YY1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1heterochromatin organization (GO:0070828)6.69768042
2DNA unwinding involved in DNA replication (GO:0006268)5.55625279
3protein localization to kinetochore (GO:0034501)5.47752630
4chromatin assembly (GO:0031497)4.93014776
5mitotic sister chromatid cohesion (GO:0007064)4.86697276
6mitotic sister chromatid segregation (GO:0000070)4.48320762
7protein localization to chromosome, centromeric region (GO:0071459)4.33922356
8daunorubicin metabolic process (GO:0044597)4.21922708
9polyketide metabolic process (GO:0030638)4.21922708
10doxorubicin metabolic process (GO:0044598)4.21922708
11negative regulation of gene silencing (GO:0060969)4.17154895
12trophectodermal cell differentiation (GO:0001829)4.16398177
13nuclear pore complex assembly (GO:0051292)4.15962872
14muscle organ morphogenesis (GO:0048644)4.15783854
15pre-miRNA processing (GO:0031054)4.11153058
16sister chromatid segregation (GO:0000819)4.05595152
17formation of translation preinitiation complex (GO:0001731)4.04748432
18negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.03770041
19histone H4-K12 acetylation (GO:0043983)3.99939328
20regulation of DNA endoreduplication (GO:0032875)3.98274077
21regulation of nuclear cell cycle DNA replication (GO:0033262)3.90888307
22nuclear pore organization (GO:0006999)3.89431111
23ribosomal small subunit biogenesis (GO:0042274)3.83762212
24regulation of posttranscriptional gene silencing (GO:0060147)3.81657242
25regulation of gene silencing by miRNA (GO:0060964)3.81657242
26regulation of gene silencing by RNA (GO:0060966)3.81657242
27DNA duplex unwinding (GO:0032508)3.76443052
28DNA deamination (GO:0045006)3.75365739
29regulation of chromatin binding (GO:0035561)3.74626028
30negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.73252561
31rRNA transcription (GO:0009303)3.72965841
32DNA replication initiation (GO:0006270)3.71589099
33DNA geometric change (GO:0032392)3.70519750
34DNA topological change (GO:0006265)3.66432542
35regulation of RNA export from nucleus (GO:0046831)3.62147506
36negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.60479796
37DNA replication-dependent nucleosome assembly (GO:0006335)3.59226145
38DNA replication-dependent nucleosome organization (GO:0034723)3.59226145
39CENP-A containing nucleosome assembly (GO:0034080)3.58097498
40maternal placenta development (GO:0001893)3.56812948
41chromatin remodeling at centromere (GO:0031055)3.54865727
42negative regulation of cell cycle G2/M phase transition (GO:1902750)3.54690663
43regulation of mammary gland epithelial cell proliferation (GO:0033599)3.51976251
44regulation of telomere maintenance via telomerase (GO:0032210)3.51856572
45DNA replication checkpoint (GO:0000076)3.51800564
46RNA stabilization (GO:0043489)3.51427966
47mRNA stabilization (GO:0048255)3.51427966
48regulation of gene silencing (GO:0060968)3.44088969
49regulation of chromatin silencing (GO:0031935)3.40195985
50negative regulation of epidermis development (GO:0045683)3.38923200
51regulation of retinoic acid receptor signaling pathway (GO:0048385)3.37873131
52mitotic chromosome condensation (GO:0007076)3.34788109
53regulation of hippo signaling (GO:0035330)3.32618835
54maintenance of protein location in nucleus (GO:0051457)3.31727821
55histone H4-K5 acetylation (GO:0043981)3.28125505
56histone H4-K8 acetylation (GO:0043982)3.28125505
57regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.28119106
58negative regulation of telomerase activity (GO:0051974)3.27577816
59mitotic nuclear envelope disassembly (GO:0007077)3.25613543
60pseudouridine synthesis (GO:0001522)3.22775051
61alternative mRNA splicing, via spliceosome (GO:0000380)3.22581958
62DNA synthesis involved in DNA repair (GO:0000731)3.20492625
63folic acid-containing compound biosynthetic process (GO:0009396)3.20048240
64intestinal epithelial cell development (GO:0060576)3.20039960
65ribosome biogenesis (GO:0042254)3.18845607
66negative regulation of RNA splicing (GO:0033119)3.17496082
67DNA strand elongation involved in DNA replication (GO:0006271)3.16396641
68positive regulation of protein deacetylation (GO:0090312)3.16166804
69DNA strand elongation (GO:0022616)3.14719216
70nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.14227241
71intracellular estrogen receptor signaling pathway (GO:0030520)3.11225626
72positive regulation of gene expression, epigenetic (GO:0045815)3.09774744
73cellular senescence (GO:0090398)3.09705895
74negative regulation of mRNA metabolic process (GO:1903312)3.09418939
75nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.08908536
76somite rostral/caudal axis specification (GO:0032525)3.07430805
77pore complex assembly (GO:0046931)3.06696520
78membrane disassembly (GO:0030397)3.05115795
79nuclear envelope disassembly (GO:0051081)3.05115795
80regulation of translation in response to stress (GO:0043555)3.04428790
81maturation of SSU-rRNA (GO:0030490)3.03463047
82DNA replication-independent nucleosome organization (GO:0034724)3.01578505
83DNA replication-independent nucleosome assembly (GO:0006336)3.01578505
84ribonucleoprotein complex biogenesis (GO:0022613)3.01440117
85intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.97037432
86translational initiation (GO:0006413)2.96033085
87translational elongation (GO:0006414)2.95461651
88embryonic process involved in female pregnancy (GO:0060136)2.95089353
89branching involved in mammary gland duct morphogenesis (GO:0060444)2.95002197
90negative regulation of DNA repair (GO:0045738)2.94357790
