ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.33909086
2	response to pheromone (GO:0019236)	4.51831814
3	L-fucose metabolic process (GO:0042354)	4.49581801
4	L-fucose catabolic process (GO:0042355)	4.49581801
5	fucose catabolic process (GO:0019317)	4.49581801
6	DNA deamination (GO:0045006)	4.26258468
7	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.04482413
8	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.67798009
9	tryptophan catabolic process (GO:0006569)	3.66469792
10	indole-containing compound catabolic process (GO:0042436)	3.66469792
11	indolalkylamine catabolic process (GO:0046218)	3.66469792
12	indolalkylamine metabolic process (GO:0006586)	3.60985319
13	detection of light stimulus involved in visual perception (GO:0050908)	3.57263248
14	detection of light stimulus involved in sensory perception (GO:0050962)	3.57263248
15	water-soluble vitamin biosynthetic process (GO:0042364)	3.54909337
16	kynurenine metabolic process (GO:0070189)	3.54454223
17	protein polyglutamylation (GO:0018095)	3.48075307
18	regulation of cilium movement (GO:0003352)	3.45764820
19	platelet dense granule organization (GO:0060155)	3.34506554
20	NADH dehydrogenase complex assembly (GO:0010257)	3.33033462
21	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.33033462
22	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.33033462
23	protein complex biogenesis (GO:0070271)	3.32002567
24	epithelial cilium movement (GO:0003351)	3.31087541
25	axoneme assembly (GO:0035082)	3.30528305
26	protein-cofactor linkage (GO:0018065)	3.24471065
27	negative regulation of telomere maintenance (GO:0032205)	3.23005983
28	cellular ketone body metabolic process (GO:0046950)	3.22965902
29	protein K11-linked deubiquitination (GO:0035871)	3.18177772
30	tryptophan metabolic process (GO:0006568)	3.17342259
31	respiratory chain complex IV assembly (GO:0008535)	3.15705428
32	nonmotile primary cilium assembly (GO:0035058)	3.09145876
33	mitochondrial respiratory chain complex assembly (GO:0033108)	3.08931720
34	sulfation (GO:0051923)	3.07803336
35	cornea development in camera-type eye (GO:0061303)	3.06043994
36	piRNA metabolic process (GO:0034587)	3.03985441
37	gamma-aminobutyric acid transport (GO:0015812)	3.02050684
38	ketone body metabolic process (GO:1902224)	2.99780387
39	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.97586968
40	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.97586968
41	adaptation of signaling pathway (GO:0023058)	2.96642538
42	neural tube formation (GO:0001841)	2.92069348
43	cytochrome complex assembly (GO:0017004)	2.85594374
44	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.85546492
45	negative regulation of mast cell activation (GO:0033004)	2.84695508
46	cilium morphogenesis (GO:0060271)	2.80568536
47	kidney morphogenesis (GO:0060993)	2.78946231
48	rhodopsin mediated signaling pathway (GO:0016056)	2.78548348
49	photoreceptor cell maintenance (GO:0045494)	2.78438855
50	indole-containing compound metabolic process (GO:0042430)	2.78105752
51	neuronal action potential (GO:0019228)	2.76231060
52	protein localization to cilium (GO:0061512)	2.75246391
53	preassembly of GPI anchor in ER membrane (GO:0016254)	2.72068361
54	behavioral response to ethanol (GO:0048149)	2.71454658
55	mannosylation (GO:0097502)	2.71282915
56	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.70985015
57	regulation of hexokinase activity (GO:1903299)	2.70873468
58	regulation of glucokinase activity (GO:0033131)	2.70873468
59	retinal cone cell development (GO:0046549)	2.67046077
60	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.66790070
61	amine catabolic process (GO:0009310)	2.66387058
62	cellular biogenic amine catabolic process (GO:0042402)	2.66387058
63	cilium organization (GO:0044782)	2.65744563
64	regulation of action potential (GO:0098900)	2.65076223
