YWHAEP7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cerebellar Purkinje cell differentiation (GO:0021702)8.93906417
2thalamus development (GO:0021794)8.84351359
3peptidyl-arginine omega-N-methylation (GO:0035247)8.74238472
4bone trabecula formation (GO:0060346)8.52918063
5positive regulation of gastrulation (GO:2000543)8.46494868
6forebrain neuron development (GO:0021884)8.27447345
7neurotransmitter catabolic process (GO:0042135)8.24746192
8urogenital system development (GO:0001655)8.22439974
9peptidyl-arginine methylation (GO:0018216)8.07397139
10peptidyl-arginine N-methylation (GO:0035246)8.07397139
11cerebellum development (GO:0021549)7.39328346
12spinal cord association neuron differentiation (GO:0021527)7.12499861
13histone arginine methylation (GO:0034969)7.10581133
14somite rostral/caudal axis specification (GO:0032525)6.34305516
15head development (GO:0060322)6.21657296
16primitive streak formation (GO:0090009)6.13271688
17uterus development (GO:0060065)5.96857165
18retina layer formation (GO:0010842)5.83875881
19hematopoietic stem cell proliferation (GO:0071425)5.78534918
20endoderm formation (GO:0001706)5.66695525
21vagina development (GO:0060068)5.52283270
22glomerulus development (GO:0032835)5.41120495
23embryonic viscerocranium morphogenesis (GO:0048703)5.21464105
24cell differentiation in hindbrain (GO:0021533)5.14206613
25peptidyl-arginine modification (GO:0018195)5.13380023
26behavioral response to nicotine (GO:0035095)5.09917671
27granulocyte differentiation (GO:0030851)5.07096618
28cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.95662703
29viral protein processing (GO:0019082)4.76908294
30central nervous system neuron development (GO:0021954)4.70265319
31positive regulation of protein homooligomerization (GO:0032464)4.58667902
32female genitalia development (GO:0030540)4.54585320
33cranial nerve structural organization (GO:0021604)4.51622568
34regulation of nephron tubule epithelial cell differentiation (GO:0072182)4.49404260
35long term synaptic depression (GO:0060292)4.37200510
36pattern specification involved in kidney development (GO:0061004)4.23205946
37telencephalon development (GO:0021537)4.15702795
38S-adenosylmethionine metabolic process (GO:0046500)4.15085889
39negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.11212140
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.06796605
41positive regulation of T cell apoptotic process (GO:0070234)4.05319964
42regulation of epithelial cell differentiation involved in kidney development (GO:2000696)3.88825642
43motor neuron axon guidance (GO:0008045)3.84596023
44neurotransmitter metabolic process (GO:0042133)3.84278129
45cellular biogenic amine catabolic process (GO:0042402)3.84129704
46amine catabolic process (GO:0009310)3.84129704
47regulation of neuron migration (GO:2001222)3.83876800
48adult feeding behavior (GO:0008343)3.81332543
49positive regulation of protein kinase C signaling (GO:0090037)3.63908769
50negative regulation of axon extension involved in axon guidance (GO:0048843)3.52752387
51catechol-containing compound biosynthetic process (GO:0009713)3.41143901
52catecholamine biosynthetic process (GO:0042423)3.41143901
53epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.40881850
54regulation of thymocyte apoptotic process (GO:0070243)3.38406338
55positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.34119447
56membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.33729409
57cornea development in camera-type eye (GO:0061303)3.28579606
58facial nerve structural organization (GO:0021612)3.26384418
59membrane repolarization during action potential (GO:0086011)3.25183532
