YWHAZP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)9.37820934
2protein-cofactor linkage (GO:0018065)5.57416826
3mitochondrial DNA replication (GO:0006264)5.22125122
4fatty acid elongation (GO:0030497)4.76322634
5DNA deamination (GO:0045006)4.53302539
6DNA catabolic process, exonucleolytic (GO:0000738)4.36639626
7adenosine metabolic process (GO:0046085)4.36584973
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.28843752
9cornea development in camera-type eye (GO:0061303)4.17903507
10translesion synthesis (GO:0019985)4.17580039
11postreplication repair (GO:0006301)4.11307767
12atrial cardiac muscle cell action potential (GO:0086014)4.04955337
13meiotic chromosome segregation (GO:0045132)3.90082807
14somite development (GO:0061053)3.73874788
15regulation of nuclear cell cycle DNA replication (GO:0033262)3.73668404
16negative regulation of transcription regulatory region DNA binding (GO:2000678)3.67870096
17regulation of DNA endoreduplication (GO:0032875)3.63909376
18neuron fate determination (GO:0048664)3.57410035
19mannosylation (GO:0097502)3.54954962
20respiratory chain complex IV assembly (GO:0008535)3.48079033
21regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.38448086
22DNA replication checkpoint (GO:0000076)3.35987095
23Arp2/3 complex-mediated actin nucleation (GO:0034314)3.30207475
24cerebral cortex radially oriented cell migration (GO:0021799)3.25611580
25microtubule depolymerization (GO:0007019)3.16243567
26actin nucleation (GO:0045010)3.07455441
27spliceosomal complex assembly (GO:0000245)3.05852874
28DNA-dependent DNA replication (GO:0006261)3.05770939
29establishment of protein localization to mitochondrial membrane (GO:0090151)2.98529286
30cytochrome complex assembly (GO:0017004)2.95560324
31nucleotide transmembrane transport (GO:1901679)2.90151152
32positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.89316579
33negative regulation of telomere maintenance (GO:0032205)2.87524062
34protein complex biogenesis (GO:0070271)2.85695699
35kynurenine metabolic process (GO:0070189)2.83911611
36L-fucose catabolic process (GO:0042355)2.81964392
37fucose catabolic process (GO:0019317)2.81964392
38L-fucose metabolic process (GO:0042354)2.81964392
39adaptation of signaling pathway (GO:0023058)2.81431957
40telomere maintenance via semi-conservative replication (GO:0032201)2.78588742
41detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.77832975
42cytidine deamination (GO:0009972)2.76413451
43cytidine metabolic process (GO:0046087)2.76413451
44cytidine catabolic process (GO:0006216)2.76413451
45positive regulation of DNA-dependent DNA replication (GO:2000105)2.75943647
46indolalkylamine metabolic process (GO:0006586)2.74237326
47telomere maintenance via recombination (GO:0000722)2.72743233
48regulation of rhodopsin mediated signaling pathway (GO:0022400)2.69821591
49mitochondrial respiratory chain complex assembly (GO:0033108)2.69662568
50histamine secretion (GO:0001821)2.67050715
51regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.65988763
52replication fork processing (GO:0031297)2.65760259
53developmental pigmentation (GO:0048066)2.64405792
54rhodopsin mediated signaling pathway (GO:0016056)2.62174808
55platelet dense granule organization (GO:0060155)2.61961506
56mismatch repair (GO:0006298)2.61799054
57positive regulation of calcium-mediated signaling (GO:0050850)2.61260881
58positive regulation of triglyceride biosynthetic process (GO:0010867)2.60885589
59histone mRNA metabolic process (GO:0008334)2.59776269
60transepithelial transport (GO:0070633)2.59458940
61pyrimidine ribonucleoside catabolic process (GO:0046133)2.59192073
62negative regulation of DNA binding (GO:0043392)2.56480662
63mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.55733931
64recombinational repair (GO:0000725)2.55294494
65double-strand break repair via homologous recombination (GO:0000724)2.55129409
66mitotic recombination (GO:0006312)2.52727696
67detection of light stimulus involved in sensory perception (GO:0050962)2.52612689
68detection of light stimulus involved in visual perception (GO:0050908)2.52612689
