

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 8.25823780 |
| 2 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 7.78605724 |
| 3 | cytidine metabolic process (GO:0046087) | 7.76361863 |
| 4 | cytidine catabolic process (GO:0006216) | 7.76361863 |
| 5 | cytidine deamination (GO:0009972) | 7.76361863 |
| 6 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 6.94394413 |
| 7 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 5.67384753 |
| 8 | actin nucleation (GO:0045010) | 5.05541024 |
| 9 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 4.62745894 |
| 10 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 4.55243903 |
| 11 | cellular response to interleukin-15 (GO:0071350) | 4.43749641 |
| 12 | protein neddylation (GO:0045116) | 4.16649033 |
| 13 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.11109611 |
| 14 | negative regulation of T cell apoptotic process (GO:0070233) | 4.06410005 |
| 15 | regulation of regulatory T cell differentiation (GO:0045589) | 4.02712768 |
| 16 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 4.01869080 |
| 17 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.78613968 |
| 18 | proteasome assembly (GO:0043248) | 3.78049711 |
| 19 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 3.75488713 |
| 20 | regulation of natural killer cell mediated immunity (GO:0002715) | 3.75488713 |
| 21 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 3.73328636 |
| 22 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.69245320 |
| 23 | sequestering of actin monomers (GO:0042989) | 3.66128074 |
| 24 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.66065160 |
| 25 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.66065160 |
| 26 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.65813837 |
| 27 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.64711489 |
| 28 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.64711489 |
| 29 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.64711489 |
| 30 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.64681145 |
| 31 | positive regulation of interleukin-8 secretion (GO:2000484) | 3.63841046 |
| 32 | response to interleukin-15 (GO:0070672) | 3.51993466 |
| 33 | eosinophil chemotaxis (GO:0048245) | 3.50958686 |
| 34 | pyrimidine nucleoside catabolic process (GO:0046135) | 3.49167995 |
| 35 | positive regulation of cell killing (GO:0031343) | 3.47300290 |
| 36 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.47215849 |
| 37 | ATP synthesis coupled proton transport (GO:0015986) | 3.47215849 |
| 38 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.44197402 |
| 39 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.44197402 |
| 40 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.43951799 |
| 41 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.42973697 |
| 42 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.42664648 |
| 43 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.41343984 |
| 44 | positive regulation of calcium-mediated signaling (GO:0050850) | 3.39342290 |
| 45 | response to interferon-beta (GO:0035456) | 3.33766608 |
| 46 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 3.32485441 |
| 47 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.30774114 |
| 48 | negative regulation of ligase activity (GO:0051352) | 3.30774114 |
| 49 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.28982976 |
| 50 | regulation of T cell mediated cytotoxicity (GO:0001914) | 3.27666622 |
| 51 | regulation of cell killing (GO:0031341) | 3.26576094 |
| 52 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 3.22470286 |
| 53 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.22080969 |
| 54 | positive regulation of defense response to virus by host (GO:0002230) | 3.21974185 |
| 55 | negative regulation by host of viral transcription (GO:0043922) | 3.21119707 |
| 56 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.19929114 |
| 57 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.19929114 |
| 58 | regulation of chronic inflammatory response (GO:0002676) | 3.19927136 |
| 59 | eosinophil migration (GO:0072677) | 3.16398701 |
| 60 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.15042967 |
| 61 | regulation of interleukin-8 secretion (GO:2000482) | 3.12789679 |
| 62 | adaptation of signaling pathway (GO:0023058) | 3.09738248 |
| 63 | base-excision repair, AP site formation (GO:0006285) | 3.06936240 |