60pyrimidine nucleobase catabolic process (GO:0006208)3.23240271
61exocrine pancreas development (GO:0031017)3.21719586
62regulation of sarcomere organization (GO:0060297)3.21565244
63negative regulation of multicellular organism growth (GO:0040015)3.18264084
64imidazole-containing compound metabolic process (GO:0052803)3.15465235
65resolution of meiotic recombination intermediates (GO:0000712)3.10038832
66positive regulation of lymphocyte apoptotic process (GO:0070230)3.09261787
67cell differentiation in spinal cord (GO:0021515)3.08936272
68organic cation transport (GO:0015695)3.07308685
69neuron fate specification (GO:0048665)3.03857069
70regulation of triglyceride catabolic process (GO:0010896)3.01916219
71positive regulation of mesonephros development (GO:0061213)2.91314010
72virion assembly (GO:0019068)2.89227414
73DNA double-strand break processing (GO:0000729)2.88351479
74anatomical structure arrangement (GO:0048532)2.86477029
75dendritic spine morphogenesis (GO:0060997)2.86134339
76positive regulation of embryonic development (GO:0040019)2.83838753
77determination of adult lifespan (GO:0008340)2.81470100
78trabecula formation (GO:0060343)2.80206926
79connective tissue development (GO:0061448)2.74746461
80forebrain neuron differentiation (GO:0021879)2.73866007
81synaptic transmission, cholinergic (GO:0007271)2.70194497
82nucleobase catabolic process (GO:0046113)2.69454676
83negative regulation of cAMP-mediated signaling (GO:0043951)2.64101802
84regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.63587442
85regulation of hippo signaling (GO:0035330)2.63234681
86retinal ganglion cell axon guidance (GO:0031290)2.61200194
87negative regulation of axon guidance (GO:1902668)2.55338894
88negative regulation of interleukin-1 production (GO:0032692)2.53267649
89phenol-containing compound biosynthetic process (GO:0046189)2.51684528
90autophagic vacuole fusion (GO:0000046)2.51443614
91regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.47750153
92positive regulation of triglyceride metabolic process (GO:0090208)2.46803314
93lymphangiogenesis (GO:0001946)2.46465766
94organelle membrane fusion (GO:0090174)2.45948500
95polyamine metabolic process (GO:0006595)2.45151266
96centriole replication (GO:0007099)2.44219495
97DNA demethylation (GO:0080111)2.42851604
98ubiquinone biosynthetic process (GO:0006744)2.41999606
99regulation of T cell tolerance induction (GO:0002664)2.41758881
100embryonic retina morphogenesis in camera-type eye (GO:0060059)11.3921857

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.61939515
2IGF1R_20145208_ChIP-Seq_DFB_Human4.39527479
3EZH2_22144423_ChIP-Seq_EOC_Human3.70219136
4VDR_22108803_ChIP-Seq_LS180_Human2.93237205
5CBX2_27304074_Chip-Seq_ESCs_Mouse2.72861336
6ZNF274_21170338_ChIP-Seq_K562_Hela2.41294542
7CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.37126441
8GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse2.36015102
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.22833769
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.22505266
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17872151
12RNF2_27304074_Chip-Seq_ESCs_Mouse2.11275705
13EZH2_27294783_Chip-Seq_ESCs_Mouse2.01558008
14EZH2_27304074_Chip-Seq_ESCs_Mouse1.98661211
15BMI1_23680149_ChIP-Seq_NPCS_Mouse1.97179953
16EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.93429522
17CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89734074
18POU5F1_16153702_ChIP-ChIP_HESCs_Human1.89508931
19REST_21632747_ChIP-Seq_MESCs_Mouse1.83521844
20STAT6_21828071_ChIP-Seq_BEAS2B_Human1.83267442
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79885691