69sequestering of actin monomers (GO:0042989)2.51270198
70protein deneddylation (GO:0000338)2.50534217
71mitochondrial respiratory chain complex I assembly (GO:0032981)2.50361432
72NADH dehydrogenase complex assembly (GO:0010257)2.50361432
73mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.50361432
74mitochondrial DNA metabolic process (GO:0032042)2.50230413
75regulation of hypersensitivity (GO:0002883)2.49693108
76vascular smooth muscle contraction (GO:0014829)2.49077477
77rRNA modification (GO:0000154)2.49019060
78DNA replication-dependent nucleosome assembly (GO:0006335)2.47239685
79DNA replication-dependent nucleosome organization (GO:0034723)2.47239685
80chaperone-mediated protein transport (GO:0072321)2.46963106
81rRNA methylation (GO:0031167)2.45083148
82dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.44801204
83cullin deneddylation (GO:0010388)2.43050306
84behavioral response to nicotine (GO:0035095)2.42962090
85negative regulation of calcium ion transport into cytosol (GO:0010523)2.39350905
86somatic hypermutation of immunoglobulin genes (GO:0016446)2.38624616
87somatic diversification of immune receptors via somatic mutation (GO:0002566)2.38624616
88regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.37052796
89proteasome assembly (GO:0043248)2.36159717
90regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.33174970
91protein neddylation (GO:0045116)2.33084295
92cellular ketone body metabolic process (GO:0046950)2.32508068
93positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.32040402
94regulation of sister chromatid cohesion (GO:0007063)2.31913840
95regulation of cellular amino acid metabolic process (GO:0006521)2.31497823
96protein K11-linked deubiquitination (GO:0035871)2.31223794
97regulation of acyl-CoA biosynthetic process (GO:0050812)2.28709419
98positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.28461445
99regulation of T cell receptor signaling pathway (GO:0050856)2.26544061
100aggressive behavior (GO:0002118)2.26496561

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.86848846
2E2F7_22180533_ChIP-Seq_HELA_Human3.52570150
3EZH2_22144423_ChIP-Seq_EOC_Human3.29188268
4VDR_22108803_ChIP-Seq_LS180_Human3.25448380
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.16439346
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.97227640
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.90968314
8ZNF274_21170338_ChIP-Seq_K562_Hela2.90711080
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.70300850
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.63420163
11TAF15_26573619_Chip-Seq_HEK293_Human2.60516939
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.44304942
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.28521323
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.27707598
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.17007570
16EWS_26573619_Chip-Seq_HEK293_Human2.12102197
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.06185027
18IGF1R_20145208_ChIP-Seq_DFB_Human2.05341671
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.01154978
20ELK1_19687146_ChIP-ChIP_HELA_Human1.99989044
21P300_19829295_ChIP-Seq_ESCs_Human1.98905155
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.98692164
23GBX2_23144817_ChIP-Seq_PC3_Human1.88183310
24FUS_26573619_Chip-Seq_HEK293_Human1.87344675
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86076361
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.81602662
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80114995
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.68835427
29MYC_18940864_ChIP-ChIP_HL60_Human1.68680299
30NFE2_27457419_Chip-Seq_LIVER_Mouse1.68666076
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64638082
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62977050
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60595488
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60017360
35SUZ12_27294783_Chip-Seq_NPCs_Mouse1.57286221
36EZH2_27294783_Chip-Seq_NPCs_Mouse1.57200910
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50997259
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49739501
