YWHABP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.75575247
2cytidine deamination (GO:0009972)5.48917815
3cytidine metabolic process (GO:0046087)5.48917815
4cytidine catabolic process (GO:0006216)5.48917815
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.09724491
6pyrimidine ribonucleoside catabolic process (GO:0046133)4.74195258
7Arp2/3 complex-mediated actin nucleation (GO:0034314)4.41601806
8cellular response to interleukin-15 (GO:0071350)4.39551594
9positive regulation of prostaglandin secretion (GO:0032308)3.99978755
10actin nucleation (GO:0045010)3.99268047
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.78214427
12ATP synthesis coupled proton transport (GO:0015986)3.76720175
13energy coupled proton transport, down electrochemical gradient (GO:0015985)3.76720175
14response to interleukin-15 (GO:0070672)3.74800475
15chaperone-mediated protein transport (GO:0072321)3.63800964
16regulation of B cell receptor signaling pathway (GO:0050855)3.60752547
17positive regulation of T cell mediated cytotoxicity (GO:0001916)3.48122985
18positive regulation of defense response to virus by host (GO:0002230)3.43047160
19positive T cell selection (GO:0043368)3.35357499
20regulation of prostaglandin secretion (GO:0032306)3.31878348
21establishment of protein localization to mitochondrial membrane (GO:0090151)3.31787719
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.30570751
23regulation of T cell mediated cytotoxicity (GO:0001914)3.29859985
24protein-cofactor linkage (GO:0018065)3.26370650
25positive regulation of interleukin-1 beta secretion (GO:0050718)3.21494278
26preassembly of GPI anchor in ER membrane (GO:0016254)3.19526929
27GPI anchor biosynthetic process (GO:0006506)3.18556194
28positive regulation of calcium-mediated signaling (GO:0050850)3.18298014
29tolerance induction (GO:0002507)3.15515809
30positive regulation of T cell mediated immunity (GO:0002711)3.15069332
31negative T cell selection (GO:0043383)3.14423859
32positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.12894933
33positive thymic T cell selection (GO:0045059)3.11800152
34mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.10931926
35regulation of germinal center formation (GO:0002634)3.10716775
36nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.09917029
37negative regulation of T cell apoptotic process (GO:0070233)3.06742266
38positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.06727332
39cell wall macromolecule metabolic process (GO:0044036)3.06184871
40exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.04896098
41respiratory electron transport chain (GO:0022904)3.03039483
42positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.02863511
43T cell costimulation (GO:0031295)3.02799597
44negative regulation of cell killing (GO:0031342)3.02686060
45negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.02686060
46regulation of leukocyte mediated cytotoxicity (GO:0001910)3.00616932
47regulation of interleukin-1 beta secretion (GO:0050706)3.00605933
48positive regulation of T cell cytokine production (GO:0002726)3.00567040
49positive regulation of interleukin-1 secretion (GO:0050716)3.00210425
50GPI anchor metabolic process (GO:0006505)2.99263994
51lymphocyte costimulation (GO:0031294)2.98883687
52regulation of chronic inflammatory response (GO:0002676)2.98337632
53regulation of T cell receptor signaling pathway (GO:0050856)2.98000019
54electron transport chain (GO:0022900)2.97368852
55protein neddylation (GO:0045116)2.94772475
56positive regulation of alpha-beta T cell proliferation (GO:0046641)2.93806290
57positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.92320545
58regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.91466528
59mast cell activation (GO:0045576)2.90813982
60positive regulation of interleukin-4 production (GO:0032753)2.89663440
61positive regulation of interleukin-8 secretion (GO:2000484)2.89163615
62T cell receptor signaling pathway (GO:0050852)2.88966604
63regulation of T cell tolerance induction (GO:0002664)2.87688649
64regulation of alpha-beta T cell proliferation (GO:0046640)2.86060799
65tumor necrosis factor-mediated signaling pathway (GO:0033209)2.84604976
66regulation of hypersensitivity (GO:0002883)2.83611402