| 64 | regulation of T cell receptor signaling pathway (GO:0050856) | 3.02773392 |
| 65 | negative regulation of viral genome replication (GO:0045071) | 3.02711302 |
| 66 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 2.98983365 |
| 67 | respiratory electron transport chain (GO:0022904) | 2.97223940 |
| 68 | cellular response to interferon-beta (GO:0035458) | 2.97211314 |
| 69 | electron transport chain (GO:0022900) | 2.96268404 |
| 70 | cytolysis (GO:0019835) | 2.95628649 |
| 71 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.94860258 |
| 72 | positive regulation of cell cycle arrest (GO:0071158) | 2.93734359 |
| 73 | negative regulation of lymphocyte apoptotic process (GO:0070229) | 2.88979049 |
| 74 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.87124680 |
| 75 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.86560792 |
| 76 | regulation of T cell apoptotic process (GO:0070232) | 2.86035451 |
| 77 | negative T cell selection (GO:0043383) | 2.85655658 |
| 78 | positive regulation of ligase activity (GO:0051351) | 2.85652613 |
| 79 | respiratory chain complex IV assembly (GO:0008535) | 2.84258591 |
| 80 | regulation of cellular amine metabolic process (GO:0033238) | 2.83469499 |
| 81 | regulation of activation of Janus kinase activity (GO:0010533) | 2.83259092 |
| 82 | platelet dense granule organization (GO:0060155) | 2.81783660 |
| 83 | T cell receptor signaling pathway (GO:0050852) | 2.78837999 |
| 84 | macrophage chemotaxis (GO:0048246) | 2.78178698 |
| 85 | mannosylation (GO:0097502) | 2.77364553 |
| 86 | cellular defense response (GO:0006968) | 2.76118794 |
| 87 | natural killer cell activation (GO:0030101) | 2.75449623 |
| 88 | positive regulation of natural killer cell differentiation (GO:0032825) | 2.75275985 |
| 89 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 2.74960557 |
| 90 | T cell migration (GO:0072678) | 2.71974620 |
| 91 | mast cell activation (GO:0045576) | 2.71786539 |
| 92 | adenosine metabolic process (GO:0046085) | 2.68842869 |
| 93 | regulation of isotype switching to IgG isotypes (GO:0048302) | 2.66933555 |
| 94 | regulation of B cell receptor signaling pathway (GO:0050855) | 2.66828163 |
| 95 | pyrimidine ribonucleoside metabolic process (GO:0046131) | 2.63616067 |
| 96 | signal peptide processing (GO:0006465) | 2.62917668 |
| 97 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 2.62645044 |
| 98 | regulation of gamma-delta T cell differentiation (GO:0045586) | 2.58359075 |
| 99 | cytochrome complex assembly (GO:0017004) | 2.56892804 |
| 100 | regulation of calcium-mediated signaling (GO:0050848) | 2.56763312 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 4.51291998 |
| 2 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 4.07818679 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.73478002 |
| 4 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.66339049 |
| 5 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 3.47141280 |
| 6 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 3.38515181 |
| 7 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 3.32303201 |
| 8 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.07146286 |
| 9 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.95290918 |
| 10 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.91940427 |
| 11 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.75031194 |
| 12 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.72017076 |
| 13 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.61208155 |
| 14 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.56173955 |
| 15 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.45712613 |
| 16 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.44891117 |
| 17 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.43262355 |
| 18 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.37551866 |
| 19 | VDR_22108803_ChIP-Seq_LS180_Human | 2.18713407 |
| 20 | MYB_26560356_Chip-Seq_TH2_Human | 2.18266142 |
| 21 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.15054065 |
| 22 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.08307687 |
| 23 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.07968868 |
| 24 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.05612001 |
| 25 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.03874771 |
