YWHAG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.34716757
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.01904273
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.67521810
4locomotory exploration behavior (GO:0035641)5.62701907
5synaptic vesicle exocytosis (GO:0016079)5.43690669
6glutamate secretion (GO:0014047)5.41143950
7layer formation in cerebral cortex (GO:0021819)5.32484539
8vocalization behavior (GO:0071625)5.28317998
9regulation of synaptic vesicle exocytosis (GO:2000300)5.05532033
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.01878035
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.96990944
12protein localization to synapse (GO:0035418)4.78237270
13proline transport (GO:0015824)4.74689463
14exploration behavior (GO:0035640)4.71390709
15neuron cell-cell adhesion (GO:0007158)4.67542582
16regulation of glutamate receptor signaling pathway (GO:1900449)4.64676053
17cerebellar granule cell differentiation (GO:0021707)4.62490735
18synaptic vesicle docking involved in exocytosis (GO:0016081)4.53643223
19regulation of synaptic vesicle transport (GO:1902803)4.45889807
20neurotransmitter secretion (GO:0007269)4.41269141
21regulation of synapse structural plasticity (GO:0051823)4.26705384
22regulation of neuronal synaptic plasticity (GO:0048168)4.15921829
23regulation of long-term neuronal synaptic plasticity (GO:0048169)4.14751641
24dendritic spine morphogenesis (GO:0060997)4.14338106
25cytoskeletal anchoring at plasma membrane (GO:0007016)4.05805247
26ionotropic glutamate receptor signaling pathway (GO:0035235)4.02908627
27cell migration in hindbrain (GO:0021535)3.99291001
28activation of protein kinase A activity (GO:0034199)3.93883065
29neuronal action potential propagation (GO:0019227)3.90280554
30gamma-aminobutyric acid transport (GO:0015812)3.86726869
31potassium ion homeostasis (GO:0055075)3.84828621
32neuron recognition (GO:0008038)3.83908976
33negative regulation of dendrite morphogenesis (GO:0050774)3.82165834
34negative regulation of microtubule polymerization (GO:0031115)3.76863970
35cellular sodium ion homeostasis (GO:0006883)3.74227065
36sodium ion export (GO:0071436)3.73663362
37cellular potassium ion homeostasis (GO:0030007)3.70905726
38dendrite morphogenesis (GO:0048813)3.70777157
39regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.67440055
40positive regulation of synapse maturation (GO:0090129)3.64582802
41amino acid import (GO:0043090)3.63686370
42positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.58599360
43axonal fasciculation (GO:0007413)3.58523969
44L-amino acid import (GO:0043092)3.57006086
45neuromuscular process controlling balance (GO:0050885)3.57001680
46glutamate receptor signaling pathway (GO:0007215)3.56906973
47cell communication involved in cardiac conduction (GO:0086065)3.54233434
48synaptic transmission, glutamatergic (GO:0035249)3.53133553
49neurotransmitter transport (GO:0006836)3.52175346
50positive regulation of dendritic spine morphogenesis (GO:0061003)3.51468835
51cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.51071664
52organelle transport along microtubule (GO:0072384)3.50892922
53neuronal ion channel clustering (GO:0045161)3.48520223
54synaptic vesicle endocytosis (GO:0048488)3.46998754
55cell communication by electrical coupling (GO:0010644)3.46713101
56vesicle transport along microtubule (GO:0047496)3.46323330
57axon cargo transport (GO:0008088)3.42170944
58mitochondrion transport along microtubule (GO:0047497)3.40540618
59establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.40540618
60pyrimidine nucleobase catabolic process (GO:0006208)3.39166343
61neurotransmitter-gated ion channel clustering (GO:0072578)3.37043109
62neuron-neuron synaptic transmission (GO:0007270)3.34965274
63potassium ion import (GO:0010107)3.33965240
64regulation of dendritic spine morphogenesis (GO:0061001)3.32091926
65long-term memory (GO:0007616)3.30550817
66postsynaptic membrane organization (GO:0001941)3.29466274
67regulation of excitatory postsynaptic membrane potential (GO:0060079)3.27259088
68positive regulation of membrane potential (GO:0045838)3.25796246
69regulation of neurotransmitter levels (GO:0001505)3.24544078
70cerebellar Purkinje cell differentiation (GO:0021702)3.21484264
71positive regulation of synaptic transmission, GABAergic (GO:0032230)3.21302561
72regulation of neurotransmitter secretion (GO:0046928)3.21056636
73establishment of mitochondrion localization (GO:0051654)3.19490540
74glycine transport (GO:0015816)3.17654877
75innervation (GO:0060384)3.16639431
76membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.16039975
