YY2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transcription factor that includes several Kruppel-like zinc fingers in its C-terminal region. It possesses both activation and repression domains, and it can therefore have both positive and negative effects on the transcription of target genes. This gene has an intronless coding region, and it appears to have arisen by retrotransposition of the related YY1 transcription factor gene, which is located on chromosome 14. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)6.08565492
2synapsis (GO:0007129)5.85994344
3metaphase plate congression (GO:0051310)5.25973554
4regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.03165974
5purine nucleobase biosynthetic process (GO:0009113)4.89732972
6histone H2A acetylation (GO:0043968)4.87757503
7chromosome organization involved in meiosis (GO:0070192)4.60757564
8protein localization to kinetochore (GO:0034501)4.59643257
9negative regulation of meiosis (GO:0045835)4.58681361
10DNA replication checkpoint (GO:0000076)4.57794070
11maturation of 5.8S rRNA (GO:0000460)4.51229315
12establishment of chromosome localization (GO:0051303)4.50234881
13inner cell mass cell proliferation (GO:0001833)4.47751860
14meiotic chromosome segregation (GO:0045132)4.40039384
15regulation of spindle organization (GO:0090224)4.36685531
16nucleobase biosynthetic process (GO:0046112)4.30786041
17DNA methylation involved in gamete generation (GO:0043046)4.28893415
18nuclear pore organization (GO:0006999)4.20972559
19positive regulation of meiosis (GO:0045836)4.18263931
20DNA replication-dependent nucleosome organization (GO:0034723)4.17547504
21DNA replication-dependent nucleosome assembly (GO:0006335)4.17547504
22attachment of spindle microtubules to kinetochore (GO:0008608)4.15715770
23nuclear pore complex assembly (GO:0051292)4.12781014
24regulation of meiosis I (GO:0060631)4.10253571
25chromatin remodeling at centromere (GO:0031055)4.03541361
26CENP-A containing nucleosome assembly (GO:0034080)4.02345543
27pteridine-containing compound biosynthetic process (GO:0042559)4.02183944
28spindle checkpoint (GO:0031577)3.99971592
29proteasome assembly (GO:0043248)3.96622458
30synaptonemal complex assembly (GO:0007130)3.96415017
31protein localization to chromosome, centromeric region (GO:0071459)3.95622140
32regulation of centriole replication (GO:0046599)3.93276390
33DNA replication initiation (GO:0006270)3.84839151
34positive regulation of meiotic cell cycle (GO:0051446)3.83620064
35DNA replication-independent nucleosome assembly (GO:0006336)3.82621010
36DNA replication-independent nucleosome organization (GO:0034724)3.82621010
37mitotic nuclear envelope disassembly (GO:0007077)3.81326511
38gene silencing by RNA (GO:0031047)3.80979648
39regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.80961974
40regulation of double-strand break repair via homologous recombination (GO:0010569)3.79852422
41monoubiquitinated protein deubiquitination (GO:0035520)3.79548947
42microtubule depolymerization (GO:0007019)3.78630972
43regulation of chromosome segregation (GO:0051983)3.78193547
44histone exchange (GO:0043486)3.73843561
45protein K6-linked ubiquitination (GO:0085020)3.73146767
46male meiosis (GO:0007140)3.71066167
47kinetochore organization (GO:0051383)3.68576873
48mitotic spindle checkpoint (GO:0071174)3.66544065
49DNA synthesis involved in DNA repair (GO:0000731)3.66411025
50spindle assembly checkpoint (GO:0071173)3.65649992
51transcription from mitochondrial promoter (GO:0006390)3.64859291
52mitotic chromosome condensation (GO:0007076)3.64293090
53mitotic spindle assembly checkpoint (GO:0007094)3.63281102
54negative regulation of mitotic sister chromatid separation (GO:2000816)3.57887011
55negative regulation of mitotic sister chromatid segregation (GO:0033048)3.57887011
56negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.57887011
57negative regulation of sister chromatid segregation (GO:0033046)3.57887011
58negative regulation of chromosome segregation (GO:0051985)3.57169877
59membrane disassembly (GO:0030397)3.54676759
60nuclear envelope disassembly (GO:0051081)3.54676759
61regulation of mitotic metaphase/anaphase transition (GO:0030071)3.54676173
62regulation of mitotic spindle organization (GO:0060236)3.53681639
63regulation of telomere maintenance via telomerase (GO:0032210)3.52593022
64ribosome biogenesis (GO:0042254)3.51910226
65protein localization to chromosome (GO:0034502)3.49725005
