YWHAQ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)9.09018052
2axon ensheathment in central nervous system (GO:0032291)9.09018052
3pyrimidine nucleobase catabolic process (GO:0006208)5.73419173
4fatty acid elongation (GO:0030497)5.65384147
5myelination (GO:0042552)5.56532607
6axon ensheathment (GO:0008366)5.55335403
7ensheathment of neurons (GO:0007272)5.55335403
8long-chain fatty acid biosynthetic process (GO:0042759)4.83000847
9nucleobase catabolic process (GO:0046113)4.48552821
10positive regulation of mitochondrial fission (GO:0090141)4.44964817
11negative regulation of neurotransmitter secretion (GO:0046929)4.25090391
12cholesterol biosynthetic process (GO:0006695)4.19454775
13establishment of mitochondrion localization (GO:0051654)4.04223592
14apical protein localization (GO:0045176)4.02164055
15negative regulation of neurotransmitter transport (GO:0051589)3.97970074
16oligodendrocyte differentiation (GO:0048709)3.93597712
17protein neddylation (GO:0045116)3.91977770
18sequestering of actin monomers (GO:0042989)3.79437303
19* substantia nigra development (GO:0021762)3.75489687
20regulation of collateral sprouting (GO:0048670)3.72614600
21sterol biosynthetic process (GO:0016126)3.67678139
22positive regulation of oligodendrocyte differentiation (GO:0048714)3.61702308
23response to redox state (GO:0051775)3.58854081
24asymmetric protein localization (GO:0008105)3.51167730
25de novo posttranslational protein folding (GO:0051084)3.51066115
26glycerophospholipid catabolic process (GO:0046475)3.50180859
27limb bud formation (GO:0060174)3.47400283
28isoprenoid biosynthetic process (GO:0008299)3.44792962
29chaperone-mediated protein transport (GO:0072321)3.44395216
30myelin maintenance (GO:0043217)3.41029146
31de novo protein folding (GO:0006458)3.40564052
32astrocyte development (GO:0014002)3.36670226
33peptidyl-arginine omega-N-methylation (GO:0035247)3.34002595
34mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.33464162
35peptidyl-arginine methylation (GO:0018216)3.31616529
36peptidyl-arginine N-methylation (GO:0035246)3.31616529
37photoreceptor cell differentiation (GO:0046530)3.30162221
38eye photoreceptor cell differentiation (GO:0001754)3.30162221
39presynaptic membrane organization (GO:0097090)3.29374221
40neuron cell-cell adhesion (GO:0007158)3.25660889
41DNA damage response, detection of DNA damage (GO:0042769)3.17599397
42presynaptic membrane assembly (GO:0097105)3.13575239
43layer formation in cerebral cortex (GO:0021819)3.11686804
44microtubule polymerization or depolymerization (GO:0031109)3.11574536
45negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.09025136
46protein localization to synapse (GO:0035418)3.06871092
47energy coupled proton transport, down electrochemical gradient (GO:0015985)3.06500017
48ATP synthesis coupled proton transport (GO:0015986)3.06500017
49DNA double-strand break processing (GO:0000729)3.06327912
50mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.05275353
51negative regulation of axonogenesis (GO:0050771)3.05016767
52establishment of viral latency (GO:0019043)3.04920568
53negative regulation of protein localization to cell surface (GO:2000009)2.98446618
54transmission of nerve impulse (GO:0019226)2.98023061
55postsynaptic membrane organization (GO:0001941)2.96739305
56ribonucleoprotein complex disassembly (GO:0032988)2.95737479
57cerebral cortex radially oriented cell migration (GO:0021799)2.90670767
58vocalization behavior (GO:0071625)2.90289287
59L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.89151344
60synapse assembly (GO:0007416)2.86108954
61gamma-aminobutyric acid transport (GO:0015812)2.85921333
62magnesium ion transport (GO:0015693)2.84389914
63cullin deneddylation (GO:0010388)2.82986883
64negative regulation of JUN kinase activity (GO:0043508)2.82022533
65negative regulation of axon extension (GO:0030517)2.81983980
66peptidyl-cysteine modification (GO:0018198)2.79597391
67mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.79230058
68synaptic vesicle maturation (GO:0016188)2.76173364
69negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.75815237
70calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.75362309
71myelination in peripheral nervous system (GO:0022011)2.74917810
72peripheral nervous system axon ensheathment (GO:0032292)2.74917810
73* neural nucleus development (GO:0048857)2.74674310
74regulation of mitochondrial fission (GO:0090140)2.74260858
75microtubule depolymerization (GO:0007019)2.74049624
76histone arginine methylation (GO:0034969)2.73968947
77protein palmitoylation (GO:0018345)2.73634785
78histone H2B ubiquitination (GO:0033523)2.71450614
79negative regulation of synaptic transmission, GABAergic (GO:0032229)2.71327928
80synaptic vesicle exocytosis (GO:0016079)2.67789492
81organelle disassembly (GO:1903008)2.67176712
82histone H2A acetylation (GO:0043968)2.65548747
83positive regulation of actin filament depolymerization (GO:0030836)2.65256552
84glial cell development (GO:0021782)2.64123391
85regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.63986168
86regulation of short-term neuronal synaptic plasticity (GO:0048172)2.62213370
87long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.60779213
88adult walking behavior (GO:0007628)2.59768780
89regulation of synaptic vesicle exocytosis (GO:2000300)2.59504395
90positive regulation of synapse assembly (GO:0051965)2.59102462
91hippocampus development (GO:0021766)2.58971287
