ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chaperone-mediated protein transport (GO:0072321)	7.89936971
2	viral transcription (GO:0019083)	6.94660637
3	GDP-mannose metabolic process (GO:0019673)	6.93181208
4	translational termination (GO:0006415)	6.60245083
5	nucleoside transmembrane transport (GO:1901642)	6.40089164
6	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.00529143
7	ATP synthesis coupled proton transport (GO:0015986)	6.00529143
8	ribosomal small subunit biogenesis (GO:0042274)	5.82445054
9	ribosomal small subunit assembly (GO:0000028)	5.70412908
10	translational elongation (GO:0006414)	5.68571211
11	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.58834502
12	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.47688010
13	cotranslational protein targeting to membrane (GO:0006613)	5.46351369
14	protein targeting to ER (GO:0045047)	5.41359987
15	behavioral response to nicotine (GO:0035095)	5.32279297
16	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.13871297
17	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.10114093
18	protein localization to endoplasmic reticulum (GO:0070972)	5.03093542
19	viral life cycle (GO:0019058)	4.99602582
20	nucleoside transport (GO:0015858)	4.95560837
21	cellular protein complex disassembly (GO:0043624)	4.91272072
22	maturation of SSU-rRNA (GO:0030490)	4.90939644
23	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.79745587
24	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.77238105
25	DNA deamination (GO:0045006)	4.74701153
26	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.60127412
27	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.60127412
28	mannose metabolic process (GO:0006013)	4.56780324
29	protein complex disassembly (GO:0043241)	4.03487604
30	translational initiation (GO:0006413)	3.99622621
31	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.96873456
32	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.95131304
33	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.85658116
34	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.83025245
35	epithelial cilium movement (GO:0003351)	3.79374181
36	macromolecular complex disassembly (GO:0032984)	3.77311134
37	protein targeting to membrane (GO:0006612)	3.76677444
38	protein complex biogenesis (GO:0070271)	3.76275698
39	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.73826870
40	respiratory electron transport chain (GO:0022904)	3.70790075
41	electron transport chain (GO:0022900)	3.66801357
42	forebrain morphogenesis (GO:0048853)	3.64529252
43	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	3.55535832
44	mRNA catabolic process (GO:0006402)	3.52316837
45	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.51883593
46	interferon-gamma production (GO:0032609)	3.49922835
47	otic vesicle formation (GO:0030916)	3.49067485
48	intracellular protein transmembrane import (GO:0044743)	3.45647856
49	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.44428292
50	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.42480755
51	mitochondrial respiratory chain complex assembly (GO:0033108)	3.39213078
52	membrane repolarization during action potential (GO:0086011)	3.34173745
53	cell proliferation in forebrain (GO:0021846)	3.30732937
54	translation (GO:0006412)	3.30487470
55	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.26936341
56	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.26936341
57	NADH dehydrogenase complex assembly (GO:0010257)	3.26936341
58	outer ear morphogenesis (GO:0042473)	3.24857272
59	positive regulation of icosanoid secretion (GO:0032305)	3.23725437
60	ATP biosynthetic process (GO:0006754)	3.21046824
61	cofactor transport (GO:0051181)	3.20772674
62	lateral ventricle development (GO:0021670)	3.14469926
63	cytidine metabolic process (GO:0046087)	3.12742738
64	cytidine catabolic process (GO:0006216)	3.12742738
65	cytidine deamination (GO:0009972)	3.12742738
66	cellular component biogenesis (GO:0044085)	3.10148679
67	transmission of nerve impulse (GO:0019226)	3.08782692
68	RNA catabolic process (GO:0006401)	3.07499828
69	positive regulation of fatty acid transport (GO:2000193)	3.04305770
70	sequestering of actin monomers (GO:0042989)	2.95621932
71	protein neddylation (GO:0045116)	2.95388356
72	inner mitochondrial membrane organization (GO:0007007)	2.90533454
73	modified amino acid transport (GO:0072337)	2.86627783
