YWHAQP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of protein glycosylation (GO:0060049)5.27059584
2platelet dense granule organization (GO:0060155)4.84839120
3positive regulation of T cell cytokine production (GO:0002726)4.54634313
4negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.46487593
5positive regulation of T cell chemotaxis (GO:0010820)4.36980625
6regulation of T cell chemotaxis (GO:0010819)4.36980625
7protein K6-linked ubiquitination (GO:0085020)4.08703149
8response to pheromone (GO:0019236)4.02549421
9retinal cone cell development (GO:0046549)3.92318190
10single strand break repair (GO:0000012)3.89743787
11interferon-gamma production (GO:0032609)3.87147989
12detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.59864702
13eye photoreceptor cell development (GO:0042462)3.59056089
14L-fucose catabolic process (GO:0042355)3.56611650
15fucose catabolic process (GO:0019317)3.56611650
16L-fucose metabolic process (GO:0042354)3.56611650
17negative regulation of JUN kinase activity (GO:0043508)3.55824244
18photoreceptor cell development (GO:0042461)3.55613143
19piRNA metabolic process (GO:0034587)3.44315129
20protein K11-linked deubiquitination (GO:0035871)3.41586120
21fibroblast migration (GO:0010761)3.37063744
22C4-dicarboxylate transport (GO:0015740)3.36965084
23lactate metabolic process (GO:0006089)3.33643784
24axoneme assembly (GO:0035082)3.32693752
25DNA ligation (GO:0006266)3.28018231
26positive regulation of type 2 immune response (GO:0002830)3.18520037
27negative regulation of DNA-dependent DNA replication (GO:2000104)3.13628863
28positive regulation of alpha-beta T cell proliferation (GO:0046641)3.11717996
29DNA double-strand break processing (GO:0000729)3.11177845
30aldehyde catabolic process (GO:0046185)3.08645714
31activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.07255166
32protein heterotetramerization (GO:0051290)3.05512757
33intestinal epithelial cell development (GO:0060576)3.04904018
34positive regulation of transforming growth factor beta production (GO:0071636)3.04243264
35intra-S DNA damage checkpoint (GO:0031573)3.00316990
36DNA damage response, detection of DNA damage (GO:0042769)2.96854019
37cellular response to interleukin-15 (GO:0071350)2.94590611
38amine catabolic process (GO:0009310)2.93556972
39cellular biogenic amine catabolic process (GO:0042402)2.93556972
40inner ear receptor stereocilium organization (GO:0060122)2.93124936
41water-soluble vitamin biosynthetic process (GO:0042364)2.93077566
42regulation of Rac protein signal transduction (GO:0035020)2.92066851
43pyrimidine nucleobase catabolic process (GO:0006208)2.90705691
44DNA methylation involved in gamete generation (GO:0043046)2.88770946
45regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.88131582
46sympathetic nervous system development (GO:0048485)2.86172842
47phasic smooth muscle contraction (GO:0014821)2.84586347
48glial cell proliferation (GO:0014009)2.81304435
49regulation of T cell cytokine production (GO:0002724)2.80663701
50iron-sulfur cluster assembly (GO:0016226)2.79087446
51metallo-sulfur cluster assembly (GO:0031163)2.79087446
52regulation of glucokinase activity (GO:0033131)2.76800258
53regulation of hexokinase activity (GO:1903299)2.76800258
54protein localization to cilium (GO:0061512)2.75630822
55detection of light stimulus involved in sensory perception (GO:0050962)2.75620484
56detection of light stimulus involved in visual perception (GO:0050908)2.75620484
57presynaptic membrane assembly (GO:0097105)2.74372498
58kynurenine metabolic process (GO:0070189)2.72976289
59peristalsis (GO:0030432)2.71805208
