YWHAZP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.44299067
2cytidine metabolic process (GO:0046087)6.68351409
3cytidine catabolic process (GO:0006216)6.68351409
4cytidine deamination (GO:0009972)6.68351409
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.04516117
6pyrimidine ribonucleoside catabolic process (GO:0046133)5.89321238
7positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.19372153
8protein neddylation (GO:0045116)5.10398559
9positive regulation of natural killer cell mediated immunity (GO:0002717)5.09192857
10regulation of chronic inflammatory response (GO:0002676)4.36449068
11cellular response to interleukin-15 (GO:0071350)4.34605308
12Arp2/3 complex-mediated actin nucleation (GO:0034314)4.29617243
13regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.08224442
14regulation of natural killer cell mediated immunity (GO:0002715)4.08224442
15sequestering of actin monomers (GO:0042989)3.99325641
16positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.95650947
17proteasome assembly (GO:0043248)3.88170952
18actin nucleation (GO:0045010)3.84167506
19regulation of cellular amino acid metabolic process (GO:0006521)3.80374251
20DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.54125269
21regulation of leukocyte mediated cytotoxicity (GO:0001910)3.52378390
22L-fucose catabolic process (GO:0042355)3.49707547
23fucose catabolic process (GO:0019317)3.49707547
24L-fucose metabolic process (GO:0042354)3.49707547
25negative regulation of T cell apoptotic process (GO:0070233)3.49048189
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.43165776
27intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.42361377
28signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.42361377
29positive regulation of cell killing (GO:0031343)3.42330281
30signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.42202573
31signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.42202573
32signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.42202573
33negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.37983484
34regulation of isotype switching to IgG isotypes (GO:0048302)3.37750060
35response to interleukin-15 (GO:0070672)3.36694460
36positive regulation of natural killer cell differentiation (GO:0032825)3.30971051
37energy coupled proton transport, down electrochemical gradient (GO:0015985)3.29795604
38ATP synthesis coupled proton transport (GO:0015986)3.29795604
39regulation of regulatory T cell differentiation (GO:0045589)3.27573605
40signal transduction involved in DNA integrity checkpoint (GO:0072401)3.22609582
41signal transduction involved in DNA damage checkpoint (GO:0072422)3.22609582
42pyrimidine nucleoside catabolic process (GO:0046135)3.19625529
43signal transduction involved in cell cycle checkpoint (GO:0072395)3.19216261
44positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.17503633
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.11537539
46positive regulation of interleukin-8 secretion (GO:2000484)3.07772227
47regulation of cell killing (GO:0031341)3.05636206
48response to pheromone (GO:0019236)3.03687454
49negative regulation by host of viral transcription (GO:0043922)3.01930515
50regulation of T cell receptor signaling pathway (GO:0050856)3.00368044
51positive regulation of interleukin-17 production (GO:0032740)2.99566074
52positive regulation of defense response to virus by host (GO:0002230)2.99106427
53negative regulation of ligase activity (GO:0051352)2.96507539
54negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.96507539
55regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.95822153
56protein deneddylation (GO:0000338)2.94957810
57mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.90317780
58eosinophil chemotaxis (GO:0048245)2.89680503
59positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.89256219
60negative T cell selection (GO:0043383)2.88420450
61antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.87552327
62negative regulation of calcium ion transport into cytosol (GO:0010523)2.86669292
63cullin deneddylation (GO:0010388)2.85677306
64regulation of interleukin-8 secretion (GO:2000482)2.85137304
65positive regulation of tolerance induction (GO:0002645)2.80398400
66positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.80395615
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.76915035
68tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.76915035
69activated T cell proliferation (GO:0050798)2.76444059
70positive regulation of ligase activity (GO:0051351)2.76156238
71DNA double-strand break processing (GO:0000729)2.74350649
72mast cell activation (GO:0045576)2.73388355
73positive regulation of T cell mediated cytotoxicity (GO:0001916)2.72330883
74negative regulation of lymphocyte apoptotic process (GO:0070229)2.69378087
75positive regulation of cell cycle arrest (GO:0071158)2.68944352
76anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.68481262
77regulation of cellular amine metabolic process (GO:0033238)2.68401114
78regulation of B cell receptor signaling pathway (GO:0050855)2.67408887
79negative regulation of telomere maintenance (GO:0032205)2.63831998
80negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.62718081
81DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.62496497
82interferon-gamma production (GO:0032609)2.61829880
83positive regulation of lymphocyte mediated immunity (GO:0002708)2.61084657
84eosinophil migration (GO:0072677)2.60548559
85establishment of protein localization to mitochondrial membrane (GO:0090151)2.60547507
86regulation of activation of Janus kinase activity (GO:0010533)2.59830710
87regulation of T cell mediated cytotoxicity (GO:0001914)2.58490937
88regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.58387217
89negative regulation of mast cell activation (GO:0033004)2.58127632
90electron transport chain (GO:0022900)2.57513132
91respiratory electron transport chain (GO:0022904)2.56500345
92T cell receptor signaling pathway (GO:0050852)2.55208320
93regulation of T cell apoptotic process (GO:0070232)2.54974391
94negative regulation of viral genome replication (GO:0045071)2.52775744
95response to interferon-beta (GO:0035456)2.52196923
96platelet dense granule organization (GO:0060155)2.51552061
97natural killer cell activation (GO:0030101)2.50742975
98antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.50295870
99deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.50113062
100antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.47016592

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.75879644
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.51756961
3VDR_22108803_ChIP-Seq_LS180_Human3.44532436
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.42061806
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.33537128
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.30556895
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.27426779
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.06717518
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.05673404
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.88452479
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.75452946
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.75360105
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.73730642
14ZNF274_21170338_ChIP-Seq_K562_Hela2.50181911
15VDR_23849224_ChIP-Seq_CD4+_Human2.38927226
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.32746575
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.28336356
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.24310074
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.23899073
20IGF1R_20145208_ChIP-Seq_DFB_Human2.21686445
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18430409
22FOXP3_21729870_ChIP-Seq_TREG_Human2.02379825
23TAF15_26573619_Chip-Seq_HEK293_Human1.97944473
24ELK1_19687146_ChIP-ChIP_HELA_Human1.95815735
25IRF8_21731497_ChIP-ChIP_J774_Mouse1.93477956
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.87335568
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.85023875
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79976200
29MYB_26560356_Chip-Seq_TH2_Human1.77815156
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.76358574
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.71869623
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.70289069
33GATA3_26560356_Chip-Seq_TH2_Human1.70193738
