Rank | Gene Set | Z-score |
---|---|---|
1 | negative regulation of erythrocyte differentiation (GO:0045647) | 4.66780715 |
2 | positive regulation of gamma-delta T cell activation (GO:0046645) | 4.41122487 |
3 | histone H3-K36 demethylation (GO:0070544) | 4.21255388 |
4 | germinal center formation (GO:0002467) | 3.90032352 |
5 | neutrophil activation involved in immune response (GO:0002283) | 3.78573960 |
6 | regulation of T-helper 2 cell differentiation (GO:0045628) | 3.74198355 |
7 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 3.70262598 |
8 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 3.70262598 |
9 | modulation by symbiont of host immune response (GO:0052553) | 3.70262598 |
10 | positive regulation by symbiont of host defense response (GO:0052509) | 3.70262598 |
11 | modulation by symbiont of host defense response (GO:0052031) | 3.70262598 |
12 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 3.70262598 |
13 | macrophage activation involved in immune response (GO:0002281) | 3.65493810 |
14 | response to peptidoglycan (GO:0032494) | 3.63948721 |
15 | histone lysine demethylation (GO:0070076) | 3.61159264 |
16 | histone H3-K9 demethylation (GO:0033169) | 3.59744555 |
17 | negative regulation of cell killing (GO:0031342) | 3.57152193 |
18 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 3.57152193 |
19 | immunoglobulin mediated immune response (GO:0016064) | 3.55292902 |
20 | regulation of gamma-delta T cell activation (GO:0046643) | 3.52340379 |
21 | histone demethylation (GO:0016577) | 3.49896523 |
22 | positive regulation of granulocyte differentiation (GO:0030854) | 3.47800507 |
23 | regulation of nucleobase-containing compound transport (GO:0032239) | 3.43632689 |
24 | regulation of histone H3-K27 methylation (GO:0061085) | 3.41688794 |
25 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 3.40950550 |
26 | regulation of granulocyte differentiation (GO:0030852) | 3.39778006 |
27 | regulation of gamma-delta T cell differentiation (GO:0045586) | 3.35016845 |
28 | negative regulation of granulocyte differentiation (GO:0030853) | 3.33753627 |
29 | regulation of RNA export from nucleus (GO:0046831) | 3.33571016 |
30 | positive regulation of B cell differentiation (GO:0045579) | 3.30535071 |
31 | NIK/NF-kappaB signaling (GO:0038061) | 3.30106084 |
32 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 3.29647879 |
33 | definitive hemopoiesis (GO:0060216) | 3.27530531 |
34 | response to muramyl dipeptide (GO:0032495) | 3.19979783 |
35 | regulation of NFAT protein import into nucleus (GO:0051532) | 3.18137256 |
36 | regulation of necroptotic process (GO:0060544) | 3.15009028 |
37 | B cell receptor signaling pathway (GO:0050853) | 3.12751533 |
38 | antigen processing and presentation of endogenous antigen (GO:0019883) | 3.10914277 |
39 | regulation of ARF protein signal transduction (GO:0032012) | 3.10086633 |
40 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 3.08377541 |
41 | protein demethylation (GO:0006482) | 3.06139260 |
42 | protein dealkylation (GO:0008214) | 3.06139260 |
43 | regulation of chromatin binding (GO:0035561) | 3.00132188 |
44 | poly(A)+ mRNA export from nucleus (GO:0016973) | 2.95301672 |
45 | regulation of B cell receptor signaling pathway (GO:0050855) | 2.94071285 |
46 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 2.93959152 |
47 | negative regulation of interleukin-12 production (GO:0032695) | 2.92246029 |
48 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 2.89601253 |
49 | negative regulation of T-helper cell differentiation (GO:0045623) | 2.88488154 |
50 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 2.88488154 |
51 | regulation of interferon-beta biosynthetic process (GO:0045357) | 2.87636192 |
52 | detection of other organism (GO:0098543) | 2.86129478 |
53 | interferon-gamma secretion (GO:0072643) | 2.85661553 |
54 | leukocyte aggregation (GO:0070486) | 2.84733677 |
55 | detection of bacterium (GO:0016045) | 2.82487907 |
56 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 2.81824545 |
57 | regulation of mast cell degranulation (GO:0043304) | 2.79682457 |
58 | histone H3-K9 modification (GO:0061647) | 2.78526791 |
59 | T cell selection (GO:0045058) | 2.70784392 |
60 | positive T cell selection (GO:0043368) | 2.70031941 |
61 | positive thymic T cell selection (GO:0045059) | 2.67981728 |
62 | histone H3-K4 methylation (GO:0051568) | 2.67090056 |
63 | negative regulation of histone methylation (GO:0031061) | 2.66124553 |
64 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 2.63031377 |
65 | regulation of leukocyte degranulation (GO:0043300) | 2.61803338 |
66 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 2.59746132 |
67 | thymic T cell selection (GO:0045061) | 2.58361715 |
68 | intracellular estrogen receptor signaling pathway (GO:0030520) | 2.58083147 |
69 | neutrophil activation (GO:0042119) | 2.57818007 |
70 | cellular extravasation (GO:0045123) | 2.56422095 |
71 | myeloid cell activation involved in immune response (GO:0002275) | 2.56338641 |
72 | regulation of mast cell activation involved in immune response (GO:0033006) | 2.55407078 |
73 | B cell mediated immunity (GO:0019724) | 2.54682752 |
74 | JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397) | 2.53658334 |
75 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 2.53618996 |
76 | response to type I interferon (GO:0034340) | 2.51224336 |
77 | type I interferon signaling pathway (GO:0060337) | 2.50771175 |
78 | cellular response to type I interferon (GO:0071357) | 2.50771175 |
79 | detection of external biotic stimulus (GO:0098581) | 2.49758594 |
80 | peptidyl-lysine trimethylation (GO:0018023) | 2.49116756 |
81 | signal complex assembly (GO:0007172) | 2.48512174 |
82 | negative regulation of cytokine production involved in immune response (GO:0002719) | 2.47716020 |
83 | negative thymic T cell selection (GO:0045060) | 2.47144148 |
84 | cellular response to virus (GO:0098586) | 2.46123993 |
85 | oxygen transport (GO:0015671) | 2.46068462 |
86 | embryonic process involved in female pregnancy (GO:0060136) | 2.45737967 |
87 | detection of molecule of bacterial origin (GO:0032490) | 2.45326640 |
88 | granulocyte activation (GO:0036230) | 2.44267479 |
89 | erythrocyte development (GO:0048821) | 2.42837145 |
90 | negative regulation of necroptotic process (GO:0060546) | 2.42455791 |
91 | regulation of myeloid leukocyte mediated immunity (GO:0002886) | 2.42342252 |
92 | histone lysine methylation (GO:0034968) | 2.42221102 |
93 | nuclear pore complex assembly (GO:0051292) | 2.41944908 |
94 | positive regulation of histone deacetylation (GO:0031065) | 2.40944320 |
95 | negative regulation of type 2 immune response (GO:0002829) | 2.40487323 |
96 | positive regulation of interferon-alpha production (GO:0032727) | 2.39632567 |
97 | macrophage activation (GO:0042116) | 2.38008242 |
98 | modulation by virus of host process (GO:0019054) | 2.37942723 |
99 | regulation of interferon-alpha production (GO:0032647) | 2.37832721 |
100 | positive regulation of Rap GTPase activity (GO:0032854) | 2.35766836 |
Rank | Gene Set | Z-score |
---|---|---|
1 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.89210192 |
2 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.53958337 |
3 | VDR_21846776_ChIP-Seq_THP-1_Human | 3.13778417 |
4 | MYC_22102868_ChIP-Seq_BL_Human | 2.99610989 |
5 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.76603168 |
6 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.65739913 |
7 | TCF7_22412390_ChIP-Seq_EML_Mouse | 2.61422018 |
8 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.51869979 |
9 | VDR_24763502_ChIP-Seq_THP-1_Human | 2.45990798 |
10 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.44849029 |
11 | * KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 2.39257717 |
12 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.38075456 |
13 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.36437887 |
14 | * MAF_26560356_Chip-Seq_TH1_Human | 2.34909012 |
15 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.28919829 |
16 | * KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 2.26361622 |
17 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 2.24523325 |
18 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 2.23660249 |
19 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 2.23150273 |
20 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 2.21489363 |
21 | * KDM2B_26808549_Chip-Seq_DND41_Human | 2.20596327 |
22 | SPI1_23127762_ChIP-Seq_K562_Human | 2.20327653 |
23 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 2.18723983 |
24 | UTX_26944678_Chip-Seq_JUKART_Human | 2.18647474 |
25 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.16689908 |
26 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.04564642 |
27 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 2.02962983 |
28 | GATA1_19941826_ChIP-Seq_K562_Human | 2.02218118 |
29 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 2.01293331 |
30 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.99185350 |
31 | * MYB_26560356_Chip-Seq_TH2_Human | 1.99169757 |
32 | MAF_26560356_Chip-Seq_TH2_Human | 1.97724970 |
33 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.96427727 |
34 | * MYB_26560356_Chip-Seq_TH1_Human | 1.96098832 |
35 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.94019233 |
36 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.91944568 |
37 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.90446347 |
38 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.90383201 |
39 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.86427139 |
40 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.85087587 |
41 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.83064409 |
42 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.76608604 |
43 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.74954248 |
44 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.74037227 |
45 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.72944285 |
46 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.70905847 |
47 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.66960616 |
48 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.61620338 |
49 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.60131052 |
50 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.59099670 |
51 | NCOR1_26117541_ChIP-Seq_K562_Human | 1.56850008 |
52 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.51832500 |
53 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.49412341 |
54 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.47725582 |
55 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.47550533 |
56 | * PKCTHETA_26484144_Chip-Seq_BREAST_Human | 1.43414593 |
57 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.42567196 |
58 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.40077850 |
59 | GATA2_19941826_ChIP-Seq_K562_Human | 1.38710084 |
60 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.35265704 |
61 | * CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.34886202 |
62 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.34799654 |
63 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.34522667 |
64 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.34221542 |
65 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.34184151 |
66 | * RACK7_27058665_Chip-Seq_MCF-7_Human | 1.31577327 |
67 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.30803168 |
68 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.30532814 |
69 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.29424797 |
70 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.26664264 |
71 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.25817855 |
72 | KDM2B_26808549_Chip-Seq_K562_Human | 1.22303496 |
73 | GATA1_22025678_ChIP-Seq_K562_Human | 1.20476391 |
74 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.18941689 |
75 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.18474959 |
76 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.17692329 |
77 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.15944702 |
78 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.15056331 |
79 | CTCF_21964334_ChIP-Seq_BJAB-B_Human | 1.10743193 |
80 | P68_20966046_ChIP-Seq_HELA_Human | 1.09931734 |
81 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.08918189 |
82 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.07722318 |
83 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 1.07250916 |
84 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.06231332 |
85 | * KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.05868588 |
86 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.04109331 |
87 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.03880038 |
88 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.03438977 |
89 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.02947715 |
90 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.02339297 |
91 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.02088304 |
92 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.01755409 |
93 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.01693356 |
94 | * CREB1_26743006_Chip-Seq_LNCaP_Human | 1.01153012 |
95 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.00337610 |
96 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.00284986 |
97 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.99587730 |
98 | SMC4_20622854_ChIP-Seq_HELA_Human | 0.99587093 |
99 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.99105590 |
100 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.96088329 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0003303_peritoneal_inflammation | 3.25727744 |
2 | MP0005451_abnormal_body_composition | 2.87830849 |
3 | MP0003436_decreased_susceptibility_to | 2.80134534 |
4 | MP0001835_abnormal_antigen_presentation | 2.60312682 |
5 | MP0003656_abnormal_erythrocyte_physiolo | 2.39436252 |
6 | MP0002396_abnormal_hematopoietic_system | 2.18581104 |
7 | MP0005387_immune_system_phenotype | 2.16833600 |
8 | MP0001790_abnormal_immune_system | 2.16833600 |
9 | MP0001800_abnormal_humoral_immune | 2.13776387 |
10 | MP0003724_increased_susceptibility_to | 2.12393803 |
11 | MP0003763_abnormal_thymus_physiology | 2.11166594 |
12 | MP0009278_abnormal_bone_marrow | 2.09923336 |
13 | MP0002419_abnormal_innate_immunity | 2.08643314 |
14 | MP0005000_abnormal_immune_tolerance | 2.03683992 |
15 | MP0000685_abnormal_immune_system | 2.03435040 |
16 | MP0001545_abnormal_hematopoietic_system | 2.00961169 |
17 | MP0005397_hematopoietic_system_phenotyp | 2.00961169 |
18 | MP0005025_abnormal_response_to | 1.96067701 |
19 | MP0004808_abnormal_hematopoietic_stem | 1.92907977 |
20 | MP0002398_abnormal_bone_marrow | 1.92456199 |
21 | MP0002723_abnormal_immune_serum | 1.92006443 |
22 | MP0003172_abnormal_lysosome_physiology | 1.89727036 |
23 | MP0005464_abnormal_platelet_physiology | 1.87634826 |
24 | MP0002420_abnormal_adaptive_immunity | 1.85080764 |
25 | MP0003300_gastrointestinal_ulcer | 1.83636699 |
26 | MP0004947_skin_inflammation | 1.82307415 |
27 | MP0002452_abnormal_antigen_presenting | 1.81524408 |
28 | MP0001819_abnormal_immune_cell | 1.80390096 |
29 | MP0003183_abnormal_peptide_metabolism | 1.77942925 |
30 | MP0008260_abnormal_autophagy | 1.74460858 |
31 | MP0002405_respiratory_system_inflammati | 1.67340658 |
32 | MP0005058_abnormal_lysosome_morphology | 1.64027444 |
33 | MP0002148_abnormal_hypersensitivity_rea | 1.61336866 |
34 | MP0000716_abnormal_immune_system | 1.61056414 |
35 | MP0000703_abnormal_thymus_morphology | 1.60912880 |
36 | MP0009785_altered_susceptibility_to | 1.59896382 |
37 | MP0005671_abnormal_response_to | 1.59201257 |
38 | MP0002332_abnormal_exercise_endurance | 1.58754431 |
39 | MP0001873_stomach_inflammation | 1.58279119 |
40 | MP0009333_abnormal_splenocyte_physiolog | 1.57988478 |
41 | MP0002722_abnormal_immune_system | 1.55776392 |
42 | MP0005083_abnormal_biliary_tract | 1.54266567 |
43 | MP0008057_abnormal_DNA_replication | 1.53338372 |
44 | MP0002009_preneoplasia | 1.52499884 |
45 | MP0003828_pulmonary_edema | 1.51410000 |
46 | MP0005076_abnormal_cell_differentiation | 1.47345012 |
47 | MP0005310_abnormal_salivary_gland | 1.46044815 |
48 | MP0004510_myositis | 1.45244717 |
49 | MP0000689_abnormal_spleen_morphology | 1.44501161 |
50 | MP0010155_abnormal_intestine_physiology | 1.38927951 |
51 | MP0002429_abnormal_blood_cell | 1.38198339 |
52 | MP0009840_abnormal_foam_cell | 1.33190794 |
53 | MP0004185_abnormal_adipocyte_glucose | 1.32229794 |
54 | MP0002138_abnormal_hepatobiliary_system | 1.31511050 |
55 | MP0003191_abnormal_cellular_cholesterol | 1.24414457 |
56 | MP0005410_abnormal_fertilization | 1.19417126 |
57 | MP0005666_abnormal_adipose_tissue | 1.14206005 |
58 | MP0000604_amyloidosis | 1.13084962 |
59 | MP0001533_abnormal_skeleton_physiology | 1.12525446 |
60 | MP0003221_abnormal_cardiomyocyte_apopto | 1.12467500 |
61 | MP0003453_abnormal_keratinocyte_physiol | 1.09239991 |
62 | MP0003329_amyloid_beta_deposits | 1.07753061 |
63 | MP0001845_abnormal_inflammatory_respons | 1.07145751 |
64 | MP0004264_abnormal_extraembryonic_tissu | 1.06169369 |
65 | MP0008004_abnormal_stomach_pH | 1.05315104 |
66 | MP0003111_abnormal_nucleus_morphology | 1.04415912 |
67 | MP0006082_CNS_inflammation | 1.04366665 |
68 | MP0000015_abnormal_ear_pigmentation | 1.02571276 |
69 | MP0005409_darkened_coat_color | 1.00719236 |
70 | MP0008961_abnormal_basal_metabolism | 0.97377783 |
71 | MP0003045_fibrosis | 0.97159185 |
72 | MP0008469_abnormal_protein_level | 0.95796271 |
73 | MP0001348_abnormal_lacrimal_gland | 0.95233966 |
74 | MP0008058_abnormal_DNA_repair | 0.95023091 |
75 | MP0002166_altered_tumor_susceptibility | 0.93888963 |
76 | MP0009115_abnormal_fat_cell | 0.92489759 |
77 | MP0000313_abnormal_cell_death | 0.90279068 |
78 | MP0005375_adipose_tissue_phenotype | 0.89235055 |
79 | MP0002132_abnormal_respiratory_system | 0.88640794 |
80 | MP0001853_heart_inflammation | 0.88348788 |
81 | MP0001929_abnormal_gametogenesis | 0.87627391 |
82 | MP0002998_abnormal_bone_remodeling | 0.86991267 |
83 | MP0008995_early_reproductive_senescence | 0.85176335 |
84 | MP0009764_decreased_sensitivity_to | 0.83188160 |
85 | MP0001851_eye_inflammation | 0.82722581 |
86 | MP0002971_abnormal_brown_adipose | 0.80757250 |
87 | MP0003075_altered_response_to | 0.80015823 |
88 | MP0003866_abnormal_defecation | 0.78866058 |
89 | MP0004233_abnormal_muscle_weight | 0.78457690 |
90 | MP0003077_abnormal_cell_cycle | 0.77686425 |
91 | MP0000465_gastrointestinal_hemorrhage | 0.75302453 |
92 | MP0005621_abnormal_cell_physiology | 0.74926644 |
93 | MP0002019_abnormal_tumor_incidence | 0.74696061 |
94 | MP0003879_abnormal_hair_cell | 0.74610381 |
95 | MP0008874_decreased_physiological_sensi | 0.72649563 |
96 | MP0002970_abnormal_white_adipose | 0.71125292 |
97 | MP0003091_abnormal_cell_migration | 0.71095904 |
98 | MP0003646_muscle_fatigue | 0.70103303 |
99 | MP0003690_abnormal_glial_cell | 0.69950369 |
100 | MP0010352_gastrointestinal_tract_polyps | 0.69372877 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Eczematoid dermatitis (HP:0000976) | 3.95978565 |
2 | Recurrent bacterial skin infections (HP:0005406) | 3.74284372 |
3 | Recurrent abscess formation (HP:0002722) | 3.68171882 |
4 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 3.60631103 |
5 | Slow saccadic eye movements (HP:0000514) | 3.44829991 |
6 | Abnormality of the fingertips (HP:0001211) | 3.44712747 |
7 | Abnormality of macrophages (HP:0004311) | 3.36317958 |
8 | Gastrointestinal inflammation (HP:0004386) | 3.21094198 |
9 | Myositis (HP:0100614) | 3.20088976 |
10 | Prolonged bleeding time (HP:0003010) | 3.19827723 |
11 | Inflammation of the large intestine (HP:0002037) | 3.19493835 |
12 | Colitis (HP:0002583) | 3.11898408 |
13 | Petechiae (HP:0000967) | 2.95849412 |
14 | Increased IgE level (HP:0003212) | 2.90115437 |
15 | Orchitis (HP:0100796) | 2.89473125 |
16 | Spontaneous hematomas (HP:0007420) | 2.82599643 |
17 | Fatigue (HP:0012378) | 2.74504655 |
18 | Increased serum ferritin (HP:0003281) | 2.71821825 |
19 | Recurrent fungal infections (HP:0002841) | 2.69980456 |
20 | Hypochromic anemia (HP:0001931) | 2.69336608 |
21 | Stomatitis (HP:0010280) | 2.66312588 |
22 | Retrobulbar optic neuritis (HP:0100654) | 2.63432247 |
23 | Optic neuritis (HP:0100653) | 2.63432247 |
24 | Cellulitis (HP:0100658) | 2.61446112 |
25 | Asymmetric septal hypertrophy (HP:0001670) | 2.61312334 |
26 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.60868750 |
27 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 2.55941474 |
28 | Hypochromic microcytic anemia (HP:0004840) | 2.53533447 |
29 | Polycythemia (HP:0001901) | 2.51892258 |
30 | Deep palmar crease (HP:0006191) | 2.51354725 |
31 | Obstructive lung disease (HP:0006536) | 2.50195818 |
32 | Chronic obstructive pulmonary disease (HP:0006510) | 2.50195818 |
33 | Autoimmune hemolytic anemia (HP:0001890) | 2.49514182 |
34 | Mediastinal lymphadenopathy (HP:0100721) | 2.48811223 |
35 | Gingivitis (HP:0000230) | 2.46978684 |
36 | Obstructive sleep apnea (HP:0002870) | 2.46457785 |
37 | Vasculitis (HP:0002633) | 2.46188199 |
38 | Heterotopia (HP:0002282) | 2.45940214 |
39 | Severe visual impairment (HP:0001141) | 2.42325669 |
40 | Distal lower limb amyotrophy (HP:0008944) | 2.42289334 |
41 | Meningitis (HP:0001287) | 2.42216400 |
42 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.38802329 |
43 | Gastrointestinal infarctions (HP:0005244) | 2.38554809 |
44 | Sparse lateral eyebrow (HP:0005338) | 2.35235526 |
45 | Abnormality of iron homeostasis (HP:0011031) | 2.31416971 |
46 | Chest pain (HP:0100749) | 2.29563815 |
47 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.27854843 |
48 | Epistaxis (HP:0000421) | 2.27439934 |
49 | Macroorchidism (HP:0000053) | 2.26811994 |
50 | Disinhibition (HP:0000734) | 2.26031970 |
51 | Exercise-induced myalgia (HP:0003738) | 2.22523293 |
52 | Resting tremor (HP:0002322) | 2.22023299 |
53 | Gastrointestinal stroma tumor (HP:0100723) | 2.19581637 |
54 | Urticaria (HP:0001025) | 2.19001448 |
55 | Reticulocytosis (HP:0001923) | 2.18341471 |
56 | Neuronal loss in central nervous system (HP:0002529) | 2.18180678 |
57 | Gingival bleeding (HP:0000225) | 2.15951529 |
58 | Loss of speech (HP:0002371) | 2.15800221 |
59 | Recurrent skin infections (HP:0001581) | 2.15668499 |
60 | Truncal obesity (HP:0001956) | 2.15110919 |
61 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.11767186 |
62 | Abnormality of transition element cation homeostasis (HP:0011030) | 2.10634795 |
63 | Recurrent viral infections (HP:0004429) | 2.07212368 |
64 | Osteomyelitis (HP:0002754) | 2.06872208 |
65 | Nasal polyposis (HP:0100582) | 2.06613227 |
66 | Abnormal large intestine physiology (HP:0012700) | 2.04851773 |
67 | Acute myeloid leukemia (HP:0004808) | 2.04797823 |
68 | Hyperkalemia (HP:0002153) | 2.04320370 |
69 | Encephalitis (HP:0002383) | 2.02655446 |
70 | Bowel incontinence (HP:0002607) | 2.02120604 |
71 | Microcytic anemia (HP:0001935) | 2.01011932 |
72 | Menstrual irregularities (HP:0000858) | 1.99457052 |
73 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 1.95814261 |
74 | Chronic mucocutaneous candidiasis (HP:0002728) | 1.89630359 |
75 | Recurrent cutaneous fungal infections (HP:0011370) | 1.89630359 |
76 | Autoimmune thrombocytopenia (HP:0001973) | 1.88836514 |
77 | Poor eye contact (HP:0000817) | 1.88552707 |
78 | Granulocytopenia (HP:0001913) | 1.88466738 |
79 | Abnormality of glycolipid metabolism (HP:0010969) | 1.87252045 |
80 | Abnormality of liposaccharide metabolism (HP:0010968) | 1.87252045 |
81 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 1.87252045 |
82 | Distal lower limb muscle weakness (HP:0009053) | 1.86570376 |
83 | Episodic fever (HP:0001954) | 1.85858471 |
84 | Keratoconjunctivitis sicca (HP:0001097) | 1.82359237 |
85 | Stomach cancer (HP:0012126) | 1.81748816 |
86 | Pustule (HP:0200039) | 1.80352098 |
87 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 1.79324538 |
88 | Panhypogammaglobulinemia (HP:0003139) | 1.76772791 |
89 | Hemoptysis (HP:0002105) | 1.75066468 |
90 | Lymphopenia (HP:0001888) | 1.75012999 |
91 | Decreased motor nerve conduction velocity (HP:0003431) | 1.74328479 |
92 | Amelogenesis imperfecta (HP:0000705) | 1.74291369 |
93 | Abnormality of the periventricular white matter (HP:0002518) | 1.73083619 |
94 | Lip pit (HP:0100267) | 1.71002828 |
95 | Abnormality of the endocardium (HP:0004306) | 1.69848998 |
96 | Impaired platelet aggregation (HP:0003540) | 1.67798173 |
97 | Abnormal platelet function (HP:0011869) | 1.67798173 |
98 | Dysostosis multiplex (HP:0000943) | 1.67651556 |
99 | Malnutrition (HP:0004395) | 1.66562236 |
100 | Purpura (HP:0000979) | 1.65537320 |
Rank | Gene Set | Z-score |
---|---|---|
1 | RIPK4 | 3.58522908 |
2 | CDK12 | 3.10984479 |
3 | PRPF4B | 2.98594923 |
4 | MAP3K10 | 2.98026790 |
5 | ERN1 | 2.42209998 |
6 | TRIB3 | 2.36006317 |
7 | MAP2K3 | 2.29791961 |
8 | MAP4K1 | 2.08459412 |
9 | TAOK1 | 2.03046627 |
10 | MARK2 | 1.85490268 |
11 | IRAK4 | 1.82158797 |
12 | AKT3 | 1.79489638 |
13 | RIPK1 | 1.78896901 |
14 | KSR2 | 1.69298359 |
15 | BLK | 1.66478140 |
16 | ZAP70 | 1.60875696 |
17 | ICK | 1.58828945 |
18 | MAP3K13 | 1.51890877 |
19 | SIK3 | 1.47890696 |
20 | MAP3K1 | 1.47661298 |
21 | MAP3K3 | 1.47216215 |
22 | BRD4 | 1.45660246 |
23 | TYK2 | 1.41745477 |
24 | STK38 | 1.38476187 |
25 | CDK9 | 1.38243521 |
26 | WNK1 | 1.33468627 |
27 | SGK3 | 1.33271928 |
28 | IRAK3 | 1.32605021 |
29 | PRKD2 | 1.31058872 |
30 | SIK2 | 1.30852534 |
31 | BTK | 1.27383435 |
32 | MAP3K14 | 1.25478328 |
33 | BRAF | 1.23622379 |
34 | TNK2 | 1.23514727 |
35 | TBK1 | 1.20662938 |
36 | CSK | 1.19806179 |
37 | FES | 1.17644786 |
38 | EPHB1 | 1.15604571 |
39 | SYK | 1.15407243 |
40 | SIK1 | 1.14790841 |
41 | TAOK2 | 1.13838921 |
42 | YES1 | 1.13593764 |
43 | JAK3 | 1.13236760 |
44 | MAP3K11 | 1.12847874 |
45 | SMG1 | 1.12372524 |
46 | PDK1 | 1.11802876 |
47 | MAP3K2 | 1.08640956 |
48 | MARK3 | 1.08290931 |
49 | HIPK2 | 1.07542478 |
50 | IKBKE | 1.06370962 |
51 | HCK | 1.06165660 |
52 | GRK6 | 1.05390377 |
53 | PDPK1 | 1.01530252 |
54 | FGR | 1.00374056 |
55 | MAPK11 | 0.99643459 |
56 | SGK2 | 0.99632118 |
57 | JAK2 | 0.97884666 |
58 | TAOK3 | 0.97617270 |
59 | CSF1R | 0.92213600 |
60 | TESK2 | 0.91441994 |
61 | CAMK1D | 0.90222895 |
62 | IKBKB | 0.89061475 |
63 | CAMK1G | 0.88285492 |
64 | NLK | 0.85232757 |
65 | EPHA3 | 0.78345347 |
66 | IRAK1 | 0.78310758 |
67 | CDK4 | 0.78188149 |
68 | MAPK7 | 0.76496473 |
69 | PIM1 | 0.76368829 |
70 | MTOR | 0.74432710 |
71 | PIK3CG | 0.73619309 |
72 | MAP2K2 | 0.71956213 |
73 | CAMK4 | 0.71623465 |
74 | FGFR3 | 0.71020409 |
75 | BMX | 0.67418400 |
76 | CDC42BPA | 0.66668959 |
77 | RET | 0.66153656 |
78 | MAPK12 | 0.63620216 |
79 | ITK | 0.63393533 |
80 | CDK19 | 0.63263124 |
81 | MAP3K7 | 0.61725325 |
82 | RAF1 | 0.61228675 |
83 | MATK | 0.60558949 |
84 | LYN | 0.58693746 |
85 | RPS6KL1 | 0.58102767 |
86 | RPS6KC1 | 0.58102767 |
87 | IRAK2 | 0.57436283 |
88 | TEC | 0.55344941 |
89 | BMPR2 | 0.55050290 |
90 | LCK | 0.54220655 |
91 | PDGFRB | 0.53816346 |
92 | SGK223 | 0.53188315 |
93 | SGK494 | 0.53188315 |
94 | KSR1 | 0.53062041 |
95 | FGFR4 | 0.50254805 |
96 | RPS6KA6 | 0.48767722 |
97 | MAPK3 | 0.47543283 |
98 | CDK8 | 0.46911125 |
99 | CDK7 | 0.46629260 |
100 | MAP3K8 | 0.45192968 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 2.44516714 |
2 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 2.37820864 |
3 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.22649677 |
4 | Leishmaniasis_Homo sapiens_hsa05140 | 1.91783638 |
5 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.88430444 |
6 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 1.83056164 |
7 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.82086479 |
8 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.74132080 |
9 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.72998059 |
10 | Influenza A_Homo sapiens_hsa05164 | 1.71455877 |
11 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.64750078 |
12 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.60994850 |
13 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.55179033 |
14 | Hepatitis B_Homo sapiens_hsa05161 | 1.51788939 |
15 | Allograft rejection_Homo sapiens_hsa05330 | 1.51215907 |
16 | Tuberculosis_Homo sapiens_hsa05152 | 1.51194350 |
17 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.49972582 |
18 | Measles_Homo sapiens_hsa05162 | 1.49026473 |
19 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.48530093 |
20 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.45719376 |
21 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.41923502 |
22 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.41622569 |
23 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.41365444 |
24 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.37689908 |
25 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.37543600 |
26 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.36714969 |
27 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.34367604 |
28 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.32312228 |
29 | VEGF signaling pathway_Homo sapiens_hsa04370 | 1.29794467 |
30 | Renal cell carcinoma_Homo sapiens_hsa05211 | 1.28868894 |
31 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 1.25489613 |
32 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.24412115 |
33 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 1.23977287 |
34 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.23948085 |
35 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.23746275 |
36 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.21912899 |
37 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.20099511 |
38 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.19567194 |
39 | Viral myocarditis_Homo sapiens_hsa05416 | 1.17441312 |
40 | Endometrial cancer_Homo sapiens_hsa05213 | 1.15539670 |
41 | Hepatitis C_Homo sapiens_hsa05160 | 1.15166215 |
42 | Other glycan degradation_Homo sapiens_hsa00511 | 1.11495525 |
43 | Apoptosis_Homo sapiens_hsa04210 | 1.11389250 |
44 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.09552877 |
45 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.09124912 |
46 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 1.08678734 |
47 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.08541577 |
48 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.04580596 |
49 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.03164755 |
50 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.03153650 |
51 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.02740941 |
52 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.99363183 |
53 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.98129807 |
54 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.97188349 |
55 | Legionellosis_Homo sapiens_hsa05134 | 0.96526084 |
56 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.94256446 |
57 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.93841712 |
58 | Endocytosis_Homo sapiens_hsa04144 | 0.93808273 |
59 | Glioma_Homo sapiens_hsa05214 | 0.92640040 |
60 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.91664154 |
61 | Prostate cancer_Homo sapiens_hsa05215 | 0.91553345 |
62 | Bladder cancer_Homo sapiens_hsa05219 | 0.91401762 |
63 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.91110366 |
64 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.90390062 |
65 | Thyroid cancer_Homo sapiens_hsa05216 | 0.89636168 |
66 | Platelet activation_Homo sapiens_hsa04611 | 0.86765497 |
67 | Malaria_Homo sapiens_hsa05144 | 0.86423280 |
68 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.85424493 |
69 | Colorectal cancer_Homo sapiens_hsa05210 | 0.85291648 |
70 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.82816399 |
71 | Alcoholism_Homo sapiens_hsa05034 | 0.82764519 |
72 | HTLV-I infection_Homo sapiens_hsa05166 | 0.82691334 |
73 | Asthma_Homo sapiens_hsa05310 | 0.82405967 |
74 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.81743360 |
75 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.81177444 |
76 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.81040206 |
77 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.80869018 |
78 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.80110297 |
79 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.78813322 |
80 | Insulin resistance_Homo sapiens_hsa04931 | 0.77358373 |
81 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.76737852 |
82 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.75079865 |
83 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.74844242 |
84 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.73759173 |
85 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.73443806 |
86 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.73187623 |
87 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.73028119 |
88 | Long-term potentiation_Homo sapiens_hsa04720 | 0.68759621 |
89 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.65910031 |
90 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.65061244 |
91 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.62790889 |
92 | Lysosome_Homo sapiens_hsa04142 | 0.61149385 |
93 | Pertussis_Homo sapiens_hsa05133 | 0.59366525 |
94 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.57024139 |
95 | Phagosome_Homo sapiens_hsa04145 | 0.56682034 |
96 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.54694907 |
97 | Shigellosis_Homo sapiens_hsa05131 | 0.50631474 |
98 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.48589160 |
99 | Lysine degradation_Homo sapiens_hsa00310 | 0.47679442 |
100 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.47568161 |