22IRF1_19129219_ChIP-ChIP_H3396_Human1.79772758
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.69631115
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.69343837
25WDR5_24793694_ChIP-Seq_LNCAP_Human1.64506800
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.62128311
27AR_21572438_ChIP-Seq_LNCaP_Human1.58742896
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55814001
29GBX2_23144817_ChIP-Seq_PC3_Human1.45312101
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44902478
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38276964
32TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.38233368
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.37913852
34SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.35812491
35SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.35416651
36TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35089968
37EWS_26573619_Chip-Seq_HEK293_Human1.34583950
38EZH2_18974828_ChIP-Seq_MESCs_Mouse1.33413313
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.33413313
40NCOR_22424771_ChIP-Seq_293T_Human1.32058927
41ER_23166858_ChIP-Seq_MCF-7_Human1.31118009
42NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28424605
43CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.27967332
44BCAT_22108803_ChIP-Seq_LS180_Human1.27162232
45CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.25021499
46NANOG_20526341_ChIP-Seq_ESCs_Human1.24165720
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23308856
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23308856
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22413202
50ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21664166
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21577868
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21446441
53TP53_22573176_ChIP-Seq_HFKS_Human1.21277294
54KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19319508
55REST_18959480_ChIP-ChIP_MESCs_Mouse1.18870464
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17622630
57P300_19829295_ChIP-Seq_ESCs_Human1.17014895
58RING1B_27294783_Chip-Seq_ESCs_Mouse1.16475950
59AR_25329375_ChIP-Seq_VCAP_Human1.15416628
60SOX2_19829295_ChIP-Seq_ESCs_Human1.15376646
61NANOG_19829295_ChIP-Seq_ESCs_Human1.15376646
62PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13446409
63RUNX2_22187159_ChIP-Seq_PCA_Human1.12511162
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11462857
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10811107
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10695149
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.10341876
68SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.09808918
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.08255537
70STAT3_23295773_ChIP-Seq_U87_Human1.07767284
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06872445
72FOXH1_21741376_ChIP-Seq_ESCs_Human1.06287285
73SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.05512296
74SMAD3_21741376_ChIP-Seq_ESCs_Human1.05233081
75SMAD4_21741376_ChIP-Seq_EPCs_Human1.04643025
76CBP_21632823_ChIP-Seq_H3396_Human1.04210209
77AR_20517297_ChIP-Seq_VCAP_Human1.04062044
78STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.03989917
79FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03836266
80PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03230397
81AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03041559
82MYC_18940864_ChIP-ChIP_HL60_Human1.02993622
83LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02514112
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01713430
85TP53_20018659_ChIP-ChIP_R1E_Mouse0.99443230
86PRDM14_20953172_ChIP-Seq_ESCs_Human0.99104035
