YWHAZP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)8.25823780
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.78605724
3cytidine metabolic process (GO:0046087)7.76361863
4cytidine catabolic process (GO:0006216)7.76361863
5cytidine deamination (GO:0009972)7.76361863
6pyrimidine ribonucleoside catabolic process (GO:0046133)6.94394413
7Arp2/3 complex-mediated actin nucleation (GO:0034314)5.67384753
8actin nucleation (GO:0045010)5.05541024
9positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.62745894
10positive regulation of natural killer cell mediated immunity (GO:0002717)4.55243903
11cellular response to interleukin-15 (GO:0071350)4.43749641
12protein neddylation (GO:0045116)4.16649033
13regulation of cellular amino acid metabolic process (GO:0006521)4.11109611
14negative regulation of T cell apoptotic process (GO:0070233)4.06410005
15regulation of regulatory T cell differentiation (GO:0045589)4.02712768
16positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.01869080
17DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.78613968
18proteasome assembly (GO:0043248)3.78049711
19regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.75488713
20regulation of natural killer cell mediated immunity (GO:0002715)3.75488713
21regulation of leukocyte mediated cytotoxicity (GO:0001910)3.73328636
22negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.69245320
23sequestering of actin monomers (GO:0042989)3.66128074
24intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.66065160
25signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.66065160
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.65813837
27signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.64711489
28signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.64711489
29signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.64711489
30mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.64681145
31positive regulation of interleukin-8 secretion (GO:2000484)3.63841046
32response to interleukin-15 (GO:0070672)3.51993466
33eosinophil chemotaxis (GO:0048245)3.50958686
34pyrimidine nucleoside catabolic process (GO:0046135)3.49167995
35positive regulation of cell killing (GO:0031343)3.47300290
36energy coupled proton transport, down electrochemical gradient (GO:0015985)3.47215849
37ATP synthesis coupled proton transport (GO:0015986)3.47215849
38signal transduction involved in DNA damage checkpoint (GO:0072422)3.44197402
39signal transduction involved in DNA integrity checkpoint (GO:0072401)3.44197402
40positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.43951799
41antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.42973697
42positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.42664648
43signal transduction involved in cell cycle checkpoint (GO:0072395)3.41343984
44positive regulation of calcium-mediated signaling (GO:0050850)3.39342290
45response to interferon-beta (GO:0035456)3.33766608
46positive regulation of T cell mediated cytotoxicity (GO:0001916)3.32485441
47negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.30774114
48negative regulation of ligase activity (GO:0051352)3.30774114
49mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.28982976
50regulation of T cell mediated cytotoxicity (GO:0001914)3.27666622
51regulation of cell killing (GO:0031341)3.26576094
52antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.22470286
53regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.22080969
54positive regulation of defense response to virus by host (GO:0002230)3.21974185
55negative regulation by host of viral transcription (GO:0043922)3.21119707
56tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.19929114
57RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.19929114
58regulation of chronic inflammatory response (GO:0002676)3.19927136
59eosinophil migration (GO:0072677)3.16398701
60establishment of protein localization to mitochondrial membrane (GO:0090151)3.15042967
61regulation of interleukin-8 secretion (GO:2000482)3.12789679
62adaptation of signaling pathway (GO:0023058)3.09738248
63base-excision repair, AP site formation (GO:0006285)3.06936240
64regulation of T cell receptor signaling pathway (GO:0050856)3.02773392
