001177_atelectasis1.64574245
38MP0003763_abnormal_thymus_physiology1.62387808
39MP0002736_abnormal_nociception_after1.62175039
40MP0002067_abnormal_sensory_capabilities1.60239293
41MP0002006_tumorigenesis1.59453541
42MP0002822_catalepsy1.57246433
43MP0004808_abnormal_hematopoietic_stem1.56953606
44MP0000383_abnormal_hair_follicle1.54586401
45MP0003567_abnormal_fetal_cardiomyocyte1.54076146
46MP0003221_abnormal_cardiomyocyte_apopto1.49587906
47MP0005409_darkened_coat_color1.49366074
48MP0005645_abnormal_hypothalamus_physiol1.49226438
49MP0002084_abnormal_developmental_patter1.48177404
50MP0004742_abnormal_vestibular_system1.47264385
51MP0002876_abnormal_thyroid_physiology1.46726171
52MP0003937_abnormal_limbs/digits/tail_de1.44831356
53MP0004957_abnormal_blastocyst_morpholog1.41934226
54MP0005187_abnormal_penis_morphology1.39790126
55MP0009703_decreased_birth_body1.39337062
56MP0002557_abnormal_social/conspecific_i1.38606619
57MP0002088_abnormal_embryonic_growth/wei1.37617643
58MP0008961_abnormal_basal_metabolism1.37318077
59MP0005499_abnormal_olfactory_system1.37024790
60MP0005394_taste/olfaction_phenotype1.37024790
61MP0002928_abnormal_bile_duct1.36733111
62MP0003984_embryonic_growth_retardation1.35715424
63MP0001672_abnormal_embryogenesis/_devel1.34163794
64MP0005380_embryogenesis_phenotype1.34163794
65MP0001440_abnormal_grooming_behavior1.31699434
66MP0003121_genomic_imprinting1.31398606
67MP0004197_abnormal_fetal_growth/weight/1.30829465
68MP0005386_behavior/neurological_phenoty1.30202875
69MP0004924_abnormal_behavior1.30202875
70MP0000350_abnormal_cell_proliferation1.29817956
71MP0001970_abnormal_pain_threshold1.29318052
72MP0002009_preneoplasia1.27982829
73MP0002396_abnormal_hematopoietic_system1.27169988
74MP0005174_abnormal_tail_pigmentation1.24204199
75MP0009780_abnormal_chondrocyte_physiolo1.23757440
76MP0004147_increased_porphyrin_level1.23549929
77MP0000631_abnormal_neuroendocrine_gland1.22755438
78MP0008007_abnormal_cellular_replicative1.21197426
79MP0001730_embryonic_growth_arrest1.20652606
80MP0001502_abnormal_circadian_rhythm1.19958458
81MP0000428_abnormal_craniofacial_morphol1.18864971
82MP0002184_abnormal_innervation1.18558862
83MP0003879_abnormal_hair_cell1.17226311
84MP0001963_abnormal_hearing_physiology1.16379292
85MP0002638_abnormal_pupillary_reflex1.14830186
86MP0001905_abnormal_dopamine_level1.13306398
87MP0001697_abnormal_embryo_size1.13228013
88MP0005220_abnormal_exocrine_pancreas1.13074009
89MP0003786_premature_aging1.12847609
90MP0010386_abnormal_urinary_bladder1.11286652
91MP0000955_abnormal_spinal_cord1.09960661
92MP0002102_abnormal_ear_morphology1.08902211
93MP0002086_abnormal_extraembryonic_tissu1.07229812
94MP0003300_gastrointestinal_ulcer1.04013356
95MP0002733_abnormal_thermal_nociception1.03899640
96MP0003656_abnormal_erythrocyte_physiolo1.02930477
97MP0002095_abnormal_skin_pigmentation1.01548611
98MP0003935_abnormal_craniofacial_develop1.01466138
99MP0000920_abnormal_myelination1.00467597
100MP0002882_abnormal_neuron_morphology0.96868448
101MP0008058_abnormal_DNA_repair0.95271443
102MP0002075_abnormal_coat/hair_pigmentati0.94734145
103MP0001661_extended_life_span0.93849590
104MP0004134_abnormal_chest_morphology0.92962590
105MP0001286_abnormal_eye_development0.92555098
106MP0010234_abnormal_vibrissa_follicle0.92337715
107MP0004185_abnormal_adipocyte_glucose0.91375089
108MP0005551_abnormal_eye_electrophysiolog0.89965081