74	kidney morphogenesis (GO:0060993)	2.85181709
75	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.85040735
76	cilium movement (GO:0003341)	2.84135907
77	reproduction (GO:0000003)	2.84111025
78	short-chain fatty acid metabolic process (GO:0046459)	2.81406914
79	regulation of cilium movement (GO:0003352)	2.80426345
80	hydrogen ion transmembrane transport (GO:1902600)	2.79597294
81	ribosomal large subunit biogenesis (GO:0042273)	2.79098841
82	somite development (GO:0061053)	2.76014193
83	membrane repolarization (GO:0086009)	2.73972030
84	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.73614919
85	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.71667896
86	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.68129033
87	enteric nervous system development (GO:0048484)	2.66089790
88	intracellular protein transmembrane transport (GO:0065002)	2.64898920
89	platelet dense granule organization (GO:0060155)	2.62700769
90	regulation of mitochondrial membrane potential (GO:0051881)	2.60306769
91	protein localization to peroxisome (GO:0072662)	2.59319766
92	protein targeting to peroxisome (GO:0006625)	2.59319766
93	establishment of protein localization to peroxisome (GO:0072663)	2.59319766
94	peroxisome fission (GO:0016559)	2.58776980
95	aerobic respiration (GO:0009060)	2.57005345
96	proton transport (GO:0015992)	2.53486388
97	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.52888906
98	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.52888906
99	regulation of transcription regulatory region DNA binding (GO:2000677)	2.51704494
100	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.50749223

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	7.18098497
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.87693701
3	EZH2_22144423_ChIP-Seq_EOC_Human	4.64848152
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.67095641
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.30813206
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.88630679
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.77717479
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.61145688
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.54975514
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.21306230
11	IRF1_19129219_ChIP-ChIP_H3396_Human	2.09674938
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.99033571
13	ZNF274_21170338_ChIP-Seq_K562_Hela	1.98816702
14	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.95121924
15	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.93815019
16	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.93807195
17	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.91691750
18	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.83533854
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.83130692
20	IGF1R_20145208_ChIP-Seq_DFB_Human	1.76005737
21	RNF2_27304074_Chip-Seq_NSC_Mouse	1.70959044
22	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.69341553
23	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.68933034
24	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.67854392
25	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.66264075
26	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.59865084
27	EWS_26573619_Chip-Seq_HEK293_Human	1.56801306
28	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.53646896
29	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.50972102
30	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.49578112
31	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.49347821
32	FUS_26573619_Chip-Seq_HEK293_Human	1.46380363
33	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.46119466
34	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.45660990
35	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.42264561
36	HTT_18923047_ChIP-ChIP_STHdh_Human	1.42205456
37	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.38667127
38	VDR_23849224_ChIP-Seq_CD4+_Human	1.36235518
39	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.36202173
40	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.35585182
41	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.35335776
42	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.33239249
43	VDR_22108803_ChIP-Seq_LS180_Human	1.32981263
44	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.31537841
45	ELK1_19687146_ChIP-ChIP_HELA_Human	1.29997443
