ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	water-soluble vitamin biosynthetic process (GO:0042364)	5.16862147
2	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	4.82839742
3	regulation of isotype switching to IgG isotypes (GO:0048302)	4.62876661
4	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	4.46661816
5	regulation of immunoglobulin secretion (GO:0051023)	4.31818393
6	proteasome assembly (GO:0043248)	4.23853865
7	negative regulation of acute inflammatory response (GO:0002674)	4.07234926
8	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.93305381
9	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.93305381
10	behavioral response to nicotine (GO:0035095)	3.88763098
11	L-fucose catabolic process (GO:0042355)	3.66721802
12	fucose catabolic process (GO:0019317)	3.66721802
13	L-fucose metabolic process (GO:0042354)	3.66721802
14	regulation of regulatory T cell differentiation (GO:0045589)	3.61649370
15	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.59495190
16	ATP synthesis coupled proton transport (GO:0015986)	3.59495190
17	protein neddylation (GO:0045116)	3.57793569
18	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.55200367
19	DNA deamination (GO:0045006)	3.51784702
20	GTP biosynthetic process (GO:0006183)	3.51482041
21	respiratory chain complex IV assembly (GO:0008535)	3.48735359
22	negative regulation of telomere maintenance (GO:0032205)	3.41717914
23	positive regulation of DNA recombination (GO:0045911)	3.39028564
24	protein complex biogenesis (GO:0070271)	3.38257288
25	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.35238424
26	platelet dense granule organization (GO:0060155)	3.35115325
27	folic acid-containing compound biosynthetic process (GO:0009396)	3.32675521
28	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.30487606
29	signal peptide processing (GO:0006465)	3.28877465
30	regulation of vitamin D biosynthetic process (GO:0060556)	3.24102655
31	positive regulation of interleukin-17 production (GO:0032740)	3.23320706
32	amino acid salvage (GO:0043102)	3.23232815
33	L-methionine salvage (GO:0071267)	3.23232815
34	L-methionine biosynthetic process (GO:0071265)	3.23232815
35	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.12430699
36	pteridine-containing compound biosynthetic process (GO:0042559)	3.11010180
37	adenosine metabolic process (GO:0046085)	3.07922259
38	artery smooth muscle contraction (GO:0014824)	3.03368039
39	regulation of memory T cell differentiation (GO:0043380)	3.00502154
40	peptidyl-histidine modification (GO:0018202)	2.99689504
41	preassembly of GPI anchor in ER membrane (GO:0016254)	2.98836830
42	mitochondrial respiratory chain complex assembly (GO:0033108)	2.98497754
43	positive regulation of isotype switching (GO:0045830)	2.98401690
44	cytochrome complex assembly (GO:0017004)	2.97015071
45	aggressive behavior (GO:0002118)	2.88673898
46	S-adenosylmethionine metabolic process (GO:0046500)	2.88545354
47	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.83653976
48	response to pheromone (GO:0019236)	2.81679173
49	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.80483511
50	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.80483511
51	NADH dehydrogenase complex assembly (GO:0010257)	2.80483511
52	UTP biosynthetic process (GO:0006228)	2.77488985
53	positive regulation of glycolytic process (GO:0045821)	2.77136220
54	pseudouridine synthesis (GO:0001522)	2.74774496
55	tRNA processing (GO:0008033)	2.74176089
56	UTP metabolic process (GO:0046051)	2.73954398
57	inositol phosphate-mediated signaling (GO:0048016)	2.73274663
58	DNA double-strand break processing (GO:0000729)	2.70441864
59	electron transport chain (GO:0022900)	2.69936239
60	tonic smooth muscle contraction (GO:0014820)	2.67954791
61	respiratory electron transport chain (GO:0022904)	2.67460177