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49077922
40TP53_22573176_ChIP-Seq_HFKS_Human1.48168273
41VDR_23849224_ChIP-Seq_CD4+_Human1.47043862
42ER_23166858_ChIP-Seq_MCF-7_Human1.46050431
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44034318
44BCAT_22108803_ChIP-Seq_LS180_Human1.42593363
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40604235
46CBP_20019798_ChIP-Seq_JUKART_Human1.40604235
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.39411428
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34138972
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31326230
50NANOG_18555785_Chip-Seq_ESCs_Mouse1.29929316
51CRX_20693478_ChIP-Seq_RETINA_Mouse1.28294263
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27447955
53P53_22387025_ChIP-Seq_ESCs_Mouse1.26084000
54STAT3_18555785_Chip-Seq_ESCs_Mouse1.24941925
55IRF1_19129219_ChIP-ChIP_H3396_Human1.23167472
56EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23108750
57NANOG_19829295_ChIP-Seq_ESCs_Human1.21486838
58SOX2_19829295_ChIP-Seq_ESCs_Human1.21486838
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20708376
60E2F4_17652178_ChIP-ChIP_JURKAT_Human1.20496969
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20475203
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20097117
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19516353
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18576702
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18142655
66SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.17894745
67HTT_18923047_ChIP-ChIP_STHdh_Human1.17515678
68SMAD4_21799915_ChIP-Seq_A2780_Human1.16838530
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16030865
70P300_18555785_Chip-Seq_ESCs_Mouse1.15747403
71EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15332896
72AR_25329375_ChIP-Seq_VCAP_Human1.15135641
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14211810
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.12433470
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12054292
76SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10896086
77KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09602763
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.09388036
79SOX2_18555785_Chip-Seq_ESCs_Mouse1.09163835
80CMYC_18555785_Chip-Seq_ESCs_Mouse1.07532543
81OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06658673
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06323284
83TCF4_23295773_ChIP-Seq_U87_Human1.05772551
84PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.03762247
85AR_20517297_ChIP-Seq_VCAP_Human1.03405630
86TCF4_22108803_ChIP-Seq_LS180_Human1.02770723
87STAT3_23295773_ChIP-Seq_U87_Human1.02686939
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02156655
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02156655
90E2F1_18555785_Chip-Seq_ESCs_Mouse1.00432639
91RBPJ_21746931_ChIP-Seq_IB4_Human0.99134165
92FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98449246
93NCOR_22424771_ChIP-Seq_293T_Human0.97348825
94NMYC_18555785_Chip-Seq_ESCs_Mouse0.97151349
95ETV1_20927104_ChIP-Seq_GIST48_Human0.96935053
96PRDM14_20953172_ChIP-Seq_ESCs_Human0.96442535
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95537858
98SRF_21415370_ChIP-Seq_HL-1_Mouse0.95429358
99FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95359218
100FOXA1_25329375_ChIP-Seq_VCAP_Human0.95359218

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.77118716
2MP0008057_abnormal_DNA_replication3.58438948
3MP0006072_abnormal_retinal_apoptosis2.99580950
4MP0008877_abnormal_DNA_methylation2.84258114
5MP0000569_abnormal_digit_pigmentation2.70252245
6MP0003787_abnormal_imprinting2.57850298
7MP0005083_abnormal_biliary_tract2.40639467
8MP0004147_increased_porphyrin_level2.40007690
9MP0002234_abnormal_pharynx_morphology2.39107559
10MP0000372_irregular_coat_pigmentation2.28287943
11MP0005671_abnormal_response_to2.27490930
12MP0002163_abnormal_gland_morphology2.24781108
13MP0003137_abnormal_impulse_conducting2.18201190
14MP0002102_abnormal_ear_morphology2.04528108
15MP0003195_calcinosis1.99490849
16MP0005367_renal/urinary_system_phenotyp1.90706301