91NLS-bearing protein import into nucleus (GO:0006607)2.93602046
92positive regulation of chromosome segregation (GO:0051984)2.93170462
93histone phosphorylation (GO:0016572)2.92445035
94DNA conformation change (GO:0071103)2.92090773
95ATP-dependent chromatin remodeling (GO:0043044)2.91065019
96pteridine-containing compound biosynthetic process (GO:0042559)2.89931311
97regulation of nucleobase-containing compound transport (GO:0032239)2.88908551
98histone exchange (GO:0043486)2.88685753
99positive regulation of DNA-dependent DNA replication (GO:2000105)2.88476864
100establishment of integrated proviral latency (GO:0075713)2.87037292
101negative regulation of histone methylation (GO:0031061)2.86313738
102regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.85310914
103positive regulation of histone deacetylation (GO:0031065)2.84171275
104negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.83081288
105positive regulation by host of viral transcription (GO:0043923)2.82197912
106regulation of histone methylation (GO:0031060)2.81668433
107N-terminal protein amino acid acetylation (GO:0006474)2.80507558
108embryonic placenta development (GO:0001892)2.79708436
109V(D)J recombination (GO:0033151)2.77549583
110chromatin assembly or disassembly (GO:0006333)2.77492053
111spindle assembly involved in mitosis (GO:0090307)2.76317964
112viral transcription (GO:0019083)2.76260711
113kinetochore organization (GO:0051383)2.74220089
114regulation of DNA-dependent DNA replication (GO:0090329)2.73169549
115regulation of response to osmotic stress (GO:0047484)2.72745431
116protein complex localization (GO:0031503)2.71575521
117mitotic metaphase plate congression (GO:0007080)2.69899832
118protein localization to chromosome (GO:0034502)2.69688377
119regulation of G0 to G1 transition (GO:0070316)2.69467932
120negative regulation of erythrocyte differentiation (GO:0045647)2.69286518
121sister chromatid cohesion (GO:0007062)2.69224837
122spindle assembly (GO:0051225)2.69085281
123nucleosome disassembly (GO:0006337)2.68471473
124protein-DNA complex disassembly (GO:0032986)2.68471473
125DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.66962760
126telomere maintenance via semi-conservative replication (GO:0032201)2.66807461
127regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.66407671
128primitive streak formation (GO:0090009)2.66182878
129translational termination (GO:0006415)2.65829939
130establishment of apical/basal cell polarity (GO:0035089)2.64978078
131rRNA processing (GO:0006364)2.64740763
132termination of RNA polymerase II transcription (GO:0006369)2.63833785
133positive regulation of DNA-templated transcription, initiation (GO:2000144)2.63730322
134histone H4-K16 acetylation (GO:0043984)2.63596250
135chromosome condensation (GO:0030261)2.63140522
136interferon-gamma secretion (GO:0072643)2.63021168
137negative regulation of mRNA processing (GO:0050686)2.62752456
138histone H3-K36 demethylation (GO:0070544)2.62711184
139regulation of histone H3-K9 methylation (GO:0051570)2.62194419
140viral life cycle (GO:0019058)2.61737302
141maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.61578707
142rRNA metabolic process (GO:0016072)2.58949706
143positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.57678836
144monoubiquitinated protein deubiquitination (GO:0035520)2.55661450
145positive regulation of histone H3-K4 methylation (GO:0051571)2.55473459
146positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.53687263
147positive regulation of mitotic sister chromatid separation (GO:1901970)2.53687263
148positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.53687263
149metaphase plate congression (GO:0051310)2.53188398
150ribosomal small subunit assembly (GO:0000028)2.52147626
151cellular protein complex disassembly (GO:0043624)2.52144853
152regulation of histone H3-K27 methylation (GO:0061085)2.52131992
153regulation of translational fidelity (GO:0006450)2.51174121
154mitotic recombination (GO:0006312)2.50556497
155DNA packaging (GO:0006323)2.50463221

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.11127335
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.85266152
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.85266152
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.85266152
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.35870899
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.73038087
7* MYC_18555785_ChIP-Seq_MESCs_Mouse2.69604435
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.65557154
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.64059955
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.56398917
11MYC_22102868_ChIP-Seq_BL_Human2.49829929
12POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.44127093
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.41483195
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.34416997
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.28204917
16NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.25324081
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.24809161
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.09956839
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.03186496
20TP63_19390658_ChIP-ChIP_HaCaT_Human2.00223128
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.96077834
22STAT3_1855785_ChIP-Seq_MESCs_Mouse1.95584094
23TCF3_18692474_ChIP-Seq_MEFs_Mouse1.93346991
24NANOG_18555785_ChIP-Seq_MESCs_Mouse1.91825887