62	positive regulation of prostaglandin secretion (GO:0032308)	2.63003543
63	regulation of endothelial cell differentiation (GO:0045601)	2.61979668
64	nitric oxide mediated signal transduction (GO:0007263)	2.60835411
65	hydrogen ion transmembrane transport (GO:1902600)	2.59604565
66	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.59565734
67	regulation of vitamin metabolic process (GO:0030656)	2.54498908
68	positive regulation of fatty acid transport (GO:2000193)	2.52697660
69	adaptation of signaling pathway (GO:0023058)	2.52503744
70	proton transport (GO:0015992)	2.50817480
71	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.50376002
72	positive regulation of cell fate commitment (GO:0010455)	2.49333469
73	regulation of cellular amino acid metabolic process (GO:0006521)	2.46932875
74	cellular ketone body metabolic process (GO:0046950)	2.46318259
75	nucleoside diphosphate phosphorylation (GO:0006165)	2.45639502
76	regulation of cytokine production involved in inflammatory response (GO:1900015)	2.45118352
77	hydrogen transport (GO:0006818)	2.43451635
78	prenylation (GO:0097354)	2.43049333
79	protein prenylation (GO:0018342)	2.43049333
80	negative regulation of B cell apoptotic process (GO:0002903)	2.42469126
81	positive regulation of immunoglobulin mediated immune response (GO:0002891)	2.37664354
82	positive regulation of B cell mediated immunity (GO:0002714)	2.37664354
83	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.35442985
84	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	2.35322900
85	positive regulation of defense response to virus by host (GO:0002230)	2.34318911
86	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	2.33799990
87	replication fork processing (GO:0031297)	2.33254479
88	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.32829180
89	ATP hydrolysis coupled proton transport (GO:0015991)	2.32829180
90	regulation of B cell apoptotic process (GO:0002902)	2.32619322
91	xenobiotic catabolic process (GO:0042178)	2.31491186
92	regulation of action potential (GO:0098900)	2.29048033
93	guanosine-containing compound biosynthetic process (GO:1901070)	2.28280479
94	inositol phosphate dephosphorylation (GO:0046855)	2.28142689
95	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.28142689
96	mannosylation (GO:0097502)	2.27305840
97	regulation of meiosis I (GO:0060631)	2.26447419
98	vitamin biosynthetic process (GO:0009110)	2.25613089
99	intracellular protein transmembrane import (GO:0044743)	2.25071803
100	positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)	2.24936904

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.91130909
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.61282749
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.42916623
4	FLI1_27457419_Chip-Seq_LIVER_Mouse	3.34510019
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.02543476
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.88328625
7	VDR_22108803_ChIP-Seq_LS180_Human	2.64804101
8	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.62570802
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.54047306
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.43900234
11	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.40629657
12	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.26103381
13	ELK1_19687146_ChIP-ChIP_HELA_Human	2.14926748
14	GBX2_23144817_ChIP-Seq_PC3_Human	2.06288069
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.04226041
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.00666461
17	EWS_26573619_Chip-Seq_HEK293_Human	1.99324987
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.97870428
19	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.90029769
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.86939123
21	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.86429212
