ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	water-soluble vitamin biosynthetic process (GO:0042364)	5.22776476
2	rRNA methylation (GO:0031167)	4.99729404
3	regulation of mitochondrial fission (GO:0090140)	4.93531907
4	DNA deamination (GO:0045006)	4.85632593
5	proteasome assembly (GO:0043248)	4.65621459
6	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.65047274
7	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.65047274
8	rRNA modification (GO:0000154)	4.64990326
9	GTP biosynthetic process (GO:0006183)	4.59744253
10	positive regulation of cell fate commitment (GO:0010455)	4.45047667
11	UTP biosynthetic process (GO:0006228)	4.24119413
12	fucose catabolic process (GO:0019317)	4.21769182
13	L-fucose metabolic process (GO:0042354)	4.21769182
14	L-fucose catabolic process (GO:0042355)	4.21769182
15	cullin deneddylation (GO:0010388)	4.14304660
16	positive regulation of mitochondrial fission (GO:0090141)	4.13455708
17	UTP metabolic process (GO:0046051)	4.09520123
18	negative regulation of synaptic transmission, GABAergic (GO:0032229)	4.06297943
19	head development (GO:0060322)	3.94610143
20	protein deneddylation (GO:0000338)	3.80847030
21	nucleobase biosynthetic process (GO:0046112)	3.60395493
22	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.59208773
23	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.59208773
24	NADH dehydrogenase complex assembly (GO:0010257)	3.59208773
25	protein polyglutamylation (GO:0018095)	3.57666058
26	maturation of 5.8S rRNA (GO:0000460)	3.54354607
27	positive regulation of T cell cytokine production (GO:0002726)	3.53569205
28	protein neddylation (GO:0045116)	3.50137296
29	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.39645545
30	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.34267732
31	guanosine-containing compound biosynthetic process (GO:1901070)	3.32647222
32	positive regulation of interleukin-8 secretion (GO:2000484)	3.32377536
33	histone H2A acetylation (GO:0043968)	3.32324488
34	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	3.29809283
35	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.27819551
36	transcription from mitochondrial promoter (GO:0006390)	3.27414908
37	DNA double-strand break processing (GO:0000729)	3.26652545
38	DNA catabolic process, exonucleolytic (GO:0000738)	3.22845007
39	regulation of vitamin D biosynthetic process (GO:0060556)	3.19272680
40	respiratory chain complex IV assembly (GO:0008535)	3.16097055
41	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.13343510
42	regulation of regulatory T cell differentiation (GO:0045589)	3.12852852
43	sleep (GO:0030431)	3.11603005
44	protein complex biogenesis (GO:0070271)	3.10900025
45	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	3.10304927
46	centriole replication (GO:0007099)	3.07290859
47	positive regulation of glycolytic process (GO:0045821)	3.04844760
48	ATP synthesis coupled proton transport (GO:0015986)	3.04258274
49	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.04258274
50	aggressive behavior (GO:0002118)	3.04070671
51	nucleoside diphosphate phosphorylation (GO:0006165)	3.03716094
52	morphogenesis of an endothelium (GO:0003159)	3.00191242
53	endothelial tube morphogenesis (GO:0061154)	3.00191242
54	artery smooth muscle contraction (GO:0014824)	2.99074225
55	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.98366177
56	iron-sulfur cluster assembly (GO:0016226)	2.97966707
57	metallo-sulfur cluster assembly (GO:0031163)	2.97966707
58	mitochondrial respiratory chain complex assembly (GO:0033108)	2.97515942
59	pyrimidine ribonucleoside metabolic process (GO:0046131)	2.95299152
60	C4-dicarboxylate transport (GO:0015740)	2.94019728
61	sequestering of actin monomers (GO:0042989)	2.93919433
62	cardiac left ventricle morphogenesis (GO:0003214)	2.93438805
63	pyrimidine ribonucleotide metabolic process (GO:0009218)	2.92125659