92GPI anchor biosynthetic process (GO:0006506)2.58404593
93adhesion of symbiont to host cell (GO:0044650)2.58033099
94virion attachment to host cell (GO:0019062)2.58033099
95regulation of development, heterochronic (GO:0040034)2.56934116
96protein insertion into membrane (GO:0051205)2.56567116
97glutamate secretion (GO:0014047)2.55759603
98auditory behavior (GO:0031223)2.54857964
99cytoskeleton-dependent intracellular transport (GO:0030705)2.54537169
100neuron recognition (GO:0008038)2.54233516
101negative regulation of microtubule polymerization (GO:0031115)2.53148251
102peptidyl-tyrosine autophosphorylation (GO:0038083)2.52667174
103protein localization to cilium (GO:0061512)2.52292326
104positive regulation of dendritic spine morphogenesis (GO:0061003)2.51615232
105preassembly of GPI anchor in ER membrane (GO:0016254)2.50882465
106glycosphingolipid biosynthetic process (GO:0006688)2.49226014
107negative regulation of oligodendrocyte differentiation (GO:0048715)2.48989317
108establishment of protein localization to mitochondrial membrane (GO:0090151)2.48824440
109neurofilament cytoskeleton organization (GO:0060052)2.48445193
110creatine metabolic process (GO:0006600)2.47981785
111dopamine biosynthetic process (GO:0042416)2.47505110
112protein deneddylation (GO:0000338)2.47270180
113nonmotile primary cilium assembly (GO:0035058)2.46560002
114regulation of synapse structural plasticity (GO:0051823)2.46194534
115mitotic nuclear envelope reassembly (GO:0007084)2.46109795
116nuclear envelope reassembly (GO:0031468)2.46109795
117neuronal ion channel clustering (GO:0045161)2.45217881
118establishment of integrated proviral latency (GO:0075713)2.43148219
119long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.42753590
120DNA ligation (GO:0006266)2.42711806
121neuronal action potential propagation (GO:0019227)2.42364138
122GPI anchor metabolic process (GO:0006505)2.41827543
123positive regulation of action potential (GO:0045760)2.41553881
124cranial nerve development (GO:0021545)2.41429958
125regulation of catecholamine metabolic process (GO:0042069)2.41425029
126regulation of dopamine metabolic process (GO:0042053)2.41425029
127negative regulation of DNA recombination (GO:0045910)2.40258428
128establishment of melanosome localization (GO:0032401)2.39983047
129intraciliary transport (GO:0042073)2.39815124
130cellular response to hepatocyte growth factor stimulus (GO:0035729)2.39468684
131response to hepatocyte growth factor (GO:0035728)2.39468684
132cell migration in hindbrain (GO:0021535)2.38500517
133mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.37843843
134positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.37843843
135lateral sprouting from an epithelium (GO:0060601)2.36643029
136neurotransmitter-gated ion channel clustering (GO:0072578)2.36066474
137nucleotide transmembrane transport (GO:1901679)2.35449714
138microtubule-based transport (GO:0010970)2.33106427
139neurotransmitter secretion (GO:0007269)2.32825734
140positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.32283226
141organelle transport along microtubule (GO:0072384)2.32075814
142mannosylation (GO:0097502)2.31692057
143synaptic vesicle endocytosis (GO:0048488)2.31113753
144proteasome assembly (GO:0043248)2.30675143
145regulation of feeding behavior (GO:0060259)2.30309046
146ear development (GO:0043583)2.28454408
147dendritic spine morphogenesis (GO:0060997)2.27756631
148axonal fasciculation (GO:0007413)2.27157209
149neurotransmitter catabolic process (GO:0042135)2.26652158
150melanosome transport (GO:0032402)2.25789199
151deoxyribonucleotide biosynthetic process (GO:0009263)2.25381229
152axon development (GO:0061564)2.25259117
153Golgi to plasma membrane protein transport (GO:0043001)2.25014360
154mitochondrion transport along microtubule (GO:0047497)2.24352936
155establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.24352936
156metallo-sulfur cluster assembly (GO:0031163)2.24336666
157iron-sulfur cluster assembly (GO:0016226)2.24336666
158peripheral nervous system development (GO:0007422)2.24033662
159establishment of vesicle localization (GO:0051650)2.23881014
160L-amino acid import (GO:0043092)2.23370322
161regulation of autophagic vacuole assembly (GO:2000785)2.22364394
162membrane budding (GO:0006900)2.21672360
163establishment of pigment granule localization (GO:0051905)2.21580637
164retinal ganglion cell axon guidance (GO:0031290)2.21396603
165positive regulation of glial cell differentiation (GO:0045687)2.21356945
166neurotransmitter uptake (GO:0001504)2.21173475
167growth hormone secretion (GO:0030252)2.19944404
168cerebellar granule cell differentiation (GO:0021707)2.19325181
169DNA integration (GO:0015074)2.18952850
170mitochondrial fission (GO:0000266)2.18658492
171ubiquinone metabolic process (GO:0006743)2.18413982
172chromatin remodeling at centromere (GO:0031055)2.17841037
173protein polyglutamylation (GO:0018095)2.16248034
174CENP-A containing nucleosome assembly (GO:0034080)2.16208294
175regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.15923364
176L-serine metabolic process (GO:0006563)2.15137337

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.11402150
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.49551287
3RBPJ_22232070_ChIP-Seq_NCS_Mouse2.62352040
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.52095869
5GBX2_23144817_ChIP-Seq_PC3_Human2.48701506
6* CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.30673270
7SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.29723090