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.66890377
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63230600
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60451541
37STAT4_19710469_ChIP-ChIP_TH1__Mouse1.59422284
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58279417
39EWS_26573619_Chip-Seq_HEK293_Human1.56132578
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.55693221
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.53353700
42RUNX_20019798_ChIP-Seq_JUKART_Human1.47193069
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.44453370
44MYC_18940864_ChIP-ChIP_HL60_Human1.44248932
45RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43825428
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38266407
47ER_23166858_ChIP-Seq_MCF-7_Human1.37087484
48GATA3_27048872_Chip-Seq_THYMUS_Human1.36083709
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30955218
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29640526
51AR_20517297_ChIP-Seq_VCAP_Human1.29087724
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.28461900
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27605772
54TP53_22573176_ChIP-Seq_HFKS_Human1.26808037
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26370870
56PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.25791576
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24143416
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.24143416
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.23339776
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23093595
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19467593
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.19264738
63IRF1_19129219_ChIP-ChIP_H3396_Human1.18407730
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17574364
65NANOG_19829295_ChIP-Seq_ESCs_Human1.16108293
66SOX2_19829295_ChIP-Seq_ESCs_Human1.16108293
67PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13749670
68TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.13641637
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13410447
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13355798
71FUS_26573619_Chip-Seq_HEK293_Human1.11744752
72GBX2_23144817_ChIP-Seq_PC3_Human1.11072917
73HTT_18923047_ChIP-ChIP_STHdh_Human1.10790267
74GATA6_21074721_ChIP-Seq_CACO-2_Human1.08602666
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.08118811
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07862512
77P300_19829295_ChIP-Seq_ESCs_Human1.06578401
78LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06197122
79RBPJ_21746931_ChIP-Seq_IB4_Human1.05908803
80FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05347834
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05006073
82STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.04713486
83GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.02054781
84FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00930768
85PHF8_20622853_ChIP-Seq_HELA_Human0.97135376
86CRX_20693478_ChIP-Seq_RETINA_Mouse0.96517175
87MYB_26560356_Chip-Seq_TH1_Human0.95895782
88CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95640358
89GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95384407
90AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94660212
91RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.94373117
92BCAT_22108803_ChIP-Seq_LS180_Human0.91263592
93GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.91188838
94EGR1_23403033_ChIP-Seq_LIVER_Mouse0.90283550
95CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.89630749
96FOXH1_21741376_ChIP-Seq_EPCs_Human0.88978876
97ETV1_20927104_ChIP-Seq_GIST48_Human0.88066454
98SALL4_22934838_ChIP-ChIP_CD34+_Human0.87464850
99NCOR_22424771_ChIP-Seq_293T_Human0.86421914
100GATA3_26560356_Chip-Seq_TH1_Human0.86013169

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.37198658
2MP0002102_abnormal_ear_morphology3.39389026
3MP0001835_abnormal_antigen_presentation3.15534971
4MP0003763_abnormal_thymus_physiology2.89155871
5MP0009785_altered_susceptibility_to2.68994452
6MP0005000_abnormal_immune_tolerance2.45019523
7MP0002166_altered_tumor_susceptibility2.44486128
8MP0009333_abnormal_splenocyte_physiolog2.39571773
9MP0001873_stomach_inflammation2.37257896