64	regulation of development, heterochronic (GO:0040034)	2.87831981
65	regulation of interleukin-8 secretion (GO:2000482)	2.87828857
66	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.87353015
67	regulation of timing of cell differentiation (GO:0048505)	2.86215947
68	serotonin receptor signaling pathway (GO:0007210)	2.84963119
69	CTP biosynthetic process (GO:0006241)	2.84564672
70	CTP metabolic process (GO:0046036)	2.84564672
71	endoderm formation (GO:0001706)	2.79502942
72	inositol phosphate-mediated signaling (GO:0048016)	2.77915095
73	pyrimidine nucleotide biosynthetic process (GO:0006221)	2.74667810
74	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	2.72761251
75	UMP biosynthetic process (GO:0006222)	2.72761251
76	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	2.72761251
77	UMP metabolic process (GO:0046049)	2.72761251
78	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.72314907
79	ribosome assembly (GO:0042255)	2.71636044
80	protein-cofactor linkage (GO:0018065)	2.70217067
81	mitochondrial RNA metabolic process (GO:0000959)	2.69291500
82	response to pheromone (GO:0019236)	2.68778563
83	regulation of vitamin metabolic process (GO:0030656)	2.68618164
84	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.68567820
85	nucleotide transmembrane transport (GO:1901679)	2.68290960
86	peptidyl-histidine modification (GO:0018202)	2.66663545
87	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.65997374
88	platelet dense granule organization (GO:0060155)	2.64784451
89	C-terminal protein lipidation (GO:0006501)	2.63507584
90	positive regulation of immune response to tumor cell (GO:0002839)	2.61853425
91	regulation of immune response to tumor cell (GO:0002837)	2.61853425
92	regulation of response to tumor cell (GO:0002834)	2.61853425
93	positive regulation of response to tumor cell (GO:0002836)	2.61853425
94	regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)	2.60693865
95	response to gravity (GO:0009629)	2.58502895
96	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.58113920
97	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.57466551
98	cellular response to exogenous dsRNA (GO:0071360)	2.57339715
99	positive regulation of defense response to virus by host (GO:0002230)	2.55713387
100	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.53376933

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	4.14245570
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.12461654
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.99346496
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.68585356
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.55864836
6	ZNF274_21170338_ChIP-Seq_K562_Hela	3.42464637
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.28606473
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.11674314
9	ELK1_19687146_ChIP-ChIP_HELA_Human	3.01650792
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.85539591
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.77280976
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.40567037
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.33999903
14	EWS_26573619_Chip-Seq_HEK293_Human	2.33458037
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.15718302
16	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.11109086
17	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.10604846
18	VDR_22108803_ChIP-Seq_LS180_Human	2.07457667
19	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.99582021
20	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.92667888
21	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.92397379
22	FOXP3_21729870_ChIP-Seq_TREG_Human	1.89607199
23	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.87279075
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.80879571
25	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.77287350
26	DCP1A_22483619_ChIP-Seq_HELA_Human	1.74529020