46	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.29734977
47	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.27600814
48	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.27350612
49	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.27162965
50	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.27140042
51	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.18672806
52	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.18062909
53	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.16979019
54	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.15600942
55	TTF2_22483619_ChIP-Seq_HELA_Human	1.15215213
56	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.14548442
57	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.13128004
58	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.11374220
59	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.09601467
60	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.08307265
61	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.07492544
62	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.07323360
63	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.06664292
64	TP53_22573176_ChIP-Seq_HFKS_Human	1.04345267
65	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.03954608
66	MYC_18940864_ChIP-ChIP_HL60_Human	1.03896776
67	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.02952233
68	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.02210723
69	CBP_20019798_ChIP-Seq_JUKART_Human	1.01986935
70	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.01986935
71	NANOG_20526341_ChIP-Seq_ESCs_Human	1.01942105
72	REST_21632747_ChIP-Seq_MESCs_Mouse	1.01758091
73	TAF15_26573619_Chip-Seq_HEK293_Human	1.01350487
74	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.01189954
75	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.00858938
76	FOXP3_21729870_ChIP-Seq_TREG_Human	1.00577534
77	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.99882299
78	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.99683079
79	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.99519436
80	NCOR_22424771_ChIP-Seq_293T_Human	0.98354709
81	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.98299955
82	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.98293789
83	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.97779003
84	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.97551602
85	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.97278612
86	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.97278612
87	XRN2_22483619_ChIP-Seq_HELA_Human	0.97217156
88	P300_19829295_ChIP-Seq_ESCs_Human	0.97125764
89	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95470995
90	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.94570649
91	MYC_19829295_ChIP-Seq_ESCs_Human	0.94176973
92	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93366583
93	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.93366583
94	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.93037884
95	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.92512557
96	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.92100189
97	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.92043046
98	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.91907444
99	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.90820408
100	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.89377892

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.48509887
2	MP0002638_abnormal_pupillary_reflex	4.42666067
3	MP0006292_abnormal_olfactory_placode	3.74453821
4	MP0003646_muscle_fatigue	3.52183373
5	MP0003122_maternal_imprinting	3.00699682
6	MP0010030_abnormal_orbit_morphology	2.81394778
7	MP0006072_abnormal_retinal_apoptosis	2.42723140
8	MP0003136_yellow_coat_color	2.41840060
9	MP0008789_abnormal_olfactory_epithelium	2.39592665
10	MP0003011_delayed_dark_adaptation	2.04284721
11	MP0001485_abnormal_pinna_reflex	2.02117344
12	MP0005377_hearing/vestibular/ear_phenot	2.01655552
13	MP0003878_abnormal_ear_physiology	2.01655552
14	MP0004133_heterotaxia	1.99486018
15	MP0002938_white_spotting	1.98409553
16	MP0000049_abnormal_middle_ear	1.96028152
17	MP0005394_taste/olfaction_phenotype	1.89860028
18	MP0005499_abnormal_olfactory_system	1.89860028
19	MP0002837_dystrophic_cardiac_calcinosis	1.86018686
20	MP0000566_synostosis	1.84285180
