YWHAE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of integrated proviral latency (GO:0075713)3.72221451
2synaptic vesicle maturation (GO:0016188)3.53923493
3cell migration in hindbrain (GO:0021535)3.50059292
4glucocorticoid receptor signaling pathway (GO:0042921)3.43456089
5peptidyl-arginine omega-N-methylation (GO:0035247)3.42139044
6synaptic vesicle docking involved in exocytosis (GO:0016081)3.41276545
7synaptic vesicle exocytosis (GO:0016079)3.40917064
8peptidyl-arginine methylation (GO:0018216)3.40410255
9peptidyl-arginine N-methylation (GO:0035246)3.40410255
10L-serine metabolic process (GO:0006563)3.39684342
11neuron cell-cell adhesion (GO:0007158)3.31795286
12layer formation in cerebral cortex (GO:0021819)3.26266476
13negative regulation of microtubule polymerization (GO:0031115)3.25686161
14glutamate secretion (GO:0014047)3.24422378
15regulation of short-term neuronal synaptic plasticity (GO:0048172)3.10587971
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.01940649
17histone arginine methylation (GO:0034969)3.01740768
18regulation of synaptic vesicle exocytosis (GO:2000300)2.97648907
19vocalization behavior (GO:0071625)2.96379003
20protein localization to synapse (GO:0035418)2.94135126
21locomotory exploration behavior (GO:0035641)2.93625457
22regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.93097893
23positive regulation of synapse maturation (GO:0090129)2.89062124
24negative regulation of dendrite morphogenesis (GO:0050774)2.87087791
25regulation of NFAT protein import into nucleus (GO:0051532)2.82817413
26axonal fasciculation (GO:0007413)2.77003065
27neuron recognition (GO:0008038)2.70857341
28establishment of viral latency (GO:0019043)2.70119664
29postsynaptic membrane organization (GO:0001941)2.69973531
30regulation of glutamate receptor signaling pathway (GO:1900449)2.67936631
31positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.65503534
32exploration behavior (GO:0035640)2.59645186
33regulation of synaptic vesicle transport (GO:1902803)2.53302559
34corticosteroid receptor signaling pathway (GO:0031958)2.53090763
35cullin deneddylation (GO:0010388)2.52537215
36chromatin remodeling at centromere (GO:0031055)2.49979961
37pre-miRNA processing (GO:0031054)2.49159460
38pyrimidine nucleobase catabolic process (GO:0006208)2.45449857
39innervation (GO:0060384)2.43108154
40dendrite morphogenesis (GO:0048813)2.42851849
41protein deneddylation (GO:0000338)2.41774539
42cerebral cortex radially oriented cell migration (GO:0021799)2.40930309
43regulation of long-term neuronal synaptic plasticity (GO:0048169)2.40329390
44protein localization to kinetochore (GO:0034501)2.39544121
45mitotic metaphase plate congression (GO:0007080)2.38637933
46CENP-A containing nucleosome assembly (GO:0034080)2.37766524
47chaperone-mediated protein transport (GO:0072321)2.37354737
48dendritic spine morphogenesis (GO:0060997)2.37174631
49neurotransmitter secretion (GO:0007269)2.36407230
50presynaptic membrane assembly (GO:0097105)2.36215831
51regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.36096858
52regulation of neuronal synaptic plasticity (GO:0048168)2.33981312
53regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.32179226
54cerebellum development (GO:0021549)2.31964654
55DNA damage response, detection of DNA damage (GO:0042769)2.30818170
56negative regulation of dendrite development (GO:2000171)2.30615668
57establishment of mitochondrion localization (GO:0051654)2.30175753
58cytoskeleton-dependent cytokinesis (GO:0061640)2.29610685
59regulation of synapse structural plasticity (GO:0051823)2.27833299
60nucleobase catabolic process (GO:0046113)2.27648185
61cerebellar granule cell differentiation (GO:0021707)2.24425561
62DNA strand elongation involved in DNA replication (GO:0006271)2.23997123
63apical protein localization (GO:0045176)2.23537267
64establishment of protein localization to mitochondrial membrane (GO:0090151)2.22751522
65presynaptic membrane organization (GO:0097090)2.22453515
66cellular potassium ion homeostasis (GO:0030007)2.22167646
67positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.21990488
68synaptic vesicle endocytosis (GO:0048488)2.21965712
69axon extension (GO:0048675)2.21942870
70* hippocampus development (GO:0021766)2.21251065
71central nervous system projection neuron axonogenesis (GO:0021952)2.21214796
72paraxial mesoderm development (GO:0048339)2.21096634
73protein localization to microtubule (GO:0035372)2.21025910
74establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.20518868
75mitochondrion transport along microtubule (GO:0047497)2.20518868
76protein-DNA complex disassembly (GO:0032986)2.19563601
77nucleosome disassembly (GO:0006337)2.19563601
78heterochromatin organization (GO:0070828)2.19401527
79dendrite development (GO:0016358)2.19347445
80mitotic cytokinesis (GO:0000281)2.18746141
81mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.17652808
82histone exchange (GO:0043486)2.16596027
83regulation of cAMP-dependent protein kinase activity (GO:2000479)2.16221970
84DNA unwinding involved in DNA replication (GO:0006268)2.15582400
85establishment of nucleus localization (GO:0040023)2.15167008
86DNA ligation (GO:0006266)2.14644099
87regulation of RNA export from nucleus (GO:0046831)2.14643903
88organelle transport along microtubule (GO:0072384)2.14498389
89regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.14250747
90positive regulation of synapse assembly (GO:0051965)2.13984545
91sister chromatid segregation (GO:0000819)2.13928988
92neurotransmitter-gated ion channel clustering (GO:0072578)2.13877077
93metaphase plate congression (GO:0051310)2.13053270
94DNA strand elongation (GO:0022616)2.12602816
95clathrin coat assembly (GO:0048268)2.11684975
96positive regulation of dendritic spine morphogenesis (GO:0061003)2.11136790
97nuclear pore organization (GO:0006999)2.10847837
98protein localization to chromosome, centromeric region (GO:0071459)2.10379966
99regulation of dendritic spine morphogenesis (GO:0061001)2.09720107
100ATP-dependent chromatin remodeling (GO:0043044)2.09309265
101notochord development (GO:0030903)2.08978316
102positive regulation of protein depolymerization (GO:1901881)2.08905155
103regulation of synapse maturation (GO:0090128)2.08616133
104auditory behavior (GO:0031223)2.08565603
105non-recombinational repair (GO:0000726)2.08525989
106double-strand break repair via nonhomologous end joining (GO:0006303)2.08525989
107vesicle transport along microtubule (GO:0047496)2.07666806
108body morphogenesis (GO:0010171)2.06171594
109synaptic transmission, glutamatergic (GO:0035249)2.05532916
110positive regulation of response to oxidative stress (GO:1902884)2.04356883
111positive regulation of cellular response to oxidative stress (GO:1900409)2.04356883
112mitotic sister chromatid cohesion (GO:0007064)2.04124918
113neuron-neuron synaptic transmission (GO:0007270)2.03978775
114DNA replication-independent nucleosome organization (GO:0034724)2.03784989
115DNA replication-independent nucleosome assembly (GO:0006336)2.03784989
116mitotic sister chromatid segregation (GO:0000070)2.03622254
117negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.03294829
118regulation of dendrite morphogenesis (GO:0048814)2.03050176
119positive regulation of protein complex disassembly (GO:0043243)2.02985006
120sodium ion export (GO:0071436)2.02503988
121neuron projection extension (GO:1990138)2.02403364
122spinal cord development (GO:0021510)2.02251855
123synapse assembly (GO:0007416)2.01723206
124DNA double-strand break processing (GO:0000729)2.01634914
125regulation of synaptic plasticity (GO:0048167)2.01577735
126cerebellar Purkinje cell layer development (GO:0021680)2.01082767
127positive regulation of peptidyl-threonine phosphorylation (GO:0010800)2.01046532
128serine family amino acid biosynthetic process (GO:0009070)2.00831660
129regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450911.99488202
130regulation of sister chromatid cohesion (GO:0007063)1.99321533
131mechanosensory behavior (GO:0007638)1.98747744
132protein depolymerization (GO:0051261)1.98643275
133cell communication by electrical coupling (GO:0010644)1.98510953
134regulation of glycogen (starch) synthase activity (GO:2000465)1.98325656
135peptidyl-cysteine modification (GO:0018198)1.98245454
136mitotic spindle organization (GO:0007052)1.97376819
137transmission of nerve impulse (GO:0019226)1.97339732
138mitotic chromosome condensation (GO:0007076)1.94807526
139retinal ganglion cell axon guidance (GO:0031290)1.91836352
140intraciliary transport (GO:0042073)1.90539977
141ectodermal placode formation (GO:0060788)1.88538903
142telomere maintenance via semi-conservative replication (GO:0032201)1.87871951
143DNA strand renaturation (GO:0000733)1.87711663
144regulation of respiratory gaseous exchange by neurological system process (GO:0002087)1.87567073
145negative regulation of mRNA processing (GO:0050686)1.87226227
146protein maturation by protein folding (GO:0022417)1.86113292
147kinetochore organization (GO:0051383)1.86058360
148DNA replication checkpoint (GO:0000076)1.85340877
149protein complex localization (GO:0031503)1.84164894
150dendritic spine organization (GO:0097061)1.84074501
151generation of neurons (GO:0048699)1.83859714
152mitochondrial ATP synthesis coupled proton transport (GO:0042776)1.82758387
153axon cargo transport (GO:0008088)1.82676751
154glutamine metabolic process (GO:0006541)1.82333649
155IMP biosynthetic process (GO:0006188)1.82309614
156regulation of DNA endoreduplication (GO:0032875)1.82190195
157asymmetric protein localization (GO:0008105)1.82153638
158cytoskeleton-dependent intracellular transport (GO:0030705)1.81472636
159lung-associated mesenchyme development (GO:0060484)1.81063868
160regulation of translational elongation (GO:0006448)1.81049311
161positive regulation of RNA splicing (GO:0033120)1.80838903

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse4.36595320
2E2F7_22180533_ChIP-Seq_HELA_Human3.39633204
3EZH2_22144423_ChIP-Seq_EOC_Human3.37797535
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.55772838
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.54053666
6GBX2_23144817_ChIP-Seq_PC3_Human2.31109338
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.30853126
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.23630567
9ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.20823209
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.18332637
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17344099
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.11923931
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.04816663
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.90275830
15SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.86523855
16* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.84277776
17CREB1_15753290_ChIP-ChIP_HEK293T_Human1.82050531
18EZH2_27304074_Chip-Seq_ESCs_Mouse1.80029472
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.78604202
20JARID2_20064375_ChIP-Seq_MESCs_Mouse1.70129068
21FUS_26573619_Chip-Seq_HEK293_Human1.67870650
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.66154561
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.65970841
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.62921419
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.62864626
26TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.60498711
27RARB_27405468_Chip-Seq_BRAIN_Mouse1.57279007
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.56042379
29POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.54113080
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.52823302
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52781112
32SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.52314095
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.52078715
34NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.50740185
35REST_21632747_ChIP-Seq_MESCs_Mouse1.49999967
36* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49531458
37RNF2_18974828_ChIP-Seq_MESCs_Mouse1.49484928
38EZH2_18974828_ChIP-Seq_MESCs_Mouse1.49484928
39AR_21572438_ChIP-Seq_LNCaP_Human1.48729047
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.46341259
41HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.46179891
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.44775914
43* XRN2_22483619_ChIP-Seq_HELA_Human1.44574432
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.42511670
45* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39809757
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.39333433
47ETS1_20019798_ChIP-Seq_JURKAT_Human1.37661189
48* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.37184742
49* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36816049
50* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.36692051
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.34600149
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34075279
53REST_18959480_ChIP-ChIP_MESCs_Mouse1.33911042
54JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.33808818
55* TTF2_22483619_ChIP-Seq_HELA_Human1.33125279
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.32606016
57* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32439826
58WT1_19549856_ChIP-ChIP_CCG9911_Human1.31803343
59EWS_26573619_Chip-Seq_HEK293_Human1.30829883
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30550294
61SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.30092312
62* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.28948114
63SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.28100270
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.28046038
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27728773
66NANOG_16153702_ChIP-ChIP_HESCs_Human1.26869657
67ELK1_19687146_ChIP-ChIP_HELA_Human1.26690896
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26279591
69SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.25829623
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.25781671
71RNF2_27304074_Chip-Seq_NSC_Mouse1.25630600
72SOX9_26525672_Chip-Seq_HEART_Mouse1.25394945
73MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24592983
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23147608
75SOX2_16153702_ChIP-ChIP_HESCs_Human1.20401139
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19699299
77ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.19609315
78ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19458362
79HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.18329178
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17997679
81PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17754213
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17720419
83* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17367213
84PKCTHETA_26484144_Chip-Seq_BREAST_Human1.16679778
85* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16322527
86SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16049659
87RING1B_27294783_Chip-Seq_NPCs_Mouse1.15823309
88P300_19829295_ChIP-Seq_ESCs_Human1.15535445
89POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15002238
90* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14267392
91CBX2_27304074_Chip-Seq_ESCs_Mouse1.13838720
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13774700
93* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12245653
94* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12136935
95BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11803302
96GATA1_26923725_Chip-Seq_HPCs_Mouse1.11765420
97* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11623232
98POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.11345775
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10825114
100SMAD4_21799915_ChIP-Seq_A2780_Human1.10098957
101KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10010813
102SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09994424
103ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09258453
104ZNF274_21170338_ChIP-Seq_K562_Hela1.09013836
105PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08690827
106NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08603926
107SMAD3_21741376_ChIP-Seq_EPCs_Human1.07722855
108CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.07138797
109PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06418037
110TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03409016
111SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.02852337
112RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02033311
113TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.01986763
114SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.01084057
115MYC_18940864_ChIP-ChIP_HL60_Human1.00761942
116NANOG_21062744_ChIP-ChIP_HESCs_Human1.00613263
117AR_21909140_ChIP-Seq_LNCAP_Human1.00553338
118IGF1R_20145208_ChIP-Seq_DFB_Human0.99803201
119GABP_19822575_ChIP-Seq_HepG2_Human0.99291801
120SOX17_20123909_ChIP-Seq_XEN_Mouse0.99196075
121DCP1A_22483619_ChIP-Seq_HELA_Human0.99116053
122* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99081694
123PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98874857
124PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98638493
125MYC_19079543_ChIP-ChIP_MESCs_Mouse0.97514906
126EZH2_27294783_Chip-Seq_ESCs_Mouse0.97269540
127* MYC_18555785_ChIP-Seq_MESCs_Mouse0.97018893
128SOX2_21211035_ChIP-Seq_LN229_Gbm0.96788060
129PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96743763
130ISL1_27105846_Chip-Seq_CPCs_Mouse0.96652355
131TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96155708
132MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.95814089
133* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95350277
134NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.94873808
135EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94826874
136NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.94591093
137RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94407715
138DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93767965
139* STAT3_23295773_ChIP-Seq_U87_Human0.93764815
140* REST_19997604_ChIP-ChIP_NEURONS_Mouse0.93702576
141TAF15_26573619_Chip-Seq_HEK293_Human0.93624520
142MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93539820
143* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93297457
144FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.92504231
145POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92080232
146FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.91622497
147MTF2_20144788_ChIP-Seq_MESCs_Mouse0.90163045

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.27885621
2MP0003122_maternal_imprinting2.95786347
3MP0003123_paternal_imprinting2.73212455
4MP0004270_analgesia2.62351097
5MP0003121_genomic_imprinting2.40331019
6MP0003880_abnormal_central_pattern2.38658015
7MP0003635_abnormal_synaptic_transmissio2.19566896
8MP0003787_abnormal_imprinting2.19415529
9MP0000778_abnormal_nervous_system2.18672710
10MP0000537_abnormal_urethra_morphology2.00712097
11MP0002063_abnormal_learning/memory/cond1.94404788
12MP0002734_abnormal_mechanical_nocicepti1.80036661
13MP0002653_abnormal_ependyma_morphology1.71509853
14MP0008877_abnormal_DNA_methylation1.68063024
15MP0001968_abnormal_touch/_nociception1.65995984
16MP0003693_abnormal_embryo_hatching1.59876077
17MP0002735_abnormal_chemical_nociception1.57427205
18MP0009745_abnormal_behavioral_response1.56466811
19MP0006292_abnormal_olfactory_placode1.55514936
20MP0004233_abnormal_muscle_weight1.51535603
21MP0001188_hyperpigmentation1.51481905
22MP0003890_abnormal_embryonic-extraembry1.49069536
23MP0002064_seizures1.48969328
24MP0010030_abnormal_orbit_morphology1.48608868
25MP0002572_abnormal_emotion/affect_behav1.48416486
26MP0002184_abnormal_innervation1.47519317
27MP0003119_abnormal_digestive_system1.47010125
28MP0009780_abnormal_chondrocyte_physiolo1.46991224
29MP0000566_synostosis1.46496914
30MP0008789_abnormal_olfactory_epithelium1.45336201
31MP0004858_abnormal_nervous_system1.45014034
32MP0003861_abnormal_nervous_system1.42181872
33* MP0004811_abnormal_neuron_physiology1.42003491
34MP0002751_abnormal_autonomic_nervous1.40565005
35MP0009053_abnormal_anal_canal1.39879158
36MP0003942_abnormal_urinary_system1.39702442
37MP0002736_abnormal_nociception_after1.37141332
38MP0005499_abnormal_olfactory_system1.36590408
39MP0005394_taste/olfaction_phenotype1.36590408
40MP0005367_renal/urinary_system_phenotyp1.35516759
41MP0000516_abnormal_urinary_system1.35516759
42MP0009046_muscle_twitch1.34629128
43MP0003385_abnormal_body_wall1.31302654
44MP0000534_abnormal_ureter_morphology1.30556030
45MP0005623_abnormal_meninges_morphology1.30139052
46MP0000955_abnormal_spinal_cord1.29151559
47MP0005423_abnormal_somatic_nervous1.28105896
48MP0001529_abnormal_vocalization1.26533291
49MP0002733_abnormal_thermal_nociception1.26475085
50MP0003136_yellow_coat_color1.25812679
51MP0002102_abnormal_ear_morphology1.24460751
52* MP0002152_abnormal_brain_morphology1.23959817
53MP0002697_abnormal_eye_size1.23336841
54MP0008058_abnormal_DNA_repair1.22602975
55MP0001346_abnormal_lacrimal_gland1.22438231
56MP0010094_abnormal_chromosome_stability1.19817607
57MP0003755_abnormal_palate_morphology1.19344300
58MP0002557_abnormal_social/conspecific_i1.17882553
59MP0002882_abnormal_neuron_morphology1.17297040
60MP0008932_abnormal_embryonic_tissue1.16581075
61MP0003283_abnormal_digestive_organ1.16304159
