YTHDF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the YTH (YT521-B homology) domain protein family. The YTH domain is common in eukaryotes, is often found in the middle of the protein sequence, and may function in binding to RNA. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of oxidative stress-induced neuron death (GO:1903203)5.79314240
2negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.65181530
3positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.57373715
4response to muscle activity (GO:0014850)4.41895633
5paraxial mesoderm development (GO:0048339)4.27074054
6regulation of autophagic vacuole assembly (GO:2000785)4.22616592
7regulation of phosphoprotein phosphatase activity (GO:0043666)4.15880846
8positive regulation of catecholamine secretion (GO:0033605)4.11438830
9regulation of NFAT protein import into nucleus (GO:0051532)4.02282597
10regulation of vacuole organization (GO:0044088)3.80453933
11negative regulation of striated muscle cell apoptotic process (GO:0010664)3.76867908
12cytoplasmic mRNA processing body assembly (GO:0033962)3.69123399
13TOR signaling (GO:0031929)3.54870351
143-UTR-mediated mRNA stabilization (GO:0070935)3.51919608
15protein localization to cell surface (GO:0034394)3.50664156
16pre-miRNA processing (GO:0031054)3.50121249
17barbed-end actin filament capping (GO:0051016)3.46907559
18alpha-linolenic acid metabolic process (GO:0036109)3.38569377
19negative regulation of fibroblast apoptotic process (GO:2000270)3.36931936
20coenzyme catabolic process (GO:0009109)3.34245759
21myofibril assembly (GO:0030239)3.32485291
22mRNA cleavage (GO:0006379)3.24377896
23protein complex localization (GO:0031503)3.22339621
24histone demethylation (GO:0016577)3.19722314
25positive regulation of fatty acid beta-oxidation (GO:0032000)3.15633244
26cGMP-mediated signaling (GO:0019934)3.12661882
27lysine metabolic process (GO:0006553)3.11623154
28lysine catabolic process (GO:0006554)3.11623154
29cellular response to osmotic stress (GO:0071470)3.07446320
30regulation of transforming growth factor beta2 production (GO:0032909)3.06207732
31nuclear pore complex assembly (GO:0051292)3.03754460
32muscle cell cellular homeostasis (GO:0046716)3.01394448
33receptor recycling (GO:0001881)2.99270843
34glycogen metabolic process (GO:0005977)2.98679777
35cellular glucan metabolic process (GO:0006073)2.98290907
36glucan metabolic process (GO:0044042)2.98290907
37actin-mediated cell contraction (GO:0070252)2.97841728
38growth hormone receptor signaling pathway (GO:0060396)2.93725322
39muscle filament sliding (GO:0030049)2.93137880
40actin-myosin filament sliding (GO:0033275)2.93137880
41regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.88752290
42insulin-like growth factor receptor signaling pathway (GO:0048009)2.82501663
43homocysteine metabolic process (GO:0050667)2.82178543
44regulation of myoblast differentiation (GO:0045661)2.82164903
45actin filament-based movement (GO:0030048)2.81680085
46phospholipid homeostasis (GO:0055091)2.81609003
47urea cycle (GO:0000050)2.80577726
48urea metabolic process (GO:0019627)2.80577726
49AMP metabolic process (GO:0046033)2.79934000
50erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.79624496
51L-phenylalanine catabolic process (GO:0006559)2.79624496
52activation of protein kinase B activity (GO:0032148)2.79046062
53glucocorticoid receptor signaling pathway (GO:0042921)2.78737547
54cysteine metabolic process (GO:0006534)2.78477022
55regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.78176281
56protein dealkylation (GO:0008214)2.76752864
57protein demethylation (GO:0006482)2.76752864
58negative regulation of fibrinolysis (GO:0051918)2.74380046
59regulation of cholesterol homeostasis (GO:2000188)2.74203285
60regulation of fatty acid beta-oxidation (GO:0031998)2.74014182
61hippo signaling (GO:0035329)2.73620918
62cell adhesion mediated by integrin (GO:0033627)2.73291620
63regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.73219001
64triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.72499314
65radial glial cell differentiation (GO:0060019)2.70216626
66regulation of nucleobase-containing compound transport (GO:0032239)2.69119599
67negative regulation of fatty acid biosynthetic process (GO:0045717)2.68515772
68fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.67750548
69regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.67561306
70COPII vesicle coating (GO:0048208)2.66899616
71mitotic sister chromatid cohesion (GO:0007064)2.66859925
72nuclear pore organization (GO:0006999)2.65686246
73mesenchymal-epithelial cell signaling (GO:0060638)2.65605717
74cardiac muscle hypertrophy (GO:0003300)2.65388828
75cell-substrate adherens junction assembly (GO:0007045)2.65217072
76focal adhesion assembly (GO:0048041)2.65217072
77negative regulation of defense response to virus (GO:0050687)2.64977734
78sarcomere organization (GO:0045214)2.64071632
79heterochromatin organization (GO:0070828)2.62799704
80complement activation, alternative pathway (GO:0006957)2.62632057
81histone H3-K9 demethylation (GO:0033169)2.61975120
82kynurenine metabolic process (GO:0070189)2.61446307
83regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.59305313
84bile acid biosynthetic process (GO:0006699)2.58344955
85ADP metabolic process (GO:0046031)2.58226078
86midgut development (GO:0007494)2.57824369
87ribosome assembly (GO:0042255)2.57546299
88chondrocyte development (GO:0002063)2.57002242
89regulation of phospholipase A2 activity (GO:0032429)2.56852810
90erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.56565144
91L-phenylalanine metabolic process (GO:0006558)2.56565144
92positive regulation of fatty acid oxidation (GO:0046321)2.56436098
93fibroblast migration (GO:0010761)2.56391416
94cellular response to arsenic-containing substance (GO:0071243)2.55740827
95N-terminal protein amino acid acetylation (GO:0006474)2.55205156
96aromatic amino acid family catabolic process (GO:0009074)2.55020492
97positive regulation of histone deacetylation (GO:0031065)2.55010338
98positive regulation of lipid catabolic process (GO:0050996)2.54846437