| 26 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 2.00815020 |
| 27 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.92131616 |
| 28 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.88468027 |
| 29 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.82424613 |
| 30 | GATA3_26560356_Chip-Seq_TH2_Human | 1.80837478 |
| 31 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.79686242 |
| 32 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.77733403 |
| 33 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.74624721 |
| 34 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.71870141 |
| 35 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.70368483 |
| 36 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.62880494 |
| 37 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.52440378 |
| 38 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.50648546 |
| 39 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.49709005 |
| 40 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.45632806 |
| 41 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.45308637 |
| 42 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.41460885 |
| 43 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.40830000 |
| 44 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.40759589 |
| 45 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.40133793 |
| 46 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.36718430 |
| 47 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.35383688 |
| 48 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.35079892 |
| 49 | AR_20517297_ChIP-Seq_VCAP_Human | 1.32688795 |
| 50 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.28090340 |
| 51 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.28090340 |
| 52 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.27380802 |
| 53 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.24917028 |
| 54 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.23720731 |
| 55 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.23510446 |
| 56 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.19429128 |
| 57 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.18934375 |
| 58 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.18585886 |
| 59 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.18102174 |
| 60 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.17478586 |
| 61 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.16276078 |
| 62 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.15815889 |
| 63 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.15815889 |
| 64 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.13446168 |
| 65 | MYB_26560356_Chip-Seq_TH1_Human | 1.12540982 |
| 66 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.12099091 |
| 67 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.11956324 |
| 68 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.11910338 |
| 69 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.10064541 |
| 70 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.09454851 |
| 71 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.09130995 |
| 72 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.05301701 |
| 73 | ERG_20517297_ChIP-Seq_VCAP_Human | 1.04549955 |
| 74 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.02231950 |
| 75 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.01652235 |
| 76 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.01267496 |
| 77 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.00628720 |
| 78 | EWS_26573619_Chip-Seq_HEK293_Human | 1.00303153 |
| 79 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 0.99530807 |
| 80 | MYC_19829295_ChIP-Seq_ESCs_Human | 0.99352792 |
| 81 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.98796277 |
| 82 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.98547321 |
| 83 | NCOR_22424771_ChIP-Seq_293T_Human | 0.96866003 |
| 84 | GATA3_26560356_Chip-Seq_TH1_Human | 0.96275001 |
| 85 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.95277514 |
| 86 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 0.95022932 |
| 87 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.94791450 |
| 88 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.94106613 |
| 89 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.93748773 |
| 90 | GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.92223861 |