22	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.83032021
23	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.80911545
24	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.79119209
25	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.78445004
26	TAF15_26573619_Chip-Seq_HEK293_Human	1.78388487
27	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.77129515
28	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.75379709
29	P300_19829295_ChIP-Seq_ESCs_Human	1.74113779
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.73340314
31	IGF1R_20145208_ChIP-Seq_DFB_Human	1.73062817
32	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.69175965
33	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.66152346
34	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.64821087
35	FUS_26573619_Chip-Seq_HEK293_Human	1.63127622
36	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.60588553
37	FOXP3_21729870_ChIP-Seq_TREG_Human	1.58651368
38	NANOG_19829295_ChIP-Seq_ESCs_Human	1.58081076
39	SOX2_19829295_ChIP-Seq_ESCs_Human	1.58081076
40	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.54917949
41	ER_23166858_ChIP-Seq_MCF-7_Human	1.54779353
42	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.54669891
43	BCAT_22108803_ChIP-Seq_LS180_Human	1.54382831
44	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.50636731
45	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.45768813
46	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.44249227
47	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.42055953
48	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.38625619
49	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.37021137
50	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.34361748
51	CDX2_22108803_ChIP-Seq_LS180_Human	1.32190543
52	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.27995489
53	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.27995489
54	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.26737168
55	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.26411068
56	GATA3_26560356_Chip-Seq_TH2_Human	1.24330046
57	TCF4_22108803_ChIP-Seq_LS180_Human	1.24267727
58	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.22349274
59	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.21127257
60	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.19153061
61	CBP_20019798_ChIP-Seq_JUKART_Human	1.19153061
62	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.18781143
63	P300_18555785_Chip-Seq_ESCs_Mouse	1.17864274
64	P53_22387025_ChIP-Seq_ESCs_Mouse	1.16840803
65	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.15270195
66	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.13616612
67	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.12931653
68	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.12722469
69	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.11917709
70	AR_20517297_ChIP-Seq_VCAP_Human	1.11373130
71	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.11208681
72	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.11142036
73	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.10313900
74	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.09884202
75	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.07877642
76	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.07536429
77	MYC_18940864_ChIP-ChIP_HL60_Human	1.07009392
78	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.06403368
79	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.05976658
80	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.05235183
81	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.04508607
82	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.03699312
83	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.03491511
84	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.02888917