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.29091485
9PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27329207
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.26648775
11EZH2_22144423_ChIP-Seq_EOC_Human2.17969071
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.16925081
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14007599
14E2F7_22180533_ChIP-Seq_HELA_Human2.07101635
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.05916833
16EZH2_27304074_Chip-Seq_ESCs_Mouse1.99944574
17TAF15_26573619_Chip-Seq_HEK293_Human1.97255100
18ELK1_19687146_ChIP-ChIP_HELA_Human1.93854860
19E2F4_17652178_ChIP-ChIP_JURKAT_Human1.91004406
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.90954555
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.88791235
22OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.87731261
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.82927100
24FUS_26573619_Chip-Seq_HEK293_Human1.80416971
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.79140131
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.78667063
27POU5F1_16153702_ChIP-ChIP_HESCs_Human1.78467587
28VDR_22108803_ChIP-Seq_LS180_Human1.75531130
29* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.73595311
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.73436928
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.72959881
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70333683
33GABP_19822575_ChIP-Seq_HepG2_Human1.70179613
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68152673
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.67947196
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65670994
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.65386054
38* DCP1A_22483619_ChIP-Seq_HELA_Human1.64069040
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61442192
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.59597895
41* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.58438456
42SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.57781780
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.57508766
44PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.57217277
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53254243
46SOX2_16153702_ChIP-ChIP_HESCs_Human1.50574222
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47219436
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46499249
49WT1_19549856_ChIP-ChIP_CCG9911_Human1.46321018
50VDR_23849224_ChIP-Seq_CD4+_Human1.44522427
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44139047
52FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.43692079
53SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43129528
54ER_23166858_ChIP-Seq_MCF-7_Human1.42741998
55EZH2_18974828_ChIP-Seq_MESCs_Mouse1.40926025
56RNF2_18974828_ChIP-Seq_MESCs_Mouse1.40926025
57* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40806356
58CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.40556998
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40129428
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.39865208
61MYC_18940864_ChIP-ChIP_HL60_Human1.38679036
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38021065
63* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37600769
64* XRN2_22483619_ChIP-Seq_HELA_Human1.35086106
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34703007
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33761713
67EZH2_27294783_Chip-Seq_ESCs_Mouse1.33535761
68* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.33303494
69* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33227773
70* TTF2_22483619_ChIP-Seq_HELA_Human1.32552627
71JARID2_20075857_ChIP-Seq_MESCs_Mouse1.31730178
72MYC_18358816_ChIP-ChIP_MESCs_Mouse1.31476172
73MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31216821
74SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.29862652
75ZNF274_21170338_ChIP-Seq_K562_Hela1.29241358
76CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28495146
77REST_21632747_ChIP-Seq_MESCs_Mouse1.27877051
78EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.26963747
79POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.26144456
80ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25508514
81FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.25386201
82SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24388324
83MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23349779
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22178449
85* RNF2_27304074_Chip-Seq_NSC_Mouse1.21780521
86SOX17_20123909_ChIP-Seq_XEN_Mouse1.20964526
87SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.20582679
88EWS_26573619_Chip-Seq_HEK293_Human1.19457017
89SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.19147090
90RNF2_27304074_Chip-Seq_ESCs_Mouse1.18538098
91NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18274301
92TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16701446
93* REST_18959480_ChIP-ChIP_MESCs_Mouse1.16266511
94SMAD3_21741376_ChIP-Seq_EPCs_Human1.15845944
95SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.15716534
96EOMES_21245162_ChIP-Seq_HESCs_Human1.15387361
97GATA1_26923725_Chip-Seq_HPCs_Mouse1.14785135
98SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.13393912
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11054866
100* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10899314
101FOXP3_21729870_ChIP-Seq_TREG_Human1.09146309