| 91 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.90863282 |
| 92 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.90413860 |
| 93 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.90356664 |
| 94 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.90149844 |
| 95 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.89371418 |
| 96 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.89310204 |
| 97 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.89260408 |
| 98 | DCP1A_22483619_ChIP-Seq_HELA_Human | 0.88595464 |
| 99 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.88102544 |
| 100 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.87452244 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005671_abnormal_response_to | 5.60455547 |
| 2 | MP0009785_altered_susceptibility_to | 3.50170195 |
| 3 | MP0002102_abnormal_ear_morphology | 3.21833540 |
| 4 | MP0003763_abnormal_thymus_physiology | 2.95339057 |
| 5 | MP0002166_altered_tumor_susceptibility | 2.74623791 |
| 6 | MP0009333_abnormal_splenocyte_physiolog | 2.73117365 |
| 7 | MP0005387_immune_system_phenotype | 2.62973765 |
| 8 | MP0001790_abnormal_immune_system | 2.62973765 |
| 9 | MP0001835_abnormal_antigen_presentation | 2.62397745 |
| 10 | MP0005000_abnormal_immune_tolerance | 2.34728511 |
| 11 | MP0001800_abnormal_humoral_immune | 2.32702921 |
| 12 | MP0002006_tumorigenesis | 2.31988635 |
| 13 | MP0002148_abnormal_hypersensitivity_rea | 2.20162961 |
| 14 | MP0006082_CNS_inflammation | 2.11796095 |
| 15 | MP0002723_abnormal_immune_serum | 2.11467940 |
| 16 | MP0002420_abnormal_adaptive_immunity | 2.07203688 |
| 17 | MP0000372_irregular_coat_pigmentation | 2.04510961 |
| 18 | MP0005075_abnormal_melanosome_morpholog | 2.02972632 |
| 19 | MP0001819_abnormal_immune_cell | 2.01694528 |
| 20 | MP0003724_increased_susceptibility_to | 1.95701229 |
| 21 | MP0005025_abnormal_response_to | 1.95158110 |
| 22 | MP0003646_muscle_fatigue | 1.93334076 |
| 23 | MP0003866_abnormal_defecation | 1.90055263 |
| 24 | MP0002933_joint_inflammation | 1.88149928 |
| 25 | MP0000685_abnormal_immune_system | 1.82520945 |
| 26 | MP0006072_abnormal_retinal_apoptosis | 1.81889000 |
| 27 | MP0005360_urolithiasis | 1.77646551 |
| 28 | MP0002452_abnormal_antigen_presenting | 1.76183396 |
| 29 | MP0003436_decreased_susceptibility_to | 1.75300366 |
| 30 | MP0001986_abnormal_taste_sensitivity | 1.75076486 |
| 31 | MP0001873_stomach_inflammation | 1.60352148 |
| 32 | MP0005253_abnormal_eye_physiology | 1.52655203 |
| 33 | MP0006054_spinal_hemorrhage | 1.50404036 |
| 34 | MP0003011_delayed_dark_adaptation | 1.50375161 |
| 35 | MP0000716_abnormal_immune_system | 1.48061309 |
| 36 | MP0001845_abnormal_inflammatory_respons | 1.48025643 |
| 37 | MP0000569_abnormal_digit_pigmentation | 1.46038645 |
| 38 | MP0003786_premature_aging | 1.45096197 |
| 39 | MP0004147_increased_porphyrin_level | 1.43650237 |
| 40 | MP0002398_abnormal_bone_marrow | 1.42708921 |
| 41 | MP0002638_abnormal_pupillary_reflex | 1.40740494 |
| 42 | MP0002405_respiratory_system_inflammati | 1.36463454 |
| 43 | MP0010155_abnormal_intestine_physiology | 1.34777390 |
| 44 | MP0000689_abnormal_spleen_morphology | 1.33194497 |
| 45 | MP0004043_abnormal_pH_regulation | 1.32901337 |
| 46 | MP0009764_decreased_sensitivity_to | 1.30305395 |
| 47 | MP0008875_abnormal_xenobiotic_pharmacok | 1.29449651 |
| 48 | MP0001853_heart_inflammation | 1.27963583 |
| 49 | MP0001905_abnormal_dopamine_level | 1.23003442 |
| 50 | MP0000703_abnormal_thymus_morphology | 1.21271489 |
| 51 | MP0002722_abnormal_immune_system | 1.19434513 |
| 52 | MP0005645_abnormal_hypothalamus_physiol | 1.17996872 |
| 53 | MP0003045_fibrosis | 1.17206973 |
| 54 | MP0001919_abnormal_reproductive_system | 1.15671042 |
| 55 | MP0002429_abnormal_blood_cell | 1.15427422 |
| 56 | MP0004145_abnormal_muscle_electrophysio | 1.14692377 |
| 57 | MP0002736_abnormal_nociception_after | 1.12711913 |
| 58 | MP0002234_abnormal_pharynx_morphology | 1.11555427 |
| 59 | MP0002837_dystrophic_cardiac_calcinosis | 1.10363494 |
| 60 | MP0002138_abnormal_hepatobiliary_system | 1.08317262 |
| 61 | MP0005464_abnormal_platelet_physiology | 1.07972482 |
| 62 | MP0003806_abnormal_nucleotide_metabolis | 1.06998460 |
| 63 | MP0005084_abnormal_gallbladder_morpholo | 1.06226202 |
| 64 | MP0001984_abnormal_olfaction | 1.04286566 |
| 65 | MP0008872_abnormal_physiological_respon | 1.03043515 |
