YY1AP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The encoded gene product presumably interacts with YY1 protein; however, its exact function is not known. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)4.66780715
2positive regulation of gamma-delta T cell activation (GO:0046645)4.41122487
3histone H3-K36 demethylation (GO:0070544)4.21255388
4germinal center formation (GO:0002467)3.90032352
5neutrophil activation involved in immune response (GO:0002283)3.78573960
6regulation of T-helper 2 cell differentiation (GO:0045628)3.74198355
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.70262598
8positive regulation by organism of defense response of other organism involved in symbiotic interact3.70262598
9modulation by symbiont of host immune response (GO:0052553)3.70262598
10positive regulation by symbiont of host defense response (GO:0052509)3.70262598
11modulation by symbiont of host defense response (GO:0052031)3.70262598
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.70262598
13macrophage activation involved in immune response (GO:0002281)3.65493810
14response to peptidoglycan (GO:0032494)3.63948721
15histone lysine demethylation (GO:0070076)3.61159264
16histone H3-K9 demethylation (GO:0033169)3.59744555
17negative regulation of cell killing (GO:0031342)3.57152193
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.57152193
19immunoglobulin mediated immune response (GO:0016064)3.55292902
20regulation of gamma-delta T cell activation (GO:0046643)3.52340379
21histone demethylation (GO:0016577)3.49896523
22positive regulation of granulocyte differentiation (GO:0030854)3.47800507
23regulation of nucleobase-containing compound transport (GO:0032239)3.43632689
24regulation of histone H3-K27 methylation (GO:0061085)3.41688794
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.40950550
26regulation of granulocyte differentiation (GO:0030852)3.39778006
27regulation of gamma-delta T cell differentiation (GO:0045586)3.35016845
28negative regulation of granulocyte differentiation (GO:0030853)3.33753627
29regulation of RNA export from nucleus (GO:0046831)3.33571016
30positive regulation of B cell differentiation (GO:0045579)3.30535071
31NIK/NF-kappaB signaling (GO:0038061)3.30106084
32antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.29647879
33definitive hemopoiesis (GO:0060216)3.27530531
34response to muramyl dipeptide (GO:0032495)3.19979783
35regulation of NFAT protein import into nucleus (GO:0051532)3.18137256
36regulation of necroptotic process (GO:0060544)3.15009028
37B cell receptor signaling pathway (GO:0050853)3.12751533
38antigen processing and presentation of endogenous antigen (GO:0019883)3.10914277
39regulation of ARF protein signal transduction (GO:0032012)3.10086633
40antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.08377541
41protein demethylation (GO:0006482)3.06139260
42protein dealkylation (GO:0008214)3.06139260
43regulation of chromatin binding (GO:0035561)3.00132188
44poly(A)+ mRNA export from nucleus (GO:0016973)2.95301672
45regulation of B cell receptor signaling pathway (GO:0050855)2.94071285
46positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.93959152
47negative regulation of interleukin-12 production (GO:0032695)2.92246029
48negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.89601253
49negative regulation of T-helper cell differentiation (GO:0045623)2.88488154
50negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.88488154
51regulation of interferon-beta biosynthetic process (GO:0045357)2.87636192
52detection of other organism (GO:0098543)2.86129478
53interferon-gamma secretion (GO:0072643)2.85661553
54leukocyte aggregation (GO:0070486)2.84733677