65	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.64543201
66	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.63944891
67	pyrimidine nucleobase catabolic process (GO:0006208)	2.63824746
68	synaptic transmission, cholinergic (GO:0007271)	2.63234260
69	cilium movement (GO:0003341)	2.62570278
70	glycerophospholipid catabolic process (GO:0046475)	2.62473561
71	primary amino compound metabolic process (GO:1901160)	2.61109039
72	dopamine transport (GO:0015872)	2.60704555
73	ubiquinone biosynthetic process (GO:0006744)	2.60271350
74	DNA methylation involved in gamete generation (GO:0043046)	2.59016744
75	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.58932275
76	photoreceptor cell development (GO:0042461)	2.57686754
77	cilium assembly (GO:0042384)	2.55988046
78	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.53314676
79	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.52800998
80	reflex (GO:0060004)	2.52077195
81	multicellular organism reproduction (GO:0032504)	2.51461899
82	positive regulation of fatty acid transport (GO:2000193)	2.50004391
83	regulation of telomere maintenance (GO:0032204)	2.49748638
84	ubiquinone metabolic process (GO:0006743)	2.47937575
85	replication fork processing (GO:0031297)	2.45546199
86	amino acid salvage (GO:0043102)	2.44832252
87	L-methionine salvage (GO:0071267)	2.44832252
88	L-methionine biosynthetic process (GO:0071265)	2.44832252
89	regulation of microtubule-based movement (GO:0060632)	2.44137744
90	GPI anchor metabolic process (GO:0006505)	2.43568205
91	cytidine metabolic process (GO:0046087)	2.42925556
92	cytidine catabolic process (GO:0006216)	2.42925556
93	cytidine deamination (GO:0009972)	2.42925556
94	auditory receptor cell stereocilium organization (GO:0060088)	2.42393997
95	nucleobase catabolic process (GO:0046113)	2.41554778
96	reciprocal meiotic recombination (GO:0007131)	2.39961292
97	reciprocal DNA recombination (GO:0035825)	2.39961292
98	recombinational repair (GO:0000725)	2.37998553
99	transmission of nerve impulse (GO:0019226)	2.37689867
100	neuronal action potential propagation (GO:0019227)	2.37474736

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.95331783
2	VDR_22108803_ChIP-Seq_LS180_Human	3.31718806
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.00905777
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.89483599
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.73015039
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.56011807
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.40470188
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.31218653
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.28636045
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.26658926
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.13807528
12	EWS_26573619_Chip-Seq_HEK293_Human	2.06889032
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.03748841
14	FUS_26573619_Chip-Seq_HEK293_Human	2.02437244
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.99963952
16	P300_19829295_ChIP-Seq_ESCs_Human	1.97565575
17	TAF15_26573619_Chip-Seq_HEK293_Human	1.89785508
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.87794157
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.82262494
20	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.76380492
21	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.75164125
22	IRF1_19129219_ChIP-ChIP_H3396_Human	1.72134281
23	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.71931563
24	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.71470244
25	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.65183485
26	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.64951279
27	BCAT_22108803_ChIP-Seq_LS180_Human	1.62414107
28	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.61590380