27	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.72339175
28	ER_23166858_ChIP-Seq_MCF-7_Human	1.70547391
29	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.66347720
30	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.59303774
31	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.58160022
32	TAF15_26573619_Chip-Seq_HEK293_Human	1.57692901
33	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.55495796
34	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.55127980
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.53748053
36	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.52877377
37	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.50576868
38	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.49204522
39	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.47637182
40	SOX2_19829295_ChIP-Seq_ESCs_Human	1.43883262
41	NANOG_19829295_ChIP-Seq_ESCs_Human	1.43883262
42	P300_19829295_ChIP-Seq_ESCs_Human	1.42887458
43	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.40941370
44	MYC_18940864_ChIP-ChIP_HL60_Human	1.39809796
45	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.39319304
46	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.39109411
47	GABP_19822575_ChIP-Seq_HepG2_Human	1.35821525
48	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.34723718
49	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.33874906
50	FUS_26573619_Chip-Seq_HEK293_Human	1.33394378
51	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.32999449
52	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.32392308
53	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.31268790
54	GATA3_26560356_Chip-Seq_TH2_Human	1.27164944
55	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.25653036
56	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.23291652
57	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.16702826
58	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.14765144
59	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.12943249
60	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.12192488
61	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.12111160
62	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.12111160
63	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.11728924
64	AR_20517297_ChIP-Seq_VCAP_Human	1.11464805
65	TTF2_22483619_ChIP-Seq_HELA_Human	1.10985859
66	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.09681405
67	TP53_22573176_ChIP-Seq_HFKS_Human	1.05493260
68	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.05312615
69	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.05095370
70	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.04777006
71	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.03186286
72	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.03179509
73	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.01508065
74	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.00268555
75	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.99558263
76	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.98995804
77	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.97225391
78	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.95452231
79	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.93749660
80	IRF1_19129219_ChIP-ChIP_H3396_Human	0.93451565
81	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.93006072
82	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.92828796
83	CBP_20019798_ChIP-Seq_JUKART_Human	0.92828796
84	BCAT_22108803_ChIP-Seq_LS180_Human	0.91504483
85	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.91479988
86	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.90675856
87	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.90243353
88	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.89803592