60respiratory chain complex IV assembly (GO:0008535)2.70408964
61anterograde synaptic vesicle transport (GO:0048490)2.68927132
62indolalkylamine metabolic process (GO:0006586)2.68716321
63positive regulation of T-helper 1 type immune response (GO:0002827)2.67317799
64negative regulation of transcription regulatory region DNA binding (GO:2000678)2.67154044
65acrosome assembly (GO:0001675)2.66263550
66recombinational repair (GO:0000725)2.64709859
67tryptophan catabolic process (GO:0006569)2.64085349
68indole-containing compound catabolic process (GO:0042436)2.64085349
69indolalkylamine catabolic process (GO:0046218)2.64085349
70double-strand break repair via homologous recombination (GO:0000724)2.61334079
71mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.61247653
72positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.61247653
73pericardium development (GO:0060039)2.57459920
74keratinocyte development (GO:0003334)2.56932451
75branched-chain amino acid catabolic process (GO:0009083)2.56126735
76tryptophan metabolic process (GO:0006568)2.55692659
77adenosine metabolic process (GO:0046085)2.54279039
78regulation of T-helper 1 type immune response (GO:0002825)2.52344355
79regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.52095459
80somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.51947721
81somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.51947721
82isotype switching (GO:0045190)2.51947721
83cilium morphogenesis (GO:0060271)2.50419318
84retinal rod cell development (GO:0046548)2.49672137
85regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.48490281
86regulation of mitotic spindle checkpoint (GO:1903504)2.48490281
87reciprocal DNA recombination (GO:0035825)2.47591650
88reciprocal meiotic recombination (GO:0007131)2.47591650
89regulation of lymphocyte chemotaxis (GO:1901623)2.47562872
90gene silencing by RNA (GO:0031047)2.46428812
91non-recombinational repair (GO:0000726)2.43580314
92double-strand break repair via nonhomologous end joining (GO:0006303)2.43580314
93regulation of meiosis I (GO:0060631)2.42132199
94histone H2A acetylation (GO:0043968)2.41381600
95nucleobase catabolic process (GO:0046113)2.40010120
96intraciliary transport (GO:0042073)2.38887504
97mannosylation (GO:0097502)2.37924898
98preassembly of GPI anchor in ER membrane (GO:0016254)2.36835934
99cytochrome complex assembly (GO:0017004)2.36087506
100regulation of relaxation of muscle (GO:1901077)2.35333330

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.76939108
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.06441795
3ZNF274_21170338_ChIP-Seq_K562_Hela3.03912327
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.84717507
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.83433633
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.83046883
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.59162616
8VDR_22108803_ChIP-Seq_LS180_Human2.51052547
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.37607567
10IGF1R_20145208_ChIP-Seq_DFB_Human2.37303707
11GBX2_23144817_ChIP-Seq_PC3_Human2.25958657
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.21449596
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.18117334
14P300_19829295_ChIP-Seq_ESCs_Human2.09154186
15FUS_26573619_Chip-Seq_HEK293_Human2.07031506
16AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.00328375
17SUZ12_27294783_Chip-Seq_NPCs_Mouse1.98465067
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.96401157
19RBPJ_22232070_ChIP-Seq_NCS_Mouse1.95589339
20EWS_26573619_Chip-Seq_HEK293_Human1.92297077
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87543658
22EZH2_27294783_Chip-Seq_NPCs_Mouse1.87421351