29	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.61242656
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.58003538
31	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.57935512
32	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.56639190
33	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.54387088
34	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.53222599
35	CBP_20019798_ChIP-Seq_JUKART_Human	1.51886239
36	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.51886239
37	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.50675620
38	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.49853438
39	STAT3_23295773_ChIP-Seq_U87_Human	1.48708587
40	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.45361127
41	SMAD4_21799915_ChIP-Seq_A2780_Human	1.44054950
42	AR_25329375_ChIP-Seq_VCAP_Human	1.42641256
43	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.42286206
44	TCF4_23295773_ChIP-Seq_U87_Human	1.41594778
45	REST_21632747_ChIP-Seq_MESCs_Mouse	1.37445198
46	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.37080992
47	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.36883676
48	MYC_18940864_ChIP-ChIP_HL60_Human	1.36661271
49	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.36595890
50	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.36190205
51	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.35184845
52	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.35184845
53	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.35032821
54	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.34343850
55	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.33840434
56	SOX2_19829295_ChIP-Seq_ESCs_Human	1.33712635
57	NANOG_19829295_ChIP-Seq_ESCs_Human	1.33712635
58	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.33509136
59	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.33509136
60	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.31850508
61	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.30614972
62	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.29474335
63	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.27320833
64	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.26682325
65	TCF4_22108803_ChIP-Seq_LS180_Human	1.25278142
66	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.24888645
67	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.24250948
68	RUNX2_22187159_ChIP-Seq_PCA_Human	1.23179455
69	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.22907688
70	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.22743803
71	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.21852903
72	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.21510310
73	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.18702476
74	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.17392842
75	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.17113003
76	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.16750344
77	NCOR_22424771_ChIP-Seq_293T_Human	1.15846901
78	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.15737747
79	AR_20517297_ChIP-Seq_VCAP_Human	1.15177393
80	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.13953022
81	RNF2_27304074_Chip-Seq_NSC_Mouse	1.13845925
82	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.09107599
83	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.09041307
84	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.08325181
85	HOXB7_26014856_ChIP-Seq_BT474_Human	1.08009738
86	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.07922176
87	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.07738476
88	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.06866701
89	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05946407