10MP0005360_urolithiasis2.32740973
11MP0001800_abnormal_humoral_immune2.23441157
12MP0000685_abnormal_immune_system2.20026751
13MP0005387_immune_system_phenotype2.16933359
14MP0001790_abnormal_immune_system2.16933359
15MP0000372_irregular_coat_pigmentation2.16391443
16MP0008872_abnormal_physiological_respon2.13101853
17MP0002138_abnormal_hepatobiliary_system2.07379635
18MP0002723_abnormal_immune_serum1.94586344
19MP0002420_abnormal_adaptive_immunity1.93765969
20MP0002148_abnormal_hypersensitivity_rea1.91956119
21MP0006082_CNS_inflammation1.87223072
22MP0003786_premature_aging1.86164647
23MP0001348_abnormal_lacrimal_gland1.85217807
24MP0001819_abnormal_immune_cell1.83660066
25MP0002006_tumorigenesis1.83593098
26MP0005464_abnormal_platelet_physiology1.82392456
27MP0002876_abnormal_thyroid_physiology1.77938862
28MP0002736_abnormal_nociception_after1.73144702
29MP0001986_abnormal_taste_sensitivity1.71044849
30MP0008877_abnormal_DNA_methylation1.70139540
31MP0002452_abnormal_antigen_presenting1.67608295
32MP0002398_abnormal_bone_marrow1.67430602
33MP0003866_abnormal_defecation1.64165612
34MP0006072_abnormal_retinal_apoptosis1.61326718
35MP0008875_abnormal_xenobiotic_pharmacok1.60644194
36MP0000689_abnormal_spleen_morphology1.59286489
37MP0005025_abnormal_response_to1.57454021
38MP0000716_abnormal_immune_system1.51506805
39MP0001968_abnormal_touch/_nociception1.47784653
40MP0001501_abnormal_sleep_pattern1.47295617
41MP0010155_abnormal_intestine_physiology1.42706260
42MP0003646_muscle_fatigue1.40298100
43MP0001845_abnormal_inflammatory_respons1.39880983
44MP0000703_abnormal_thymus_morphology1.39597992
45MP0001905_abnormal_dopamine_level1.38646746
46MP0002722_abnormal_immune_system1.35035232
47MP0005084_abnormal_gallbladder_morpholo1.34434837
48MP0004043_abnormal_pH_regulation1.34397677
49MP0006036_abnormal_mitochondrial_physio1.33836190
50MP0005075_abnormal_melanosome_morpholog1.33492819
51MP0004742_abnormal_vestibular_system1.30395006
52MP0010386_abnormal_urinary_bladder1.27855334
53MP0009697_abnormal_copulation1.27587488
54MP0002638_abnormal_pupillary_reflex1.26569477
55MP0002429_abnormal_blood_cell1.24398631
56MP0001661_extended_life_span1.17804539
57MP0003011_delayed_dark_adaptation1.13160371
58MP0005410_abnormal_fertilization1.11032679
59MP0004142_abnormal_muscle_tone1.10051841
60MP0005645_abnormal_hypothalamus_physiol1.06936093
61MP0005253_abnormal_eye_physiology1.05999219
62MP0003183_abnormal_peptide_metabolism1.05886633
63MP0002933_joint_inflammation1.05454231
64MP0003806_abnormal_nucleotide_metabolis1.04209196
65MP0002405_respiratory_system_inflammati1.03791634
66MP0002163_abnormal_gland_morphology1.03149802
67MP0005551_abnormal_eye_electrophysiolog1.02909215
68MP0004145_abnormal_muscle_electrophysio1.00418102
69MP0005646_abnormal_pituitary_gland1.00388690
70MP0002837_dystrophic_cardiac_calcinosis0.98848607
71MP0006035_abnormal_mitochondrial_morpho0.96147785
72MP0005379_endocrine/exocrine_gland_phen0.94221252
73MP0003880_abnormal_central_pattern0.94043306
74MP0002909_abnormal_adrenal_gland0.91277578
75MP0003252_abnormal_bile_duct0.89883930
76MP0002419_abnormal_innate_immunity0.87954790
77MP0004147_increased_porphyrin_level0.87482536
78MP0008007_abnormal_cellular_replicative0.86781330
79MP0009745_abnormal_behavioral_response0.86743838
80MP0003436_decreased_susceptibility_to0.86729280
81MP0005310_abnormal_salivary_gland0.86597234
82MP0002693_abnormal_pancreas_physiology0.84987717
83MP0002272_abnormal_nervous_system0.84817269
84MP0003448_altered_tumor_morphology0.84260407
85MP0005636_abnormal_mineral_homeostasis0.81815510
86MP0008469_abnormal_protein_level0.80454501
87MP0009763_increased_sensitivity_to0.80211938
88MP0001764_abnormal_homeostasis0.79910780
89MP0001984_abnormal_olfaction0.79358012
90MP0003724_increased_susceptibility_to0.78539862
91MP0002234_abnormal_pharynx_morphology0.78305044
92MP0000465_gastrointestinal_hemorrhage0.77928421
93MP0004084_abnormal_cardiac_muscle0.77070257
94MP0006276_abnormal_autonomic_nervous0.75928828
95MP0001919_abnormal_reproductive_system0.74199696
96MP0000538_abnormal_urinary_bladder0.74163276
97MP0005167_abnormal_blood-brain_barrier0.71746542
98MP0002733_abnormal_thermal_nociception0.71030363