89	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.89722606
90	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.87613238
91	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.87521109
92	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.86829999
93	ELF5_23300383_ChIP-Seq_T47D_Human	0.86391549
94	NCOR_22424771_ChIP-Seq_293T_Human	0.86231726
95	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.85044843
96	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.84404293
97	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.84228613
98	RNF2_27304074_Chip-Seq_NSC_Mouse	0.83296593
99	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.83151794
100	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.82301917

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	5.84285555
2	MP0002138_abnormal_hepatobiliary_system	4.72655184
3	MP0005084_abnormal_gallbladder_morpholo	4.35505687
4	MP0000372_irregular_coat_pigmentation	3.95170968
5	MP0000569_abnormal_digit_pigmentation	3.89362695
6	MP0006054_spinal_hemorrhage	3.45308369
7	MP0008058_abnormal_DNA_repair	2.71179423
8	MP0003183_abnormal_peptide_metabolism	2.52920530
9	MP0005075_abnormal_melanosome_morpholog	2.39245263
10	MP0001485_abnormal_pinna_reflex	2.35563553
11	MP0005167_abnormal_blood-brain_barrier	2.19144187
12	MP0004885_abnormal_endolymph	2.10389477
13	MP0002234_abnormal_pharynx_morphology	1.95057351
14	MP0003567_abnormal_fetal_cardiomyocyte	1.88825690
15	MP0003724_increased_susceptibility_to	1.83345765
16	MP0003303_peritoneal_inflammation	1.83082696
17	MP0002148_abnormal_hypersensitivity_rea	1.64137692
18	MP0004742_abnormal_vestibular_system	1.62675934
19	MP0001984_abnormal_olfaction	1.58865119
20	MP0005671_abnormal_response_to	1.58677879
21	MP0000049_abnormal_middle_ear	1.52146246
22	MP0001879_abnormal_lymphatic_vessel	1.49289727
23	MP0003693_abnormal_embryo_hatching	1.48806102
24	MP0006276_abnormal_autonomic_nervous	1.48790235
25	MP0000427_abnormal_hair_cycle	1.47945388
26	MP0002938_white_spotting	1.46907014
27	MP0008877_abnormal_DNA_methylation	1.42693201
28	MP0005551_abnormal_eye_electrophysiolog	1.39258168
29	MP0009780_abnormal_chondrocyte_physiolo	1.34029692
30	MP0002736_abnormal_nociception_after	1.30720986
31	MP0006072_abnormal_retinal_apoptosis	1.29786711
32	MP0001873_stomach_inflammation	1.27223126
33	MP0008875_abnormal_xenobiotic_pharmacok	1.25190622
34	MP0001486_abnormal_startle_reflex	1.24587707
35	MP0003786_premature_aging	1.24138765
36	MP0000383_abnormal_hair_follicle	1.23960830
37	MP0005387_immune_system_phenotype	1.23844453
38	MP0001790_abnormal_immune_system	1.23844453
39	MP0004381_abnormal_hair_follicle	1.21448736
40	MP0010368_abnormal_lymphatic_system	1.21425420
41	MP0003011_delayed_dark_adaptation	1.21254719
42	MP0004147_increased_porphyrin_level	1.19814297
43	MP0005083_abnormal_biliary_tract	1.18678597
44	MP0006082_CNS_inflammation	1.15021198
45	MP0008789_abnormal_olfactory_epithelium	1.13552595
46	MP0002098_abnormal_vibrissa_morphology	1.12929157
47	MP0002876_abnormal_thyroid_physiology	1.06290006
48	MP0005499_abnormal_olfactory_system	1.04222436
49	MP0005394_taste/olfaction_phenotype	1.04222436
50	MP0002751_abnormal_autonomic_nervous	1.01865846
51	MP0001800_abnormal_humoral_immune	1.00664786
52	MP0005408_hypopigmentation	0.99514176
53	MP0003172_abnormal_lysosome_physiology	0.99506947
54	MP0001968_abnormal_touch/_nociception	0.98694935
55	MP0002282_abnormal_trachea_morphology	0.96413464
56	MP0005085_abnormal_gallbladder_physiolo	0.94913875
57	MP0003718_maternal_effect	0.93601693
58	MP0003938_abnormal_ear_development	0.93312015
59	MP0001986_abnormal_taste_sensitivity	0.90717342
60	MP0005365_abnormal_bile_salt	0.88070297
61	MP0000613_abnormal_salivary_gland	0.85649967
62	MP0004142_abnormal_muscle_tone	0.85546046
63	MP0000230_abnormal_systemic_arterial	0.84425077
64	MP0008872_abnormal_physiological_respon	0.83873760