23NFE2_27457419_Chip-Seq_LIVER_Mouse1.83266512
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.78923033
25ER_23166858_ChIP-Seq_MCF-7_Human1.77804285
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75694658
27BCAT_22108803_ChIP-Seq_LS180_Human1.66919961
28PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66586701
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.66398705
30ELK1_19687146_ChIP-ChIP_HELA_Human1.65145111
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61221938
32CBP_20019798_ChIP-Seq_JUKART_Human1.58269748
33IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.58269748
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.57145552
35SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56787367
36TAF15_26573619_Chip-Seq_HEK293_Human1.56773320
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.54567158
38CRX_20693478_ChIP-Seq_RETINA_Mouse1.50622917
39NANOG_18555785_Chip-Seq_ESCs_Mouse1.50291963
40SMAD4_21799915_ChIP-Seq_A2780_Human1.49167629
41CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.48463261
42TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48434288
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47032079
44P53_22387025_ChIP-Seq_ESCs_Mouse1.46649852
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.42878534
46POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42135612
47TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42135612
48IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40463632
49EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.40235548
50STAT3_23295773_ChIP-Seq_U87_Human1.38925585
51AR_25329375_ChIP-Seq_VCAP_Human1.36459606
52E2F1_18555785_Chip-Seq_ESCs_Mouse1.35793827
53NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35102075
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34310908
55FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33087358
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33062346
57P300_18555785_Chip-Seq_ESCs_Mouse1.32714289
58OCT4_21477851_ChIP-Seq_ESCs_Mouse1.30718425
59SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.30328923
60TCF4_22108803_ChIP-Seq_LS180_Human1.29578430
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28773146
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28684937
63KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28433960
64CMYC_18555785_Chip-Seq_ESCs_Mouse1.28433241
65SUZ12_18555785_Chip-Seq_ESCs_Mouse1.27046535
66NANOG_19829295_ChIP-Seq_ESCs_Human1.26284943
67SOX2_19829295_ChIP-Seq_ESCs_Human1.26284943
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24834349
69CDX2_22108803_ChIP-Seq_LS180_Human1.23223612
70TCF4_23295773_ChIP-Seq_U87_Human1.22929700
71RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22920157
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22816210
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22765454
74STAT3_18555785_Chip-Seq_ESCs_Mouse1.22565895
75TP53_18474530_ChIP-ChIP_U2OS_Human1.21990965
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21215666
77OCT4_18555785_Chip-Seq_ESCs_Mouse1.21077086
78HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20755243
79EGR1_23403033_ChIP-Seq_LIVER_Mouse1.18707093
80EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.18684223
81CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18408530
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.18042878
83AUTS2_25519132_ChIP-Seq_293T-REX_Human1.17402233
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17317680
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.16655612
86EST1_17652178_ChIP-ChIP_JURKAT_Human1.15008265