99regulation of protein activation cascade (GO:2000257)2.54580398
100dicarboxylic acid biosynthetic process (GO:0043650)2.53256981
101negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.52392216
102membrane budding (GO:0006900)2.52120180
103mRNA stabilization (GO:0048255)2.52044170
104RNA stabilization (GO:0043489)2.52044170
105relaxation of smooth muscle (GO:0044557)2.50854236
106adherens junction assembly (GO:0034333)2.49903776
107iron ion import (GO:0097286)2.49000481
108peptidyl-glutamic acid carboxylation (GO:0017187)2.48764681
109protein carboxylation (GO:0018214)2.48764681
110apoptotic cell clearance (GO:0043277)2.48422494
111cellular response to growth hormone stimulus (GO:0071378)2.46508528
112corticosteroid receptor signaling pathway (GO:0031958)2.46383276
113protein localization to endosome (GO:0036010)2.46245209
114COPI coating of Golgi vesicle (GO:0048205)2.45962020
115Golgi transport vesicle coating (GO:0048200)2.45962020
116striated muscle hypertrophy (GO:0014897)2.45422008
117protein-lipid complex assembly (GO:0065005)2.44852445
118positive regulation of p38MAPK cascade (GO:1900745)2.44730477
119NLS-bearing protein import into nucleus (GO:0006607)2.43848818
120embryonic retina morphogenesis in camera-type eye (GO:0060059)2.43663962
121positive regulation of SMAD protein import into nucleus (GO:0060391)2.43548533
122pore complex assembly (GO:0046931)2.43473851
123regulation of SMAD protein import into nucleus (GO:0060390)2.43211446
124regulation of complement activation (GO:0030449)2.40915836
125epoxygenase P450 pathway (GO:0019373)2.40627867
126endoplasmic reticulum organization (GO:0007029)2.40570329
127cellular response to lithium ion (GO:0071285)2.40450195
128negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)2.40320346
129UDP-N-acetylglucosamine metabolic process (GO:0006047)2.40111010
130sulfur amino acid catabolic process (GO:0000098)2.39749456
131epithelial cell differentiation involved in prostate gland development (GO:0060742)2.39503752
132regulation of cardiac muscle cell apoptotic process (GO:0010665)2.39494204
133Leydig cell differentiation (GO:0033327)2.37256427
134plasma lipoprotein particle clearance (GO:0034381)2.36836787
135lipoprotein metabolic process (GO:0042157)2.36478778
136retina vasculature morphogenesis in camera-type eye (GO:0061299)2.35516286
137regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.35496144
138negative regulation of JNK cascade (GO:0046329)2.35285249
139fatty acid transmembrane transport (GO:1902001)2.35139820
140peptidyl-threonine modification (GO:0018210)2.35095491
141low-density lipoprotein particle clearance (GO:0034383)2.34908076
142plasma lipoprotein particle assembly (GO:0034377)2.34544467
143embryonic process involved in female pregnancy (GO:0060136)2.33968757
144cortical actin cytoskeleton organization (GO:0030866)2.33464062
145nitrogen cycle metabolic process (GO:0071941)2.33395465
146negative regulation of fatty acid transport (GO:2000192)2.32357364
147tryptophan metabolic process (GO:0006568)2.32215101
148regulation of RNA export from nucleus (GO:0046831)2.30782458
149regulation of skeletal muscle fiber development (GO:0048742)2.30533170
150energy homeostasis (GO:0097009)2.30404221
151regulation of fibroblast apoptotic process (GO:2000269)2.30183846
152regulation of DNA-templated transcription, initiation (GO:2000142)2.30126287
153regulation of fibrinolysis (GO:0051917)2.28908509
154negative regulation of lipid transport (GO:0032369)2.28765500
155negative regulation of response to reactive oxygen species (GO:1901032)2.28757079
156cellular polysaccharide metabolic process (GO:0044264)2.28208958
157cardiac muscle hypertrophy in response to stress (GO:0014898)2.28171041
158muscle hypertrophy in response to stress (GO:0003299)2.28171041
159cardiac muscle adaptation (GO:0014887)2.28171041
160positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.27090922
161regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.26839213
162positive regulation of glycolytic process (GO:0045821)2.26784421
1632-oxoglutarate metabolic process (GO:0006103)2.26745783
164negative regulation of smooth muscle cell migration (GO:0014912)2.26564624
165positive regulation of myoblast differentiation (GO:0045663)2.26293236
166negative regulation of sterol transport (GO:0032372)2.26290889
167negative regulation of cholesterol transport (GO:0032375)2.26290889
168glyoxylate metabolic process (GO:0046487)2.26116970
169carnitine shuttle (GO:0006853)2.26085256
170negative regulation of smooth muscle cell proliferation (GO:0048662)2.25949901
171histone lysine demethylation (GO:0070076)2.25734094
172tryptophan catabolic process (GO:0006569)2.25721728
173indole-containing compound catabolic process (GO:0042436)2.25721728
174indolalkylamine catabolic process (GO:0046218)2.25721728
175cell migration involved in sprouting angiogenesis (GO:0002042)2.25162816
176urate metabolic process (GO:0046415)2.25126010
177regulation of sister chromatid cohesion (GO:0007063)2.25063108
178regulation of cholesterol storage (GO:0010885)2.24776430
179regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.23459446
180positive regulation of glycogen biosynthetic process (GO:0045725)2.22216851
181negative regulation of heart growth (GO:0061117)2.21614641
182negative regulation of cardiac muscle tissue growth (GO:0055022)2.21614641
183macroautophagy (GO:0016236)2.21428046
184regulation of triglyceride catabolic process (GO:0010896)2.20928516
185valine metabolic process (GO:0006573)2.20891957
186polarized epithelial cell differentiation (GO:0030859)2.19419327
187reverse cholesterol transport (GO:0043691)2.18811082
188negative regulation of fatty acid metabolic process (GO:0045922)2.18243007
189bile acid metabolic process (GO:0008206)2.17533951
190histone H3-K36 demethylation (GO:0070544)2.16910003

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.65645192
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.27508419
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.12131194
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.26205616