65negative regulation of viral genome replication (GO:0045071)3.02711302
66antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.98983365
67respiratory electron transport chain (GO:0022904)2.97223940
68cellular response to interferon-beta (GO:0035458)2.97211314
69electron transport chain (GO:0022900)2.96268404
70cytolysis (GO:0019835)2.95628649
71positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.94860258
72positive regulation of cell cycle arrest (GO:0071158)2.93734359
73negative regulation of lymphocyte apoptotic process (GO:0070229)2.88979049
74DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.87124680
75anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.86560792
76regulation of T cell apoptotic process (GO:0070232)2.86035451
77negative T cell selection (GO:0043383)2.85655658
78positive regulation of ligase activity (GO:0051351)2.85652613
79respiratory chain complex IV assembly (GO:0008535)2.84258591
80regulation of cellular amine metabolic process (GO:0033238)2.83469499
81regulation of activation of Janus kinase activity (GO:0010533)2.83259092
82platelet dense granule organization (GO:0060155)2.81783660
83T cell receptor signaling pathway (GO:0050852)2.78837999
84macrophage chemotaxis (GO:0048246)2.78178698
85mannosylation (GO:0097502)2.77364553
86cellular defense response (GO:0006968)2.76118794
87natural killer cell activation (GO:0030101)2.75449623
88positive regulation of natural killer cell differentiation (GO:0032825)2.75275985
89regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.74960557
90T cell migration (GO:0072678)2.71974620
91mast cell activation (GO:0045576)2.71786539
92adenosine metabolic process (GO:0046085)2.68842869
93regulation of isotype switching to IgG isotypes (GO:0048302)2.66933555
94regulation of B cell receptor signaling pathway (GO:0050855)2.66828163
95pyrimidine ribonucleoside metabolic process (GO:0046131)2.63616067
96signal peptide processing (GO:0006465)2.62917668
97deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.62645044
98regulation of gamma-delta T cell differentiation (GO:0045586)2.58359075
99cytochrome complex assembly (GO:0017004)2.56892804
100regulation of calcium-mediated signaling (GO:0050848)2.56763312

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.51291998
2ELF1_17652178_ChIP-ChIP_JURKAT_Human4.07818679
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.73478002
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.66339049
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.47141280
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.38515181
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.32303201
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.07146286
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.95290918
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.91940427
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.75031194
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.72017076
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.61208155
14VDR_23849224_ChIP-Seq_CD4+_Human2.56173955
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.45712613
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.44891117
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.43262355
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.37551866
19VDR_22108803_ChIP-Seq_LS180_Human2.18713407
20MYB_26560356_Chip-Seq_TH2_Human2.18266142
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.15054065
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.08307687
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.07968868
24ELK1_19687146_ChIP-ChIP_HELA_Human2.05612001
25ZNF274_21170338_ChIP-Seq_K562_Hela2.03874771
26IRF8_21731497_ChIP-ChIP_J774_Mouse2.00815020
27FOXP3_21729870_ChIP-Seq_TREG_Human1.92131616
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88468027
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.82424613
30GATA3_26560356_Chip-Seq_TH2_Human1.80837478
31STAT4_19710469_ChIP-ChIP_TH1__Mouse1.79686242
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.77733403
33GATA3_27048872_Chip-Seq_THYMUS_Human1.74624721
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.71870141
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.70368483