109MP0008932_abnormal_embryonic_tissue0.89713283
110MP0006072_abnormal_retinal_apoptosis0.88592726
111MP0004142_abnormal_muscle_tone0.88226561
112MP0005410_abnormal_fertilization0.88193146
113MP0002152_abnormal_brain_morphology0.88071834
114MP0005076_abnormal_cell_differentiation0.87485228
115MP0002085_abnormal_embryonic_tissue0.87267978
116MP0004233_abnormal_muscle_weight0.87106965
117MP0004811_abnormal_neuron_physiology0.86752193
118MP0003693_abnormal_embryo_hatching0.85062428
119MP0002066_abnormal_motor_capabilities/c0.84945972
120MP0000681_abnormal_thyroid_gland0.84681213
121MP0000703_abnormal_thymus_morphology0.84584235
122MP0005248_abnormal_Harderian_gland0.84003010
123MP0001485_abnormal_pinna_reflex0.83197931
124MP0008995_early_reproductive_senescence0.83057566
125MP0008789_abnormal_olfactory_epithelium0.82375116
126MP0000371_diluted_coat_color0.81637930
127MP0002229_neurodegeneration0.81374833
128MP0000462_abnormal_digestive_system0.80336925
129MP0003252_abnormal_bile_duct0.79519274
130MP0002080_prenatal_lethality0.79129863
131MP0006276_abnormal_autonomic_nervous0.77764429
132MP0001873_stomach_inflammation0.76205709
133MP0005621_abnormal_cell_physiology0.74784270
134MP0005075_abnormal_melanosome_morpholog0.74680402
135MP0003698_abnormal_male_reproductive0.74299740
136MP0002114_abnormal_axial_skeleton0.74193144
137MP0009672_abnormal_birth_weight0.74093545
138MP0002177_abnormal_outer_ear0.73889051
139MP0002269_muscular_atrophy0.73353309
140MP0005671_abnormal_response_to0.72759800
141MP0002697_abnormal_eye_size0.72748091
142MP0002090_abnormal_vision0.72381816
143MP0004084_abnormal_cardiac_muscle0.71938878
144MP0003890_abnormal_embryonic-extraembry0.71636975
145MP0002877_abnormal_melanocyte_morpholog0.71375888
146MP0008872_abnormal_physiological_respon0.71279330
147MP0001784_abnormal_fluid_regulation0.71220057
148MP0003631_nervous_system_phenotype0.70893958
149MP0000432_abnormal_head_morphology0.70201513
150MP0003633_abnormal_nervous_system0.69419535
151MP0005253_abnormal_eye_physiology0.69042642
152MP0003861_abnormal_nervous_system0.68971627
153MP0005384_cellular_phenotype0.68667071
154MP0002160_abnormal_reproductive_system0.68616497
155MP0001191_abnormal_skin_condition0.68129642
156MP0002925_abnormal_cardiovascular_devel0.68110068
157MP0001915_intracranial_hemorrhage0.67839106
158MP0002108_abnormal_muscle_morphology0.67452063
159MP0003632_abnormal_nervous_system0.66298758
160MP0003690_abnormal_glial_cell0.66102941
161MP0003122_maternal_imprinting0.65756701
162MP0000026_abnormal_inner_ear0.65521093
163MP0001929_abnormal_gametogenesis0.65250824
164MP0004885_abnormal_endolymph0.64743933
165MP0010678_abnormal_skin_adnexa0.64528973
166MP0002081_perinatal_lethality0.63016521
167MP0010094_abnormal_chromosome_stability0.63009492
168MP0001986_abnormal_taste_sensitivity0.62414692
169MP0003938_abnormal_ear_development0.61944753
170MP0003136_yellow_coat_color0.61025019
171MP0009697_abnormal_copulation0.60701908
172MP0002752_abnormal_somatic_nervous0.60416515
173MP0001186_pigmentation_phenotype0.59494638
174MP0000372_irregular_coat_pigmentation0.59334468

Predicted human phenotypes

RankGene SetZ-score
1Protruding tongue (HP:0010808)4.56106352
2Focal motor seizures (HP:0011153)4.44595423
3Gaze-evoked nystagmus (HP:0000640)4.01311477
4Febrile seizures (HP:0002373)3.86362485
5Neoplasm of the adrenal cortex (HP:0100641)3.43331777
6Scanning speech (HP:0002168)3.37869877