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.90477325
26* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.89419943
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.88684302
28SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.82308146
29ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.80259707
30* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.78018257
31ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.76582898
32TTF2_22483619_ChIP-Seq_HELA_Human1.75641320
33KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.73971328
34VDR_21846776_ChIP-Seq_THP-1_Human1.69853876
35TCF3_18692474_ChIP-Seq_MESCs_Mouse1.69465359
36SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.67416643
37* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.66872503
38* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66543220
39NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.63272957
40* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.63192549
41SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.60216661
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49192272
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48100631
44* TCF7_22412390_ChIP-Seq_EML_Mouse1.47753020
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.45521496
46HIF1A_21447827_ChIP-Seq_MCF-7_Human1.43934475
47PKCTHETA_26484144_Chip-Seq_BREAST_Human1.43443670
48NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.42589624
49SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.41488400
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.41449434
51NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.41245615
52XRN2_22483619_ChIP-Seq_HELA_Human1.39067250
53* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35452636
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.30556575
55NELFA_20434984_ChIP-Seq_ESCs_Mouse1.29219031
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29010392
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28857761
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28770685
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27913475
60CREB1_15753290_ChIP-ChIP_HEK293T_Human1.26736248
61CHD1_26751641_Chip-Seq_LNCaP_Human1.26207980
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.26156650
63OCT4_18692474_ChIP-Seq_MEFs_Mouse1.25528520
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25132874
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.23892300
66NANOG_18692474_ChIP-Seq_MEFs_Mouse1.21829321
67POU5F1_16518401_ChIP-PET_MESCs_Mouse1.21703558
68* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.20846044
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20663576
70NANOG_21062744_ChIP-ChIP_HESCs_Human1.20624555
71* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18009103
72SOX2_18692474_ChIP-Seq_MEFs_Mouse1.17889528
73ZNF263_19887448_ChIP-Seq_K562_Human1.17325846
74* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.14879458
75NCOR1_26117541_ChIP-Seq_K562_Human1.13881516
76ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13547633
77TP63_17297297_ChIP-ChIP_HaCaT_Human1.13111900
78* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12848642
79E2F1_21310950_ChIP-Seq_MCF-7_Human1.12624359
80E2F1_18555785_ChIP-Seq_MESCs_Mouse1.11971049
81* KDM5A_27292631_Chip-Seq_BREAST_Human1.11925100
82ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11230891
83ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10904089
84YY1_21170310_ChIP-Seq_MESCs_Mouse1.10686365
85SOX2_18692474_ChIP-Seq_MESCs_Mouse1.10377334
86NANOG_18692474_ChIP-Seq_MESCs_Mouse1.10303737
87* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10303516
88* KDM2B_26808549_Chip-Seq_DND41_Human1.10043627
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09449062
90* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08589380
91FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.07869271
92POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.07689781
93ETS1_20019798_ChIP-Seq_JURKAT_Human1.07415312
94AR_21909140_ChIP-Seq_LNCAP_Human1.07385169
95EST1_17652178_ChIP-ChIP_JURKAT_Human1.07046359
96SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06923892
97* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05823075
98* CIITA_25753668_ChIP-Seq_RAJI_Human1.05243917
99* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04371519
100* RACK7_27058665_Chip-Seq_MCF-7_Human1.03009599
101KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03000818
102SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01920733
103PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01552424
104RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01354131
105FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00881297
106THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00429527
107KDM2B_26808549_Chip-Seq_JURKAT_Human0.99016751
108MAF_26560356_Chip-Seq_TH1_Human0.98705305
109* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.97756484
110* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96730665
111ATF3_27146783_Chip-Seq_COLON_Human0.96368533
112TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96101988
113ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95050236
114* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94248552
115NOTCH1_21737748_ChIP-Seq_TLL_Human0.94100726
116* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93927583
117KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93768521
118NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93534244
119HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93482633
120GATA1_26923725_Chip-Seq_HPCs_Mouse0.93417820
121ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92983456
122CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92424717
123TFEB_21752829_ChIP-Seq_HELA_Human0.92379871
124* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92367702
125WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90252704
126UTX_26944678_Chip-Seq_JUKART_Human0.89897189
127FOXP3_21729870_ChIP-Seq_TREG_Human0.89663851
128HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.87521111
129PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.87034229
130* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86969174
131DCP1A_22483619_ChIP-Seq_HELA_Human0.86916871
132* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.86750166
133VDR_24763502_ChIP-Seq_THP-1_Human0.84312063
134NANOG_16153702_ChIP-ChIP_HESCs_Human0.83927378
135* MYB_26560356_Chip-Seq_TH1_Human0.81731570
136GATA1_22025678_ChIP-Seq_K562_Human0.80654279
137HOXB4_20404135_ChIP-ChIP_EML_Mouse0.79309442

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.65485644
2MP0004957_abnormal_blastocyst_morpholog3.55365846
3MP0009379_abnormal_foot_pigmentation3.52392155
4MP0010352_gastrointestinal_tract_polyps3.46539863
5MP0003705_abnormal_hypodermis_morpholog3.20513302
6MP0003693_abnormal_embryo_hatching3.13017716
7MP0004264_abnormal_extraembryonic_tissu2.58131841
8MP0000537_abnormal_urethra_morphology2.57356728
9MP0002009_preneoplasia2.55130462
10MP0003111_abnormal_nucleus_morphology2.50454819
11MP0003077_abnormal_cell_cycle2.37598350
12MP0002396_abnormal_hematopoietic_system2.12648967
13MP0003890_abnormal_embryonic-extraembry2.10698726
14MP0001730_embryonic_growth_arrest2.10341472
15MP0001849_ear_inflammation2.08386068
16MP0005380_embryogenesis_phenotype2.08307964
17MP0001672_abnormal_embryogenesis/_devel2.08307964
18MP0010094_abnormal_chromosome_stability2.04353027
19MP0002088_abnormal_embryonic_growth/wei1.95750773
20MP0003984_embryonic_growth_retardation1.95222379
21* MP0000350_abnormal_cell_proliferation1.91623841
22MP0002086_abnormal_extraembryonic_tissu1.87771966
23MP0002254_reproductive_system_inflammat1.81585510
24MP0002249_abnormal_larynx_morphology1.79107450
25MP0005076_abnormal_cell_differentiation1.78880735
26MP0000490_abnormal_crypts_of1.75245425
27MP0002796_impaired_skin_barrier1.73895574
28MP0002653_abnormal_ependyma_morphology1.68106834
29MP0002084_abnormal_developmental_patter1.68007434
30* MP0002085_abnormal_embryonic_tissue1.64105909
31MP0000049_abnormal_middle_ear1.63778280
32MP0004197_abnormal_fetal_growth/weight/1.61724095
33MP0002160_abnormal_reproductive_system1.59367798
34MP0005409_darkened_coat_color1.59276029
35MP0003937_abnormal_limbs/digits/tail_de1.59163739
36* MP0001697_abnormal_embryo_size1.57013701
37MP0010307_abnormal_tumor_latency1.50711723
38MP0009278_abnormal_bone_marrow1.48529566
39MP0001545_abnormal_hematopoietic_system1.46683790
40MP0005397_hematopoietic_system_phenotyp1.46683790
41MP0003119_abnormal_digestive_system1.46569098
42MP0003942_abnormal_urinary_system1.46437946
43MP0001188_hyperpigmentation1.43838342
44MP0003123_paternal_imprinting1.42569449
45MP0003763_abnormal_thymus_physiology1.42029151
46MP0001293_anophthalmia1.39984952
47MP0002877_abnormal_melanocyte_morpholog1.39500623
48MP0003303_peritoneal_inflammation1.39224207
49* MP0002080_prenatal_lethality1.36693591
50MP0008877_abnormal_DNA_methylation1.35307530
51MP0010030_abnormal_orbit_morphology1.33989786
52MP0008932_abnormal_embryonic_tissue1.32379837
53MP0003011_delayed_dark_adaptation1.31984441
54MP0005023_abnormal_wound_healing1.31968315
55MP0004185_abnormal_adipocyte_glucose1.30349215
56MP0005666_abnormal_adipose_tissue1.30208820
57MP0008007_abnormal_cellular_replicative1.29261796
58MP0006292_abnormal_olfactory_placode1.27118629
59MP0003566_abnormal_cell_adhesion1.21998861
60MP0003567_abnormal_fetal_cardiomyocyte1.20402124
61MP0009672_abnormal_birth_weight1.17536815
62MP0005257_abnormal_intraocular_pressure1.16948491
63MP0005499_abnormal_olfactory_system1.15389481
64MP0005394_taste/olfaction_phenotype1.15389481
65MP0002092_abnormal_eye_morphology1.14074528
66MP0000383_abnormal_hair_follicle1.13836409
67MP0000313_abnormal_cell_death1.13567647
68MP0000516_abnormal_urinary_system1.13512630
69MP0005367_renal/urinary_system_phenotyp1.13512630
70MP0002019_abnormal_tumor_incidence1.12763063
71MP0009250_abnormal_appendicular_skeleto1.12110960
72MP0003828_pulmonary_edema1.10252960
73MP0003121_genomic_imprinting1.09345218
74MP0003300_gastrointestinal_ulcer1.07357175
75MP0005075_abnormal_melanosome_morpholog1.06927604
76MP0009333_abnormal_splenocyte_physiolog1.06922164
77MP0000678_abnormal_parathyroid_gland1.06305289
78MP0010234_abnormal_vibrissa_follicle1.03944311
79MP0002098_abnormal_vibrissa_morphology1.03847512
80MP0004858_abnormal_nervous_system1.03792853
81MP0000534_abnormal_ureter_morphology1.03767533
82MP0002210_abnormal_sex_determination1.03215017
83MP0003448_altered_tumor_morphology1.01836672
84MP0001286_abnormal_eye_development1.01570879
85MP0002138_abnormal_hepatobiliary_system1.01269618
86MP0010678_abnormal_skin_adnexa1.00954080
87MP0000631_abnormal_neuroendocrine_gland1.00760859
88MP0003936_abnormal_reproductive_system0.99461301
89MP0004782_abnormal_surfactant_physiolog0.99013860
90MP0002697_abnormal_eye_size0.97098353
91MP0003453_abnormal_keratinocyte_physiol0.96822094
92MP0008770_decreased_survivor_rate0.96717961
93MP0000858_altered_metastatic_potential0.96275815