17MP0000516_abnormal_urinary_system1.90706301
18MP0010094_abnormal_chromosome_stability1.90026663
19MP0002006_tumorigenesis1.89612528
20MP0002653_abnormal_ependyma_morphology1.86384596
21MP0008872_abnormal_physiological_respon1.85507079
22MP0005379_endocrine/exocrine_gland_phen1.83482018
23MP0005551_abnormal_eye_electrophysiolog1.82194679
24MP0002166_altered_tumor_susceptibility1.79196910
25MP0008058_abnormal_DNA_repair1.78358460
26MP0008875_abnormal_xenobiotic_pharmacok1.64120409
27MP0005253_abnormal_eye_physiology1.59892232
28MP0004134_abnormal_chest_morphology1.55442910
29MP0002009_preneoplasia1.52460742
30MP0004142_abnormal_muscle_tone1.48336158
31MP0003121_genomic_imprinting1.42830843
32MP0000015_abnormal_ear_pigmentation1.38812494
33MP0009046_muscle_twitch1.37850494
34MP0008789_abnormal_olfactory_epithelium1.35784008
35MP0002751_abnormal_autonomic_nervous1.35709707
36MP0000631_abnormal_neuroendocrine_gland1.34442225
37MP0003786_premature_aging1.34375927
38MP0003718_maternal_effect1.26529755
39MP0002733_abnormal_thermal_nociception1.23063821
40MP0004215_abnormal_myocardial_fiber1.19321897
41MP0003880_abnormal_central_pattern1.14072317
42MP0005084_abnormal_gallbladder_morpholo1.11132046
43MP0000778_abnormal_nervous_system1.11045538
44MP0004145_abnormal_muscle_electrophysio1.10644423
45MP0005646_abnormal_pituitary_gland1.10135113
46MP0002837_dystrophic_cardiac_calcinosis1.08375239
47MP0000049_abnormal_middle_ear1.07609314
48MP0005174_abnormal_tail_pigmentation1.06823003
49MP0005248_abnormal_Harderian_gland1.04653950
50MP0009745_abnormal_behavioral_response1.01920940
51MP0005645_abnormal_hypothalamus_physiol1.01651445
52MP0003186_abnormal_redox_activity1.00418861
53MP0003806_abnormal_nucleotide_metabolis0.99735899
54MP0001764_abnormal_homeostasis0.99414359
55MP0001919_abnormal_reproductive_system0.97671263
56MP0005171_absent_coat_pigmentation0.96827847
57MP0005395_other_phenotype0.96717590
58MP0003646_muscle_fatigue0.96500869
59MP0002168_other_aberrant_phenotype0.95951063
60MP0002735_abnormal_chemical_nociception0.95831984
61MP0000427_abnormal_hair_cycle0.95691368
62MP0005408_hypopigmentation0.95658496
63MP0001970_abnormal_pain_threshold0.94595867
64MP0006276_abnormal_autonomic_nervous0.93664406
65MP0001346_abnormal_lacrimal_gland0.92773221
66MP0002272_abnormal_nervous_system0.89592874
67MP0002938_white_spotting0.89127963
68MP0009697_abnormal_copulation0.87136083
69MP0005389_reproductive_system_phenotype0.86255797
70MP0001968_abnormal_touch/_nociception0.85984565
71MP0001986_abnormal_taste_sensitivity0.83387775
72MP0004924_abnormal_behavior0.82822086
73MP0005386_behavior/neurological_phenoty0.82822086
74MP0001835_abnormal_antigen_presentation0.82582328
75MP0001119_abnormal_female_reproductive0.82490079
76MP0003567_abnormal_fetal_cardiomyocyte0.81383969
77MP0000465_gastrointestinal_hemorrhage0.81050996
78MP0006035_abnormal_mitochondrial_morpho0.80275305
79MP0001929_abnormal_gametogenesis0.80269282
80MP0005499_abnormal_olfactory_system0.79474281
81MP0005394_taste/olfaction_phenotype0.79474281
82MP0005075_abnormal_melanosome_morpholog0.78873303
83MP0003938_abnormal_ear_development0.78124010
84MP0003221_abnormal_cardiomyocyte_apopto0.76458538
85MP0003122_maternal_imprinting0.76409622
86MP0002090_abnormal_vision0.74074792
87MP0000371_diluted_coat_color0.74029187
88MP0003693_abnormal_embryo_hatching0.73508612
89MP0002184_abnormal_innervation0.71826844
90MP0003878_abnormal_ear_physiology0.71506881
91MP0005377_hearing/vestibular/ear_phenot0.71506881
92MP0009250_abnormal_appendicular_skeleto0.70778339
93MP0003656_abnormal_erythrocyte_physiolo0.70102471
94MP0006036_abnormal_mitochondrial_physio0.69812459
95MP0004085_abnormal_heartbeat0.69702692
96MP0004742_abnormal_vestibular_system0.69497718
97MP0001486_abnormal_startle_reflex0.69364775
98MP0005195_abnormal_posterior_eye0.68227804
99MP0003011_delayed_dark_adaptation0.66992281
100MP0003045_fibrosis0.66539139

Predicted human phenotypes

RankGene SetZ-score
1Ectopic kidney (HP:0000086)4.39352647
2Abnormality of B cell number (HP:0010975)3.62853812
3Thyroiditis (HP:0100646)3.55655119