| 66 | MP0001764_abnormal_homeostasis | 1.02548334 |
| 67 | MP0006036_abnormal_mitochondrial_physio | 1.02380441 |
| 68 | MP0002277_abnormal_respiratory_mucosa | 1.01863050 |
| 69 | MP0002419_abnormal_innate_immunity | 1.01410070 |
| 70 | MP0001968_abnormal_touch/_nociception | 0.98376688 |
| 71 | MP0001533_abnormal_skeleton_physiology | 0.94773610 |
| 72 | MP0005551_abnormal_eye_electrophysiolog | 0.94621983 |
| 73 | MP0009763_increased_sensitivity_to | 0.94556346 |
| 74 | MP0005379_endocrine/exocrine_gland_phen | 0.94403217 |
| 75 | MP0002095_abnormal_skin_pigmentation | 0.93814410 |
| 76 | MP0008469_abnormal_protein_level | 0.93477313 |
| 77 | MP0006035_abnormal_mitochondrial_morpho | 0.92923972 |
| 78 | MP0002909_abnormal_adrenal_gland | 0.89278050 |
| 79 | MP0003137_abnormal_impulse_conducting | 0.88624545 |
| 80 | MP0003195_calcinosis | 0.87368718 |
| 81 | MP0003448_altered_tumor_morphology | 0.86016402 |
| 82 | MP0002693_abnormal_pancreas_physiology | 0.84999362 |
| 83 | MP0009765_abnormal_xenobiotic_induced | 0.77760252 |
| 84 | MP0008877_abnormal_DNA_methylation | 0.75710187 |
| 85 | MP0005636_abnormal_mineral_homeostasis | 0.75204216 |
| 86 | MP0004142_abnormal_muscle_tone | 0.75156759 |
| 87 | MP0001501_abnormal_sleep_pattern | 0.74766747 |
| 88 | MP0008058_abnormal_DNA_repair | 0.72959411 |
| 89 | MP0002876_abnormal_thyroid_physiology | 0.71697889 |
| 90 | MP0002019_abnormal_tumor_incidence | 0.70897614 |
| 91 | MP0008873_increased_physiological_sensi | 0.70865914 |
| 92 | MP0005389_reproductive_system_phenotype | 0.70037948 |
| 93 | MP0002090_abnormal_vision | 0.69857874 |
| 94 | MP0003252_abnormal_bile_duct | 0.69758564 |
| 95 | MP0005167_abnormal_blood-brain_barrier | 0.68291032 |
| 96 | MP0002163_abnormal_gland_morphology | 0.67352985 |
| 97 | MP0001243_abnormal_dermal_layer | 0.66681720 |
| 98 | MP0005310_abnormal_salivary_gland | 0.64851659 |
| 99 | MP0004947_skin_inflammation | 0.63680898 |
| 100 | MP0010386_abnormal_urinary_bladder | 0.63012452 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | T lymphocytopenia (HP:0005403) | 5.11460984 |
| 2 | Aplastic anemia (HP:0001915) | 4.93972730 |
| 3 | Abnormality of T cell number (HP:0011839) | 4.80108570 |
| 4 | IgG deficiency (HP:0004315) | 4.73485497 |
| 5 | Severe combined immunodeficiency (HP:0004430) | 4.29258704 |
| 6 | Mitochondrial inheritance (HP:0001427) | 3.98359235 |
| 7 | Hepatocellular necrosis (HP:0001404) | 3.96442098 |
| 8 | Abnormality of T cells (HP:0002843) | 3.84183623 |
| 9 | Increased CSF lactate (HP:0002490) | 3.77345670 |
| 10 | Acute necrotizing encephalopathy (HP:0006965) | 3.71318841 |
| 11 | Hepatic necrosis (HP:0002605) | 3.66022767 |
| 12 | Increased IgM level (HP:0003496) | 3.48707278 |
| 13 | Increased hepatocellular lipid droplets (HP:0006565) | 3.42318262 |
| 14 | Hypoproteinemia (HP:0003075) | 3.34839970 |
| 15 | Thyroiditis (HP:0100646) | 3.32244560 |
| 16 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.31385616 |
| 17 | Autoimmune hemolytic anemia (HP:0001890) | 3.27536193 |
| 18 | Combined immunodeficiency (HP:0005387) | 3.27164129 |
| 19 | Chronic diarrhea (HP:0002028) | 3.27029839 |
| 20 | Lipid accumulation in hepatocytes (HP:0006561) | 3.23300901 |
| 21 | 3-Methylglutaconic aciduria (HP:0003535) | 3.22276510 |
| 22 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.20215144 |
| 23 | Acute encephalopathy (HP:0006846) | 3.19214411 |
| 24 | Abnormality of eosinophils (HP:0001879) | 3.14338319 |
| 25 | Progressive macrocephaly (HP:0004481) | 3.09481855 |
| 26 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.08241951 |
| 27 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.08241951 |
| 28 | Pancreatic cysts (HP:0001737) | 3.01354861 |
| 29 | Generalized aminoaciduria (HP:0002909) | 2.99460161 |
| 30 | Type I transferrin isoform profile (HP:0003642) | 2.98542642 |
| 31 | Renal cortical cysts (HP:0000803) | 2.94332678 |
| 32 | Congenital stationary night blindness (HP:0007642) | 2.93888594 |
| 33 | Stomatitis (HP:0010280) | 2.84347184 |
| 34 | Abnormality of T cell physiology (HP:0011840) | 2.82739667 |
| 35 | IgM deficiency (HP:0002850) | 2.80149268 |
| 36 | Increased serum lactate (HP:0002151) | 2.68241277 |
| 37 | Renal Fanconi syndrome (HP:0001994) | 2.62804724 |
| 38 | Abnormality of B cell number (HP:0010975) | 2.62758307 |
| 39 | Increased intramyocellular lipid droplets (HP:0012240) | 2.56902060 |