99MP0009764_decreased_sensitivity_to0.69542919
100MP0009046_muscle_twitch0.69226842

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)5.29819319
2T lymphocytopenia (HP:0005403)5.10093739
3Abnormality of T cell number (HP:0011839)5.01934934
4Abnormality of B cell number (HP:0010975)4.47608433
5B lymphocytopenia (HP:0010976)4.40582365
6Severe combined immunodeficiency (HP:0004430)4.30731844
7IgG deficiency (HP:0004315)4.12745953
8Chronic diarrhea (HP:0002028)3.95161916
9Increased IgM level (HP:0003496)3.82173984
10Thyroiditis (HP:0100646)3.75689478
11Renal cortical cysts (HP:0000803)3.63900125
12Abnormality of T cells (HP:0002843)3.59668648
13Acute necrotizing encephalopathy (HP:0006965)3.57540870
14Dyschromatopsia (HP:0007641)3.46287851
15Combined immunodeficiency (HP:0005387)3.37682870
16Autoimmune hemolytic anemia (HP:0001890)3.35906023
17Mitochondrial inheritance (HP:0001427)3.33105308
18Elevated erythrocyte sedimentation rate (HP:0003565)3.30396202
19Increased CSF lactate (HP:0002490)3.20891804
20Acute encephalopathy (HP:0006846)3.14518616
21Hypoproteinemia (HP:0003075)3.12576138
22Abnormal mitochondria in muscle tissue (HP:0008316)3.11980601
23Abnormality of eosinophils (HP:0001879)3.09648534
24Hepatic necrosis (HP:0002605)3.07475978
25Abnormality of the prostate (HP:0008775)3.01984333
26Hepatocellular necrosis (HP:0001404)2.98271323
27Progressive macrocephaly (HP:0004481)2.94281567
28Abnormality of the renal cortex (HP:0011035)2.84118061
29Generalized aminoaciduria (HP:0002909)2.76404042
30Abolished electroretinogram (ERG) (HP:0000550)2.73234009
31Joint swelling (HP:0001386)2.71375473
32Pancytopenia (HP:0001876)2.66539501
33Increased hepatocellular lipid droplets (HP:0006565)2.65912640
343-Methylglutaconic aciduria (HP:0003535)2.65655476
35Increased serum lactate (HP:0002151)2.60166001
36Lipid accumulation in hepatocytes (HP:0006561)2.58030577
37Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.56743362
38Abnormality of alanine metabolism (HP:0010916)2.56743362
39Hyperalaninemia (HP:0003348)2.56743362
40Stomatitis (HP:0010280)2.50782177
41Hypomagnesemia (HP:0002917)2.47748872
42Pancreatic cysts (HP:0001737)2.46359755
43Eosinophilia (HP:0001880)2.42552881
44Optic disc pallor (HP:0000543)2.38369473
45Abnormality of T cell physiology (HP:0011840)2.38197586
46Renal Fanconi syndrome (HP:0001994)2.31476675
47Cerebral edema (HP:0002181)2.29303485
48Abnormality of midbrain morphology (HP:0002418)2.26933843
49Molar tooth sign on MRI (HP:0002419)2.26933843
50Aplasia/hypoplasia of the uterus (HP:0008684)2.26387188
51Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.23221408
52Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.21218991
53Increased intramyocellular lipid droplets (HP:0012240)2.20980129
54Encephalitis (HP:0002383)2.20933781
55Prostate neoplasm (HP:0100787)2.20007171
56Congenital, generalized hypertrichosis (HP:0004540)2.18495179
57Hypothermia (HP:0002045)2.17441971
58Tongue fasciculations (HP:0001308)2.16022650
59Abnormality of magnesium homeostasis (HP:0004921)2.14985372
60Lactic acidosis (HP:0003128)2.14527268
61Leukocytosis (HP:0001974)2.13452928
62Chronic mucocutaneous candidiasis (HP:0002728)2.09746744
63Recurrent cutaneous fungal infections (HP:0011370)2.09746744
64Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.09593042
65Decreased activity of mitochondrial respiratory chain (HP:0008972)2.09593042
66Abnormal delayed hypersensitivity skin test (HP:0002963)2.09536821
67Exertional dyspnea (HP:0002875)2.07300201
68Retrobulbar optic neuritis (HP:0100654)2.06189686
69Optic neuritis (HP:0100653)2.06189686
70Absent rod-and cone-mediated responses on ERG (HP:0007688)2.04922098
71Autoimmune thrombocytopenia (HP:0001973)2.04810068
72Congenital stationary night blindness (HP:0007642)2.01850279
73Lymphoma (HP:0002665)2.00062602
74Petechiae (HP:0000967)1.99023145
75Decreased electroretinogram (ERG) amplitude (HP:0000654)1.98242185
76Pulmonary infiltrates (HP:0002113)1.97606503
77True hermaphroditism (HP:0010459)1.96065844
78Pancreatic fibrosis (HP:0100732)1.95278388
79Delayed CNS myelination (HP:0002188)1.94572483
80Hypoplasia of the thymus (HP:0000778)1.94522615
81Recurrent bronchitis (HP:0002837)1.92668199
82Abnormal drinking behavior (HP:0030082)1.92367495