5CLOCK_20551151_ChIP-Seq_293T_Human3.20459094
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.19395745
7RXR_22158963_ChIP-Seq_LIVER_Mouse3.17257726
8IGF1R_20145208_ChIP-Seq_DFB_Human3.12020788
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.99980789
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.79354600
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.76762550
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.69366538
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.61741517
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.55188358
15E2F7_22180533_ChIP-Seq_HELA_Human2.26861895
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.18025019
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.17121838
18FOXO3_23340844_ChIP-Seq_DLD1_Human2.12590891
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.02197812
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.98147485
21ESR1_21235772_ChIP-Seq_MCF-7_Human1.93792403
22GATA1_22025678_ChIP-Seq_K562_Human1.91460481
23TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.81980286
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.77790442
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77193231
26GBX2_23144817_ChIP-Seq_PC3_Human1.76627338
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.75736453
28EGR1_23403033_ChIP-Seq_LIVER_Mouse1.75042362
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73009255
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69859030
31SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.66930326
32* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.65221756
33KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.62868240
34AR_21909140_ChIP-Seq_LNCAP_Human1.58293494
35FOXA2_19822575_ChIP-Seq_HepG2_Human1.58123035
36PPAR_26484153_Chip-Seq_NCI-H1993_Human1.56840150
37AR_21572438_ChIP-Seq_LNCaP_Human1.55960139
38STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.53539800
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53239405
40AHR_22903824_ChIP-Seq_MCF-7_Human1.52723692
41MYC_22102868_ChIP-Seq_BL_Human1.50946269
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.50750881
43CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.50482951
44RXR_22108803_ChIP-Seq_LS180_Human1.48828495
45SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.47176683
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46886316
47ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.46783015
48BRD4_25478319_ChIP-Seq_HGPS_Human1.46234390
49TCF7_22412390_ChIP-Seq_EML_Mouse1.45758614
50TP63_17297297_ChIP-ChIP_HaCaT_Human1.45537689
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.44626259
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.44280113
53NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42867646
54FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.41787226
55TRIM28_21343339_ChIP-Seq_HEK293_Human1.41311233
56SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40301693
57DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.40008350
58CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.38906003
59WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38448399
60ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.37369372
61FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.36812521
62SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.36471261
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.36422120
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35871514
65VDR_24787735_ChIP-Seq_THP-1_Human1.35180633
66SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.33080311
67FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.31998853
68SOX2_27498859_Chip-Seq_STOMACH_Mouse1.31573072
69HIF1A_21447827_ChIP-Seq_MCF-7_Human1.31118211
70SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.30987534
71SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.30987534
72RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30656366
73* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.30163370
74ZNF263_19887448_ChIP-Seq_K562_Human1.28463305
75FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.26804833
76RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25526350
77FUS_26573619_Chip-Seq_HEK293_Human1.25203448
78STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.24492777
79ESR1_20079471_ChIP-ChIP_T-47D_Human1.24381524
80P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22105258
81YAP1_20516196_ChIP-Seq_MESCs_Mouse1.21481144
82KDM2B_26808549_Chip-Seq_DND41_Human1.21122434
83TP53_16413492_ChIP-PET_HCT116_Human1.20893951
84PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.20893159
85BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19929601
86TP53_18474530_ChIP-ChIP_U2OS_Human1.18692368
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18319431
88RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.18087164
89WT1_19549856_ChIP-ChIP_CCG9911_Human1.17787442
90* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16313747
91KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15804794
92ER_23166858_ChIP-Seq_MCF-7_Human1.14515869
93* IRF8_27001747_Chip-Seq_BMDM_Mouse1.14004871
94ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12949797
95NOTCH1_21737748_ChIP-Seq_TLL_Human1.12461654
96TCF4_18268006_ChIP-ChIP_LS174T_Human1.12458417
97FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12369722
98TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.12323499
99GATA6_25053715_ChIP-Seq_YYC3_Human1.12212306
100* CJUN_26792858_Chip-Seq_BT549_Human1.11460307
101EP300_21415370_ChIP-Seq_HL-1_Mouse1.10375951
102FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.10132976
103TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.09531243
104KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09486904
105* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09218907
106NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08866702
107NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08866702
108NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06706548
109TBX20_22328084_ChIP-Seq_HEART_Mouse1.05513285