85	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.02738633
86	STAT3_23295773_ChIP-Seq_U87_Human	1.02687510
87	SMAD4_21799915_ChIP-Seq_A2780_Human	1.02285078
88	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01180180
89	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.01091221
90	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.00175114
91	CTCF_18555785_Chip-Seq_ESCs_Mouse	0.99759351
92	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.97577816
93	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.97396953
94	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.96723084
95	NCOR_22424771_ChIP-Seq_293T_Human	0.96620197
96	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.96057865
97	TCF4_23295773_ChIP-Seq_U87_Human	0.95645509
98	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.95465025
99	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.95390981
100	RUNX1_27457419_Chip-Seq_LIVER_Mouse	0.94271442

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	3.33755634
2	MP0001986_abnormal_taste_sensitivity	3.20270886
3	MP0005360_urolithiasis	2.84556875
4	MP0008875_abnormal_xenobiotic_pharmacok	2.82314834
5	MP0001835_abnormal_antigen_presentation	2.81971237
6	MP0002736_abnormal_nociception_after	2.64384469
7	MP0008877_abnormal_DNA_methylation	2.55637309
8	MP0000569_abnormal_digit_pigmentation	2.49905515
9	MP0008872_abnormal_physiological_respon	2.45741641
10	MP0005646_abnormal_pituitary_gland	2.43274533
11	MP0001968_abnormal_touch/_nociception	2.32951259
12	MP0004885_abnormal_endolymph	2.29411212
13	MP0003195_calcinosis	2.29202002
14	MP0005084_abnormal_gallbladder_morpholo	2.14193489
15	MP0005075_abnormal_melanosome_morpholog	1.97224018
16	MP0005671_abnormal_response_to	1.88295046
17	MP0006072_abnormal_retinal_apoptosis	1.85768092
18	MP0005551_abnormal_eye_electrophysiolog	1.81814146
19	MP0004147_increased_porphyrin_level	1.79388622
20	MP0009780_abnormal_chondrocyte_physiolo	1.78452352
21	MP0003646_muscle_fatigue	1.75643912
22	MP0004142_abnormal_muscle_tone	1.74888884
23	MP0006054_spinal_hemorrhage	1.73837593
24	MP0002254_reproductive_system_inflammat	1.70596520
25	MP0002876_abnormal_thyroid_physiology	1.66934477
26	MP0004043_abnormal_pH_regulation	1.63671861
27	MP0001873_stomach_inflammation	1.62079342
28	MP0002148_abnormal_hypersensitivity_rea	1.61697587
29	MP0000372_irregular_coat_pigmentation	1.60405227
30	MP0003806_abnormal_nucleotide_metabolis	1.59263530
31	MP0005253_abnormal_eye_physiology	1.50838828
32	MP0001661_extended_life_span	1.50475839
33	MP0002938_white_spotting	1.47822365
34	MP0005332_abnormal_amino_acid	1.43961302
35	MP0005387_immune_system_phenotype	1.43712379
36	MP0001790_abnormal_immune_system	1.43712379
37	MP0002693_abnormal_pancreas_physiology	1.38813670
38	MP0003186_abnormal_redox_activity	1.38653431
39	MP0009785_altered_susceptibility_to	1.36531963
40	MP0005367_renal/urinary_system_phenotyp	1.35137575
41	MP0000516_abnormal_urinary_system	1.35137575
42	MP0005167_abnormal_blood-brain_barrier	1.34230772
43	MP0009046_muscle_twitch	1.32252771
44	MP0004215_abnormal_myocardial_fiber	1.30968662
45	MP0002272_abnormal_nervous_system	1.30276743
46	MP0002138_abnormal_hepatobiliary_system	1.30034176
47	MP0009745_abnormal_behavioral_response	1.28746073
48	MP0005636_abnormal_mineral_homeostasis	1.28056362
49	MP0000013_abnormal_adipose_tissue	1.26393891
50	MP0004145_abnormal_muscle_electrophysio	1.22213726
51	MP0005410_abnormal_fertilization	1.21549127
52	MP0001501_abnormal_sleep_pattern	1.20633834
53	MP0003011_delayed_dark_adaptation	1.14212842
54	MP0003283_abnormal_digestive_organ	1.14117166
55	MP0004084_abnormal_cardiac_muscle	1.12643944
56	MP0001800_abnormal_humoral_immune	1.12162379
57	MP0002095_abnormal_skin_pigmentation	1.10909639
58	MP0002163_abnormal_gland_morphology	1.10353479
59	MP0006036_abnormal_mitochondrial_physio	1.09346857