36TAF15_26573619_Chip-Seq_HEK293_Human1.62880494
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.52440378
38RUNX_20019798_ChIP-Seq_JUKART_Human1.50648546
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.49709005
40MYC_18940864_ChIP-ChIP_HL60_Human1.45632806
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45308637
42IGF1R_20145208_ChIP-Seq_DFB_Human1.41460885
43PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.40830000
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40759589
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40133793
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36718430
47TP53_22573176_ChIP-Seq_HFKS_Human1.35383688
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35079892
49AR_20517297_ChIP-Seq_VCAP_Human1.32688795
50FOXA1_25329375_ChIP-Seq_VCAP_Human1.28090340
51FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28090340
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27380802
53HTT_18923047_ChIP-ChIP_STHdh_Human1.24917028
54ELK1_22589737_ChIP-Seq_MCF10A_Human1.23720731
55TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.23510446
56STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.19429128
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.18934375
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18585886
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18102174
60CIITA_25753668_ChIP-Seq_RAJI_Human1.17478586
61PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16276078
62NANOG_19829295_ChIP-Seq_ESCs_Human1.15815889
63SOX2_19829295_ChIP-Seq_ESCs_Human1.15815889
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13446168
65MYB_26560356_Chip-Seq_TH1_Human1.12540982
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12099091
67RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.11956324
68RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.11910338
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.10064541
70YY1_21170310_ChIP-Seq_MESCs_Mouse1.09454851
71EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.09130995
72FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05301701
73ERG_20517297_ChIP-Seq_VCAP_Human1.04549955
74PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02231950
75GABP_19822575_ChIP-Seq_HepG2_Human1.01652235
76AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01267496
77FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00628720
78EWS_26573619_Chip-Seq_HEK293_Human1.00303153
79GATA6_21074721_ChIP-Seq_CACO-2_Human0.99530807
80MYC_19829295_ChIP-Seq_ESCs_Human0.99352792
81SPI1_23547873_ChIP-Seq_NB4_Human0.98796277
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98547321
83NCOR_22424771_ChIP-Seq_293T_Human0.96866003
84GATA3_26560356_Chip-Seq_TH1_Human0.96275001
85FOXH1_21741376_ChIP-Seq_EPCs_Human0.95277514
86GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.95022932
87IRF1_19129219_ChIP-ChIP_H3396_Human0.94791450
88EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94106613
89NANOG_20526341_ChIP-Seq_ESCs_Human0.93748773
90GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.92223861
91ER_23166858_ChIP-Seq_MCF-7_Human0.90863282
92HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.90413860
93RBPJ_21746931_ChIP-Seq_IB4_Human0.90356664
94CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90149844
95CRX_20693478_ChIP-Seq_RETINA_Mouse0.89371418
96ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89310204
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89260408
98DCP1A_22483619_ChIP-Seq_HELA_Human0.88595464
99TAF2_19829295_ChIP-Seq_ESCs_Human0.88102544
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.87452244

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.60455547
2MP0009785_altered_susceptibility_to3.50170195
3MP0002102_abnormal_ear_morphology3.21833540
4MP0003763_abnormal_thymus_physiology2.95339057
5MP0002166_altered_tumor_susceptibility2.74623791
6MP0009333_abnormal_splenocyte_physiolog2.73117365
7MP0005387_immune_system_phenotype2.62973765
8MP0001790_abnormal_immune_system2.62973765
9MP0001835_abnormal_antigen_presentation2.62397745
10MP0005000_abnormal_immune_tolerance2.34728511
11MP0001800_abnormal_humoral_immune2.32702921
12MP0002006_tumorigenesis2.31988635