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98963910
88SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.97216735
89RNF2_27304074_Chip-Seq_NSC_Mouse0.96924637
90SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.96762762
91OCT1_27270436_Chip-Seq_PROSTATE_Human0.95160216
92ARNT_22903824_ChIP-Seq_MCF-7_Human0.94948294
93CBP_20019798_ChIP-Seq_JUKART_Human0.94502235
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94502235
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93553089
96HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.92829924
97OCT4_20526341_ChIP-Seq_ESCs_Human0.92495911
98TCF4_22108803_ChIP-Seq_LS180_Human0.92340318
99NFE2_27457419_Chip-Seq_LIVER_Mouse0.91210856
100PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90087160

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.23843825
2MP0002138_abnormal_hepatobiliary_system4.03533867
3MP0003880_abnormal_central_pattern4.02749794
4MP0003890_abnormal_embryonic-extraembry3.85960172
5MP0001188_hyperpigmentation3.47003433
6MP0005257_abnormal_intraocular_pressure3.13120303
7MP0002653_abnormal_ependyma_morphology2.84640923
8MP0005171_absent_coat_pigmentation2.48703605
9MP0006276_abnormal_autonomic_nervous2.45837758
10MP0003938_abnormal_ear_development2.34711741
11MP0000049_abnormal_middle_ear2.14341788
12MP0002127_abnormal_cardiovascular_syste2.04806510
13MP0006292_abnormal_olfactory_placode10.4718987
14MP0000538_abnormal_urinary_bladder1.99593216
15MP0008995_early_reproductive_senescence1.94014015
16MP0010368_abnormal_lymphatic_system1.84424348
17MP0002184_abnormal_innervation1.79423886
18MP0008775_abnormal_heart_ventricle1.78063970
19MP0003195_calcinosis1.76578473
20MP0005083_abnormal_biliary_tract1.76414213
21MP0001501_abnormal_sleep_pattern1.67820168
22MP0001879_abnormal_lymphatic_vessel1.65299930
23MP0005248_abnormal_Harderian_gland1.63997402
24MP0001849_ear_inflammation1.53257918
25MP0008789_abnormal_olfactory_epithelium1.40664993
26MP0001502_abnormal_circadian_rhythm1.37245189
27MP0005174_abnormal_tail_pigmentation1.36788717
28MP0000955_abnormal_spinal_cord1.36124165
29MP0001286_abnormal_eye_development1.27219155
30MP0004381_abnormal_hair_follicle1.26389321
31MP0005670_abnormal_white_adipose1.23365813
32MP0003879_abnormal_hair_cell1.17488764
33MP0001485_abnormal_pinna_reflex1.16545274
34MP0002102_abnormal_ear_morphology1.11197113
35MP0006072_abnormal_retinal_apoptosis1.10718804
36MP0004742_abnormal_vestibular_system1.09265978
37MP0005220_abnormal_exocrine_pancreas1.08428096
38MP0009115_abnormal_fat_cell1.08276038
39MP0008932_abnormal_embryonic_tissue1.07632168
40MP0005645_abnormal_hypothalamus_physiol1.06789194
41MP0002837_dystrophic_cardiac_calcinosis1.05389715
42MP0000778_abnormal_nervous_system1.02070922
43MP0002272_abnormal_nervous_system0.98844747
44MP0005084_abnormal_gallbladder_morpholo0.98793694
45MP0003646_muscle_fatigue0.96844686
46MP0000026_abnormal_inner_ear0.96645681
47MP0003385_abnormal_body_wall0.96603439
48MP0005394_taste/olfaction_phenotype0.91859559
49MP0005499_abnormal_olfactory_system0.91859559
50MP0003948_abnormal_gas_homeostasis0.91455819
51MP0004085_abnormal_heartbeat0.91265266
52MP0002210_abnormal_sex_determination0.90539016
53MP0002876_abnormal_thyroid_physiology0.90312706
54MP0001873_stomach_inflammation0.87868955
55MP0001984_abnormal_olfaction0.87700872
56MP0000534_abnormal_ureter_morphology0.86479806
57MP0002557_abnormal_social/conspecific_i0.85092831
58MP0003638_abnormal_response/metabolism_0.84832998
59MP0002882_abnormal_neuron_morphology0.84322642
60MP0001968_abnormal_touch/_nociception0.83683634
61MP0009745_abnormal_behavioral_response0.83509943