60	MP0003724_increased_susceptibility_to	1.05904714
61	MP0010386_abnormal_urinary_bladder	1.05729165
62	MP0005464_abnormal_platelet_physiology	1.04081321
63	MP0008775_abnormal_heart_ventricle	1.03291882
64	MP0005085_abnormal_gallbladder_physiolo	1.01605521
65	MP0001756_abnormal_urination	1.01132593
66	MP0003786_premature_aging	1.00495588
67	MP0006082_CNS_inflammation	0.99099381
68	MP0000230_abnormal_systemic_arterial	0.98856924
69	MP0001486_abnormal_startle_reflex	0.98827284
70	MP0005310_abnormal_salivary_gland	0.97513331
71	MP0001485_abnormal_pinna_reflex	0.96985008
72	MP0005000_abnormal_immune_tolerance	0.96441402
73	MP0004742_abnormal_vestibular_system	0.95420248
74	MP0000685_abnormal_immune_system	0.93666106
75	MP0001853_heart_inflammation	0.93364669
76	MP0005083_abnormal_biliary_tract	0.92516587
77	MP0005174_abnormal_tail_pigmentation	0.92370174
78	MP0003866_abnormal_defecation	0.92233315
79	MP0002933_joint_inflammation	0.91333415
80	MP0001502_abnormal_circadian_rhythm	0.90660587
81	MP0001765_abnormal_ion_homeostasis	0.90650541
82	MP0003045_fibrosis	0.88650595
83	MP0001764_abnormal_homeostasis	0.88365577
84	MP0002229_neurodegeneration	0.87381654
85	MP0002006_tumorigenesis	0.86621053
86	MP0002166_altered_tumor_susceptibility	0.86599725
87	MP0003633_abnormal_nervous_system	0.84803531
88	MP0004484_altered_response_of	0.84697439
89	MP0005645_abnormal_hypothalamus_physiol	0.82660556
90	MP0000015_abnormal_ear_pigmentation	0.82574959
91	MP0005670_abnormal_white_adipose	0.82509180
92	MP0005187_abnormal_penis_morphology	0.81002634
93	MP0009697_abnormal_copulation	0.80929751
94	MP0000538_abnormal_urinary_bladder	0.80041304
95	MP0001348_abnormal_lacrimal_gland	0.78305861
96	MP0000465_gastrointestinal_hemorrhage	0.77955683
97	MP0001944_abnormal_pancreas_morphology	0.77359706
98	MP0003252_abnormal_bile_duct	0.77298292
99	MP0010329_abnormal_lipoprotein_level	0.76891154
100	MP0002723_abnormal_immune_serum	0.75487883

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.67414235
2	Abnormality of alanine metabolism (HP:0010916)	3.67414235
3	Hyperalaninemia (HP:0003348)	3.67414235
4	Congenital, generalized hypertrichosis (HP:0004540)	3.66839068
5	Acute necrotizing encephalopathy (HP:0006965)	3.64264172
6	Renal cortical cysts (HP:0000803)	3.63680961
7	Tongue fasciculations (HP:0001308)	3.56230449
8	Increased CSF lactate (HP:0002490)	3.38105302
9	Mitochondrial inheritance (HP:0001427)	3.34505549
10	Progressive macrocephaly (HP:0004481)	3.28280322
11	Acute encephalopathy (HP:0006846)	3.20235647
12	3-Methylglutaconic aciduria (HP:0003535)	3.20141447
13	Abnormality of the renal cortex (HP:0011035)	3.15756292
14	Stomatitis (HP:0010280)	3.13083334
15	Lipid accumulation in hepatocytes (HP:0006561)	3.05055050
16	Abnormal mitochondria in muscle tissue (HP:0008316)	3.01184803
17	Methylmalonic acidemia (HP:0002912)	2.96345438
18	Pancreatic cysts (HP:0001737)	2.93755357
19	Muscle fibrillation (HP:0010546)	2.93489515
20	Hepatic necrosis (HP:0002605)	2.91354677
21	Increased hepatocellular lipid droplets (HP:0006565)	2.90467684
22	Hepatocellular necrosis (HP:0001404)	2.82814722
23	Nephronophthisis (HP:0000090)	2.77948028
24	Exertional dyspnea (HP:0002875)	2.77568111
25	Constricted visual fields (HP:0001133)	2.70377869
26	Generalized aminoaciduria (HP:0002909)	2.69425656
27	Congenital sensorineural hearing impairment (HP:0008527)	2.69356428
28	Hypomagnesemia (HP:0002917)	2.68810116
29	Hypothermia (HP:0002045)	2.63418249
30	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.62694810
31	Abolished electroretinogram (ERG) (HP:0000550)	2.60157971
32	Large for gestational age (HP:0001520)	2.56711462
33	Renal Fanconi syndrome (HP:0001994)	2.46217547
34	Increased serum lactate (HP:0002151)	2.46100454
35	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.44826351