13MP0002148_abnormal_hypersensitivity_rea2.20162961
14MP0006082_CNS_inflammation2.11796095
15MP0002723_abnormal_immune_serum2.11467940
16MP0002420_abnormal_adaptive_immunity2.07203688
17MP0000372_irregular_coat_pigmentation2.04510961
18MP0005075_abnormal_melanosome_morpholog2.02972632
19MP0001819_abnormal_immune_cell2.01694528
20MP0003724_increased_susceptibility_to1.95701229
21MP0005025_abnormal_response_to1.95158110
22MP0003646_muscle_fatigue1.93334076
23MP0003866_abnormal_defecation1.90055263
24MP0002933_joint_inflammation1.88149928
25MP0000685_abnormal_immune_system1.82520945
26MP0006072_abnormal_retinal_apoptosis1.81889000
27MP0005360_urolithiasis1.77646551
28MP0002452_abnormal_antigen_presenting1.76183396
29MP0003436_decreased_susceptibility_to1.75300366
30MP0001986_abnormal_taste_sensitivity1.75076486
31MP0001873_stomach_inflammation1.60352148
32MP0005253_abnormal_eye_physiology1.52655203
33MP0006054_spinal_hemorrhage1.50404036
34MP0003011_delayed_dark_adaptation1.50375161
35MP0000716_abnormal_immune_system1.48061309
36MP0001845_abnormal_inflammatory_respons1.48025643
37MP0000569_abnormal_digit_pigmentation1.46038645
38MP0003786_premature_aging1.45096197
39MP0004147_increased_porphyrin_level1.43650237
40MP0002398_abnormal_bone_marrow1.42708921
41MP0002638_abnormal_pupillary_reflex1.40740494
42MP0002405_respiratory_system_inflammati1.36463454
43MP0010155_abnormal_intestine_physiology1.34777390
44MP0000689_abnormal_spleen_morphology1.33194497
45MP0004043_abnormal_pH_regulation1.32901337
46MP0009764_decreased_sensitivity_to1.30305395
47MP0008875_abnormal_xenobiotic_pharmacok1.29449651
48MP0001853_heart_inflammation1.27963583
49MP0001905_abnormal_dopamine_level1.23003442
50MP0000703_abnormal_thymus_morphology1.21271489
51MP0002722_abnormal_immune_system1.19434513
52MP0005645_abnormal_hypothalamus_physiol1.17996872
53MP0003045_fibrosis1.17206973
54MP0001919_abnormal_reproductive_system1.15671042
55MP0002429_abnormal_blood_cell1.15427422
56MP0004145_abnormal_muscle_electrophysio1.14692377
57MP0002736_abnormal_nociception_after1.12711913
58MP0002234_abnormal_pharynx_morphology1.11555427
59MP0002837_dystrophic_cardiac_calcinosis1.10363494
60MP0002138_abnormal_hepatobiliary_system1.08317262
61MP0005464_abnormal_platelet_physiology1.07972482
62MP0003806_abnormal_nucleotide_metabolis1.06998460
63MP0005084_abnormal_gallbladder_morpholo1.06226202
64MP0001984_abnormal_olfaction1.04286566
65MP0008872_abnormal_physiological_respon1.03043515
66MP0001764_abnormal_homeostasis1.02548334
67MP0006036_abnormal_mitochondrial_physio1.02380441
68MP0002277_abnormal_respiratory_mucosa1.01863050
69MP0002419_abnormal_innate_immunity1.01410070
70MP0001968_abnormal_touch/_nociception0.98376688
71MP0001533_abnormal_skeleton_physiology0.94773610
72MP0005551_abnormal_eye_electrophysiolog0.94621983
73MP0009763_increased_sensitivity_to0.94556346
74MP0005379_endocrine/exocrine_gland_phen0.94403217
75MP0002095_abnormal_skin_pigmentation0.93814410
76MP0008469_abnormal_protein_level0.93477313
77MP0006035_abnormal_mitochondrial_morpho0.92923972
78MP0002909_abnormal_adrenal_gland0.89278050
79MP0003137_abnormal_impulse_conducting0.88624545
80MP0003195_calcinosis0.87368718
81MP0003448_altered_tumor_morphology0.86016402
82MP0002693_abnormal_pancreas_physiology0.84999362
83MP0009765_abnormal_xenobiotic_induced0.77760252
84MP0008877_abnormal_DNA_methylation0.75710187
85MP0005636_abnormal_mineral_homeostasis0.75204216
86MP0004142_abnormal_muscle_tone0.75156759
87MP0001501_abnormal_sleep_pattern0.74766747
88MP0008058_abnormal_DNA_repair0.72959411
89MP0002876_abnormal_thyroid_physiology0.71697889
90MP0002019_abnormal_tumor_incidence0.70897614
91MP0008873_increased_physiological_sensi0.70865914
92MP0005389_reproductive_system_phenotype0.70037948
93MP0002090_abnormal_vision0.69857874
94MP0003252_abnormal_bile_duct0.69758564
95MP0005167_abnormal_blood-brain_barrier0.68291032
96MP0002163_abnormal_gland_morphology0.67352985
97MP0001243_abnormal_dermal_layer0.66681720
98MP0005310_abnormal_salivary_gland0.64851659
99MP0004947_skin_inflammation0.63680898
100MP0010386_abnormal_urinary_bladder0.63012452

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.11460984
2Aplastic anemia (HP:0001915)4.93972730