62MP0003315_abnormal_perineum_morphology0.83474956
63MP0008872_abnormal_physiological_respon0.81402423
64MP0002095_abnormal_skin_pigmentation0.80523719
65MP0005551_abnormal_eye_electrophysiolog0.79857067
66MP0002735_abnormal_chemical_nociception0.75271569
67MP0003698_abnormal_male_reproductive0.73347344
68MP0000015_abnormal_ear_pigmentation0.72846464
69MP0002877_abnormal_melanocyte_morpholog0.70787852
70MP0002752_abnormal_somatic_nervous0.69634405
71MP0005075_abnormal_melanosome_morpholog0.67931799
72MP0001145_abnormal_male_reproductive0.67680592
73MP0004885_abnormal_endolymph0.67280637
74MP0001963_abnormal_hearing_physiology0.66978585
75MP0003567_abnormal_fetal_cardiomyocyte0.64165666
76MP0001970_abnormal_pain_threshold0.62779886
77MP0004147_increased_porphyrin_level0.62514500
78MP0005423_abnormal_somatic_nervous0.60327130
79MP0003959_abnormal_lean_body0.59719670
80MP0005448_abnormal_energy_balance0.59544672
81MP0003936_abnormal_reproductive_system0.58622338
82MP0002152_abnormal_brain_morphology0.58278181
83MP0002971_abnormal_brown_adipose0.58043255
84MP0003724_increased_susceptibility_to0.57143414
85MP0000653_abnormal_sex_gland0.56358739
86MP0001929_abnormal_gametogenesis0.54925257
87MP0003045_fibrosis0.54779028
88MP0003635_abnormal_synaptic_transmissio0.53350186
89MP0004145_abnormal_muscle_electrophysio0.53242055
90MP0001324_abnormal_eye_pigmentation0.53050741
91MP0000613_abnormal_salivary_gland0.51276305
92MP0002163_abnormal_gland_morphology0.51148043
93MP0002572_abnormal_emotion/affect_behav0.51121790
94MP0001944_abnormal_pancreas_morphology0.50660258
95MP0002229_neurodegeneration0.49950573
96MP0002733_abnormal_thermal_nociception0.49773860
97MP0002638_abnormal_pupillary_reflex0.49017955
98MP0003718_maternal_effect0.48074735
99MP0000647_abnormal_sebaceous_gland0.47881443
100MP0002168_other_aberrant_phenotype0.47631117

Predicted human phenotypes

RankGene SetZ-score
1Abnormal pancreas size (HP:0012094)8.05902033
2Increased serum pyruvate (HP:0003542)5.73792554
3Shawl scrotum (HP:0000049)5.53129283
4Large eyes (HP:0001090)5.04453673
5Abnormality of glycolysis (HP:0004366)4.99135404
6Decreased circulating renin level (HP:0003351)4.97728620
7Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.25098115
8Abnormality of alanine metabolism (HP:0010916)4.25098115
9Hyperalaninemia (HP:0003348)4.25098115
10Metabolic alkalosis (HP:0200114)4.03229795
11Alveolar cell carcinoma (HP:0006519)3.75363784
12Hypoplasia of the capital femoral epiphysis (HP:0003090)3.51997348
13Ulnar claw (HP:0001178)3.49722786
14Cerebellar dysplasia (HP:0007033)3.30175636
15Neoplasm of the tracheobronchial system (HP:0100552)3.20107218
16Irregular vertebral endplates (HP:0003301)3.05200449
17Optic nerve hypoplasia (HP:0000609)3.01795437
18Type II lissencephaly (HP:0007260)2.96635011
19Rhabdomyosarcoma (HP:0002859)2.90013001
20Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.83142552
21Pancreatic cysts (HP:0001737)2.80173710
22Absent epiphyses (HP:0010577)2.79161179
23Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.79161179
24Abnormality of renin-angiotensin system (HP:0000847)2.77395363
25Genu recurvatum (HP:0002816)2.76627206
26Abnormality of the renal cortex (HP:0011035)2.75081150
27Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.67093606
28Disproportionate short-trunk short stature (HP:0003521)2.65159893
29Midline defect of the nose (HP:0004122)2.53318272
30Occipital encephalocele (HP:0002085)2.50180107
31Hypophosphatemic rickets (HP:0004912)2.50085714
32Supranuclear gaze palsy (HP:0000605)2.49858996
33Slow-growing hair (HP:0002217)2.48555122
34Abnormality of hair growth rate (HP:0011363)2.48555122