83Polydipsia (HP:0001959)1.92367495
84Hypoplasia of the uterus (HP:0000013)1.91830500
85Methylmalonic acidemia (HP:0002912)1.86641986
86Recurrent fungal infections (HP:0002841)1.86516349
87Myositis (HP:0100614)1.84841335
88Increased muscle lipid content (HP:0009058)1.82918191
89Oral leukoplakia (HP:0002745)1.82117992
90Lethargy (HP:0001254)1.82111923
91IgM deficiency (HP:0002850)1.81590660
92Neutropenia (HP:0001875)1.80861147
93Constricted visual fields (HP:0001133)1.76016040
94Keratoconjunctivitis (HP:0001096)1.75462396
95Polyuria (HP:0000103)1.73610505
96Respiratory failure (HP:0002878)1.71449515
97Exercise intolerance (HP:0003546)1.71394263
98Keratoconjunctivitis sicca (HP:0001097)1.69554279
99Leukodystrophy (HP:0002415)1.69345953
100Muscle fibrillation (HP:0010546)1.69222831

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.88331085
2KDR3.21413593
3MAP3K123.13719310
4TRIM283.02270832
5SIK32.95470530
6BCR2.82229657
7TESK22.64312890
8EIF2AK12.48548638
9EIF2AK32.46477819
10SCYL22.31564366
11ADRBK22.26458070
12VRK22.17518625
13ZAK2.17267147
14MST42.16953359
15MAP4K11.95127986
16TESK11.78043727
17MYLK1.77730637
18ITK1.75268800
19TLK11.71940518
20TEC1.63618235
21VRK11.62087254
22LIMK11.57680830
23GRK11.52858804
24BCKDK1.45510072
25FES1.41968991
26ERBB31.40928191
27NUAK11.37616290
28DAPK11.36675081
29BMPR1B1.34595895
30TSSK61.23827014
31RPS6KA41.23362775
32SRPK11.20972869
33TAOK31.13761249
34SYK1.06907605
35FRK1.04309707
36MAPK131.02437763
37PINK11.02117621
38WNK31.00144835
39CSNK1G30.99672115
40BTK0.95483834
41ACVR1B0.93934970
42WNK40.89336449
43STK160.84778110
44CSNK1G10.84169560
45PRKCQ0.83360066
46MAP2K60.82209847
47MAPKAPK30.80770606
48EIF2AK20.80052819
49IKBKE0.78369106
50CSNK1G20.77396585
51NEK10.77247025
52ZAP700.77167741
53PLK20.76620008
54GRK50.72465436
55KIT0.72325948
56LCK0.70345377
57PLK30.70272632
58LYN0.69600782
59GRK70.68055851
60TAF10.66854600
61IKBKB0.65669410
62CDK80.64987510
63CSNK1A1L0.59482724
64BUB10.57342594
65TNK20.56200074
66FLT30.55981338
67MAP2K70.52590349
68MAP3K110.51492570
69MAP4K20.50896657
70DAPK30.50839385
71RPS6KA50.50652720
72TIE10.50170722
73DYRK20.49548745
74INSRR0.49416589
75PRKCE0.49209696
76PIK3CA0.47053479
77PAK30.44700498
78TGFBR10.43804314
79GRK60.43199806
80IGF1R0.42944057
81CAMKK20.42441910
82CDC70.42062758
83PASK0.41573095
84PHKG10.40242211
85PHKG20.40242211
86ADRBK10.38135759
87CSK0.37911799
88MARK30.37708896
89CSF1R0.37420292
90HCK0.36683603
91PIK3CG0.36394877
92PDK20.33963322
93CAMK2A0.33776911
94PRKCA0.33200481
95CSNK1A10.31840939
96TBK10.31681796
97JAK30.31445670
98PRKACA0.29633844
99NME10.29188442
100MINK10.28580747

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.25008650
2Primary immunodeficiency_Homo sapiens_hsa053404.10707315
3Oxidative phosphorylation_Homo sapiens_hsa001903.05999797
4Protein export_Homo sapiens_hsa030603.05782429
5Parkinsons disease_Homo sapiens_hsa050122.82613024
6Autoimmune thyroid disease_Homo sapiens_hsa053202.70578899
7Allograft rejection_Homo sapiens_hsa053302.67822673
8Graft-versus-host disease_Homo sapiens_hsa053322.45277338
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.26908079
10Hematopoietic cell lineage_Homo sapiens_hsa046402.24259064
11Antigen processing and presentation_Homo sapiens_hsa046122.16588684
12RNA polymerase_Homo sapiens_hsa030202.00063179
13Type I diabetes mellitus_Homo sapiens_hsa049401.98693429
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.92356803
15Asthma_Homo sapiens_hsa053101.85917706
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.82944853
17T cell receptor signaling pathway_Homo sapiens_hsa046601.56323554
18Huntingtons disease_Homo sapiens_hsa050161.52560323
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.50744294
20Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.48084266
21Sulfur metabolism_Homo sapiens_hsa009201.47950311
22Non-homologous end-joining_Homo sapiens_hsa034501.45280245
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.44967897
24Alzheimers disease_Homo sapiens_hsa050101.44935996
25Rheumatoid arthritis_Homo sapiens_hsa053231.42528754
26Mismatch repair_Homo sapiens_hsa034301.36386498
27Collecting duct acid secretion_Homo sapiens_hsa049661.34627145