94MP0002332_abnormal_exercise_endurance0.96146372
95MP0000627_abnormal_mammary_gland0.94914949
96* MP0009703_decreased_birth_body0.93963612
97MP0009053_abnormal_anal_canal0.93959153
98MP0003806_abnormal_nucleotide_metabolis0.92142622
99MP0002925_abnormal_cardiovascular_devel0.92126435
100MP0004808_abnormal_hematopoietic_stem0.89402562
101MP0001145_abnormal_male_reproductive0.89256225
102MP0000432_abnormal_head_morphology0.88318015
103MP0008961_abnormal_basal_metabolism0.88286304
104MP0005248_abnormal_Harderian_gland0.87929782
105MP0000477_abnormal_intestine_morphology0.87654005
106MP0001346_abnormal_lacrimal_gland0.87390665
107MP0002722_abnormal_immune_system0.86424585
108MP0002132_abnormal_respiratory_system0.86182971
109MP0010630_abnormal_cardiac_muscle0.85989008
110MP0005646_abnormal_pituitary_gland0.85405879
111MP0004133_heterotaxia0.84542495
112MP0003115_abnormal_respiratory_system0.83481644
113MP0000689_abnormal_spleen_morphology0.82877807
114MP0000703_abnormal_thymus_morphology0.82432533
115MP0003938_abnormal_ear_development0.82197869
116MP0004130_abnormal_muscle_cell0.81775467
117MP0000428_abnormal_craniofacial_morphol0.81109631
118MP0005389_reproductive_system_phenotype0.80795837
119MP0001340_abnormal_eyelid_morphology0.80470742
120MP0009697_abnormal_copulation0.80390562
121MP0003935_abnormal_craniofacial_develop0.80349988
122MP0008058_abnormal_DNA_repair0.80296178
123MP0000377_abnormal_hair_follicle0.78576523
124MP0002398_abnormal_bone_marrow0.78352299
125MP0003436_decreased_susceptibility_to0.77982531
126MP0004381_abnormal_hair_follicle0.77601458
127MP0006082_CNS_inflammation0.77376328
128MP0001661_extended_life_span0.76751414
129MP0005266_abnormal_metabolism0.76252393
130MP0003315_abnormal_perineum_morphology0.75911175
131MP0003755_abnormal_palate_morphology0.75858823
132MP0002111_abnormal_tail_morphology0.75657719
133MP0005670_abnormal_white_adipose0.75353310
134MP0003283_abnormal_digestive_organ0.75290490
135MP0002970_abnormal_white_adipose0.74342350
136MP0003941_abnormal_skin_development0.74051061
137MP0003699_abnormal_female_reproductive0.73543275
138MP0002405_respiratory_system_inflammati0.73052080
139MP0000733_abnormal_muscle_development0.72848192
140MP0005501_abnormal_skin_physiology0.72334682
141MP0000653_abnormal_sex_gland0.70895478
142MP0001348_abnormal_lacrimal_gland0.70798829
143MP0002116_abnormal_craniofacial_bone0.70316550
144MP0002932_abnormal_joint_morphology0.69305160
145MP0000750_abnormal_muscle_regeneration0.68793098
146MP0003786_premature_aging0.68583074

Predicted human phenotypes

RankGene SetZ-score
1Multiple enchondromatosis (HP:0005701)4.89164525
2Hypochromic microcytic anemia (HP:0004840)4.55925963
3Bilateral microphthalmos (HP:0007633)4.05412093
4Rib fusion (HP:0000902)4.03102403
5Stenosis of the external auditory canal (HP:0000402)3.89640364
6Ependymoma (HP:0002888)3.88648621
7Carpal bone hypoplasia (HP:0001498)3.56078031
8Aplastic anemia (HP:0001915)3.50252936
9Ectopic kidney (HP:0000086)3.39021852
10Abnormality of the lower motor neuron (HP:0002366)3.20928795
11Rhabdomyosarcoma (HP:0002859)3.17525672
12Hypochromic anemia (HP:0001931)3.11313169
13Large earlobe (HP:0009748)3.09998648
14Neoplasm of striated muscle (HP:0009728)3.02965172
15Trismus (HP:0000211)3.02850087
16Abnormality of cochlea (HP:0000375)2.98064758
17Oral leukoplakia (HP:0002745)2.96768807
18Hepatoblastoma (HP:0002884)2.91563947
19Abnormality of the renal collecting system (HP:0004742)2.89797401
20Rectovaginal fistula (HP:0000143)2.89130529
21Rectal fistula (HP:0100590)2.89130529
22Short humerus (HP:0005792)2.87904191
23Aplasia/hypoplasia of the humerus (HP:0006507)2.87100550
24Abnormal cartilage morphology (HP:0002763)2.83227351
25Astrocytoma (HP:0009592)2.77081971
26Abnormality of the astrocytes (HP:0100707)2.77081971
27Acute lymphatic leukemia (HP:0006721)2.76688861
28Abnormality of the nasal septum (HP:0000419)2.74551665
29Fused cervical vertebrae (HP:0002949)2.73899132
30Intestinal fistula (HP:0100819)2.73416350
31Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.73242920
32Short 1st metacarpal (HP:0010034)2.73242920
33Acute myeloid leukemia (HP:0004808)2.72492958
34High anterior hairline (HP:0009890)2.71551796
35Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.71197636
36Birth length less than 3rd percentile (HP:0003561)2.67141617
37Reticulocytopenia (HP:0001896)2.65452744
38Shawl scrotum (HP:0000049)2.64435971
39Selective tooth agenesis (HP:0001592)2.62862530
40Vaginal fistula (HP:0004320)2.62423270
41Impulsivity (HP:0100710)2.59904755
42Abnormality of cells of the erythroid lineage (HP:0012130)2.59602554
43Preauricular skin tag (HP:0000384)2.58982671
44Rough bone trabeculation (HP:0100670)2.55447616
45Skin tags (HP:0010609)2.47499110
46Ankyloglossia (HP:0010296)2.44000344
47Morphological abnormality of the middle ear (HP:0008609)2.38861246
48Abnormality of the distal phalanges of the toes (HP:0010182)2.38575033
49Urethral obstruction (HP:0000796)2.35487296
50Spinal muscular atrophy (HP:0007269)2.35384485
51Abnormality of the 1st metacarpal (HP:0010009)2.35315215
52Abnormality of chromosome segregation (HP:0002916)2.35121513
53Chromosomal breakage induced by crosslinking agents (HP:0003221)2.32253767
54Premature ovarian failure (HP:0008209)2.27615521
55Missing ribs (HP:0000921)2.27130853
56Chromsome breakage (HP:0040012)2.26467812
57Abnormality of the columella (HP:0009929)2.19550611
58Abnormality of chromosome stability (HP:0003220)2.17567811
59Progressive muscle weakness (HP:0003323)2.16044490