35Decreased subcutaneous fat (HP:0001002)2.46955125
36Cerebral palsy (HP:0100021)2.46348745
37Meningocele (HP:0002435)2.41538686
38Thoracolumbar scoliosis (HP:0002944)2.39909980
39Absent rod-and cone-mediated responses on ERG (HP:0007688)2.35802719
40Partial agenesis of the corpus callosum (HP:0001338)2.35620376
41Abnormality of the vertebral endplates (HP:0005106)2.34755697
42Neoplasm of striated muscle (HP:0009728)2.34126993
43Absent thumb (HP:0009777)2.33827785
44Abnormal drinking behavior (HP:0030082)2.29819540
45Polydipsia (HP:0001959)2.29819540
46Stomatitis (HP:0010280)2.29475445
47Renal cortical cysts (HP:0000803)2.27436154
48Hypokalemia (HP:0002900)2.26349155
49Retinal dysplasia (HP:0007973)2.26110652
50Abnormality of midbrain morphology (HP:0002418)2.25059470
51Molar tooth sign on MRI (HP:0002419)2.25059470
52Cortical visual impairment (HP:0100704)2.24931394
53Breast carcinoma (HP:0003002)2.18978099
54Inability to walk (HP:0002540)2.18161571
55White forelock (HP:0002211)2.17398561
56Patellar aplasia (HP:0006443)2.16435925
57Maternal diabetes (HP:0009800)2.13839449
58Irregular epiphyses (HP:0010582)2.11592219
59Aplasia/Hypoplasia of the patella (HP:0006498)2.08587233
60Patchy hypopigmentation of hair (HP:0011365)2.05710001
61Severe muscular hypotonia (HP:0006829)2.04668485
62Abnormality of the intervertebral disk (HP:0005108)2.04242889
63Aplasia/Hypoplasia of the spleen (HP:0010451)2.02674266
64Pancreatic fibrosis (HP:0100732)2.02019118
65True hermaphroditism (HP:0010459)2.01980833
66Amaurosis fugax (HP:0100576)2.01281652
67Polyuria (HP:0000103)1.97090448
68Cystic liver disease (HP:0006706)1.95942444
69Progressive inability to walk (HP:0002505)1.95713858
70Abnormality of the right ventricle (HP:0001707)1.95548168
71Alkalosis (HP:0001948)1.94535957
72Epidermoid cyst (HP:0200040)1.94509929
73Subcapsular cataract (HP:0000523)1.94217409
74Abnormality of the renal medulla (HP:0100957)1.89348947
75Oligohydramnios (HP:0001562)1.89163199
76Thick nail (HP:0001805)1.88343386
77Thyroid-stimulating hormone excess (HP:0002925)1.87586544
78Congenital sensorineural hearing impairment (HP:0008527)1.84893939
79Bulbous nose (HP:0000414)1.81996602
80Patent foramen ovale (HP:0001655)1.80668696
81Short chin (HP:0000331)1.80070311
82Abnormality of potassium homeostasis (HP:0011042)1.79859085
83Nephronophthisis (HP:0000090)1.78981737
84Asplenia (HP:0001746)1.78664293
85Lip pit (HP:0100267)1.78013108
86Mesangial abnormality (HP:0001966)1.76419676
87Dandy-Walker malformation (HP:0001305)1.73352978
88Tinnitus (HP:0000360)1.72591319
89Broad nasal tip (HP:0000455)1.72560000
90Abnormal rod and cone electroretinograms (HP:0008323)1.71096368
91Lissencephaly (HP:0001339)1.70748355
92Congenital hepatic fibrosis (HP:0002612)1.70706764
93Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.70116263
94Type I diabetes mellitus (HP:0100651)1.68712326
95Supernumerary bones of the axial skeleton (HP:0009144)1.66926600
96Congenital stationary night blindness (HP:0007642)1.66651771
97Elevated erythrocyte sedimentation rate (HP:0003565)1.66539071
98Sprengel anomaly (HP:0000912)1.65918607
99Biliary tract neoplasm (HP:0100574)1.61733541
100Constricted visual fields (HP:0001133)1.61259344

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK14.83975193
2ADRBK24.10379238
3TAOK33.50922137
4BCKDK3.30696047
5FRK3.23119526
6TRIM282.90824656
7MAP2K22.47964210
8RPS6KA42.42536010
9IKBKB2.19663622
10TAOK12.14480731
11NEK62.06636547
12ZAK1.99038626
13BMPR1B1.93235516
14GRK11.92672141
15NTRK21.91552041
16TXK1.86481847
17BRD41.84322137
18CHUK1.82245822
19PRKD31.78883290
20IRAK41.69130339
21MAP2K71.67223398
22WNK41.55084004