| 40 | B lymphocytopenia (HP:0010976) | 2.54134395 |
| 41 | Abnormal protein glycosylation (HP:0012346) | 2.51661364 |
| 42 | Abnormal glycosylation (HP:0012345) | 2.51661364 |
| 43 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.51661364 |
| 44 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.51661364 |
| 45 | Cerebral edema (HP:0002181) | 2.49308037 |
| 46 | Abnormal albumin level (HP:0012116) | 2.48659433 |
| 47 | Hypoalbuminemia (HP:0003073) | 2.48659433 |
| 48 | Lactic acidosis (HP:0003128) | 2.47858689 |
| 49 | Eosinophilia (HP:0001880) | 2.46773905 |
| 50 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.40685325 |
| 51 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.40480710 |
| 52 | Abolished electroretinogram (ERG) (HP:0000550) | 2.38584224 |
| 53 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.38204713 |
| 54 | Recurrent cutaneous fungal infections (HP:0011370) | 2.36070876 |
| 55 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.36070876 |
| 56 | Abnormality of the prostate (HP:0008775) | 2.29848330 |
| 57 | Respiratory failure (HP:0002878) | 2.29240328 |
| 58 | Abnormality of the renal cortex (HP:0011035) | 2.27168730 |
| 59 | True hermaphroditism (HP:0010459) | 2.27152532 |
| 60 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.26188030 |
| 61 | Pancreatic fibrosis (HP:0100732) | 2.25212521 |
| 62 | Exertional dyspnea (HP:0002875) | 2.22214022 |
| 63 | Pustule (HP:0200039) | 2.22123522 |
| 64 | Pancytopenia (HP:0001876) | 2.20900696 |
| 65 | Increased muscle lipid content (HP:0009058) | 2.20766875 |
| 66 | Encephalitis (HP:0002383) | 2.20605454 |
| 67 | Hypothermia (HP:0002045) | 2.20438999 |
| 68 | Hyperalaninemia (HP:0003348) | 2.17080428 |
| 69 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.17080428 |
| 70 | Abnormality of alanine metabolism (HP:0010916) | 2.17080428 |
| 71 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.16064259 |
| 72 | Molar tooth sign on MRI (HP:0002419) | 2.14948796 |
| 73 | Abnormality of midbrain morphology (HP:0002418) | 2.14948796 |
| 74 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.09229596 |
| 75 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.07103874 |
| 76 | Lethargy (HP:0001254) | 2.06550849 |
| 77 | Constricted visual fields (HP:0001133) | 2.04938027 |
| 78 | Autoimmune thrombocytopenia (HP:0001973) | 2.03894188 |
| 79 | Optic disc pallor (HP:0000543) | 2.03758668 |
| 80 | Leukocytosis (HP:0001974) | 2.02881490 |
| 81 | Dicarboxylic aciduria (HP:0003215) | 2.01816480 |
| 82 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.01816480 |
| 83 | Joint swelling (HP:0001386) | 1.98438391 |
| 84 | Recurrent bronchitis (HP:0002837) | 1.96481970 |
| 85 | Acute hepatic failure (HP:0006554) | 1.96462345 |
| 86 | Lymphopenia (HP:0001888) | 1.93805131 |
| 87 | Reduced antithrombin III activity (HP:0001976) | 1.92644218 |
| 88 | Attenuation of retinal blood vessels (HP:0007843) | 1.92527621 |
| 89 | Oral leukoplakia (HP:0002745) | 1.89350326 |
| 90 | Glycosuria (HP:0003076) | 1.89328606 |
| 91 | Abnormality of urine glucose concentration (HP:0011016) | 1.89328606 |
| 92 | Methylmalonic aciduria (HP:0012120) | 1.89203780 |
| 93 | CNS demyelination (HP:0007305) | 1.85840420 |
| 94 | Exercise intolerance (HP:0003546) | 1.85062655 |
| 95 | Lymphoma (HP:0002665) | 1.84489739 |
| 96 | Hypoplasia of the uterus (HP:0000013) | 1.82072416 |
| 97 | Granulocytopenia (HP:0001913) | 1.79182298 |
| 98 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 1.78811669 |
| 99 | Polydipsia (HP:0001959) | 1.78059878 |
| 100 | Abnormal drinking behavior (HP:0030082) | 1.78059878 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TXK | 6.25418975 |
| 2 | KDR | 4.27656106 |
| 3 | TESK2 | 4.06906838 |
| 4 | MAP3K12 | 2.88253036 |
| 5 | TESK1 | 2.62446425 |
| 6 | TRIM28 | 2.60487346 |
| 7 | TAOK3 | 2.54900560 |
| 8 | ZAK | 2.45801594 |
| 9 | MST4 | 2.42443960 |
| 10 | MAP4K2 | 2.39727889 |
| 11 | LIMK1 | 2.32106023 |
| 12 | BCKDK | 2.31963841 |
| 13 | TLK1 | 2.25685649 |
| 14 | VRK2 | 2.09538343 |
| 15 | MAPKAPK3 | 1.84393588 |
| 16 | BUB1 | 1.83908750 |
| 17 | MAP4K1 | 1.81766148 |
| 18 | ITK | 1.74683365 |
| 19 | ADRBK2 | 1.66145012 |
| 20 | SCYL2 | 1.64617680 |
| 21 | BCR | 1.61033316 |
| 22 | SIK3 | 1.60219936 |
| 23 | VRK1 | 1.47135999 |
| 24 | MYLK | 1.41393553 |
| 25 | TIE1 | 1.36723081 |