60Nephroblastoma (Wilms tumor) (HP:0002667)2.15150272
61Absent thumb (HP:0009777)2.15092425
62Short middle phalanx of the 5th finger (HP:0004220)2.14925038
63Ulnar bowing (HP:0003031)2.14390711
64Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.13054267
65Aplasia/Hypoplasia of the sternum (HP:0006714)2.12101392
66Genu recurvatum (HP:0002816)2.11403561
67Nasal polyposis (HP:0100582)2.10429465
68Achilles tendon contracture (HP:0001771)2.10334812
69Atresia of the external auditory canal (HP:0000413)2.08784021
70Abnormality of the phalanges of the hallux (HP:0010057)2.08511442
71Lip pit (HP:0100267)2.07487664
72Abnormal number of erythroid precursors (HP:0012131)2.06230970
73Adenoma sebaceum (HP:0009720)2.05418200
74Angiofibromas (HP:0010615)2.05418200
75Abnormality of the aortic arch (HP:0012303)2.05059554
76Combined immunodeficiency (HP:0005387)2.04933717
77Squamous cell carcinoma (HP:0002860)2.04214409
78Abnormality of the preputium (HP:0100587)2.03370023
79Tongue fasciculations (HP:0001308)2.03297896
80Vertebral fusion (HP:0002948)2.03256139
81Sandal gap (HP:0001852)2.03233550
82Rectal prolapse (HP:0002035)2.02780603
83Osteomalacia (HP:0002749)2.02699012
84Nasolacrimal duct obstruction (HP:0000579)2.02204892
85Abnormality of the proximal phalanges of the hand (HP:0009834)2.01214117
86Abnormality of the phalanges of the 5th finger (HP:0004213)2.00102585
87Pallor (HP:0000980)1.99240043
88Testicular atrophy (HP:0000029)1.98953531
89Horseshoe kidney (HP:0000085)1.98919406
90Abnormality of the incisor (HP:0000676)1.97000797
91Limb hypertonia (HP:0002509)1.96982283
92Abnormality of the Achilles tendon (HP:0005109)1.96955636
93Embryonal renal neoplasm (HP:0011794)1.96794646
94Absent radius (HP:0003974)1.96410907
95Short 5th finger (HP:0009237)1.96205056
96Diastasis recti (HP:0001540)1.94586143
97Abnormal pancreas size (HP:0012094)1.94030557
98Glossoptosis (HP:0000162)1.93684429
99Microretrognathia (HP:0000308)1.93444582
100Sparse eyelashes (HP:0000653)1.93064653
101Duplicated collecting system (HP:0000081)1.92575920
102Muscle fibrillation (HP:0010546)1.92570112
103Arteriovenous malformation (HP:0100026)1.92471015
104Spastic diplegia (HP:0001264)1.92246004
105Germ cell neoplasia (HP:0100728)1.91945627
106Pseudobulbar signs (HP:0002200)1.91764500
107Abnormal umbilical cord blood vessels (HP:0011403)1.91144426
108Single umbilical artery (HP:0001195)1.91144426
109Abnormality of the fetal cardiovascular system (HP:0010948)1.91144426
110Abnormality of DNA repair (HP:0003254)1.89730066
111Transposition of the great arteries (HP:0001669)1.89366199
112Abnormal connection of the cardiac segments (HP:0011545)1.89366199
113Abnormal ventriculo-arterial connection (HP:0011563)1.89366199
114Short phalanx of the thumb (HP:0009660)1.88263805
115Glioma (HP:0009733)1.87771491
116Meckel diverticulum (HP:0002245)1.86267076
117Increased connective tissue (HP:0009025)1.86219706
118Breast hypoplasia (HP:0003187)1.85670073
119Atrophy/Degeneration involving motor neurons (HP:0007373)1.85272496
120Abnormality of the salivary glands (HP:0010286)1.84437449
121Facial asymmetry (HP:0000324)1.84091681
122Deep philtrum (HP:0002002)1.84070072
123Vertebral clefting (HP:0008428)1.84005199
124Deep palmar crease (HP:0006191)1.83538435
125Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.83486153
126Broad palm (HP:0001169)1.83323385
127Abnormality of the anterior horn cell (HP:0006802)1.82624783
128Degeneration of anterior horn cells (HP:0002398)1.82624783
129Abnormality of the carotid arteries (HP:0005344)1.82299341
130Abnormality of the ileum (HP:0001549)1.81960820
131Aplasia/Hypoplasia of the sacrum (HP:0008517)1.81599595
132Distal lower limb amyotrophy (HP:0008944)1.81297284
133Abnormality of the parietal bone (HP:0002696)1.80634806
134Abnormal trabecular bone morphology (HP:0100671)1.80339746
135Proximal placement of thumb (HP:0009623)1.79452774
136Prominent nose (HP:0000448)1.79316795
137Increased nuchal translucency (HP:0010880)1.79144393
138Abnormal hemoglobin (HP:0011902)1.79060941
139Supernumerary ribs (HP:0005815)1.78625355
140Abnormality of the nasal mucosa (HP:0000433)1.78330195
141Abnormality of the fingertips (HP:0001211)1.77772235
142Cafe-au-lait spot (HP:0000957)1.77638488
143Ureteral duplication (HP:0000073)1.77255710
144Short hallux (HP:0010109)1.77094265
145Tracheoesophageal fistula (HP:0002575)1.77039909
146Abnormality of the lacrimal duct (HP:0011481)1.75815998
147Abnormality of the distal phalanx of the thumb (HP:0009617)1.75767253
148Macroorchidism (HP:0000053)1.75251134
149Absent forearm bone (HP:0003953)1.75196740
150Aplasia involving forearm bones (HP:0009822)1.75196740
151Concave nail (HP:0001598)1.74463228
152Deviation of the thumb (HP:0009603)1.74276588
153Amyotrophic lateral sclerosis (HP:0007354)1.74207613
154Morphological abnormality of the inner ear (HP:0011390)1.74181557
155Short thumb (HP:0009778)1.73384253
156Abnormal lung lobation (HP:0002101)1.73308514
157Curly hair (HP:0002212)1.72888739
158Small intestinal stenosis (HP:0012848)1.71795239
159Duodenal stenosis (HP:0100867)1.71795239
160Volvulus (HP:0002580)1.71627796
161Myelodysplasia (HP:0002863)1.71581356
162Cheilitis (HP:0100825)1.71553607
163Spinal cord lesions (HP:0100561)1.71356454
164Syringomyelia (HP:0003396)1.71356454
165Peritonitis (HP:0002586)1.71309264
166Abnormal number of incisors (HP:0011064)1.70874638
167Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.70766051
168Aplasia/Hypoplasia of the uvula (HP:0010293)1.69357794