4B lymphocytopenia (HP:0010976)3.54219910
5Exertional dyspnea (HP:0002875)3.50101642
6Hypoproteinemia (HP:0003075)3.48928632
7Pancreatic fibrosis (HP:0100732)3.46907670
8Microglossia (HP:0000171)3.39256217
9Hypothermia (HP:0002045)3.38946471
10Slender build (HP:0001533)3.22414429
113-Methylglutaconic aciduria (HP:0003535)3.19704535
12Severe combined immunodeficiency (HP:0004430)3.15085034
13Pancreatic cysts (HP:0001737)3.04348579
14Aplasia/Hypoplasia of the tibia (HP:0005772)3.01586592
15Short tibia (HP:0005736)2.75616513
16Hepatocellular necrosis (HP:0001404)2.66721703
17Aplasia/Hypoplasia of the tongue (HP:0010295)2.62456153
18Pendular nystagmus (HP:0012043)2.50190132
19Hypoplasia of the thymus (HP:0000778)2.48251128
20Pachygyria (HP:0001302)2.47930025
21Hepatic necrosis (HP:0002605)2.45562694
22Neuroendocrine neoplasm (HP:0100634)2.42852430
23Nephronophthisis (HP:0000090)2.40775799
24Spinal muscular atrophy (HP:0007269)2.39846463
25Combined immunodeficiency (HP:0005387)2.39435384
26Panhypogammaglobulinemia (HP:0003139)2.30210749
27True hermaphroditism (HP:0010459)2.29252808
28Mitochondrial inheritance (HP:0001427)2.28907754
29Abnormality of the ileum (HP:0001549)2.28503660
30Abolished electroretinogram (ERG) (HP:0000550)2.26231979
31Meckel diverticulum (HP:0002245)2.24562312
32Molar tooth sign on MRI (HP:0002419)2.23753948
33Abnormality of midbrain morphology (HP:0002418)2.23753948
34IgG deficiency (HP:0004315)2.23435112
35Abnormality of lateral ventricle (HP:0030047)2.21107500
36Colon cancer (HP:0003003)2.19569629
37Type II lissencephaly (HP:0007260)2.18701330
38Congenital stationary night blindness (HP:0007642)2.17193029
39Dyskinesia (HP:0100660)2.16987518
40Volvulus (HP:0002580)2.16454182
41Erythroderma (HP:0001019)2.14262686
42Hypoalbuminemia (HP:0003073)2.11783270
43Abnormal albumin level (HP:0012116)2.11783270
44Increased serum lactate (HP:0002151)2.10752664
45Abnormality of the renal cortex (HP:0011035)2.10552209
46Increased IgM level (HP:0003496)2.09656175
47Abnormality of the metopic suture (HP:0005556)2.08654355
48Bony spicule pigmentary retinopathy (HP:0007737)2.07638085
49Aplasia/Hypoplasia of the uvula (HP:0010293)2.07213622
50Attenuation of retinal blood vessels (HP:0007843)2.05885003
51Absent rod-and cone-mediated responses on ERG (HP:0007688)2.05675077
52Abnormality of the renal medulla (HP:0100957)2.04018565
53Prominent metopic ridge (HP:0005487)2.03287020
54Increased CSF lactate (HP:0002490)2.03206053
55Drooling (HP:0002307)2.01917763
56Stomatitis (HP:0010280)1.96685677
57Hematochezia (HP:0002573)1.94594843
58Atonic seizures (HP:0010819)1.94446931
59Progressive microcephaly (HP:0000253)1.94185092
60Absent speech (HP:0001344)1.94103989
61Thyroid-stimulating hormone excess (HP:0002925)1.94079726
62Eosinophilia (HP:0001880)1.91271910
63Palpebral edema (HP:0100540)1.89508250
64Cerebellar dysplasia (HP:0007033)1.88398462
65Decreased activity of mitochondrial respiratory chain (HP:0008972)1.87304893
66Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.87304893
67Pheochromocytoma (HP:0002666)1.86078179
68Postaxial foot polydactyly (HP:0001830)1.85412071
69Progressive macrocephaly (HP:0004481)1.83857853
70Excessive salivation (HP:0003781)1.83742196
71Tented upper lip vermilion (HP:0010804)1.83660712
72Abnormality of chromosome stability (HP:0003220)1.83154956
73Metaphyseal dysplasia (HP:0100255)1.82927863
74Hypomagnesemia (HP:0002917)1.82870191
75Broad-based gait (HP:0002136)1.82433304
76Retinal dysplasia (HP:0007973)1.81147500
77Long nose (HP:0003189)1.79922984
78Neoplasm of the adrenal gland (HP:0100631)1.79093627
79Abnormality of eosinophils (HP:0001879)1.78552468
80Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.77913700
81Clubbing of toes (HP:0100760)1.75597027
82Ependymoma (HP:0002888)1.75384832
83Acute necrotizing encephalopathy (HP:0006965)1.75198716
84Constricted visual fields (HP:0001133)1.74231051
85Renal cortical cysts (HP:0000803)1.73509608
86Median cleft lip (HP:0000161)1.73141622
87Neoplasm of the peripheral nervous system (HP:0100007)1.73116582
88Hypoplasia of the pons (HP:0012110)1.72259385