62MP0010234_abnormal_vibrissa_follicle1.15131037
63MP0000569_abnormal_digit_pigmentation1.13807169
64MP0002084_abnormal_developmental_patter1.13606376
65MP0001486_abnormal_startle_reflex1.13329892
66MP0000631_abnormal_neuroendocrine_gland1.12471616
67MP0004957_abnormal_blastocyst_morpholog1.11452665
68MP0003111_abnormal_nucleus_morphology1.11261294
69MP0003315_abnormal_perineum_morphology1.10805827
70MP0002272_abnormal_nervous_system1.10363584
71MP0006276_abnormal_autonomic_nervous1.09489528
72MP0002234_abnormal_pharynx_morphology1.08975750
73MP0009250_abnormal_appendicular_skeleto1.08909449
74MP0004885_abnormal_endolymph1.08705665
75MP0000049_abnormal_middle_ear1.08211179
76MP0003937_abnormal_limbs/digits/tail_de1.08190276
77MP0001730_embryonic_growth_arrest1.05521999
78MP0001286_abnormal_eye_development1.05379790
79MP0000647_abnormal_sebaceous_gland1.05291876
80MP0001299_abnormal_eye_distance/1.04948632
81MP0001970_abnormal_pain_threshold1.04934199
82MP0005187_abnormal_penis_morphology1.04099730
83MP0002067_abnormal_sensory_capabilities1.04045797
84MP0005386_behavior/neurological_phenoty1.03275778
85MP0004924_abnormal_behavior1.03275778
86MP0005076_abnormal_cell_differentiation1.02934800
87MP0002085_abnormal_embryonic_tissue1.02753571
88MP0005248_abnormal_Harderian_gland1.00913532
89MP0003077_abnormal_cell_cycle0.98449198
90MP0004197_abnormal_fetal_growth/weight/0.98238114
91MP0000579_abnormal_nail_morphology0.97969358
92MP0002233_abnormal_nose_morphology0.97720822
93MP0004133_heterotaxia0.97258767
94MP0002116_abnormal_craniofacial_bone0.96532809
95MP0003938_abnormal_ear_development0.96389890
96MP0009672_abnormal_birth_weight0.95584149
97MP0006072_abnormal_retinal_apoptosis0.95412624
98MP0009703_decreased_birth_body0.95248348
99* MP0002081_perinatal_lethality0.94812498
100MP0002090_abnormal_vision0.94801822
101MP0000350_abnormal_cell_proliferation0.94288783
102MP0001697_abnormal_embryo_size0.94067841
103MP0003115_abnormal_respiratory_system0.93829212
104MP0001984_abnormal_olfaction0.93750096
105MP0002909_abnormal_adrenal_gland0.92439007
106MP0001440_abnormal_grooming_behavior0.89934837
107MP0002638_abnormal_pupillary_reflex0.89491451
108MP0000428_abnormal_craniofacial_morphol0.88074920
109MP0003935_abnormal_craniofacial_develop0.87435420
110MP0002938_white_spotting0.85193826
111MP0002066_abnormal_motor_capabilities/c0.84492870
112MP0003941_abnormal_skin_development0.84302944
113MP0003567_abnormal_fetal_cardiomyocyte0.84234203
114MP0002822_catalepsy0.84075236
115MP0001672_abnormal_embryogenesis/_devel0.84004266
116MP0005380_embryogenesis_phenotype0.84004266
117MP0001293_anophthalmia0.83946079
118MP0008569_lethality_at_weaning0.83893972
119MP0001485_abnormal_pinna_reflex0.83351115
120MP0001177_atelectasis0.83239683
121MP0002092_abnormal_eye_morphology0.80352821
122MP0002752_abnormal_somatic_nervous0.79852076
123MP0003984_embryonic_growth_retardation0.79728639

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)3.26214982
2Myokymia (HP:0002411)2.69311292
3Epileptic encephalopathy (HP:0200134)2.53775645
4Shoulder girdle muscle weakness (HP:0003547)2.51051060
5Focal motor seizures (HP:0011153)2.47257386
6Pheochromocytoma (HP:0002666)2.43405287
7Insidious onset (HP:0003587)2.40087748
8Termporal pattern (HP:0011008)2.40087748
9Abnormality of glycolysis (HP:0004366)2.38279877
10Progressive cerebellar ataxia (HP:0002073)2.37815832
11Hepatoblastoma (HP:0002884)2.27846077
12Papillary thyroid carcinoma (HP:0002895)2.24601018
13Volvulus (HP:0002580)2.16537212
14Genetic anticipation (HP:0003743)2.15839606
15Neoplasm of the peripheral nervous system (HP:0100007)2.15145286
16Short 4th metacarpal (HP:0010044)2.13640241
17Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.13640241
18Increased serum pyruvate (HP:0003542)2.10301522
19Aplasia/Hypoplasia of the sternum (HP:0006714)2.09780557
20Neuroendocrine neoplasm (HP:0100634)2.03949613
21Focal seizures (HP:0007359)1.99355124
22Septo-optic dysplasia (HP:0100842)1.98582086
23Megalencephaly (HP:0001355)1.96136678
24Gait imbalance (HP:0002141)1.95174324
25Atrophy/Degeneration involving motor neurons (HP:0007373)1.93745889
26Atonic seizures (HP:0010819)1.91640871
27Astrocytoma (HP:0009592)1.90390893
28Abnormality of the astrocytes (HP:0100707)1.90390893
29Limb dystonia (HP:0002451)1.88810642
30Abnormal hair whorl (HP:0010721)1.88614212
31Pelvic girdle muscle weakness (HP:0003749)1.87577592
32Poor suck (HP:0002033)1.85786096
33Abnormality of the hip-girdle musculature (HP:0001445)1.84844209
34Abnormality of the musculature of the pelvis (HP:0001469)1.84844209
35Broad-based gait (HP:0002136)1.84414285
36Increased nuchal translucency (HP:0010880)1.84110143
37Colon cancer (HP:0003003)1.83321649
38Abnormality of the anterior horn cell (HP:0006802)1.81615004
39Degeneration of anterior horn cells (HP:0002398)1.81615004
40Drooling (HP:0002307)1.81391342
41Excessive salivation (HP:0003781)1.81391342
42Aqueductal stenosis (HP:0002410)1.81197641
43Cerebral hypomyelination (HP:0006808)1.80893137
44Anophthalmia (HP:0000528)1.80411388
45High anterior hairline (HP:0009890)1.79809396
46Abnormality of the aortic arch (HP:0012303)1.78957817
47Absent eyebrow (HP:0002223)1.77986805
48Renal duplication (HP:0000075)1.77981234
49Medulloblastoma (HP:0002885)1.77565241
50Abnormality of the corticospinal tract (HP:0002492)1.77024329