| 26 | EIF2AK3 | 1.35955071 |
| 27 | DAPK1 | 1.33014161 |
| 28 | ERBB3 | 1.29793409 |
| 29 | SRPK1 | 1.27255135 |
| 30 | GRK1 | 1.22179883 |
| 31 | TEC | 1.18318498 |
| 32 | FES | 1.10367151 |
| 33 | CSNK1G3 | 1.10136345 |
| 34 | FRK | 1.01432563 |
| 35 | NEK1 | 1.00872209 |
| 36 | PINK1 | 0.96519302 |
| 37 | RPS6KA4 | 0.93156742 |
| 38 | NUAK1 | 0.93122113 |
| 39 | CSNK1A1L | 0.92094925 |
| 40 | SYK | 0.90873689 |
| 41 | CSNK1G1 | 0.85650478 |
| 42 | WNK4 | 0.84790747 |
| 43 | GRK6 | 0.80966060 |
| 44 | ZAP70 | 0.80683287 |
| 45 | CSNK1G2 | 0.80673974 |
| 46 | IKBKB | 0.79592008 |
| 47 | LCK | 0.79550501 |
| 48 | PDK2 | 0.78230051 |
| 49 | BMPR1B | 0.73109959 |
| 50 | IKBKE | 0.69671459 |
| 51 | WNK3 | 0.67231079 |
| 52 | LYN | 0.65419502 |
| 53 | RPS6KA5 | 0.65035038 |
| 54 | CSK | 0.64045330 |
| 55 | PRKCQ | 0.63463186 |
| 56 | BTK | 0.61929818 |
| 57 | KIT | 0.60343472 |
| 58 | INSRR | 0.58544283 |
| 59 | OXSR1 | 0.56715530 |
| 60 | JAK3 | 0.56522449 |
| 61 | TNK2 | 0.55553610 |
| 62 | MAP2K7 | 0.53801071 |
| 63 | EIF2AK1 | 0.52426449 |
| 64 | MAP3K11 | 0.51675787 |
| 65 | STK39 | 0.50492904 |
| 66 | TBK1 | 0.49202961 |
| 67 | IGF1R | 0.48701576 |
| 68 | GRK7 | 0.44987724 |
| 69 | PIK3CG | 0.44722229 |
| 70 | TAF1 | 0.42013982 |
| 71 | GRK5 | 0.38255586 |
| 72 | CAMKK2 | 0.37285400 |
| 73 | MUSK | 0.34914643 |
| 74 | JAK1 | 0.34599214 |
| 75 | MAP2K6 | 0.34448749 |
| 76 | EIF2AK2 | 0.32939434 |
| 77 | MINK1 | 0.31451006 |
| 78 | ABL1 | 0.31105442 |
| 79 | ROCK1 | 0.30468390 |
| 80 | PAK4 | 0.30213151 |
| 81 | CSNK1A1 | 0.30076271 |
| 82 | MATK | 0.29794851 |
| 83 | MAP2K2 | 0.29350927 |
| 84 | PAK3 | 0.29024163 |
| 85 | PRKCA | 0.28745098 |
| 86 | CSNK2A1 | 0.28729639 |
| 87 | AURKA | 0.26787587 |
| 88 | PLK3 | 0.26772264 |
| 89 | CLK1 | 0.26516455 |
| 90 | PRKCE | 0.25997045 |
| 91 | CAMK2A | 0.25547321 |
| 92 | TYK2 | 0.24905356 |
| 93 | PASK | 0.24745360 |
| 94 | PLK2 | 0.23042856 |
| 95 | PHKG2 | 0.22810061 |
| 96 | PHKG1 | 0.22810061 |
| 97 | FYN | 0.22289352 |
| 98 | PAK1 | 0.20809566 |
| 99 | EGFR | 0.20480651 |
| 100 | CSF1R | 0.20465471 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.73783633 |
| 2 | Primary immunodeficiency_Homo sapiens_hsa05340 | 4.51573629 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.34768713 |
| 4 | Parkinsons disease_Homo sapiens_hsa05012 | 2.93163845 |
| 5 | Protein export_Homo sapiens_hsa03060 | 2.70854980 |
| 6 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.67163404 |
| 7 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.62783044 |
| 8 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.28351924 |
| 9 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.13624620 |
| 10 | Allograft rejection_Homo sapiens_hsa05330 | 2.13215914 |
| 11 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 2.05036822 |
| 12 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.89519135 |
| 13 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.87788423 |
| 14 | Alzheimers disease_Homo sapiens_hsa05010 | 1.85267121 |
| 15 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.82802645 |
| 16 | RNA polymerase_Homo sapiens_hsa03020 | 1.68413268 |
| 17 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.67118920 |
| 18 | Huntingtons disease_Homo sapiens_hsa05016 | 1.59736923 |
| 19 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.56641870 |
| 20 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.56261943 |
| 21 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.55737227 |
| 22 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.41490108 |
| 23 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.39528575 |
| 24 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.35913874 |
| 25 | Phototransduction_Homo sapiens_hsa04744 | 1.32761849 |
| 26 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.25818187 |
| 27 | Homologous recombination_Homo sapiens_hsa03440 | 1.24486580 |
| 28 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.20831068 |
| 29 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.20400004 |
| 30 | Asthma_Homo sapiens_hsa05310 | 1.18758059 |
| 31 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.17963939 |
| 32 | Peroxisome_Homo sapiens_hsa04146 | 1.08749366 |
| 33 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.07241556 |
| 34 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.06787342 |
| 35 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.06748096 |