66kinetochore assembly (GO:0051382)3.49015240
67synaptonemal complex organization (GO:0070193)3.48830418
68negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.48768313
69positive regulation of chromosome segregation (GO:0051984)3.48573376
70regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.47702881
71regulation of sister chromatid cohesion (GO:0007063)3.42437459
72resolution of meiotic recombination intermediates (GO:0000712)3.41331298
73ribosome assembly (GO:0042255)3.38297510
74regulation of sister chromatid segregation (GO:0033045)3.35713572
75regulation of mitotic sister chromatid separation (GO:0010965)3.35713572
76regulation of mitotic sister chromatid segregation (GO:0033047)3.35713572
77cullin deneddylation (GO:0010388)3.34923037
78regulation of transcription from RNA polymerase I promoter (GO:0006356)3.33856794
79mitotic sister chromatid segregation (GO:0000070)3.33476615
80chromosome segregation (GO:0007059)3.33016272
81pore complex assembly (GO:0046931)3.31997440
82IMP biosynthetic process (GO:0006188)3.31656812
83regulation of exit from mitosis (GO:0007096)3.31054284
84regulation of helicase activity (GO:0051095)3.30126257
85mitotic recombination (GO:0006312)3.27506136
86response to UV-C (GO:0010225)3.27006732
87meiosis I (GO:0007127)3.25877102
88piRNA metabolic process (GO:0034587)3.25315553
89reciprocal DNA recombination (GO:0035825)3.25111626
90reciprocal meiotic recombination (GO:0007131)3.25111626
91germ cell migration (GO:0008354)3.23013830
92regulation of nuclear cell cycle DNA replication (GO:0033262)3.21342856
93telomere maintenance via recombination (GO:0000722)3.20678100
94sister chromatid segregation (GO:0000819)3.18079512
95chromatin assembly or disassembly (GO:0006333)3.16647257
96histone H2A monoubiquitination (GO:0035518)3.16062669
97DNA unwinding involved in DNA replication (GO:0006268)3.15575880
98mitotic sister chromatid cohesion (GO:0007064)3.15360509
99male meiosis I (GO:0007141)3.14557604
100DNA strand elongation involved in DNA replication (GO:0006271)3.14084808
101maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.12733708
102meiotic cell cycle process (GO:1903046)3.12682668
103nucleotide-excision repair, DNA gap filling (GO:0006297)3.12363313
104mitochondrial RNA metabolic process (GO:0000959)3.11509243
105negative regulation of meiotic cell cycle (GO:0051447)3.09845003
106regulation of translation in response to stress (GO:0043555)3.08427005
107positive regulation of male gonad development (GO:2000020)3.07954272
108telomere maintenance via semi-conservative replication (GO:0032201)3.05936651
109sister chromatid cohesion (GO:0007062)3.05934695
110positive regulation of mitotic sister chromatid separation (GO:1901970)3.04736933
111positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.04736933
112positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.04736933
113regulation of RNA export from nucleus (GO:0046831)3.04410378
114telomere maintenance via telomere lengthening (GO:0010833)3.04174895
115regulation of centrosome cycle (GO:0046605)3.03676277
116negative regulation of DNA-dependent DNA replication (GO:2000104)3.03016571
117folic acid-containing compound biosynthetic process (GO:0009396)3.02255999
118lactate metabolic process (GO:0006089)3.01876751
119meiotic nuclear division (GO:0007126)3.01717936
120regulation of DNA endoreduplication (GO:0032875)3.01326639
121DNA strand elongation (GO:0022616)2.98575864
122binding of sperm to zona pellucida (GO:0007339)2.97885858
123replication fork processing (GO:0031297)2.96235595
124protein deneddylation (GO:0000338)2.95626109
125female gamete generation (GO:0007292)2.90510297
126maturation of SSU-rRNA (GO:0030490)2.90196213
127DNA double-strand break processing (GO:0000729)2.89352105
128peptidyl-histidine modification (GO:0018202)2.89171340
129oogenesis (GO:0048477)2.89111643
130regulation of meiosis (GO:0040020)2.87691407
131double-strand break repair via homologous recombination (GO:0000724)2.86899711
132ATP-dependent chromatin remodeling (GO:0043044)2.86877650
133postreplication repair (GO:0006301)2.81867032
134DNA-dependent DNA replication (GO:0006261)2.80874557
135recombinational repair (GO:0000725)2.80446473
136double-strand break repair via nonhomologous end joining (GO:0006303)2.79805323
137non-recombinational repair (GO:0000726)2.79805323
138ubiquinone biosynthetic process (GO:0006744)2.77591132
139positive regulation of histone H3-K4 methylation (GO:0051571)2.77330405