67positive regulation of interleukin-17 production (GO:0032740)2.79697816
68T cell migration (GO:0072678)2.78718493
69iron-sulfur cluster assembly (GO:0016226)2.78346613
70metallo-sulfur cluster assembly (GO:0031163)2.78346613
71positive regulation of icosanoid secretion (GO:0032305)2.78113671
72proteasome assembly (GO:0043248)2.77770063
73regulation of interleukin-8 secretion (GO:2000482)2.76173994
74positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.75337270
75positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.75003347
76regulation of cell killing (GO:0031341)2.73465295
77negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.73436532
78positive regulation of fatty acid transport (GO:2000193)2.73201991
79regulation of T cell mediated immunity (GO:0002709)2.73195336
80pyrimidine nucleoside catabolic process (GO:0046135)2.73066576
81positive regulation of cell killing (GO:0031343)2.71981735
82RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.71576745
83negative regulation of T cell receptor signaling pathway (GO:0050860)2.69927697
84positive regulation of natural killer cell mediated immunity (GO:0002717)2.68265151
85positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.68236920
86positive regulation of heat generation (GO:0031652)2.67630286
87regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.67233639
88regulation of activation of Janus kinase activity (GO:0010533)2.67157180
89antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.65235387
90negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.64258699
91regulation of defense response to virus by host (GO:0050691)2.64253339
92positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.63621806
93positive regulation of lymphocyte mediated immunity (GO:0002708)2.63586332
94platelet dense granule organization (GO:0060155)2.62963381
95positive regulation of adaptive immune response (GO:0002821)2.62821573
96regulation of cellular amino acid metabolic process (GO:0006521)2.62408948
97positive regulation of interleukin-1 beta production (GO:0032731)2.61680714
98antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.61131805
99regulation of fever generation (GO:0031620)2.61109416
100negative regulation of heart rate (GO:0010459)2.60871269

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.25063723
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.64068905
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.62656416
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.46590059
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.17098900
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.13213969
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.11881123
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.06958248
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.95394888
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.82969469
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.75599282
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.65959346
13VDR_23849224_ChIP-Seq_CD4+_Human2.59334477
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.56276704
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.48986802
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.39347402
17VDR_22108803_ChIP-Seq_LS180_Human2.18592645
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.14572279
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.12961562
20MYB_26560356_Chip-Seq_TH2_Human2.10232708
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.99166053
22RUNX_20019798_ChIP-Seq_JUKART_Human1.99011488
23GATA3_26560356_Chip-Seq_TH2_Human1.98316822
24TAF15_26573619_Chip-Seq_HEK293_Human1.96606468
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.86297829
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.83687612
27FOXP3_21729870_ChIP-Seq_TREG_Human1.83463014
28STAT4_19710469_ChIP-ChIP_TH1__Mouse1.76683702
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.74988482
30ELK1_19687146_ChIP-ChIP_HELA_Human1.74548248
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.72987190
32ZNF274_21170338_ChIP-Seq_K562_Hela1.72043956
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.71846177
