ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA double-strand break processing (GO:0000729)	5.72266760
2	cullin deneddylation (GO:0010388)	5.10256188
3	protein neddylation (GO:0045116)	4.92914039
4	protein deneddylation (GO:0000338)	4.85412562
5	DNA deamination (GO:0045006)	4.83009723
6	tryptophan catabolic process (GO:0006569)	4.49829756
7	indole-containing compound catabolic process (GO:0042436)	4.49829756
8	indolalkylamine catabolic process (GO:0046218)	4.49829756
9	kynurenine metabolic process (GO:0070189)	4.30536300
10	tryptophan metabolic process (GO:0006568)	4.01075050
11	water-soluble vitamin biosynthetic process (GO:0042364)	3.78738977
12	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.72194639
13	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.70209637
14	inner mitochondrial membrane organization (GO:0007007)	3.70181021
15	ATP synthesis coupled proton transport (GO:0015986)	3.66020845
16	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.66020845
17	protein-cofactor linkage (GO:0018065)	3.64020892
18	chaperone-mediated protein transport (GO:0072321)	3.58379627
19	DNA catabolic process, exonucleolytic (GO:0000738)	3.57318934
20	behavioral response to nicotine (GO:0035095)	3.54161897
21	proteasome assembly (GO:0043248)	3.39471324
22	response to pheromone (GO:0019236)	3.32843466
23	organelle disassembly (GO:1903008)	3.28651149
24	DNA damage response, detection of DNA damage (GO:0042769)	3.27936721
25	piRNA metabolic process (GO:0034587)	3.22821755
26	ribonucleoprotein complex disassembly (GO:0032988)	3.21099678
27	indolalkylamine metabolic process (GO:0006586)	3.20874690
28	negative regulation of telomere maintenance (GO:0032205)	3.17956267
29	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.16975626
30	fucose catabolic process (GO:0019317)	3.13284547
31	L-fucose metabolic process (GO:0042354)	3.13284547
32	L-fucose catabolic process (GO:0042355)	3.13284547
33	electron transport chain (GO:0022900)	3.02794830
34	respiratory electron transport chain (GO:0022904)	3.02059470
35	platelet dense granule organization (GO:0060155)	3.01813278
36	protein K6-linked ubiquitination (GO:0085020)	3.01296460
37	protein complex biogenesis (GO:0070271)	3.00074226
38	positive regulation of mitochondrial fission (GO:0090141)	2.96386664
39	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.96380798
40	GMP metabolic process (GO:0046037)	2.94563248
41	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.94493611
42	cellular biogenic amine catabolic process (GO:0042402)	2.94426991
43	amine catabolic process (GO:0009310)	2.94426991
44	pyrimidine nucleobase catabolic process (GO:0006208)	2.91747910
45	cornea development in camera-type eye (GO:0061303)	2.91387177
46	mitochondrial respiratory chain complex assembly (GO:0033108)	2.90825977
47	DNA methylation involved in gamete generation (GO:0043046)	2.89424500
48	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.85839056
49	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.85782771
50	NADH dehydrogenase complex assembly (GO:0010257)	2.85782771
51	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.85782771
52	negative regulation of mast cell activation (GO:0033004)	2.85504687
53	aldehyde catabolic process (GO:0046185)	2.82284895
54	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.81912176
55	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.81074869
56	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.80229561
57	positive regulation of prostaglandin secretion (GO:0032308)	2.76841131
58	transcription from mitochondrial promoter (GO:0006390)	2.71367488
59	oxidative phosphorylation (GO:0006119)	2.71031631
60	maturation of 5.8S rRNA (GO:0000460)	2.69363186
61	mannosylation (GO:0097502)	2.68075210
62	tRNA modification (GO:0006400)	2.62815857