65	MP0001191_abnormal_skin_condition	0.81610524
66	MP0002163_abnormal_gland_morphology	0.81454650
67	MP0005595_abnormal_vascular_smooth	0.79521421
68	MP0004782_abnormal_surfactant_physiolog	0.78747010
69	MP0002254_reproductive_system_inflammat	0.76938789
70	MP0002723_abnormal_immune_serum	0.75035485
71	MP0006292_abnormal_olfactory_placode	0.73970181
72	MP0001919_abnormal_reproductive_system	0.73553281
73	MP0008004_abnormal_stomach_pH	0.72850142
74	MP0001663_abnormal_digestive_system	0.72768129
75	MP0002295_abnormal_pulmonary_circulatio	0.71886929
76	MP0005379_endocrine/exocrine_gland_phen	0.71794844
77	MP0000647_abnormal_sebaceous_gland	0.71790989
78	MP0005253_abnormal_eye_physiology	0.71473177
79	MP0005670_abnormal_white_adipose	0.70928545
80	MP0002928_abnormal_bile_duct	0.70280810
81	MP0009785_altered_susceptibility_to	0.70018921
82	MP0003878_abnormal_ear_physiology	0.69177385
83	MP0005377_hearing/vestibular/ear_phenot	0.69177385
84	MP0000685_abnormal_immune_system	0.69015880
85	MP0005464_abnormal_platelet_physiology	0.68968912
86	MP0009333_abnormal_splenocyte_physiolog	0.68241378
87	MP0010678_abnormal_skin_adnexa	0.67999861
88	MP0001501_abnormal_sleep_pattern	0.67770691
89	MP0002090_abnormal_vision	0.67729972
90	MP0001440_abnormal_grooming_behavior	0.67712262
91	MP0005332_abnormal_amino_acid	0.67611969
92	MP0000516_abnormal_urinary_system	0.65237500
93	MP0005367_renal/urinary_system_phenotyp	0.65237500
94	MP0001835_abnormal_antigen_presentation	0.64893833
95	MP0009765_abnormal_xenobiotic_induced	0.63866793
96	MP0009046_muscle_twitch	0.62212489
97	MP0004084_abnormal_cardiac_muscle	0.62131873
98	MP0005636_abnormal_mineral_homeostasis	0.62085338
99	MP0004215_abnormal_myocardial_fiber	0.62029968
100	MP0008775_abnormal_heart_ventricle	0.61667294

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperglycinemia (HP:0002154)	3.61509431
2	Renal cortical cysts (HP:0000803)	3.42129644
3	Acute necrotizing encephalopathy (HP:0006965)	3.41094644
4	Molar tooth sign on MRI (HP:0002419)	3.38842913
5	Abnormality of midbrain morphology (HP:0002418)	3.38842913
6	Abnormality of the renal cortex (HP:0011035)	3.37327523
7	Methylmalonic acidemia (HP:0002912)	3.34911474
8	Increased CSF lactate (HP:0002490)	3.27026291
9	Nephronophthisis (HP:0000090)	3.26146786
10	Bile duct proliferation (HP:0001408)	3.20214425
11	Abnormal biliary tract physiology (HP:0012439)	3.20214425
12	Mitochondrial inheritance (HP:0001427)	3.18231114
13	Pancreatic cysts (HP:0001737)	3.12317955
14	Acute encephalopathy (HP:0006846)	3.08408755
15	Hepatocellular necrosis (HP:0001404)	3.02161102
16	Progressive macrocephaly (HP:0004481)	2.98240023
17	Dyschromatopsia (HP:0007641)	2.91819709
18	Adactyly (HP:0009776)	2.91464840
19	Pancreatic fibrosis (HP:0100732)	2.88121724
20	Abnormal mitochondria in muscle tissue (HP:0008316)	2.87967761
21	Intestinal atresia (HP:0011100)	2.79649249
22	Lipid accumulation in hepatocytes (HP:0006561)	2.78694959
23	Increased hepatocellular lipid droplets (HP:0006565)	2.76067841
24	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.73438939
25	Hepatic necrosis (HP:0002605)	2.70107151
26	Abnormality of the renal medulla (HP:0100957)	2.69672730
27	Conical tooth (HP:0000698)	2.65576469
28	IgG deficiency (HP:0004315)	2.61489092
29	Methylmalonic aciduria (HP:0012120)	2.58914338
30	Stomatitis (HP:0010280)	2.55610910
31	Increased IgM level (HP:0003496)	2.54521437
32	Increased serum pyruvate (HP:0003542)	2.54500448
33	Pancytopenia (HP:0001876)	2.49786791
34	Cerebral edema (HP:0002181)	2.49237338
35	3-Methylglutaconic aciduria (HP:0003535)	2.48713477
36	Abnormality of the labia minora (HP:0012880)	2.45559079
37	Tubular atrophy (HP:0000092)	2.45532763
38	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.44540045
39	Supernumerary bones of the axial skeleton (HP:0009144)	2.43927662
40	True hermaphroditism (HP:0010459)	2.38725585