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62463249
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.59867774
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.58199231
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47759753
38GATA3_27048872_Chip-Seq_THYMUS_Human1.45714141
39IGF1R_20145208_ChIP-Seq_DFB_Human1.38243043
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37543691
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.35508995
42SPI1_23547873_ChIP-Seq_NB4_Human1.33119355
43MYC_18940864_ChIP-ChIP_HL60_Human1.32435493
44TP53_22573176_ChIP-Seq_HFKS_Human1.30978939
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30666593
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30618767
47MYB_26560356_Chip-Seq_TH1_Human1.30550793
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.30353693
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.25350353
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.24430875
51P300_19829295_ChIP-Seq_ESCs_Human1.23321803
52FOXH1_21741376_ChIP-Seq_EPCs_Human1.22138689
53SOX2_19829295_ChIP-Seq_ESCs_Human1.21059416
54NANOG_19829295_ChIP-Seq_ESCs_Human1.21059416
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20013039
56IRF8_27001747_Chip-Seq_BMDM_Mouse1.20008922
57TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.18928071
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17040685
59PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16902275
60CIITA_25753668_ChIP-Seq_RAJI_Human1.15681853
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.15265033
62FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15265033
63ER_23166858_ChIP-Seq_MCF-7_Human1.14040873
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13603420
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13016899
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12914412
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12672902
68FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12610059
69PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11506305
70EWS_26573619_Chip-Seq_HEK293_Human1.09385478
71MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.08774244
72AR_20517297_ChIP-Seq_VCAP_Human1.07213098
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.07090937
74PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06848039
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06485211
76EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06399807
77FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05788524
78EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03672014
79TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03229415
80HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02967627
81DCP1A_22483619_ChIP-Seq_HELA_Human1.02318405
82FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01664915
83CBP_20019798_ChIP-Seq_JUKART_Human1.01386911
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01386911
85GATA3_26560356_Chip-Seq_TH1_Human1.00952393
86RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00317727
87HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99739322
88FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.99377653
89PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.98949590
90ERG_20517297_ChIP-Seq_VCAP_Human0.95436878
91CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94430019
92GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.94360767
93CRX_20693478_ChIP-Seq_RETINA_Mouse0.93612298
94AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92626457
95TAF2_19829295_ChIP-Seq_ESCs_Human0.91174272
96SALL4_22934838_ChIP-ChIP_CD34+_Human0.90284840
97RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.89753469
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88689550
99ELK1_22589737_ChIP-Seq_MCF10A_Human0.88084685
100LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.87466451

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.30858250
2MP0001835_abnormal_antigen_presentation4.46589137
3MP0003724_increased_susceptibility_to3.73105826
4MP0002166_altered_tumor_susceptibility3.19008205
5MP0000685_abnormal_immune_system3.11477854
6MP0009785_altered_susceptibility_to3.08623946
7MP0005000_abnormal_immune_tolerance2.92124120
8MP0001800_abnormal_humoral_immune2.83655753