7Epileptic encephalopathy (HP:0200134)3.32966367
8Impaired smooth pursuit (HP:0007772)3.32466186
9Hypoplasia of the thymus (HP:0000778)3.22808093
10Progressive cerebellar ataxia (HP:0002073)3.19826094
11Chronic hepatic failure (HP:0100626)3.15958750
12Severe combined immunodeficiency (HP:0004430)3.12280882
13Abnormality of ocular smooth pursuit (HP:0000617)3.05997826
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.05678921
15Stomach cancer (HP:0012126)3.05040380
16Chromsome breakage (HP:0040012)2.92707071
17Focal seizures (HP:0007359)2.88451807
18Truncal obesity (HP:0001956)2.86010516
19Sandal gap (HP:0001852)2.83355755
20Broad-based gait (HP:0002136)2.78898264
21B lymphocytopenia (HP:0010976)2.78500987
22Absent frontal sinuses (HP:0002688)2.74621922
23Retinal dysplasia (HP:0007973)2.74355790
24T lymphocytopenia (HP:0005403)2.72480555
25Combined immunodeficiency (HP:0005387)2.68937058
26Panhypogammaglobulinemia (HP:0003139)2.64298266
27Acute myeloid leukemia (HP:0004808)2.63917507
28Abnormality of chromosome segregation (HP:0002916)2.63637955
29Overlapping toe (HP:0001845)2.59368325
30Embryonal renal neoplasm (HP:0011794)2.58123393
31Fair hair (HP:0002286)2.54932438
32Mild short stature (HP:0003502)2.52471164
33Acute lymphatic leukemia (HP:0006721)2.52437845
34Absent/shortened dynein arms (HP:0200106)2.52393185
35Dynein arm defect of respiratory motile cilia (HP:0012255)2.52393185
36Generalized hypopigmentation of hair (HP:0011358)2.52261229
37Dysdiadochokinesis (HP:0002075)2.50025894
38Prostate neoplasm (HP:0100787)2.45737241
39Abnormality of the fingertips (HP:0001211)2.45195706
40Abnormal hair whorl (HP:0010721)2.44832258
41Atonic seizures (HP:0010819)2.43418358
42Abnormality of the left ventricular outflow tract (HP:0011103)2.41573545
43Subaortic stenosis (HP:0001682)2.41573545
44Dysmetric saccades (HP:0000641)2.41114733
45Prominent nose (HP:0000448)2.40716230
46Abnormality of B cell number (HP:0010975)2.40096599
47Hyperventilation (HP:0002883)2.39284865
48Deep philtrum (HP:0002002)2.37928004
49Abnormality of midbrain morphology (HP:0002418)2.37453633
50Molar tooth sign on MRI (HP:0002419)2.37453633
51Aplasia/Hypoplasia of the uvula (HP:0010293)2.34860797
52Tubulointerstitial nephritis (HP:0001970)2.31184092
53Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.25305365
54Hypothermia (HP:0002045)2.23288229
55Hypoplastic labia majora (HP:0000059)2.22827816
56Absent speech (HP:0001344)2.19037003
57Genetic anticipation (HP:0003743)2.18942982
58Curly hair (HP:0002212)2.18784809
59Relative macrocephaly (HP:0004482)2.17317066
60Rhabdomyosarcoma (HP:0002859)2.17207900
61Drooling (HP:0002307)2.16099316
62Excessive salivation (HP:0003781)2.16099316
63Pancreatic fibrosis (HP:0100732)2.16006073
64Submucous cleft hard palate (HP:0000176)2.14596569
65Blue irides (HP:0000635)2.14236102
66Abnormality of T cell number (HP:0011839)2.13598913
67Neonatal hypoglycemia (HP:0001998)2.10896303
68Urinary bladder sphincter dysfunction (HP:0002839)2.08533061
69Heterotopia (HP:0002282)2.08094954
70Papillary thyroid carcinoma (HP:0002895)2.07188572
71Widely spaced teeth (HP:0000687)2.06732178
72Abnormality of the frontal sinuses (HP:0002687)2.05567738
73Medulloblastoma (HP:0002885)2.05475622
74Abnormality of the renal collecting system (HP:0004742)2.02383140
75Degeneration of the lateral corticospinal tracts (HP:0002314)2.02366161
76Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.02366161