41	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.37188911
42	Disproportionate short-trunk short stature (HP:0003521)	2.36317687
43	Abolished electroretinogram (ERG) (HP:0000550)	2.33580793
44	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.32940349
45	B lymphocytopenia (HP:0010976)	2.30011078
46	Abnormality of the costochondral junction (HP:0000919)	2.29565237
47	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.26142739
48	Abnormality of alanine metabolism (HP:0010916)	2.25881090
49	Hyperalaninemia (HP:0003348)	2.25881090
50	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.25881090
51	Aplasia/Hypoplasia of the ulna (HP:0006495)	2.25488153
52	Renal Fanconi syndrome (HP:0001994)	2.23483664
53	Reduced antithrombin III activity (HP:0001976)	2.23471773
54	Abnormality of the ileum (HP:0001549)	2.23114195
55	Abnormality of B cell number (HP:0010975)	2.22482916
56	Cleft eyelid (HP:0000625)	2.21966912
57	Abnormality of serum amino acid levels (HP:0003112)	2.21906902
58	Porencephaly (HP:0002132)	2.18410417
59	Increased serum lactate (HP:0002151)	2.18108293
60	Carpal bone hypoplasia (HP:0001498)	2.17921199
61	Hypoplasia of the ulna (HP:0003022)	2.15827359
62	Abnormality of serine family amino acid metabolism (HP:0010894)	2.13861669
63	Abnormality of glycine metabolism (HP:0010895)	2.13861669
64	Fibular aplasia (HP:0002990)	2.13430046
65	Abnormality of vitamin B metabolism (HP:0004340)	2.12055400
66	Absent/shortened dynein arms (HP:0200106)	2.11811856
67	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.11811856
68	Polydipsia (HP:0001959)	2.11626125
69	Abnormal drinking behavior (HP:0030082)	2.11626125
70	Stenosis of the external auditory canal (HP:0000402)	2.10941544
71	Meckel diverticulum (HP:0002245)	2.09145711
72	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.07748474
73	Progressive inability to walk (HP:0002505)	2.06853952
74	Megalencephaly (HP:0001355)	2.06464164
75	Abnormality of the anterior horn cell (HP:0006802)	2.06399913
76	Degeneration of anterior horn cells (HP:0002398)	2.06399913
77	Hypoplasia of the radius (HP:0002984)	2.05350408
78	Hypoproteinemia (HP:0003075)	2.02854655
79	Lethargy (HP:0001254)	2.00512637
80	CNS demyelination (HP:0007305)	1.96870062
81	Abnormality of glycolysis (HP:0004366)	1.94238596
82	Exertional dyspnea (HP:0002875)	1.92984445
83	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.92020287
84	Cupped ear (HP:0000378)	1.89988933
85	Forearm undergrowth (HP:0009821)	1.89314019
86	Abnormal protein glycosylation (HP:0012346)	1.86571938
87	Abnormal glycosylation (HP:0012345)	1.86571938
88	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.86571938
89	Abnormal protein N-linked glycosylation (HP:0012347)	1.86571938
90	Cerebral hypomyelination (HP:0006808)	1.83932012
91	Type I transferrin isoform profile (HP:0003642)	1.82560750
92	Amniotic constriction ring (HP:0009775)	1.82297641
93	Abnormality of placental membranes (HP:0011409)	1.82297641
94	Gastrointestinal atresia (HP:0002589)	1.80576347
95	Medial flaring of the eyebrow (HP:0010747)	1.80303474
96	Abnormal respiratory motile cilium morphology (HP:0005938)	1.79772821
97	Abnormal respiratory epithelium morphology (HP:0012253)	1.79772821
98	Optic disc pallor (HP:0000543)	1.78631242
99	Increased intramyocellular lipid droplets (HP:0012240)	1.78495420
100	Aqueductal stenosis (HP:0002410)	1.77259628

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.49726973
2	TIE1	4.26672397
3	TRIM28	4.13128674
4	BCR	3.51758785
5	MAP4K2	3.27741150
6	TSSK6	3.07581552
7	SIK3	3.03902838
8	MST4	2.86878342
9	MAP4K1	2.44926791
10	TLK1	2.41384311
11	SCYL2	2.38215577
12	SRPK1	2.33159755
13	GRK1	2.16081512
14	PINK1	1.93573008
15	MAP3K12	1.93211444
16	MINK1	1.81460508
17	NUAK1	1.79849034
18	TAF1	1.68794402
19	MAP3K9	1.63581970
20	MAPKAPK3	1.48939450
21	TEC	1.42789706
22	BMPR1B	1.36366437
23	INSRR	1.33361719
24	VRK2	1.32960945
25	NEK9	1.32846336