90	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.05082445
91	CDX2_22108803_ChIP-Seq_LS180_Human	1.01587394
92	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.00822772
93	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99689962
94	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.98051122
95	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96685496
96	ELK1_19687146_ChIP-ChIP_HELA_Human	0.95587008
97	AR_21572438_ChIP-Seq_LNCaP_Human	0.95479569
98	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.95141709
99	VDR_23849224_ChIP-Seq_CD4+_Human	0.94993635
100	MYC_19829295_ChIP-Seq_ESCs_Human	0.94946984

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	2.92610083
2	MP0008877_abnormal_DNA_methylation	2.74063688
3	MP0002102_abnormal_ear_morphology	2.63678419
4	MP0005551_abnormal_eye_electrophysiolog	2.61682347
5	MP0002837_dystrophic_cardiac_calcinosis	2.53357149
6	MP0000569_abnormal_digit_pigmentation	2.49225983
7	MP0001968_abnormal_touch/_nociception	2.45886905
8	MP0006292_abnormal_olfactory_placode	2.36096695
9	MP0003646_muscle_fatigue	2.32654616
10	MP0002876_abnormal_thyroid_physiology	2.30234723
11	MP0005645_abnormal_hypothalamus_physiol	2.22670706
12	MP0002736_abnormal_nociception_after	2.20095698
13	MP0009046_muscle_twitch	2.10454794
14	MP0003787_abnormal_imprinting	2.04045695
15	MP0006072_abnormal_retinal_apoptosis	1.99313382
16	MP0005646_abnormal_pituitary_gland	1.98334700
17	MP0008872_abnormal_physiological_respon	1.95311145
18	MP0009745_abnormal_behavioral_response	1.91855000
19	MP0005253_abnormal_eye_physiology	1.91301675
20	MP0003880_abnormal_central_pattern	1.87833794
21	MP0004142_abnormal_muscle_tone	1.85049095
22	MP0002653_abnormal_ependyma_morphology	1.84258115
23	MP0000372_irregular_coat_pigmentation	1.82660605
24	MP0004147_increased_porphyrin_level	1.79903222
25	MP0004885_abnormal_endolymph	1.78695244
26	MP0008875_abnormal_xenobiotic_pharmacok	1.78025394
27	MP0004043_abnormal_pH_regulation	1.74414426
28	MP0001986_abnormal_taste_sensitivity	1.69204632
29	MP0002272_abnormal_nervous_system	1.66095003
30	MP0002938_white_spotting	1.64155957
31	MP0003011_delayed_dark_adaptation	1.63906217
32	MP0003136_yellow_coat_color	1.61165219
33	MP0001501_abnormal_sleep_pattern	1.60710333
34	MP0006276_abnormal_autonomic_nervous	1.57723949
35	MP0002138_abnormal_hepatobiliary_system	1.56056772
36	MP0000631_abnormal_neuroendocrine_gland	1.53844858
37	MP0004133_heterotaxia	1.52238500
38	MP0001486_abnormal_startle_reflex	1.49866983
39	MP0005084_abnormal_gallbladder_morpholo	1.49679452
40	MP0000427_abnormal_hair_cycle	1.48278621
41	MP0005174_abnormal_tail_pigmentation	1.47740896
42	MP0002638_abnormal_pupillary_reflex	1.43231571
43	MP0001984_abnormal_olfaction	1.40866953
44	MP0005075_abnormal_melanosome_morpholog	1.38827042
45	MP0002733_abnormal_thermal_nociception	1.38146600
46	MP0010386_abnormal_urinary_bladder	1.37930521
47	MP0002735_abnormal_chemical_nociception	1.35921333
48	MP0002572_abnormal_emotion/affect_behav	1.33232098
49	MP0001970_abnormal_pain_threshold	1.31832339
50	MP0001529_abnormal_vocalization	1.30480551
51	MP0002064_seizures	1.24800464
52	MP0002163_abnormal_gland_morphology	1.23742672
53	MP0005389_reproductive_system_phenotype	1.20681348
54	MP0002557_abnormal_social/conspecific_i	1.19802931
55	MP0002234_abnormal_pharynx_morphology	1.17937967
56	MP0005386_behavior/neurological_phenoty	1.17497748
57	MP0004924_abnormal_behavior	1.17497748
58	MP0001485_abnormal_pinna_reflex	1.16624454
59	MP0002095_abnormal_skin_pigmentation	1.15078727
60	MP0004742_abnormal_vestibular_system	1.12138164
61	MP0008789_abnormal_olfactory_epithelium	1.11973081
62	MP0002067_abnormal_sensory_capabilities	1.10860632
63	MP0005379_endocrine/exocrine_gland_phen	1.08295203
64	MP0002928_abnormal_bile_duct	1.06974360