77Cortical dysplasia (HP:0002539)2.01735738
78Hepatoblastoma (HP:0002884)2.01073211
79Clubbing of toes (HP:0100760)2.00358489
80Cystic hygroma (HP:0000476)1.99681122
81Thyroiditis (HP:0100646)1.98390027
82Obsessive-compulsive behavior (HP:0000722)1.96936129
83Abnormality of the labia majora (HP:0012881)1.96100219
84Postaxial foot polydactyly (HP:0001830)1.96077893
85Intestinal atresia (HP:0011100)1.95779275
86Termporal pattern (HP:0011008)1.95373951
87Insidious onset (HP:0003587)1.95373951
88Abnormality of the corticospinal tract (HP:0002492)1.95092580
89Renal cortical cysts (HP:0000803)1.94682903
90Short 4th metacarpal (HP:0010044)1.91900505
91Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.91900505
92Low anterior hairline (HP:0000294)1.91260656
93Fetal akinesia sequence (HP:0001989)1.91070673
94Abnormality of saccadic eye movements (HP:0000570)1.90389063
95Abnormality of the incisor (HP:0000676)1.90028504
96Conical tooth (HP:0000698)1.89898133
97Inappropriate behavior (HP:0000719)1.89029724
98Abnormal ciliary motility (HP:0012262)1.88343219
99Facial cleft (HP:0002006)1.87834042
100Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.86783729
101Diastasis recti (HP:0001540)1.85130646
102Abnormality of the astrocytes (HP:0100707)1.84582966
103Astrocytoma (HP:0009592)1.84582966
104Sloping forehead (HP:0000340)1.84068558
105Intellectual disability, moderate (HP:0002342)1.83068368
106Cafe-au-lait spot (HP:0000957)1.82922549
107Abnormal biliary tract morphology (HP:0012440)1.82614694
108Myelodysplasia (HP:0002863)1.81990483
109Abnormal number of incisors (HP:0011064)1.81776721
110Small hand (HP:0200055)1.79831820
111Dialeptic seizures (HP:0011146)1.79695442
112Missing ribs (HP:0000921)1.78541086
113Duplicated collecting system (HP:0000081)1.77621141
114Abnormality of the renal cortex (HP:0011035)1.76390856
115Neoplasm of striated muscle (HP:0009728)1.76116327
116Fibular hypoplasia (HP:0003038)1.75523059
11711 pairs of ribs (HP:0000878)1.74790871
118Cutis marmorata (HP:0000965)1.74680787
119Dysmetria (HP:0001310)1.74585284
120Long foot (HP:0001833)1.73265599
121Poor coordination (HP:0002370)1.72780977
122Papilledema (HP:0001085)1.72745816
123Impaired vibratory sensation (HP:0002495)1.72157418
124Absence seizures (HP:0002121)1.71200602
125Hip dysplasia (HP:0001385)1.69692379
126Abnormality of DNA repair (HP:0003254)1.69344689
127Poor eye contact (HP:0000817)1.69195946
128Optic nerve hypoplasia (HP:0000609)1.69140690
129Pancreatic islet-cell hyperplasia (HP:0004510)1.68894207
130Impaired vibration sensation in the lower limbs (HP:0002166)1.68694466
131Cubitus valgus (HP:0002967)1.68528608
132Thyroid carcinoma (HP:0002890)1.68474368
133True hermaphroditism (HP:0010459)1.68200452
134Narrow palate (HP:0000189)1.67490015
135Macroorchidism (HP:0000053)1.67245816
136Abnormal respiratory motile cilium physiology (HP:0012261)1.66957403
137Abnormality of salivation (HP:0100755)1.66811525
138Abnormality of the preputium (HP:0100587)1.66561923
139Macroglossia (HP:0000158)1.65983078
140Flat occiput (HP:0005469)1.65964559
141Short middle phalanx of the 5th finger (HP:0004220)1.65432869
142Abnormality of incisor morphology (HP:0011063)1.64575255
143Ectopic kidney (HP:0000086)1.64277191
144Elfin facies (HP:0004428)1.64224098
145Glioma (HP:0009733)1.64107395
146Increased nuchal translucency (HP:0010880)1.64065926
147Decreased lacrimation (HP:0000633)1.63822475