55detection of bacterium (GO:0016045)2.82487907
56positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.81824545
57regulation of mast cell degranulation (GO:0043304)2.79682457
58histone H3-K9 modification (GO:0061647)2.78526791
59T cell selection (GO:0045058)2.70784392
60positive T cell selection (GO:0043368)2.70031941
61positive thymic T cell selection (GO:0045059)2.67981728
62histone H3-K4 methylation (GO:0051568)2.67090056
63negative regulation of histone methylation (GO:0031061)2.66124553
64positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.63031377
65regulation of leukocyte degranulation (GO:0043300)2.61803338
66negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.59746132
67thymic T cell selection (GO:0045061)2.58361715
68intracellular estrogen receptor signaling pathway (GO:0030520)2.58083147
69neutrophil activation (GO:0042119)2.57818007
70cellular extravasation (GO:0045123)2.56422095
71myeloid cell activation involved in immune response (GO:0002275)2.56338641
72regulation of mast cell activation involved in immune response (GO:0033006)2.55407078
73B cell mediated immunity (GO:0019724)2.54682752
74JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.53658334
75lipopolysaccharide-mediated signaling pathway (GO:0031663)2.53618996
76response to type I interferon (GO:0034340)2.51224336
77type I interferon signaling pathway (GO:0060337)2.50771175
78cellular response to type I interferon (GO:0071357)2.50771175
79detection of external biotic stimulus (GO:0098581)2.49758594
80peptidyl-lysine trimethylation (GO:0018023)2.49116756
81signal complex assembly (GO:0007172)2.48512174
82negative regulation of cytokine production involved in immune response (GO:0002719)2.47716020
83negative thymic T cell selection (GO:0045060)2.47144148
84cellular response to virus (GO:0098586)2.46123993
85oxygen transport (GO:0015671)2.46068462
86embryonic process involved in female pregnancy (GO:0060136)2.45737967
87detection of molecule of bacterial origin (GO:0032490)2.45326640
88granulocyte activation (GO:0036230)2.44267479
89erythrocyte development (GO:0048821)2.42837145
90negative regulation of necroptotic process (GO:0060546)2.42455791
91regulation of myeloid leukocyte mediated immunity (GO:0002886)2.42342252
92histone lysine methylation (GO:0034968)2.42221102
93nuclear pore complex assembly (GO:0051292)2.41944908
94positive regulation of histone deacetylation (GO:0031065)2.40944320
95negative regulation of type 2 immune response (GO:0002829)2.40487323
96positive regulation of interferon-alpha production (GO:0032727)2.39632567
97macrophage activation (GO:0042116)2.38008242
98modulation by virus of host process (GO:0019054)2.37942723
99regulation of interferon-alpha production (GO:0032647)2.37832721
100positive regulation of Rap GTPase activity (GO:0032854)2.35766836

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human3.89210192
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.53958337
3VDR_21846776_ChIP-Seq_THP-1_Human3.13778417
4MYC_22102868_ChIP-Seq_BL_Human2.99610989
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.76603168
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.65739913
7TCF7_22412390_ChIP-Seq_EML_Mouse2.61422018
8TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.51869979
9VDR_24763502_ChIP-Seq_THP-1_Human2.45990798
10SCL_19346495_ChIP-Seq_HPC-7_Human2.44849029
11* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.39257717
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.38075456
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.36437887
14* MAF_26560356_Chip-Seq_TH1_Human2.34909012
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.28919829
16* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.26361622
17KDM2B_26808549_Chip-Seq_SUP-B15_Human2.24523325
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.23660249
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.23150273
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.21489363
21* KDM2B_26808549_Chip-Seq_DND41_Human2.20596327
22SPI1_23127762_ChIP-Seq_K562_Human2.20327653
23E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.18723983
24UTX_26944678_Chip-Seq_JUKART_Human2.18647474
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.16689908
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.04564642
27RUNX1_22412390_ChIP-Seq_EML_Mouse2.02962983
28GATA1_19941826_ChIP-Seq_K562_Human2.02218118
29TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.01293331
30CIITA_25753668_ChIP-Seq_RAJI_Human1.99185350
31* MYB_26560356_Chip-Seq_TH2_Human1.99169757
32MAF_26560356_Chip-Seq_TH2_Human1.97724970
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.96427727
34* MYB_26560356_Chip-Seq_TH1_Human1.96098832
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.94019233
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.91944568
37RUNX_20019798_ChIP-Seq_JUKART_Human1.90446347
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.90383201
39IRF8_27001747_Chip-Seq_BMDM_Mouse1.86427139
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.85087587
41FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.83064409
42SPI1_23547873_ChIP-Seq_NB4_Human1.76608604
43GATA1_19941827_ChIP-Seq_MEL_Mouse1.74954248
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.74037227
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.72944285
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.70905847
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.66960616
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.61620338
49MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.60131052
50RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.59099670
51NCOR1_26117541_ChIP-Seq_K562_Human1.56850008
52CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.51832500
53GATA3_27048872_Chip-Seq_THYMUS_Human1.49412341
54STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.47725582
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.47550533
56* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.43414593
57GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42567196
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40077850
59GATA2_19941826_ChIP-Seq_K562_Human1.38710084
60TFEB_21752829_ChIP-Seq_HELA_Human1.35265704
61* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34886202
62KDM5A_27292631_Chip-Seq_BREAST_Human1.34799654
63KDM2B_26808549_Chip-Seq_JURKAT_Human1.34522667
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34221542
65LXR_22292898_ChIP-Seq_THP-1_Human1.34184151
66* RACK7_27058665_Chip-Seq_MCF-7_Human1.31577327
67GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30803168
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.30532814
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29424797
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26664264
71GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25817855
72KDM2B_26808549_Chip-Seq_K562_Human1.22303496
73GATA1_22025678_ChIP-Seq_K562_Human1.20476391
74SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18941689
75FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18474959
76ESR1_20079471_ChIP-ChIP_T-47D_Human1.17692329
77CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15944702
78ELF1_20517297_ChIP-Seq_JURKAT_Human1.15056331
79CTCF_21964334_ChIP-Seq_BJAB-B_Human1.10743193
80P68_20966046_ChIP-Seq_HELA_Human1.09931734