65	MP0002277_abnormal_respiratory_mucosa	1.06701703
66	MP0005195_abnormal_posterior_eye	1.05696492
67	MP0001919_abnormal_reproductive_system	1.05128939
68	MP0003718_maternal_effect	1.05079551
69	MP0003635_abnormal_synaptic_transmissio	1.04632453
70	MP0002160_abnormal_reproductive_system	1.03041064
71	MP0001905_abnormal_dopamine_level	1.02633361
72	MP0002063_abnormal_learning/memory/cond	1.01191243
73	MP0005410_abnormal_fertilization	1.00002504
74	MP0004145_abnormal_muscle_electrophysio	0.99574247
75	MP0000230_abnormal_systemic_arterial	0.98097024
76	MP0001324_abnormal_eye_pigmentation	0.97714322
77	MP0002734_abnormal_mechanical_nocicepti	0.96893115
78	MP0003252_abnormal_bile_duct	0.96892373
79	MP0008058_abnormal_DNA_repair	0.94638540
80	MP0005085_abnormal_gallbladder_physiolo	0.94483028
81	MP0000015_abnormal_ear_pigmentation	0.92203576
82	MP0002752_abnormal_somatic_nervous	0.90707442
83	MP0008995_early_reproductive_senescence	0.88940842
84	MP0002229_neurodegeneration	0.86116664
85	MP0003698_abnormal_male_reproductive	0.83877032
86	MP0002909_abnormal_adrenal_gland	0.83708867
87	MP0008775_abnormal_heart_ventricle	0.83146496
88	MP0005332_abnormal_amino_acid	0.82808314
89	MP0001502_abnormal_circadian_rhythm	0.81742804
90	MP0000778_abnormal_nervous_system	0.79677465
91	MP0003121_genomic_imprinting	0.79005694
92	MP0002751_abnormal_autonomic_nervous	0.78532740
93	MP0000647_abnormal_sebaceous_gland	0.78038916
94	MP0001764_abnormal_homeostasis	0.77519043
95	MP0002184_abnormal_innervation	0.77083313
96	MP0000026_abnormal_inner_ear	0.76629998
97	MP0005167_abnormal_blood-brain_barrier	0.76215542
98	MP0010329_abnormal_lipoprotein_level	0.74635790
99	MP0002693_abnormal_pancreas_physiology	0.74580071
100	MP0001963_abnormal_hearing_physiology	0.74378192

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.63896943
2	Pancreatic fibrosis (HP:0100732)	4.26649846
3	Abnormality of midbrain morphology (HP:0002418)	4.22095609
4	Molar tooth sign on MRI (HP:0002419)	4.22095609
5	Congenital stationary night blindness (HP:0007642)	4.01853320
6	True hermaphroditism (HP:0010459)	3.97622208
7	Nephronophthisis (HP:0000090)	3.80423229
8	Type II lissencephaly (HP:0007260)	3.77795562
9	Abnormality of the renal medulla (HP:0100957)	3.34817211
10	Abnormality of the renal cortex (HP:0011035)	3.33206266
11	Medial flaring of the eyebrow (HP:0010747)	3.33131092
12	Attenuation of retinal blood vessels (HP:0007843)	3.02934120
13	Hyperventilation (HP:0002883)	3.01736704
14	Pendular nystagmus (HP:0012043)	2.90861750
15	Abolished electroretinogram (ERG) (HP:0000550)	2.90385205
16	Cystic liver disease (HP:0006706)	2.83948724
17	Tubular atrophy (HP:0000092)	2.78449665
18	Chronic hepatic failure (HP:0100626)	2.76423231
19	3-Methylglutaconic aciduria (HP:0003535)	2.74083268
20	Abnormal rod and cone electroretinograms (HP:0008323)	2.73923186
21	Abnormal drinking behavior (HP:0030082)	2.69137919
22	Polydipsia (HP:0001959)	2.69137919
23	Gait imbalance (HP:0002141)	2.68433184
24	Cerebellar dysplasia (HP:0007033)	2.65091015
25	Abnormality of alanine metabolism (HP:0010916)	2.64503052
26	Hyperalaninemia (HP:0003348)	2.64503052
27	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.64503052
28	Congenital primary aphakia (HP:0007707)	2.57488068
29	Acute necrotizing encephalopathy (HP:0006965)	2.53262691
30	Gaze-evoked nystagmus (HP:0000640)	2.52457242
31	Increased corneal curvature (HP:0100692)	2.51923531
32	Keratoconus (HP:0000563)	2.51923531
33	Inability to walk (HP:0002540)	2.47325053
34	Lissencephaly (HP:0001339)	2.44880468
35	Renal cortical cysts (HP:0000803)	2.43896684
36	Decreased central vision (HP:0007663)	2.42928140
37	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.42898356
38	Nephrogenic diabetes insipidus (HP:0009806)	2.41265522
39	Mitochondrial inheritance (HP:0001427)	2.36712085