63	regulation of cellular amino acid metabolic process (GO:0006521)	2.59967601
64	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.57916627
65	regulation of cilium movement (GO:0003352)	2.56827628
66	hydrogen ion transmembrane transport (GO:1902600)	2.56638496
67	regulation of helicase activity (GO:0051095)	2.55015030
68	tRNA processing (GO:0008033)	2.53525145
69	pseudouridine synthesis (GO:0001522)	2.53170894
70	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.52553041
71	L-methionine salvage (GO:0071267)	2.51910543
72	L-methionine biosynthetic process (GO:0071265)	2.51910543
73	amino acid salvage (GO:0043102)	2.51910543
74	glial cell proliferation (GO:0014009)	2.50880117
75	peptidyl-arginine methylation (GO:0018216)	2.50578777
76	peptidyl-arginine N-methylation (GO:0035246)	2.50578777
77	DNA strand renaturation (GO:0000733)	2.47970678
78	termination of RNA polymerase III transcription (GO:0006386)	2.47473067
79	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.47473067
80	regulation of action potential (GO:0098900)	2.47319466
81	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.46190534
82	inositol phosphate dephosphorylation (GO:0046855)	2.45792383
83	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.45792383
84	UTP metabolic process (GO:0046051)	2.45447362
85	proton transport (GO:0015992)	2.44697808
86	GTP biosynthetic process (GO:0006183)	2.44438505
87	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.43180712
88	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.43037395
89	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.41604296
90	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.41604296
91	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.41604296
92	gamma-aminobutyric acid transport (GO:0015812)	2.40924766
93	neural tube formation (GO:0001841)	2.39685962
94	indole-containing compound metabolic process (GO:0042430)	2.39651206
95	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.39593068
96	ovulation cycle (GO:0042698)	2.38417256
97	hydrogen transport (GO:0006818)	2.38409897
98	non-recombinational repair (GO:0000726)	2.36810632
99	double-strand break repair via nonhomologous end joining (GO:0006303)	2.36810632
100	regulation of prostaglandin secretion (GO:0032306)	2.36544171

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.10924707
2	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.04703670
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.61790098
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.31822987
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.10343527
6	ZNF274_21170338_ChIP-Seq_K562_Hela	3.02039676
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.98945482
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.89907285
9	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.78178162
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.68906884
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.49415746
12	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.43625219
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.38991019
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.37626966
15	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.25011312
16	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.05187970
17	ELK1_19687146_ChIP-ChIP_HELA_Human	1.98829350
18	GBX2_23144817_ChIP-Seq_PC3_Human	1.95510871
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.94934331
20	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.94291153
21	VDR_23849224_ChIP-Seq_CD4+_Human	1.92455882
22	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.87144360
23	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.84688561
24	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.82615126
25	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.80421953
