YTHDF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.70087702
2telomere maintenance via semi-conservative replication (GO:0032201)4.19497951
3ribosomal small subunit assembly (GO:0000028)4.17314967
4establishment of integrated proviral latency (GO:0075713)4.11105702
5synapsis (GO:0007129)4.06081189
6DNA strand elongation involved in DNA replication (GO:0006271)4.02020451
7telomere maintenance via recombination (GO:0000722)3.89087754
8DNA replication checkpoint (GO:0000076)3.88462186
9mitotic metaphase plate congression (GO:0007080)3.85968556
10DNA strand elongation (GO:0022616)3.85070619
11DNA replication initiation (GO:0006270)3.77299186
12viral mRNA export from host cell nucleus (GO:0046784)3.75204679
13mitotic recombination (GO:0006312)3.60975784
14DNA damage response, detection of DNA damage (GO:0042769)3.60343292
15ribosome biogenesis (GO:0042254)3.59269481
16purine nucleobase biosynthetic process (GO:0009113)3.57239634
17piRNA metabolic process (GO:0034587)3.52868364
18negative regulation of mitotic sister chromatid separation (GO:2000816)3.52624308
19negative regulation of sister chromatid segregation (GO:0033046)3.52624308
20negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.52624308
21negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.52624308
22negative regulation of mitotic sister chromatid segregation (GO:0033048)3.52624308
23CENP-A containing nucleosome assembly (GO:0034080)3.51309024
24negative regulation of chromosome segregation (GO:0051985)3.50803476
25nucleobase biosynthetic process (GO:0046112)3.47338744
26mitotic sister chromatid cohesion (GO:0007064)3.45188982
27mitotic spindle checkpoint (GO:0071174)3.45162833
28histone H2A acetylation (GO:0043968)3.42700653
29maturation of 5.8S rRNA (GO:0000460)3.41339691
30maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.41083765
31chromatin remodeling at centromere (GO:0031055)3.40062125
32kinetochore organization (GO:0051383)3.37784643
33telomere maintenance via telomere lengthening (GO:0010833)3.35530053
34mitotic sister chromatid segregation (GO:0000070)3.33687506
35regulation of double-strand break repair via homologous recombination (GO:0010569)3.33482730
36mitotic spindle assembly checkpoint (GO:0007094)3.33481420
37non-recombinational repair (GO:0000726)3.31924053
38double-strand break repair via nonhomologous end joining (GO:0006303)3.31924053
39proteasome assembly (GO:0043248)3.31268034
40regulation of helicase activity (GO:0051095)3.30395692
41DNA replication-dependent nucleosome assembly (GO:0006335)3.29382406
42DNA replication-dependent nucleosome organization (GO:0034723)3.29382406
43spindle assembly checkpoint (GO:0071173)3.29239914
44kinetochore assembly (GO:0051382)3.28673744
45chaperone-mediated protein transport (GO:0072321)3.28270455
46maturation of SSU-rRNA (GO:0030490)3.26601580
47nucleotide-excision repair, DNA gap filling (GO:0006297)3.26164395
48DNA ligation (GO:0006266)3.25907696
49metaphase plate congression (GO:0051310)3.24631660
50meiotic chromosome segregation (GO:0045132)3.24043044
51regulation of DNA endoreduplication (GO:0032875)3.23582994
52establishment of viral latency (GO:0019043)3.22244078
53formation of translation preinitiation complex (GO:0001731)3.19950140
54replication fork processing (GO:0031297)3.19763604
55regulation of mitotic metaphase/anaphase transition (GO:0030071)3.18272558
56regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.18272558
57transcription-coupled nucleotide-excision repair (GO:0006283)3.18147136
58regulation of mitotic spindle checkpoint (GO:1903504)3.15792440
59regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.15792440
60establishment of protein localization to mitochondrial membrane (GO:0090151)3.15697153
61ribonucleoprotein complex biogenesis (GO:0022613)3.13970736
62sister chromatid segregation (GO:0000819)3.11856808
63regulation of mitotic sister chromatid separation (GO:0010965)3.11563373
64regulation of mitotic sister chromatid segregation (GO:0033047)3.11563373
65regulation of sister chromatid segregation (GO:0033045)3.11563373
66IMP biosynthetic process (GO:0006188)3.10862001
67negative regulation of DNA-dependent DNA replication (GO:2000104)3.10513657
68protein localization to kinetochore (GO:0034501)3.10492872
69nuclear pore organization (GO:0006999)3.10135927
70regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.09838730
71resolution of meiotic recombination intermediates (GO:0000712)3.09691201
72DNA replication-independent nucleosome organization (GO:0034724)3.09433468
73DNA replication-independent nucleosome assembly (GO:0006336)3.09433468
74spliceosomal snRNP assembly (GO:0000387)3.09058801
75negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.07271566
76negative regulation of ligase activity (GO:0051352)3.07271566
77regulation of chromosome segregation (GO:0051983)3.07010844
78regulation of nuclear cell cycle DNA replication (GO:0033262)3.06932951
79establishment of chromosome localization (GO:0051303)3.06782502
80DNA double-strand break processing (GO:0000729)3.06624025
81transcription elongation from RNA polymerase III promoter (GO:0006385)3.03361088
82termination of RNA polymerase III transcription (GO:0006386)3.03361088
83nuclear pore complex assembly (GO:0051292)3.02460419
84male meiosis I (GO:0007141)3.02277907
85pseudouridine synthesis (GO:0001522)2.99334884
867-methylguanosine mRNA capping (GO:0006370)2.97473476