9MP0002006_tumorigenesis2.54386986
10MP0003763_abnormal_thymus_physiology2.48980277
11MP0002148_abnormal_hypersensitivity_rea2.47538765
12MP0002723_abnormal_immune_serum2.44617152
13MP0003436_decreased_susceptibility_to2.33373428
14MP0002452_abnormal_antigen_presenting2.29963589
15MP0001819_abnormal_immune_cell2.29120305
16MP0002420_abnormal_adaptive_immunity2.28375923
17MP0006082_CNS_inflammation2.23750404
18MP0001790_abnormal_immune_system2.21944637
19MP0005387_immune_system_phenotype2.21944637
20MP0003195_calcinosis1.99198213
21MP0009333_abnormal_splenocyte_physiolog1.99082982
22MP0006072_abnormal_retinal_apoptosis1.95639655
23MP0009764_decreased_sensitivity_to1.83908471
24MP0002398_abnormal_bone_marrow1.83597096
25MP0005025_abnormal_response_to1.83195001
26MP0000716_abnormal_immune_system1.82934472
27MP0002102_abnormal_ear_morphology1.81529961
28MP0002163_abnormal_gland_morphology1.71978124
29MP0002933_joint_inflammation1.71431817
30MP0002419_abnormal_innate_immunity1.69902194
31MP0002405_respiratory_system_inflammati1.68653234
32MP0000689_abnormal_spleen_morphology1.62205412
33MP0008875_abnormal_xenobiotic_pharmacok1.48698218
34MP0002722_abnormal_immune_system1.48369096
35MP0003866_abnormal_defecation1.46763745
36MP0002009_preneoplasia1.46462211
37MP0000703_abnormal_thymus_morphology1.44464515
38MP0001188_hyperpigmentation1.43932543
39MP0008872_abnormal_physiological_respon1.41229081
40MP0001845_abnormal_inflammatory_respons1.40497172
41MP0003806_abnormal_nucleotide_metabolis1.39812040
42MP0002429_abnormal_blood_cell1.39588477
43MP0004147_increased_porphyrin_level1.39487188
44MP0002277_abnormal_respiratory_mucosa1.36822360
45MP0010155_abnormal_intestine_physiology1.35301633
46MP0005075_abnormal_melanosome_morpholog1.29342517
47MP0001919_abnormal_reproductive_system1.25305564
48MP0001853_heart_inflammation1.22470477
49MP0003786_premature_aging1.19533221
50MP0000465_gastrointestinal_hemorrhage1.17580895
51MP0000372_irregular_coat_pigmentation1.15658638
52MP0001533_abnormal_skeleton_physiology1.13582868
53MP0005551_abnormal_eye_electrophysiolog1.13272876
54MP0005645_abnormal_hypothalamus_physiol1.10176739
55MP0002837_dystrophic_cardiac_calcinosis1.08798925
56MP0008469_abnormal_protein_level1.08602373
57MP0008877_abnormal_DNA_methylation1.07994631
58MP0002876_abnormal_thyroid_physiology1.06692937
59MP0001873_stomach_inflammation1.06512610
60MP0000858_altered_metastatic_potential1.06032523
61MP0005389_reproductive_system_phenotype1.05148525
62MP0001501_abnormal_sleep_pattern1.01114650
63MP0006036_abnormal_mitochondrial_physio0.99842942
64MP0004947_skin_inflammation0.99745825
65MP0002736_abnormal_nociception_after0.98346689
66MP0005253_abnormal_eye_physiology0.95403779
67MP0009763_increased_sensitivity_to0.91341956
68MP0005379_endocrine/exocrine_gland_phen0.90577771
69MP0003878_abnormal_ear_physiology0.89180411
70MP0005377_hearing/vestibular/ear_phenot0.89180411
71MP0003448_altered_tumor_morphology0.88220703
72MP0000516_abnormal_urinary_system0.88052783
73MP0005367_renal/urinary_system_phenotyp0.88052783
74MP0001905_abnormal_dopamine_level0.86954477
75MP0005084_abnormal_gallbladder_morpholo0.86825021
76MP0009046_muscle_twitch0.85938759
77MP0001661_extended_life_span0.85149446
78MP0001984_abnormal_olfaction0.84582245
79MP0001968_abnormal_touch/_nociception0.82484054
80MP0002272_abnormal_nervous_system0.80099378
81MP0006035_abnormal_mitochondrial_morpho0.78899709
82MP0001765_abnormal_ion_homeostasis0.78643860
83MP0005636_abnormal_mineral_homeostasis0.78194123
84MP0004142_abnormal_muscle_tone0.71007383
85MP0006292_abnormal_olfactory_placode0.67573899
86MP0003787_abnormal_imprinting0.66778704
87MP0002019_abnormal_tumor_incidence0.65747569
88MP0003646_muscle_fatigue0.65458382
89MP0001986_abnormal_taste_sensitivity0.64803868
90MP0001764_abnormal_homeostasis0.64155318
91MP0002234_abnormal_pharynx_morphology0.63908953
92MP0005166_decreased_susceptibility_to0.63780043
93MP0002095_abnormal_skin_pigmentation0.63666807
94MP0005646_abnormal_pituitary_gland0.62403421
95MP0009745_abnormal_behavioral_response0.59532365
96MP0004381_abnormal_hair_follicle0.58705794
97MP0005584_abnormal_enzyme/coenzyme_acti0.57543473
98MP0005360_urolithiasis0.55536331
99MP0002693_abnormal_pancreas_physiology0.55195414
100MP0005332_abnormal_amino_acid0.55004388

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)4.50268392
2Elevated erythrocyte sedimentation rate (HP:0003565)4.30635167
3Severe combined immunodeficiency (HP:0004430)4.04439775
4T lymphocytopenia (HP:0005403)3.95912971
5Mitochondrial inheritance (HP:0001427)3.83420773
6Abnormality of T cell number (HP:0011839)3.81785676
73-Methylglutaconic aciduria (HP:0003535)3.60896527
8Increased hepatocellular lipid droplets (HP:0006565)3.46992721
9Chronic mucocutaneous candidiasis (HP:0002728)3.39847877
10Recurrent cutaneous fungal infections (HP:0011370)3.39847877
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.37897141
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.37897141
13Recurrent bronchitis (HP:0002837)3.35796268
14Lipid accumulation in hepatocytes (HP:0006561)3.33810219
15Acute necrotizing encephalopathy (HP:0006965)3.31468115
16Increased CSF lactate (HP:0002490)3.25004007
17Abnormality of eosinophils (HP:0001879)3.23780497
18Hepatocellular necrosis (HP:0001404)3.23722522
19Abnormality of T cells (HP:0002843)3.18825150
20Thyroiditis (HP:0100646)3.18497637
21Increased intramyocellular lipid droplets (HP:0012240)3.09852360
22Hypoproteinemia (HP:0003075)3.05228058
23Combined immunodeficiency (HP:0005387)3.05052431
24Abnormal mitochondria in muscle tissue (HP:0008316)3.04867218
25Hemoptysis (HP:0002105)3.02883153
26Abnormality of the prostate (HP:0008775)2.99762706
27Exertional dyspnea (HP:0002875)2.91892784
28Myositis (HP:0100614)2.81646567
29Eosinophilia (HP:0001880)2.80813254
30Progressive macrocephaly (HP:0004481)2.78514194
31Hepatic necrosis (HP:0002605)2.73738131
32Renal Fanconi syndrome (HP:0001994)2.72740459
33Absent rod-and cone-mediated responses on ERG (HP:0007688)2.68098542
34Optic neuritis (HP:0100653)2.67441836
35Retrobulbar optic neuritis (HP:0100654)2.67441836
36Panhypogammaglobulinemia (HP:0003139)2.67079899
37Increased muscle lipid content (HP:0009058)2.66422725
38Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.65843304
39Acute encephalopathy (HP:0006846)2.62502234
40Recurrent fungal infections (HP:0002841)2.62332379
41Aplastic anemia (HP:0001915)2.56778384
42Renal cortical cysts (HP:0000803)2.55473817
43Increased IgM level (HP:0003496)2.53710235
44Pulmonary infiltrates (HP:0002113)2.51358821
45Abnormality of T cell physiology (HP:0011840)2.50699360
46Gastrointestinal infarctions (HP:0005244)2.50439369
47Cerebral edema (HP:0002181)2.50411279
48Leukocytosis (HP:0001974)2.46790665
49Vasculitis (HP:0002633)2.42982927
50Autoimmune hemolytic anemia (HP:0001890)2.42335865
51Abolished electroretinogram (ERG) (HP:0000550)2.42089122
52B lymphocytopenia (HP:0010976)2.41842233
53Tetany (HP:0001281)2.40328300
54Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.38893630
55Lactic acidosis (HP:0003128)2.38558563
56Attenuation of retinal blood vessels (HP:0007843)2.38209575
57Chronic diarrhea (HP:0002028)2.35686467
58Increased serum lactate (HP:0002151)2.32193496
59Optic disc pallor (HP:0000543)2.31819091
60Abnormal rod and cone electroretinograms (HP:0008323)2.31044964
61Congenital, generalized hypertrichosis (HP:0004540)2.30745642
62Abnormality of B cell number (HP:0010975)2.30507764
63Stomatitis (HP:0010280)2.30235796
64Meningitis (HP:0001287)2.29879060
65Abnormal delayed hypersensitivity skin test (HP:0002963)2.27994852
66Gangrene (HP:0100758)2.27884570
67Increased density of long bones (HP:0006392)2.25927820
68Abnormality of the pleura (HP:0002103)2.25794433
69Facial diplegia (HP:0001349)2.24051103
70Granulocytopenia (HP:0001913)2.23724276
71Constricted visual fields (HP:0001133)2.23288150
72Congenital stationary night blindness (HP:0007642)2.22940530
73Pancreatic cysts (HP:0001737)2.21977084
74Encephalitis (HP:0002383)2.19661379
75Decreased central vision (HP:0007663)2.16995175
76Bronchitis (HP:0012387)2.14580324
77Decreased electroretinogram (ERG) amplitude (HP:0000654)2.11782208
78Keratoconjunctivitis (HP:0001096)2.10877392
79Molar tooth sign on MRI (HP:0002419)2.10548566
80Abnormality of midbrain morphology (HP:0002418)2.10548566
81Premature loss of primary teeth (HP:0006323)2.06853265
82Dynein arm defect of respiratory motile cilia (HP:0012255)2.05382248