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14515694
88PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12567246
89FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11974678
90POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11368068
91SOX2_18555785_Chip-Seq_ESCs_Mouse1.10463863
92FLI1_21867929_ChIP-Seq_TH2_Mouse1.10050277
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.09926110
94BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08302526
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08088699
96NMYC_18555785_Chip-Seq_ESCs_Mouse1.07771340
97RUNX2_22187159_ChIP-Seq_PCA_Human1.06860583
98P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04687657
99FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03380697
100FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01787471

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.77800888
2MP0000372_irregular_coat_pigmentation2.45775904
3MP0005646_abnormal_pituitary_gland2.38767746
4MP0008789_abnormal_olfactory_epithelium2.35968981
5MP0005253_abnormal_eye_physiology2.31915753
6MP0008058_abnormal_DNA_repair2.28651292
7MP0002653_abnormal_ependyma_morphology2.23967623
8MP0002736_abnormal_nociception_after2.22733713
9MP0000427_abnormal_hair_cycle2.21074765
10MP0003880_abnormal_central_pattern2.17860637
11MP0003283_abnormal_digestive_organ2.16880543
12MP0002102_abnormal_ear_morphology2.16132320
13MP0000613_abnormal_salivary_gland2.10409625
14MP0003786_premature_aging1.99821893
15MP0006054_spinal_hemorrhage1.95071438
16MP0001501_abnormal_sleep_pattern1.94051454
17MP0003787_abnormal_imprinting1.89842980
18MP0005551_abnormal_eye_electrophysiolog1.88725778
19MP0008872_abnormal_physiological_respon1.88181348
20MP0002163_abnormal_gland_morphology1.85335085
21MP0003950_abnormal_plasma_membrane1.78511254
22MP0005645_abnormal_hypothalamus_physiol1.77376594
23MP0002751_abnormal_autonomic_nervous1.71559518
24MP0010094_abnormal_chromosome_stability1.69438160
25MP0000569_abnormal_digit_pigmentation1.68585999
26MP0002876_abnormal_thyroid_physiology1.63331410
27MP0003943_abnormal_hepatobiliary_system1.59668481
28MP0001968_abnormal_touch/_nociception1.57694808
29MP0002233_abnormal_nose_morphology1.55709733
30MP0001529_abnormal_vocalization1.55561362
31MP0005670_abnormal_white_adipose1.54364841
32MP0002254_reproductive_system_inflammat1.53422110
33MP0003195_calcinosis1.50080085
34MP0001486_abnormal_startle_reflex1.49961545
35MP0005310_abnormal_salivary_gland1.48792037
36MP0002282_abnormal_trachea_morphology1.46519348
37MP0004134_abnormal_chest_morphology1.44981136
38MP0008995_early_reproductive_senescence1.44239418
39MP0001485_abnormal_pinna_reflex1.41447569
40MP0006072_abnormal_retinal_apoptosis1.38618328
41MP0005084_abnormal_gallbladder_morpholo1.38481056
42MP0005174_abnormal_tail_pigmentation1.33884741
43MP0001764_abnormal_homeostasis1.31400221
44MP0004742_abnormal_vestibular_system1.30158725
45MP0005379_endocrine/exocrine_gland_phen1.29659666
46MP0002938_white_spotting1.29325568
47MP0003718_maternal_effect1.29111102
48MP0005671_abnormal_response_to1.25559196
49MP0000516_abnormal_urinary_system1.24701730
50MP0005367_renal/urinary_system_phenotyp1.24701730
51MP0005394_taste/olfaction_phenotype1.24614942
52MP0005499_abnormal_olfactory_system1.24614942
53MP0008007_abnormal_cellular_replicative1.20383089
54MP0001984_abnormal_olfaction1.19902901
55MP0002006_tumorigenesis1.18174813
56MP0000647_abnormal_sebaceous_gland1.17314774
57MP0002108_abnormal_muscle_morphology1.13529262
58MP0005647_abnormal_sex_gland1.09910367
59MP0005503_abnormal_tendon_morphology1.07935741
60MP0005085_abnormal_gallbladder_physiolo1.07755153