51Pointed chin (HP:0000307)1.76247688
52Specific learning disability (HP:0001328)1.75013537
53Asymmetry of the thorax (HP:0001555)1.73930687
54Visual hallucinations (HP:0002367)1.73085883
55Ankle clonus (HP:0011448)1.72792161
56Amyotrophic lateral sclerosis (HP:0007354)1.72521614
57Sleep apnea (HP:0010535)1.72261221
58Congenital malformation of the right heart (HP:0011723)1.72059896
59Double outlet right ventricle (HP:0001719)1.72059896
60Oligodactyly (HP:0012165)1.69827569
61Preaxial hand polydactyly (HP:0001177)1.68929026
62Thyroid carcinoma (HP:0002890)1.67937103
63Chromosomal breakage induced by crosslinking agents (HP:0003221)1.67780367
64Urinary bladder sphincter dysfunction (HP:0002839)1.67386374
65Neoplasm of the adrenal cortex (HP:0100641)1.66614430
66Neoplasm of the adrenal gland (HP:0100631)1.66451977
67Spastic diplegia (HP:0001264)1.65115666
68Chromsome breakage (HP:0040012)1.64614484
69Abnormality of the lower motor neuron (HP:0002366)1.64319091
70Abnormality of the metopic suture (HP:0005556)1.64106352
71Acute necrotizing encephalopathy (HP:0006965)1.64103966
72Lissencephaly (HP:0001339)1.60907842
73Impaired vibration sensation in the lower limbs (HP:0002166)1.60613544
74Hyperthyroidism (HP:0000836)1.60311150
75Action tremor (HP:0002345)1.60232568
76Hyperinsulinemic hypoglycemia (HP:0000825)1.59996274
77Urinary urgency (HP:0000012)1.59878842
78Genital tract atresia (HP:0001827)1.59569292
79Renal agenesis (HP:0000104)1.58509213
80Vaginal atresia (HP:0000148)1.57051948
81Heterochromia iridis (HP:0001100)1.55320920
82Absent septum pellucidum (HP:0001331)1.55015033
83Obstructive sleep apnea (HP:0002870)1.54975197
84Hyperventilation (HP:0002883)1.54664114
85Trigonocephaly (HP:0000243)1.54578521
86Insomnia (HP:0100785)1.54074603
87Oligodactyly (hands) (HP:0001180)1.53952216
88Intestinal atresia (HP:0011100)1.53469138
89Congenital primary aphakia (HP:0007707)1.53177437
90Cutaneous finger syndactyly (HP:0010554)1.52504111
91Renal hypoplasia (HP:0000089)1.52407663
92Epileptiform EEG discharges (HP:0011182)1.52310664
93Relative macrocephaly (HP:0004482)1.52028680
94Gastroesophageal reflux (HP:0002020)1.51834517
95Midline defect of the nose (HP:0004122)1.51688035
96Mutism (HP:0002300)1.51577691
97Hypoglycemic seizures (HP:0002173)1.51298218
98Broad alveolar ridges (HP:0000187)1.51059870
99Glioma (HP:0009733)1.50822953
100Nephrogenic diabetes insipidus (HP:0009806)1.49855755
101Abdominal situs inversus (HP:0003363)1.49813352
102Abnormality of abdominal situs (HP:0011620)1.49813352
103Cortical dysplasia (HP:0002539)1.49772115
104Abnormal lung lobation (HP:0002101)1.49742172
105Inappropriate behavior (HP:0000719)1.48568191
106Progressive macrocephaly (HP:0004481)1.47635615
107Abnormality of the 4th metacarpal (HP:0010012)1.47473386
108Generalized tonic-clonic seizures (HP:0002069)1.46965502
109Cutaneous syndactyly (HP:0012725)1.46735720
110Prominent metopic ridge (HP:0005487)1.46707041
111Supernumerary spleens (HP:0009799)1.46532137
112EEG with generalized epileptiform discharges (HP:0011198)1.46027795
113Generalized hypotonia (HP:0001290)1.45955866
114Patellar aplasia (HP:0006443)1.45863110
115Overriding aorta (HP:0002623)1.45817822
116Agitation (HP:0000713)1.45793173
117Hypsarrhythmia (HP:0002521)1.45771655
118Failure to thrive in infancy (HP:0001531)1.45271221
119Acute encephalopathy (HP:0006846)1.45257890
120Ependymoma (HP:0002888)1.45134555
121Absent radius (HP:0003974)1.44862300
122Postnatal microcephaly (HP:0005484)1.44788173
123Enlarged penis (HP:0000040)1.44200460
124Sclerocornea (HP:0000647)1.43832534
125Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.43414130
126Degeneration of the lateral corticospinal tracts (HP:0002314)1.43414130
127Facial cleft (HP:0002006)1.43305442
128Abnormal mitochondria in muscle tissue (HP:0008316)1.42716628
129Absence seizures (HP:0002121)1.42522747
130Amblyopia (HP:0000646)1.42476056
131Meckel diverticulum (HP:0002245)1.42463107
132Occipital encephalocele (HP:0002085)1.42426242
133Microglossia (HP:0000171)1.42386894
134Bifid tongue (HP:0010297)1.41867284
135Embryonal renal neoplasm (HP:0011794)1.41752432
136Shawl scrotum (HP:0000049)1.41629156
137Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.41244283
138Absent epiphyses (HP:0010577)1.41244283
139Hemiparesis (HP:0001269)1.41164368
140Abnormality of the septum pellucidum (HP:0007375)1.40765512
141Optic nerve hypoplasia (HP:0000609)1.40688134
142Nephroblastoma (Wilms tumor) (HP:0002667)1.40401755
143Aplasia/Hypoplasia of the patella (HP:0006498)1.40245566
144Abnormal number of incisors (HP:0011064)1.39948625
145Absent forearm bone (HP:0003953)1.39579139
146Aplasia involving forearm bones (HP:0009822)1.39579139
147Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.39419147
148Micropenis (HP:0000054)1.39178325
149Adrenal hypoplasia (HP:0000835)1.38341567
150Polyphagia (HP:0002591)1.38170464
151Coronal craniosynostosis (HP:0004440)1.38145082
152Hypoplastic female external genitalia (HP:0012815)1.38090727
153Broad foot (HP:0001769)1.37917458
154Hypoplasia of the capital femoral epiphysis (HP:0003090)1.37024394
155Medial flaring of the eyebrow (HP:0010747)1.36735630
156Hemivertebrae (HP:0002937)1.35624142
157Hypoglycemic coma (HP:0001325)1.34858898

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.90542549
2CASK2.93175702
3VRK22.60627535