3Abnormality of T cell number (HP:0011839)4.80108570
4IgG deficiency (HP:0004315)4.73485497
5Severe combined immunodeficiency (HP:0004430)4.29258704
6Mitochondrial inheritance (HP:0001427)3.98359235
7Hepatocellular necrosis (HP:0001404)3.96442098
8Abnormality of T cells (HP:0002843)3.84183623
9Increased CSF lactate (HP:0002490)3.77345670
10Acute necrotizing encephalopathy (HP:0006965)3.71318841
11Hepatic necrosis (HP:0002605)3.66022767
12Increased IgM level (HP:0003496)3.48707278
13Increased hepatocellular lipid droplets (HP:0006565)3.42318262
14Hypoproteinemia (HP:0003075)3.34839970
15Thyroiditis (HP:0100646)3.32244560
16Abnormal mitochondria in muscle tissue (HP:0008316)3.31385616
17Autoimmune hemolytic anemia (HP:0001890)3.27536193
18Combined immunodeficiency (HP:0005387)3.27164129
19Chronic diarrhea (HP:0002028)3.27029839
20Lipid accumulation in hepatocytes (HP:0006561)3.23300901
213-Methylglutaconic aciduria (HP:0003535)3.22276510
22Elevated erythrocyte sedimentation rate (HP:0003565)3.20215144
23Acute encephalopathy (HP:0006846)3.19214411
24Abnormality of eosinophils (HP:0001879)3.14338319
25Progressive macrocephaly (HP:0004481)3.09481855
26Decreased activity of mitochondrial respiratory chain (HP:0008972)3.08241951
27Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.08241951
28Pancreatic cysts (HP:0001737)3.01354861
29Generalized aminoaciduria (HP:0002909)2.99460161
30Type I transferrin isoform profile (HP:0003642)2.98542642
31Renal cortical cysts (HP:0000803)2.94332678
32Congenital stationary night blindness (HP:0007642)2.93888594
33Stomatitis (HP:0010280)2.84347184
34Abnormality of T cell physiology (HP:0011840)2.82739667
35IgM deficiency (HP:0002850)2.80149268
36Increased serum lactate (HP:0002151)2.68241277
37Renal Fanconi syndrome (HP:0001994)2.62804724
38Abnormality of B cell number (HP:0010975)2.62758307
39Increased intramyocellular lipid droplets (HP:0012240)2.56902060
40B lymphocytopenia (HP:0010976)2.54134395
41Abnormal protein glycosylation (HP:0012346)2.51661364
42Abnormal glycosylation (HP:0012345)2.51661364
43Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.51661364
44Abnormal protein N-linked glycosylation (HP:0012347)2.51661364
45Cerebral edema (HP:0002181)2.49308037
46Abnormal albumin level (HP:0012116)2.48659433
47Hypoalbuminemia (HP:0003073)2.48659433
48Lactic acidosis (HP:0003128)2.47858689
49Eosinophilia (HP:0001880)2.46773905
50Aplasia/hypoplasia of the uterus (HP:0008684)2.40685325
51Absent rod-and cone-mediated responses on ERG (HP:0007688)2.40480710
52Abolished electroretinogram (ERG) (HP:0000550)2.38584224
53Abnormal delayed hypersensitivity skin test (HP:0002963)2.38204713
54Recurrent cutaneous fungal infections (HP:0011370)2.36070876
55Chronic mucocutaneous candidiasis (HP:0002728)2.36070876
56Abnormality of the prostate (HP:0008775)2.29848330
57Respiratory failure (HP:0002878)2.29240328
58Abnormality of the renal cortex (HP:0011035)2.27168730
59True hermaphroditism (HP:0010459)2.27152532
60Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.26188030
61Pancreatic fibrosis (HP:0100732)2.25212521
62Exertional dyspnea (HP:0002875)2.22214022
63Pustule (HP:0200039)2.22123522
64Pancytopenia (HP:0001876)2.20900696
65Increased muscle lipid content (HP:0009058)2.20766875
66Encephalitis (HP:0002383)2.20605454
67Hypothermia (HP:0002045)2.20438999
68Hyperalaninemia (HP:0003348)2.17080428
69Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.17080428
70Abnormality of alanine metabolism (HP:0010916)2.17080428
71Abnormal rod and cone electroretinograms (HP:0008323)2.16064259
72Molar tooth sign on MRI (HP:0002419)2.14948796
73Abnormality of midbrain morphology (HP:0002418)2.14948796
74Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.09229596
75Decreased electroretinogram (ERG) amplitude (HP:0000654)2.07103874
76Lethargy (HP:0001254)2.06550849
77Constricted visual fields (HP:0001133)2.04938027
78Autoimmune thrombocytopenia (HP:0001973)2.03894188
79Optic disc pallor (HP:0000543)2.03758668
80Leukocytosis (HP:0001974)2.02881490
81Dicarboxylic aciduria (HP:0003215)2.01816480
82Abnormality of dicarboxylic acid metabolism (HP:0010995)2.01816480
83Joint swelling (HP:0001386)1.98438391
84Recurrent bronchitis (HP:0002837)1.96481970