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.33165445
29Phototransduction_Homo sapiens_hsa047441.30285221
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26857654
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21337822
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20464183
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.16566230
34Pyrimidine metabolism_Homo sapiens_hsa002401.14805889
35Nitrogen metabolism_Homo sapiens_hsa009101.12196829
36RNA degradation_Homo sapiens_hsa030181.01212530
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99828828
38One carbon pool by folate_Homo sapiens_hsa006700.99443217
39Caffeine metabolism_Homo sapiens_hsa002320.98685609
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98056094
41Homologous recombination_Homo sapiens_hsa034400.96030898
42Measles_Homo sapiens_hsa051620.94323123
43Linoleic acid metabolism_Homo sapiens_hsa005910.94286234
44Cardiac muscle contraction_Homo sapiens_hsa042600.92794121
45Purine metabolism_Homo sapiens_hsa002300.91503901
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88231669
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85571276
48Fatty acid elongation_Homo sapiens_hsa000620.83163410
49Butanoate metabolism_Homo sapiens_hsa006500.82012771
50Basal transcription factors_Homo sapiens_hsa030220.80161259
51Folate biosynthesis_Homo sapiens_hsa007900.79100357
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76218761
53Retinol metabolism_Homo sapiens_hsa008300.75921570
54Systemic lupus erythematosus_Homo sapiens_hsa053220.75545521
55Viral myocarditis_Homo sapiens_hsa054160.74275455
56Propanoate metabolism_Homo sapiens_hsa006400.74108956
57Peroxisome_Homo sapiens_hsa041460.72682828
58Legionellosis_Homo sapiens_hsa051340.71998200
59Salmonella infection_Homo sapiens_hsa051320.70002907
60Fanconi anemia pathway_Homo sapiens_hsa034600.68346260
61RNA transport_Homo sapiens_hsa030130.62911040
62Spliceosome_Homo sapiens_hsa030400.61145583
63Tryptophan metabolism_Homo sapiens_hsa003800.60889441
64Shigellosis_Homo sapiens_hsa051310.58833922
65DNA replication_Homo sapiens_hsa030300.58777031
66Chemical carcinogenesis_Homo sapiens_hsa052040.58425360
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.57562955
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57369704
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57317356
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55609361
71Herpes simplex infection_Homo sapiens_hsa051680.55189208
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52655010
73Olfactory transduction_Homo sapiens_hsa047400.51578492
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.49172099
75Ether lipid metabolism_Homo sapiens_hsa005650.48938630
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48632936
77Epstein-Barr virus infection_Homo sapiens_hsa051690.47425529
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.47164228
79Regulation of autophagy_Homo sapiens_hsa041400.46876852
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46833381
81Nucleotide excision repair_Homo sapiens_hsa034200.46643522
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45805067
83Metabolic pathways_Homo sapiens_hsa011000.43787405
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42900394
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40895873
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40599278
87Pyruvate metabolism_Homo sapiens_hsa006200.40399041
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39537621
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.39349624
90Base excision repair_Homo sapiens_hsa034100.39169885
91Arachidonic acid metabolism_Homo sapiens_hsa005900.35977882
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30325086
93Alcoholism_Homo sapiens_hsa050340.23965458
94beta-Alanine metabolism_Homo sapiens_hsa004100.23225351
95Serotonergic synapse_Homo sapiens_hsa047260.22583984
96Synaptic vesicle cycle_Homo sapiens_hsa047210.21717456
97Morphine addiction_Homo sapiens_hsa050320.21657209
98Taste transduction_Homo sapiens_hsa047420.21134954
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.20896126
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20434041

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