148Abnormality of the ileum (HP:0001549)1.63793754
149Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.62987639
150Gait imbalance (HP:0002141)1.62718406
151Hypoplastic iliac wings (HP:0002866)1.62655836
152Thick eyebrow (HP:0000574)1.62593862
153Nephroblastoma (Wilms tumor) (HP:0002667)1.62485630
154Congenital hepatic fibrosis (HP:0002612)1.62457666
155Subacute progressive viral hepatitis (HP:0006572)1.62430713
156Neonatal short-limb short stature (HP:0008921)1.62408735
157Broad alveolar ridges (HP:0000187)1.61817888
158Hypopigmentation of the fundus (HP:0007894)1.60936424
159Bladder carcinoma (HP:0002862)1.60084553
160Bladder neoplasm (HP:0009725)1.60084553
161Aqueductal stenosis (HP:0002410)1.59891198
162Colon cancer (HP:0003003)1.59545204
163Generalized tonic-clonic seizures (HP:0002069)1.59324038
164Neoplasm of the small intestine (HP:0100833)1.59028584
165Meckel diverticulum (HP:0002245)1.58781642
166Neoplasm of the tracheobronchial system (HP:0100552)1.58446278
167Synophrys (HP:0000664)1.57978657
168Long clavicles (HP:0000890)1.57976090
169Abnormality of the prostate (HP:0008775)1.57803741
170Median cleft lip (HP:0000161)1.57282343
171Pheochromocytoma (HP:0002666)1.55552490
172Epiphyseal dysplasia (HP:0002656)1.55529360
173Small intestinal stenosis (HP:0012848)1.54569216
174Enlarged penis (HP:0000040)1.53754793
175Abnormality of chromosome stability (HP:0003220)1.53625793
176Transitional cell carcinoma of the bladder (HP:0006740)1.53321164
177Postural instability (HP:0002172)1.53273390
178Hyperthyroidism (HP:0000836)1.52869068
179Thick nail (HP:0001805)1.52850589
180Volvulus (HP:0002580)1.52773257
181Nephronophthisis (HP:0000090)1.52713857

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.70896574
2INSRR4.04071543
3MAP2K73.52248958
4NTRK33.25713665
5CASK2.84189306
6ZAK2.83447537
7FRK2.74557065
8EPHA42.67969329
9MAP3K42.49908854
10BRSK22.36214556
11PRPF4B2.34139455
12MAP3K102.27847941
13LATS11.80188381
14PNCK1.79792158
15MARK11.72051693
16STK38L1.65225763
17FES1.57944832
18CAMK1D1.57427366
19ACVR1B1.56941723
20SGK21.55324058
21FGFR21.48930692
22EEF2K1.42865652
23CAMKK21.42853033
24BMPR21.42113226
25MAPK131.41961118
26MAP3K141.41368753
27MKNK21.41209372
28TAF11.39085609
29TNK21.35437674
30SCYL21.35211235
31RIPK41.33734897
32RPS6KA41.27859541
33CLK11.25997779
34PLK21.18407989
35YES11.15114542
36BRD41.14888875
37CDK61.12793105
38CDK121.11414940
39CDK31.09008177
40STK241.06630409
41AKT31.04643176
42MAP3K21.04308989
43WEE11.03426501
44TRPM71.01254080
45MAP2K41.00775569
46ERBB31.00054434
47PLK30.99433355
48MAP3K130.98590560
49NTRK20.98238983
50CDC70.96285301
51MAP3K70.96199179
52MKNK10.94105860
53SGK4940.94075578
54SGK2230.94075578
55STK30.93500695
56EIF2AK20.89606060
57NEK60.89520023
58SGK30.87023399
59CDK40.84835429
60MELK0.84348986
61TGFBR10.81719798
62TXK0.80884970
63TAOK20.80466480
64PIK3CA0.79522219
65WNK10.78183890
66PINK10.77737577
67SGK10.77305017
68FGFR10.76707145
69CCNB10.75965987
70PIK3CG0.75172687
71CHEK10.73954735
72CAMK1G0.73880174
73BRSK10.72429744
74PAK30.71938197
75MINK10.71532097
76ICK0.71160923
77TTK0.68416826
78CDK50.67967785
79CAMK10.67214220
80PKN10.65859740
81STK390.65557952
82CSNK1G20.65270862
83VRK10.65035179
84FGFR30.64213789
85TEC0.62776441
86RPS6KB20.62141560
87ATR0.60915793
88CSNK1D0.60861095
89BCR0.60811307
90CAMK2A0.60445557
91CAMK40.59440904
92CSNK1G10.59413425
93CAMK2B0.58738481
94ADRBK20.58012318
95NEK90.57853992
96NLK0.57778859