36	Methylmalonic aciduria (HP:0012120)	2.40873943
37	Molar tooth sign on MRI (HP:0002419)	2.39445183
38	Abnormality of midbrain morphology (HP:0002418)	2.39445183
39	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.36646675
40	Abnormality of the pons (HP:0007361)	2.33022657
41	Hypoglycemic coma (HP:0001325)	2.33009618
42	Pancreatic fibrosis (HP:0100732)	2.32112284
43	Ketoacidosis (HP:0001993)	2.31995337
44	True hermaphroditism (HP:0010459)	2.29345342
45	Abnormality of the renal medulla (HP:0100957)	2.27055645
46	Cerebral edema (HP:0002181)	2.25104156
47	Glycosuria (HP:0003076)	2.24695302
48	Abnormality of urine glucose concentration (HP:0011016)	2.24695302
49	Congenital stationary night blindness (HP:0007642)	2.22679306
50	Attenuation of retinal blood vessels (HP:0007843)	2.21416319
51	Hyperglycemia (HP:0003074)	2.19713410
52	Abnormality of magnesium homeostasis (HP:0004921)	2.13970922
53	Abnormality of B cell number (HP:0010975)	2.13887852
54	Polydipsia (HP:0001959)	2.13340948
55	Abnormal drinking behavior (HP:0030082)	2.13340948
56	Optic disc pallor (HP:0000543)	2.12400213
57	B lymphocytopenia (HP:0010976)	2.11646531
58	IgG deficiency (HP:0004315)	2.09048032
59	Progressive inability to walk (HP:0002505)	2.08512243
60	Disproportionate short-trunk short stature (HP:0003521)	2.06713780
61	Lactic acidosis (HP:0003128)	2.06590228
62	Aplasia/hypoplasia of the uterus (HP:0008684)	2.04000248
63	Hyperinsulinemic hypoglycemia (HP:0000825)	2.02477428
64	Lethargy (HP:0001254)	2.01582276
65	Elevated erythrocyte sedimentation rate (HP:0003565)	2.01165364
66	Dicarboxylic aciduria (HP:0003215)	1.98361232
67	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.98361232
68	Respiratory failure (HP:0002878)	1.96614229
69	Ketosis (HP:0001946)	1.94148181
70	Chorioretinal atrophy (HP:0000533)	1.93893331
71	Abnormality of serum amino acid levels (HP:0003112)	1.93865477
72	Hyperglycinemia (HP:0002154)	1.90350832
73	Progressive microcephaly (HP:0000253)	1.88873488
74	Abnormality of vitamin B metabolism (HP:0004340)	1.87482001
75	Patchy hypopigmentation of hair (HP:0011365)	1.85304192
76	Inability to walk (HP:0002540)	1.83886004
77	Poor speech (HP:0002465)	1.82390995
78	Hypoplasia of the pons (HP:0012110)	1.82025557
79	Type I transferrin isoform profile (HP:0003642)	1.81681457
80	Leukodystrophy (HP:0002415)	1.79944778
81	Hypoproteinemia (HP:0003075)	1.79439878
82	Abnormal pupillary function (HP:0007686)	1.78365718
83	Chronic diarrhea (HP:0002028)	1.77204822
84	Abnormality of renal resorption (HP:0011038)	1.74525745
85	Recurrent cutaneous fungal infections (HP:0011370)	1.73838266
86	Chronic mucocutaneous candidiasis (HP:0002728)	1.73838266
87	Palpitations (HP:0001962)	1.72469614
88	Anorexia (HP:0002039)	1.71573804
89	Increased corneal curvature (HP:0100692)	1.70374967
90	Keratoconus (HP:0000563)	1.70374967
91	Pendular nystagmus (HP:0012043)	1.67077150
92	Abnormality of glycine metabolism (HP:0010895)	1.67040607
93	Abnormality of serine family amino acid metabolism (HP:0010894)	1.67040607
94	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.66700335
95	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.66700335
96	Furrowed tongue (HP:0000221)	1.64110018
97	Nausea (HP:0002018)	1.63534558
98	Hyperphosphaturia (HP:0003109)	1.62763025
99	Metabolic acidosis (HP:0001942)	1.62403964
100	Abnormal biliary tract physiology (HP:0012439)	1.61541738

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	3.92322917
2	BMPR1B	3.53296953
3	EIF2AK1	3.44522940
4	FRK	3.21291595
5	EIF2AK3	2.79306851
6	TRIM28	2.51953093
7	TLK1	2.24016544
8	MST4	2.20146453
9	ADRBK2	2.15495707
10	TSSK6	2.06829395
11	ACVR1B	2.06124726
12	OXSR1	2.03035143
13	MAP4K2	1.90451313
14	VRK2	1.89263241
15	NEK1	1.87969431
16	STK39	1.81901872
17	MAP2K6	1.80794146
18	GRK1	1.72470776
19	TIE1	1.69804451
20	ZAK	1.68777679
21	MAP3K12	1.61782713