87transcription from RNA polymerase I promoter (GO:0006360)2.97405979
88ATP-dependent chromatin remodeling (GO:0043044)2.96230258
897-methylguanosine RNA capping (GO:0009452)2.96191625
90RNA capping (GO:0036260)2.96191625
91termination of RNA polymerase I transcription (GO:0006363)2.95877128
92sister chromatid cohesion (GO:0007062)2.95795913
93rRNA processing (GO:0006364)2.92809795
94L-serine metabolic process (GO:0006563)2.90114890
95negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.90079098
96chromosome organization involved in meiosis (GO:0070192)2.90036463
97DNA synthesis involved in DNA repair (GO:0000731)2.89196057
98mitotic nuclear envelope disassembly (GO:0007077)2.88828823
99tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.88535467
100RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.88535467
101deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.88348021
102negative regulation of mRNA processing (GO:0050686)2.87149098
103somatic diversification of immune receptors via somatic mutation (GO:0002566)2.87046643
104somatic hypermutation of immunoglobulin genes (GO:0016446)2.87046643
105cullin deneddylation (GO:0010388)2.86888055
106tRNA aminoacylation for protein translation (GO:0006418)2.86019810
107protein deneddylation (GO:0000338)2.85817221
108exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.85735850
109transcription elongation from RNA polymerase I promoter (GO:0006362)2.84505551
110tRNA aminoacylation (GO:0043039)2.83433302
111amino acid activation (GO:0043038)2.83433302
112rRNA metabolic process (GO:0016072)2.81977102
113regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.81238631
114ribosomal large subunit biogenesis (GO:0042273)2.80846215
115rRNA modification (GO:0000154)2.80795595
116nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.80549868
117negative regulation of mitosis (GO:0045839)2.80372644
118histone exchange (GO:0043486)2.80005473
119DNA-templated transcription, termination (GO:0006353)2.79784699
120negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.79308428
121telomere maintenance (GO:0000723)2.77765682
122protein K6-linked ubiquitination (GO:0085020)2.76963935
123telomere organization (GO:0032200)2.75642227
124anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.75517693
125transcription initiation from RNA polymerase I promoter (GO:0006361)2.75386861
126cell cycle G1/S phase transition (GO:0044843)2.75215545
127G1/S transition of mitotic cell cycle (GO:0000082)2.75215545
128termination of RNA polymerase II transcription (GO:0006369)2.73558658
129attachment of spindle microtubules to kinetochore (GO:0008608)2.73365811
130positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.73203434
131mismatch repair (GO:0006298)2.72532190
132DNA catabolic process, exonucleolytic (GO:0000738)2.72157726
133protein localization to chromosome, centromeric region (GO:0071459)2.70347116
134DNA unwinding involved in DNA replication (GO:0006268)2.68086975
135pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.67955307
136poly(A)+ mRNA export from nucleus (GO:0016973)2.67490503
137ribosome assembly (GO:0042255)2.61868454
138IMP metabolic process (GO:0046040)2.61433115
139regulation of transcription from RNA polymerase I promoter (GO:0006356)2.60320475
140DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.59379771
141histone mRNA metabolic process (GO:0008334)2.59302571
142mRNA export from nucleus (GO:0006406)2.59083277
143membrane disassembly (GO:0030397)2.58501332
144nuclear envelope disassembly (GO:0051081)2.58501332
145DNA-dependent DNA replication (GO:0006261)2.57971461
146signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.57470310
147signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.57470310
148signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.57470310
149transcription elongation from RNA polymerase II promoter (GO:0006368)2.57396372
150spindle checkpoint (GO:0031577)2.57209330
151DNA replication (GO:0006260)2.56660870
152intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.56202494
153signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.56202494

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.40193546
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.94468481
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.42199468
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.35186207
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.16840864
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.04770938
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.02384383
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.94607324
9* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.90253053
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.84643050
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70824704
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.65585021
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.62117057
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.60795347
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.57056394
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.52676686
17* VDR_23849224_ChIP-Seq_CD4+_Human2.45707625
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.37367672
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32506001
20* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24876272
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.18070696