110TBX20_22080862_ChIP-Seq_HEART_Mouse1.05513285
111TFEB_21752829_ChIP-Seq_HELA_Human1.05260346
112TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05224285
113MYB_21317192_ChIP-Seq_ERMYB_Mouse1.05112003
114PKCTHETA_26484144_Chip-Seq_BREAST_Human1.04854892
115IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04694349
116SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04287447
117TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03529326
118FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03458625
119MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02228417
120CHD1_26751641_Chip-Seq_LNCaP_Human1.01935945
121KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01895632
122HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01507068
123KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.01492083
124KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.01492083
125KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.01492083
126NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.00798596
127RUNX_20019798_ChIP-Seq_JUKART_Human1.00635118
128KDM2B_26808549_Chip-Seq_JURKAT_Human0.99841401
129SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99424838
130ISL1_27105846_Chip-Seq_CPCs_Mouse0.98886766
131FOXA1_25552417_ChIP-Seq_VCAP_Human0.98139145
132SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98004431
133ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97868903
134SMAD4_21799915_ChIP-Seq_A2780_Human0.97291414
135TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96266646
136POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96266646
137PIAS1_25552417_ChIP-Seq_VCAP_Human0.95965891
138* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95894023
139ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93392140
140P300_19829295_ChIP-Seq_ESCs_Human0.92501356
141* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91197104
142EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.90177637
143OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90081796
144MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.89832204
145GF1B_26923725_Chip-Seq_HPCs_Mouse0.88980064
146* TP63_23658742_ChIP-Seq_EP156T_Human0.88605463

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.76685043
2MP0008004_abnormal_stomach_pH3.57299409
3MP0010234_abnormal_vibrissa_follicle3.35905336
4MP0005360_urolithiasis3.33114229
5MP0002139_abnormal_hepatobiliary_system3.31851942
6MP0003300_gastrointestinal_ulcer3.17831575
7MP0004084_abnormal_cardiac_muscle3.12644061
8MP0000749_muscle_degeneration2.84052080
9MP0006054_spinal_hemorrhage2.79525322
10MP0009697_abnormal_copulation2.72824186
11MP0003252_abnormal_bile_duct2.66947940
12MP0005365_abnormal_bile_salt2.58677141
13MP0000569_abnormal_digit_pigmentation2.46737180
14MP0010352_gastrointestinal_tract_polyps2.34295155
15MP0003315_abnormal_perineum_morphology2.33553330
16MP0004036_abnormal_muscle_relaxation2.28898322
17MP0005085_abnormal_gallbladder_physiolo2.26773885
18MP0005076_abnormal_cell_differentiation2.05872080
19MP0004233_abnormal_muscle_weight2.05271298
20MP0005058_abnormal_lysosome_morphology1.95222637
21MP0008438_abnormal_cutaneous_collagen1.90724741
22MP0003221_abnormal_cardiomyocyte_apopto1.82021857
23MP0010368_abnormal_lymphatic_system1.80154419
24MP0003941_abnormal_skin_development1.78736534
25MP0002269_muscular_atrophy1.75677079
26MP0002877_abnormal_melanocyte_morpholog1.69333366
27MP0004087_abnormal_muscle_fiber1.64836063
28MP0008057_abnormal_DNA_replication1.63521820
29MP0009384_cardiac_valve_regurgitation1.63311415
30MP0004264_abnormal_extraembryonic_tissu1.62611960
31MP0005409_darkened_coat_color1.62477123
32MP0000747_muscle_weakness1.60649273
33MP0005330_cardiomyopathy1.56434307
34MP0001958_emphysema1.55114381
35MP0002127_abnormal_cardiovascular_syste1.49524684
36MP0002108_abnormal_muscle_morphology1.44000991
37MP0001188_hyperpigmentation1.43901023
38MP0000759_abnormal_skeletal_muscle1.43753676
39MP0002166_altered_tumor_susceptibility1.43654189
40MP0009053_abnormal_anal_canal1.42686661
41MP0003385_abnormal_body_wall1.42134897
42MP0003566_abnormal_cell_adhesion1.40881410
43MP0008875_abnormal_xenobiotic_pharmacok1.37603322
44MP0010329_abnormal_lipoprotein_level1.37571847
45MP0000733_abnormal_muscle_development1.37030900
46MP0004185_abnormal_adipocyte_glucose1.35593096
47MP0001666_abnormal_nutrient_absorption1.33284744
48MP0010678_abnormal_skin_adnexa1.33187498
49MP0003890_abnormal_embryonic-extraembry1.32744290
50MP0003567_abnormal_fetal_cardiomyocyte1.32602946
51MP0001849_ear_inflammation1.31673181
52MP0000609_abnormal_liver_physiology1.30181837
53MP0004130_abnormal_muscle_cell1.29450302
54MP0005275_abnormal_skin_tensile1.28935311
55MP0004484_altered_response_of1.27393748
56MP0002132_abnormal_respiratory_system1.26561744
57MP0003115_abnormal_respiratory_system1.25255201
58MP0002254_reproductive_system_inflammat1.25057659
59MP0001915_intracranial_hemorrhage1.24885335
60MP0000751_myopathy1.22995307
61MP0010307_abnormal_tumor_latency1.21191859
62MP0003191_abnormal_cellular_cholesterol1.18864061
63MP0005620_abnormal_muscle_contractility1.18585439
64MP0006138_congestive_heart_failure1.16815166
65MP0000537_abnormal_urethra_morphology1.15899503
66MP0005248_abnormal_Harderian_gland1.15342074
67MP0003091_abnormal_cell_migration1.09985602
68MP0004272_abnormal_basement_membrane1.09610884
69MP0005408_hypopigmentation1.09348972
70MP0002998_abnormal_bone_remodeling1.07469384
71MP0001661_extended_life_span1.07426768
72MP0005332_abnormal_amino_acid1.06643658
73MP0002896_abnormal_bone_mineralization1.06326380
74MP0000767_abnormal_smooth_muscle1.05348221
75MP0003806_abnormal_nucleotide_metabolis1.04592972
76MP0005187_abnormal_penis_morphology1.04268508
77MP0002009_preneoplasia1.02596240
78MP0005647_abnormal_sex_gland1.00817810
79MP0004215_abnormal_myocardial_fiber1.00748530
80MP0001299_abnormal_eye_distance/1.00612597
81MP0005023_abnormal_wound_healing1.00158713
82MP0003303_peritoneal_inflammation0.99147717
83MP0005385_cardiovascular_system_phenoty0.98215229