89Type 2 muscle fiber atrophy (HP:0003554)1.70535237
90Abnormal rod and cone electroretinograms (HP:0008323)1.69736163
91Lactic acidosis (HP:0003128)1.68793522
92Albinism (HP:0001022)1.67533858
93Conjunctival hamartoma (HP:0100780)1.66558912
94Failure to thrive in infancy (HP:0001531)1.66305630
95Optic nerve hypoplasia (HP:0000609)1.64579985
96Inability to walk (HP:0002540)1.64424220
97Short 4th metacarpal (HP:0010044)1.63228416
98Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.63228416
99Obstructive sleep apnea (HP:0002870)1.62963055
100Lissencephaly (HP:0001339)1.62526786

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.93936724
2TRIM283.63870832
3ERBB33.27125168
4TXK2.61567513
5ZAK2.43450346
6NUAK12.39445085
7MAP3K122.27657245
8EIF2AK12.23782784
9RPS6KA42.22279027
10MAP4K22.18466700
11TNIK2.11870346
12SIK31.89978315
13BMPR1B1.80815264
14BCR1.79576875
15WNK31.66178618
16MST41.62755570
17VRK21.61109825
18BCKDK1.60639546
19ADRBK21.53432752
20KDR1.52172462
21TLK11.51183411
22EIF2AK31.50571306
23MAPK131.47586842
24EPHA41.46242157
25VRK11.45276513
26SRPK11.42459825
27NTRK31.40652342
28MINK11.35840667
29MUSK1.30705135
30PLK21.28421097
31MYLK1.20857469
32CCNB11.14927613
33TAOK31.13952783
34WEE11.13429235
35PINK11.12034464
36PLK31.09403288
37GRK11.06339195
38CSNK1G21.02445259
39DYRK31.00271818
40CSNK1G30.99184685
41CSNK1G10.98883189
42PAK30.95404492
43STK390.93055383
44WNK40.90482432
45PRKCE0.90053014
46MAP3K40.88884784
47ATR0.86082457
48MAP2K70.82006747
49GRK50.81538859
50NLK0.81243384
51KSR10.81099282
52BRSK20.80339279
53MAP3K20.80210532
54CSNK1A10.79681532
55GRK70.79044434
56CDK30.76396699
57STK38L0.73463784
58PKN10.72860429
59PIK3CA0.71075013
60DYRK20.70328800
61TESK20.70109567
62DAPK10.67305774
63PLK40.66794213
64STK160.66329363
65CSNK1A1L0.65929931
66TEC0.65180800
67BUB10.63996309
68CLK10.61817361
69GRK60.61596523
70CASK0.60548920
71LIMK10.60464431
72INSRR0.59448328
73TSSK60.59242407
74EIF2AK20.55643033
75MAPKAPK50.49281414
76MARK10.49208540
77ROCK10.48819752
78PHKG20.45987216
79PHKG10.45987216
80ITK0.45972012
81OXSR10.45437626
82RPS6KA50.44032589
83TAF10.43033778
84NME10.39971392
85NEK10.39941153
86CAMK2A0.39811957
87STK30.39478693
88CAMK2D0.37432645
89IKBKB0.36877118
90CDK90.36586857
91CDK180.36000976
92CDK140.35808262
93BMPR20.35532091
94SGK20.34839617
95CHEK20.34199146
96PRKACA0.34159585
97ATM0.33735142
98RAF10.33397365
99PNCK0.33085184
100PRKG10.31273343

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.76154875
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.01511859
3Non-homologous end-joining_Homo sapiens_hsa034502.74423943
4Fatty acid elongation_Homo sapiens_hsa000622.65177147
5Protein export_Homo sapiens_hsa030602.60588246
6Fanconi anemia pathway_Homo sapiens_hsa034602.44448378
7Oxidative phosphorylation_Homo sapiens_hsa001902.34603147
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.30297646
9Primary immunodeficiency_Homo sapiens_hsa053402.26994844
10DNA replication_Homo sapiens_hsa030302.15790025
11Phototransduction_Homo sapiens_hsa047442.15384783
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.12168496
13Asthma_Homo sapiens_hsa053102.06502723
14Parkinsons disease_Homo sapiens_hsa050121.94182982
15RNA polymerase_Homo sapiens_hsa030201.89422116
16Butanoate metabolism_Homo sapiens_hsa006501.70553305
17Propanoate metabolism_Homo sapiens_hsa006401.68801920
18Steroid biosynthesis_Homo sapiens_hsa001001.58038406
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.55028317
20One carbon pool by folate_Homo sapiens_hsa006701.49162592
21Autoimmune thyroid disease_Homo sapiens_hsa053201.49094513
22Mismatch repair_Homo sapiens_hsa034301.48482326
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41808691
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.41677579
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40562969
26Allograft rejection_Homo sapiens_hsa053301.38519825
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33049639
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.32522849
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.27969045
30Basal transcription factors_Homo sapiens_hsa030221.26554637