83Absent/shortened dynein arms (HP:0200106)2.05382248
84Orchitis (HP:0100796)2.04689003
85Pancytopenia (HP:0001876)2.02586162
86Cerebral palsy (HP:0100021)2.02200381
87Obstructive lung disease (HP:0006536)2.00883251
88Chronic obstructive pulmonary disease (HP:0006510)2.00883251
89True hermaphroditism (HP:0010459)1.99393747
90Chronic sinusitis (HP:0011109)1.95878618
91Skin rash (HP:0000988)1.95672012
92Pancreatitis (HP:0001733)1.90070110
93Abnormality of alanine metabolism (HP:0010916)1.87767013
94Hyperalaninemia (HP:0003348)1.87767013
95Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87767013
96Type II lissencephaly (HP:0007260)1.87744991
97Autoimmune thrombocytopenia (HP:0001973)1.85921650
98Ureteral stenosis (HP:0000071)1.85155531
99Pustule (HP:0200039)1.84878799
100Exercise intolerance (HP:0003546)1.83804198

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK33.79762792
2KDR3.64082287
3TXK3.62584466
4MAP3K123.34988963
5TESK22.84171267
6BCKDK2.67821492
7BMPR22.63961847
8GRK62.41215166
9MAP4K12.40778904
10CDK192.32929939
11VRK22.29531665
12INSRR2.20938408
13TLK12.05270921
14BLK1.76988968
15MAP3K141.68696842
16MAP4K21.68255148
17LIMK11.67739270
18FRK1.53258971
19IKBKB1.52688671
20BUB11.50036728
21ADRBK21.49987779
22TRIM281.49576615
23ZAK1.48903413
24IKBKE1.47241794
25NUAK11.45926780
26GRK11.42211814
27MYLK1.41056986
28SYK1.38055811
29NEK11.37988814
30EIF2AK31.37596749
31MST41.34363455
32MUSK1.27309048
33OXSR11.24463295
34ITK1.24232157
35TBK11.19307073
36KIT1.18878123
37JAK11.12217280
38ZAP701.09631099
39DAPK11.03466331
40MAPKAPK31.03050941
41JAK30.99089633
42LCK0.97593274
43CSF1R0.97312611
44WNK40.96627585
45VRK10.96112178
46TYK20.95281696
47FES0.94447718
48EIF2AK20.92498804
49BCR0.90354877
50LYN0.87216199
51MAP2K20.85590415
52MAP3K110.85252433
53PRKCQ0.84924871
54MAP2K70.84117730
55ERBB30.83840257
56GRK70.83561984
57PIM10.82555228
58TEC0.82189693
59BTK0.77040593
60MAPK130.76381403
61PIK3CG0.70665876
62CSNK1G30.66246733
63GRK50.64275985
64RPS6KA50.61833882
65WNK30.60768022
66CAMKK20.60669216
67MAP3K50.59647163
68CCNB10.59566580
69RIPK40.59538516
70TIE10.57993733
71MAP3K40.56722710
72CSNK1G20.55988933
73PLK20.55177885
74TSSK60.53636556
75MATK0.53002189
76EIF2AK10.53000875
77MAPK70.52910398
78SCYL20.52203227
79CSNK1A1L0.52127952
80CSK0.51071118
81CHUK0.50874190
82TESK10.50745631
83IGF1R0.50313765
84PLK40.47763112
85ADRBK10.47180082
86RPS6KA40.45020347
87EPHA30.42767932
88SRPK10.41299325
89DYRK20.40818357
90PHKG10.40073114
91PHKG20.40073114
92IRAK40.38631544
93HCK0.38482049
94CSNK1G10.37435890
95EGFR0.37277996
96OBSCN0.36088664
97ABL10.35689798
98PRKCE0.33904343
99MAPKAPK50.28954633
100FLT30.28881608

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.86651655
2Allograft rejection_Homo sapiens_hsa053303.61835277
3Asthma_Homo sapiens_hsa053103.52652030
4Autoimmune thyroid disease_Homo sapiens_hsa053203.46225076
5Proteasome_Homo sapiens_hsa030503.41069704
6Primary immunodeficiency_Homo sapiens_hsa053403.16461719
7Intestinal immune network for IgA production_Homo sapiens_hsa046723.15401645
8Type I diabetes mellitus_Homo sapiens_hsa049403.03893793
9Oxidative phosphorylation_Homo sapiens_hsa001903.01594967
10Antigen processing and presentation_Homo sapiens_hsa046122.54115173
11Parkinsons disease_Homo sapiens_hsa050122.50839803
12Rheumatoid arthritis_Homo sapiens_hsa053232.41835061
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.34561840
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.16539994
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.87193412
16Viral myocarditis_Homo sapiens_hsa054161.80555260
17RNA polymerase_Homo sapiens_hsa030201.79290922
18Phototransduction_Homo sapiens_hsa047441.73578813
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.71314470
20Protein export_Homo sapiens_hsa030601.71083926
21Alzheimers disease_Homo sapiens_hsa050101.65464130
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.57577640
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.52862522
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.51991477
25Hematopoietic cell lineage_Homo sapiens_hsa046401.49299003
26Leishmaniasis_Homo sapiens_hsa051401.47111830
27Huntingtons disease_Homo sapiens_hsa050161.46461364