97MAP3K60.57374001
98RPS6KB10.56911813
99MAP3K50.54334373
100PRKCG0.53126735
101ATM0.53038536
102STK110.52765780
103CHEK20.52765648
104DYRK1A0.52636443
105GRK70.52312645
106BMPR1B0.51655009
107PRKAA20.51458611
108SRPK10.51129271
109PLK10.51089065
110PLK40.50951331
111PRKCQ0.50251257
112TSSK60.49133611
113IRAK40.49097042
114PRKAA10.48447368
115PRKCH0.47948031
116OBSCN0.47748003
117CDK20.47480335
118CDK10.46279596
119CAMKK10.46222121
120PDGFRB0.45607463
121MET0.44962982
122RET0.44693495
123KSR10.44507010
124CSNK1E0.43542848
125PRKG10.43213203
126MARK20.43173626
127PASK0.42742531
128SIK20.42540330
129PAK60.40937086
130DMPK0.40793635
131CSNK1A1L0.40765175
132MAPK70.40032442
133PRKCE0.39087317
134NUAK10.38603972
135FER0.37481489
136MARK30.37440489
137LYN0.36912869
138FGR0.36873292
139PRKDC0.36763647
140DAPK20.36611126
141CAMK2D0.36471121
142HIPK20.35979720
143RAF10.35845314
144GSK3B0.34424796
145MAPK100.33623287
146MAP3K90.30518628
147MAPK140.29795709
148EIF2AK30.29198076
149OXSR10.28473484

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.29408360
2Morphine addiction_Homo sapiens_hsa050322.22550433
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.22244622
4Circadian entrainment_Homo sapiens_hsa047132.20898487
5Glutamatergic synapse_Homo sapiens_hsa047242.19546263
6Cell cycle_Homo sapiens_hsa041102.13376078
7mRNA surveillance pathway_Homo sapiens_hsa030151.98314482
8Amphetamine addiction_Homo sapiens_hsa050311.96870731
9Olfactory transduction_Homo sapiens_hsa047401.93558853
10Taste transduction_Homo sapiens_hsa047421.92320071
11Lysine degradation_Homo sapiens_hsa003101.92209755
12Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.89758687
13Non-homologous end-joining_Homo sapiens_hsa034501.82903132
14Long-term potentiation_Homo sapiens_hsa047201.81714176
15Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.74285749
16RNA transport_Homo sapiens_hsa030131.73901270
17GABAergic synapse_Homo sapiens_hsa047271.70610636
18Serotonergic synapse_Homo sapiens_hsa047261.60486054
19mTOR signaling pathway_Homo sapiens_hsa041501.59718622
20Phosphatidylinositol signaling system_Homo sapiens_hsa040701.53873246
21Long-term depression_Homo sapiens_hsa047301.53687976
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.50667915
23Cholinergic synapse_Homo sapiens_hsa047251.47826086
24Dopaminergic synapse_Homo sapiens_hsa047281.44180002
25Adherens junction_Homo sapiens_hsa045201.43185857
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40683568
27MicroRNAs in cancer_Homo sapiens_hsa052061.40163082
28Selenocompound metabolism_Homo sapiens_hsa004501.38797537
29Thyroid cancer_Homo sapiens_hsa052161.35219130
30Type II diabetes mellitus_Homo sapiens_hsa049301.35035773
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33438879
32Chronic myeloid leukemia_Homo sapiens_hsa052201.33206352
33Cocaine addiction_Homo sapiens_hsa050301.29072553
34Synaptic vesicle cycle_Homo sapiens_hsa047211.28498804
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.27291657
36Insulin secretion_Homo sapiens_hsa049111.26249059
37Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.23906248
38Calcium signaling pathway_Homo sapiens_hsa040201.20600016
39Salivary secretion_Homo sapiens_hsa049701.20102715
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.19527586
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.19129383
42cAMP signaling pathway_Homo sapiens_hsa040241.18511023