102REST_19997604_ChIP-ChIP_NEURONS_Mouse1.09028180
103* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07898676
104SOX9_26525672_Chip-Seq_HEART_Mouse1.05862428
105IRF1_19129219_ChIP-ChIP_H3396_Human1.05810508
106POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04950041
107KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.04563765
108KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.04563765
109KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.04563765
110* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03243817
111NANOG_16153702_ChIP-ChIP_HESCs_Human1.02519721
112RARB_27405468_Chip-Seq_BRAIN_Mouse1.01226602
113GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00864576
114SRF_21415370_ChIP-Seq_HL-1_Mouse1.00530690
115AR_21909140_ChIP-Seq_LNCAP_Human1.00401599
116SALL1_21062744_ChIP-ChIP_HESCs_Human1.00113442
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99258304
118CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98786592
119AR_21572438_ChIP-Seq_LNCaP_Human0.97548842
120OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97307889
121P300_19829295_ChIP-Seq_ESCs_Human0.97038333
122SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96800020
123POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.95326386
124TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94689456
125* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94195017
126ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92483638
127DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91978875
128* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90869898
129P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88883542
130MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.88692974
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87442764
132SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86636541
133ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.86100066
134YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85593203
135IGF1R_20145208_ChIP-Seq_DFB_Human0.85281581
136E2F1_18555785_ChIP-Seq_MESCs_Mouse0.85277571
137* MYC_18555785_ChIP-Seq_MESCs_Mouse0.85024844
138TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.84846565
139JUN_21703547_ChIP-Seq_K562_Human0.83000973
140YY1_21170310_ChIP-Seq_MESCs_Mouse0.81926164

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.77213522
2MP0000920_abnormal_myelination3.49214599
3MP0001529_abnormal_vocalization3.16663473
4MP0004270_analgesia3.14047352
5MP0005499_abnormal_olfactory_system2.71939964
6MP0005394_taste/olfaction_phenotype2.71939964
7MP0002822_catalepsy2.65281778
8MP0008789_abnormal_olfactory_epithelium2.53840063
9MP0000778_abnormal_nervous_system2.44982814
10MP0001905_abnormal_dopamine_level2.30805949
11MP0001984_abnormal_olfaction2.27067589
12MP0002272_abnormal_nervous_system2.14871413
13MP0004885_abnormal_endolymph2.13062678
14MP0004859_abnormal_synaptic_plasticity2.10976979
15MP0001485_abnormal_pinna_reflex2.09054487
16MP0004742_abnormal_vestibular_system2.03627846
17MP0002734_abnormal_mechanical_nocicepti1.91643703
18MP0001486_abnormal_startle_reflex1.88606586
19MP0003136_yellow_coat_color1.88325670
20MP0005171_absent_coat_pigmentation1.86783800
21MP0003329_amyloid_beta_deposits1.85574073
22MP0003950_abnormal_plasma_membrane1.85282535
23MP0002064_seizures1.84124290
24MP0000462_abnormal_digestive_system1.83305814
25MP0003634_abnormal_glial_cell1.82051788
26MP0000537_abnormal_urethra_morphology1.80183773
27MP0004142_abnormal_muscle_tone1.78064401
28MP0003635_abnormal_synaptic_transmissio1.75778833
29MP0003122_maternal_imprinting1.75562337
30MP0008058_abnormal_DNA_repair1.66444128
31MP0005423_abnormal_somatic_nervous1.62491275
32MP0000955_abnormal_spinal_cord1.58587785
33MP0006072_abnormal_retinal_apoptosis1.53572165
34MP0009745_abnormal_behavioral_response1.50318320
35MP0001299_abnormal_eye_distance/1.48968720
36MP0000049_abnormal_middle_ear1.48764281
37MP0003937_abnormal_limbs/digits/tail_de1.45497320
38MP0009046_muscle_twitch1.44277688
39MP0002882_abnormal_neuron_morphology1.43395530
40MP0004133_heterotaxia1.41971473
41MP0002234_abnormal_pharynx_morphology1.41941911
42MP0003690_abnormal_glial_cell1.41599274
43MP0005187_abnormal_penis_morphology1.40697046
44MP0002063_abnormal_learning/memory/cond1.39462394
45MP0004134_abnormal_chest_morphology1.37883747
46MP0003632_abnormal_nervous_system1.36978217
47MP0010094_abnormal_chromosome_stability1.36295280
48MP0002572_abnormal_emotion/affect_behav1.35443514
49MP0002229_neurodegeneration1.35251872
50MP0006276_abnormal_autonomic_nervous1.34016225
51MP0001440_abnormal_grooming_behavior1.33481423
52MP0003121_genomic_imprinting1.32700862
53MP0003938_abnormal_ear_development1.29417645
54MP0002938_white_spotting1.29389338
55MP0008932_abnormal_embryonic_tissue1.29217950
56MP0005409_darkened_coat_color1.27712699
57MP0002184_abnormal_innervation1.26914424
58MP0002752_abnormal_somatic_nervous1.25420418
59MP0008877_abnormal_DNA_methylation1.24189743
60MP0003123_paternal_imprinting1.23119883
61MP0003890_abnormal_embryonic-extraembry1.22482998
62MP0002233_abnormal_nose_morphology1.21136402
63MP0003119_abnormal_digestive_system1.20545956
64MP0008260_abnormal_autophagy1.19666148
65MP0003693_abnormal_embryo_hatching1.19305856
66MP0004924_abnormal_behavior1.19004244
67MP0005386_behavior/neurological_phenoty1.19004244
68MP0001963_abnormal_hearing_physiology1.18917909
69MP0005410_abnormal_fertilization1.18780260