81VDR_24787735_ChIP-Seq_THP-1_Human1.08918189
82BCOR_27268052_Chip-Seq_Bcells_Human1.07722318
83PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07250916
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06231332
85* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05868588
86PU_27001747_Chip-Seq_BMDM_Mouse1.04109331
87SA1_27219007_Chip-Seq_ERYTHROID_Human1.03880038
88CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03438977
89RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02947715
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02339297
91LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02088304
92VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01755409
93TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01693356
94* CREB1_26743006_Chip-Seq_LNCaP_Human1.01153012
95KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00337610
96TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00284986
97RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99587730
98SMC4_20622854_ChIP-Seq_HELA_Human0.99587093
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99105590
100PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96088329

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.25727744
2MP0005451_abnormal_body_composition2.87830849
3MP0003436_decreased_susceptibility_to2.80134534
4MP0001835_abnormal_antigen_presentation2.60312682
5MP0003656_abnormal_erythrocyte_physiolo2.39436252
6MP0002396_abnormal_hematopoietic_system2.18581104
7MP0005387_immune_system_phenotype2.16833600
8MP0001790_abnormal_immune_system2.16833600
9MP0001800_abnormal_humoral_immune2.13776387
10MP0003724_increased_susceptibility_to2.12393803
11MP0003763_abnormal_thymus_physiology2.11166594
12MP0009278_abnormal_bone_marrow2.09923336
13MP0002419_abnormal_innate_immunity2.08643314
14MP0005000_abnormal_immune_tolerance2.03683992
15MP0000685_abnormal_immune_system2.03435040
16MP0001545_abnormal_hematopoietic_system2.00961169
17MP0005397_hematopoietic_system_phenotyp2.00961169
18MP0005025_abnormal_response_to1.96067701
19MP0004808_abnormal_hematopoietic_stem1.92907977
20MP0002398_abnormal_bone_marrow1.92456199
21MP0002723_abnormal_immune_serum1.92006443
22MP0003172_abnormal_lysosome_physiology1.89727036
23MP0005464_abnormal_platelet_physiology1.87634826
24MP0002420_abnormal_adaptive_immunity1.85080764
25MP0003300_gastrointestinal_ulcer1.83636699
26MP0004947_skin_inflammation1.82307415
27MP0002452_abnormal_antigen_presenting1.81524408
28MP0001819_abnormal_immune_cell1.80390096
29MP0003183_abnormal_peptide_metabolism1.77942925
30MP0008260_abnormal_autophagy1.74460858
31MP0002405_respiratory_system_inflammati1.67340658
32MP0005058_abnormal_lysosome_morphology1.64027444
33MP0002148_abnormal_hypersensitivity_rea1.61336866
34MP0000716_abnormal_immune_system1.61056414
35MP0000703_abnormal_thymus_morphology1.60912880
36MP0009785_altered_susceptibility_to1.59896382
37MP0005671_abnormal_response_to1.59201257
38MP0002332_abnormal_exercise_endurance1.58754431
39MP0001873_stomach_inflammation1.58279119
40MP0009333_abnormal_splenocyte_physiolog1.57988478
41MP0002722_abnormal_immune_system1.55776392
42MP0005083_abnormal_biliary_tract1.54266567
43MP0008057_abnormal_DNA_replication1.53338372
44MP0002009_preneoplasia1.52499884
45MP0003828_pulmonary_edema1.51410000
46MP0005076_abnormal_cell_differentiation1.47345012
47MP0005310_abnormal_salivary_gland1.46044815
48MP0004510_myositis1.45244717
49MP0000689_abnormal_spleen_morphology1.44501161
50MP0010155_abnormal_intestine_physiology1.38927951
51MP0002429_abnormal_blood_cell1.38198339
52MP0009840_abnormal_foam_cell1.33190794
53MP0004185_abnormal_adipocyte_glucose1.32229794