77clathrin coat assembly (GO:0048268)3.15866669
78regulation of postsynaptic membrane potential (GO:0060078)3.15232184
79regulation of vesicle fusion (GO:0031338)3.15091738
80* regulation of synaptic plasticity (GO:0048167)3.14530242
81regulation of cAMP-dependent protein kinase activity (GO:2000479)3.12389209
82regulation of synapse maturation (GO:0090128)3.09263527
83regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.08763667
84transmission of nerve impulse (GO:0019226)3.04984014
85neuromuscular process controlling posture (GO:0050884)3.03849002
86nucleobase catabolic process (GO:0046113)3.03284203
87G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.02630380
88synapse assembly (GO:0007416)3.02507276
89response to auditory stimulus (GO:0010996)3.02131625
90axon extension (GO:0048675)3.01449326
91membrane depolarization during action potential (GO:0086010)3.01242832
92central nervous system projection neuron axonogenesis (GO:0021952)3.00216701
93auditory behavior (GO:0031223)2.99413980
94cerebellar Purkinje cell layer development (GO:0021680)2.99304120
95gamma-aminobutyric acid signaling pathway (GO:0007214)2.98511242
96intraspecies interaction between organisms (GO:0051703)2.98325508
97social behavior (GO:0035176)2.98325508
98mating behavior (GO:0007617)2.96875577
99positive regulation of neurotransmitter secretion (GO:0001956)2.94914559
100neuromuscular process (GO:0050905)2.94615582
101negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.94137738
102positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.93794510
103regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.93758642
104positive regulation of neurotransmitter transport (GO:0051590)2.92605254
105positive regulation of axon extension (GO:0045773)2.91974227
106regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.91551718
107regulation of neurotransmitter transport (GO:0051588)2.89773545
108regulation of synaptic transmission, glutamatergic (GO:0051966)2.88740049
109positive regulation of dendritic spine development (GO:0060999)2.88321496
110regulation of ARF protein signal transduction (GO:0032012)2.87341150
111dendritic spine organization (GO:0097061)2.86362897
112positive regulation of potassium ion transmembrane transport (GO:1901381)2.86302897
113negative regulation of synaptic transmission, GABAergic (GO:0032229)2.85191331
114regulation of dendritic spine development (GO:0060998)2.84276648
115alanine transport (GO:0032328)2.84273945
116regulation of voltage-gated calcium channel activity (GO:1901385)2.83397982
117positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.72540404
118dopamine receptor signaling pathway (GO:0007212)2.72309531
119adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.66376655
120suckling behavior (GO:0001967)2.61870922
121regulation of early endosome to late endosome transport (GO:2000641)2.60854586
122membrane depolarization (GO:0051899)2.59663336
123regulation of dendrite morphogenesis (GO:0048814)2.59310016
124regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.58911743
125positive regulation of dendrite development (GO:1900006)2.56323547
126* regulation of synaptic transmission (GO:0050804)2.55814156
127protein localization to endosome (GO:0036010)2.54285333
128presynaptic membrane organization (GO:0097090)2.52280017

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.91980853
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.06028687
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.00039981
4GBX2_23144817_ChIP-Seq_PC3_Human2.96376399
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.91402641
6REST_21632747_ChIP-Seq_MESCs_Mouse2.81987951
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.73156619
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.73156619
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.61178499
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59921929
11SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50213685
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.49910914
13DROSHA_22980978_ChIP-Seq_HELA_Human2.47580313
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46631095
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.42386293
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.40238379
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.39489731
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38803219
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.37850489
20* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.32809829
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.30569192
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.21463978