70MP0004043_abnormal_pH_regulation1.18702576
71MP0000566_synostosis1.18207191
72MP0002066_abnormal_motor_capabilities/c1.17926819
73MP0001970_abnormal_pain_threshold1.16684727
74MP0000631_abnormal_neuroendocrine_gland1.16193468
75MP0002152_abnormal_brain_morphology1.15567947
76MP0002733_abnormal_thermal_nociception1.14934187
77MP0009697_abnormal_copulation1.14546004
78MP0002067_abnormal_sensory_capabilities1.14126777
79MP0003861_abnormal_nervous_system1.12972923
80MP0006035_abnormal_mitochondrial_morpho1.11756069
81MP0003385_abnormal_body_wall1.10056961
82MP0005623_abnormal_meninges_morphology1.09424028
83MP0003283_abnormal_digestive_organ1.09404258
84MP0010030_abnormal_orbit_morphology1.06716908
85MP0005248_abnormal_Harderian_gland1.06580931
86MP0000751_myopathy1.04815639
87MP0002638_abnormal_pupillary_reflex1.04595284
88MP0002751_abnormal_autonomic_nervous1.04202264
89MP0005551_abnormal_eye_electrophysiolog1.03974288
90MP0001293_anophthalmia1.03269282
91MP0006292_abnormal_olfactory_placode1.03175959
92MP0003567_abnormal_fetal_cardiomyocyte1.02272991
93MP0002735_abnormal_chemical_nociception1.01081066
94MP0010678_abnormal_skin_adnexa1.01019619
95MP0001968_abnormal_touch/_nociception1.00081318
96MP0003111_abnormal_nucleus_morphology0.99623681
97MP0001346_abnormal_lacrimal_gland0.99596756
98MP0000026_abnormal_inner_ear0.99388826
99MP0002102_abnormal_ear_morphology0.98611218
100MP0009250_abnormal_appendicular_skeleto0.95579527
101MP0004957_abnormal_blastocyst_morpholog0.94430447
102MP0001727_abnormal_embryo_implantation0.93267449
103MP0005253_abnormal_eye_physiology0.92639631
104MP0000383_abnormal_hair_follicle0.91314643
105MP0000762_abnormal_tongue_morphology0.90550899
106MP0005084_abnormal_gallbladder_morpholo0.90325717
107MP0002557_abnormal_social/conspecific_i0.90186081
108MP0004811_abnormal_neuron_physiology0.89416591
109MP0002090_abnormal_vision0.88927168
110MP0003077_abnormal_cell_cycle0.88775343
111MP0004197_abnormal_fetal_growth/weight/0.88232203
112MP0002697_abnormal_eye_size0.87867502
113MP0002909_abnormal_adrenal_gland0.87770483
114MP0008007_abnormal_cellular_replicative0.87503365
115MP0005645_abnormal_hypothalamus_physiol0.86348581
116MP0002653_abnormal_ependyma_morphology0.86315252
117MP0001286_abnormal_eye_development0.85082021
118MP0005391_vision/eye_phenotype0.85037058
119MP0003755_abnormal_palate_morphology0.84902015
120MP0005195_abnormal_posterior_eye0.84367886
121MP0002736_abnormal_nociception_after0.83657403
122MP0003315_abnormal_perineum_morphology0.83575954
123* MP0003221_abnormal_cardiomyocyte_apopto0.81301218
124MP0001502_abnormal_circadian_rhythm0.81012789
125MP0002081_perinatal_lethality0.80603387
126MP0002069_abnormal_eating/drinking_beha0.80484965
127MP0002177_abnormal_outer_ear0.80219476
128MP0003787_abnormal_imprinting0.80174052
129MP0003631_nervous_system_phenotype0.78992561
130MP0008569_lethality_at_weaning0.78892825
131MP0001188_hyperpigmentation0.77861633
132MP0000534_abnormal_ureter_morphology0.76927502
133MP0000647_abnormal_sebaceous_gland0.76243902
134MP0000747_muscle_weakness0.74522617
135MP0003718_maternal_effect0.74064289
136MP0001177_atelectasis0.73142355
137MP0005379_endocrine/exocrine_gland_phen0.72848613
138MP0008057_abnormal_DNA_replication0.72835729
139MP0003698_abnormal_male_reproductive0.71852548

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)5.05101746
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.05101746
3Cerebral hypomyelination (HP:0006808)4.96381774
4Cortical dysplasia (HP:0002539)4.37854183
5Neurofibrillary tangles (HP:0002185)4.11689224
6Sensory axonal neuropathy (HP:0003390)3.96317197
7Abnormality of the corticospinal tract (HP:0002492)3.81246282
8Abnormality of glycolysis (HP:0004366)3.61743609
9Increased serum pyruvate (HP:0003542)3.61743609
10Parakeratosis (HP:0001036)3.46443160
11Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.40676720
12Peripheral hypomyelination (HP:0007182)3.34751312
13Cerebral inclusion bodies (HP:0100314)3.07245550
14Amyotrophic lateral sclerosis (HP:0007354)3.07147000
15Shoulder girdle muscle weakness (HP:0003547)3.06626720
16CNS hypomyelination (HP:0003429)3.02875274
17Nephrogenic diabetes insipidus (HP:0009806)3.02523805
18Atrophy/Degeneration involving motor neurons (HP:0007373)2.93864186
19Urinary urgency (HP:0000012)2.92985087
20Alacrima (HP:0000522)2.92517210
21Hypoplastic pelvis (HP:0008839)2.92443895
22Spastic gait (HP:0002064)2.89967279
23Leukodystrophy (HP:0002415)2.79881639
24Abnormality of the musculature of the pelvis (HP:0001469)2.77571624
25Abnormality of the hip-girdle musculature (HP:0001445)2.77571624
26Drooling (HP:0002307)2.69234015
27Retinal dysplasia (HP:0007973)2.66771040
28Aplasia/Hypoplasia of the brainstem (HP:0007362)2.66586601
29Hypoplasia of the brainstem (HP:0002365)2.66586601
30Polyphagia (HP:0002591)2.61189756
31Myokymia (HP:0002411)2.58956953
32Termporal pattern (HP:0011008)2.54552256
33Insidious onset (HP:0003587)2.54552256
34Split foot (HP:0001839)2.53788826
35Failure to thrive in infancy (HP:0001531)2.53608880
36Supranuclear gaze palsy (HP:0000605)2.53211307
37Pheochromocytoma (HP:0002666)2.52559102
38Postnatal microcephaly (HP:0005484)2.51965143
39Irregular epiphyses (HP:0010582)2.50185952
40Abnormal auditory evoked potentials (HP:0006958)2.46088892
41Ankle clonus (HP:0011448)2.43064471
42Acute necrotizing encephalopathy (HP:0006965)2.41673864
43Specific learning disability (HP:0001328)2.41606343
44Anteriorly placed anus (HP:0001545)2.40187201
45Abnormality of the lower motor neuron (HP:0002366)2.40137016
46Akinesia (HP:0002304)2.38516477
47Excessive salivation (HP:0003781)2.35934651
48Autoamputation (HP:0001218)2.31259268
49Decreased lacrimation (HP:0000633)2.30462810
50Pelvic girdle muscle weakness (HP:0003749)2.29181579
51Hyperglycinemia (HP:0002154)2.28731478
52Neuroendocrine neoplasm (HP:0100634)2.28080418
53Adrenal hypoplasia (HP:0000835)2.26056573
54Small epiphyses (HP:0010585)2.25461166
55Congenital ichthyosiform erythroderma (HP:0007431)2.23963310
56Absent septum pellucidum (HP:0001331)2.23096790
57Degeneration of anterior horn cells (HP:0002398)2.22309245
58Abnormality of the anterior horn cell (HP:0006802)2.22309245
59Medulloblastoma (HP:0002885)2.21954931
60Vaginal atresia (HP:0000148)2.21797681
61Morphological abnormality of the inner ear (HP:0011390)2.20032831
62Broad foot (HP:0001769)2.19330816
63Pachygyria (HP:0001302)2.17972899
64Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.17798785
65Onion bulb formation (HP:0003383)2.17393249
66Abnormality of the labia minora (HP:0012880)2.16927028
67Hypsarrhythmia (HP:0002521)2.12269808
68Thickened helices (HP:0000391)2.12233687
69Stenosis of the external auditory canal (HP:0000402)2.12107547
70Genital tract atresia (HP:0001827)2.12086328
71Impaired vibration sensation in the lower limbs (HP:0002166)2.11463771
72Poor suck (HP:0002033)2.11151499
73Dysmetria (HP:0001310)2.11026544
74Spastic paraparesis (HP:0002313)2.07337904
75Abnormality of the phalanges of the 2nd finger (HP:0009541)2.06590757
76Intention tremor (HP:0002080)2.06585979
77Abnormality of the septum pellucidum (HP:0007375)2.04304283
78EEG with generalized epileptiform discharges (HP:0011198)2.04037439
79Colon cancer (HP:0003003)2.02630289
80Atonic seizures (HP:0010819)2.00527301
81Scanning speech (HP:0002168)2.00290508
82Focal motor seizures (HP:0011153)2.00100319
83Esophageal atresia (HP:0002032)1.99930850
84Abnormal mitochondria in muscle tissue (HP:0008316)1.97819863
85Epileptiform EEG discharges (HP:0011182)1.97734604
86Limb dystonia (HP:0002451)1.97699740
87Limb-girdle muscle atrophy (HP:0003797)1.96352096
88Spastic tetraplegia (HP:0002510)1.96349592
89Megalencephaly (HP:0001355)1.94867330
90Abnormality of the metopic suture (HP:0005556)1.94283457
91Decreased testicular size (HP:0008734)1.93934531
92Poor coordination (HP:0002370)1.92722211
93Mitochondrial inheritance (HP:0001427)1.91231681
94Poor speech (HP:0002465)1.89744900
95Muscular hypotonia of the trunk (HP:0008936)1.88004232
96Hepatoblastoma (HP:0002884)1.87193764
97Abnormality of the motor neurons (HP:0002450)1.86231286
98Abnormal neuron morphology (HP:0012757)1.86231286
99Cupped ear (HP:0000378)1.85687028
100Polymicrogyria (HP:0002126)1.85414132
101Spastic diplegia (HP:0001264)1.85206477
102Progressive macrocephaly (HP:0004481)1.84795309
103Rimmed vacuoles (HP:0003805)1.83082192
104Progressive inability to walk (HP:0002505)1.81368374
105Delayed epiphyseal ossification (HP:0002663)1.79552154
106Gait imbalance (HP:0002141)1.79058983
107Postaxial hand polydactyly (HP:0001162)1.79006252
108Epiphyseal dysplasia (HP:0002656)1.78860536
109Absent epiphyses (HP:0010577)1.78675084
110Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.78675084
111Abnormality of the fetal cardiovascular system (HP:0010948)1.78116040
112Abnormal umbilical cord blood vessels (HP:0011403)1.78116040
113Single umbilical artery (HP:0001195)1.78116040
114Upper limb muscle weakness (HP:0003484)1.77953870
115Limb-girdle muscle weakness (HP:0003325)1.75946933
116Type II lissencephaly (HP:0007260)1.74781053
117Stridor (HP:0010307)1.73834435
118Acute encephalopathy (HP:0006846)1.73297862
119Septo-optic dysplasia (HP:0100842)1.73193175
120Short tibia (HP:0005736)1.71748445
121Coronal craniosynostosis (HP:0004440)1.70467772
122Myelomeningocele (HP:0002475)1.70074801
123Neonatal respiratory distress (HP:0002643)1.69880881
124Humeroradial synostosis (HP:0003041)1.69758067
125Synostosis involving the elbow (HP:0003938)1.69758067
126Delusions (HP:0000746)1.68754418
127Medial flaring of the eyebrow (HP:0010747)1.67969136
128Micropenis (HP:0000054)1.67304294
129Increased circulating renin level (HP:0000848)1.66132737
130Prominent metopic ridge (HP:0005487)1.66063738
131Broad distal phalanx of finger (HP:0009836)1.65881464
132Morphological abnormality of the pyramidal tract (HP:0002062)1.62734510
133Esotropia (HP:0000565)1.62573932
134Renal Fanconi syndrome (HP:0001994)1.61383830
135Lissencephaly (HP:0001339)1.60159133
136Focal seizures (HP:0007359)1.60009496
137Hand muscle atrophy (HP:0009130)1.60008477
138Bowel incontinence (HP:0002607)1.58433012
139Clonus (HP:0002169)1.58341642
140Segmental peripheral demyelination/remyelination (HP:0003481)1.57185925
141Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.56774910
142Decreased activity of mitochondrial respiratory chain (HP:0008972)1.56774910
143Increased hepatocellular lipid droplets (HP:0006565)1.55682986
144Hypoplasia of the capital femoral epiphysis (HP:0003090)1.55525197
145Mixed hearing impairment (HP:0000410)1.55139677
146Inability to walk (HP:0002540)1.54609621
147Heterochromia iridis (HP:0001100)1.54116704
148Hypoplasia of the corpus callosum (HP:0002079)1.54040455
149Aplasia/Hypoplasia of the lens (HP:0008063)1.53690446
150Thyroid-stimulating hormone excess (HP:0002925)1.53590541
151Epileptic encephalopathy (HP:0200134)1.53547680
152Abnormality of the umbilical cord (HP:0010881)1.53419042
153Congenital primary aphakia (HP:0007707)1.52840560
154Tubulointerstitial nephritis (HP:0001970)1.52138187
155Lower limb muscle weakness (HP:0007340)1.51842367
156True hermaphroditism (HP:0010459)1.50868069
157Relative macrocephaly (HP:0004482)1.50834779
158Fibular aplasia (HP:0002990)1.49927950
159Hypomagnesemia (HP:0002917)1.49690259
160Abnormality of the middle phalanges of the toes (HP:0010183)1.49627476
1613-Methylglutaconic aciduria (HP:0003535)1.49325550
162Occipital encephalocele (HP:0002085)1.49192211
163Abnormality of the astrocytes (HP:0100707)1.48956551
164Breast hypoplasia (HP:0003187)1.48622687
165Partial agenesis of the corpus callosum (HP:0001338)1.48302218
166Hepatocellular necrosis (HP:0001404)1.47008314
167Cerebral hemorrhage (HP:0001342)1.46554930

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.22398524
2OXSR13.89223871
3TRIM283.68102433
4MAP2K73.34151984
5LIMK12.99836488
6PNCK2.85105524
7CDK192.64916167
8MAP4K22.53121392
9ERBB32.35722996
10UHMK12.35327943
11BUB12.35081794
12PBK2.30031323
13TESK22.28643159
14WNK42.23365034
15MARK12.21199747
16MET1.99558661
17DYRK21.95026069
18NEK11.87837669
19PRPF4B1.83921881
20PKN11.81037193
21TNIK1.80514118
22BCKDK1.76072480
23FGFR21.70008068
24STK161.67938845
25RPS6KA41.61359428
26NEK61.56853405
27MAPKAPK51.53915511
28CAMK2B1.53188840
29NTRK11.50061337
30EPHB11.49749173
31EPHA31.44539150
32SIK31.41605941
33ROCK21.40434113
34* BCR1.38259862
35WNK11.33063529
36CASK1.31168067
37ARAF1.26033174
38MST41.25206561
39PAK61.22355342
40CDK181.20440705
41MKNK11.20166571
42CDK151.19458742
43ICK1.13571389
44CAMK2D1.12306883
45CDK11A1.09627659
46SCYL21.08448570
47BMPR1B1.06960467
48* CDK141.06853341
49MAPK131.05526966
50MAP2K41.05470513
51PAK31.03692217
52EPHA41.03293614
53NME11.01068988
54CLK10.98436149
55FGR0.97162616
56EIF2AK10.95921478
57* CSNK1G10.95708635
58TYRO30.94871741
59PIM20.94229649
60WNK30.94084487
61VRK10.92182249
62PLK10.91212570
63WEE10.90248150
64PINK10.90188607
65TSSK60.89014971
66DYRK1B0.88994313
67PLK20.88006308
68PASK0.87698193
69CDK50.87635357
70MINK10.86176085
71EIF2AK30.83132749
72KSR10.82075969
73CAMK2G0.80055362
74PLK30.79257211
75CCNB10.76688288
76TESK10.73705265
77CAMK2A0.73463471
78SGK4940.72414307
79SGK2230.72414307
80EPHB20.71032700
81SRPK10.70391492
82PAK10.70121208
83MAPK150.68919132
84STK38L0.68635881
85BRAF0.67119537
86MAP3K60.66684081
87AURKA0.66002895
88* CSNK1G30.62945408
89NTRK30.62825678
90DAPK10.62717252
91DYRK1A0.61347044
92MAP3K90.59292750
93VRK20.59182855
94ATR0.58739902
95ZAK0.57930975
96TLK10.57566517
97NTRK20.57217056
98KSR20.56420163
99PRKCE0.55370610
100DYRK30.53328683
101MAP3K50.52979155
102RPS6KA50.52456512
103CDC70.52055877
104AURKB0.51255276
105EPHA20.50730332
106PAK40.50317262
107IRAK20.49881118
108MAP3K120.49487769
109ERBB40.49332820
110LMTK20.47820853
111FLT30.46387991
112CAMKK20.45396041
113EIF2AK20.42524362
114PRKCG0.42392493
115PRKD30.39792740
116CHEK20.39221869
117PHKG10.38948363
118PHKG20.38948363
119ATM0.38587206
120MAPK90.37431688
121* CSNK1E0.37109921
122MAP3K20.36541176
123BRSK20.36375209
124MELK0.35561422
125DDR20.35501530
126MKNK20.35064876
127PRKACB0.33685255
128BRSK10.33593452
129CDK10.32838613
130FYN0.32771778
131TTK0.31827581
132* CSNK1A1L0.31446522
133CSNK2A10.31423035
134MARK20.31335122
135MAP3K40.31206532
136CDK80.30982640
137PLK40.30933018
138FER0.30726193
139* CSNK1G20.30104372
140ROCK10.30079395
141PRKG10.29569546

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.06682467
2Steroid biosynthesis_Homo sapiens_hsa001003.34207115
3Protein export_Homo sapiens_hsa030603.10086084
4Oxidative phosphorylation_Homo sapiens_hsa001902.92798184
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.72126078
6Fatty acid elongation_Homo sapiens_hsa000622.68758332
7Proteasome_Homo sapiens_hsa030502.64586299
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.58108329
9Parkinsons disease_Homo sapiens_hsa050122.40877162
10Ether lipid metabolism_Homo sapiens_hsa005652.11493387
11RNA polymerase_Homo sapiens_hsa030202.11450277
12Alzheimers disease_Homo sapiens_hsa050101.88382058
13Axon guidance_Homo sapiens_hsa043601.87789944
14Vibrio cholerae infection_Homo sapiens_hsa051101.81140691
15Huntingtons disease_Homo sapiens_hsa050161.74088302
16Base excision repair_Homo sapiens_hsa034101.73398139
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.63890484
18Vitamin B6 metabolism_Homo sapiens_hsa007501.50748119
19Basal transcription factors_Homo sapiens_hsa030221.49250558
20Biosynthesis of amino acids_Homo sapiens_hsa012301.45382327
21Collecting duct acid secretion_Homo sapiens_hsa049661.42506912
22Sphingolipid metabolism_Homo sapiens_hsa006001.40804440
23Spliceosome_Homo sapiens_hsa030401.36997319
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35865310
25Serotonergic synapse_Homo sapiens_hsa047261.34192054
26Sulfur metabolism_Homo sapiens_hsa009201.29447522
27GABAergic synapse_Homo sapiens_hsa047271.28257385
28Fanconi anemia pathway_Homo sapiens_hsa034601.28250515
29Synaptic vesicle cycle_Homo sapiens_hsa047211.23948357
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17763199
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16300886
32Nicotine addiction_Homo sapiens_hsa050331.15861002
33Tight junction_Homo sapiens_hsa045301.13743260
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13491563
35Long-term depression_Homo sapiens_hsa047301.12360985
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11750645
37Propanoate metabolism_Homo sapiens_hsa006401.11257190