54MP0002138_abnormal_hepatobiliary_system1.31511050
55MP0003191_abnormal_cellular_cholesterol1.24414457
56MP0005410_abnormal_fertilization1.19417126
57MP0005666_abnormal_adipose_tissue1.14206005
58MP0000604_amyloidosis1.13084962
59MP0001533_abnormal_skeleton_physiology1.12525446
60MP0003221_abnormal_cardiomyocyte_apopto1.12467500
61MP0003453_abnormal_keratinocyte_physiol1.09239991
62MP0003329_amyloid_beta_deposits1.07753061
63MP0001845_abnormal_inflammatory_respons1.07145751
64MP0004264_abnormal_extraembryonic_tissu1.06169369
65MP0008004_abnormal_stomach_pH1.05315104
66MP0003111_abnormal_nucleus_morphology1.04415912
67MP0006082_CNS_inflammation1.04366665
68MP0000015_abnormal_ear_pigmentation1.02571276
69MP0005409_darkened_coat_color1.00719236
70MP0008961_abnormal_basal_metabolism0.97377783
71MP0003045_fibrosis0.97159185
72MP0008469_abnormal_protein_level0.95796271
73MP0001348_abnormal_lacrimal_gland0.95233966
74MP0008058_abnormal_DNA_repair0.95023091
75MP0002166_altered_tumor_susceptibility0.93888963
76MP0009115_abnormal_fat_cell0.92489759
77MP0000313_abnormal_cell_death0.90279068
78MP0005375_adipose_tissue_phenotype0.89235055
79MP0002132_abnormal_respiratory_system0.88640794
80MP0001853_heart_inflammation0.88348788
81MP0001929_abnormal_gametogenesis0.87627391
82MP0002998_abnormal_bone_remodeling0.86991267
83MP0008995_early_reproductive_senescence0.85176335
84MP0009764_decreased_sensitivity_to0.83188160
85MP0001851_eye_inflammation0.82722581
86MP0002971_abnormal_brown_adipose0.80757250
87MP0003075_altered_response_to0.80015823
88MP0003866_abnormal_defecation0.78866058
89MP0004233_abnormal_muscle_weight0.78457690
90MP0003077_abnormal_cell_cycle0.77686425
91MP0000465_gastrointestinal_hemorrhage0.75302453
92MP0005621_abnormal_cell_physiology0.74926644
93MP0002019_abnormal_tumor_incidence0.74696061
94MP0003879_abnormal_hair_cell0.74610381
95MP0008874_decreased_physiological_sensi0.72649563
96MP0002970_abnormal_white_adipose0.71125292
97MP0003091_abnormal_cell_migration0.71095904
98MP0003646_muscle_fatigue0.70103303
99MP0003690_abnormal_glial_cell0.69950369
100MP0010352_gastrointestinal_tract_polyps0.69372877

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)3.95978565
2Recurrent bacterial skin infections (HP:0005406)3.74284372
3Recurrent abscess formation (HP:0002722)3.68171882
4Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.60631103
5Slow saccadic eye movements (HP:0000514)3.44829991
6Abnormality of the fingertips (HP:0001211)3.44712747
7Abnormality of macrophages (HP:0004311)3.36317958
8Gastrointestinal inflammation (HP:0004386)3.21094198
9Myositis (HP:0100614)3.20088976
10Prolonged bleeding time (HP:0003010)3.19827723
11Inflammation of the large intestine (HP:0002037)3.19493835
12Colitis (HP:0002583)3.11898408
13Petechiae (HP:0000967)2.95849412
14Increased IgE level (HP:0003212)2.90115437
15Orchitis (HP:0100796)2.89473125
16Spontaneous hematomas (HP:0007420)2.82599643
17Fatigue (HP:0012378)2.74504655
18Increased serum ferritin (HP:0003281)2.71821825
19Recurrent fungal infections (HP:0002841)2.69980456
20Hypochromic anemia (HP:0001931)2.69336608
21Stomatitis (HP:0010280)2.66312588
22Retrobulbar optic neuritis (HP:0100654)2.63432247
23Optic neuritis (HP:0100653)2.63432247
24Cellulitis (HP:0100658)2.61446112
25Asymmetric septal hypertrophy (HP:0001670)2.61312334
26Abnormal delayed hypersensitivity skin test (HP:0002963)2.60868750
27Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.55941474
28Hypochromic microcytic anemia (HP:0004840)2.53533447
29Polycythemia (HP:0001901)2.51892258
30Deep palmar crease (HP:0006191)2.51354725
31Obstructive lung disease (HP:0006536)2.50195818
32Chronic obstructive pulmonary disease (HP:0006510)2.50195818