4MINK12.56076686
5ERBB32.37344133
6LATS22.28752299
7LIMK12.25602730
8NEK12.22876727
9NTRK32.21166954
10TRIM282.14458947
11CDC72.14246897
12MAP3K41.98905999
13MAP3K91.92802282
14KSR11.89320588
15TNIK1.88029644
16BCR1.87816276
17TSSK61.87702902
18MKNK11.87010831
19SIK31.76839938
20TAF11.76353256
21AKT31.72821289
22MAPK131.64432607
23MKNK21.64143345
24PNCK1.54177319
25TESK11.53059101
26MAP2K71.52241126
27CCNB11.48467703
28DYRK21.40223729
29PRPF4B1.37514941
30* PLK31.33714879
31STK241.30777877
32* PLK21.30298498
33NTRK21.27626255
34EPHA41.24621878
35BRSK11.24116825
36UHMK11.22672778
37CDK181.21636507
38PRKD31.21116664
39CSNK1G11.19760736
40STK161.19230489
41SRPK11.14408930
42MST41.13806566
43SGK21.12151628
44PAK61.10177214
45PBK1.09636007
46CDK151.08100054
47DAPK11.05818900
48ALK1.05483555
49MAP3K121.04389512
50EPHB21.03542045
51* CDK141.03068668
52SGK2231.02298688
53SGK4941.02298688
54BUB10.98008613
55DAPK20.94960246
56CDK11A0.94613799
57SMG10.92124492
58FGFR20.91671517
59BRSK20.86649161
60VRK10.85095137
61EIF2AK10.84402564
62STK390.82400565
63PHKG20.81477262
64PHKG10.81477262
65SGK30.80779836
66TESK20.80190707
67CDK50.80126931
68PRKCG0.79964448
69CDK190.79310374
70KSR20.75051843
71FGFR10.74442512
72NUAK10.74352839
73CSNK1G20.73940307
74PAK30.73681479
75CDK120.72037900
76CAMK1G0.71770738
77EIF2AK30.70886025
78PLK10.69277730
79STK30.67859303
80NTRK10.67533796
81BRD40.66738012
82MAP2K40.65677450
83STK38L0.64731979
84CSNK1G30.64318055
85AURKA0.64121076
86AURKB0.62173201
87DYRK1A0.61315911
88WEE10.60974471
89DMPK0.60756509
90BMPR20.59566933
91RPS6KA20.58718290
92EIF2AK20.57967837
93MAPKAPK50.57896968
94ERBB40.56895068
95CHEK10.56847157
96CDK80.56280103
97ATM0.55448938
98FER0.54935855
99ROCK20.54514284
100CDK20.54025992
101CAMK2B0.53857330
102DYRK30.53548498
103RPS6KA40.53541494
104CDK10.53535135
105CSNK1A1L0.53449382
106PAK40.53143537
107CSNK1E0.52871946
108ARAF0.52283527
109CHEK20.51431383
110PRKDC0.51174682
111CAMK2D0.50593356
112AKT20.50333931
113BRAF0.49210837
114PTK20.48819592
115PLK40.48590865
116WNK40.47434112
117SCYL20.46412658
118WNK30.45914106
119PRKCI0.44831220
120ROCK10.44628380
121NEK20.44391029
122MAPK100.43924792
123BMPR1B0.43918088
124TYRO30.43912368
125CAMK2A0.42458012
126NEK60.42326833
127CAMKK10.41555301
128ATR0.41505936
129TTK0.41018510
130GSK3B0.39921902
131RPS6KB10.38645999
132ILK0.38074944

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.53553596
2Nicotine addiction_Homo sapiens_hsa050332.07632119
3Long-term potentiation_Homo sapiens_hsa047201.96646628
4Protein export_Homo sapiens_hsa030601.90179976
5Dopaminergic synapse_Homo sapiens_hsa047281.86381357
6Vitamin B6 metabolism_Homo sapiens_hsa007501.81036815
7* Oocyte meiosis_Homo sapiens_hsa041141.80966399
8Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.75493363
9Olfactory transduction_Homo sapiens_hsa047401.75266423
10Circadian entrainment_Homo sapiens_hsa047131.74699870
11Steroid biosynthesis_Homo sapiens_hsa001001.73573880
12Amphetamine addiction_Homo sapiens_hsa050311.72729519
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.72440079
14Non-homologous end-joining_Homo sapiens_hsa034501.69339831
15Axon guidance_Homo sapiens_hsa043601.66562319
16mRNA surveillance pathway_Homo sapiens_hsa030151.60896052
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.60290418
18RNA transport_Homo sapiens_hsa030131.59885993
19* Hippo signaling pathway_Homo sapiens_hsa043901.58112756
20* Cell cycle_Homo sapiens_hsa041101.53990141
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.52756919
22GABAergic synapse_Homo sapiens_hsa047271.51994324
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.48950767
24Hedgehog signaling pathway_Homo sapiens_hsa043401.47938053
25Endometrial cancer_Homo sapiens_hsa052131.46914072
26Biosynthesis of amino acids_Homo sapiens_hsa012301.46908608
27Colorectal cancer_Homo sapiens_hsa052101.43843789
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.43319889
29Pyruvate metabolism_Homo sapiens_hsa006201.42284366
30Glutamatergic synapse_Homo sapiens_hsa047241.40981583
31Long-term depression_Homo sapiens_hsa047301.40833095
32Basal cell carcinoma_Homo sapiens_hsa052171.39999687
33Spliceosome_Homo sapiens_hsa030401.36526183
34Melanogenesis_Homo sapiens_hsa049161.35861432
35Morphine addiction_Homo sapiens_hsa050321.34978498
36Cholinergic synapse_Homo sapiens_hsa047251.34109594
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.33226817
38Fatty acid elongation_Homo sapiens_hsa000621.32790179
39Glioma_Homo sapiens_hsa052141.32586035
40Gap junction_Homo sapiens_hsa045401.32208015
41Parkinsons disease_Homo sapiens_hsa050121.31487358
42Oxidative phosphorylation_Homo sapiens_hsa001901.31166262
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.30622505
44Propanoate metabolism_Homo sapiens_hsa006401.30414398
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26554899
46Wnt signaling pathway_Homo sapiens_hsa043101.26007574
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.25444412
48Vibrio cholerae infection_Homo sapiens_hsa051101.23027987
49Carbon metabolism_Homo sapiens_hsa012001.21821531
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.21718173
51Serotonergic synapse_Homo sapiens_hsa047261.20945417
52Base excision repair_Homo sapiens_hsa034101.19319228
53ErbB signaling pathway_Homo sapiens_hsa040121.18687611
54Insulin secretion_Homo sapiens_hsa049111.18647222