22ELK1_19687146_ChIP-ChIP_HELA_Human2.09186620
23XRN2_22483619_ChIP-Seq_HELA_Human2.08192805
24* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06966097
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.04175865
26FOXP3_21729870_ChIP-Seq_TREG_Human2.03946139
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03509016
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.02526489
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.01707219
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99290507
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.98551480
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.97793777
33DCP1A_22483619_ChIP-Seq_HELA_Human1.93265031
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.91469231
35* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.89495486
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.87968625
37GABP_19822575_ChIP-Seq_HepG2_Human1.83125475
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.80818907
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.78391509
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.76113617
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.75484253
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.75208488
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74649370
44* TTF2_22483619_ChIP-Seq_HELA_Human1.72344971
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.70546292
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67701136
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67332250
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.65261130
49AR_21909140_ChIP-Seq_LNCAP_Human1.65135379
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.64058055
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.62879818
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.60282542
53EGR1_19374776_ChIP-ChIP_THP-1_Human1.60160044
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.56009936
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55798438
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54652033
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.53264611
58HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.50478745
59ZNF274_21170338_ChIP-Seq_K562_Hela1.49718745
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.49386581
61IRF8_22096565_ChIP-ChIP_GC-B_Human1.43345771
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42633748
63SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.41641026
64NANOG_16153702_ChIP-ChIP_HESCs_Human1.41617832
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39920081
66SOX2_16153702_ChIP-ChIP_HESCs_Human1.39432663
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37169391
68CIITA_25753668_ChIP-Seq_RAJI_Human1.36397778
69ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35631848
70IRF8_21731497_ChIP-ChIP_J774_Mouse1.33843575
71EWS_26573619_Chip-Seq_HEK293_Human1.33820168
72SPI1_23547873_ChIP-Seq_NB4_Human1.31211716
73FUS_26573619_Chip-Seq_HEK293_Human1.28668665
74PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.27948081
75IGF1R_20145208_ChIP-Seq_DFB_Human1.24270804
76* KDM5A_27292631_Chip-Seq_BREAST_Human1.21064383
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20998094
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20104172
79IRF1_19129219_ChIP-ChIP_H3396_Human1.17706737
80ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16091892
81GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13516240
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13198630
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12417409
84NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.11363814
85MYC_18940864_ChIP-ChIP_HL60_Human1.09262998
86SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08327860
87MYC_22102868_ChIP-Seq_BL_Human1.07257600
88TFEB_21752829_ChIP-Seq_HELA_Human1.05906133
89SALL1_21062744_ChIP-ChIP_HESCs_Human1.03180570
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00778988
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00707578
92* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99534733
93CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97778498
94SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97692626
95MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.97650473
96PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95900767
97ELK1_22589737_ChIP-Seq_MCF10A_Human0.95179441
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94703388
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94050847
100KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93955357
101CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93824663
102SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.93458456
103* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92960826
104SOX17_20123909_ChIP-Seq_XEN_Mouse0.92153445
105STAT4_19710469_ChIP-ChIP_TH1__Mouse0.90876870
106STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90067674
107POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.83818620
108NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.82484825
109* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.79995742
110KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.79000834
111KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.79000834
112KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.79000834
113DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.78536271
114* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.76213001
115NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.75406737
116MYB_21317192_ChIP-Seq_ERMYB_Mouse0.73773502
117MYB_26560356_Chip-Seq_TH2_Human0.72072780
118VDR_21846776_ChIP-Seq_THP-1_Human0.72039964
119* MYB_26560356_Chip-Seq_TH1_Human0.71644935
120CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.70508621
121CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.70225603
122TCF3_18692474_ChIP-Seq_MEFs_Mouse0.69569007
123POU3F2_20337985_ChIP-ChIP_501MEL_Human0.69369475

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.27453516
2MP0003693_abnormal_embryo_hatching4.19593178
3MP0010094_abnormal_chromosome_stability3.90598724
4MP0008058_abnormal_DNA_repair3.36817657
5MP0003111_abnormal_nucleus_morphology3.24401195
6MP0003077_abnormal_cell_cycle3.20465760
7MP0008007_abnormal_cellular_replicative3.16557968
8MP0004957_abnormal_blastocyst_morpholog3.08405945
9MP0002396_abnormal_hematopoietic_system2.50020358
10MP0006292_abnormal_olfactory_placode2.35452428
11MP0003786_premature_aging2.24211165
12MP0001835_abnormal_antigen_presentation2.20164918
13MP0008932_abnormal_embryonic_tissue2.04636370
14MP0005499_abnormal_olfactory_system1.96046955
15MP0005394_taste/olfaction_phenotype1.96046955
16MP0000490_abnormal_crypts_of1.84310309
17MP0002102_abnormal_ear_morphology1.82591097
18MP0003763_abnormal_thymus_physiology1.80305945
19MP0001529_abnormal_vocalization1.74032475
20MP0000350_abnormal_cell_proliferation1.69302032
21MP0004808_abnormal_hematopoietic_stem1.66146816
22MP0009333_abnormal_splenocyte_physiolog1.65269152
23MP0001545_abnormal_hematopoietic_system1.61373919
24MP0005397_hematopoietic_system_phenotyp1.61373919
25MP0008877_abnormal_DNA_methylation1.59625078
26MP0003123_paternal_imprinting1.59475869
27MP0002009_preneoplasia1.58978974
28MP0005671_abnormal_response_to1.58024591
29MP0000372_irregular_coat_pigmentation1.56005899
30MP0003718_maternal_effect1.54903703
31MP0010307_abnormal_tumor_latency1.52013233
32MP0002233_abnormal_nose_morphology1.49475814
33MP0003937_abnormal_limbs/digits/tail_de1.48969205
34MP0002398_abnormal_bone_marrow1.44785551
35MP0006072_abnormal_retinal_apoptosis1.40856779
36MP0003136_yellow_coat_color1.40549641
37MP0006035_abnormal_mitochondrial_morpho1.39488483
38MP0002148_abnormal_hypersensitivity_rea1.39391748
39MP0000049_abnormal_middle_ear1.37761175
40MP0003880_abnormal_central_pattern1.37747012
41MP0005075_abnormal_melanosome_morpholog1.37287946
42MP0009785_altered_susceptibility_to1.35342337
43MP0003315_abnormal_perineum_morphology1.33510796
44MP0001730_embryonic_growth_arrest1.31768571
45MP0002132_abnormal_respiratory_system1.31383805
46MP0002019_abnormal_tumor_incidence1.30560754
47MP0009672_abnormal_birth_weight1.28546252
48MP0000689_abnormal_spleen_morphology1.27510683
49MP0000313_abnormal_cell_death1.26788702
50MP0010030_abnormal_orbit_morphology1.25371609
51MP0002277_abnormal_respiratory_mucosa1.25223813
52MP0003119_abnormal_digestive_system1.23696304
53MP0002006_tumorigenesis1.21960685
54MP0000685_abnormal_immune_system1.21857832
55MP0002722_abnormal_immune_system1.19272107
56MP0002452_abnormal_antigen_presenting1.18214083
57MP0001800_abnormal_humoral_immune1.17053519
58MP0001672_abnormal_embryogenesis/_devel1.16926433
59MP0005380_embryogenesis_phenotype1.16926433
60MP0002751_abnormal_autonomic_nervous1.16861364
61MP0000566_synostosis1.16215155
62MP0002166_altered_tumor_susceptibility1.15948975
63MP0001119_abnormal_female_reproductive1.15596592
64MP0002420_abnormal_adaptive_immunity1.15050801
65MP0001819_abnormal_immune_cell1.14979110
66MP0000647_abnormal_sebaceous_gland1.14504565
67MP0001286_abnormal_eye_development1.14265400
68MP0000716_abnormal_immune_system1.13256768
69MP0003567_abnormal_fetal_cardiomyocyte1.13019074
70MP0001697_abnormal_embryo_size1.12953403
71MP0002210_abnormal_sex_determination1.12192448
72MP0000015_abnormal_ear_pigmentation1.11335858
73MP0003941_abnormal_skin_development1.11244969
74MP0010352_gastrointestinal_tract_polyps1.10997366
75MP0003698_abnormal_male_reproductive1.09487177
76MP0000703_abnormal_thymus_morphology1.09462915
77MP0002429_abnormal_blood_cell1.09429351
78MP0002697_abnormal_eye_size1.09111431
79MP0005174_abnormal_tail_pigmentation1.07121532
80MP0002405_respiratory_system_inflammati1.06338952
81MP0003943_abnormal_hepatobiliary_system1.05043349
82MP0002723_abnormal_immune_serum1.03547866
83MP0006036_abnormal_mitochondrial_physio1.03082640
84MP0003787_abnormal_imprinting1.03062160
85MP0005000_abnormal_immune_tolerance1.01910108
86MP0002095_abnormal_skin_pigmentation1.01892391
87MP0003436_decreased_susceptibility_to1.01608144
88MP0004133_heterotaxia1.01524701
89MP0002163_abnormal_gland_morphology1.01467626
90MP0003984_embryonic_growth_retardation1.00795733
91MP0009697_abnormal_copulation1.00659537
92MP0002254_reproductive_system_inflammat1.00175711
93MP0001919_abnormal_reproductive_system1.00013903
94MP0000358_abnormal_cell_content/0.99985317
95MP0001293_anophthalmia0.98530010
96MP0005025_abnormal_response_to0.98482101
97MP0009703_decreased_birth_body0.98314941
98MP0003186_abnormal_redox_activity0.98195257
99MP0000858_altered_metastatic_potential0.98175730
100MP0005389_reproductive_system_phenotype0.97792646
101MP0001188_hyperpigmentation0.97338753
102MP0008995_early_reproductive_senescence0.97315362
103MP0001853_heart_inflammation0.97172581
104MP0002088_abnormal_embryonic_growth/wei0.97131876
105MP0003861_abnormal_nervous_system0.97107505
106MP0002938_white_spotting0.94659537
107MP0005253_abnormal_eye_physiology0.94632224
108MP0003755_abnormal_palate_morphology0.94618322
109MP0004782_abnormal_surfactant_physiolog0.94422808
110MP0003890_abnormal_embryonic-extraembry0.94323967
111MP0003221_abnormal_cardiomyocyte_apopto0.93886703
112MP0002080_prenatal_lethality0.93192676
113MP0003806_abnormal_nucleotide_metabolis0.92979268
114MP0002160_abnormal_reproductive_system0.92864515
115MP0002111_abnormal_tail_morphology0.92188625
116MP0005391_vision/eye_phenotype0.92096792
117MP0001984_abnormal_olfaction0.91724422
118MP0002085_abnormal_embryonic_tissue0.89787865
119MP0002086_abnormal_extraembryonic_tissu0.88406331
120MP0001145_abnormal_male_reproductive0.87885879
121MP0003385_abnormal_body_wall0.86772508
122MP0003121_genomic_imprinting0.84315899
123MP0002419_abnormal_innate_immunity0.83603957
124MP0002092_abnormal_eye_morphology0.83440806
125MP0006276_abnormal_autonomic_nervous0.82198707
126MP0003938_abnormal_ear_development0.81958523
127MP0008789_abnormal_olfactory_epithelium0.81355224
128MP0010155_abnormal_intestine_physiology0.81180148
129MP0009278_abnormal_bone_marrow0.78806119
130MP0000653_abnormal_sex_gland0.78794530
131MP0000631_abnormal_neuroendocrine_gland0.78558462
132MP0005367_renal/urinary_system_phenotyp0.78231185
133MP0000516_abnormal_urinary_system0.78231185
134MP0002234_abnormal_pharynx_morphology0.77766028
135MP0004147_increased_porphyrin_level0.75444720
136MP0000778_abnormal_nervous_system0.75197913
137MP0002084_abnormal_developmental_patter0.75051615
138MP0002161_abnormal_fertility/fecundity0.74816581
139MP0000465_gastrointestinal_hemorrhage0.74597805
140MP0001929_abnormal_gametogenesis0.74560405
141MP0004197_abnormal_fetal_growth/weight/0.73539196
142MP0001186_pigmentation_phenotype0.73415375
143MP0001346_abnormal_lacrimal_gland0.72556089
144MP0001764_abnormal_homeostasis0.71152147
145MP0005501_abnormal_skin_physiology0.71055412
146MP0005076_abnormal_cell_differentiation0.70767770
147MP0001790_abnormal_immune_system0.70431151
148MP0003935_abnormal_craniofacial_develop0.68294433
149MP0002090_abnormal_vision0.67340792
150MP0002796_impaired_skin_barrier0.67002150
151MP0000537_abnormal_urethra_morphology0.66844883
152MP0000579_abnormal_nail_morphology0.64802690

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.49699071
2Abnormality of the labia minora (HP:0012880)4.08377874
3Chromsome breakage (HP:0040012)3.92338974
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.91629243
5Aplastic anemia (HP:0001915)3.47998935
6Degeneration of anterior horn cells (HP:0002398)3.36743140
7Abnormality of the anterior horn cell (HP:0006802)3.36743140
8Breast hypoplasia (HP:0003187)3.30499533
9Patellar aplasia (HP:0006443)3.27697880
10Abnormality of the ileum (HP:0001549)3.17251936
11Meckel diverticulum (HP:0002245)3.13757107
12Abnormality of the preputium (HP:0100587)3.10881537
13Type 2 muscle fiber atrophy (HP:0003554)3.09448149
14Aplasia/Hypoplasia of the patella (HP:0006498)3.09304661
15Shoulder girdle muscle weakness (HP:0003547)3.04761957
16Aplasia/Hypoplasia of the uvula (HP:0010293)3.02419368
17Abnormal number of erythroid precursors (HP:0012131)2.98310303
18Abnormality of chromosome stability (HP:0003220)2.95589037
19Type I transferrin isoform profile (HP:0003642)2.93945158
20Muscle fiber atrophy (HP:0100295)2.89900685
21Abnormality of cells of the erythroid lineage (HP:0012130)2.84020931
22Volvulus (HP:0002580)2.83180742
23Myelodysplasia (HP:0002863)2.81967313
2411 pairs of ribs (HP:0000878)2.79707134
25Reticulocytopenia (HP:0001896)2.75542239
26Hyperglycinemia (HP:0002154)2.65827196
27Oral leukoplakia (HP:0002745)2.65273746
28Ependymoma (HP:0002888)2.62507857
29Thrombocytosis (HP:0001894)2.61215171
30Microvesicular hepatic steatosis (HP:0001414)2.56807579
31Cortical dysplasia (HP:0002539)2.55806621
32Absent thumb (HP:0009777)2.55659230
33Acute necrotizing encephalopathy (HP:0006965)2.55289022
34Clubbing of toes (HP:0100760)2.53282758
35Reduced antithrombin III activity (HP:0001976)2.48624460
36Acute encephalopathy (HP:0006846)2.44828782
37Bone marrow hypocellularity (HP:0005528)2.44192382
38Abnormal mitochondria in muscle tissue (HP:0008316)2.36168017
39Capillary hemangiomas (HP:0005306)2.34664697
40Small intestinal stenosis (HP:0012848)2.34193721
41Duodenal stenosis (HP:0100867)2.34193721
42Premature graying of hair (HP:0002216)2.34042199
43Methylmalonic acidemia (HP:0002912)2.32383135
44Ectopic kidney (HP:0000086)2.29000772
45Increased CSF lactate (HP:0002490)2.27769256
46IgG deficiency (HP:0004315)2.26048103
47Increased IgM level (HP:0003496)2.25819000
48Abnormal lung lobation (HP:0002101)2.25341186
49Atrophy/Degeneration involving motor neurons (HP:0007373)2.23555424
50Optic nerve coloboma (HP:0000588)2.23028388
51Nephroblastoma (Wilms tumor) (HP:0002667)2.22478882
52Gonadotropin excess (HP:0000837)2.21601225
53Aplasia/Hypoplasia of the sacrum (HP:0008517)2.20667498
54Selective tooth agenesis (HP:0001592)2.20444486
55Rough bone trabeculation (HP:0100670)2.19849608
56Multiple enchondromatosis (HP:0005701)2.15322545
57Impulsivity (HP:0100710)2.14082290
58Carpal bone hypoplasia (HP:0001498)2.13655190
59Colon cancer (HP:0003003)2.13530260
60Lymphoma (HP:0002665)2.13366204
61Rhabdomyosarcoma (HP:0002859)2.10090163
62IgM deficiency (HP:0002850)2.09582473