169Aplasia/Hypoplasia of the hallux (HP:0008362)1.68817405
170Medulloblastoma (HP:0002885)1.66515171
171Renal duplication (HP:0000075)1.63889634
172Malignant gastrointestinal tract tumors (HP:0006749)1.62878610
173Gastrointestinal carcinoma (HP:0002672)1.62878610
174Sparse lateral eyebrow (HP:0005338)1.62871112
175Increased serum ferritin (HP:0003281)1.61998759
176Delayed puberty (HP:0000823)1.60459009

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.74279099
2ERN13.16357554
3GRK62.96375776
4STK102.75842885
5BRD42.58701528
6MAP3K102.47114931
7PNCK2.41538210
8MAP3K92.31174468
9TYRO32.30968153
10SMG12.24066869
11PRPF4B2.20859633
12TRIB32.13502843
13MATK2.11418200
14TTK2.04201359
15GRK51.95808706
16CDK71.95023549
17CSF1R1.90786104
18EPHA21.85262727
19DDR21.83661842
20SRPK11.80968609
21CDC71.77005411
22CDK191.74336221
23HIPK21.69076308
24EEF2K1.63467773
25NEK21.58637413
26ICK1.54155394
27ALK1.53193962
28TGFBR21.48450454
29MAP3K131.46563673
30PAK41.44923331
31NEK11.42459142
32SIK11.38483302
33CDK41.37206397
34PKN21.29840069
35AKT21.27901240
36PDGFRA1.27375774
37WEE11.26325808
38CSK1.26088682
39RPS6KB21.23841325
40MAP2K21.23610519
41TAF11.19527122
42* PLK11.18828550
43MTOR1.11531798
44CHEK21.11193902
45BRAF1.10535739
46TESK21.09700828
47CHEK11.08962954
48STK241.07883707
49MAP3K81.07697422
50PLK41.05731714
51DYRK31.04444198
52EIF2AK11.04296784
53MAP4K11.03400671
54BMX1.02378044
55PASK1.00729218
56CDK61.00332698
57CAMK40.99657984
58AKT30.94858065
59MAPK70.94496348
60PIM20.93932536
61KSR20.91614741
62BUB10.90210846
63CDK20.89965223
64CDK90.88627030
65PIM10.87883894
66GRK10.86717728
67* AURKB0.85967312
68CAMK1G0.82823364
69FGFR30.80880256
70CDK30.78937609
71NLK0.77959451
72LATS20.77562267
73ADRBK20.77550554
74DYRK1B0.77506622
75PRKG20.77399684
76ATM0.76643229
77STK30.75975826
78ZAK0.75149401
79SCYL20.74482990
80STK40.73159918
81BRSK20.72389592
82FLT30.71649728
83TAOK10.70692190
84RIPK10.70468873
85LRRK20.69258015
86SGK30.68731754
87RPS6KL10.66226588
88RPS6KC10.66226588
89MKNK10.64932689
90EIF2AK30.64780705
91MOS0.64715302
92BLK0.64277887
93MELK0.62768888
94STK38L0.62750683
95CSNK1E0.61430587
96WNK10.61322294
97AURKA0.59053668
98LATS10.58911750
99MARK30.57732660
100PAK20.57507698
101RPS6KA60.57283328
102ATR0.55714854
103EIF2AK20.55493322
104GSK3A0.55128522
105RPS6KA40.55063878
106RPS6KB10.54180764
107SGK20.54043255
108BTK0.52845681
109FGR0.51884876
110RAF10.50157698
111MAPK110.50074496
112MARK20.49580698
113CHUK0.48169486
114PAK10.46831116
115CLK10.46532935
116CDK10.45488334
117MAP2K30.45338926
118NME20.45155112
119PTK60.44951695
120DMPK0.44292455
121GSK3B0.43147745
122PLK30.42496513
123IKBKB0.42122444
124MAP3K70.41880880
125STK160.41640481
126CDK80.41338165
127PTK20.41296769
128TNIK0.40550323
129TEC0.40550115
130SIK20.40135520
131MAP3K10.40056730
132CSNK2A20.39757226
133MAPK10.38902977
134PDGFRB0.38696371
135NUAK10.37953835
136MAPK140.36777066
137ZAP700.34651841
138MKNK20.34546880
139PRKCI0.33700974
140RPS6KA10.33550443
141TLK10.32867507
142EGFR0.32154583
143PRKD20.31880541
144MAP3K30.31451631
145AKT10.31230865
146MAPKAPK20.31097869
147GRK70.31080522

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.92303306
2Vitamin B6 metabolism_Homo sapiens_hsa007503.17478049
3DNA replication_Homo sapiens_hsa030302.87534173
4RNA transport_Homo sapiens_hsa030132.54020376
5Ribosome_Homo sapiens_hsa030102.48362636
6Mismatch repair_Homo sapiens_hsa034302.39298116
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.31905947
8Spliceosome_Homo sapiens_hsa030402.20281053
9One carbon pool by folate_Homo sapiens_hsa006702.13020760
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.99639266
11Cell cycle_Homo sapiens_hsa041101.97510909
12Thyroid cancer_Homo sapiens_hsa052161.94774268
13Sulfur relay system_Homo sapiens_hsa041221.87974533
14Base excision repair_Homo sapiens_hsa034101.87477287
15mRNA surveillance pathway_Homo sapiens_hsa030151.79853440
16Dorso-ventral axis formation_Homo sapiens_hsa043201.73106608
17Fructose and mannose metabolism_Homo sapiens_hsa000511.64039830
18mTOR signaling pathway_Homo sapiens_hsa041501.62069194
19p53 signaling pathway_Homo sapiens_hsa041151.55305784
20Acute myeloid leukemia_Homo sapiens_hsa052211.43002546
21Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.42107681
22Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.40314504
23Bladder cancer_Homo sapiens_hsa052191.40287391
24Homologous recombination_Homo sapiens_hsa034401.38736306
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.33636154
26Folate biosynthesis_Homo sapiens_hsa007901.31348094
27RNA polymerase_Homo sapiens_hsa030201.28784827
28MicroRNAs in cancer_Homo sapiens_hsa052061.27631753
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.25763434
30Nucleotide excision repair_Homo sapiens_hsa034201.22671553
31Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.22458717
32RNA degradation_Homo sapiens_hsa030181.21909707
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.21806724
34Galactose metabolism_Homo sapiens_hsa000521.18002635
35Glioma_Homo sapiens_hsa052141.17360233
36Fanconi anemia pathway_Homo sapiens_hsa034601.17314914
37Melanoma_Homo sapiens_hsa052181.15676823
38Wnt signaling pathway_Homo sapiens_hsa043101.11886279
39Alcoholism_Homo sapiens_hsa050341.09704712
40Central carbon metabolism in cancer_Homo sapiens_hsa052301.09416929
41Oocyte meiosis_Homo sapiens_hsa041141.07693843
42Chronic myeloid leukemia_Homo sapiens_hsa052201.07223672
43ErbB signaling pathway_Homo sapiens_hsa040121.06772074