26	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.75965512
27	EWS_26573619_Chip-Seq_HEK293_Human	1.71125390
28	EZH2_22144423_ChIP-Seq_EOC_Human	1.69944062
29	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.67047718
30	VDR_22108803_ChIP-Seq_LS180_Human	1.65938310
31	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.63824120
32	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.62729693
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.58834856
34	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.57231115
35	IRF1_19129219_ChIP-ChIP_H3396_Human	1.56301247
36	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.54727159
37	FOXP3_21729870_ChIP-Seq_TREG_Human	1.52574751
38	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.51064184
39	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.50896003
40	P300_19829295_ChIP-Seq_ESCs_Human	1.46040493
41	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.45929588
42	GABP_19822575_ChIP-Seq_HepG2_Human	1.44059631
43	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.43715899
44	ER_23166858_ChIP-Seq_MCF-7_Human	1.38901989
45	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.36818048
46	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.34220497
47	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.34177135
48	FUS_26573619_Chip-Seq_HEK293_Human	1.34064104
49	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.31318746
50	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.30124769
51	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.29828722
52	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.25702750
53	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.22970257
54	TAF15_26573619_Chip-Seq_HEK293_Human	1.22697345
55	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.20606253
56	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.16710924
57	TP53_22573176_ChIP-Seq_HFKS_Human	1.16427031
58	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.16344041
59	DCP1A_22483619_ChIP-Seq_HELA_Human	1.14218179
60	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.13658313
61	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.13658313
62	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.13579710
63	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.13106902
64	SOX2_19829295_ChIP-Seq_ESCs_Human	1.12255658
65	NANOG_19829295_ChIP-Seq_ESCs_Human	1.12255658
66	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.10951842
67	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.09497048
68	NCOR_22424771_ChIP-Seq_293T_Human	1.08230427
69	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.06467022
70	CBP_20019798_ChIP-Seq_JUKART_Human	1.06467022
71	RNF2_27304074_Chip-Seq_NSC_Mouse	1.05953923
72	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.05667484
73	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.02777542
74	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.02650294
75	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.01842668
76	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.01459990
77	TTF2_22483619_ChIP-Seq_HELA_Human	1.00513041
78	AR_20517297_ChIP-Seq_VCAP_Human	1.00470512
79	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.97444344
80	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.97400525
81	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.96768989
82	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96055049
83	REST_19997604_ChIP-ChIP_NEURONS_Mouse	0.95631480
84	REST_21632747_ChIP-Seq_MESCs_Mouse	0.95426429
85	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.95368163
86	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.95067507
87	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.94401038
88	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.93849408