43RNA degradation_Homo sapiens_hsa030181.18327703
44Choline metabolism in cancer_Homo sapiens_hsa052311.15957725
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15930362
46Prolactin signaling pathway_Homo sapiens_hsa049171.15589817
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14527670
48Oocyte meiosis_Homo sapiens_hsa041141.14476630
49Oxytocin signaling pathway_Homo sapiens_hsa049211.12587832
50DNA replication_Homo sapiens_hsa030301.09257970
51Renin secretion_Homo sapiens_hsa049241.08974815
52Small cell lung cancer_Homo sapiens_hsa052221.08548442
53Dorso-ventral axis formation_Homo sapiens_hsa043201.07772228
54Nucleotide excision repair_Homo sapiens_hsa034201.07729110
55Alcoholism_Homo sapiens_hsa050341.07012475
56Aldosterone synthesis and secretion_Homo sapiens_hsa049251.06672136
57Spliceosome_Homo sapiens_hsa030401.06121022
58Axon guidance_Homo sapiens_hsa043601.05528174
59Fatty acid biosynthesis_Homo sapiens_hsa000611.05473675
60Renal cell carcinoma_Homo sapiens_hsa052111.01852371
61ErbB signaling pathway_Homo sapiens_hsa040121.00780257
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.00080530
63Inositol phosphate metabolism_Homo sapiens_hsa005620.99672096
64GnRH signaling pathway_Homo sapiens_hsa049120.99137576
65Fanconi anemia pathway_Homo sapiens_hsa034600.96749160
66Gastric acid secretion_Homo sapiens_hsa049710.94262131
67Glioma_Homo sapiens_hsa052140.92838236
68MAPK signaling pathway_Homo sapiens_hsa040100.89627238
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89475303
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88768921
71Mismatch repair_Homo sapiens_hsa034300.87653547
72TGF-beta signaling pathway_Homo sapiens_hsa043500.86963517
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86386356
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85277704
75B cell receptor signaling pathway_Homo sapiens_hsa046620.82647065
76Viral carcinogenesis_Homo sapiens_hsa052030.82320112
77Endometrial cancer_Homo sapiens_hsa052130.82212105
78Hedgehog signaling pathway_Homo sapiens_hsa043400.81472941
79p53 signaling pathway_Homo sapiens_hsa041150.80235897
80Chemokine signaling pathway_Homo sapiens_hsa040620.79122360
81Estrogen signaling pathway_Homo sapiens_hsa049150.78793069
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.78654525
83Prostate cancer_Homo sapiens_hsa052150.78163177
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77991135
85Phototransduction_Homo sapiens_hsa047440.77340103
86Ovarian steroidogenesis_Homo sapiens_hsa049130.77198358
87Platelet activation_Homo sapiens_hsa046110.76668201
88Sphingolipid metabolism_Homo sapiens_hsa006000.75484308
89Ras signaling pathway_Homo sapiens_hsa040140.74550213
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73726416
91Glucagon signaling pathway_Homo sapiens_hsa049220.73332182
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71072748
93T cell receptor signaling pathway_Homo sapiens_hsa046600.70311227
94Acute myeloid leukemia_Homo sapiens_hsa052210.69370975
95Insulin signaling pathway_Homo sapiens_hsa049100.69288283
96Colorectal cancer_Homo sapiens_hsa052100.68773756
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68320791
98Homologous recombination_Homo sapiens_hsa034400.67483973
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67410085
100Systemic lupus erythematosus_Homo sapiens_hsa053220.66735271
101Intestinal immune network for IgA production_Homo sapiens_hsa046720.66218118