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06229131
45Lysine degradation_Homo sapiens_hsa003101.06119441
46Herpes simplex infection_Homo sapiens_hsa051681.05637112
47Small cell lung cancer_Homo sapiens_hsa052221.05579943
48Viral carcinogenesis_Homo sapiens_hsa052031.00533429
49Pentose phosphate pathway_Homo sapiens_hsa000301.00021249
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.99514974
51Biosynthesis of amino acids_Homo sapiens_hsa012300.93953785
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91997439
53Notch signaling pathway_Homo sapiens_hsa043300.91229155
54Non-small cell lung cancer_Homo sapiens_hsa052230.91143964
55Apoptosis_Homo sapiens_hsa042100.90885377
56FoxO signaling pathway_Homo sapiens_hsa040680.90554225
57Prolactin signaling pathway_Homo sapiens_hsa049170.88393520
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87846370
59Choline metabolism in cancer_Homo sapiens_hsa052310.87042601
60HTLV-I infection_Homo sapiens_hsa051660.85293450
61Hedgehog signaling pathway_Homo sapiens_hsa043400.84334392
62B cell receptor signaling pathway_Homo sapiens_hsa046620.81286055
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.81062896
64Hippo signaling pathway_Homo sapiens_hsa043900.77942641
65Inositol phosphate metabolism_Homo sapiens_hsa005620.76413226
66Adherens junction_Homo sapiens_hsa045200.76102811
67VEGF signaling pathway_Homo sapiens_hsa043700.71209817
68Insulin signaling pathway_Homo sapiens_hsa049100.71013923
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70041277
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69386482
71Pyrimidine metabolism_Homo sapiens_hsa002400.69260260
72Antigen processing and presentation_Homo sapiens_hsa046120.68630048
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68337827
74Estrogen signaling pathway_Homo sapiens_hsa049150.68325573
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67567938
76Long-term potentiation_Homo sapiens_hsa047200.66737808
77Basal cell carcinoma_Homo sapiens_hsa052170.65930172
78Prostate cancer_Homo sapiens_hsa052150.65578666
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65564132
80Proteoglycans in cancer_Homo sapiens_hsa052050.65004980
81Pathways in cancer_Homo sapiens_hsa052000.64594905
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64226131
83Selenocompound metabolism_Homo sapiens_hsa004500.63787943
84Colorectal cancer_Homo sapiens_hsa052100.63376780
85Pancreatic cancer_Homo sapiens_hsa052120.62328194
86TGF-beta signaling pathway_Homo sapiens_hsa043500.62268380
87Endometrial cancer_Homo sapiens_hsa052130.60919500
88MAPK signaling pathway_Homo sapiens_hsa040100.60659681
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60643617
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.60528402
91Non-homologous end-joining_Homo sapiens_hsa034500.58818874
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58417073
93Primary immunodeficiency_Homo sapiens_hsa053400.58387526
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.58378784
95Leishmaniasis_Homo sapiens_hsa051400.57115661
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56609454
97Systemic lupus erythematosus_Homo sapiens_hsa053220.56108820
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52856398
99Melanogenesis_Homo sapiens_hsa049160.51797346
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.51749175
101Epstein-Barr virus infection_Homo sapiens_hsa051690.51508349
102RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51473566
103Hepatitis B_Homo sapiens_hsa051610.50447123
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50260705
105Arachidonic acid metabolism_Homo sapiens_hsa005900.50014907
106Hepatitis C_Homo sapiens_hsa051600.48732478
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.47923966
108Nitrogen metabolism_Homo sapiens_hsa009100.47789398
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.45831486
110HIF-1 signaling pathway_Homo sapiens_hsa040660.44991952
111GnRH signaling pathway_Homo sapiens_hsa049120.44831084
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44306799
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44237126
114AMPK signaling pathway_Homo sapiens_hsa041520.43660017
115Renal cell carcinoma_Homo sapiens_hsa052110.43626673
116Basal transcription factors_Homo sapiens_hsa030220.42656023
117T cell receptor signaling pathway_Homo sapiens_hsa046600.42600203
118Linoleic acid metabolism_Homo sapiens_hsa005910.42206989
119Rap1 signaling pathway_Homo sapiens_hsa040150.42106893
120Tight junction_Homo sapiens_hsa045300.41024025
121Influenza A_Homo sapiens_hsa051640.40870786
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.40667028
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40619696
124Measles_Homo sapiens_hsa051620.40186329
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39697856
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39443076
127Insulin resistance_Homo sapiens_hsa049310.38439947
128Gap junction_Homo sapiens_hsa045400.38408868
129Purine metabolism_Homo sapiens_hsa002300.38069782
130Type II diabetes mellitus_Homo sapiens_hsa049300.37940630
131alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37227149
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.36431414
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.36152015
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35087463
135Focal adhesion_Homo sapiens_hsa045100.34358610
136Long-term depression_Homo sapiens_hsa047300.34051283

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