89	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.93119791
90	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.92638171
91	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.92603273
92	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.92216992
93	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.91837090
94	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.91358084
95	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.91252494
96	TAF2_19829295_ChIP-Seq_ESCs_Human	0.90673746
97	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.90554864
98	MYC_19829295_ChIP-Seq_ESCs_Human	0.89154829
99	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.89067978
100	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.85804715

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.83096048
2	MP0002234_abnormal_pharynx_morphology	3.18199786
3	MP0001984_abnormal_olfaction	2.58180983
4	MP0001529_abnormal_vocalization	2.44990185
5	MP0002736_abnormal_nociception_after	2.41011459
6	MP0002163_abnormal_gland_morphology	2.30530074
7	MP0008877_abnormal_DNA_methylation	2.10771127
8	MP0001968_abnormal_touch/_nociception	2.09779752
9	MP0006072_abnormal_retinal_apoptosis	2.07811768
10	MP0004885_abnormal_endolymph	2.07477600
11	MP0008872_abnormal_physiological_respon	2.04991795
12	MP0005084_abnormal_gallbladder_morpholo	2.04585264
13	MP0003718_maternal_effect	1.98512139
14	MP0001986_abnormal_taste_sensitivity	1.96471634
15	MP0005379_endocrine/exocrine_gland_phen	1.96340010
16	MP0002751_abnormal_autonomic_nervous	1.90642458
17	MP0002822_catalepsy	1.90200054
18	MP0003880_abnormal_central_pattern	1.89105249
19	MP0008058_abnormal_DNA_repair	1.85797934
20	MP0005646_abnormal_pituitary_gland	1.81470167
21	MP0005423_abnormal_somatic_nervous	1.81043049
22	MP0002272_abnormal_nervous_system	1.79634496
23	MP0004215_abnormal_myocardial_fiber	1.79318095
24	MP0008789_abnormal_olfactory_epithelium	1.79225723
25	MP0005167_abnormal_blood-brain_barrier	1.78449650
26	MP0002733_abnormal_thermal_nociception	1.77610427
27	MP0003646_muscle_fatigue	1.74365415
28	MP0008875_abnormal_xenobiotic_pharmacok	1.74139308
29	MP0005645_abnormal_hypothalamus_physiol	1.72758753
30	MP0009046_muscle_twitch	1.71062255
31	MP0003806_abnormal_nucleotide_metabolis	1.68920311
32	MP0001188_hyperpigmentation	1.57599436
33	MP0001970_abnormal_pain_threshold	1.56623490
34	MP0004147_increased_porphyrin_level	1.56190760
35	MP0009745_abnormal_behavioral_response	1.54322202
36	MP0005394_taste/olfaction_phenotype	1.51299417
37	MP0005499_abnormal_olfactory_system	1.51299417
38	MP0006276_abnormal_autonomic_nervous	1.50855212
39	MP0006292_abnormal_olfactory_placode	1.48866201
40	MP0008775_abnormal_heart_ventricle	1.48087161
41	MP0010094_abnormal_chromosome_stability	1.47803082
42	MP0006036_abnormal_mitochondrial_physio	1.47741320
43	MP0003693_abnormal_embryo_hatching	1.47417821
44	MP0002735_abnormal_chemical_nociception	1.44047326
45	MP0005551_abnormal_eye_electrophysiolog	1.41989817
46	MP0001486_abnormal_startle_reflex	1.41897310
47	MP0002734_abnormal_mechanical_nocicepti	1.35675179
48	MP0002572_abnormal_emotion/affect_behav	1.32804172
49	MP0004043_abnormal_pH_regulation	1.31782204
50	MP0003121_genomic_imprinting	1.31503089
51	MP0003122_maternal_imprinting	1.31380395
52	MP0003635_abnormal_synaptic_transmissio	1.30436000
53	MP0004145_abnormal_muscle_electrophysio	1.30173899
54	MP0000647_abnormal_sebaceous_gland	1.28031224
55	MP0003186_abnormal_redox_activity	1.27672485
56	MP0006035_abnormal_mitochondrial_morpho	1.22514105
57	MP0005389_reproductive_system_phenotype	1.21915056
58	MP0002160_abnormal_reproductive_system	1.21117476
59	MP0004142_abnormal_muscle_tone	1.20529511
60	MP0004270_analgesia	1.20486859
61	MP0003195_calcinosis	1.18804199
62	MP0005253_abnormal_eye_physiology	1.18757567