84MP0001544_abnormal_cardiovascular_syste0.98215229
85MP0003279_aneurysm0.98122627
86MP0002086_abnormal_extraembryonic_tissu0.97773009
87MP0004197_abnormal_fetal_growth/weight/0.97179795
88MP0005666_abnormal_adipose_tissue0.97093377
89MP0003937_abnormal_limbs/digits/tail_de0.95944746
90MP0000428_abnormal_craniofacial_morphol0.95647509
91MP0002928_abnormal_bile_duct0.95093397
92MP0003868_abnormal_feces_composition0.94913485
93MP0010630_abnormal_cardiac_muscle0.94393879
94MP0002233_abnormal_nose_morphology0.94121363
95MP0003453_abnormal_keratinocyte_physiol0.93659580
96MP0000598_abnormal_liver_morphology0.92174790
97MP0008961_abnormal_basal_metabolism0.92120076
98MP0009278_abnormal_bone_marrow0.91063290
99MP0009672_abnormal_birth_weight0.89636075
100MP0002796_impaired_skin_barrier0.89450611
101MP0002972_abnormal_cardiac_muscle0.89239166
102MP0002088_abnormal_embryonic_growth/wei0.89134335
103MP0005451_abnormal_body_composition0.87679650
104MP0004782_abnormal_surfactant_physiolog0.87575317
105MP0002006_tumorigenesis0.86959224
106MP0002138_abnormal_hepatobiliary_system0.86618838
107MP0003984_embryonic_growth_retardation0.86364775
108MP0002128_abnormal_blood_circulation0.85284354
109MP0009250_abnormal_appendicular_skeleto0.85040189
110MP0005621_abnormal_cell_physiology0.84871926
111MP0002092_abnormal_eye_morphology0.84571717
112MP0002925_abnormal_cardiovascular_devel0.83472789
113MP0003935_abnormal_craniofacial_develop0.83001365
114MP0002160_abnormal_reproductive_system0.81731852
115MP0002118_abnormal_lipid_homeostasis0.81572901
116MP0000465_gastrointestinal_hemorrhage0.81506178
117MP0000627_abnormal_mammary_gland0.80223348
118MP0002084_abnormal_developmental_patter0.79614416
119MP0004947_skin_inflammation0.79481130
120MP0009115_abnormal_fat_cell0.79254639
121MP0000762_abnormal_tongue_morphology0.79218929
122MP0005220_abnormal_exocrine_pancreas0.78491894
123MP0002971_abnormal_brown_adipose0.78378876
124MP0004808_abnormal_hematopoietic_stem0.77013531
125MP0009840_abnormal_foam_cell0.76678943
126MP0005380_embryogenesis_phenotype0.76398379
127MP0001672_abnormal_embryogenesis/_devel0.76398379
128MP0005503_abnormal_tendon_morphology0.76237158
129MP0001879_abnormal_lymphatic_vessel0.76193232
130MP0005394_taste/olfaction_phenotype0.75786589
131MP0005499_abnormal_olfactory_system0.75786589
132MP0009703_decreased_birth_body0.75772103
133MP0000427_abnormal_hair_cycle0.75117682
134MP0003950_abnormal_plasma_membrane0.74695148
135MP0008007_abnormal_cellular_replicative0.74592029
136MP0002168_other_aberrant_phenotype0.74438406
137MP0000377_abnormal_hair_follicle0.74392593
138MP0005369_muscle_phenotype0.73596821
139MP0009780_abnormal_chondrocyte_physiolo0.73515060
140MP0003077_abnormal_cell_cycle0.73339379
141MP0002133_abnormal_respiratory_system0.72023983
142MP0005388_respiratory_system_phenotype0.72023983
143MP0003943_abnormal_hepatobiliary_system0.71770389
144MP0002115_abnormal_skeleton_extremities0.71200539
145MP0000371_diluted_coat_color0.71015683
146MP0003755_abnormal_palate_morphology0.71005977
147MP0005319_abnormal_enzyme/_coenzyme0.69854442
148MP0000604_amyloidosis0.69599833
149MP0000432_abnormal_head_morphology0.69314849
150MP0000266_abnormal_heart_morphology0.69096188
151MP0003436_decreased_susceptibility_to0.69042061
152MP0000462_abnormal_digestive_system0.68538091
153MP0002282_abnormal_trachea_morphology0.68078779
154MP0000383_abnormal_hair_follicle0.68033981
155MP0001730_embryonic_growth_arrest0.67932461
156MP0003828_pulmonary_edema0.67445381

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the columella (HP:0009929)4.48668090
2Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)4.21733540
3Hyporeflexia of lower limbs (HP:0002600)3.86320935
4Centrally nucleated skeletal muscle fibers (HP:0003687)3.75120566
5Resting tremor (HP:0002322)3.74315459
6Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.71937240
7Rimmed vacuoles (HP:0003805)3.54442721
8Exercise-induced muscle cramps (HP:0003710)3.50222534
9Deep venous thrombosis (HP:0002625)3.47035748
10Spinal cord lesions (HP:0100561)3.42118172
11Syringomyelia (HP:0003396)3.42118172
12Abnormality of the shoulder girdle musculature (HP:0001435)3.39865950
13Scapular winging (HP:0003691)3.34418588
14Exercise-induced myalgia (HP:0003738)3.26193142
15Spinal rigidity (HP:0003306)3.21844462
16Abnormality of the frontal sinuses (HP:0002687)3.13522744
17EMG: myopathic abnormalities (HP:0003458)3.07506234
18Thoracic kyphosis (HP:0002942)3.05827074
19Urinary urgency (HP:0000012)3.05149836
20Reduced antithrombin III activity (HP:0001976)3.02522180
21Subacute progressive viral hepatitis (HP:0006572)2.98326943
22Cerebral aneurysm (HP:0004944)2.95233261
23Intrahepatic cholestasis (HP:0001406)2.94727974
24Xanthomatosis (HP:0000991)2.80314424
25Aortic aneurysm (HP:0004942)2.78775729
26Turricephaly (HP:0000262)2.76861033
27Abnormality of the calf musculature (HP:0001430)2.76215621
28Increased variability in muscle fiber diameter (HP:0003557)2.75328853
29Hematochezia (HP:0002573)2.74614396
30Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.68075796
31Mitral valve prolapse (HP:0001634)2.61022471
32Abnormality of skeletal muscle fiber size (HP:0012084)2.60312044
33Myocardial infarction (HP:0001658)2.58659869
34Shallow orbits (HP:0000586)2.58319411
35Curly hair (HP:0002212)2.57623067
36Hypoalphalipoproteinemia (HP:0003233)2.55604113
37Muscle fiber inclusion bodies (HP:0100299)2.55581423
38Clumsiness (HP:0002312)2.55070423
39Abnormality of the lumbar spine (HP:0100712)2.53449639
40Papillary thyroid carcinoma (HP:0002895)2.53336794
41Hypoglycemic coma (HP:0001325)2.51440929
42Limb-girdle muscle atrophy (HP:0003797)2.51056878
43Protrusio acetabuli (HP:0003179)2.50776908
44Thoracolumbar scoliosis (HP:0002944)2.47813136
45Osteolytic defects of the hand bones (HP:0009699)2.42411273
46Osteolytic defects of the phalanges of the hand (HP:0009771)2.42411273
47Abnormality of glutamine family amino acid metabolism (HP:0010902)2.41847101
48Complement deficiency (HP:0004431)2.38594412
49Capillary hemangiomas (HP:0005306)2.38432143
50Macroorchidism (HP:0000053)2.38262872