21	MP0001293_anophthalmia	1.82792439
22	MP0003890_abnormal_embryonic-extraembry	1.79818197
23	MP0002160_abnormal_reproductive_system	1.76657573
24	MP0002234_abnormal_pharynx_morphology	1.71295640
25	MP0004142_abnormal_muscle_tone	1.67187781
26	MP0005645_abnormal_hypothalamus_physiol	1.66197372
27	MP0000778_abnormal_nervous_system	1.58984774
28	MP0008877_abnormal_DNA_methylation	1.55986514
29	MP0005253_abnormal_eye_physiology	1.55800125
30	MP0003880_abnormal_central_pattern	1.55577051
31	MP0003121_genomic_imprinting	1.54536200
32	MP0002102_abnormal_ear_morphology	1.53404546
33	MP0001529_abnormal_vocalization	1.49889216
34	MP0000631_abnormal_neuroendocrine_gland	1.44587611
35	MP0000372_irregular_coat_pigmentation	1.41058532
36	MP0005551_abnormal_eye_electrophysiolog	1.39152489
37	MP0002163_abnormal_gland_morphology	1.37410590
38	MP0003938_abnormal_ear_development	1.35625256
39	MP0002653_abnormal_ependyma_morphology	1.35420710
40	MP0005084_abnormal_gallbladder_morpholo	1.31791084
41	MP0000026_abnormal_inner_ear	1.28310668
42	MP0003787_abnormal_imprinting	1.28135648
43	MP0009250_abnormal_appendicular_skeleto	1.27928442
44	MP0008995_early_reproductive_senescence	1.27471917
45	MP0005671_abnormal_response_to	1.26964823
46	MP0004145_abnormal_muscle_electrophysio	1.22360946
47	MP0001542_abnormal_bone_strength	1.21311701
48	MP0001986_abnormal_taste_sensitivity	1.17799684
49	MP0004885_abnormal_endolymph	1.16583571
50	MP0005423_abnormal_somatic_nervous	1.15608312
51	MP0001502_abnormal_circadian_rhythm	1.15362607
52	MP0005195_abnormal_posterior_eye	1.14032788
53	MP0005389_reproductive_system_phenotype	1.12065720
54	MP0001905_abnormal_dopamine_level	1.11270791
55	MP0001727_abnormal_embryo_implantation	1.09914219
56	MP0006276_abnormal_autonomic_nervous	1.08265141
57	MP0002277_abnormal_respiratory_mucosa	1.08204687
58	MP0005391_vision/eye_phenotype	1.03160955
59	MP0002233_abnormal_nose_morphology	0.99327354
60	MP0002272_abnormal_nervous_system	0.98600519
61	MP0004742_abnormal_vestibular_system	0.97048686
62	MP0002928_abnormal_bile_duct	0.96830394
63	MP0002822_catalepsy	0.95799723
64	MP0009745_abnormal_behavioral_response	0.95117310
65	MP0002249_abnormal_larynx_morphology	0.91369804
66	MP0002752_abnormal_somatic_nervous	0.90145388
67	MP0001346_abnormal_lacrimal_gland	0.89981486
68	MP0000537_abnormal_urethra_morphology	0.88009482
69	MP0004043_abnormal_pH_regulation	0.87816949
70	MP0002557_abnormal_social/conspecific_i	0.87618843
71	MP0004215_abnormal_myocardial_fiber	0.87594613
72	MP0003937_abnormal_limbs/digits/tail_de	0.86007962
73	MP0001963_abnormal_hearing_physiology	0.83349549
74	MP0001188_hyperpigmentation	0.83248920
75	MP0001968_abnormal_touch/_nociception	0.82503631
76	MP0005410_abnormal_fertilization	0.81671852
77	MP0009046_muscle_twitch	0.81540457
78	MP0003567_abnormal_fetal_cardiomyocyte	0.80174548
79	MP0002733_abnormal_thermal_nociception	0.77355158
80	MP0002210_abnormal_sex_determination	0.76659133
81	MP0001286_abnormal_eye_development	0.75974931
82	MP0000579_abnormal_nail_morphology	0.74591042
83	MP0008872_abnormal_physiological_respon	0.73283892
84	MP0001440_abnormal_grooming_behavior	0.72165219
85	MP0002095_abnormal_skin_pigmentation	0.71297303
86	MP0008775_abnormal_heart_ventricle	0.69963065
87	MP0009764_decreased_sensitivity_to	0.67965742
88	MP0000955_abnormal_spinal_cord	0.67368550
89	MP0003638_abnormal_response/metabolism_	0.67260520
90	MP0002572_abnormal_emotion/affect_behav	0.66777784
91	MP0005379_endocrine/exocrine_gland_phen	0.65284966
92	MP0002735_abnormal_chemical_nociception	0.65237183
93	MP0001984_abnormal_olfaction	0.64770993
94	MP0002184_abnormal_innervation	0.64530452
95	MP0003942_abnormal_urinary_system	0.62581512
96	MP0003315_abnormal_perineum_morphology	0.62203332
97	MP0003119_abnormal_digestive_system	0.61950649
98	MP0002736_abnormal_nociception_after	0.61895645
99	MP0001970_abnormal_pain_threshold	0.61626126
100	MP0004019_abnormal_vitamin_homeostasis	0.61067043

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Global brain atrophy (HP:0002283)	5.16366559
2	Hyperglycinemia (HP:0002154)	4.07602720
3	Abnormality of the phalanges of the 2nd finger (HP:0009541)	3.99007656
4	Reticulocytopenia (HP:0001896)	3.56382034
5	Increased hepatocellular lipid droplets (HP:0006565)	3.50413700
6	Mitochondrial inheritance (HP:0001427)	3.45220876
7	Abnormality of cells of the erythroid lineage (HP:0012130)	3.42687466