63	MP0003787_abnormal_imprinting	1.17932239
64	MP0005410_abnormal_fertilization	1.12883608
65	MP0002332_abnormal_exercise_endurance	1.12711124
66	MP0002837_dystrophic_cardiac_calcinosis	1.10805089
67	MP0002064_seizures	1.10564927
68	MP0001905_abnormal_dopamine_level	1.09224926
69	MP0000613_abnormal_salivary_gland	1.08976326
70	MP0000049_abnormal_middle_ear	1.08510192
71	MP0002876_abnormal_thyroid_physiology	1.08473648
72	MP0009697_abnormal_copulation	1.06711055
73	MP0001919_abnormal_reproductive_system	1.06472115
74	MP0000778_abnormal_nervous_system	1.04160822
75	MP0005266_abnormal_metabolism	1.01819537
76	MP0001764_abnormal_homeostasis	1.01283763
77	MP0002557_abnormal_social/conspecific_i	1.01172317
78	MP0002095_abnormal_skin_pigmentation	1.00542249
79	MP0002184_abnormal_innervation	1.00007781
80	MP0003868_abnormal_feces_composition	0.99135962
81	MP0000372_irregular_coat_pigmentation	0.98772259
82	MP0001485_abnormal_pinna_reflex	0.95521546
83	MP0003119_abnormal_digestive_system	0.93057916
84	MP0004782_abnormal_surfactant_physiolog	0.92016948
85	MP0002063_abnormal_learning/memory/cond	0.91651823
86	MP0004811_abnormal_neuron_physiology	0.88740249
87	MP0001664_abnormal_digestion	0.88557843
88	MP0005623_abnormal_meninges_morphology	0.84273851
89	MP0002909_abnormal_adrenal_gland	0.83969652
90	MP0002229_neurodegeneration	0.82855451
91	MP0005332_abnormal_amino_acid	0.82524452
92	MP0002177_abnormal_outer_ear	0.81829355
93	MP0004859_abnormal_synaptic_plasticity	0.74792517
94	MP0002938_white_spotting	0.74567289
95	MP0002752_abnormal_somatic_nervous	0.73647211
96	MP0000631_abnormal_neuroendocrine_gland	0.72081357
97	MP0000015_abnormal_ear_pigmentation	0.71255834
98	MP0000013_abnormal_adipose_tissue	0.69824201
99	MP0002882_abnormal_neuron_morphology	0.69306449
100	MP0005075_abnormal_melanosome_morpholog	0.69219334

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.45933235
2	Abnormal mitochondria in muscle tissue (HP:0008316)	4.07619506
3	Progressive macrocephaly (HP:0004481)	3.89952730
4	Acute encephalopathy (HP:0006846)	3.72434792
5	Methylmalonic acidemia (HP:0002912)	3.69423039
6	Mitochondrial inheritance (HP:0001427)	3.19467966
7	Cerebral edema (HP:0002181)	3.17445307
8	Hepatic necrosis (HP:0002605)	3.17298084
9	Abnormality of the labia minora (HP:0012880)	3.13514224
10	Methylmalonic aciduria (HP:0012120)	3.11555344
11	Increased CSF lactate (HP:0002490)	3.10494400
12	Lissencephaly (HP:0001339)	3.00041509
13	Hepatocellular necrosis (HP:0001404)	2.95801480
14	Retinal dysplasia (HP:0007973)	2.87962633
15	Aplasia/hypoplasia of the uterus (HP:0008684)	2.77387683
16	Pancreatic cysts (HP:0001737)	2.71529550
17	Pancreatic fibrosis (HP:0100732)	2.70057561
18	Hypomagnesemia (HP:0002917)	2.69334198
19	Drooling (HP:0002307)	2.68331144
20	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.64242730
21	Delayed CNS myelination (HP:0002188)	2.63979724
22	Type II lissencephaly (HP:0007260)	2.59880073
23	Prostate neoplasm (HP:0100787)	2.58024875
24	Sclerocornea (HP:0000647)	2.53882969
25	Hypoplasia of the uterus (HP:0000013)	2.53568413
26	Increased serum lactate (HP:0002151)	2.52026295
27	True hermaphroditism (HP:0010459)	2.48721318
28	Optic disc pallor (HP:0000543)	2.46506734
29	Thyroid-stimulating hormone excess (HP:0002925)	2.45011044
30	Abnormality of methionine metabolism (HP:0010901)	2.44461741
31	Excessive salivation (HP:0003781)	2.42939916
32	Pachygyria (HP:0001302)	2.41555054
33	Palpitations (HP:0001962)	2.41408047
34	Molar tooth sign on MRI (HP:0002419)	2.40496542
35	Abnormality of midbrain morphology (HP:0002418)	2.40496542
36	Abnormality of homocysteine metabolism (HP:0010919)	2.36941291
37	Homocystinuria (HP:0002156)	2.36941291
38	Lactic acidosis (HP:0003128)	2.35507728
39	Degeneration of anterior horn cells (HP:0002398)	2.22037023