33Autoimmune hemolytic anemia (HP:0001890)2.49514182
34Mediastinal lymphadenopathy (HP:0100721)2.48811223
35Gingivitis (HP:0000230)2.46978684
36Obstructive sleep apnea (HP:0002870)2.46457785
37Vasculitis (HP:0002633)2.46188199
38Heterotopia (HP:0002282)2.45940214
39Severe visual impairment (HP:0001141)2.42325669
40Distal lower limb amyotrophy (HP:0008944)2.42289334
41Meningitis (HP:0001287)2.42216400
42Abnormality of the heme biosynthetic pathway (HP:0010472)2.38802329
43Gastrointestinal infarctions (HP:0005244)2.38554809
44Sparse lateral eyebrow (HP:0005338)2.35235526
45Abnormality of iron homeostasis (HP:0011031)2.31416971
46Chest pain (HP:0100749)2.29563815
47Elevated erythrocyte sedimentation rate (HP:0003565)2.27854843
48Epistaxis (HP:0000421)2.27439934
49Macroorchidism (HP:0000053)2.26811994
50Disinhibition (HP:0000734)2.26031970
51Exercise-induced myalgia (HP:0003738)2.22523293
52Resting tremor (HP:0002322)2.22023299
53Gastrointestinal stroma tumor (HP:0100723)2.19581637
54Urticaria (HP:0001025)2.19001448
55Reticulocytosis (HP:0001923)2.18341471
56Neuronal loss in central nervous system (HP:0002529)2.18180678
57Gingival bleeding (HP:0000225)2.15951529
58Loss of speech (HP:0002371)2.15800221
59Recurrent skin infections (HP:0001581)2.15668499
60Truncal obesity (HP:0001956)2.15110919
61Recurrent gram-negative bacterial infections (HP:0005420)2.11767186
62Abnormality of transition element cation homeostasis (HP:0011030)2.10634795
63Recurrent viral infections (HP:0004429)2.07212368
64Osteomyelitis (HP:0002754)2.06872208
65Nasal polyposis (HP:0100582)2.06613227
66Abnormal large intestine physiology (HP:0012700)2.04851773
67Acute myeloid leukemia (HP:0004808)2.04797823
68Hyperkalemia (HP:0002153)2.04320370
69Encephalitis (HP:0002383)2.02655446
70Bowel incontinence (HP:0002607)2.02120604
71Microcytic anemia (HP:0001935)2.01011932
72Menstrual irregularities (HP:0000858)1.99457052
73Centrally nucleated skeletal muscle fibers (HP:0003687)1.95814261
74Chronic mucocutaneous candidiasis (HP:0002728)1.89630359
75Recurrent cutaneous fungal infections (HP:0011370)1.89630359
76Autoimmune thrombocytopenia (HP:0001973)1.88836514
77Poor eye contact (HP:0000817)1.88552707
78Granulocytopenia (HP:0001913)1.88466738
79Abnormality of glycolipid metabolism (HP:0010969)1.87252045
80Abnormality of liposaccharide metabolism (HP:0010968)1.87252045
81Abnormality of glycosphingolipid metabolism (HP:0004343)1.87252045
82Distal lower limb muscle weakness (HP:0009053)1.86570376
83Episodic fever (HP:0001954)1.85858471
84Keratoconjunctivitis sicca (HP:0001097)1.82359237
85Stomach cancer (HP:0012126)1.81748816
86Pustule (HP:0200039)1.80352098
87Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.79324538
88Panhypogammaglobulinemia (HP:0003139)1.76772791
89Hemoptysis (HP:0002105)1.75066468
90Lymphopenia (HP:0001888)1.75012999
91Decreased motor nerve conduction velocity (HP:0003431)1.74328479
92Amelogenesis imperfecta (HP:0000705)1.74291369
93Abnormality of the periventricular white matter (HP:0002518)1.73083619
94Lip pit (HP:0100267)1.71002828
95Abnormality of the endocardium (HP:0004306)1.69848998
96Impaired platelet aggregation (HP:0003540)1.67798173
97Abnormal platelet function (HP:0011869)1.67798173
98Dysostosis multiplex (HP:0000943)1.67651556
99Malnutrition (HP:0004395)1.66562236
100Purpura (HP:0000979)1.65537320

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.58522908
2CDK123.10984479
3PRPF4B2.98594923
4MAP3K102.98026790
5ERN12.42209998
6TRIB32.36006317
7MAP2K32.29791961
8MAP4K12.08459412
9TAOK12.03046627
10MARK21.85490268
11IRAK41.82158797
12AKT31.79489638
13RIPK11.78896901
14KSR21.69298359
15BLK1.66478140