| 36 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.05326106 |
| 37 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.02415160 |
| 38 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.01292162 |
| 39 | Shigellosis_Homo sapiens_hsa05131 | 1.00823975 |
| 40 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.96229671 |
| 41 | Measles_Homo sapiens_hsa05162 | 0.94647609 |
| 42 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.94349725 |
| 43 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.87780665 |
| 44 | RNA degradation_Homo sapiens_hsa03018 | 0.84959645 |
| 45 | Salmonella infection_Homo sapiens_hsa05132 | 0.84252724 |
| 46 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.82746702 |
| 47 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.81446981 |
| 48 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.76765806 |
| 49 | Basal transcription factors_Homo sapiens_hsa03022 | 0.76643008 |
| 50 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.74674358 |
| 51 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.72812284 |
| 52 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.72357564 |
| 53 | Mismatch repair_Homo sapiens_hsa03430 | 0.72166136 |
| 54 | Viral myocarditis_Homo sapiens_hsa05416 | 0.71433691 |
| 55 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.71182678 |
| 56 | Base excision repair_Homo sapiens_hsa03410 | 0.69295400 |
| 57 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.68169542 |
| 58 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.67514230 |
| 59 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.67173145 |
| 60 | Retinol metabolism_Homo sapiens_hsa00830 | 0.67120429 |
| 61 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.67009634 |
| 62 | DNA replication_Homo sapiens_hsa03030 | 0.66588427 |
| 63 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.66532531 |
| 64 | RNA transport_Homo sapiens_hsa03013 | 0.66149067 |
| 65 | Purine metabolism_Homo sapiens_hsa00230 | 0.60284928 |
| 66 | Spliceosome_Homo sapiens_hsa03040 | 0.55600799 |
| 67 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.54095679 |
| 68 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.53743316 |
| 69 | Legionellosis_Homo sapiens_hsa05134 | 0.53277902 |
| 70 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.51843108 |
| 71 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.51304382 |
| 72 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.51034491 |
| 73 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.50612861 |
| 74 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.49465986 |
| 75 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.49155108 |
| 76 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.48956612 |
| 77 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.48808507 |
| 78 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.46937150 |
| 79 | Metabolic pathways_Homo sapiens_hsa01100 | 0.45671704 |
| 80 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.45133534 |
| 81 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.44099740 |
| 82 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.43192017 |
| 83 | Olfactory transduction_Homo sapiens_hsa04740 | 0.43014575 |
| 84 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.42643233 |
| 85 | Ribosome_Homo sapiens_hsa03010 | 0.42552791 |
| 86 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.41494479 |
| 87 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.38764441 |
| 88 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.38339680 |
| 89 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.38270708 |
| 90 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.36375957 |
| 91 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.36210908 |
| 92 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.35590155 |
| 93 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.35493637 |
| 94 | Malaria_Homo sapiens_hsa05144 | 0.35346797 |
| 95 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.35326562 |
| 96 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.34188531 |
| 97 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.33264818 |
| 98 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.31074535 |
| 99 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.28178512 |
| 100 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.25116790 |