22	WNK4	1.61210979
23	NUAK1	1.53592693
24	TEC	1.53243791
25	PHKG1	1.44278937
26	PHKG2	1.44278937
27	MAP4K1	1.42188282
28	MYLK	1.35469476
29	VRK1	1.34500267
30	PAK3	1.31253702
31	SIK3	1.29367460
32	TAF1	1.27252881
33	PLK2	1.22853961
34	PINK1	1.15491823
35	PASK	1.06753399
36	BMPR2	1.04428984
37	MKNK2	1.01497600
38	IKBKB	0.99891327
39	ADRBK1	0.99678316
40	ITK	0.99428609
41	TNIK	0.98651484
42	EIF2AK2	0.98329313
43	PLK3	0.96025480
44	PTK2B	0.94172350
45	TGFBR1	0.89957907
46	DAPK2	0.89119203
47	PNCK	0.88687144
48	INSRR	0.87605547
49	WNK3	0.82916181
50	PBK	0.82142426
51	PRKCE	0.78189212
52	BCR	0.76617739
53	DAPK1	0.75793650
54	TAOK3	0.72031508
55	CSNK1G1	0.70144510
56	FLT3	0.68111754
57	CSNK1G3	0.67490379
58	STK38L	0.66276265
59	KIT	0.62830557
60	NEK9	0.60330136
61	RPS6KA5	0.60211233
62	STK4	0.59460512
63	CDK9	0.59054027
64	MAP3K3	0.58759046
65	MINK1	0.58183461
66	TNK2	0.57500887
67	WEE1	0.57429051
68	CAMK2D	0.55009376
69	SYK	0.53217484
70	PRKG2	0.52352840
71	CSNK1G2	0.51081745
72	CSNK1A1	0.50501410
73	CAMK2A	0.50371587
74	CSNK1A1L	0.47828448
75	IGF1R	0.45762610
76	GRK5	0.42729032
77	BLK	0.42346403
78	JAK3	0.41640259
79	IRAK1	0.41025871
80	PRKCG	0.39987344
81	ERBB3	0.39084989
82	DAPK3	0.38779354
83	MKNK1	0.38768569
84	CSF1R	0.37990647
85	PRKG1	0.37316183
86	CHUK	0.36830227
87	LYN	0.34927828
88	LCK	0.34697108
89	CLK1	0.34303055
90	CDK3	0.33569449
91	MUSK	0.32866180
92	FES	0.32217946
93	PRKACA	0.32051852
94	HIPK2	0.31959915
95	DYRK2	0.30571147
96	FER	0.30249094
97	EGFR	0.30061386
98	ILK	0.29819663
99	BCKDK	0.29727033
100	PRKCA	0.28753309

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.29738799
2	Protein export_Homo sapiens_hsa03060	3.29441336
3	Proteasome_Homo sapiens_hsa03050	3.21270369
4	Oxidative phosphorylation_Homo sapiens_hsa00190	3.16030189
5	Sulfur metabolism_Homo sapiens_hsa00920	2.99028725
6	Caffeine metabolism_Homo sapiens_hsa00232	2.31132004
7	Asthma_Homo sapiens_hsa05310	2.27252324
8	Allograft rejection_Homo sapiens_hsa05330	2.21753290
9	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.21111505
10	Parkinsons disease_Homo sapiens_hsa05012	2.19971100
11	Type I diabetes mellitus_Homo sapiens_hsa04940	2.11647988
12	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.07665901
13	Regulation of autophagy_Homo sapiens_hsa04140	2.03384015
14	Basal transcription factors_Homo sapiens_hsa03022	1.99372747
15	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.94833245
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.93116508
17	Collecting duct acid secretion_Homo sapiens_hsa04966	1.87060793
18	One carbon pool by folate_Homo sapiens_hsa00670	1.74989852
19	Phototransduction_Homo sapiens_hsa04744	1.70595270
20	Nitrogen metabolism_Homo sapiens_hsa00910	1.65687977
21	Homologous recombination_Homo sapiens_hsa03440	1.65233068
22	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.64039203
23	Graft-versus-host disease_Homo sapiens_hsa05332	1.63876830
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.50264237
25	Alzheimers disease_Homo sapiens_hsa05010	1.40322190
26	Huntingtons disease_Homo sapiens_hsa05016	1.34947674
27	Rheumatoid arthritis_Homo sapiens_hsa05323	1.33787200
28	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.32587180
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.32215437
30	Butanoate metabolism_Homo sapiens_hsa00650	1.31909047
31	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.26808493
32	RNA polymerase_Homo sapiens_hsa03020	1.22672961
33	Selenocompound metabolism_Homo sapiens_hsa00450	1.21653697
34	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.19391331
35	Propanoate metabolism_Homo sapiens_hsa00640	1.17258053
36	RNA degradation_Homo sapiens_hsa03018	1.16526406
37	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.09860680
38	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.06339799