8	Neurodegeneration (HP:0002180)	3.21225489
9	Macrocytic anemia (HP:0001972)	3.17619986
10	Acute necrotizing encephalopathy (HP:0006965)	3.17084817
11	Patent foramen ovale (HP:0001655)	3.10770112
12	Lipid accumulation in hepatocytes (HP:0006561)	3.10082085
13	Pancreatic fibrosis (HP:0100732)	3.09887133
14	Methylmalonic acidemia (HP:0002912)	3.01792125
15	Increased CSF lactate (HP:0002490)	2.98682393
16	Congenital stationary night blindness (HP:0007642)	2.98358776
17	Hypobetalipoproteinemia (HP:0003563)	2.94219014
18	Abnormality of midbrain morphology (HP:0002418)	2.85195452
19	Molar tooth sign on MRI (HP:0002419)	2.85195452
20	Abnormal respiratory epithelium morphology (HP:0012253)	2.82390767
21	Abnormal respiratory motile cilium morphology (HP:0005938)	2.82390767
22	Acute encephalopathy (HP:0006846)	2.79214713
23	Abnormal mitochondria in muscle tissue (HP:0008316)	2.79168181
24	Nephronophthisis (HP:0000090)	2.73825480
25	Hepatocellular necrosis (HP:0001404)	2.71883395
26	3-Methylglutaconic aciduria (HP:0003535)	2.70312239
27	Renal Fanconi syndrome (HP:0001994)	2.68870578
28	Partial duplication of the phalanx of hand (HP:0009999)	2.67562767
29	Dysphonia (HP:0001618)	2.62634148
30	Dyskinesia (HP:0100660)	2.62127690
31	Stenosis of the external auditory canal (HP:0000402)	2.61502436
32	Hepatic necrosis (HP:0002605)	2.60564102
33	Delayed CNS myelination (HP:0002188)	2.59522538
34	Progressive macrocephaly (HP:0004481)	2.56808579
35	Pancreatic cysts (HP:0001737)	2.54186863
36	Medial flaring of the eyebrow (HP:0010747)	2.52836821
37	Brushfield spots (HP:0001088)	2.51355157
38	Abnormal number of erythroid precursors (HP:0012131)	2.49711378
39	Septo-optic dysplasia (HP:0100842)	2.49062737
40	Akinesia (HP:0002304)	2.46161870
41	Abnormality of renal resorption (HP:0011038)	2.42313689
42	Abnormality of the parietal bone (HP:0002696)	2.40880972
43	Pallor (HP:0000980)	2.39333212
44	Coronal craniosynostosis (HP:0004440)	2.37043450
45	Increased intramyocellular lipid droplets (HP:0012240)	2.32935710
46	Acanthocytosis (HP:0001927)	2.32815462
47	Abnormality of the renal medulla (HP:0100957)	2.30431371
48	Broad distal phalanx of finger (HP:0009836)	2.28675829
49	Hemiplegia (HP:0002301)	2.26584300
50	Congenital, generalized hypertrichosis (HP:0004540)	2.26129234
51	Concave nail (HP:0001598)	2.26096293
52	Agitation (HP:0000713)	2.24529342
53	Abnormal ciliary motility (HP:0012262)	2.23998855
54	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.19546065
55	Rib fusion (HP:0000902)	2.17751034
56	Glycosuria (HP:0003076)	2.16950999
57	Abnormality of urine glucose concentration (HP:0011016)	2.16950999
58	Gait imbalance (HP:0002141)	2.16188642
59	Hypoplasia of the pons (HP:0012110)	2.15785789
60	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.14849481
61	Congenital primary aphakia (HP:0007707)	2.12101744
62	Restlessness (HP:0000711)	2.08955577
63	Methylmalonic aciduria (HP:0012120)	2.08149875
64	Hypoplasia of the ulna (HP:0003022)	2.06170470
65	Abnormality of the labia minora (HP:0012880)	2.04893435
66	Abnormality of the 2nd finger (HP:0004100)	2.03781379
67	Abnormality of the middle phalanges of the toes (HP:0010183)	2.02029444
68	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.00516390
69	Tubulointerstitial nephritis (HP:0001970)	1.98679921
70	Small hand (HP:0200055)	1.98593776
71	Decreased muscle mass (HP:0003199)	1.98426450
72	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.97673286
73	Aplasia/Hypoplasia of the hallux (HP:0008362)	1.96094884
74	Abnormality of the pons (HP:0007361)	1.96064166
75	Short tibia (HP:0005736)	1.91674142
76	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.89087528
77	Long nose (HP:0003189)	1.88017175
78	Absent thumb (HP:0009777)	1.87840386
79	Large eyes (HP:0001090)	1.87013238
80	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.86901169
81	Absent/shortened dynein arms (HP:0200106)	1.86901169
82	Exertional dyspnea (HP:0002875)	1.86787827
83	CNS demyelination (HP:0007305)	1.86430624
84	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.85729387
85	Respiratory difficulties (HP:0002880)	1.85380404
86	Abnormality of glycine metabolism (HP:0010895)	1.84309630
87	Abnormality of serine family amino acid metabolism (HP:0010894)	1.84309630
88	Increased muscle lipid content (HP:0009058)	1.83914275
89	Cerebral edema (HP:0002181)	1.83682169
90	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.83595846
91	True hermaphroditism (HP:0010459)	1.82197823
92	Nephrogenic diabetes insipidus (HP:0009806)	1.81233326
93	Abnormal respiratory motile cilium physiology (HP:0012261)	1.80101452
94	Abnormality of serum amino acid levels (HP:0003112)	1.79215032
95	Vaginal atresia (HP:0000148)	1.78579777
96	Short hallux (HP:0010109)	1.77410307
97	Genital tract atresia (HP:0001827)	1.77335712
98	Thyroid-stimulating hormone excess (HP:0002925)	1.77315279
99	Poor suck (HP:0002033)	1.75986750
100	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.73753460

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	3.87428516
2	GRK7	3.36882921
3	TRIM28	3.18283983
4	PDK2	2.86983426
5	NUAK1	2.86261996
6	FRK	2.50706179
7	TIE1	2.28901941
8	WNK3	2.28896165
9	MAPK15	2.28867564
10	ZAK	2.22265566
11	WNK4	2.16660254
12	VRK1	2.07557695
13	EPHB2	2.03218663
14	MAP4K2	1.98963938
15	SIK2	1.97676298
16	BMPR1B	1.96748900
17	TXK	1.90511855
18	PASK	1.87480580
19	ADRBK2	1.87189889
20	BCKDK	1.78978964
21	KDR	1.77103533
22	ERN1	1.69376469
23	TESK2	1.67398319
24	GRK1	1.61189287
25	INSRR	1.54605343
26	TLK1	1.51088476
27	TGFBR1	1.43974580
28	FGFR2	1.42784046
29	DYRK2	1.42604686
30	NEK2	1.40595372
31	ADRBK1	1.38848647
32	STK16	1.35273449
33	FES	1.29541598
34	STK39	1.26703091
35	MUSK	1.23094713
36	PINK1	1.13310933
37	CDC7	1.11486398
38	MAP2K6	1.07331954
39	MAP3K12	0.96776137
40	TAOK3	0.94284008
41	ARAF	0.91637634
42	NME1	0.90581813
43	PKN1	0.85345266
44	KIT	0.84956460
45	MATK	0.81289116
46	BRAF	0.76093989
47	LCK	0.74097741
48	PIM1	0.71684988
49	TAF1	0.70880221
50	PNCK	0.65975064
51	PRKCG	0.64865722
52	EPHA4	0.64376814
53	PRKCQ	0.64066651
54	CDK8	0.63845152
55	DAPK3	0.63434421
56	OBSCN	0.62669304
57	PRKACA	0.62354698
58	SGK494	0.61204591
59	SGK223	0.61204591
60	MAPK13	0.59938848
61	CHEK2	0.59905982
62	PLK3	0.59720226
63	AKT2	0.59536779
64	STK3	0.56864435
65	CDK19	0.55851422
66	CSNK2A1	0.50800962
67	STK38	0.49697582
68	BUB1	0.49555422
69	OXSR1	0.49393874
70	PIM2	0.48606932
71	MAP3K9	0.47879842
72	MAP2K2	0.45447164
73	ATR	0.44848821
74	LIMK1	0.44199826
75	ABL2	0.42676387
76	CAMK2A	0.42644680
77	PRKCA	0.40838772
78	PRKCE	0.40730284
79	IRAK1	0.40012168
80	INSR	0.39964250
81	PLK4	0.39490273
82	PRKCD	0.38531695
83	CSNK1A1	0.37929498
84	CSNK2A2	0.36134424
85	AURKA	0.35909971
86	MAP3K11	0.35596164
87	PIK3CA	0.34673624
88	MARK1	0.33885340
89	SYK	0.33530347
90	PRKG1	0.33077428
91	TEC	0.32913693
92	DYRK3	0.32811234
93	GRK5	0.32704664
94	PRKCH	0.32608601
95	NTRK2	0.32519324
96	FLT3	0.32222888
97	PLK2	0.31571596
98	PLK1	0.31467716
99	PAK3	0.29585842
100	RPS6KA4	0.29549438

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.39127253
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.56724057
3	Parkinsons disease_Homo sapiens_hsa05012	3.96836808
4	Cardiac muscle contraction_Homo sapiens_hsa04260	2.94092702
5	Huntingtons disease_Homo sapiens_hsa05016	2.64213306
6	Alzheimers disease_Homo sapiens_hsa05010	2.61258002
7	Proteasome_Homo sapiens_hsa03050	2.50113841
8	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.21937637
9	RNA degradation_Homo sapiens_hsa03018	2.18204514
10	RNA polymerase_Homo sapiens_hsa03020	2.11183826
11	Phototransduction_Homo sapiens_hsa04744	2.02776595
12	Sulfur metabolism_Homo sapiens_hsa00920	1.77954330
13	Linoleic acid metabolism_Homo sapiens_hsa00591	1.70688247
14	Primary immunodeficiency_Homo sapiens_hsa05340	1.47552308
15	Homologous recombination_Homo sapiens_hsa03440	1.41512178
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.41127008
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.39728653
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.36835268
19	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.35645637
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.30429005
21	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.27517201
22	Protein export_Homo sapiens_hsa03060	1.23496334
23	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.22398746
24	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.21976800
25	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.20726319
26	Nicotine addiction_Homo sapiens_hsa05033	1.17293554
27	Peroxisome_Homo sapiens_hsa04146	1.16613432
28	Mismatch repair_Homo sapiens_hsa03430	1.14846135
29	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.13324044
30	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.12329454