85Acute hepatic failure (HP:0006554)1.96462345
86Lymphopenia (HP:0001888)1.93805131
87Reduced antithrombin III activity (HP:0001976)1.92644218
88Attenuation of retinal blood vessels (HP:0007843)1.92527621
89Oral leukoplakia (HP:0002745)1.89350326
90Glycosuria (HP:0003076)1.89328606
91Abnormality of urine glucose concentration (HP:0011016)1.89328606
92Methylmalonic aciduria (HP:0012120)1.89203780
93CNS demyelination (HP:0007305)1.85840420
94Exercise intolerance (HP:0003546)1.85062655
95Lymphoma (HP:0002665)1.84489739
96Hypoplasia of the uterus (HP:0000013)1.82072416
97Granulocytopenia (HP:0001913)1.79182298
98Abnormality of cells of the lymphoid lineage (HP:0012140)1.78811669
99Polydipsia (HP:0001959)1.78059878
100Abnormal drinking behavior (HP:0030082)1.78059878

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.25418975
2KDR4.27656106
3TESK24.06906838
4MAP3K122.88253036
5TESK12.62446425
6TRIM282.60487346
7TAOK32.54900560
8ZAK2.45801594
9MST42.42443960
10MAP4K22.39727889
11LIMK12.32106023
12BCKDK2.31963841
13TLK12.25685649
14VRK22.09538343
15MAPKAPK31.84393588
16BUB11.83908750
17MAP4K11.81766148
18ITK1.74683365
19ADRBK21.66145012
20SCYL21.64617680
21BCR1.61033316
22SIK31.60219936
23VRK11.47135999
24MYLK1.41393553
25TIE11.36723081
26EIF2AK31.35955071
27DAPK11.33014161
28ERBB31.29793409
29SRPK11.27255135
30GRK11.22179883
31TEC1.18318498
32FES1.10367151
33CSNK1G31.10136345
34FRK1.01432563
35NEK11.00872209
36PINK10.96519302
37RPS6KA40.93156742
38NUAK10.93122113
39CSNK1A1L0.92094925
40SYK0.90873689
41CSNK1G10.85650478
42WNK40.84790747
43GRK60.80966060
44ZAP700.80683287
45CSNK1G20.80673974
46IKBKB0.79592008
47LCK0.79550501
48PDK20.78230051
49BMPR1B0.73109959
50IKBKE0.69671459
51WNK30.67231079
52LYN0.65419502
53RPS6KA50.65035038
54CSK0.64045330
55PRKCQ0.63463186
56BTK0.61929818
57KIT0.60343472
58INSRR0.58544283
59OXSR10.56715530
60JAK30.56522449
61TNK20.55553610
62MAP2K70.53801071
63EIF2AK10.52426449
64MAP3K110.51675787
65STK390.50492904
66TBK10.49202961
67IGF1R0.48701576
68GRK70.44987724
69PIK3CG0.44722229
70TAF10.42013982
71GRK50.38255586
72CAMKK20.37285400
73MUSK0.34914643
74JAK10.34599214
75MAP2K60.34448749
76EIF2AK20.32939434
77MINK10.31451006
78ABL10.31105442
79ROCK10.30468390
80PAK40.30213151
81CSNK1A10.30076271
82MATK0.29794851
83MAP2K20.29350927
84PAK30.29024163
85PRKCA0.28745098
86CSNK2A10.28729639
87AURKA0.26787587
88PLK30.26772264
89CLK10.26516455
90PRKCE0.25997045
91CAMK2A0.25547321
92TYK20.24905356
93PASK0.24745360
94PLK20.23042856
95PHKG20.22810061
96PHKG10.22810061
97FYN0.22289352
98PAK10.20809566
99EGFR0.20480651
100CSF1R0.20465471

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.73783633
2Primary immunodeficiency_Homo sapiens_hsa053404.51573629
3Oxidative phosphorylation_Homo sapiens_hsa001903.34768713
4Parkinsons disease_Homo sapiens_hsa050122.93163845
5Protein export_Homo sapiens_hsa030602.70854980
6Antigen processing and presentation_Homo sapiens_hsa046122.67163404
7Graft-versus-host disease_Homo sapiens_hsa053322.62783044
8Autoimmune thyroid disease_Homo sapiens_hsa053202.28351924
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.13624620
10Allograft rejection_Homo sapiens_hsa053302.13215914
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.05036822
12Hematopoietic cell lineage_Homo sapiens_hsa046401.89519135
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87788423
14Alzheimers disease_Homo sapiens_hsa050101.85267121
15Type I diabetes mellitus_Homo sapiens_hsa049401.82802645
16RNA polymerase_Homo sapiens_hsa030201.68413268
17Rheumatoid arthritis_Homo sapiens_hsa053231.67118920
18Huntingtons disease_Homo sapiens_hsa050161.59736923
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.56641870
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.56261943
21T cell receptor signaling pathway_Homo sapiens_hsa046601.55737227
22Caffeine metabolism_Homo sapiens_hsa002321.41490108
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.39528575
24Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.35913874
25Phototransduction_Homo sapiens_hsa047441.32761849
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25818187
27Homologous recombination_Homo sapiens_hsa034401.24486580
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.20831068