51Pelvic girdle muscle weakness (HP:0003749)2.38205096
52Spastic diplegia (HP:0001264)2.38118430
53Abnormality of the intrinsic pathway (HP:0010989)2.35772533
54Proximal amyotrophy (HP:0007126)2.35563956
55Asymmetry of the thorax (HP:0001555)2.35477171
56Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.35198786
57Short 4th metacarpal (HP:0010044)2.35198786
58Neck muscle weakness (HP:0000467)2.33716214
59Aneurysm (HP:0002617)2.32864778
60Shoulder girdle muscle weakness (HP:0003547)2.32360033
61Lymphangioma (HP:0100764)2.32002753
62Abnormality of proline metabolism (HP:0010907)2.30944333
63Hydroxyprolinuria (HP:0003080)2.30944333
64Difficulty running (HP:0009046)2.29945352
65Renovascular hypertension (HP:0100817)2.29862104
66Hepatocellular carcinoma (HP:0001402)2.29235886
67Abnormality of the common coagulation pathway (HP:0010990)2.28902368
68Disinhibition (HP:0000734)2.26275426
69Persistence of primary teeth (HP:0006335)2.25247850
70Epidermoid cyst (HP:0200040)2.23211024
71Abnormality of the musculature of the pelvis (HP:0001469)2.21465858
72Abnormality of the hip-girdle musculature (HP:0001445)2.21465858
73Elfin facies (HP:0004428)2.17757112
74Hypolipoproteinemia (HP:0010981)2.17756266
75Calf muscle hypertrophy (HP:0008981)2.15761384
76Abnormality of monocarboxylic acid metabolism (HP:0010996)2.15571773
77Absent frontal sinuses (HP:0002688)2.15281659
78Frequent falls (HP:0002359)2.14786227
79Aortic dissection (HP:0002647)2.14381240
80Hyperacusis (HP:0010780)2.14007380
81High anterior hairline (HP:0009890)2.13072240
82Muscular dystrophy (HP:0003560)2.12425762
83Subaortic stenosis (HP:0001682)2.12371686
84Abnormality of the left ventricular outflow tract (HP:0011103)2.12371686
85Broad metatarsal (HP:0001783)2.11916420
86Spondylolisthesis (HP:0003302)2.11275417
87Aplasia cutis congenita (HP:0001057)2.10592289
88Enlarged penis (HP:0000040)2.08742684
89Abnormality of the thoracic spine (HP:0100711)2.08320619
90Arterial tortuosity (HP:0005116)2.08238404
91Back pain (HP:0003418)2.06834253
92Abnormality of the 4th metacarpal (HP:0010012)2.06138221
93Abnormality of the fingertips (HP:0001211)2.05176570
94Muscle fiber splitting (HP:0003555)2.04903769
95Termporal pattern (HP:0011008)2.04173277
96Insidious onset (HP:0003587)2.04173277
97Muscle hypertrophy of the lower extremities (HP:0008968)2.02270856
98Abnormality of the peritoneum (HP:0002585)2.01031309
99Dilatation of the ascending aorta (HP:0005111)2.00917059
100Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.00633945
101Vascular tortuosity (HP:0004948)2.00449217
102Bladder diverticulum (HP:0000015)2.00412787
103Hyperglycemia (HP:0003074)2.00218924
104Limb-girdle muscle weakness (HP:0003325)2.00201568
105Distal arthrogryposis (HP:0005684)1.99823324
106Thin bony cortex (HP:0002753)1.99373695
107Steppage gait (HP:0003376)1.97693518
108Malignant gastrointestinal tract tumors (HP:0006749)1.96962402
109Gastrointestinal carcinoma (HP:0002672)1.96962402
110Esophageal varix (HP:0002040)1.96538553
111Skin nodule (HP:0200036)1.94853375
112Facial hemangioma (HP:0000329)1.94357799
113Increased connective tissue (HP:0009025)1.94153648
114Hypobetalipoproteinemia (HP:0003563)1.93332866
115Ankyloglossia (HP:0010296)1.92001507
116Pseudobulbar signs (HP:0002200)1.91704477
117Abnormality of complement system (HP:0005339)1.91018464
118Abnormal hair whorl (HP:0010721)1.90852738
119Mitral stenosis (HP:0001718)1.90694672
120Renal duplication (HP:0000075)1.90412805
121Ulnar bowing (HP:0003031)1.89582503
122Papilledema (HP:0001085)1.89461887
123Bowel diverticulosis (HP:0005222)1.88092495
124Cortical dysplasia (HP:0002539)1.88018924
125Eosinophilia (HP:0001880)1.87283663
126Rectal prolapse (HP:0002035)1.86768496
127Transitional cell carcinoma of the bladder (HP:0006740)1.86122121
128Hypochromic microcytic anemia (HP:0004840)1.85107848
129Striae distensae (HP:0001065)1.84660205
130Long toe (HP:0010511)1.83845566
131Premature rupture of membranes (HP:0001788)1.82946367
132Peritonitis (HP:0002586)1.82862405
133Abnormality of aromatic amino acid family metabolism (HP:0004338)1.82651940
134Abnormality of the diencephalon (HP:0010662)1.82602768
135Overriding aorta (HP:0002623)1.80029827
136Deviation of the hallux (HP:0010051)1.79600156
137Exostoses (HP:0100777)1.79528817
138Heterotopia (HP:0002282)1.78008807
139Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.77901943
140Long eyelashes (HP:0000527)1.77157147
141Pulmonic stenosis (HP:0001642)1.76450373
142Tibial bowing (HP:0002982)1.76048927
143Camptodactyly of toe (HP:0001836)1.75105346
144Diaphragmatic weakness (HP:0009113)1.75059601
145Sudden death (HP:0001699)1.74748887
146Relative macrocephaly (HP:0004482)1.74714519
147Nemaline bodies (HP:0003798)1.74227358
148Bulbar palsy (HP:0001283)1.73614488
149Difficulty climbing stairs (HP:0003551)1.72466223
150Radial bowing (HP:0002986)1.72412344
151Focal segmental glomerulosclerosis (HP:0000097)1.72079493
152Hallux valgus (HP:0001822)1.71881999
153Ankle contracture (HP:0006466)1.70201055
154Abnormality of oral frenula (HP:0000190)1.69891233
155Bladder carcinoma (HP:0002862)1.68959973
156Bladder neoplasm (HP:0009725)1.68959973
157Biliary tract neoplasm (HP:0100574)1.68741641
158Sensory axonal neuropathy (HP:0003390)1.68107555
159Postural instability (HP:0002172)1.67730429
160Knee flexion contracture (HP:0006380)1.66717199
161Overgrowth (HP:0001548)1.66648216
162Hypoglycemic seizures (HP:0002173)1.66530389
163Tetraparesis (HP:0002273)1.66309043
164Narrow palate (HP:0000189)1.66173215
165Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.65328413
166Right ventricular cardiomyopathy (HP:0011663)1.64558248
167Colitis (HP:0002583)1.64397380
168Popliteal pterygium (HP:0009756)1.64215887
169Abnormality of sulfur amino acid metabolism (HP:0004339)1.64128133
170Type 1 muscle fiber predominance (HP:0003803)1.64016695
171Hyperlipoproteinemia (HP:0010980)1.63474182
172Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.63274789
173Hypoplastic ischia (HP:0003175)1.62980019
174Ketosis (HP:0001946)1.62248337
175Blue sclerae (HP:0000592)1.61743473
176Mitral regurgitation (HP:0001653)1.61327807
177Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.60562834
178Cubitus valgus (HP:0002967)1.60124206
179Broad nasal tip (HP:0000455)1.59676432
180Myoglobinuria (HP:0002913)1.59266204
181Thyroid carcinoma (HP:0002890)1.59076551
182Self-mutilation (HP:0000742)1.57642595
183Recurrent corneal erosions (HP:0000495)1.57263444
184Foot dorsiflexor weakness (HP:0009027)1.54601733
185Abnormality of the foot musculature (HP:0001436)1.53362819
186Protruding tongue (HP:0010808)1.51697144
187Apathy (HP:0000741)1.50871084
188Weak cry (HP:0001612)1.50264330

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK16.54189062
2LATS14.63152024
3OBSCN3.48018554
4PKN23.04691838
5TRIB32.82826630
6TTN2.53708812
7CDK122.46531518
8EEF2K2.43056949
9CAMK1D2.26458544
10FRK2.26075046
11SIK12.22457027
12PTK62.17805310
13SCYL22.13324316
14NEK22.11104139
15ERN12.03893188
16STK31.98064487
17EIF2AK31.95529447
18CDK61.91358727
19MAP2K71.89204210
20DYRK31.87873741
21MYLK1.80667498
22PDGFRA1.80218303
23RIPK11.77147690
24MAP3K21.71305711
25ICK1.67513152
26MAP3K101.67139435
27CAMK1G1.65497622
28AKT31.62796213
29STK101.59248997
30TAOK31.56059448
31MAP3K51.56020337
32FGFR31.44616545
33SGK21.42684907
34DMPK1.41847096
35MAP2K31.38637756
36BMX1.35517414
37MAP3K11.34905585
38SGK4941.31391584
39SGK2231.31391584
40FGFR41.31280862
41PDGFRB1.28971357
42MAP3K71.24840716
43FGFR21.24442224
44MOS1.24422861
45LATS21.23790573
46NLK1.23190374
47FLT31.22566828
48MTOR1.20718390
49MAP3K131.19894814
50CDK31.18120385
51PRPF4B1.16669852
52TGFBR21.15547737
53RET1.14923927
54LRRK21.14748347
55NUAK11.14172487
56KSR21.13877820
57MAP3K91.13725882
58ERBB41.11523643
59RPS6KB11.11304826
60MAPKAPK31.06537478
61NEK91.03786620
62MAP3K61.03155496
63DDR21.02362144
64FGFR11.01884487
65PTK20.99930403
66IRAK20.93825749
67EPHB10.93158779
68CSNK1G30.92411954
69SRPK10.92179477
70INSRR0.89933238
71MET0.88996768
72CSNK1G10.87018215
73MAP3K80.84650748
74CDC70.84251278
75PIK3CG0.84134810
76EPHA30.81032630
77JAK10.80759754
78CSNK1G20.80750976
79CDK40.80535675
80JAK30.80089182
81RPS6KB20.78710450
82MELK0.75173985
83ACVR1B0.74363325
84JAK20.73418694
85FGR0.72090561
86PRKAA20.69955918
87CSK0.69885123
88CDK90.69628195
89CLK10.67981186
90MST1R0.66640868
91ITK0.66588970
92MAP2K40.65727660
93YES10.65656281
94EGFR0.65414876
95STK380.62325074
96PAK40.61710191
97MAP4K10.60934817
98CHUK0.59972921
99PAK20.59093152
100EPHA20.58469817
101TRPM70.58418611
102GSK3A0.57705413
103KSR10.57433829
104TAOK10.56347678
105ERBB20.55199020
106CDC42BPA0.54628195
107PIK3CA0.53867246
108SGK30.52476743
109TYK20.52041352
110AKT20.52037088
111TTK0.51825315
112BCR0.50237039
113FER0.50205204
114MAPK120.49595949
115DYRK1B0.49260541
116ALK0.48354448
117BRD40.48323380
118PRKG20.47845966
119TBK10.47035299
120MAP3K30.46407260
121MKNK10.46322823
122BRSK20.45719675
123MAP3K140.45022915
124CSF1R0.43845848
125CSNK1D0.43242365
126MAPK110.42951959
127MARK30.42840719
128TGFBR10.42539115
129RPS6KA40.41968267
130ZAP700.40191919
131RAF10.39407169
132RPS6KA10.39246363
133HIPK20.39091836
134CDK140.38432910
135ERBB30.38041048
136RPS6KA50.37788070
137IGF1R0.37595245
138PAK30.37588601
139STK40.37319539
140INSR0.37192833
141ABL10.36618555
142CSNK1A1L0.36526308
143STK38L0.36039110
144PRKD10.35241351
145TIE10.35056400
146PRKAA10.32757271
147ATM0.31295033
148MAPK100.30951558
149RPS6KA20.30246279
150MARK20.28650917
151CAMK40.25791792
152PRKCQ0.25207022
153MAP3K40.25166852
154MKNK20.25024244
155BTK0.24978341

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.21479801
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.65970482
3Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.56633044
4Complement and coagulation cascades_Homo sapiens_hsa046102.08571053
5Fatty acid degradation_Homo sapiens_hsa000712.07094259
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.01752773
7Circadian rhythm_Homo sapiens_hsa047102.01408644
8Lysine degradation_Homo sapiens_hsa003102.01092290
9Arginine biosynthesis_Homo sapiens_hsa002201.96306977
10Gap junction_Homo sapiens_hsa045401.87515368
11Caffeine metabolism_Homo sapiens_hsa002321.83512631
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.80263048
13Selenocompound metabolism_Homo sapiens_hsa004501.74128456
14Thyroid cancer_Homo sapiens_hsa052161.71809465
15Tryptophan metabolism_Homo sapiens_hsa003801.62849046
16Fatty acid metabolism_Homo sapiens_hsa012121.59479004
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.53467488
18PPAR signaling pathway_Homo sapiens_hsa033201.50477833
19Adherens junction_Homo sapiens_hsa045201.45223075
20Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.44949003
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39431469
22Insulin resistance_Homo sapiens_hsa049311.38188970
23Staphylococcus aureus infection_Homo sapiens_hsa051501.33771865
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.31253315
25Apoptosis_Homo sapiens_hsa042101.30795504
26Dilated cardiomyopathy_Homo sapiens_hsa054141.28368624
27cGMP-PKG signaling pathway_Homo sapiens_hsa040221.27814990
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.26452718
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24655861
30Fatty acid biosynthesis_Homo sapiens_hsa000611.16690395
31mTOR signaling pathway_Homo sapiens_hsa041501.15271407
32Sphingolipid signaling pathway_Homo sapiens_hsa040711.14956820
33MicroRNAs in cancer_Homo sapiens_hsa052061.13450801
34mRNA surveillance pathway_Homo sapiens_hsa030151.13380564
35Proteoglycans in cancer_Homo sapiens_hsa052051.13348731
36Acute myeloid leukemia_Homo sapiens_hsa052211.12682994
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12574151
38Small cell lung cancer_Homo sapiens_hsa052221.12516760
39Bile secretion_Homo sapiens_hsa049761.12185962
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11801511
41Hedgehog signaling pathway_Homo sapiens_hsa043401.11402054
42Propanoate metabolism_Homo sapiens_hsa006401.09263756
43Focal adhesion_Homo sapiens_hsa045101.06016946
44Chronic myeloid leukemia_Homo sapiens_hsa052201.04567446
45Phagosome_Homo sapiens_hsa041451.02797145
46Estrogen signaling pathway_Homo sapiens_hsa049151.00324827