26	CSNK1A1L	1.24919974
27	PDK2	1.23717346
28	WNK3	1.17371185
29	NLK	1.13973179
30	DYRK2	1.10679015
31	TNIK	1.09148607
32	VRK1	1.09077294
33	CCNB1	1.08479135
34	CSNK1G1	1.05098430
35	BUB1	1.02130106
36	PBK	0.98445670
37	CSNK1G3	0.97798747
38	BCKDK	0.97608660
39	IKBKB	0.94928677
40	FER	0.94826089
41	IRAK2	0.94117410
42	RPS6KA4	0.91204288
43	PLK3	0.90092949
44	NEK1	0.87967699
45	IKBKE	0.85628204
46	CDK8	0.83848540
47	FES	0.82009466
48	FRK	0.79539866
49	ADRBK2	0.78955929
50	ZAK	0.77356120
51	FGFR2	0.76963396
52	DAPK1	0.75123708
53	RPS6KA5	0.74579662
54	TAOK3	0.68558593
55	CSNK1G2	0.67636969
56	MATK	0.64965556
57	IRAK1	0.63679031
58	DAPK2	0.61580140
59	PAK3	0.61180006
60	ITK	0.60525263
61	PLK2	0.59876456
62	ZAP70	0.57819019
63	MYLK	0.56397254
64	MAPK13	0.54172694
65	CASK	0.51990132
66	OXSR1	0.50155859
67	PIK3CG	0.48685931
68	PLK4	0.48168419
69	ERBB3	0.46952664
70	TBK1	0.46460222
71	CHUK	0.45395180
72	IGF1R	0.42009713
73	PTK2B	0.40195061
74	MAP2K6	0.38503738
75	MAP3K5	0.38465704
76	ADRBK1	0.38249645
77	ACVR1B	0.38111235
78	FGFR1	0.37567358
79	CSNK2A1	0.36261842
80	CAMKK2	0.35668598
81	CSNK1A1	0.31764648
82	PRKCE	0.30337128
83	NME1	0.29574366
84	BRSK2	0.29473876
85	TGFBR1	0.29036520
86	FLT3	0.28257173
87	CAMK2A	0.28003328
88	EIF2AK3	0.27259564
89	AURKB	0.25673929
90	HCK	0.24535447
91	WNK4	0.24025375
92	PHKG2	0.23978981
93	PHKG1	0.23978981
94	LYN	0.23303446
95	MAP2K1	0.20726404
96	KIT	0.19865055
97	FGR	0.19779291
98	RIPK4	0.19543244
99	LCK	0.18838938
100	CAMK1	0.18566457

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.81173304
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.36588476
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.87333059
4	Protein export_Homo sapiens_hsa03060	2.81776139
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.50497718
6	Basal transcription factors_Homo sapiens_hsa03022	2.49068336
7	Sulfur metabolism_Homo sapiens_hsa00920	2.34661418
8	RNA degradation_Homo sapiens_hsa03018	2.30180467
9	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.28226974
10	Parkinsons disease_Homo sapiens_hsa05012	2.19041595
11	Non-homologous end-joining_Homo sapiens_hsa03450	2.18504518
12	Propanoate metabolism_Homo sapiens_hsa00640	1.98905824
13	Phototransduction_Homo sapiens_hsa04744	1.88446301
14	Allograft rejection_Homo sapiens_hsa05330	1.88309416
15	RNA transport_Homo sapiens_hsa03013	1.82846400
16	RNA polymerase_Homo sapiens_hsa03020	1.76758671
17	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.67375924
18	Collecting duct acid secretion_Homo sapiens_hsa04966	1.66391495
19	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.54801103
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.52306121
21	Asthma_Homo sapiens_hsa05310	1.48258302
22	Huntingtons disease_Homo sapiens_hsa05016	1.46015538
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.45731892
24	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.43313811
25	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.36429395
26	Spliceosome_Homo sapiens_hsa03040	1.35757359
27	Steroid biosynthesis_Homo sapiens_hsa00100	1.35202624
28	Nucleotide excision repair_Homo sapiens_hsa03420	1.31989224
29	Pyruvate metabolism_Homo sapiens_hsa00620	1.29890488
30	Rheumatoid arthritis_Homo sapiens_hsa05323	1.29852930
31	Mismatch repair_Homo sapiens_hsa03430	1.28545577
32	Homologous recombination_Homo sapiens_hsa03440	1.26703780
33	Type I diabetes mellitus_Homo sapiens_hsa04940	1.25853224
34	Graft-versus-host disease_Homo sapiens_hsa05332	1.25757075
35	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.22478451
36	Alzheimers disease_Homo sapiens_hsa05010	1.22036772
37	One carbon pool by folate_Homo sapiens_hsa00670	1.21608953
38	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.18965628
39	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.17714302
40	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.08898817