55Cocaine addiction_Homo sapiens_hsa050301.15490697
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15354848
57Huntingtons disease_Homo sapiens_hsa050161.13488816
58Collecting duct acid secretion_Homo sapiens_hsa049661.11519342
59Folate biosynthesis_Homo sapiens_hsa007901.11445464
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08841257
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08766665
62Fanconi anemia pathway_Homo sapiens_hsa034601.07738829
63Estrogen signaling pathway_Homo sapiens_hsa049151.05446172
64Tight junction_Homo sapiens_hsa045301.03420504
65Renal cell carcinoma_Homo sapiens_hsa052111.03012626
66Homologous recombination_Homo sapiens_hsa034401.02286663
67Oxytocin signaling pathway_Homo sapiens_hsa049211.02132748
68Thyroid cancer_Homo sapiens_hsa052161.01806245
69Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01468178
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01112048
71Mismatch repair_Homo sapiens_hsa034300.99055552
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.99016808
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.97298117
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.96426886
75Gastric acid secretion_Homo sapiens_hsa049710.96407155
76One carbon pool by folate_Homo sapiens_hsa006700.95966317
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94999538
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94713689
79Alzheimers disease_Homo sapiens_hsa050100.93813475
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93441129
81Melanoma_Homo sapiens_hsa052180.90252701
82Renin secretion_Homo sapiens_hsa049240.89842813
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89373860
84* Neurotrophin signaling pathway_Homo sapiens_hsa047220.89037097
85Phototransduction_Homo sapiens_hsa047440.87511225
86Adherens junction_Homo sapiens_hsa045200.87431562
87Arginine and proline metabolism_Homo sapiens_hsa003300.85813541
88Taste transduction_Homo sapiens_hsa047420.85675245
89TGF-beta signaling pathway_Homo sapiens_hsa043500.85400538
90GnRH signaling pathway_Homo sapiens_hsa049120.84611273
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84406838
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.83898130
93MicroRNAs in cancer_Homo sapiens_hsa052060.83328088
94Proteasome_Homo sapiens_hsa030500.82877059
95Salivary secretion_Homo sapiens_hsa049700.82203829
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82185166
97Basal transcription factors_Homo sapiens_hsa030220.82008390
98Fatty acid metabolism_Homo sapiens_hsa012120.78672617
99Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77720736
100DNA replication_Homo sapiens_hsa030300.77720328
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76166166
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74916070
103Pyrimidine metabolism_Homo sapiens_hsa002400.74462224
104Butanoate metabolism_Homo sapiens_hsa006500.72936945
105Non-small cell lung cancer_Homo sapiens_hsa052230.71978158
106RNA polymerase_Homo sapiens_hsa030200.71923821
107mTOR signaling pathway_Homo sapiens_hsa041500.71336214
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71284079
109MAPK signaling pathway_Homo sapiens_hsa040100.68242686
110beta-Alanine metabolism_Homo sapiens_hsa004100.67888822
111Alcoholism_Homo sapiens_hsa050340.67622404
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66495954
113Dilated cardiomyopathy_Homo sapiens_hsa054140.66243483
114Selenocompound metabolism_Homo sapiens_hsa004500.65922515
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65448477
116Dorso-ventral axis formation_Homo sapiens_hsa043200.65060592
117cAMP signaling pathway_Homo sapiens_hsa040240.64910675
118Purine metabolism_Homo sapiens_hsa002300.64076046
119RNA degradation_Homo sapiens_hsa030180.63853714
120Proteoglycans in cancer_Homo sapiens_hsa052050.63490273
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63350590
122Rap1 signaling pathway_Homo sapiens_hsa040150.63097875
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.62382859
124Nucleotide excision repair_Homo sapiens_hsa034200.61779185
125Calcium signaling pathway_Homo sapiens_hsa040200.60921319
126Ras signaling pathway_Homo sapiens_hsa040140.60250788
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57473547
128Prostate cancer_Homo sapiens_hsa052150.57216890
129Pathways in cancer_Homo sapiens_hsa052000.56213261
130Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56107527
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56095786
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54246224
133Type II diabetes mellitus_Homo sapiens_hsa049300.54235616
134Cardiac muscle contraction_Homo sapiens_hsa042600.53921172
135Insulin signaling pathway_Homo sapiens_hsa049100.52416152
136Lysine degradation_Homo sapiens_hsa003100.51266274
137Endocytosis_Homo sapiens_hsa041440.50736301
138Pancreatic cancer_Homo sapiens_hsa052120.50118361
139Viral myocarditis_Homo sapiens_hsa054160.49287215
140Glutathione metabolism_Homo sapiens_hsa004800.47358387
141Thyroid hormone synthesis_Homo sapiens_hsa049180.46677150
142Glucagon signaling pathway_Homo sapiens_hsa049220.45132217
143Pentose phosphate pathway_Homo sapiens_hsa000300.44896015
144Metabolic pathways_Homo sapiens_hsa011000.39497174
145Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35072512

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »