YWHAZ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)4.54831385
2keratinocyte development (GO:0003334)4.50946891
3synaptic vesicle exocytosis (GO:0016079)4.49548061
4vocalization behavior (GO:0071625)4.42504809
5protein localization to synapse (GO:0035418)4.24590207
6neuron cell-cell adhesion (GO:0007158)4.23505937
7regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.22697453
8glutamate secretion (GO:0014047)4.21184001
9DNA double-strand break processing (GO:0000729)4.11346402
10regulation of short-term neuronal synaptic plasticity (GO:0048172)4.09805730
11regulation of synaptic vesicle exocytosis (GO:2000300)4.09722627
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.08202491
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.03836286
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.98211603
15establishment of integrated proviral latency (GO:0075713)3.93624966
16negative regulation of dendrite development (GO:2000171)3.91132987
17negative regulation of dendrite morphogenesis (GO:0050774)3.87738945
18neurotransmitter-gated ion channel clustering (GO:0072578)3.81137949
19axonal fasciculation (GO:0007413)3.78861035
20synaptic vesicle maturation (GO:0016188)3.75620224
21neuronal action potential propagation (GO:0019227)3.74860189
22regulation of glutamate receptor signaling pathway (GO:1900449)3.74552823
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.73869573
24protein deneddylation (GO:0000338)3.73614247
25dendritic spine morphogenesis (GO:0060997)3.72630278
26nuclear pore complex assembly (GO:0051292)3.68062521
27regulation of long-term neuronal synaptic plasticity (GO:0048169)3.66758828
28regulation of synaptic vesicle transport (GO:1902803)3.61878135
29positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.48323049
30nuclear pore organization (GO:0006999)3.48175048
31regulation of neuronal synaptic plasticity (GO:0048168)3.45941996
32neuron-neuron synaptic transmission (GO:0007270)3.44321104
33neuron recognition (GO:0008038)3.41923706
34innervation (GO:0060384)3.37616431
35ribosome assembly (GO:0042255)3.35850880
36synaptic transmission, glutamatergic (GO:0035249)3.35341732
37long-term synaptic potentiation (GO:0060291)3.33875071
38postsynaptic membrane organization (GO:0001941)3.32512016
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.31182586
40adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.30922292
41auditory behavior (GO:0031223)3.28824346
42membrane budding (GO:0006900)3.28493701
43protein heterotetramerization (GO:0051290)3.28276959
44regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.25558232
45ionotropic glutamate receptor signaling pathway (GO:0035235)3.24888927
46presynaptic membrane assembly (GO:0097105)3.22651064
47serotonin receptor signaling pathway (GO:0007210)3.22590738
48non-recombinational repair (GO:0000726)3.22337421
49double-strand break repair via nonhomologous end joining (GO:0006303)3.22337421
50striatum development (GO:0021756)3.21066665
51peptidyl-cysteine modification (GO:0018198)3.20096260
52regulation of Rac protein signal transduction (GO:0035020)3.17647963
53regulation of synapse structural plasticity (GO:0051823)3.16092569
54establishment of viral latency (GO:0019043)3.13676833
55mitotic sister chromatid cohesion (GO:0007064)3.13392229
56Golgi transport vesicle coating (GO:0048200)3.11865768
57COPI coating of Golgi vesicle (GO:0048205)3.11865768
58neurotransmitter secretion (GO:0007269)3.11202761
59establishment of nucleus localization (GO:0040023)3.11018740
60positive regulation of synapse assembly (GO:0051965)3.10361436
61locomotory exploration behavior (GO:0035641)3.09838583
62regulation of centriole replication (GO:0046599)3.09538740
63regulation of cellular amino acid metabolic process (GO:0006521)3.08752223
64regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.06748623
65regulation of synaptic plasticity (GO:0048167)3.06456702
66retinal ganglion cell axon guidance (GO:0031290)3.06329948
67fatty acid elongation (GO:0030497)3.05281886
68mechanosensory behavior (GO:0007638)3.05163239
69behavioral fear response (GO:0001662)3.04670603
70behavioral defense response (GO:0002209)3.04670603
71regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.03632928
72synaptic vesicle endocytosis (GO:0048488)3.03181187
73pyrimidine nucleobase catabolic process (GO:0006208)3.03163948
74dendrite development (GO:0016358)3.03072721
75regulation of glutamate secretion (GO:0014048)3.02869503
76regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.02675610
77positive regulation of synapse maturation (GO:0090129)3.02285491
78ribonucleoprotein complex disassembly (GO:0032988)3.01477454
79regulation of excitatory postsynaptic membrane potential (GO:0060079)3.01125421
80cell migration in hindbrain (GO:0021535)2.98620504
81positive regulation of protein autophosphorylation (GO:0031954)2.98340918
82histone H2A acetylation (GO:0043968)2.96978361
83response to auditory stimulus (GO:0010996)2.96150208
84positive regulation of glycoprotein metabolic process (GO:1903020)2.96090925
85exploration behavior (GO:0035640)2.94986648
86positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.94785696
87negative regulation of synaptic transmission, GABAergic (GO:0032229)2.94034506
88presynaptic membrane organization (GO:0097090)2.94021252
89establishment of chromosome localization (GO:0051303)2.93823516
90glutamate receptor signaling pathway (GO:0007215)2.93564036
91regulation of postsynaptic membrane potential (GO:0060078)2.93248538
92regulation of NFAT protein import into nucleus (GO:0051532)2.91995745
93dendritic spine organization (GO:0097061)2.91140886
94negative regulation of microtubule polymerization (GO:0031115)2.90753927
95negative regulation of axon guidance (GO:1902668)2.90390472
96cerebellar granule cell differentiation (GO:0021707)2.89579016
97negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.88267866
98regulation of synapse assembly (GO:0051963)2.87675142
99L-serine transport (GO:0015825)2.86572260
100hepatocyte apoptotic process (GO:0097284)2.86458756
101synapse assembly (GO:0007416)2.86457798
102startle response (GO:0001964)2.85997515
103DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.85663996
104intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.84667072
105signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.84667072
106anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.84420594
107central nervous system projection neuron axonogenesis (GO:0021952)2.83826884
108glial cell proliferation (GO:0014009)2.82102075
109signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.81560914
110signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.81560914
111signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.81560914
112DNA damage response, detection of DNA damage (GO:0042769)2.80771934
113learning (GO:0007612)2.79916948
114signal transduction involved in cell cycle checkpoint (GO:0072395)2.78922299
115positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.76345290
116pore complex assembly (GO:0046931)2.76183530
117positive regulation of membrane potential (GO:0045838)2.75726424
118de novo protein folding (GO:0006458)2.71862209
119positive regulation of mitochondrial fission (GO:0090141)2.71449571
120signal transduction involved in DNA integrity checkpoint (GO:0072401)2.70978703
121signal transduction involved in DNA damage checkpoint (GO:0072422)2.70978703
122fear response (GO:0042596)2.70499589
123G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.66951945
124transferrin transport (GO:0033572)2.66565585
125regulation of cofactor metabolic process (GO:0051193)2.65728668
126regulation of coenzyme metabolic process (GO:0051196)2.65728668
127UDP-N-acetylglucosamine metabolic process (GO:0006047)2.65527924
128regulation of neurotransmitter secretion (GO:0046928)2.65060898
129regulation of synapse organization (GO:0050807)2.63737279
130negative regulation of keratinocyte proliferation (GO:0010839)2.63452624
131de novo posttranslational protein folding (GO:0051084)2.62998823
132negative regulation of DNA recombination (GO:0045910)2.62763149
133regulation of synaptic transmission, glutamatergic (GO:0051966)2.62513170
134negative regulation of amino acid transport (GO:0051956)2.62343785
135metaphase plate congression (GO:0051310)2.61987110
136neuron projection extension involved in neuron projection guidance (GO:1902284)2.61881481
137axon extension involved in axon guidance (GO:0048846)2.61881481
138cerebellar Purkinje cell differentiation (GO:0021702)2.60854442
139RNA-dependent DNA replication (GO:0006278)2.60330173
140mitotic metaphase plate congression (GO:0007080)2.59785052
141positive regulation of actin filament depolymerization (GO:0030836)2.59598313
142cullin deneddylation (GO:0010388)2.59223147
143Rap protein signal transduction (GO:0032486)2.58938107
144lactate metabolic process (GO:0006089)2.58322546
145positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.57865971
146dopamine receptor signaling pathway (GO:0007212)2.57776203
147negative regulation of ligase activity (GO:0051352)2.57618682
148negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.57618682
149positive regulation of synaptic transmission, GABAergic (GO:0032230)2.57479052
150regulation of transforming growth factor beta2 production (GO:0032909)2.56837269
151response to X-ray (GO:0010165)2.56834306
152regulation of respiratory system process (GO:0044065)2.56280922
153regulation of dendritic spine morphogenesis (GO:0061001)2.56122144
154positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.55541606
155inositol phosphate catabolic process (GO:0071545)2.55355144
156intestinal epithelial cell development (GO:0060576)2.54976855
157regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.54764387
158cerebellum development (GO:0021549)2.53490776
159synaptic vesicle transport (GO:0048489)2.53388442
160establishment of synaptic vesicle localization (GO:0097480)2.53388442
161organelle disassembly (GO:1903008)2.52850439
162chaperone-mediated protein transport (GO:0072321)2.51972026
163regulation of synapse maturation (GO:0090128)2.51665474
164protein K11-linked ubiquitination (GO:0070979)2.51021491
165response to amphetamine (GO:0001975)2.50605023
166desmosome organization (GO:0002934)2.49922657
167positive regulation of synaptic transmission (GO:0050806)2.49530859
168hippocampus development (GO:0021766)2.48928040
169somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.48008551
170somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.48008551
171isotype switching (GO:0045190)2.48008551
172regulation of sulfur metabolic process (GO:0042762)2.47663788
173spindle checkpoint (GO:0031577)2.46554325
174positive regulation of ligase activity (GO:0051351)2.45737026
175regulation of sister chromatid cohesion (GO:0007063)2.43813234
176DNA ligation (GO:0006266)2.43082659
177mitotic spindle organization (GO:0007052)2.41690260
178tRNA aminoacylation for protein translation (GO:0006418)2.39853736
179positive regulation of glycoprotein biosynthetic process (GO:0010560)2.39591548
180deoxyribonucleotide biosynthetic process (GO:0009263)2.39454796
181regulation of ubiquitin-protein transferase activity (GO:0051438)2.38325369
182sister chromatid segregation (GO:0000819)2.37345624
183CENP-A containing nucleosome assembly (GO:0034080)2.35491748
184regulation of helicase activity (GO:0051095)2.33486418
185amino acid activation (GO:0043038)2.33420325
186tRNA aminoacylation (GO:0043039)2.33420325
187cholesterol biosynthetic process (GO:0006695)2.32719389
188ER overload response (GO:0006983)2.32692880
189protein localization to kinetochore (GO:0034501)2.32602766
190mitotic spindle checkpoint (GO:0071174)2.32263946
191regulation of acyl-CoA biosynthetic process (GO:0050812)2.32261049
192regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.30528761
193neural tube formation (GO:0001841)2.29743077
194regulation of ligase activity (GO:0051340)2.28923211
195negative regulation of axon extension involved in axon guidance (GO:0048843)2.26790510
196mitotic sister chromatid segregation (GO:0000070)2.26474403
197DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.25702204
198regulation of clathrin-mediated endocytosis (GO:2000369)2.24923277

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.66316526
2GBX2_23144817_ChIP-Seq_PC3_Human4.34984669
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.65079030
4E2F7_22180533_ChIP-Seq_HELA_Human2.86286778
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.85533734
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.80151790
7TAF15_26573619_Chip-Seq_HEK293_Human2.75852643
8* ELK1_19687146_ChIP-ChIP_HELA_Human2.69126162
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.67193462
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.67065926
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.57197355
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.57033744
13PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.55332780
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.53976132
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.46038035
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.44502389
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.39607005
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.37437079
19AR_21909140_ChIP-Seq_LNCAP_Human2.31725439
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.29388420
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.28526020
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.27997561
23RNF2_18974828_ChIP-Seq_MESCs_Mouse2.27997561
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.26854868
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24972571
26REST_21632747_ChIP-Seq_MESCs_Mouse2.22218673
27CTBP2_25329375_ChIP-Seq_LNCAP_Human2.20429499
28JARID2_20075857_ChIP-Seq_MESCs_Mouse2.17914808
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.17020260
30PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.16494398
31PADI4_21655091_ChIP-ChIP_MCF-7_Human2.13308500
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.11509521
33RNF2_27304074_Chip-Seq_ESCs_Mouse2.09850550
34* P300_19829295_ChIP-Seq_ESCs_Human2.07657001
35FOXM1_23109430_ChIP-Seq_U2OS_Human2.05898749
36IGF1R_20145208_ChIP-Seq_DFB_Human2.05200828
37* RARB_27405468_Chip-Seq_BRAIN_Mouse2.01519723
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.94092399
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93317512
40FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.90810559
41WT1_19549856_ChIP-ChIP_CCG9911_Human1.88054836
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.86396848
43SMAD4_21799915_ChIP-Seq_A2780_Human1.83208454
44TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.81986159
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.80153319
46SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.79940882
47RNF2_27304074_Chip-Seq_NSC_Mouse1.79855456
48MTF2_20144788_ChIP-Seq_MESCs_Mouse1.79254358
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78816009
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77265392
51SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76559180
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74860385
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74292134
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.72506676
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.69410945
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.68319017
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.67132636
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.67119745
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.65713663
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65437886
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.64580837
62EST1_17652178_ChIP-ChIP_JURKAT_Human1.63380594
63NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.63128641
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.62140064
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56012507
66MYCN_18555785_ChIP-Seq_MESCs_Mouse1.55861502
67NELFA_20434984_ChIP-Seq_ESCs_Mouse1.55699911
68FUS_26573619_Chip-Seq_HEK293_Human1.49795245
69* EWS_26573619_Chip-Seq_HEK293_Human1.48428548
70AR_21572438_ChIP-Seq_LNCaP_Human1.46498887
71CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.44780989
72AR_25329375_ChIP-Seq_VCAP_Human1.44600924
73DCP1A_22483619_ChIP-Seq_HELA_Human1.43452745
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41759469
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41627935
76DROSHA_22980978_ChIP-Seq_HELA_Human1.41126035
77* SMAD3_21741376_ChIP-Seq_EPCs_Human1.40712335
78JUN_21703547_ChIP-Seq_K562_Human1.38350255
79* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37411590
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35502324
81ZNF274_21170338_ChIP-Seq_K562_Hela1.35206661
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34034317
83* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32263748
84RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.32008461
85FOXM1_26456572_ChIP-Seq_MCF-7_Human1.30941034
86IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30819905
87SOX9_26525672_Chip-Seq_HEART_Mouse1.30579314
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.29145899
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.28171263
90FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.27979207
91BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27421280
92YAP1_20516196_ChIP-Seq_MESCs_Mouse1.27004443
93* STAT3_23295773_ChIP-Seq_U87_Human1.26184850
94SOX2_21211035_ChIP-Seq_LN229_Gbm1.25823892
95VDR_23849224_ChIP-Seq_CD4+_Human1.24685689
96SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.24149311
97YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23601927
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22424674
99RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18229677
100* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17793890
101P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17202387
102CMYC_18555785_Chip-Seq_ESCs_Mouse1.16781880
103AHR_22903824_ChIP-Seq_MCF-7_Human1.16759756
104* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16045263
105ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15845259
106TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15767543
107EZH2_27294783_Chip-Seq_NPCs_Mouse1.15257721
108* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14606784
109SMAD_19615063_ChIP-ChIP_OVARY_Human1.14419046
110GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14142632
111PRDM14_20953172_ChIP-Seq_ESCs_Human1.13925854
112HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13746323
113HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13656664
114SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12627580
115* RUNX2_22187159_ChIP-Seq_PCA_Human1.11913430
116FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.11745866
117MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10929556
118AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10541499
119* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.10383450
120* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.10383450
121AR_19668381_ChIP-Seq_PC3_Human1.08063247
122P300_18555785_Chip-Seq_ESCs_Mouse1.07768428
123VDR_22108803_ChIP-Seq_LS180_Human1.06258961
124* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.05869544
125* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05865944
126* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05865944
127NFE2_27457419_Chip-Seq_LIVER_Mouse1.05460279
128NANOG_18555785_Chip-Seq_ESCs_Mouse1.04935460
129MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.04564117
130EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04562413
131* BRD4_25478319_ChIP-Seq_HGPS_Human1.03886432
132TCF4_23295773_ChIP-Seq_U87_Human1.03458252
133CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02591766
134* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01960537
135E2F1_21310950_ChIP-Seq_MCF-7_Human1.01079263
136RING1B_27294783_Chip-Seq_NPCs_Mouse1.00259222
137ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99987086
138FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.99962569
139RING1B_27294783_Chip-Seq_ESCs_Mouse0.99885905
140E2F1_18555785_Chip-Seq_ESCs_Mouse0.99467419
141* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98328723
142* SOX17_20123909_ChIP-Seq_XEN_Mouse0.98250340
143CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98238651
144* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97635578
145HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97615237
146* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96327236
147NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96269776
148NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.96123285
149NANOG_16153702_ChIP-ChIP_HESCs_Human0.95830490
150ER_23166858_ChIP-Seq_MCF-7_Human0.95824615
151ELF5_23300383_ChIP-Seq_T47D_Human0.95813464
152SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95724591
153TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95300170
154POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95300170
155* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95054657
156POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94993803
157SOX2_18555785_Chip-Seq_ESCs_Mouse0.94963704
158TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94925623
159TP53_18474530_ChIP-ChIP_U2OS_Human0.94828883
160* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94713339
161NMYC_18555785_Chip-Seq_ESCs_Mouse0.94094009
162OCT4_18555785_Chip-Seq_ESCs_Mouse0.94043584
163E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.94041593
164P53_22387025_ChIP-Seq_ESCs_Mouse0.93709845
165* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93202039
166GABP_19822575_ChIP-Seq_HepG2_Human0.92897113
167SALL1_21062744_ChIP-ChIP_HESCs_Human0.92239018

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.88119670
2MP0004859_abnormal_synaptic_plasticity4.81139143
3MP0010234_abnormal_vibrissa_follicle3.56952529
4MP0003635_abnormal_synaptic_transmissio3.29573404
5MP0003122_maternal_imprinting3.29149172
6MP0001529_abnormal_vocalization3.02139631
7MP0002063_abnormal_learning/memory/cond3.01314955
8MP0004270_analgesia2.99973917
9MP0001968_abnormal_touch/_nociception2.83161851
10MP0006054_spinal_hemorrhage2.62419462
11MP0009745_abnormal_behavioral_response2.58804574
12MP0006276_abnormal_autonomic_nervous2.56690282
13MP0004957_abnormal_blastocyst_morpholog2.48108116
14MP0002735_abnormal_chemical_nociception2.44198238
15MP0000778_abnormal_nervous_system2.38001765
16MP0002572_abnormal_emotion/affect_behav2.31557973
17MP0002064_seizures2.28319466
18MP0002736_abnormal_nociception_after2.27242287
19MP0010678_abnormal_skin_adnexa2.27076102
20MP0003787_abnormal_imprinting2.24867292
21MP0005248_abnormal_Harderian_gland2.23873040
22MP0003121_genomic_imprinting2.10821269
23MP0010094_abnormal_chromosome_stability2.10785786
24MP0002877_abnormal_melanocyte_morpholog2.06405390
25MP0003693_abnormal_embryo_hatching2.04966159
26MP0002734_abnormal_mechanical_nocicepti2.04016174
27MP0002184_abnormal_innervation2.00047069
28MP0003221_abnormal_cardiomyocyte_apopto1.94075528
29MP0000647_abnormal_sebaceous_gland1.93765603
30MP0008932_abnormal_embryonic_tissue1.92473244
31MP0010352_gastrointestinal_tract_polyps1.91743837
32MP0000372_irregular_coat_pigmentation1.90655338
33MP0001984_abnormal_olfaction1.89958017
34MP0009046_muscle_twitch1.88806234
35MP0002822_catalepsy1.84835255
36MP0000569_abnormal_digit_pigmentation1.84012299
37MP0001188_hyperpigmentation1.80497039
38MP0003941_abnormal_skin_development1.78882631
39MP0002272_abnormal_nervous_system1.77589693
40MP0005646_abnormal_pituitary_gland1.75428050
41MP0008058_abnormal_DNA_repair1.72277969
42MP0001486_abnormal_startle_reflex1.69681570
43MP0002557_abnormal_social/conspecific_i1.69358993
44MP0000427_abnormal_hair_cycle1.67174036
45MP0004811_abnormal_neuron_physiology1.66729139
46MP0005423_abnormal_somatic_nervous1.66708608
47MP0002067_abnormal_sensory_capabilities1.64831851
48MP0008057_abnormal_DNA_replication1.60095529
49MP0001440_abnormal_grooming_behavior1.56422250
50MP0004924_abnormal_behavior1.54080715
51MP0005386_behavior/neurological_phenoty1.54080715
52MP0000383_abnormal_hair_follicle1.53933090
53MP0002733_abnormal_thermal_nociception1.53625580
54MP0003077_abnormal_cell_cycle1.52922271
55MP0002751_abnormal_autonomic_nervous1.52612473
56MP0003111_abnormal_nucleus_morphology1.51173778
57MP0002796_impaired_skin_barrier1.49451272
58MP0004264_abnormal_extraembryonic_tissu1.49323478
59MP0002090_abnormal_vision1.45700097
60MP0001970_abnormal_pain_threshold1.44414950
61MP0002653_abnormal_ependyma_morphology1.42824778
62MP0004782_abnormal_surfactant_physiolog1.41261551
63MP0010030_abnormal_orbit_morphology1.39867637
64MP0003123_paternal_imprinting1.39324547
65MP0004484_altered_response_of1.37072614
66MP0005408_hypopigmentation1.36973225
67MP0000516_abnormal_urinary_system1.36139439
68MP0005367_renal/urinary_system_phenotyp1.36139439
69MP0008007_abnormal_cellular_replicative1.34254054
70MP0005645_abnormal_hypothalamus_physiol1.32666501
71MP0000955_abnormal_spinal_cord1.32450761
72MP0001905_abnormal_dopamine_level1.29543753
73MP0003937_abnormal_limbs/digits/tail_de1.28638958
74MP0001697_abnormal_embryo_size1.27135785
75MP0001501_abnormal_sleep_pattern1.26424008
76MP0005501_abnormal_skin_physiology1.24677911
77MP0002084_abnormal_developmental_patter1.24393387
78MP0001730_embryonic_growth_arrest1.24006269
79MP0002882_abnormal_neuron_morphology1.23565071
80MP0005623_abnormal_meninges_morphology1.22860953
81MP0008569_lethality_at_weaning1.21441658
82MP0004197_abnormal_fetal_growth/weight/1.20798569
83MP0000537_abnormal_urethra_morphology1.18558394
84MP0003315_abnormal_perineum_morphology1.17344641
85MP0010386_abnormal_urinary_bladder1.16024053
86MP0005075_abnormal_melanosome_morpholog1.15581098
87MP0000579_abnormal_nail_morphology1.15504391
88MP0002102_abnormal_ear_morphology1.15454731
89MP0003890_abnormal_embryonic-extraembry1.15443496
90MP0005187_abnormal_penis_morphology1.14788842
91MP0009780_abnormal_chondrocyte_physiolo1.14280744
92MP0002233_abnormal_nose_morphology1.13761295
93MP0005499_abnormal_olfactory_system1.13558225
94MP0005394_taste/olfaction_phenotype1.13558225
95MP0005380_embryogenesis_phenotype1.13517578
96MP0001672_abnormal_embryogenesis/_devel1.13517578
97MP0003786_premature_aging1.12563166
98MP0001293_anophthalmia1.11553973
99MP0003943_abnormal_hepatobiliary_system1.09585948
100MP0008877_abnormal_DNA_methylation1.09370326
101MP0000350_abnormal_cell_proliferation1.08728373
102MP0002152_abnormal_brain_morphology1.08326678
103MP0000566_synostosis1.07874333
104MP0000631_abnormal_neuroendocrine_gland1.06959090
105MP0004858_abnormal_nervous_system1.06417576
106MP0000377_abnormal_hair_follicle1.05876267
107MP0009672_abnormal_birth_weight1.04276294
108MP0000358_abnormal_cell_content/1.03240125
109MP0002066_abnormal_motor_capabilities/c1.01090769
110MP0001216_abnormal_epidermal_layer1.00460427
111MP0002085_abnormal_embryonic_tissue1.00159600
112MP0003879_abnormal_hair_cell0.99413545
113MP0009703_decreased_birth_body0.99096388
114MP0001286_abnormal_eye_development0.99064030
115MP0004133_heterotaxia0.99025543
116MP0004742_abnormal_vestibular_system0.98613510
117MP0003861_abnormal_nervous_system0.96446197
118MP0002177_abnormal_outer_ear0.96064903
119MP0000534_abnormal_ureter_morphology0.95665640
120MP0003566_abnormal_cell_adhesion0.95455793
121MP0003942_abnormal_urinary_system0.94830910
122MP0003183_abnormal_peptide_metabolism0.93129697
123MP0002088_abnormal_embryonic_growth/wei0.92729413
124MP0002080_prenatal_lethality0.92315699
125MP0003984_embryonic_growth_retardation0.92310804
126MP0008260_abnormal_autophagy0.90326844
127MP0003718_maternal_effect0.89369914
128MP0002876_abnormal_thyroid_physiology0.87921515
129MP0008961_abnormal_basal_metabolism0.87730270
130MP0002086_abnormal_extraembryonic_tissu0.86722486
131MP0001502_abnormal_circadian_rhythm0.85117449
132MP0002638_abnormal_pupillary_reflex0.84325860
133MP0001986_abnormal_taste_sensitivity0.84229634
134MP0005384_cellular_phenotype0.84060117
135MP0008789_abnormal_olfactory_epithelium0.82941968
136MP0002909_abnormal_adrenal_gland0.82591985
137MP0002098_abnormal_vibrissa_morphology0.82517012
138MP0001299_abnormal_eye_distance/0.81076758
139MP0001191_abnormal_skin_condition0.80533222
140MP0003567_abnormal_fetal_cardiomyocyte0.79920416
141MP0010771_integument_phenotype0.77465855
142MP0000026_abnormal_inner_ear0.77449658
143MP0004272_abnormal_basement_membrane0.76698338
144MP0009697_abnormal_copulation0.76482927
145MP0005197_abnormal_uvea_morphology0.75593557
146MP0002069_abnormal_eating/drinking_beha0.75099825
147MP0002282_abnormal_trachea_morphology0.74693266
148MP0001943_abnormal_respiration0.70357933
149MP0001177_atelectasis0.70153517
150MP0004142_abnormal_muscle_tone0.70018163
151MP0005171_absent_coat_pigmentation0.68591488
152MP0002752_abnormal_somatic_nervous0.68475521
153MP0002160_abnormal_reproductive_system0.67486768
154MP0001963_abnormal_hearing_physiology0.67400277
155MP0002081_perinatal_lethality0.66793586
156MP0004085_abnormal_heartbeat0.66224039
157MP0000015_abnormal_ear_pigmentation0.61557559
158MP0003119_abnormal_digestive_system0.59431210
159MP0002234_abnormal_pharynx_morphology0.59068415
160MP0010770_preweaning_lethality0.58997966
161MP0002082_postnatal_lethality0.58997966
162MP0003385_abnormal_body_wall0.58934782
163MP0003755_abnormal_palate_morphology0.57586880
164MP0008872_abnormal_physiological_respon0.57272198
165MP0006292_abnormal_olfactory_placode0.56974499
166MP0003137_abnormal_impulse_conducting0.56947871
167MP0002938_white_spotting0.55593310
168MP0000049_abnormal_middle_ear0.54692852

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.81256798
2Epileptic encephalopathy (HP:0200134)4.28233774
3Myokymia (HP:0002411)4.28196260
4Focal seizures (HP:0007359)4.00708881
5Abnormal hair whorl (HP:0010721)3.79603762
6Hyperventilation (HP:0002883)3.59332325
7Febrile seizures (HP:0002373)3.40782839
8Progressive cerebellar ataxia (HP:0002073)3.35670261
9Cortical dysplasia (HP:0002539)3.24082787
10Abnormality of the labia minora (HP:0012880)3.21771396
11Insidious onset (HP:0003587)3.19956357
12Termporal pattern (HP:0011008)3.19956357
13Atonic seizures (HP:0010819)3.13684462
14Broad-based gait (HP:0002136)3.07851076
15Volvulus (HP:0002580)3.00997269
16Absence seizures (HP:0002121)2.86024898
17Amblyopia (HP:0000646)2.81982288
18Failure to thrive in infancy (HP:0001531)2.75238005
19Heterochromia iridis (HP:0001100)2.73580268
20Upper limb muscle weakness (HP:0003484)2.73432185
21Protruding tongue (HP:0010808)2.68128919
22Visual hallucinations (HP:0002367)2.67120760
23Ependymoma (HP:0002888)2.65290072
24Gait imbalance (HP:0002141)2.64847166
25Abnormal auditory evoked potentials (HP:0006958)2.62872557
26Absent eyebrow (HP:0002223)2.61289746
27Breast carcinoma (HP:0003002)2.58515202
28Congenital primary aphakia (HP:0007707)2.49252396
29Dialeptic seizures (HP:0011146)2.47598618
30Amyotrophic lateral sclerosis (HP:0007354)2.44807710
31Transitional cell carcinoma of the bladder (HP:0006740)2.43054386
32Nephrogenic diabetes insipidus (HP:0009806)2.42126106
33Papilledema (HP:0001085)2.38965047
34Hypothermia (HP:0002045)2.38257033
35Astrocytoma (HP:0009592)2.37380479
36Abnormality of the astrocytes (HP:0100707)2.37380479
37Freckling (HP:0001480)2.37211698
38Cutaneous melanoma (HP:0012056)2.36406727
39Medulloblastoma (HP:0002885)2.35058401
40Drooling (HP:0002307)2.34673098
41Excessive salivation (HP:0003781)2.34673098
42Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.34116322
43Truncal ataxia (HP:0002078)2.31556948
44Abnormal lung lobation (HP:0002101)2.30926367
45Medial flaring of the eyebrow (HP:0010747)2.28533822
46Poor eye contact (HP:0000817)2.26661695
47Abnormality of glycolysis (HP:0004366)2.26328299
48Specific learning disability (HP:0001328)2.26121735
49Growth hormone deficiency (HP:0000824)2.25481207
50Postnatal microcephaly (HP:0005484)2.25445495
51Bladder neoplasm (HP:0009725)2.24886551
52Bladder carcinoma (HP:0002862)2.24886551
53Polyphagia (HP:0002591)2.23913283
54Limb dystonia (HP:0002451)2.22741798
55Abnormal eating behavior (HP:0100738)2.17605364
56Exotropia (HP:0000577)2.17418401
57Degeneration of anterior horn cells (HP:0002398)2.17089872
58Abnormality of the anterior horn cell (HP:0006802)2.17089872
59Sleep apnea (HP:0010535)2.16806429
60Abnormality of chromosome stability (HP:0003220)2.16226688
61Glioma (HP:0009733)2.15834579
62Shoulder girdle muscle weakness (HP:0003547)2.15403158
63Adrenal hypoplasia (HP:0000835)2.15318998
64Generalized tonic-clonic seizures (HP:0002069)2.14286577
65Rhabdomyosarcoma (HP:0002859)2.12854660
66Narrow nasal bridge (HP:0000446)2.12315382
67Lissencephaly (HP:0001339)2.10925273
68Genetic anticipation (HP:0003743)2.10869558
69Biliary tract neoplasm (HP:0100574)2.09684562
70Fair hair (HP:0002286)2.09452545
71Bifid tongue (HP:0010297)2.08474953
72Spinal canal stenosis (HP:0003416)2.08402728
73Pheochromocytoma (HP:0002666)2.05404932
74Aqueductal stenosis (HP:0002410)2.05148448
75Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.05122493
76Absent speech (HP:0001344)2.04994452
77Uterine neoplasm (HP:0010784)2.04647889
78Gaze-evoked nystagmus (HP:0000640)2.00671011
79Stereotypic behavior (HP:0000733)2.00377569
80Tetraparesis (HP:0002273)1.99868789
81Epileptiform EEG discharges (HP:0011182)1.99668427
82Microglossia (HP:0000171)1.98726363
83Leiomyosarcoma (HP:0100243)1.97698196
84Uterine leiomyosarcoma (HP:0002891)1.97698196
85Fetal akinesia sequence (HP:0001989)1.97542482
86Deviation of the thumb (HP:0009603)1.96765782
87Abnormality of the preputium (HP:0100587)1.94135428
88Gastrointestinal carcinoma (HP:0002672)1.93880914
89Malignant gastrointestinal tract tumors (HP:0006749)1.93880914
90Ankyloglossia (HP:0010296)1.93329275
91Abnormality of the corticospinal tract (HP:0002492)1.93081382
92Ovarian neoplasm (HP:0100615)1.91579576
93Pointed chin (HP:0000307)1.91138097
94Genital tract atresia (HP:0001827)1.91112879
95Hip dysplasia (HP:0001385)1.89903549
96Impaired vibration sensation in the lower limbs (HP:0002166)1.89559039
97Proximal placement of thumb (HP:0009623)1.89289543
98Poor coordination (HP:0002370)1.88517235
99Vaginal atresia (HP:0000148)1.88427316
100Atrophy/Degeneration involving motor neurons (HP:0007373)1.88393274
101Increased serum pyruvate (HP:0003542)1.88200040
102Autoamputation (HP:0001218)1.87919916
103Generalized hypopigmentation of hair (HP:0011358)1.86832978
104True hermaphroditism (HP:0010459)1.85935750
105Thyroid carcinoma (HP:0002890)1.85788366
106Neuroendocrine neoplasm (HP:0100634)1.85530249
107Meckel diverticulum (HP:0002245)1.85107463
108Abnormal pancreas size (HP:0012094)1.84379394
109Neoplasm of the adrenal cortex (HP:0100641)1.84136505
110Blue irides (HP:0000635)1.83961093
111Delusions (HP:0000746)1.83547784
112Papillary thyroid carcinoma (HP:0002895)1.83324018
113Hypoventilation (HP:0002791)1.82997247
114Inability to walk (HP:0002540)1.82845015
115Annular pancreas (HP:0001734)1.79716919
116Tongue fasciculations (HP:0001308)1.78940756
117Nephroblastoma (Wilms tumor) (HP:0002667)1.78602483
118Embryonal renal neoplasm (HP:0011794)1.78336585
119Hypoplastic pelvis (HP:0008839)1.77780375
120Abnormality of the ileum (HP:0001549)1.77364358
121Cholecystitis (HP:0001082)1.76117923
122Abnormal gallbladder physiology (HP:0012438)1.76117923
123Hypoplastic labia majora (HP:0000059)1.75826936
124Palpebral edema (HP:0100540)1.75167337
125Abnormality of the aortic arch (HP:0012303)1.75019473
126Abnormality of salivation (HP:0100755)1.74947496
127EEG with generalized epileptiform discharges (HP:0011198)1.74525364
128Abnormal umbilical cord blood vessels (HP:0011403)1.74029519
129Single umbilical artery (HP:0001195)1.74029519
130Abnormality of the fetal cardiovascular system (HP:0010948)1.74029519
131Intestinal atresia (HP:0011100)1.73143486
132Small intestinal stenosis (HP:0012848)1.73098727
133Duodenal stenosis (HP:0100867)1.73098727
134Aplasia/Hypoplasia of the lens (HP:0008063)1.72708936
135Scanning speech (HP:0002168)1.72576050
136Poor suck (HP:0002033)1.72051267
137Sparse eyelashes (HP:0000653)1.72008303
138Abnormal social behavior (HP:0012433)1.71572246
139Impaired social interactions (HP:0000735)1.71572246
140Hypoplasia of the brainstem (HP:0002365)1.71232519
141Aplasia/Hypoplasia of the brainstem (HP:0007362)1.71232519
142Progressive inability to walk (HP:0002505)1.70775391
143Esotropia (HP:0000565)1.70665074
144Depression (HP:0000716)1.70104008
145Neoplasm of the thyroid gland (HP:0100031)1.69924824
146Incomplete penetrance (HP:0003829)1.68787786
147Labial hypoplasia (HP:0000066)1.68330295
148Neoplasm of the peripheral nervous system (HP:0100007)1.68233753
149Muscular hypotonia of the trunk (HP:0008936)1.68129418
150Micronodular cirrhosis (HP:0001413)1.67990258
151Renal hypoplasia (HP:0000089)1.67483617
152Action tremor (HP:0002345)1.66789539
153Cerebral hypomyelination (HP:0006808)1.66189453
154Tented upper lip vermilion (HP:0010804)1.65627353
155Myelomeningocele (HP:0002475)1.65494158
156Hyperthyroidism (HP:0000836)1.65413305
157Abnormality of the hip-girdle musculature (HP:0001445)1.64967294
158Abnormality of the musculature of the pelvis (HP:0001469)1.64967294
159Aplasia/Hypoplasia of the uvula (HP:0010293)1.64646956
160Spastic diplegia (HP:0001264)1.64427800
161Blepharitis (HP:0000498)1.64255302
162Aplasia/hypoplasia of the humerus (HP:0006507)1.63484202
163Abnormality of the lower motor neuron (HP:0002366)1.63331899
164Urinary urgency (HP:0000012)1.62797681
165Impaired smooth pursuit (HP:0007772)1.62764809
166Hypsarrhythmia (HP:0002521)1.62748224
167Hepatoblastoma (HP:0002884)1.62731131
168Chromosomal breakage induced by crosslinking agents (HP:0003221)1.62723037
169Short foot (HP:0001773)1.62066701
170Onycholysis (HP:0001806)1.61701512
171Agnosia (HP:0010524)1.61470279
172Ankle clonus (HP:0011448)1.61298299
173Chorioretinal coloboma (HP:0000567)1.60269048
174Chromsome breakage (HP:0040012)1.59306582
175Deep palmar crease (HP:0006191)1.59284309
176Degeneration of the lateral corticospinal tracts (HP:0002314)1.59095173
177Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.59095173
178Abnormality of incisor morphology (HP:0011063)1.57053631
179Neoplasm of the adrenal gland (HP:0100631)1.56271181
180Hypoplastic female external genitalia (HP:0012815)1.55736412
181Curly hair (HP:0002212)1.54972178

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.38892877
2MAP3K124.22473348
3MST43.68967034
4NTRK33.64247034
5EPHA42.83616306
6PLK22.79350086
7SRPK12.68694747
8MAP2K72.64590352
9MARK12.63023406
10PRPF4B2.60720840
11* BCR2.53928542
12* MINK12.53769628
13MAP3K42.49978594
14MAP3K92.49423814
15NTRK22.48257301
16ERBB32.41603823
17DAPK12.23987598
18* KSR12.12899124
19MKNK22.04400675
20PBK2.04232317
21MST1R1.99398763
22EPHB21.94427693
23BUB11.83917232
24CCNB11.75895536
25WEE11.75043817
26CDK191.74029308
27SGK21.74026256
28MAPK131.63086857
29EPHA21.52416144
30UHMK11.46888868
31NTRK11.45543723
32AKT31.44851583
33PAK41.41900791
34MAP4K21.40756031
35DAPK21.39046374
36BRSK21.38943438
37SGK2231.38216684
38SGK4941.38216684
39TSSK61.33790793
40ERBB41.33633455
41CSNK1A1L1.31226214
42FGFR21.30965851
43PLK31.27221244
44BMPR21.26986608
45CSNK1G31.26073400
46ARAF1.25656424
47MAP2K41.24129805
48BMPR1B1.23473702
49STK391.22978516
50SCYL21.20113451
51CDK51.19697478
52MET1.17953964
53RIPK41.17720261
54MAP3K31.16013761
55TTK1.14018854
56RPS6KA41.13389212
57EIF2AK21.13108700
58CDK141.12464742
59CSNK1G11.10926108
60LATS11.09900784
61PLK41.08140469
62STK38L1.07890302
63LIMK11.04478752
64PRKCG1.03814159
65STK31.01565321
66EIF2AK31.00119964
67TAOK20.98640650
68CDK150.98605030
69* CDK180.98605030
70STK100.96004100
71PAK60.94805522
72SGK30.93333637
73BRAF0.88726620
74SIK20.86798551
75NUAK10.86421682
76CAMKK10.86113227
77CDK11A0.84156014
78CDK80.83414818
79BRSK10.82686105
80KSR20.80351909
81DYRK20.79920355
82CAMKK20.79665602
83FER0.78453596
84GRK50.77949244
85CAMK2A0.77609229
86DYRK1A0.74041402
87PLK10.73782447
88CDK60.73750570
89NEK10.72725065
90TNIK0.67668066
91PTK2B0.67554768
92TAF10.65927500
93PRKCE0.64184425
94TESK10.63416827
95TGFBR10.61292004
96WNK30.60922917
97LMTK20.60545065
98VRK10.60514967
99PNCK0.60084086
100NEK60.59267322
101YES10.58994420
102CAMK2B0.58845360
103RAF10.56561558
104SGK10.56506360
105TYRO30.56347041
106BRD40.55485392
107FGFR10.54696955
108ACVR1B0.51985386
109EGFR0.51578925
110STK240.50266543
111PRKCI0.48846519
112RPS6KA20.47488371
113PKN20.47084623
114PTK20.46482884
115PIK3CA0.45772181
116FGFR30.44131223
117DYRK30.43485648
118CAMK2D0.43208428
119MAP2K10.41605911
120PRKCZ0.41541478
121ADRBK10.41485631
122PAK30.40076488
123RPS6KB10.39904797
124PRKD30.39361609
125OXSR10.39159634
126ROCK20.38616905
127ATM0.36893251
128ERBB20.36317265
129EIF2AK10.34163071
130CSNK1D0.33221282
131ALK0.31886344
132NME10.31691642
133CLK10.29861010
134MKNK10.29836360
135ATR0.29530017
136STK380.29333898
137FRK0.29305655
138MAPK100.28889578
139ROCK10.28776792
140MYLK0.27887652
141CSNK1G20.25303675
142CAMK40.25227391
143IRAK20.25090322
144ADRBK20.24527104
145FYN0.24302902
146LATS20.24210947
147CAMK10.23306253
148MAP3K50.22895397

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.50675164
2Nicotine addiction_Homo sapiens_hsa050333.17439943
3Synaptic vesicle cycle_Homo sapiens_hsa047213.02272418
4Non-homologous end-joining_Homo sapiens_hsa034502.96886243
5Steroid biosynthesis_Homo sapiens_hsa001002.41405900
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.41253677
7Long-term potentiation_Homo sapiens_hsa047202.38713575
8Olfactory transduction_Homo sapiens_hsa047402.38579541
9Circadian entrainment_Homo sapiens_hsa047132.21462721
10Amphetamine addiction_Homo sapiens_hsa050312.20987381
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.12043239
12Dopaminergic synapse_Homo sapiens_hsa047282.11395534
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.10227224
14RNA transport_Homo sapiens_hsa030132.01511430
15Morphine addiction_Homo sapiens_hsa050321.97005565
16Basal transcription factors_Homo sapiens_hsa030221.95876639
17Collecting duct acid secretion_Homo sapiens_hsa049661.94463150
18GABAergic synapse_Homo sapiens_hsa047271.83692649
19Glutamatergic synapse_Homo sapiens_hsa047241.78157968
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.73469480
21Serotonergic synapse_Homo sapiens_hsa047261.65489730
22Axon guidance_Homo sapiens_hsa043601.61989251
23Vibrio cholerae infection_Homo sapiens_hsa051101.58800596
24Mismatch repair_Homo sapiens_hsa034301.55762689
25Fatty acid elongation_Homo sapiens_hsa000621.51178714
26Cholinergic synapse_Homo sapiens_hsa047251.48998862
27RNA degradation_Homo sapiens_hsa030181.47243077
28Taste transduction_Homo sapiens_hsa047421.43701840
29Cocaine addiction_Homo sapiens_hsa050301.40834195
30Insulin secretion_Homo sapiens_hsa049111.40356535
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.39429883
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.38035835
33Long-term depression_Homo sapiens_hsa047301.37830011
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.37592513
35Salivary secretion_Homo sapiens_hsa049701.37559756
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37430003
37Vitamin B6 metabolism_Homo sapiens_hsa007501.34030532
38ErbB signaling pathway_Homo sapiens_hsa040121.33394994
39Propanoate metabolism_Homo sapiens_hsa006401.33145713
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.33121398
41Oxytocin signaling pathway_Homo sapiens_hsa049211.29763811
42Glioma_Homo sapiens_hsa052141.28219375
43Spliceosome_Homo sapiens_hsa030401.26825313
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.24001408
45Gap junction_Homo sapiens_hsa045401.22734331
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.22050018
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.21078849
48* Oocyte meiosis_Homo sapiens_hsa041141.21054956