61MP0003755_abnormal_palate_morphology1.06721239
62MP0009697_abnormal_copulation1.06584541
63MP0004142_abnormal_muscle_tone1.06441210
64MP0003252_abnormal_bile_duct1.06266218
65MP0009745_abnormal_behavioral_response1.05844832
66MP0000639_abnormal_adrenal_gland1.04019707
67MP0006276_abnormal_autonomic_nervous1.03139511
68MP0004883_abnormal_blood_vessel1.00230366
69MP0003937_abnormal_limbs/digits/tail_de0.98266595
70MP0002095_abnormal_skin_pigmentation0.97507977
71MP0001119_abnormal_female_reproductive0.94724480
72MP0008875_abnormal_xenobiotic_pharmacok0.93158007
73MP0004133_heterotaxia0.90522881
74MP0000013_abnormal_adipose_tissue0.86784128
75MP0005360_urolithiasis0.86755088
76MP0000383_abnormal_hair_follicle0.86679296
77MP0002272_abnormal_nervous_system0.86229160
78MP0005395_other_phenotype0.85299096
79MP0001929_abnormal_gametogenesis0.85161044
80MP0002557_abnormal_social/conspecific_i0.84586916
81MP0008057_abnormal_DNA_replication0.83982092
82MP0003698_abnormal_male_reproductive0.80602421
83MP0000631_abnormal_neuroendocrine_gland0.80398463
84MP0003121_genomic_imprinting0.80116842
85MP0002734_abnormal_mechanical_nocicepti0.79960442
86MP0005000_abnormal_immune_tolerance0.77125755
87MP0000371_diluted_coat_color0.75278842
88MP0000778_abnormal_nervous_system0.74176831
89MP0005167_abnormal_blood-brain_barrier0.73196081
90MP0002168_other_aberrant_phenotype0.72252291
91MP0000653_abnormal_sex_gland0.71343570
92MP0005391_vision/eye_phenotype0.70531279
93MP0003646_muscle_fatigue0.68446312
94MP0000026_abnormal_inner_ear0.68331481
95MP0001188_hyperpigmentation0.65757666
96MP0003119_abnormal_digestive_system0.64028304
97MP0009765_abnormal_xenobiotic_induced0.64026909
98MP0004924_abnormal_behavior0.63788031
99MP0005386_behavior/neurological_phenoty0.63788031
100MP0008873_increased_physiological_sensi0.63457507

Predicted human phenotypes

RankGene SetZ-score
1Type II lissencephaly (HP:0007260)4.15316752
2Molar tooth sign on MRI (HP:0002419)3.84860592
3Abnormality of midbrain morphology (HP:0002418)3.84860592
4Abnormality of the labia minora (HP:0012880)3.83658211
5True hermaphroditism (HP:0010459)3.75415438
6Pancreatic cysts (HP:0001737)3.74889086
7Retinal dysplasia (HP:0007973)3.54425355
8Amyotrophic lateral sclerosis (HP:0007354)3.35215210
9Calf muscle hypertrophy (HP:0008981)3.19283180
10Chronic hepatic failure (HP:0100626)3.10190657
11Pancreatic fibrosis (HP:0100732)3.06588901
12Gaze-evoked nystagmus (HP:0000640)2.98403238
13Metaphyseal dysplasia (HP:0100255)2.98211653
14Abnormality of the lower motor neuron (HP:0002366)2.96666485
15Stomach cancer (HP:0012126)2.94411122
16Thyroiditis (HP:0100646)2.82463303
17Severe combined immunodeficiency (HP:0004430)2.81262352
18Abnormality of lateral ventricle (HP:0030047)2.75405955
19Optic neuritis (HP:0100653)2.72761561
20Retrobulbar optic neuritis (HP:0100654)2.72761561
21Muscle hypertrophy of the lower extremities (HP:0008968)2.71856093
22Hypoplastic ischia (HP:0003175)2.70707279
23Lissencephaly (HP:0001339)2.66663548
24Absent rod-and cone-mediated responses on ERG (HP:0007688)2.64951446
25Abnormality of the astrocytes (HP:0100707)2.57485842
26Astrocytoma (HP:0009592)2.57485842
27Abnormality of the ischium (HP:0003174)2.56269350
28Nephronophthisis (HP:0000090)2.54316252
29Hyperventilation (HP:0002883)2.45125305
30Abnormality of DNA repair (HP:0003254)2.44815012
31Congenital stationary night blindness (HP:0007642)2.40209128
32Hypoproteinemia (HP:0003075)2.35757510
333-Methylglutaconic aciduria (HP:0003535)2.33328524
34Aplasia/Hypoplasia of the tongue (HP:0010295)2.32245429
35Bifid tongue (HP:0010297)2.26883662