41	Fatty acid elongation_Homo sapiens_hsa00062	1.07132011
42	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.07060447
43	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.06858032
44	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.06629329
45	Tryptophan metabolism_Homo sapiens_hsa00380	1.05045602
46	Pyrimidine metabolism_Homo sapiens_hsa00240	1.03478149
47	Linoleic acid metabolism_Homo sapiens_hsa00591	1.00944309
48	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.99816838
49	Purine metabolism_Homo sapiens_hsa00230	0.98342192
50	Butanoate metabolism_Homo sapiens_hsa00650	0.94804230
51	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.94583130
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.87902863
53	Glutathione metabolism_Homo sapiens_hsa00480	0.86204595
54	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.84802090
55	Peroxisome_Homo sapiens_hsa04146	0.84639349
56	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.82698037
57	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.81696211
58	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.75491954
59	Regulation of autophagy_Homo sapiens_hsa04140	0.72202981
60	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.70595670
61	Selenocompound metabolism_Homo sapiens_hsa00450	0.69967037
62	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.68605442
63	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.68402349
64	mRNA surveillance pathway_Homo sapiens_hsa03015	0.68387663
65	beta-Alanine metabolism_Homo sapiens_hsa00410	0.67603949
66	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.67440377
67	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.65883394
68	Antigen processing and presentation_Homo sapiens_hsa04612	0.64296696
69	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.62992710
70	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.61144290
71	Fatty acid metabolism_Homo sapiens_hsa01212	0.60116253
72	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.59611389
73	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.59561874
74	Cardiac muscle contraction_Homo sapiens_hsa04260	0.59082562
75	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.58381219
76	Legionellosis_Homo sapiens_hsa05134	0.57487053
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.54966757
78	Metabolic pathways_Homo sapiens_hsa01100	0.54918355
79	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.53556047
80	African trypanosomiasis_Homo sapiens_hsa05143	0.53445407
81	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.53156073
82	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.52841656
83	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.51961306
84	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.51479702
85	Primary immunodeficiency_Homo sapiens_hsa05340	0.51443630
86	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.49096783
87	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.48890061
88	Caffeine metabolism_Homo sapiens_hsa00232	0.48734499
89	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.46530607
90	Renin-angiotensin system_Homo sapiens_hsa04614	0.42178091
91	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.42148187
92	Fat digestion and absorption_Homo sapiens_hsa04975	0.41118615
93	Ether lipid metabolism_Homo sapiens_hsa00565	0.36788348
94	Serotonergic synapse_Homo sapiens_hsa04726	0.36270404
95	Glycerolipid metabolism_Homo sapiens_hsa00561	0.36086971
96	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.35398955
97	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.34880475
98	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.34773079
99	Vibrio cholerae infection_Homo sapiens_hsa05110	0.34052772
100	Retinol metabolism_Homo sapiens_hsa00830	0.33352799

YWHAZP7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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