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17724573
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.17585959
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.16815922
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.14746108
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.09452214
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.03894633
29EED_16625203_ChIP-ChIP_MESCs_Mouse2.01476746
30AR_21572438_ChIP-Seq_LNCaP_Human1.94230396
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.90670481
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.82580858
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71321326
34* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.70192107
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.68827193
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.65101239
37ZNF274_21170338_ChIP-Seq_K562_Hela1.62248728
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61711072
39CLOCK_20551151_ChIP-Seq_293T_Human1.57241816
40WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.50465557
41TRIM28_21343339_ChIP-Seq_HEK293_Human1.50165259
42KDM2B_26808549_Chip-Seq_K562_Human1.48742146
43NR3C1_23031785_ChIP-Seq_PC12_Mouse1.47182721
44SMAD4_21799915_ChIP-Seq_A2780_Human1.46518073
45* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.44987756
46RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.44593131
47EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44325487
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43650012
49* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.43068293
50RING1B_27294783_Chip-Seq_ESCs_Mouse1.39189762
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.39128605
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37953855
53SOX2_21211035_ChIP-Seq_LN229_Gbm1.36965658
54* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33289181
55TAF15_26573619_Chip-Seq_HEK293_Human1.31793675
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28555226
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27037472
58P300_27058665_Chip-Seq_ZR-75-30cells_Human1.26081299
59AR_19668381_ChIP-Seq_PC3_Human1.25758168
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25750911
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24516295
62LXR_22292898_ChIP-Seq_THP-1_Human1.23024014
63RING1B_27294783_Chip-Seq_NPCs_Mouse1.22042834
64CTNNB1_20460455_ChIP-Seq_HCT116_Human1.17578564
65KDM2B_26808549_Chip-Seq_DND41_Human1.17450890
66GATA1_26923725_Chip-Seq_HPCs_Mouse1.17243693
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.16575149
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15092581
69AR_25329375_ChIP-Seq_VCAP_Human1.13090622
70* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12140490
71UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11843333
72STAT3_23295773_ChIP-Seq_U87_Human1.10753392
73SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09186344
74PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08908407
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08861300
76* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08322583
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07763539
78RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07172875
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06532246
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.06378474
81AHR_22903824_ChIP-Seq_MCF-7_Human1.04912243
82* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04827940
83GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04343612
84KDM2B_26808549_Chip-Seq_JURKAT_Human1.04214721
85P300_19829295_ChIP-Seq_ESCs_Human1.03736559
86KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03035586
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02994217
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.02750049
89WT1_19549856_ChIP-ChIP_CCG9911_Human1.02453539
90RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02163557
91P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01701735
92NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01317453
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00737079
94* TET1_21490601_ChIP-Seq_MESCs_Mouse1.00555650
95RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00525096
96SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00468334
97IGF1R_20145208_ChIP-Seq_DFB_Human1.00343639
98SMAD3_21741376_ChIP-Seq_ESCs_Human0.99705640
99* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99305595
100* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97750872
101ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97393348
102CREB1_26743006_Chip-Seq_LNCaP_Human0.97262965
103SMAD4_21741376_ChIP-Seq_HESCs_Human0.97209398
104GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.95973621
105KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95648154
106RUNX1_26923725_Chip-Seq_HPCs_Mouse0.95421191
107TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94785768
108CTCF_27219007_Chip-Seq_Bcells_Human0.92038074
109TCF4_23295773_ChIP-Seq_U87_Human0.90958157
110OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.90437656
111TCF7_22412390_ChIP-Seq_EML_Mouse0.90085350
112DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89859354
113BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89215869
114DPY_21335234_ChIP-Seq_ESCs_Mouse0.89214181
115ISL1_27105846_Chip-Seq_CPCs_Mouse0.89155743
116RNF2_27304074_Chip-Seq_NSC_Mouse0.88327065
117* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.88308059
118MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88304872
119CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88222219
120RACK7_27058665_Chip-Seq_MCF-7_Human0.87906346
121EP300_21415370_ChIP-Seq_HL-1_Mouse0.87825012
122PIAS1_25552417_ChIP-Seq_VCAP_Human0.87283697
123ZFP57_27257070_Chip-Seq_ESCs_Mouse0.86763730
124TP53_16413492_ChIP-PET_HCT116_Human0.86648953
125AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85844800
126ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85680350
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.85484184
128CBX2_27304074_Chip-Seq_ESCs_Mouse0.85336259
129TP53_20018659_ChIP-ChIP_R1E_Mouse0.85037772
130ZNF263_19887448_ChIP-Seq_K562_Human0.84373234
131PRDM14_20953172_ChIP-Seq_ESCs_Human0.83040696
132JUN_21703547_ChIP-Seq_K562_Human0.82625212
133* TP53_23651856_ChIP-Seq_MEFs_Mouse0.82590084
134SMAD3_21741376_ChIP-Seq_HESCs_Human0.82577232
135POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.81415834
136* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.80766206
137* NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.79865845
138NFIB_24661679_ChIP-Seq_LUNG_Mouse0.79328264
139MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.78966627

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.52293823
2MP0003880_abnormal_central_pattern4.31368545
3MP0004270_analgesia4.20256766
4MP0003635_abnormal_synaptic_transmissio4.04364726
5MP0001968_abnormal_touch/_nociception3.26528051
6MP0002063_abnormal_learning/memory/cond3.21681955
7MP0009745_abnormal_behavioral_response3.08049824
8MP0002734_abnormal_mechanical_nocicepti2.95076329
9MP0005423_abnormal_somatic_nervous2.91183780
10MP0002064_seizures2.87811358
11MP0002735_abnormal_chemical_nociception2.83596645
12MP0009046_muscle_twitch2.81537288
13MP0004858_abnormal_nervous_system2.71565787
14MP0002572_abnormal_emotion/affect_behav2.55792023
15MP0002733_abnormal_thermal_nociception2.55677866
16MP0002736_abnormal_nociception_after2.47082079
17MP0003329_amyloid_beta_deposits2.36098307
18MP0002272_abnormal_nervous_system2.24114116
19MP0001486_abnormal_startle_reflex2.19938391
20MP0001970_abnormal_pain_threshold2.19424998
21MP0001440_abnormal_grooming_behavior2.19103299
22MP0009780_abnormal_chondrocyte_physiolo2.15647058
23MP0000778_abnormal_nervous_system2.14180981
24MP0006276_abnormal_autonomic_nervous2.12850350
25MP0003705_abnormal_hypodermis_morpholog2.09670811
26MP0004811_abnormal_neuron_physiology2.06417917
27MP0002184_abnormal_innervation2.05842596
28MP0001501_abnormal_sleep_pattern1.96703197
29MP0002909_abnormal_adrenal_gland1.89636547
30MP0002067_abnormal_sensory_capabilities1.87948665
31MP0000955_abnormal_spinal_cord1.81528207
32MP0005409_darkened_coat_color1.76317468
33MP0004924_abnormal_behavior1.75666503
34MP0005386_behavior/neurological_phenoty1.75666503
35MP0008569_lethality_at_weaning1.71503143
36MP0002557_abnormal_social/conspecific_i1.65711922
37MP0000579_abnormal_nail_morphology1.65404471
38MP0002822_catalepsy1.56214660
39MP0000569_abnormal_digit_pigmentation1.51424914
40MP0002882_abnormal_neuron_morphology1.46947507
41MP0002066_abnormal_motor_capabilities/c1.43201630
42MP0004885_abnormal_endolymph1.37243859
43MP0000751_myopathy1.31128792
44MP0003122_maternal_imprinting1.30870983
45MP0003879_abnormal_hair_cell1.29880708
46MP0003633_abnormal_nervous_system1.25667878
47MP0001348_abnormal_lacrimal_gland1.21488120
48MP0002152_abnormal_brain_morphology1.19413076
49MP0008961_abnormal_basal_metabolism1.13161722
50MP0002877_abnormal_melanocyte_morpholog1.12794380
51MP0000604_amyloidosis1.12495405
52MP0005645_abnormal_hypothalamus_physiol1.10717913
53MP0003631_nervous_system_phenotype1.09537099
54MP0001984_abnormal_olfaction1.08560873
55MP0003787_abnormal_imprinting1.07882305
56MP0005623_abnormal_meninges_morphology1.07125625
57MP0004142_abnormal_muscle_tone1.05782153
58MP0002837_dystrophic_cardiac_calcinosis1.05734207
59MP0003283_abnormal_digestive_organ1.05412663
60MP0001905_abnormal_dopamine_level1.02752323
61MP0009672_abnormal_birth_weight1.02569915
62MP0004145_abnormal_muscle_electrophysio0.99286862
63MP0004233_abnormal_muscle_weight0.98355211
64MP0001529_abnormal_vocalization0.97304151
65MP0000537_abnormal_urethra_morphology0.96910568
66MP0004185_abnormal_adipocyte_glucose0.94461868
67MP0003634_abnormal_glial_cell0.93885341
68MP0000013_abnormal_adipose_tissue0.93862004
69MP0004130_abnormal_muscle_cell0.93243968
70MP0001502_abnormal_circadian_rhythm0.93089903
71MP0005646_abnormal_pituitary_gland0.92599558
72MP0002229_neurodegeneration0.90036127
73MP0002069_abnormal_eating/drinking_beha0.88995359
74MP0001346_abnormal_lacrimal_gland0.86987413
75MP0001299_abnormal_eye_distance/0.84691827
76MP0003632_abnormal_nervous_system0.84319994
77MP0008872_abnormal_physiological_respon0.83015191
78MP0001849_ear_inflammation0.82473832
79MP0005535_abnormal_body_temperature0.80957354
80MP0004085_abnormal_heartbeat0.80729577
81MP0008874_decreased_physiological_sensi0.80651801
82MP0005187_abnormal_penis_morphology0.77505519
83MP0003861_abnormal_nervous_system0.76934234
84MP0000534_abnormal_ureter_morphology0.75205558
85MP0002081_perinatal_lethality0.74757034
86MP0002752_abnormal_somatic_nervous0.74421043
87MP0004087_abnormal_muscle_fiber0.74318177
88MP0000759_abnormal_skeletal_muscle0.74166553
89MP0005394_taste/olfaction_phenotype0.74036849
90MP0005499_abnormal_olfactory_system0.74036849
91MP0003566_abnormal_cell_adhesion0.73884623
92MP0003172_abnormal_lysosome_physiology0.73756373
93MP0005666_abnormal_adipose_tissue0.73674007
94MP0010234_abnormal_vibrissa_follicle0.72638335
95MP0002089_abnormal_postnatal_growth/wei0.70633782
96MP0004484_altered_response_of0.69865228
97MP0000747_muscle_weakness0.69789546
98MP0001177_atelectasis0.68699798
99MP0003137_abnormal_impulse_conducting0.68565073
100MP0003091_abnormal_cell_migration0.68022421
101MP0005076_abnormal_cell_differentiation0.67379089
102MP0003385_abnormal_body_wall0.66128796
103MP0010768_mortality/aging0.66095410
104MP0000566_synostosis0.65401849
105MP0004742_abnormal_vestibular_system0.65151222
106MP0003690_abnormal_glial_cell0.64664674
107MP0004215_abnormal_myocardial_fiber0.63196658
108MP0003123_paternal_imprinting0.62866944
109MP0001188_hyperpigmentation0.62130051
110MP0003075_altered_response_to0.61327718
111MP0001963_abnormal_hearing_physiology0.60105364
112MP0004510_myositis0.59842172
113MP0000733_abnormal_muscle_development0.59199283
114MP0005375_adipose_tissue_phenotype0.57751078
115MP0000920_abnormal_myelination0.57523498
116MP0010769_abnormal_survival0.56745983
117MP0002090_abnormal_vision0.56584548
118MP0000631_abnormal_neuroendocrine_gland0.56378863
119MP0001943_abnormal_respiration0.56356441
120MP0010386_abnormal_urinary_bladder0.55995816
121MP0002751_abnormal_autonomic_nervous0.55853154
122MP0010770_preweaning_lethality0.54306625
123MP0002082_postnatal_lethality0.54306625
124MP0003956_abnormal_body_size0.52686283
125MP0006138_congestive_heart_failure0.52369209

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.23572479
2Focal motor seizures (HP:0011153)5.63141783
3Visual hallucinations (HP:0002367)5.17209046
4Focal seizures (HP:0007359)4.99579537
5Supranuclear gaze palsy (HP:0000605)4.45392077
6Mutism (HP:0002300)4.02843550
7Action tremor (HP:0002345)3.84392283
8Epileptic encephalopathy (HP:0200134)3.83200819
9Progressive cerebellar ataxia (HP:0002073)3.75716642
10Papilledema (HP:0001085)3.70175488
11Ankle clonus (HP:0011448)3.68836419
12Atonic seizures (HP:0010819)3.59937928
13Absence seizures (HP:0002121)3.43919321
14Termporal pattern (HP:0011008)3.36549653
15Insidious onset (HP:0003587)3.36549653
16Generalized tonic-clonic seizures (HP:0002069)3.32617547
17Febrile seizures (HP:0002373)3.26367630
18Cerebral inclusion bodies (HP:0100314)3.22534652
19Urinary bladder sphincter dysfunction (HP:0002839)3.17384965
20Abnormality of the lower motor neuron (HP:0002366)3.14352954
21Poor eye contact (HP:0000817)3.12872978
22Amyotrophic lateral sclerosis (HP:0007354)3.12638793
23Hyperacusis (HP:0010780)3.12431376
24Dialeptic seizures (HP:0011146)3.09020949
25Urinary urgency (HP:0000012)3.01158464
26Depression (HP:0000716)2.99024300
27Impaired vibration sensation in the lower limbs (HP:0002166)2.98724898
28Neurofibrillary tangles (HP:0002185)2.95924290
29Limb dystonia (HP:0002451)2.95896920
30Abnormality of the corticospinal tract (HP:0002492)2.88354333
31Abnormal social behavior (HP:0012433)2.87686275
32Impaired social interactions (HP:0000735)2.87686275
33Abnormal eating behavior (HP:0100738)2.86040587
34Broad-based gait (HP:0002136)2.84485850
35Amblyopia (HP:0000646)2.75216175
36Truncal ataxia (HP:0002078)2.73266932
37Postural instability (HP:0002172)2.73133997
38Pheochromocytoma (HP:0002666)2.72869852
39Genetic anticipation (HP:0003743)2.67990529
40Excessive salivation (HP:0003781)2.64284107
41Drooling (HP:0002307)2.64284107
42Diplopia (HP:0000651)2.59176265
43Abnormality of binocular vision (HP:0011514)2.59176265
44Dysdiadochokinesis (HP:0002075)2.57367965
45Spastic gait (HP:0002064)2.56348932
46Progressive inability to walk (HP:0002505)2.55434494
47Torticollis (HP:0000473)2.55303002
48Dysmetria (HP:0001310)2.50651286
49Anxiety (HP:0000739)2.49839652
50Apathy (HP:0000741)2.49579627
51Insomnia (HP:0100785)2.46157040
52Polyphagia (HP:0002591)2.43415451
53Akinesia (HP:0002304)2.42252149
54Overriding aorta (HP:0002623)2.39893574
55Agitation (HP:0000713)2.38853952
56Bradykinesia (HP:0002067)2.38832444
57Inappropriate behavior (HP:0000719)2.38421414
58Lower limb muscle weakness (HP:0007340)2.34513272
59Tetraplegia (HP:0002445)2.34053742
60Gaze-evoked nystagmus (HP:0000640)2.32501075
61Hemiparesis (HP:0001269)2.30261269
62Neuroendocrine neoplasm (HP:0100634)2.29757939
63Focal dystonia (HP:0004373)2.28546802
64Elfin facies (HP:0004428)2.28197078
65Annular pancreas (HP:0001734)2.26790520
66Rapidly progressive (HP:0003678)2.25665943
67Impaired smooth pursuit (HP:0007772)2.25567422
68Megalencephaly (HP:0001355)2.24113613
69Fetal akinesia sequence (HP:0001989)2.22875598
70EEG with generalized epileptiform discharges (HP:0011198)2.22544367
71Ulnar claw (HP:0001178)2.22401340
72Epileptiform EEG discharges (HP:0011182)2.21449382
73Diminished motivation (HP:0000745)2.20733217
74Stereotypic behavior (HP:0000733)2.19053609
75Hypsarrhythmia (HP:0002521)2.18004318
76Hyperventilation (HP:0002883)2.16842907
77Obstructive sleep apnea (HP:0002870)2.15861040
78Pointed chin (HP:0000307)2.14644048
79Lower limb amyotrophy (HP:0007210)2.12768692
80Hemiplegia (HP:0002301)2.11953996
81Craniofacial dystonia (HP:0012179)2.10563309
82Intention tremor (HP:0002080)2.09850027
83Aplasia/Hypoplasia of the brainstem (HP:0007362)2.09591288
84Hypoplasia of the brainstem (HP:0002365)2.09591288
85Ventricular fibrillation (HP:0001663)2.09246851
86Ankyloglossia (HP:0010296)2.08950331
87Neoplasm of the peripheral nervous system (HP:0100007)2.08121031
88Morphological abnormality of the pyramidal tract (HP:0002062)2.06215742
89Neuronal loss in central nervous system (HP:0002529)2.03180044
90Hypercortisolism (HP:0001578)1.99195926
91Abnormality of ocular smooth pursuit (HP:0000617)1.98904287
92Inability to walk (HP:0002540)1.98286995
93Hypoventilation (HP:0002791)1.97927141
94Hammertoe (HP:0001765)1.97806332
95Failure to thrive in infancy (HP:0001531)1.96684838
96Upper limb amyotrophy (HP:0009129)1.93769370
97Distal upper limb amyotrophy (HP:0007149)1.93769370
98Renal duplication (HP:0000075)1.93533853
99Absent speech (HP:0001344)1.92579912
100Distal lower limb amyotrophy (HP:0008944)1.92191820
101Turricephaly (HP:0000262)1.91978969
102Aqueductal stenosis (HP:0002410)1.90614837
103Aplasia involving bones of the upper limbs (HP:0009823)1.89490513
104Aplasia of the phalanges of the hand (HP:0009802)1.89490513
105Aplasia involving bones of the extremities (HP:0009825)1.89490513
106Bundle branch block (HP:0011710)1.89145588
107Dysmetric saccades (HP:0000641)1.88968140
108Shallow orbits (HP:0000586)1.88575539
109Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.88251250
110Clonus (HP:0002169)1.88117743
111Renovascular hypertension (HP:0100817)1.87370222
112Generalized myoclonic seizures (HP:0002123)1.86914112
113Foot dorsiflexor weakness (HP:0009027)1.86459036
114Peripheral hypomyelination (HP:0007182)1.86417051
115Rigidity (HP:0002063)1.85339690
116Scanning speech (HP:0002168)1.85185916
117Spastic tetraparesis (HP:0001285)1.84722960
118Impaired vibratory sensation (HP:0002495)1.84654118
119Decreased motor nerve conduction velocity (HP:0003431)1.84575478
120Distal sensory impairment (HP:0002936)1.83158352
121Abnormality of pain sensation (HP:0010832)1.82093396
122Impaired pain sensation (HP:0007328)1.82093396
123Status epilepticus (HP:0002133)1.81864555
124Lower limb asymmetry (HP:0100559)1.80238169
125Bronchomalacia (HP:0002780)1.79791305
126Bowel diverticulosis (HP:0005222)1.77665034
127Abnormality of the foot musculature (HP:0001436)1.75777313
128Hand muscle atrophy (HP:0009130)1.74984354
129Bowel incontinence (HP:0002607)1.71178299
130Hyporeflexia of lower limbs (HP:0002600)1.71049637
131Achilles tendon contracture (HP:0001771)1.68702948
132Sleep apnea (HP:0010535)1.66795325
133Arnold-Chiari malformation (HP:0002308)1.65889656

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.90061259
2MAP3K94.78421399
3NTRK33.93881624
4MINK13.30317916
5MAP3K42.99958717
6EPHA42.57753897
7PAK62.49884607
8KSR22.42757870
9NTRK12.33956134
10MAP2K72.23202694
11DAPK22.07302390
12NTRK22.03391010
13MAP2K42.01890865
14PHKG21.89481380
15PHKG11.89481380
16EEF2K1.85648004
17MAP3K121.83877666
18CAMKK11.76537986
19KSR11.69654410
20PRKD31.63061270
21PNCK1.62542366
22CDK51.52585006
23PLK21.44138178
24SIK21.43075130
25CDK121.42147176
26MAPK131.41180869
27GRK51.39121221
28LMTK21.38997592
29RET1.29987173
30MAP3K21.28647661
31SCYL21.24536340
32TAOK11.20127656
33DAPK11.19105207
34STK381.18832174
35RIPK41.18171470
36ALK1.10870612
37UHMK11.09402916
38ARAF1.09137724
39TYRO31.07144419
40PRKCG1.05575074
41CDK141.04756993
42PAK31.01748886
43BRAF1.01286270
44CDK181.00150857
45CDK150.99682849
46CSNK1G20.97758781
47NEK10.89707454
48CDK11A0.87070902
49STK110.85318291
50MOS0.84071797
51LIMK10.83926140
52TTN0.83245075
53CDK190.80472089
54SMG10.78943700
55DYRK20.77445276
56PTK20.76846410
57CAMK2A0.76356516
58CAMKK20.76200694
59CAMK1D0.76123477
60TESK10.76009912
61MARK20.76005160
62CASK0.75020201
63RIPK10.73859330
64CAMK1G0.73363345
65FES0.73344307
66SGK20.73004394
67NEK60.72164491
68RAF10.71966646
69CAMK2G0.70819722
70PRKCH0.67808486
71CAMK10.62797254
72DYRK1A0.61157251
73RPS6KA20.60441283
74SIK10.59790957
75PRKCZ0.59343697
76MAP3K130.59200225
77FER0.58044813
78MAP2K10.57104136
79MTOR0.57068228
80PAK20.56976151
81TRIB30.56338702
82PRPF4B0.54290541
83MAP3K60.54225468
84MAP3K10.53320806
85ERBB30.53134328
86PKN20.50810194
87TNIK0.50286575
88PTK2B0.49728446
89PDK10.49551471
90PDPK10.47094341
91MAPK100.45981476
92FYN0.45802846
93BRD40.45677377
94SGK10.45570470
95RPS6KA30.44007552
96SGK2230.43776326
97SGK4940.43776326
98TSSK60.43733760
99CAMK40.42519075
100CAMK2D0.42500961
101DMPK0.41688124
102CSNK1G30.41106412
103CDC42BPA0.40482338
104BRSK10.40317098
105CAMK2B0.40297449
106PDGFRA0.40164578
107MAPK120.38966402
108WNK10.38308859
109PRKCE0.37272704
110RPS6KB10.36935635
111AKT20.36882760
112MAP2K60.36244355
113SGK30.35764622
114MAPKAPK50.35415490
115ICK0.34694147
116CSNK1E0.34537635
117PDK30.33455918
118PDK40.33455918
119FGR0.33309547
120GSK3B0.32798683
121PDGFRB0.32503671
122ROCK20.31548201
123DDR20.30647962
124MAPK80.29945878

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.30262383
2Nicotine addiction_Homo sapiens_hsa050333.05486068
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.57564348
4Long-term potentiation_Homo sapiens_hsa047202.48745668
5Olfactory transduction_Homo sapiens_hsa047402.42611500
6Circadian entrainment_Homo sapiens_hsa047132.37703439
7GABAergic synapse_Homo sapiens_hsa047272.36370775
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.27872105
9Glutamatergic synapse_Homo sapiens_hsa047242.20836818
10Dopaminergic synapse_Homo sapiens_hsa047282.12896115
11Amphetamine addiction_Homo sapiens_hsa050312.10854696
12Morphine addiction_Homo sapiens_hsa050322.05457135
13Salivary secretion_Homo sapiens_hsa049701.94362150
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.91713339
15Cholinergic synapse_Homo sapiens_hsa047251.84501336
16Gastric acid secretion_Homo sapiens_hsa049711.78789946
17Insulin secretion_Homo sapiens_hsa049111.77388995
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.76706924
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.67766714
20Long-term depression_Homo sapiens_hsa047301.59398340
21Oxytocin signaling pathway_Homo sapiens_hsa049211.59390710
22Renin secretion_Homo sapiens_hsa049241.58085183
23GnRH signaling pathway_Homo sapiens_hsa049121.52943787
24Gap junction_Homo sapiens_hsa045401.51936745
25Taste transduction_Homo sapiens_hsa047421.51436730
26Serotonergic synapse_Homo sapiens_hsa047261.48195479
27Cocaine addiction_Homo sapiens_hsa050301.47098802
28Glioma_Homo sapiens_hsa052141.40404366
29Vitamin B6 metabolism_Homo sapiens_hsa007501.40084334
30Estrogen signaling pathway_Homo sapiens_hsa049151.37818792
31Axon guidance_Homo sapiens_hsa043601.37137086
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36988025
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.36108761
34Calcium signaling pathway_Homo sapiens_hsa040201.29745101
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29694951
36Type II diabetes mellitus_Homo sapiens_hsa049301.24878823
37ErbB signaling pathway_Homo sapiens_hsa040121.21498394
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13631585
39Collecting duct acid secretion_Homo sapiens_hsa049661.12518414