47Pancreatic cancer_Homo sapiens_hsa052120.99475887
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99349794
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.97711348
50Olfactory transduction_Homo sapiens_hsa047400.97671340
51Legionellosis_Homo sapiens_hsa051340.97299392
52Glioma_Homo sapiens_hsa052140.94223501
53Oxytocin signaling pathway_Homo sapiens_hsa049210.94011421
54Butanoate metabolism_Homo sapiens_hsa006500.94010420
55ErbB signaling pathway_Homo sapiens_hsa040120.93956738
56Melanoma_Homo sapiens_hsa052180.93379345
57Peroxisome_Homo sapiens_hsa041460.92849105
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92603561
59Renin secretion_Homo sapiens_hsa049240.91912973
60Adipocytokine signaling pathway_Homo sapiens_hsa049200.91356190
61Choline metabolism in cancer_Homo sapiens_hsa052310.91116880
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90072565
63Sulfur metabolism_Homo sapiens_hsa009200.89192814
64Sphingolipid metabolism_Homo sapiens_hsa006000.88679098
65Starch and sucrose metabolism_Homo sapiens_hsa005000.88535040
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88177615
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.87748572
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87415988
69Fat digestion and absorption_Homo sapiens_hsa049750.84350902
70ECM-receptor interaction_Homo sapiens_hsa045120.84144618
71Toxoplasmosis_Homo sapiens_hsa051450.83375346
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.81084915
73TGF-beta signaling pathway_Homo sapiens_hsa043500.81030848
74AMPK signaling pathway_Homo sapiens_hsa041520.80995724
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80806955
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80706221
77ABC transporters_Homo sapiens_hsa020100.79663412
78Alcoholism_Homo sapiens_hsa050340.78999567
79Type II diabetes mellitus_Homo sapiens_hsa049300.78986506
80Bladder cancer_Homo sapiens_hsa052190.77537652
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77466373
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77277946
83Osteoclast differentiation_Homo sapiens_hsa043800.76861207
84Other glycan degradation_Homo sapiens_hsa005110.76763799
852-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76004224
86FoxO signaling pathway_Homo sapiens_hsa040680.75705331
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75638999
88Prostate cancer_Homo sapiens_hsa052150.75229793
89T cell receptor signaling pathway_Homo sapiens_hsa046600.74588765
90Dorso-ventral axis formation_Homo sapiens_hsa043200.74143355
91Amoebiasis_Homo sapiens_hsa051460.73750839
92Hepatitis C_Homo sapiens_hsa051600.73037349
93TNF signaling pathway_Homo sapiens_hsa046680.72775653
94Colorectal cancer_Homo sapiens_hsa052100.72490571
95Tight junction_Homo sapiens_hsa045300.72201623
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71772201
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71123864
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.70417209
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68385763
100Regulation of autophagy_Homo sapiens_hsa041400.68021090
101Viral myocarditis_Homo sapiens_hsa054160.67550478
102Shigellosis_Homo sapiens_hsa051310.65408560
103Wnt signaling pathway_Homo sapiens_hsa043100.64937667
104Chemical carcinogenesis_Homo sapiens_hsa052040.63434178
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63219259
106Leishmaniasis_Homo sapiens_hsa051400.63004272
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62858407
108Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.62829613
109Platelet activation_Homo sapiens_hsa046110.62777768
110Endometrial cancer_Homo sapiens_hsa052130.62707381
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62550985
112Hepatitis B_Homo sapiens_hsa051610.62401872
113Melanogenesis_Homo sapiens_hsa049160.62061056
114Glucagon signaling pathway_Homo sapiens_hsa049220.61374474
115Hippo signaling pathway_Homo sapiens_hsa043900.60607808
116Prolactin signaling pathway_Homo sapiens_hsa049170.59714863
117B cell receptor signaling pathway_Homo sapiens_hsa046620.59334736
118Renal cell carcinoma_Homo sapiens_hsa052110.59090576
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58459967
120Histidine metabolism_Homo sapiens_hsa003400.58096491
121Inositol phosphate metabolism_Homo sapiens_hsa005620.57207909
122beta-Alanine metabolism_Homo sapiens_hsa004100.57115364
123Tuberculosis_Homo sapiens_hsa051520.56569800
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55849541
125MAPK signaling pathway_Homo sapiens_hsa040100.55645149
126Oocyte meiosis_Homo sapiens_hsa041140.55363872
127Insulin signaling pathway_Homo sapiens_hsa049100.54022075
128Biosynthesis of amino acids_Homo sapiens_hsa012300.52253809
129Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51839872
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51108240
131Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50758586
132Viral carcinogenesis_Homo sapiens_hsa052030.50567053
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49718998
134Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49485957
135Protein digestion and absorption_Homo sapiens_hsa049740.48948051
136Neurotrophin signaling pathway_Homo sapiens_hsa047220.48192151
137Non-small cell lung cancer_Homo sapiens_hsa052230.48030065
138Carbon metabolism_Homo sapiens_hsa012000.47285831
139Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47143528
140Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46368954
141Retinol metabolism_Homo sapiens_hsa008300.46228613
142Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45801481
143Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43295542
144Glycerolipid metabolism_Homo sapiens_hsa005610.43112879
145Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42956167
146Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42583370
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41533503
148Systemic lupus erythematosus_Homo sapiens_hsa053220.40858443
149Pathways in cancer_Homo sapiens_hsa052000.39578963

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