40	Progressive inability to walk (HP:0002505)	2.34690984
41	Bile duct proliferation (HP:0001408)	2.32182456
42	Abnormal biliary tract physiology (HP:0012439)	2.32182456
43	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.30448805
44	Increased CSF lactate (HP:0002490)	2.28252695
45	Sclerocornea (HP:0000647)	2.26820206
46	Progressive macrocephaly (HP:0004481)	2.25045579
47	Absent/shortened dynein arms (HP:0200106)	2.24179846
48	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.24179846
49	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.23593406
50	Acute encephalopathy (HP:0006846)	2.23420699
51	Congenital hepatic fibrosis (HP:0002612)	2.22028120
52	Anencephaly (HP:0002323)	2.19445183
53	Progressive cerebellar ataxia (HP:0002073)	2.19186859
54	Genital tract atresia (HP:0001827)	2.17796837
55	Abnormality of the pons (HP:0007361)	2.16625767
56	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.14660367
57	Abnormal mitochondria in muscle tissue (HP:0008316)	2.12676084
58	Polyuria (HP:0000103)	2.10715304
59	Methylmalonic acidemia (HP:0002912)	2.10030077
60	Abnormal respiratory motile cilium morphology (HP:0005938)	2.09425824
61	Abnormal respiratory epithelium morphology (HP:0012253)	2.09425824
62	Broad-based gait (HP:0002136)	2.09213002
63	Decreased circulating renin level (HP:0003351)	2.07926130
64	Hypoplasia of the pons (HP:0012110)	2.07514231
65	Vaginal atresia (HP:0000148)	2.05693014
66	Optic disc pallor (HP:0000543)	2.04597054
67	Large for gestational age (HP:0001520)	2.04036154
68	Hepatocellular necrosis (HP:0001404)	2.04023356
69	Hypothermia (HP:0002045)	2.01622652
70	Male pseudohermaphroditism (HP:0000037)	2.00967539
71	Bony spicule pigmentary retinopathy (HP:0007737)	2.00778686
72	Intestinal atresia (HP:0011100)	2.00691495
73	Hemiparesis (HP:0001269)	1.97025078
74	Optic nerve hypoplasia (HP:0000609)	1.96700351
75	Severe muscular hypotonia (HP:0006829)	1.95667703
76	Concave nail (HP:0001598)	1.94762582
77	Methylmalonic aciduria (HP:0012120)	1.93400407
78	Postaxial foot polydactyly (HP:0001830)	1.93022816
79	Hepatic necrosis (HP:0002605)	1.91997107
80	Chorioretinal atrophy (HP:0000533)	1.91946824
81	Fair hair (HP:0002286)	1.90906954
82	Pachygyria (HP:0001302)	1.90721233
83	Focal motor seizures (HP:0011153)	1.90150026
84	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.90066652
85	Furrowed tongue (HP:0000221)	1.88819377
86	Febrile seizures (HP:0002373)	1.87441350
87	Congenital sensorineural hearing impairment (HP:0008527)	1.86538263
88	Absent speech (HP:0001344)	1.84977525
89	Poor coordination (HP:0002370)	1.84960515
90	Stomach cancer (HP:0012126)	1.84329937
91	Postaxial hand polydactyly (HP:0001162)	1.84322421
92	Short tibia (HP:0005736)	1.84014198
93	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.83687436
94	Hypoplasia of the fovea (HP:0007750)	1.83687436
95	Retinal dysplasia (HP:0007973)	1.83156435
96	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.79327386
97	Abnormality of macular pigmentation (HP:0008002)	1.76941685
98	Congenital, generalized hypertrichosis (HP:0004540)	1.76580973
99	Retinitis pigmentosa (HP:0000510)	1.74798008
100	Increased serum lactate (HP:0002151)	1.73130287

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.25633812
2	MAP4K2	3.33453095
3	ADRBK2	3.15404004
4	BMPR1B	2.86837682
5	WNK3	2.84343646
6	ZAK	2.80976957
7	GRK1	2.66622611
8	WNK4	2.51696391
9	NUAK1	2.47410904
10	PINK1	2.44033119
11	TLK1	2.13467427
12	MAPK13	2.12385064
13	TAOK3	2.05957671
14	ACVR1B	2.04136612
15	CASK	1.90791960
16	MAP3K4	1.81630430
17	STK39	1.70955060
18	INSRR	1.70172304
19	TXK	1.63923055
20	TRIM28	1.59037862
21	OXSR1	1.53221734
22	DAPK2	1.40716571
23	MKNK2	1.24130789
24	ADRBK1	1.17706177
25	PAK3	1.17578287
26	MAP2K7	1.17504721
27	MARK1	1.17222033
28	DYRK2	1.16438212
29	CAMKK2	1.13652475
30	TNIK	1.12501031
31	BCKDK	1.11161391
32	STK38L	1.08658916
33	PLK2	1.07624412
34	PRKCE	1.00260066
35	CSNK1G2	0.98111880
36	NTRK3	0.98008167
37	VRK1	0.91135110
38	CSNK1G3	0.90595201
39	PRKCG	0.90040155
40	CSNK1G1	0.89883602
41	TGFBR1	0.87991010
42	BCR	0.87445518
43	MAPKAPK3	0.84921645
44	PHKG2	0.83980835
45	PHKG1	0.83980835
46	EPHA4	0.78170145
47	CSNK1A1L	0.77312305
48	PIK3CA	0.71224493
49	PTK2B	0.69445916
50	PRKCQ	0.68217610
51	TNK2	0.67771118
52	ERBB3	0.58898188
53	TIE1	0.58771609
54	FGFR2	0.58744793
55	NTRK2	0.57964690
56	MAPKAPK5	0.57504393
57	PKN1	0.57334723
58	VRK2	0.57076835
59	MKNK1	0.55768483
60	KIT	0.55538236
61	CAMK2A	0.55521197
62	GRK7	0.54957948
63	PRKCI	0.54886764
64	RPS6KA5	0.53986810
65	PLK4	0.53629990
66	PNCK	0.52200348
67	PLK3	0.50922351
68	NLK	0.49906239
69	CSNK1A1	0.49682673
70	PRKACA	0.49008378
71	BRSK2	0.48550993
72	CAMK1	0.48379426
73	IKBKB	0.48154210
74	TEC	0.47995585
75	STK16	0.47875572
76	MAPK15	0.46848863
77	MST4	0.46580114
78	EIF2AK3	0.46115614
79	STK3	0.45462145
80	IRAK1	0.42668988
81	STK11	0.42621115
82	GRK5	0.38797336
83	CSNK1D	0.38465636
84	PRKCH	0.37943553
85	ITK	0.36957344
86	MAP2K6	0.36846470
87	PRKCA	0.36366718
88	EPHA3	0.34734570
89	TAF1	0.34061702
90	DYRK1A	0.33422338
91	PRKCZ	0.33209348
92	PRKAA1	0.32332099
93	OBSCN	0.32011236
94	NME1	0.31605309
95	ATR	0.31267725
96	PIK3CG	0.30968998
97	SYK	0.29032120
98	PRKG1	0.28372993
99	CAMK2D	0.28164057
100	PRKAA2	0.27745500

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.97208446
2	Linoleic acid metabolism_Homo sapiens_hsa00591	2.73574838
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.61718736
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.31250434
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.30001025
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.28924055
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.28465218
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.27838207
9	Butanoate metabolism_Homo sapiens_hsa00650	2.27621127
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.27406009
11	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.05538930
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.04261795
13	Protein export_Homo sapiens_hsa03060	2.03503744
14	Nicotine addiction_Homo sapiens_hsa05033	1.96076907
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.91815551
16	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.87918008
17	Ether lipid metabolism_Homo sapiens_hsa00565	1.87437977
18	Basal transcription factors_Homo sapiens_hsa03022	1.84542486
19	RNA polymerase_Homo sapiens_hsa03020	1.79298477
20	Selenocompound metabolism_Homo sapiens_hsa00450	1.77356667
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.69685873
22	Parkinsons disease_Homo sapiens_hsa05012	1.69627977
23	Homologous recombination_Homo sapiens_hsa03440	1.54151201
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.50787867
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.47069593
26	Caffeine metabolism_Homo sapiens_hsa00232	1.46779768
27	Propanoate metabolism_Homo sapiens_hsa00640	1.45389453
28	One carbon pool by folate_Homo sapiens_hsa00670	1.32649319
29	Taste transduction_Homo sapiens_hsa04742	1.31619274
30	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.31391501
31	Morphine addiction_Homo sapiens_hsa05032	1.30846389
32	Olfactory transduction_Homo sapiens_hsa04740	1.27183445
33	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.26685617
34	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.25845500
35	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.25169298
36	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.22394576
37	Regulation of autophagy_Homo sapiens_hsa04140	1.19993223
38	RNA degradation_Homo sapiens_hsa03018	1.19424365
39	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.17130740
40	Peroxisome_Homo sapiens_hsa04146	1.16069448
41	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.15739957
42	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.08616240
43	Chemical carcinogenesis_Homo sapiens_hsa05204	1.07358728
44	Huntingtons disease_Homo sapiens_hsa05016	1.06578951
45	ABC transporters_Homo sapiens_hsa02010	1.04774954
46	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.02959012
47	Alzheimers disease_Homo sapiens_hsa05010	1.00929133
48	Serotonergic synapse_Homo sapiens_hsa04726	0.98196334
49	GABAergic synapse_Homo sapiens_hsa04727	0.98149275
50	Retinol metabolism_Homo sapiens_hsa00830	0.96073840
51	Primary immunodeficiency_Homo sapiens_hsa05340	0.94200368
52	Cardiac muscle contraction_Homo sapiens_hsa04260	0.94016046
53	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.92219373
54	Circadian entrainment_Homo sapiens_hsa04713	0.91836498
55	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.91827177
56	Glutamatergic synapse_Homo sapiens_hsa04724	0.90338475
57	Collecting duct acid secretion_Homo sapiens_hsa04966	0.88886252
58	Insulin secretion_Homo sapiens_hsa04911	0.88381726
59	Asthma_Homo sapiens_hsa05310	0.83853664
60	Fat digestion and absorption_Homo sapiens_hsa04975	0.79818702
61	Proteasome_Homo sapiens_hsa03050	0.79698621
62	Glycerolipid metabolism_Homo sapiens_hsa00561	0.78269144
63	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.75753259
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.75160792
65	Type I diabetes mellitus_Homo sapiens_hsa04940	0.72458974
66	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.70150432
67	Sulfur metabolism_Homo sapiens_hsa00920	0.69701637
68	Purine metabolism_Homo sapiens_hsa00230	0.69302929
69	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.69118607
70	Non-homologous end-joining_Homo sapiens_hsa03450	0.68794402
71	Sulfur relay system_Homo sapiens_hsa04122	0.67667611
72	Steroid biosynthesis_Homo sapiens_hsa00100	0.67648017
73	Metabolic pathways_Homo sapiens_hsa01100	0.65670760
74	Salivary secretion_Homo sapiens_hsa04970	0.64486198
75	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.62019036
76	beta-Alanine metabolism_Homo sapiens_hsa00410	0.59741089
77	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.57165780
78	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.56258080
79	Calcium signaling pathway_Homo sapiens_hsa04020	0.55992948
80	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.55611440
81	Histidine metabolism_Homo sapiens_hsa00340	0.55572348
82	Allograft rejection_Homo sapiens_hsa05330	0.55175772
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.55016218
84	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.49720432
85	Dopaminergic synapse_Homo sapiens_hsa04728	0.49532428
86	Pyrimidine metabolism_Homo sapiens_hsa00240	0.49350334
87	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.49278100
88	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.48788268
89	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.47364059
90	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.47110655
91	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.46147461
92	Graft-versus-host disease_Homo sapiens_hsa05332	0.45694389
93	Circadian rhythm_Homo sapiens_hsa04710	0.43617442
94	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.43244012
95	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.40028043
96	Mineral absorption_Homo sapiens_hsa04978	0.37758377
97	Rheumatoid arthritis_Homo sapiens_hsa05323	0.37201583
98	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.36986586
99	Fatty acid degradation_Homo sapiens_hsa00071	0.36624697
100	Long-term depression_Homo sapiens_hsa04730	0.34263824

YWHAQP5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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