36Glioma (HP:0009733)2.19743454
37Abnormality of the phalanges of the 2nd finger (HP:0009541)2.17854979
38Intestinal atresia (HP:0011100)2.16556241
39Abnormality of the renal medulla (HP:0100957)2.16027061
40Aplasia/Hypoplasia involving the musculature (HP:0001460)2.15074059
41Type I transferrin isoform profile (HP:0003642)2.12697694
42Aplasia/Hypoplasia of the tibia (HP:0005772)2.12562319
43Attenuation of retinal blood vessels (HP:0007843)2.11404818
44Cystic liver disease (HP:0006706)2.10650534
45Cutaneous melanoma (HP:0012056)2.08044956
46Medial flaring of the eyebrow (HP:0010747)2.06039264
47Abnormal rod and cone electroretinograms (HP:0008323)2.05494587
48Abnormality of eosinophils (HP:0001879)2.04269080
49Small hand (HP:0200055)2.03915918
50Abnormal delayed hypersensitivity skin test (HP:0002963)2.03744660
51Occipital encephalocele (HP:0002085)2.02235122
52Aplasia/hypoplasia of the uterus (HP:0008684)2.00034854
53Neuroendocrine neoplasm (HP:0100634)1.99676549
54Posterior subcapsular cataract (HP:0007787)1.98338443
55Hypoplasia of the uterus (HP:0000013)1.98289781
56Anencephaly (HP:0002323)1.98164382
57Dyskinesia (HP:0100660)1.97431840
58Abolished electroretinogram (ERG) (HP:0000550)1.97066705
59Follicular hyperkeratosis (HP:0007502)1.96960920
60Disproportionate short-trunk short stature (HP:0003521)1.96934359
61Orchitis (HP:0100796)1.96444453
62Pendular nystagmus (HP:0012043)1.96048522
63Short tibia (HP:0005736)1.94017973
64Absent speech (HP:0001344)1.92716644
65Atrophy/Degeneration involving motor neurons (HP:0007373)1.90408867
66Decreased central vision (HP:0007663)1.89718928
67Hemiparesis (HP:0001269)1.89515526
68Dyschromatopsia (HP:0007641)1.89433335
69Combined immunodeficiency (HP:0005387)1.88949735
70Sloping forehead (HP:0000340)1.88038328
71Keratitis (HP:0000491)1.87654805
72Hypothermia (HP:0002045)1.85130111
73Fibular aplasia (HP:0002990)1.84920402
74Increased corneal curvature (HP:0100692)1.84729372
75Keratoconus (HP:0000563)1.84729372
76Keratoconjunctivitis (HP:0001096)1.84348197
77Fair hair (HP:0002286)1.83052934
78Hyperglycinemia (HP:0002154)1.79325947
79Pheochromocytoma (HP:0002666)1.79269843
80Preaxial hand polydactyly (HP:0001177)1.78258813
81Hypoplastic iliac wings (HP:0002866)1.77905609
82Postaxial hand polydactyly (HP:0001162)1.76549214
83Postaxial foot polydactyly (HP:0001830)1.76496896
84Dandy-Walker malformation (HP:0001305)1.75550590
85Tubular atrophy (HP:0000092)1.72917277
86Long clavicles (HP:0000890)1.71217016
87Febrile seizures (HP:0002373)1.69490041
88Morphological abnormality of the pyramidal tract (HP:0002062)1.68260447
89Chronic diarrhea (HP:0002028)1.68084043
90Ulnar claw (HP:0001178)1.67853135
91Neonatal respiratory distress (HP:0002643)1.64916282
92Oculomotor apraxia (HP:0000657)1.64724742
93Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.64597076
94Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.64096435
95Sclerocornea (HP:0000647)1.64055114
96Keratoconjunctivitis sicca (HP:0001097)1.63715080
97Albinism (HP:0001022)1.63407542
98Ependymoma (HP:0002888)1.63094576
99Abnormality of aspartate family amino acid metabolism (HP:0010899)1.62777319
100Abnormality of chromosome stability (HP:0003220)1.62187575

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.84586192
2PDK24.52371417
3TRIM284.07316608
4MST42.81641338
5BCR2.80481582
6FRK2.60596328
7BRSK22.56730463
8WNK32.39901920
9NUAK12.33488255
10CASK2.19815204
11CDK192.14912267
12EIF2AK32.04249373
13STK392.01714242
14SIK31.88261188
15PAK31.52388917
16MKNK21.50785860
17OXSR11.44399334
18GRK11.43784242
19NEK91.42495446
20TNIK1.40780432
21MAPK131.40052763
22WEE11.38357157