23ADRBK11.54917525
24WNK31.54208736
25STK38L1.48204814
26MAPK131.48055291
27TNK21.43104572
28MAP3K41.33534252
29PRKCI1.28827076
30FLT31.28515153
31MAP3K21.27053331
32EPHA41.25566712
33CASK1.23122400
34PRKCQ1.18702978
35LATS11.15424785
36MARK31.12504035
37FGFR21.10317316
38IKBKE1.09216812
39WNK11.04282521
40INSRR1.01389954
41MAP4K10.97213564
42KIT0.91355423
43PLK40.90909731
44GRK50.87288840
45MAP3K60.85584704
46EPHB20.85553641
47GRK60.79383195
48GRK70.75246286
49TGFBR10.73403480
50PNCK0.72919845
51MAP2K10.72855397
52RPS6KA50.72045640
53PKN20.69352606
54LIMK10.66254410
55STK240.66110147
56PKN10.65821370
57TLK10.65220369
58DAPK20.64029557
59NEK20.62951416
60PIK3CG0.62859263
61MAP4K20.62090395
62CDK70.62045666
63DYRK1B0.57024049
64DYRK20.54761611
65ITK0.52832848
66MAP2K40.50344503
67PRKCG0.49127851
68KDR0.47653785
69PRKD10.46844727
70TBK10.46458495
71MKNK20.46402972
72ACVR1B0.46203434
73ERBB20.43518065
74BTK0.42299492
75FER0.41537727
76OXSR10.39651107
77PRKD20.38843250
78LYN0.38518404
79GSK3A0.38160491
80TEC0.35451709
81RPS6KA10.35225810
82STK380.34460466
83DYRK1A0.34044780
84CAMK2D0.33777364
85SYK0.32722249
86CDK190.32452952
87EPHA30.32443082
88STK110.31713558
89PRKCZ0.28408375
90MATK0.28305235
91PIM10.28150710
92PRKAA20.27639902
93CAMK10.26858520
94PRKCH0.26080176
95PRKACA0.25376584
96PRKCA0.21558659
97STK390.20777808
98CDK80.19786095
99RPS6KA20.19046262
100CSNK1A10.18642963

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.09885335
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.07179225
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.74586977
4Basal transcription factors_Homo sapiens_hsa030222.68223211
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.58723810
6Fanconi anemia pathway_Homo sapiens_hsa034602.44843346
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.43358237
8Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.35958467
9Carbohydrate digestion and absorption_Homo sapiens_hsa049732.26655004
10Peroxisome_Homo sapiens_hsa041462.19823148
11Nitrogen metabolism_Homo sapiens_hsa009102.17332455
12Cardiac muscle contraction_Homo sapiens_hsa042601.99709793
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.96113532
14Cysteine and methionine metabolism_Homo sapiens_hsa002701.91222398
15Phototransduction_Homo sapiens_hsa047441.90870525
16SNARE interactions in vesicular transport_Homo sapiens_hsa041301.84027568
17Butanoate metabolism_Homo sapiens_hsa006501.71497699
18Histidine metabolism_Homo sapiens_hsa003401.68454866
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.66025148
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.61964888
21Insulin secretion_Homo sapiens_hsa049111.57743877
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.57479897
23Asthma_Homo sapiens_hsa053101.49516366
24Malaria_Homo sapiens_hsa051441.48976672
25Axon guidance_Homo sapiens_hsa043601.47439410
26Dorso-ventral axis formation_Homo sapiens_hsa043201.44552008
27Linoleic acid metabolism_Homo sapiens_hsa005911.44007268
28Taste transduction_Homo sapiens_hsa047421.41038480
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.34168277
30Nicotine addiction_Homo sapiens_hsa050331.30791228
31Olfactory transduction_Homo sapiens_hsa047401.29628207
32Mineral absorption_Homo sapiens_hsa049781.28854920
33ABC transporters_Homo sapiens_hsa020101.26013399
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.22570872
35Type II diabetes mellitus_Homo sapiens_hsa049301.16623744
36Glycerophospholipid metabolism_Homo sapiens_hsa005641.15623903
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.13451729
38Chemical carcinogenesis_Homo sapiens_hsa052041.05327195
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05252002