63Supernumerary spleens (HP:0009799)2.09146979
64Abnormality of serum amino acid levels (HP:0003112)2.06985388
65Embryonal renal neoplasm (HP:0011794)2.06943327
66Increased hepatocellular lipid droplets (HP:0006565)2.06757834
67Abnormality of male internal genitalia (HP:0000022)2.03766816
68Mitochondrial inheritance (HP:0001427)2.03688082
69Abnormality of serine family amino acid metabolism (HP:0010894)2.03062621
70Abnormality of glycine metabolism (HP:0010895)2.03062621
71Absent radius (HP:0003974)2.03000420
72Prostate neoplasm (HP:0100787)2.02930486
73Increased nuchal translucency (HP:0010880)2.02817911
74Preaxial hand polydactyly (HP:0001177)2.02476494
75Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.02154524
76Abnormal protein N-linked glycosylation (HP:0012347)2.02154524
77Abnormal protein glycosylation (HP:0012346)2.02154524
78Abnormal glycosylation (HP:0012345)2.02154524
79Increased serum lactate (HP:0002151)2.00567336
80Hypoplastic pelvis (HP:0008839)2.00214798
81Microretrognathia (HP:0000308)2.00188217
82Triphalangeal thumb (HP:0001199)1.99539186
83Hyperglycinuria (HP:0003108)1.99511112
84Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99508702
85Abnormality of alanine metabolism (HP:0010916)1.99508702
86Hyperalaninemia (HP:0003348)1.99508702
87Abnormality of methionine metabolism (HP:0010901)1.99407240
88Agnosia (HP:0010524)1.98076270
89Abnormal spermatogenesis (HP:0008669)1.97795944
90Horseshoe kidney (HP:0000085)1.97668788
91Abnormality of the musculature of the pelvis (HP:0001469)1.95255437
92Abnormality of the hip-girdle musculature (HP:0001445)1.95255437
93Cerebral edema (HP:0002181)1.93387630
94Aplasia/Hypoplasia of the sternum (HP:0006714)1.92900176
95Spinal cord lesions (HP:0100561)1.92036378
96Syringomyelia (HP:0003396)1.92036378
97Hepatocellular necrosis (HP:0001404)1.91849516
98Facial cleft (HP:0002006)1.91826790
99Progressive macrocephaly (HP:0004481)1.91588137
100Abnormality of the duodenum (HP:0002246)1.91345584
101Exertional dyspnea (HP:0002875)1.90354550
102Methylmalonic aciduria (HP:0012120)1.90284323
103Pelvic girdle muscle weakness (HP:0003749)1.90254446
104Abnormality of the metopic suture (HP:0005556)1.89194909
105Lipid accumulation in hepatocytes (HP:0006561)1.88145643
106Abnormality of the prostate (HP:0008775)1.87992890
107Tracheoesophageal fistula (HP:0002575)1.87914185
108Pulmonary fibrosis (HP:0002206)1.87406395
109Proximal placement of thumb (HP:0009623)1.87362618
110Cleft eyelid (HP:0000625)1.87308539
111Rectal fistula (HP:0100590)1.87294107
112Rectovaginal fistula (HP:0000143)1.87294107
113Rimmed vacuoles (HP:0003805)1.86979232
114Short middle phalanx of the 5th finger (HP:0004220)1.86795765
115Abnormality of the columella (HP:0009929)1.86052668
116Aplasia involving forearm bones (HP:0009822)1.85134930
117Absent forearm bone (HP:0003953)1.85134930
118Recurrent abscess formation (HP:0002722)1.85023308
119Amaurosis fugax (HP:0100576)1.84340191
120Tongue fasciculations (HP:0001308)1.83671173
121Sloping forehead (HP:0000340)1.83450881
122Neoplasm of the colon (HP:0100273)1.83128494
123Acute myeloid leukemia (HP:0004808)1.82149091
124Medulloblastoma (HP:0002885)1.82027188
125Increased serum pyruvate (HP:0003542)1.80813644
126Short thumb (HP:0009778)1.79571490
127Abnormal hair whorl (HP:0010721)1.78836411
128Congenital primary aphakia (HP:0007707)1.77809036
129Retinal dysplasia (HP:0007973)1.77551637
130Abnormality of glycolysis (HP:0004366)1.77145323
131Abnormal trabecular bone morphology (HP:0100671)1.76885433
132Acute lymphatic leukemia (HP:0006721)1.76425412
133Sparse eyelashes (HP:0000653)1.76286985
134Neoplasm of the pancreas (HP:0002894)1.76278129
135Pancytopenia (HP:0001876)1.76164648
136Postnatal microcephaly (HP:0005484)1.76069889
137Poikiloderma (HP:0001029)1.75749063
138Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.75272174
139Medial flaring of the eyebrow (HP:0010747)1.75187479
140Facial hemangioma (HP:0000329)1.74546955
141Stenosis of the external auditory canal (HP:0000402)1.74545549
142Lactic acidosis (HP:0003128)1.74526943
143Intestinal fistula (HP:0100819)1.73714427
144Pallor (HP:0000980)1.72797647
145Hepatic necrosis (HP:0002605)1.72092921
146IgA deficiency (HP:0002720)1.71862487
147Oligodactyly (hands) (HP:0001180)1.71426496
148Pendular nystagmus (HP:0012043)1.69686320
149Median cleft lip (HP:0000161)1.69543491
150Bifid tongue (HP:0010297)1.69123265
151Myositis (HP:0100614)1.68882688
152Poor head control (HP:0002421)1.68862861
153Cutaneous melanoma (HP:0012056)1.67260046
154Hypoplasia of the radius (HP:0002984)1.66566472
155Abnormality of the astrocytes (HP:0100707)1.66389192
156Astrocytoma (HP:0009592)1.66389192
157Neoplasm of the adrenal gland (HP:0100631)1.66050629
158Oligodactyly (HP:0012165)1.65587401
159Glioma (HP:0009733)1.65216832
160Abnormality of the carotid arteries (HP:0005344)1.64323780
161Intestinal atresia (HP:0011100)1.63513440
162Petechiae (HP:0000967)1.62535125
163Elevated erythrocyte sedimentation rate (HP:0003565)1.61562308
164Abnormality of DNA repair (HP:0003254)1.61322636

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE13.36328494
2BUB13.26296274
3TRIM283.20555190
4EIF2AK13.02255002
5SRPK12.91305757
6CDK192.66582322
7BRSK22.66048904
8MKNK12.57472558
9PLK42.52457323
10ACVR1B2.48605910
11STK162.39490083
12MKNK22.37132122
13EIF2AK32.33449555
14CDC72.29692934
15VRK12.22944197
16PIM22.20565957
17MAP4K22.13785992