23ERBB31.38308355
24MAP3K41.37450511
25TAOK31.37106410
26ZAK1.36873286
27MAP3K121.35972519
28NEK61.33629592
29PRKD31.33051334
30EIF2AK11.28994607
31PLK21.28744471
32TXK1.17743895
33BCKDK1.15083542
34ADRBK21.14187134
35MARK11.09897642
36PIK3CG1.07512256
37CSNK1G11.06436166
38BMPR1B1.01490877
39EIF2AK21.00981293
40WNK40.98662669
41BRSK10.98502665
42MINK10.95373377
43FER0.91414046
44CSNK1G20.91229270
45TNK20.90819648
46CSNK1G30.87577192
47PBK0.87525900
48PINK10.86791636
49ERBB40.84691747
50CSNK1A1L0.84179221
51SRPK10.84145272
52PRKCE0.80346600
53MKNK10.73353721
54PLK30.71521483
55VRK10.71280298
56DYRK30.70476283
57NEK10.69366945
58ACVR1B0.68754899
59PIK3CA0.68568746
60TSSK60.64875422
61NTRK30.59590488
62DAPK10.57650856
63MUSK0.56300203
64VRK20.53820480
65KSR10.53340059
66MAP2K70.53191685
67GRK70.53011081
68CCNB10.52669416
69DYRK1A0.51859700
70INSRR0.50980165
71PTK2B0.49632648
72ABL10.48515284
73STK38L0.48455722
74PKN10.47933356
75TGFBR20.46320102
76MAP2K10.46166654
77PRKCQ0.45627413
78EPHA40.44487410
79STK100.44258057
80MAPKAPK30.42313001
81NME10.42208472
82ROCK10.41225565
83RAF10.40143050
84PLK10.37397455
85BMPR20.36315646
86MYLK0.33650395
87NLK0.32750591
88PRKCI0.32586247
89CAMK2D0.32453242
90TEC0.32017484
91DYRK20.31323416
92IKBKB0.29669928
93MAP3K20.28945225
94PRKD20.28780367
95ATM0.28028100
96NTRK20.27877872
97GRK50.27797558
98PRKCG0.27576165
99CSNK1A10.27304692
100CSNK1D0.27072534

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.38570729
2Non-homologous end-joining_Homo sapiens_hsa034503.25573726
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.06775430
4Proteasome_Homo sapiens_hsa030502.87007047
5Phototransduction_Homo sapiens_hsa047442.50169217
6Basal transcription factors_Homo sapiens_hsa030222.46292012
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.45298245
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.38691864
9Butanoate metabolism_Homo sapiens_hsa006502.30356811
10Propanoate metabolism_Homo sapiens_hsa006402.24119225
11RNA polymerase_Homo sapiens_hsa030202.09217986
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.02063558
13Primary immunodeficiency_Homo sapiens_hsa053401.80956180
14Homologous recombination_Homo sapiens_hsa034401.79082866
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.67355117
16Tryptophan metabolism_Homo sapiens_hsa003801.65507163
17Olfactory transduction_Homo sapiens_hsa047401.62875430
18Circadian rhythm_Homo sapiens_hsa047101.62319720
19Fanconi anemia pathway_Homo sapiens_hsa034601.56309778
20Linoleic acid metabolism_Homo sapiens_hsa005911.55773149
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.55481975
22Pentose phosphate pathway_Homo sapiens_hsa000301.49522390
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.47448357
24Fatty acid degradation_Homo sapiens_hsa000711.47336608
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.47218727
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46930805
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.30562703
28Nitrogen metabolism_Homo sapiens_hsa009101.29172446
29Fatty acid metabolism_Homo sapiens_hsa012121.28364631
30Regulation of autophagy_Homo sapiens_hsa041401.27053150
31RNA degradation_Homo sapiens_hsa030181.25350807
32Ether lipid metabolism_Homo sapiens_hsa005651.23899491
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16992572
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15757448
35Fatty acid elongation_Homo sapiens_hsa000621.11302946
36Chemical carcinogenesis_Homo sapiens_hsa052041.10515568
37Caffeine metabolism_Homo sapiens_hsa002321.08609034
38Glycerolipid metabolism_Homo sapiens_hsa005611.06857027