16ZAP701.60875696
17ICK1.58828945
18MAP3K131.51890877
19SIK31.47890696
20MAP3K11.47661298
21MAP3K31.47216215
22BRD41.45660246
23TYK21.41745477
24STK381.38476187
25CDK91.38243521
26WNK11.33468627
27SGK31.33271928
28IRAK31.32605021
29PRKD21.31058872
30SIK21.30852534
31BTK1.27383435
32MAP3K141.25478328
33BRAF1.23622379
34TNK21.23514727
35TBK11.20662938
36CSK1.19806179
37FES1.17644786
38EPHB11.15604571
39SYK1.15407243
40SIK11.14790841
41TAOK21.13838921
42YES11.13593764
43JAK31.13236760
44MAP3K111.12847874
45SMG11.12372524
46PDK11.11802876
47MAP3K21.08640956
48MARK31.08290931
49HIPK21.07542478
50IKBKE1.06370962
51HCK1.06165660
52GRK61.05390377
53PDPK11.01530252
54FGR1.00374056
55MAPK110.99643459
56SGK20.99632118
57JAK20.97884666
58TAOK30.97617270
59CSF1R0.92213600
60TESK20.91441994
61CAMK1D0.90222895
62IKBKB0.89061475
63CAMK1G0.88285492
64NLK0.85232757
65EPHA30.78345347
66IRAK10.78310758
67CDK40.78188149
68MAPK70.76496473
69PIM10.76368829
70MTOR0.74432710
71PIK3CG0.73619309
72MAP2K20.71956213
73CAMK40.71623465
74FGFR30.71020409
75BMX0.67418400
76CDC42BPA0.66668959
77RET0.66153656
78MAPK120.63620216
79ITK0.63393533
80CDK190.63263124
81MAP3K70.61725325
82RAF10.61228675
83MATK0.60558949
84LYN0.58693746
85RPS6KL10.58102767
86RPS6KC10.58102767
87IRAK20.57436283
88TEC0.55344941
89BMPR20.55050290
90LCK0.54220655
91PDGFRB0.53816346
92SGK2230.53188315
93SGK4940.53188315
94KSR10.53062041
95FGFR40.50254805
96RPS6KA60.48767722
97MAPK30.47543283
98CDK80.46911125
99CDK70.46629260
100MAP3K80.45192968

Predicted pathways (KEGG)

RankGene SetZ-score
1Acute myeloid leukemia_Homo sapiens_hsa052212.44516714
2B cell receptor signaling pathway_Homo sapiens_hsa046622.37820864
3Osteoclast differentiation_Homo sapiens_hsa043802.22649677
4Leishmaniasis_Homo sapiens_hsa051401.91783638
5Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.88430444
6Non-small cell lung cancer_Homo sapiens_hsa052231.83056164
7Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.82086479
8Chronic myeloid leukemia_Homo sapiens_hsa052201.74132080
9Toll-like receptor signaling pathway_Homo sapiens_hsa046201.72998059
10Influenza A_Homo sapiens_hsa051641.71455877
11T cell receptor signaling pathway_Homo sapiens_hsa046601.64750078
12Dorso-ventral axis formation_Homo sapiens_hsa043201.60994850
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.55179033
14Hepatitis B_Homo sapiens_hsa051611.51788939
15Allograft rejection_Homo sapiens_hsa053301.51215907
16Tuberculosis_Homo sapiens_hsa051521.51194350
17Viral carcinogenesis_Homo sapiens_hsa052031.49972582
18Measles_Homo sapiens_hsa051621.49026473
19Pancreatic cancer_Homo sapiens_hsa052121.48530093
20TNF signaling pathway_Homo sapiens_hsa046681.45719376
21Autoimmune thyroid disease_Homo sapiens_hsa053201.41923502
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.41622569
23Herpes simplex infection_Homo sapiens_hsa051681.41365444
24Phosphatidylinositol signaling system_Homo sapiens_hsa040701.37689908
25Toxoplasmosis_Homo sapiens_hsa051451.37543600
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.36714969
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.34367604
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.32312228
29VEGF signaling pathway_Homo sapiens_hsa043701.29794467
30Renal cell carcinoma_Homo sapiens_hsa052111.28868894
31Prolactin signaling pathway_Homo sapiens_hsa049171.25489613
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.24412115
33Neurotrophin signaling pathway_Homo sapiens_hsa047221.23977287
34Staphylococcus aureus infection_Homo sapiens_hsa051501.23948085
35ErbB signaling pathway_Homo sapiens_hsa040121.23746275
36Systemic lupus erythematosus_Homo sapiens_hsa053221.21912899