40	Abnormality of the anterior horn cell (HP:0006802)	2.22037023
41	Abnormality of magnesium homeostasis (HP:0004921)	2.19821893
42	Neoplasm of the adrenal gland (HP:0100631)	2.18728998
43	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.17866565
44	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.17199304
45	Abolished electroretinogram (ERG) (HP:0000550)	2.14574814
46	Medial flaring of the eyebrow (HP:0010747)	2.14376821
47	Lethargy (HP:0001254)	2.13702609
48	Respiratory failure (HP:0002878)	2.13357403
49	Abnormality of the corticospinal tract (HP:0002492)	2.11524539
50	Abnormality of vitamin B metabolism (HP:0004340)	2.08522989
51	Attenuation of retinal blood vessels (HP:0007843)	2.08367718
52	Aplastic anemia (HP:0001915)	2.02555622
53	Neuroendocrine neoplasm (HP:0100634)	1.98822278
54	Tongue fasciculations (HP:0001308)	1.98223251
55	Dicarboxylic aciduria (HP:0003215)	1.97463268
56	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.97463268
57	Leukodystrophy (HP:0002415)	1.97404520
58	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.95026342
59	Abnormality of alanine metabolism (HP:0010916)	1.95026342
60	Hyperalaninemia (HP:0003348)	1.95026342
61	Hypothermia (HP:0002045)	1.93683033
62	Colon cancer (HP:0003003)	1.90757288
63	Opisthotonus (HP:0002179)	1.89465480
64	Type 2 muscle fiber atrophy (HP:0003554)	1.88735101
65	Broad-based gait (HP:0002136)	1.88449996
66	Patellar aplasia (HP:0006443)	1.87959964
67	Cerebellar dysplasia (HP:0007033)	1.87740419
68	Abnormality of serum amino acid levels (HP:0003112)	1.86077963
69	Hypoglycemic coma (HP:0001325)	1.85473557
70	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.85123718
71	Stomach cancer (HP:0012126)	1.84822883
72	Hyperglycinemia (HP:0002154)	1.82904045
73	Renal cortical cysts (HP:0000803)	1.82611202
74	Agitation (HP:0000713)	1.81382470
75	Late onset (HP:0003584)	1.78303717
76	Aplasia/Hypoplasia of the patella (HP:0006498)	1.78258389
77	CNS demyelination (HP:0007305)	1.77566047
78	Generalized aminoaciduria (HP:0002909)	1.77234393
79	Cerebral hypomyelination (HP:0006808)	1.75091037
80	Dandy-Walker malformation (HP:0001305)	1.74741308
81	Abnormal rod and cone electroretinograms (HP:0008323)	1.74391384
82	Abnormality of the renal cortex (HP:0011035)	1.73915264
83	Gait imbalance (HP:0002141)	1.70973864
84	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.70186074
85	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.70186074
86	Furrowed tongue (HP:0000221)	1.70156317
87	Microvesicular hepatic steatosis (HP:0001414)	1.70096754
88	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.69397636
89	Pheochromocytoma (HP:0002666)	1.68793674
90	Constricted visual fields (HP:0001133)	1.67523337
91	Hemiparesis (HP:0001269)	1.67374183
92	Exercise intolerance (HP:0003546)	1.67370745
93	Chronic hepatic failure (HP:0100626)	1.65441227
94	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.64543937
95	Bony spicule pigmentary retinopathy (HP:0007737)	1.64147078
96	Ulnar claw (HP:0001178)	1.63491375
97	X-linked dominant inheritance (HP:0001423)	1.61378806
98	Fibular aplasia (HP:0002990)	1.60843976
99	Cystic liver disease (HP:0006706)	1.60152334
100	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.58593235

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	4.20614814
2	ZAK	3.21242843
3	VRK2	2.70813689
4	NUAK1	2.68196238
5	TAOK3	2.67068277
6	BMPR1B	2.65313936
7	TLK1	2.42626430
8	TRIM28	2.36178635
9	TIE1	2.32540466
10	EIF2AK3	2.12867090
11	BCR	2.07214278
12	EIF2AK1	2.01789128
13	VRK1	2.01615541
14	WNK3	2.00531019
15	MAPK13	1.97233601
16	BCKDK	1.97180430
17	FRK	1.81985089
18	PHKG2	1.80288132
19	PHKG1	1.80288132
20	MST4	1.76242517
21	CSNK1G3	1.65109611
22	SRPK1	1.64053646
23	ERBB3	1.63959183
24	CSNK1G2	1.62391696
25	PLK2	1.59431008
26	DYRK2	1.56456770
27	MARK1	1.54461937