39Peroxisome_Homo sapiens_hsa041461.04707139
40Nucleotide excision repair_Homo sapiens_hsa034201.04391237
41Nicotine addiction_Homo sapiens_hsa050331.01243399
42beta-Alanine metabolism_Homo sapiens_hsa004101.00826119
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99245593
44Pyrimidine metabolism_Homo sapiens_hsa002400.97305275
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93959279
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93912208
47Legionellosis_Homo sapiens_hsa051340.89077578
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87715232
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85785275
50Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84467483
51Retinol metabolism_Homo sapiens_hsa008300.84325847
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80596419
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80284983
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.75972550
55Fat digestion and absorption_Homo sapiens_hsa049750.75783088
56Selenocompound metabolism_Homo sapiens_hsa004500.75580544
57One carbon pool by folate_Homo sapiens_hsa006700.74480179
58Taste transduction_Homo sapiens_hsa047420.71590150
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70548340
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70454433
61Steroid biosynthesis_Homo sapiens_hsa001000.70443930
62Parkinsons disease_Homo sapiens_hsa050120.69352771
63Dorso-ventral axis formation_Homo sapiens_hsa043200.67768421
64Oxidative phosphorylation_Homo sapiens_hsa001900.67493131
65Lysine degradation_Homo sapiens_hsa003100.67006264
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65529551
67Hedgehog signaling pathway_Homo sapiens_hsa043400.64807743
68Asthma_Homo sapiens_hsa053100.63555401
69Base excision repair_Homo sapiens_hsa034100.62561661
70p53 signaling pathway_Homo sapiens_hsa041150.60444149
71Allograft rejection_Homo sapiens_hsa053300.60091806
72Salivary secretion_Homo sapiens_hsa049700.59743791
73Histidine metabolism_Homo sapiens_hsa003400.59588398
74RNA transport_Homo sapiens_hsa030130.59556009
75Glutathione metabolism_Homo sapiens_hsa004800.58181196
76African trypanosomiasis_Homo sapiens_hsa051430.57606937
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56979036
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.56838863
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56721826
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52900586
81Purine metabolism_Homo sapiens_hsa002300.52770150
82Metabolic pathways_Homo sapiens_hsa011000.52495511
83Sulfur metabolism_Homo sapiens_hsa009200.52209144
84Huntingtons disease_Homo sapiens_hsa050160.51035945
85Arginine and proline metabolism_Homo sapiens_hsa003300.48955747
86Hematopoietic cell lineage_Homo sapiens_hsa046400.45871277
87PPAR signaling pathway_Homo sapiens_hsa033200.45841226
88Graft-versus-host disease_Homo sapiens_hsa053320.45064559
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42463203
90Type I diabetes mellitus_Homo sapiens_hsa049400.41967920
91Vitamin digestion and absorption_Homo sapiens_hsa049770.39541210
92Sphingolipid metabolism_Homo sapiens_hsa006000.38957299
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37569314
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35643355
95TGF-beta signaling pathway_Homo sapiens_hsa043500.34899190
96ABC transporters_Homo sapiens_hsa020100.34323578
97Arachidonic acid metabolism_Homo sapiens_hsa005900.34259029
98Spliceosome_Homo sapiens_hsa030400.34026930
99Hippo signaling pathway_Homo sapiens_hsa043900.33815993
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32120577

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