31	Base excision repair_Homo sapiens_hsa03410	1.10481638
32	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.07894198
33	Morphine addiction_Homo sapiens_hsa05032	1.07706092
34	Nitrogen metabolism_Homo sapiens_hsa00910	1.07651826
35	Selenocompound metabolism_Homo sapiens_hsa00450	1.07300688
36	DNA replication_Homo sapiens_hsa03030	1.07173470
37	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.01855111
38	Retinol metabolism_Homo sapiens_hsa00830	0.93301334
39	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.92259938
40	Spliceosome_Homo sapiens_hsa03040	0.85890661
41	Ether lipid metabolism_Homo sapiens_hsa00565	0.84732476
42	Olfactory transduction_Homo sapiens_hsa04740	0.83297178
43	Basal cell carcinoma_Homo sapiens_hsa05217	0.83168653
44	Fat digestion and absorption_Homo sapiens_hsa04975	0.82514080
45	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.81709655
46	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.80871307
47	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.78411242
48	Purine metabolism_Homo sapiens_hsa00230	0.78264128
49	Propanoate metabolism_Homo sapiens_hsa00640	0.77874986
50	Serotonergic synapse_Homo sapiens_hsa04726	0.77783515
51	Pyrimidine metabolism_Homo sapiens_hsa00240	0.77435284
52	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.75477743
53	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.72145246
54	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.71624745
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.71174791
56	Butanoate metabolism_Homo sapiens_hsa00650	0.70110740
57	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.69981691
58	Graft-versus-host disease_Homo sapiens_hsa05332	0.64969685
59	Tryptophan metabolism_Homo sapiens_hsa00380	0.63825479
60	Regulation of autophagy_Homo sapiens_hsa04140	0.63301525
61	Taste transduction_Homo sapiens_hsa04742	0.63204557
62	Metabolic pathways_Homo sapiens_hsa01100	0.62722481
63	Sulfur relay system_Homo sapiens_hsa04122	0.62321461
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.61668325
65	Non-homologous end-joining_Homo sapiens_hsa03450	0.59843675
66	Allograft rejection_Homo sapiens_hsa05330	0.59463895
67	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.55914905
68	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.55755449
69	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.54599494
70	Collecting duct acid secretion_Homo sapiens_hsa04966	0.53117468
71	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.52467302
72	GABAergic synapse_Homo sapiens_hsa04727	0.52080206
73	Asthma_Homo sapiens_hsa05310	0.51672208
74	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.51535869
75	Cholinergic synapse_Homo sapiens_hsa04725	0.49737362
76	Tyrosine metabolism_Homo sapiens_hsa00350	0.48025222
77	Glutathione metabolism_Homo sapiens_hsa00480	0.47975511
78	Fatty acid elongation_Homo sapiens_hsa00062	0.47052096
79	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.45701844
80	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.45138770
81	Type I diabetes mellitus_Homo sapiens_hsa04940	0.45123535
82	Rheumatoid arthritis_Homo sapiens_hsa05323	0.44449170
83	Glutamatergic synapse_Homo sapiens_hsa04724	0.44248974
84	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.43518196
85	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.43365794
86	Circadian entrainment_Homo sapiens_hsa04713	0.43143659
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.41995967
88	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.41391335
89	Folate biosynthesis_Homo sapiens_hsa00790	0.41294624
90	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.40450733
91	Notch signaling pathway_Homo sapiens_hsa04330	0.39074773
92	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.38699157
93	Phenylalanine metabolism_Homo sapiens_hsa00360	0.38137138
94	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.37337128
95	Nucleotide excision repair_Homo sapiens_hsa03420	0.35201957
96	Dopaminergic synapse_Homo sapiens_hsa04728	0.34742062
97	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.34453203
98	Basal transcription factors_Homo sapiens_hsa03022	0.34196971
99	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.31998453
100	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.31278690

YTHDF2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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