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25809437
32Linoleic acid metabolism_Homo sapiens_hsa005911.25465987
33RNA transport_Homo sapiens_hsa030131.22392282
34Alzheimers disease_Homo sapiens_hsa050101.18998065
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18898862
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17587535
37Homologous recombination_Homo sapiens_hsa034401.16274358
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.14734560
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.11314833
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10894592
41Huntingtons disease_Homo sapiens_hsa050161.09026989
42RNA degradation_Homo sapiens_hsa030181.06777303
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05627709
44Peroxisome_Homo sapiens_hsa041460.99967411
45Type I diabetes mellitus_Homo sapiens_hsa049400.99776447
46Pyrimidine metabolism_Homo sapiens_hsa002400.97393004
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90646108
48Graft-versus-host disease_Homo sapiens_hsa053320.90119242
49Tryptophan metabolism_Homo sapiens_hsa003800.89810048
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89548379
51Nitrogen metabolism_Homo sapiens_hsa009100.88839629
52Hematopoietic cell lineage_Homo sapiens_hsa046400.87273049
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.86194513
54Nicotine addiction_Homo sapiens_hsa050330.85646896
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.85216866
56Cardiac muscle contraction_Homo sapiens_hsa042600.82938470
57Oocyte meiosis_Homo sapiens_hsa041140.82429804
58Retinol metabolism_Homo sapiens_hsa008300.81263449
59Olfactory transduction_Homo sapiens_hsa047400.81088219
60Chemical carcinogenesis_Homo sapiens_hsa052040.80882376
61Spliceosome_Homo sapiens_hsa030400.80515272
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78364631
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76945612
64Nucleotide excision repair_Homo sapiens_hsa034200.73541866
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71247618
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.66300299
67Antigen processing and presentation_Homo sapiens_hsa046120.65743582
68Ether lipid metabolism_Homo sapiens_hsa005650.65690981
69Circadian entrainment_Homo sapiens_hsa047130.65446932
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65055823
71Serotonergic synapse_Homo sapiens_hsa047260.64082334
72GABAergic synapse_Homo sapiens_hsa047270.62670575
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62553911
74Fatty acid metabolism_Homo sapiens_hsa012120.59081746
75Taste transduction_Homo sapiens_hsa047420.57734443
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56289587
77mRNA surveillance pathway_Homo sapiens_hsa030150.54878960
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54385667
79Morphine addiction_Homo sapiens_hsa050320.53176462
80Glycerolipid metabolism_Homo sapiens_hsa005610.50743742
81Purine metabolism_Homo sapiens_hsa002300.49683390
82Rheumatoid arthritis_Homo sapiens_hsa053230.48013595
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47222933
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47114458
85Base excision repair_Homo sapiens_hsa034100.46576596
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45414092
87T cell receptor signaling pathway_Homo sapiens_hsa046600.44752660
88Metabolic pathways_Homo sapiens_hsa011000.44390018
89Caffeine metabolism_Homo sapiens_hsa002320.43986568
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43262279
91Ovarian steroidogenesis_Homo sapiens_hsa049130.42211431
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40447784
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38868549
94Renin secretion_Homo sapiens_hsa049240.37755357
95Mineral absorption_Homo sapiens_hsa049780.37624402
96Hedgehog signaling pathway_Homo sapiens_hsa043400.36589996
97Arachidonic acid metabolism_Homo sapiens_hsa005900.35815148
98Shigellosis_Homo sapiens_hsa051310.34702891
99Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.34622442
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.32962890

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