49Renin secretion_Homo sapiens_hsa049241.20224956
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.19313502
51Calcium signaling pathway_Homo sapiens_hsa040201.19113477
52Melanogenesis_Homo sapiens_hsa049161.16821164
53Aldosterone synthesis and secretion_Homo sapiens_hsa049251.16692624
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14460204
55Tight junction_Homo sapiens_hsa045301.14102758
56Neurotrophin signaling pathway_Homo sapiens_hsa047221.14064607
57p53 signaling pathway_Homo sapiens_hsa041151.11570314
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09523898
59Gastric acid secretion_Homo sapiens_hsa049711.09117387
60Fanconi anemia pathway_Homo sapiens_hsa034601.07603525
61GnRH signaling pathway_Homo sapiens_hsa049121.06038245
62Colorectal cancer_Homo sapiens_hsa052101.00378309
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98931342
64cAMP signaling pathway_Homo sapiens_hsa040240.98039796
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97924427
66Endometrial cancer_Homo sapiens_hsa052130.97891154
67* Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96673773
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95230672
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94900322
70Phototransduction_Homo sapiens_hsa047440.93020365
71Biosynthesis of amino acids_Homo sapiens_hsa012300.91171631
72Wnt signaling pathway_Homo sapiens_hsa043100.89879611
73Type I diabetes mellitus_Homo sapiens_hsa049400.89178655
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.87568823
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85795352
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85677584
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83070453
78Nucleotide excision repair_Homo sapiens_hsa034200.82293940
79Shigellosis_Homo sapiens_hsa051310.81852954
80Estrogen signaling pathway_Homo sapiens_hsa049150.81261694
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80540849
82Circadian rhythm_Homo sapiens_hsa047100.78792401
83Non-small cell lung cancer_Homo sapiens_hsa052230.78620920
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77793034
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77309603
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76065208
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75617769
88Alcoholism_Homo sapiens_hsa050340.75223367
89TGF-beta signaling pathway_Homo sapiens_hsa043500.75099707
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73924792
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73596765
92Phagosome_Homo sapiens_hsa041450.72880264
93Basal cell carcinoma_Homo sapiens_hsa052170.71974970
94Hedgehog signaling pathway_Homo sapiens_hsa043400.71785968
95Proteoglycans in cancer_Homo sapiens_hsa052050.71517574
96* Hippo signaling pathway_Homo sapiens_hsa043900.71513729
97Carbon metabolism_Homo sapiens_hsa012000.70945342
98MAPK signaling pathway_Homo sapiens_hsa040100.70822285
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70486265
100VEGF signaling pathway_Homo sapiens_hsa043700.68402574
101Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67478394
102Selenocompound metabolism_Homo sapiens_hsa004500.66696188
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66434533
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66250829
105mRNA surveillance pathway_Homo sapiens_hsa030150.66132240
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.65292568
107Legionellosis_Homo sapiens_hsa051340.64888645
108Ras signaling pathway_Homo sapiens_hsa040140.64521111
109Pyruvate metabolism_Homo sapiens_hsa006200.61397980
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60757707
111Rap1 signaling pathway_Homo sapiens_hsa040150.60449246
112Proteasome_Homo sapiens_hsa030500.59481759
113RNA polymerase_Homo sapiens_hsa030200.59085397
114MicroRNAs in cancer_Homo sapiens_hsa052060.57505244
115N-Glycan biosynthesis_Homo sapiens_hsa005100.57329357
116Renal cell carcinoma_Homo sapiens_hsa052110.57219883
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57021868
118Rheumatoid arthritis_Homo sapiens_hsa053230.56949622
119Choline metabolism in cancer_Homo sapiens_hsa052310.56484694
120Type II diabetes mellitus_Homo sapiens_hsa049300.55978984
121Salmonella infection_Homo sapiens_hsa051320.54682393
122T cell receptor signaling pathway_Homo sapiens_hsa046600.53520938
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53173714
124Melanoma_Homo sapiens_hsa052180.53087139
125Sphingolipid metabolism_Homo sapiens_hsa006000.52255000
126Cardiac muscle contraction_Homo sapiens_hsa042600.51893051
127Inositol phosphate metabolism_Homo sapiens_hsa005620.51819606
128Sulfur metabolism_Homo sapiens_hsa009200.50535693
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50113829
130Dorso-ventral axis formation_Homo sapiens_hsa043200.49307383
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49162426
132Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48487070
133Thyroid cancer_Homo sapiens_hsa052160.47971277
134Alzheimers disease_Homo sapiens_hsa050100.47560817
135Chemokine signaling pathway_Homo sapiens_hsa040620.47511872
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.47478124
137Oxidative phosphorylation_Homo sapiens_hsa001900.47218085
138Base excision repair_Homo sapiens_hsa034100.44453814
139* Cell cycle_Homo sapiens_hsa041100.44425078
140Dilated cardiomyopathy_Homo sapiens_hsa054140.44254049
141Parkinsons disease_Homo sapiens_hsa050120.43814669
142Adherens junction_Homo sapiens_hsa045200.42903441
143Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42706511
144Endocytosis_Homo sapiens_hsa041440.42453500
145Prolactin signaling pathway_Homo sapiens_hsa049170.42400917
146Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41741305
147Pyrimidine metabolism_Homo sapiens_hsa002400.41315619
148Pancreatic cancer_Homo sapiens_hsa052120.41276024
149Sphingolipid signaling pathway_Homo sapiens_hsa040710.41207637
150Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40742359
151Prostate cancer_Homo sapiens_hsa052150.40633177
152Thyroid hormone synthesis_Homo sapiens_hsa049180.40388779
153DNA replication_Homo sapiens_hsa030300.40119268
154Pentose phosphate pathway_Homo sapiens_hsa000300.39120125
155Fatty acid metabolism_Homo sapiens_hsa012120.34880811

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