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.20400004
30Asthma_Homo sapiens_hsa053101.18758059
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.17963939
32Peroxisome_Homo sapiens_hsa041461.08749366
33Propanoate metabolism_Homo sapiens_hsa006401.07241556
34Regulation of autophagy_Homo sapiens_hsa041401.06787342
35Butanoate metabolism_Homo sapiens_hsa006501.06748096
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.05326106
37Cardiac muscle contraction_Homo sapiens_hsa042601.02415160
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01292162
39Shigellosis_Homo sapiens_hsa051311.00823975
40Non-homologous end-joining_Homo sapiens_hsa034500.96229671
41Measles_Homo sapiens_hsa051620.94647609
42Sulfur metabolism_Homo sapiens_hsa009200.94349725
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87780665
44RNA degradation_Homo sapiens_hsa030180.84959645
45Salmonella infection_Homo sapiens_hsa051320.84252724
46Collecting duct acid secretion_Homo sapiens_hsa049660.82746702
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81446981
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76765806
49Basal transcription factors_Homo sapiens_hsa030220.76643008
50Pyrimidine metabolism_Homo sapiens_hsa002400.74674358
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.72812284
52Fanconi anemia pathway_Homo sapiens_hsa034600.72357564
53Mismatch repair_Homo sapiens_hsa034300.72166136
54Viral myocarditis_Homo sapiens_hsa054160.71433691
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71182678
56Base excision repair_Homo sapiens_hsa034100.69295400
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68169542
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67514230
59Chemical carcinogenesis_Homo sapiens_hsa052040.67173145
60Retinol metabolism_Homo sapiens_hsa008300.67120429
61Linoleic acid metabolism_Homo sapiens_hsa005910.67009634
62DNA replication_Homo sapiens_hsa030300.66588427
63Nitrogen metabolism_Homo sapiens_hsa009100.66532531
64RNA transport_Homo sapiens_hsa030130.66149067
65Purine metabolism_Homo sapiens_hsa002300.60284928
66Spliceosome_Homo sapiens_hsa030400.55600799
67Tryptophan metabolism_Homo sapiens_hsa003800.54095679
68One carbon pool by folate_Homo sapiens_hsa006700.53743316
69Legionellosis_Homo sapiens_hsa051340.53277902
70Epstein-Barr virus infection_Homo sapiens_hsa051690.51843108
71Fatty acid elongation_Homo sapiens_hsa000620.51304382
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51034491
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50612861
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.49465986
75Systemic lupus erythematosus_Homo sapiens_hsa053220.49155108
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48956612
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48808507
78Herpes simplex infection_Homo sapiens_hsa051680.46937150
79Metabolic pathways_Homo sapiens_hsa011000.45671704
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45133534
81Nucleotide excision repair_Homo sapiens_hsa034200.44099740
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43192017
83Olfactory transduction_Homo sapiens_hsa047400.43014575
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.42643233
85Ribosome_Homo sapiens_hsa030100.42552791
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.41494479
87Selenocompound metabolism_Homo sapiens_hsa004500.38764441
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.38339680
89N-Glycan biosynthesis_Homo sapiens_hsa005100.38270708
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36375957
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36210908
92Folate biosynthesis_Homo sapiens_hsa007900.35590155
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35493637
94Malaria_Homo sapiens_hsa051440.35346797
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35326562
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.34188531
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33264818
98Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.31074535
99Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.28178512
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25116790

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