37Graft-versus-host disease_Homo sapiens_hsa053321.20099511
38mTOR signaling pathway_Homo sapiens_hsa041501.19567194
39Viral myocarditis_Homo sapiens_hsa054161.17441312
40Endometrial cancer_Homo sapiens_hsa052131.15539670
41Hepatitis C_Homo sapiens_hsa051601.15166215
42Other glycan degradation_Homo sapiens_hsa005111.11495525
43Apoptosis_Homo sapiens_hsa042101.11389250
44Chemokine signaling pathway_Homo sapiens_hsa040621.09552877
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.09124912
46Inositol phosphate metabolism_Homo sapiens_hsa005621.08678734
47Transcriptional misregulation in cancer_Homo sapiens_hsa052021.08541577
48NOD-like receptor signaling pathway_Homo sapiens_hsa046211.04580596
49Primary immunodeficiency_Homo sapiens_hsa053401.03164755
50Notch signaling pathway_Homo sapiens_hsa043301.03153650
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.02740941
52Choline metabolism in cancer_Homo sapiens_hsa052310.99363183
53FoxO signaling pathway_Homo sapiens_hsa040680.98129807
54Longevity regulating pathway - mammal_Homo sapiens_hsa042110.97188349
55Legionellosis_Homo sapiens_hsa051340.96526084
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94256446
57Type I diabetes mellitus_Homo sapiens_hsa049400.93841712
58Endocytosis_Homo sapiens_hsa041440.93808273
59Glioma_Homo sapiens_hsa052140.92640040
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91664154
61Prostate cancer_Homo sapiens_hsa052150.91553345
62Bladder cancer_Homo sapiens_hsa052190.91401762
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91110366
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.90390062
65Thyroid cancer_Homo sapiens_hsa052160.89636168
66Platelet activation_Homo sapiens_hsa046110.86765497
67Malaria_Homo sapiens_hsa051440.86423280
68Type II diabetes mellitus_Homo sapiens_hsa049300.85424493
69Colorectal cancer_Homo sapiens_hsa052100.85291648
70Epstein-Barr virus infection_Homo sapiens_hsa051690.82816399
71Alcoholism_Homo sapiens_hsa050340.82764519
72HTLV-I infection_Homo sapiens_hsa051660.82691334
73Asthma_Homo sapiens_hsa053100.82405967
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81743360
75Estrogen signaling pathway_Homo sapiens_hsa049150.81177444
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.81040206
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80869018
78GnRH signaling pathway_Homo sapiens_hsa049120.80110297
79MAPK signaling pathway_Homo sapiens_hsa040100.78813322
80Insulin resistance_Homo sapiens_hsa049310.77358373
81Insulin signaling pathway_Homo sapiens_hsa049100.76737852
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75079865
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.74844242
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73759173
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73443806
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73187623
87Antigen processing and presentation_Homo sapiens_hsa046120.73028119
88Long-term potentiation_Homo sapiens_hsa047200.68759621
89mRNA surveillance pathway_Homo sapiens_hsa030150.65910031
90Hematopoietic cell lineage_Homo sapiens_hsa046400.65061244
91HIF-1 signaling pathway_Homo sapiens_hsa040660.62790889
92Lysosome_Homo sapiens_hsa041420.61149385
93Pertussis_Homo sapiens_hsa051330.59366525
94African trypanosomiasis_Homo sapiens_hsa051430.57024139
95Phagosome_Homo sapiens_hsa041450.56682034
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.54694907
97Shigellosis_Homo sapiens_hsa051310.50631474
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.48589160
99Lysine degradation_Homo sapiens_hsa003100.47679442
100Rheumatoid arthritis_Homo sapiens_hsa053230.47568161

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