28	MAPKAPK3	1.48207669
29	GRK1	1.47925345
30	CSNK1A1L	1.46393227
31	PLK3	1.42486459
32	CASK	1.42453494
33	MAP2K7	1.37598597
34	TNIK	1.33226411
35	CSNK1G1	1.26660422
36	NEK1	1.18613702
37	KDR	1.18029816
38	MINK1	1.16051660
39	LIMK1	1.15758981
40	RPS6KA4	1.13362800
41	MAPKAPK5	1.10720946
42	EPHA3	1.09438508
43	BUB1	1.09153164
44	ADRBK2	1.04943596
45	RPS6KA5	1.01836010
46	STK39	1.00815469
47	SIK3	0.97933788
48	MKNK2	0.93422677
49	PINK1	0.93408751
50	SCYL2	0.91940196
51	OXSR1	0.86186990
52	SIK2	0.83953943
53	MAP3K4	0.83151576
54	FER	0.81691047
55	DAPK2	0.78233658
56	INSRR	0.75199168
57	TESK1	0.71642104
58	CDK8	0.69445890
59	PLK4	0.68726796
60	WNK4	0.67327550
61	TRPM7	0.63885020
62	TSSK6	0.63254431
63	CDC7	0.60288020
64	NEK2	0.57947835
65	PRKCE	0.57826051
66	EIF2AK2	0.56201477
67	DAPK1	0.54353277
68	DYRK3	0.52794157
69	TAF1	0.52639290
70	ATR	0.52420665
71	PIK3CA	0.52406323
72	AURKA	0.51739599
73	PRKCG	0.49914487
74	EPHA4	0.47303277
75	MKNK1	0.46641480
76	CHEK2	0.45407655
77	CAMK2D	0.44980142
78	MAP4K2	0.44655843
79	EPHB2	0.42920443
80	PLK1	0.42899118
81	TESK2	0.40634928
82	PNCK	0.40117864
83	ATM	0.39652566
84	KIT	0.39044839
85	GRK5	0.36818440
86	CAMK2A	0.36279280
87	GRK7	0.36126339
88	PDK2	0.35189354
89	CSNK1A1	0.35005217
90	CDK14	0.34708794
91	LMTK2	0.34616036
92	DAPK3	0.33011611
93	CHEK1	0.32598489
94	PRKACA	0.32398755
95	PRKCI	0.32114892
96	RPS6KB2	0.32041825
97	CDK9	0.31336606
98	EEF2K	0.30054467
99	ALK	0.29424081
100	CSNK2A1	0.26298154

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	4.18398280
2	Proteasome_Homo sapiens_hsa03050	3.24941097
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.19232014
4	Protein export_Homo sapiens_hsa03060	3.02854397
5	Parkinsons disease_Homo sapiens_hsa05012	2.94754404
6	RNA polymerase_Homo sapiens_hsa03020	2.61867907
7	Mismatch repair_Homo sapiens_hsa03430	2.06289616
8	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.98903226
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.92774368
10	Huntingtons disease_Homo sapiens_hsa05016	1.85172400
11	Linoleic acid metabolism_Homo sapiens_hsa00591	1.76077942
12	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.73241893
13	Fatty acid elongation_Homo sapiens_hsa00062	1.72241588
14	Phototransduction_Homo sapiens_hsa04744	1.72014583
15	Alzheimers disease_Homo sapiens_hsa05010	1.70278125
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.58290856
17	Spliceosome_Homo sapiens_hsa03040	1.57119626
18	Homologous recombination_Homo sapiens_hsa03440	1.52159885
19	DNA replication_Homo sapiens_hsa03030	1.51792374
20	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.50013264
21	Steroid biosynthesis_Homo sapiens_hsa00100	1.48315560
22	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.43248609
23	Tryptophan metabolism_Homo sapiens_hsa00380	1.42750448
24	Alcoholism_Homo sapiens_hsa05034	1.39232586
25	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.37995085
26	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.37234687
27	Purine metabolism_Homo sapiens_hsa00230	1.33137591
28	RNA degradation_Homo sapiens_hsa03018	1.31148187
29	Basal transcription factors_Homo sapiens_hsa03022	1.30221128
30	Collecting duct acid secretion_Homo sapiens_hsa04966	1.29769586
31	Asthma_Homo sapiens_hsa05310	1.26530893
32	Nicotine addiction_Homo sapiens_hsa05033	1.26093744
33	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.25784709
34	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.22251522
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.21595900
36	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.19331482
37	Peroxisome_Homo sapiens_hsa04146	1.16133156
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.12988205
39	Fanconi anemia pathway_Homo sapiens_hsa03460	1.11726973
40	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.11085225