28Ribosome_Homo sapiens_hsa030101.35246008
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.34346194
30Staphylococcus aureus infection_Homo sapiens_hsa051501.32582580
31Cardiac muscle contraction_Homo sapiens_hsa042601.29924474
32RNA degradation_Homo sapiens_hsa030181.29292981
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.24668673
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15644799
35Caffeine metabolism_Homo sapiens_hsa002321.10682074
36T cell receptor signaling pathway_Homo sapiens_hsa046601.05664693
37Measles_Homo sapiens_hsa051620.98936736
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96206029
39Homologous recombination_Homo sapiens_hsa034400.96196306
40Collecting duct acid secretion_Homo sapiens_hsa049660.95763262
41Herpes simplex infection_Homo sapiens_hsa051680.94242530
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87446413
43Shigellosis_Homo sapiens_hsa051310.80873557
44Tuberculosis_Homo sapiens_hsa051520.78176311
45Salmonella infection_Homo sapiens_hsa051320.76192073
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75738235
47Nucleotide excision repair_Homo sapiens_hsa034200.74763506
48Nitrogen metabolism_Homo sapiens_hsa009100.74667521
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73619695
50Spliceosome_Homo sapiens_hsa030400.73007160
51Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72949120
52Systemic lupus erythematosus_Homo sapiens_hsa053220.71630840
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68756673
54SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68001996
55Epstein-Barr virus infection_Homo sapiens_hsa051690.65752149
56Legionellosis_Homo sapiens_hsa051340.65565356
57Basal transcription factors_Homo sapiens_hsa030220.62989256
58Toxoplasmosis_Homo sapiens_hsa051450.62287438
59Mismatch repair_Homo sapiens_hsa034300.54647247
60Pyrimidine metabolism_Homo sapiens_hsa002400.53011027
61Linoleic acid metabolism_Homo sapiens_hsa005910.52470309
62One carbon pool by folate_Homo sapiens_hsa006700.51565462
63Purine metabolism_Homo sapiens_hsa002300.50024910
64Malaria_Homo sapiens_hsa051440.48158624
65Regulation of autophagy_Homo sapiens_hsa041400.47940722
66Fanconi anemia pathway_Homo sapiens_hsa034600.47496021
67Phagosome_Homo sapiens_hsa041450.47084756
68Olfactory transduction_Homo sapiens_hsa047400.44797657
69DNA replication_Homo sapiens_hsa030300.43729662
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43415610
71Influenza A_Homo sapiens_hsa051640.41997792
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.41287514
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39254107
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38089459
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36924162
76Pertussis_Homo sapiens_hsa051330.36431417
77Propanoate metabolism_Homo sapiens_hsa006400.35486945
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34731201
79Taste transduction_Homo sapiens_hsa047420.34172330
80RNA transport_Homo sapiens_hsa030130.32777113
81Osteoclast differentiation_Homo sapiens_hsa043800.32368262
82Nicotine addiction_Homo sapiens_hsa050330.32351050
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31394341
84TNF signaling pathway_Homo sapiens_hsa046680.30583667
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.30475358
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28983591
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.28693140
88Tryptophan metabolism_Homo sapiens_hsa003800.28331696
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28294576
90Butanoate metabolism_Homo sapiens_hsa006500.26012756
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25380936
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.25003641
93Peroxisome_Homo sapiens_hsa041460.24871036
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.24609911
95Metabolic pathways_Homo sapiens_hsa011000.23108081
96Chemokine signaling pathway_Homo sapiens_hsa040620.22830304
97HTLV-I infection_Homo sapiens_hsa051660.22463656
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.22408925
99Morphine addiction_Homo sapiens_hsa050320.22349800
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14787420

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