40Ovarian steroidogenesis_Homo sapiens_hsa049131.00320700
41Gastric acid secretion_Homo sapiens_hsa049711.00104213
42Salivary secretion_Homo sapiens_hsa049700.99441031
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.99369451
44Steroid biosynthesis_Homo sapiens_hsa001000.97961547
45Tryptophan metabolism_Homo sapiens_hsa003800.97345851
46Propanoate metabolism_Homo sapiens_hsa006400.96557902
47Sphingolipid metabolism_Homo sapiens_hsa006000.94548549
48Caffeine metabolism_Homo sapiens_hsa002320.91609966
49Primary immunodeficiency_Homo sapiens_hsa053400.88652716
50Bile secretion_Homo sapiens_hsa049760.87520967
51Arginine and proline metabolism_Homo sapiens_hsa003300.87150963
52Pancreatic secretion_Homo sapiens_hsa049720.83952111
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.83593829
54Circadian rhythm_Homo sapiens_hsa047100.82246215
55Circadian entrainment_Homo sapiens_hsa047130.78795830
56Oxidative phosphorylation_Homo sapiens_hsa001900.77243377
57cAMP signaling pathway_Homo sapiens_hsa040240.76060866
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75237446
59Retinol metabolism_Homo sapiens_hsa008300.74540719
60Parkinsons disease_Homo sapiens_hsa050120.72937212
61Arachidonic acid metabolism_Homo sapiens_hsa005900.67294172
62Serotonergic synapse_Homo sapiens_hsa047260.67205280
63Thyroid hormone synthesis_Homo sapiens_hsa049180.66825941
64Type I diabetes mellitus_Homo sapiens_hsa049400.64695960
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63228163
66Calcium signaling pathway_Homo sapiens_hsa040200.63149322
67p53 signaling pathway_Homo sapiens_hsa041150.62566502
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61855021
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60954724
70RNA degradation_Homo sapiens_hsa030180.60507565
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.59992636
72Pyruvate metabolism_Homo sapiens_hsa006200.58952264
73N-Glycan biosynthesis_Homo sapiens_hsa005100.54150364
74Renin secretion_Homo sapiens_hsa049240.53761530
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52878735
76Cholinergic synapse_Homo sapiens_hsa047250.52305830
77Homologous recombination_Homo sapiens_hsa034400.50793719
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49305832
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.48579031
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.48438488
81Nucleotide excision repair_Homo sapiens_hsa034200.48058051
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48029940
83Huntingtons disease_Homo sapiens_hsa050160.47920349
84Fatty acid metabolism_Homo sapiens_hsa012120.47556308
85Graft-versus-host disease_Homo sapiens_hsa053320.45865562
86Glycerolipid metabolism_Homo sapiens_hsa005610.43560526
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42455900
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41664780
89Metabolic pathways_Homo sapiens_hsa011000.40727682
90Dopaminergic synapse_Homo sapiens_hsa047280.38968611
91Hedgehog signaling pathway_Homo sapiens_hsa043400.38153932
92Protein digestion and absorption_Homo sapiens_hsa049740.38043972
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35290734
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34109028
95Sulfur relay system_Homo sapiens_hsa041220.33692803
96T cell receptor signaling pathway_Homo sapiens_hsa046600.33160807
97Glutamatergic synapse_Homo sapiens_hsa047240.33108261
98Oxytocin signaling pathway_Homo sapiens_hsa049210.32769556
99Other glycan degradation_Homo sapiens_hsa005110.32223993
100Collecting duct acid secretion_Homo sapiens_hsa049660.31359771

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