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.11031206
39Hedgehog signaling pathway_Homo sapiens_hsa043401.10873508
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.10090783
41Carbon metabolism_Homo sapiens_hsa012001.09328950
42Glutamatergic synapse_Homo sapiens_hsa047241.08748244
43Renal cell carcinoma_Homo sapiens_hsa052111.08553790
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.08487482
45Cardiac muscle contraction_Homo sapiens_hsa042601.06551238
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04870129
47Alcoholism_Homo sapiens_hsa050341.02961320
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02862982
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.00300554
50Dopaminergic synapse_Homo sapiens_hsa047280.99997968
51Mismatch repair_Homo sapiens_hsa034300.97187094
52Nucleotide excision repair_Homo sapiens_hsa034200.96985171
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95975118
54Pyruvate metabolism_Homo sapiens_hsa006200.94643112
55Cocaine addiction_Homo sapiens_hsa050300.94312884
56Linoleic acid metabolism_Homo sapiens_hsa005910.93687825
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.92702518
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91868541
59Morphine addiction_Homo sapiens_hsa050320.91487784
60RNA transport_Homo sapiens_hsa030130.90388228
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87739774
62* Oocyte meiosis_Homo sapiens_hsa041140.86895864
63Circadian entrainment_Homo sapiens_hsa047130.82632692
64Phototransduction_Homo sapiens_hsa047440.81940624
65Amphetamine addiction_Homo sapiens_hsa050310.77840215
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77443044
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75887034
68Gap junction_Homo sapiens_hsa045400.75749554
69Non-homologous end-joining_Homo sapiens_hsa034500.73909493
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73120437
71Ribosome_Homo sapiens_hsa030100.72936658
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72817751
73Regulation of autophagy_Homo sapiens_hsa041400.72053307
74Endocytosis_Homo sapiens_hsa041440.70925718
75Fatty acid metabolism_Homo sapiens_hsa012120.69549892
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69176527
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67446482
78* Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66527302
79DNA replication_Homo sapiens_hsa030300.66243101
80Homologous recombination_Homo sapiens_hsa034400.65616699
81Long-term potentiation_Homo sapiens_hsa047200.65543809
82mRNA surveillance pathway_Homo sapiens_hsa030150.65104311
83Purine metabolism_Homo sapiens_hsa002300.65095874
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64301307
85Pyrimidine metabolism_Homo sapiens_hsa002400.62273644
86Cholinergic synapse_Homo sapiens_hsa047250.62259186
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.62199832
88Wnt signaling pathway_Homo sapiens_hsa043100.60838920
89Shigellosis_Homo sapiens_hsa051310.60399338
90Butanoate metabolism_Homo sapiens_hsa006500.60054685
91Peroxisome_Homo sapiens_hsa041460.59832015
92Folate biosynthesis_Homo sapiens_hsa007900.59141227
93Glutathione metabolism_Homo sapiens_hsa004800.58828349
94Taste transduction_Homo sapiens_hsa047420.58303497
95* Cell cycle_Homo sapiens_hsa041100.58197566
96* Hippo signaling pathway_Homo sapiens_hsa043900.57707499
97beta-Alanine metabolism_Homo sapiens_hsa004100.56342631
98Ras signaling pathway_Homo sapiens_hsa040140.56308916
99Basal cell carcinoma_Homo sapiens_hsa052170.56139704
100Arginine and proline metabolism_Homo sapiens_hsa003300.55578133
101Circadian rhythm_Homo sapiens_hsa047100.55433569
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55267150
103Selenocompound metabolism_Homo sapiens_hsa004500.53808638
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.52857678
105Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.51509123
106ErbB signaling pathway_Homo sapiens_hsa040120.51438460
107Phagosome_Homo sapiens_hsa041450.49148390
108Arachidonic acid metabolism_Homo sapiens_hsa005900.47609297
109Sulfur relay system_Homo sapiens_hsa041220.46928204
110Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46078815
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45075163
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.44570631
113Melanogenesis_Homo sapiens_hsa049160.44313724
114p53 signaling pathway_Homo sapiens_hsa041150.44229425
115Insulin secretion_Homo sapiens_hsa049110.43632946
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43118742
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42861995
118N-Glycan biosynthesis_Homo sapiens_hsa005100.41919624
119Rheumatoid arthritis_Homo sapiens_hsa053230.41062686
120Metabolic pathways_Homo sapiens_hsa011000.40287790
121Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40106927
122RNA degradation_Homo sapiens_hsa030180.38384075
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37754546
124Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35964128
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.35486255
126Gastric acid secretion_Homo sapiens_hsa049710.35070889
127Salivary secretion_Homo sapiens_hsa049700.33886931
128Pancreatic secretion_Homo sapiens_hsa049720.32626283
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.31304178
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.31146607
131TGF-beta signaling pathway_Homo sapiens_hsa043500.30355639

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