39	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.05750190
40	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.05691997
41	Tryptophan metabolism_Homo sapiens_hsa00380	1.03066441
42	Peroxisome_Homo sapiens_hsa04146	0.99064929
43	Cardiac muscle contraction_Homo sapiens_hsa04260	0.96966326
44	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.96116828
45	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.95916285
46	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.91174467
47	Fanconi anemia pathway_Homo sapiens_hsa03460	0.85741577
48	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.83790225
49	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.81003818
50	Olfactory transduction_Homo sapiens_hsa04740	0.79787819
51	Mineral absorption_Homo sapiens_hsa04978	0.78485843
52	Nicotine addiction_Homo sapiens_hsa05033	0.78180862
53	Insulin secretion_Homo sapiens_hsa04911	0.76673493
54	Primary immunodeficiency_Homo sapiens_hsa05340	0.75047381
55	Non-homologous end-joining_Homo sapiens_hsa03450	0.74892869
56	Purine metabolism_Homo sapiens_hsa00230	0.74663659
57	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.73690966
58	Chemical carcinogenesis_Homo sapiens_hsa05204	0.73141954
59	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.71574524
60	Ether lipid metabolism_Homo sapiens_hsa00565	0.70702554
61	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.69104399
62	Fatty acid elongation_Homo sapiens_hsa00062	0.66858385
63	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.66510454
64	beta-Alanine metabolism_Homo sapiens_hsa00410	0.66433972
65	Retinol metabolism_Homo sapiens_hsa00830	0.64606853
66	Pyrimidine metabolism_Homo sapiens_hsa00240	0.62911007
67	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.62184487
68	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.61939835
69	Morphine addiction_Homo sapiens_hsa05032	0.61508017
70	Mismatch repair_Homo sapiens_hsa03430	0.60005302
71	Metabolic pathways_Homo sapiens_hsa01100	0.59341523
72	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.58341372
73	Circadian rhythm_Homo sapiens_hsa04710	0.57463606
74	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.57085189
75	Nucleotide excision repair_Homo sapiens_hsa03420	0.55112136
76	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.54144210
77	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.52923966
78	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.52664825
79	Fatty acid metabolism_Homo sapiens_hsa01212	0.51657952
80	Salivary secretion_Homo sapiens_hsa04970	0.51285933
81	Circadian entrainment_Homo sapiens_hsa04713	0.51067447
82	Folate biosynthesis_Homo sapiens_hsa00790	0.49259383
83	Fatty acid degradation_Homo sapiens_hsa00071	0.49231634
84	Glutathione metabolism_Homo sapiens_hsa00480	0.48269412
85	GABAergic synapse_Homo sapiens_hsa04727	0.46876778
86	Serotonergic synapse_Homo sapiens_hsa04726	0.46393576
87	Taste transduction_Homo sapiens_hsa04742	0.43269034
88	RNA transport_Homo sapiens_hsa03013	0.43242195
89	Spliceosome_Homo sapiens_hsa03040	0.43171151
90	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.39950019
91	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.38934735
92	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.38261946
93	ABC transporters_Homo sapiens_hsa02010	0.34976431
94	Fat digestion and absorption_Homo sapiens_hsa04975	0.34932334
95	Ribosome_Homo sapiens_hsa03010	0.34539065
96	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.34333451
97	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.32268760
98	Arginine and proline metabolism_Homo sapiens_hsa00330	0.31765803
99	Glutamatergic synapse_Homo sapiens_hsa04724	0.31630659
100	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.31078008

YWHAZP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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