41	Propanoate metabolism_Homo sapiens_hsa00640	1.10298858
42	Base excision repair_Homo sapiens_hsa03410	1.07341671
43	Cardiac muscle contraction_Homo sapiens_hsa04260	1.04408982
44	Nucleotide excision repair_Homo sapiens_hsa03420	1.03815192
45	Pyrimidine metabolism_Homo sapiens_hsa00240	1.03780665
46	Pyruvate metabolism_Homo sapiens_hsa00620	1.02934353
47	Butanoate metabolism_Homo sapiens_hsa00650	1.02241243
48	RNA transport_Homo sapiens_hsa03013	0.97808883
49	Ether lipid metabolism_Homo sapiens_hsa00565	0.95959922
50	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.93350665
51	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.90188600
52	Sulfur metabolism_Homo sapiens_hsa00920	0.89139471
53	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.88500286
54	Morphine addiction_Homo sapiens_hsa05032	0.86646209
55	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.86180859
56	Selenocompound metabolism_Homo sapiens_hsa00450	0.85597717
57	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.85576904
58	Type I diabetes mellitus_Homo sapiens_hsa04940	0.84782141
59	Olfactory transduction_Homo sapiens_hsa04740	0.83129833
60	One carbon pool by folate_Homo sapiens_hsa00670	0.81967376
61	Sulfur relay system_Homo sapiens_hsa04122	0.81482924
62	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.80384603
63	GABAergic synapse_Homo sapiens_hsa04727	0.79890116
64	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.78964779
65	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.78893071
66	Non-homologous end-joining_Homo sapiens_hsa03450	0.78890342
67	Vibrio cholerae infection_Homo sapiens_hsa05110	0.72384325
68	Oocyte meiosis_Homo sapiens_hsa04114	0.68887529
69	Metabolic pathways_Homo sapiens_hsa01100	0.67356594
70	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.67344176
71	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.66869600
72	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.64523610
73	Circadian entrainment_Homo sapiens_hsa04713	0.63012616
74	Serotonergic synapse_Homo sapiens_hsa04726	0.60837590
75	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.59932643
76	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.59813882
77	beta-Alanine metabolism_Homo sapiens_hsa00410	0.59466549
78	Rheumatoid arthritis_Homo sapiens_hsa05323	0.59139237
79	Fat digestion and absorption_Homo sapiens_hsa04975	0.58883666
80	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.58661910
81	Glutamatergic synapse_Homo sapiens_hsa04724	0.58180498
82	Nitrogen metabolism_Homo sapiens_hsa00910	0.57942162
83	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.57867386
84	Taste transduction_Homo sapiens_hsa04742	0.56686246
85	Chemical carcinogenesis_Homo sapiens_hsa05204	0.52788663
86	Insulin secretion_Homo sapiens_hsa04911	0.51442308
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.48780576
88	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.48731515
89	Carbon metabolism_Homo sapiens_hsa01200	0.48201893
90	Allograft rejection_Homo sapiens_hsa05330	0.48134505
91	Folate biosynthesis_Homo sapiens_hsa00790	0.47771304
92	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.45890739
93	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.45844874
94	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.41987158
95	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.40923821
96	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.39700304
97	Fatty acid metabolism_Homo sapiens_hsa01212	0.37737523
98	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.36701967
99	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.35914914
100	Antigen processing and presentation_Homo sapiens_hsa04612	0.34161904

YWHAEP5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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