18VRK22.05912294
19ZAK1.87410313
20WNK31.83184682
21NME21.80468729
22IRAK41.72186235
23BCKDK1.64321721
24DYRK31.58839154
25PLK11.58799740
26YES11.56672005
27TXK1.56432408
28CDK71.52458099
29PLK31.49877246
30MAP3K141.45864082
31MAP3K41.40052940
32ATR1.39751570
33PDK21.39700283
34PIM11.39181262
35PNCK1.39163319
36EIF2AK21.39052883
37TLK11.38302602
38SIK31.37741967
39BRSK11.37724429
40NEK21.32861182
41TGFBR11.32178050
42TAF11.31502097
43RPS6KA41.29033889
44AURKB1.28688071
45IRAK31.28513179
46MAP2K71.26359600
47ERBB31.25295846
48JAK31.22213083
49CSNK1G11.21932870
50STK38L1.21694206
51CHEK21.19503412
52CSNK1G31.18799806
53IKBKB1.16029436
54TSSK61.14993869
55CCNB11.13751200
56STK41.12685592
57CDK81.11926683
58CSNK1G21.11113435
59PASK1.09150943
60MAP4K11.07266060
61BMPR1B1.04796203
62TEC1.04693886
63CHUK1.04436465
64RPS6KB21.03276648
65TNIK1.00815053
66CSNK1A1L1.00277516
67MUSK0.99313671
68TTK0.99012995
69AKT30.98712036
70PLK20.91229747
71OXSR10.87648775
72STK240.85380477
73DYRK20.82901036
74AURKA0.79519530
75KIT0.77499709
76CHEK10.76714571
77MST40.72816886
78CLK10.72749501
79EPHA40.72673994
80CSNK2A10.72639225
81IKBKE0.72559532
82BRD40.71544282
83NLK0.71375808
84NEK60.70716480
85PBK0.70536963
86NEK90.70164605
87CDK40.69141934
88TESK20.68256153
89ATM0.67088890
90NME10.65363968
91NUAK10.64934710
92CDK30.63208277
93TYK20.62710416
94TRPM70.62221475
95ZAP700.61731115
96BTK0.61256450
97TAOK20.61057297
98MATK0.60492385
99TIE10.59977313
100FLT30.59668088
101NEK10.59651667
102STK30.57923867
103MAP3K110.56016071
104CDK20.55365848
105KDR0.52586474
106BLK0.51095352
107MAP3K60.49194125
108CSNK1E0.49069614
109STK390.48581549
110RPS6KA60.47705632
111LYN0.47529004
112CSNK2A20.47294819
113PRKDC0.46532165
114BRAF0.45662289
115CDK140.45161503
116RPS6KC10.44646888
117RPS6KL10.44646888
118MAP2K30.44015991
119ADRBK20.43919772
120MINK10.43795603
121BMPR20.43791702
122CDK180.43583106
123CDK11A0.43359387
124RPS6KA50.42528154
125ERBB40.41784800
126STK100.41551608
127MAP3K80.41271241
128BCR0.40582762
129TBK10.39280323
130SYK0.38851024
131KSR10.38720058
132SCYL20.38557035
133CDK10.38184690
134GRK10.36757619
135RPS6KB10.36314418
136PAK40.35855484
137FGFR10.35397309
138CDK150.35328147
139CDK90.33272062
140RAF10.33034727
141MAP3K100.30288465
142PRKCI0.30210533
143DAPK10.28879638

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.29017087
2Mismatch repair_Homo sapiens_hsa034303.75277272
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.30309483
4RNA polymerase_Homo sapiens_hsa030203.25813472
5Base excision repair_Homo sapiens_hsa034103.12428992
6Proteasome_Homo sapiens_hsa030502.93054649
7Homologous recombination_Homo sapiens_hsa034402.91367819
8Spliceosome_Homo sapiens_hsa030402.88907950
9Ribosome_Homo sapiens_hsa030102.70685229
10Nucleotide excision repair_Homo sapiens_hsa034202.68115450
11RNA transport_Homo sapiens_hsa030132.51494311
12Cell cycle_Homo sapiens_hsa041102.49260088
13Fanconi anemia pathway_Homo sapiens_hsa034602.33381753
14Pyrimidine metabolism_Homo sapiens_hsa002402.26482857
15Basal transcription factors_Homo sapiens_hsa030222.25666160
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.06657942
17Cysteine and methionine metabolism_Homo sapiens_hsa002701.92563303
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.89830992
19RNA degradation_Homo sapiens_hsa030181.82484271
20Parkinsons disease_Homo sapiens_hsa050121.82089424
21Oxidative phosphorylation_Homo sapiens_hsa001901.78572724
22Non-homologous end-joining_Homo sapiens_hsa034501.76854581
23p53 signaling pathway_Homo sapiens_hsa041151.74967878
24One carbon pool by folate_Homo sapiens_hsa006701.72942186
25Propanoate metabolism_Homo sapiens_hsa006401.66524694
26Fatty acid elongation_Homo sapiens_hsa000621.56889573
27Steroid biosynthesis_Homo sapiens_hsa001001.55882876
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.54730652
29mRNA surveillance pathway_Homo sapiens_hsa030151.50143662
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.46234090
31Herpes simplex infection_Homo sapiens_hsa051681.42655421
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.40148416
33Pyruvate metabolism_Homo sapiens_hsa006201.34003308
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31347450
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.29617768
36Epstein-Barr virus infection_Homo sapiens_hsa051691.28746085
37Purine metabolism_Homo sapiens_hsa002301.24887216
38Allograft rejection_Homo sapiens_hsa053301.24406300
39Primary immunodeficiency_Homo sapiens_hsa053401.19433359
40Protein export_Homo sapiens_hsa030601.19240412
41Biosynthesis of amino acids_Homo sapiens_hsa012301.19012410
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.16565296
43Antigen processing and presentation_Homo sapiens_hsa046121.11744615
44Graft-versus-host disease_Homo sapiens_hsa053321.11525420
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.11146976
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10949912
47Legionellosis_Homo sapiens_hsa051341.08494439
48Measles_Homo sapiens_hsa051621.06158464
49NF-kappa B signaling pathway_Homo sapiens_hsa040641.05757837
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99416616
51Carbon metabolism_Homo sapiens_hsa012000.98555599
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94658613
53Thyroid cancer_Homo sapiens_hsa052160.91724272
54Systemic lupus erythematosus_Homo sapiens_hsa053220.90121025
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85749507
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85019344
57Viral carcinogenesis_Homo sapiens_hsa052030.84741487
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83101419
59Leishmaniasis_Homo sapiens_hsa051400.80660503
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80371382
61Influenza A_Homo sapiens_hsa051640.79243556
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78936688
63Shigellosis_Homo sapiens_hsa051310.78288699
64Alzheimers disease_Homo sapiens_hsa050100.77851215
65NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73694234
66Autoimmune thyroid disease_Homo sapiens_hsa053200.73134770
67HTLV-I infection_Homo sapiens_hsa051660.71957182
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70904455
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70782335
70Folate biosynthesis_Homo sapiens_hsa007900.68696456
71Hepatitis B_Homo sapiens_hsa051610.66837055
72Apoptosis_Homo sapiens_hsa042100.66534766
73Asthma_Homo sapiens_hsa053100.66480046
74Metabolic pathways_Homo sapiens_hsa011000.62553326
75Hematopoietic cell lineage_Homo sapiens_hsa046400.61558364
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61487963
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.58528856
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.56014018
79Fatty acid metabolism_Homo sapiens_hsa012120.55309283
80MicroRNAs in cancer_Homo sapiens_hsa052060.54673562
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54515326
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54477110
83TGF-beta signaling pathway_Homo sapiens_hsa043500.54050395
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53994851
85Arachidonic acid metabolism_Homo sapiens_hsa005900.51464511
86Small cell lung cancer_Homo sapiens_hsa052220.51190387
87Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50274221
88N-Glycan biosynthesis_Homo sapiens_hsa005100.49415009
89Oocyte meiosis_Homo sapiens_hsa041140.47635378
90Notch signaling pathway_Homo sapiens_hsa043300.46351274
91Peroxisome_Homo sapiens_hsa041460.45997904
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45880125
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45688969
94Viral myocarditis_Homo sapiens_hsa054160.45642433
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44723968
96Type I diabetes mellitus_Homo sapiens_hsa049400.42545752
97Butanoate metabolism_Homo sapiens_hsa006500.41807698
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.41151706
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40802275
100Basal cell carcinoma_Homo sapiens_hsa052170.39981001
101Arginine and proline metabolism_Homo sapiens_hsa003300.39812550
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38633308
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38482376
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38418323
105Acute myeloid leukemia_Homo sapiens_hsa052210.37768230
106Pertussis_Homo sapiens_hsa051330.37323254
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36811253
108Regulation of autophagy_Homo sapiens_hsa041400.36174288
109Hedgehog signaling pathway_Homo sapiens_hsa043400.35700231
110Huntingtons disease_Homo sapiens_hsa050160.35235499
111Sulfur relay system_Homo sapiens_hsa041220.34616787
112Pentose phosphate pathway_Homo sapiens_hsa000300.34154146
113Selenocompound metabolism_Homo sapiens_hsa004500.33612487
114Colorectal cancer_Homo sapiens_hsa052100.33231323
115TNF signaling pathway_Homo sapiens_hsa046680.33160373
116Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32147493
117Lysine degradation_Homo sapiens_hsa003100.31617577
118Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31020624
119Wnt signaling pathway_Homo sapiens_hsa043100.30148840
120Collecting duct acid secretion_Homo sapiens_hsa049660.29757912
121Phototransduction_Homo sapiens_hsa047440.29713451
122Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29103105
123beta-Alanine metabolism_Homo sapiens_hsa004100.28790317
124Vitamin B6 metabolism_Homo sapiens_hsa007500.28732100
125Malaria_Homo sapiens_hsa051440.28638499
126Glutathione metabolism_Homo sapiens_hsa004800.28390953
127Salmonella infection_Homo sapiens_hsa051320.27584268
128Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27431664
129Hippo signaling pathway_Homo sapiens_hsa043900.27355156
130Toxoplasmosis_Homo sapiens_hsa051450.27171749
131Chronic myeloid leukemia_Homo sapiens_hsa052200.26747407
132Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.24024828
133T cell receptor signaling pathway_Homo sapiens_hsa046600.23700316
134Pathways in cancer_Homo sapiens_hsa052000.23453833
135B cell receptor signaling pathway_Homo sapiens_hsa046620.23320107
136Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23293232
137Vibrio cholerae infection_Homo sapiens_hsa051100.22317626
138Other glycan degradation_Homo sapiens_hsa005110.22122061
139Vitamin digestion and absorption_Homo sapiens_hsa049770.21712803
140Cardiac muscle contraction_Homo sapiens_hsa042600.21309266
141Tuberculosis_Homo sapiens_hsa051520.20883159
142Sulfur metabolism_Homo sapiens_hsa009200.19865560
143Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17672512
144Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.16631401
145Alcoholism_Homo sapiens_hsa050340.12183468
146Tight junction_Homo sapiens_hsa045300.10423651
147Fatty acid degradation_Homo sapiens_hsa000710.09335804

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