40Melanogenesis_Homo sapiens_hsa049161.11855236
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.10665060
42cAMP signaling pathway_Homo sapiens_hsa040241.10595359
43Dorso-ventral axis formation_Homo sapiens_hsa043201.10137042
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.02880813
45Neurotrophin signaling pathway_Homo sapiens_hsa047221.02139368
46* Oocyte meiosis_Homo sapiens_hsa041141.01347753
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01076098
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94677184
49Cardiac muscle contraction_Homo sapiens_hsa042600.92829470
50VEGF signaling pathway_Homo sapiens_hsa043700.92202490
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91451528
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.89302263
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.89057632
54Endometrial cancer_Homo sapiens_hsa052130.87038441
55mTOR signaling pathway_Homo sapiens_hsa041500.85041619
56Vibrio cholerae infection_Homo sapiens_hsa051100.81487493
57Dilated cardiomyopathy_Homo sapiens_hsa054140.78870143
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.77843658
59Chronic myeloid leukemia_Homo sapiens_hsa052200.77434153
60MAPK signaling pathway_Homo sapiens_hsa040100.77321494
61Choline metabolism in cancer_Homo sapiens_hsa052310.76363388
62Insulin signaling pathway_Homo sapiens_hsa049100.75938549
63Adherens junction_Homo sapiens_hsa045200.74776833
64Nitrogen metabolism_Homo sapiens_hsa009100.73843070
65Renal cell carcinoma_Homo sapiens_hsa052110.72045170
66Glucagon signaling pathway_Homo sapiens_hsa049220.71167972
67Thyroid hormone synthesis_Homo sapiens_hsa049180.69870769
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69866399
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.68612931
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67729663
71Colorectal cancer_Homo sapiens_hsa052100.67242086
72Fatty acid biosynthesis_Homo sapiens_hsa000610.66739200
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66550447
74Endocytosis_Homo sapiens_hsa041440.66404879
75Thyroid cancer_Homo sapiens_hsa052160.65875822
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64264466
77Focal adhesion_Homo sapiens_hsa045100.64217358
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64015053
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63187107
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62021212
81Ras signaling pathway_Homo sapiens_hsa040140.61970394
82Pancreatic secretion_Homo sapiens_hsa049720.61624619
83Rap1 signaling pathway_Homo sapiens_hsa040150.61384560
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60704875
85Proteoglycans in cancer_Homo sapiens_hsa052050.59594373
86Non-small cell lung cancer_Homo sapiens_hsa052230.59326649
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59050535
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.58738974
89Prion diseases_Homo sapiens_hsa050200.58528529
90* Hippo signaling pathway_Homo sapiens_hsa043900.57165438
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55175201
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54706453
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53619427
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52989064
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51536328
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51385195
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51208564
98Wnt signaling pathway_Homo sapiens_hsa043100.50282440
99Amoebiasis_Homo sapiens_hsa051460.48817448
100MicroRNAs in cancer_Homo sapiens_hsa052060.47536788
101HIF-1 signaling pathway_Homo sapiens_hsa040660.47527809
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46899493
103Bile secretion_Homo sapiens_hsa049760.45607786
104Alcoholism_Homo sapiens_hsa050340.43318973
105Prolactin signaling pathway_Homo sapiens_hsa049170.41858142
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41425196
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40024925
108Inositol phosphate metabolism_Homo sapiens_hsa005620.38929383
109Phototransduction_Homo sapiens_hsa047440.38781662
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38766381
111AMPK signaling pathway_Homo sapiens_hsa041520.37758549
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.37434021
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36148992
114Tight junction_Homo sapiens_hsa045300.33193853
115Melanoma_Homo sapiens_hsa052180.32618585
116Chemokine signaling pathway_Homo sapiens_hsa040620.31383461

Most similar genes based on co-expression Upload to Enrichr

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