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66059675
103Hepatitis B_Homo sapiens_hsa051610.66045224
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65614643
105Insulin resistance_Homo sapiens_hsa049310.64996605
106Measles_Homo sapiens_hsa051620.64902309
107Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64129006
108Autoimmune thyroid disease_Homo sapiens_hsa053200.64004070
109NF-kappa B signaling pathway_Homo sapiens_hsa040640.63917379
110Thyroid hormone synthesis_Homo sapiens_hsa049180.62226509
111Osteoclast differentiation_Homo sapiens_hsa043800.61652114
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61573078
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60326622
114TNF signaling pathway_Homo sapiens_hsa046680.59919105
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59902874
116Herpes simplex infection_Homo sapiens_hsa051680.59815770
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.58834119
118AMPK signaling pathway_Homo sapiens_hsa041520.57216341
119Rap1 signaling pathway_Homo sapiens_hsa040150.56959070
120FoxO signaling pathway_Homo sapiens_hsa040680.56513499
121Circadian rhythm_Homo sapiens_hsa047100.56047809
122Hematopoietic cell lineage_Homo sapiens_hsa046400.55656530
123Ether lipid metabolism_Homo sapiens_hsa005650.55228737
124Basal transcription factors_Homo sapiens_hsa030220.55050099
125Jak-STAT signaling pathway_Homo sapiens_hsa046300.54481703
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54202347
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53758343
128Non-small cell lung cancer_Homo sapiens_hsa052230.53611988
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53598506
130Primary immunodeficiency_Homo sapiens_hsa053400.53400868
131Melanogenesis_Homo sapiens_hsa049160.53398613
132Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53282916
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.52546266
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.52381036
135Maturity onset diabetes of the young_Homo sapiens_hsa049500.51643819
136Pancreatic cancer_Homo sapiens_hsa052120.51624270
137Gap junction_Homo sapiens_hsa045400.51204878
138Pathways in cancer_Homo sapiens_hsa052000.51182824
139African trypanosomiasis_Homo sapiens_hsa051430.50723683
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50572618
141Adipocytokine signaling pathway_Homo sapiens_hsa049200.50498431
142Propanoate metabolism_Homo sapiens_hsa006400.50137880
143Wnt signaling pathway_Homo sapiens_hsa043100.50124474
144RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49652080
145Melanoma_Homo sapiens_hsa052180.49302177
146Type I diabetes mellitus_Homo sapiens_hsa049400.48913335
147Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48691091
148Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48447723
149ABC transporters_Homo sapiens_hsa020100.47129426
150One carbon pool by folate_Homo sapiens_hsa006700.46707465
151Proteoglycans in cancer_Homo sapiens_hsa052050.46314179
152Glycerophospholipid metabolism_Homo sapiens_hsa005640.45252995
153Hippo signaling pathway_Homo sapiens_hsa043900.43640185
154Regulation of autophagy_Homo sapiens_hsa041400.43270561
155HTLV-I infection_Homo sapiens_hsa051660.42663261
156VEGF signaling pathway_Homo sapiens_hsa043700.38406028
157Butanoate metabolism_Homo sapiens_hsa006500.33632619
158Basal cell carcinoma_Homo sapiens_hsa052170.32931031

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