140oocyte development (GO:0048599)2.77141197
141pseudouridine synthesis (GO:0001522)2.76175685
142regulation of centrosome duplication (GO:0010824)2.74680365
143spindle assembly involved in mitosis (GO:0090307)2.74363922
144transcription elongation from RNA polymerase I promoter (GO:0006362)2.72527839
145translesion synthesis (GO:0019985)2.72331725
146double-strand break repair (GO:0006302)2.70689685
147DNA catabolic process, exonucleolytic (GO:0000738)2.70504941
148nucleotide transmembrane transport (GO:1901679)2.70062464
149pteridine-containing compound metabolic process (GO:0042558)2.69609702
150methionine metabolic process (GO:0006555)2.69587048
151somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.67816298
152isotype switching (GO:0045190)2.67816298

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.76729111
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.20044721
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.23615786
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.56035043
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.54806668
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.36321711
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.80515247
8AR_21909140_ChIP-Seq_LNCAP_Human2.80376015
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.75841371
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.65260312
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.64261358
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.53765860
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.52443936
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.49535300
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.46336253
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.42722489
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.33631157
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.33366444
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.29899930
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27092254
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.23478643
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.22335131
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.19470694
24VDR_23849224_ChIP-Seq_CD4+_Human2.15060913
25HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.13201962
26GATA1_22025678_ChIP-Seq_K562_Human2.11650174
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.08518074
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.07645613
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.00151323
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.98138101
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.89852782
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88508505
33XRN2_22483619_ChIP-Seq_HELA_Human1.80473750
34FOXP3_21729870_ChIP-Seq_TREG_Human1.77097959
35ELK1_19687146_ChIP-ChIP_HELA_Human1.75802321
36RBPJ_22232070_ChIP-Seq_NCS_Mouse1.75334137
37FUS_26573619_Chip-Seq_HEK293_Human1.70556718
38ZNF263_19887448_ChIP-Seq_K562_Human1.63340191
39GABP_19822575_ChIP-Seq_HepG2_Human1.62517545
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.62107884
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62092413
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60538074
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59355766
44EWS_26573619_Chip-Seq_HEK293_Human1.58372599
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57984162
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.54578459
47DCP1A_22483619_ChIP-Seq_HELA_Human1.52071279
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49294370
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.48185454
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45755440
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.43897606
52CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.42102271
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41131785
54TTF2_22483619_ChIP-Seq_HELA_Human1.39365627
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34300449
56HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.33830007
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31789239
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.29202423
59KDM5A_27292631_Chip-Seq_BREAST_Human1.28273798
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26020820
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24243411
62KAP1_22055183_ChIP-Seq_ESCs_Mouse1.22020391
63MYC_22102868_ChIP-Seq_BL_Human1.19716467
64* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18688729
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18553781
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.17686304
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17503684
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13661109
69MYC_18940864_ChIP-ChIP_HL60_Human1.13341203
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12305857
71E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11113405
72STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08519709
73ELF1_17652178_ChIP-ChIP_JURKAT_Human1.08231927
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08120907
75CIITA_25753668_ChIP-Seq_RAJI_Human1.05377228
76SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04073989
77RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02729367
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02574366
79SPI1_23547873_ChIP-Seq_NB4_Human1.02112493
80HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01823616
81SRF_21415370_ChIP-Seq_HL-1_Mouse1.01395008
82SMAD_19615063_ChIP-ChIP_OVARY_Human1.00341069
83NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98775520
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98675174
85THAP11_20581084_ChIP-Seq_MESCs_Mouse0.96129388
86POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95214912
87IRF8_21731497_ChIP-ChIP_J774_Mouse0.94512310
88SOX17_20123909_ChIP-Seq_XEN_Mouse0.92821610
89ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92804237
90TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91614870
91PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91456403
92ZNF274_21170338_ChIP-Seq_K562_Hela0.91107336
93NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91099937
94ELF5_23300383_ChIP-Seq_T47D_Human0.90865397
95YY1_21170310_ChIP-Seq_MESCs_Mouse0.90397434
96ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89927319
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.89678281
98ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88014377
99TFEB_21752829_ChIP-Seq_HELA_Human0.87703532
100IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.85924816
101TBX5_21415370_ChIP-Seq_HL-1_Mouse0.82719650
102GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82540543
103SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82149444
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.80823993
105ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.79929280
106BRD4_25478319_ChIP-Seq_HGPS_Human0.79562292
107SOX2_18555785_ChIP-Seq_MESCs_Mouse0.78885012
108MYB_26560356_Chip-Seq_TH2_Human0.78394743
109BP1_19119308_ChIP-ChIP_Hs578T_Human0.77887490
110ER_23166858_ChIP-Seq_MCF-7_Human0.77638651
111CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.76453098
112RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76359404
113ELK1_22589737_ChIP-Seq_MCF10A_Human0.76113802
114FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.74444256
115CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.74273263
116TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.73899516
117MYB_21317192_ChIP-Seq_ERMYB_Mouse0.73361841
118SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.73099733
119IGF1R_20145208_ChIP-Seq_DFB_Human0.72778983
120MYB_26560356_Chip-Seq_TH1_Human0.71748172
121EZH2_27294783_Chip-Seq_NPCs_Mouse0.71270224
122PKCTHETA_26484144_Chip-Seq_BREAST_Human0.71051647
123PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.70281849
124SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.70004485
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.69701143
126GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.69629316
127FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.69142908
128CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.68925407
129TP53_22573176_ChIP-Seq_HFKS_Human0.68413819
130GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.67439905
131VDR_22108803_ChIP-Seq_LS180_Human0.67253137
132TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.66734432
133CBP_20019798_ChIP-Seq_JUKART_Human0.65515667

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.45322907
2MP0003111_abnormal_nucleus_morphology4.47117193
3MP0010094_abnormal_chromosome_stability4.09066946
4MP0008057_abnormal_DNA_replication3.95828770
5MP0008877_abnormal_DNA_methylation3.90670053
6MP0003077_abnormal_cell_cycle3.65253164
7MP0008058_abnormal_DNA_repair3.49999614
8MP0004957_abnormal_blastocyst_morpholog3.45939409
9MP0000372_irregular_coat_pigmentation3.14336301
10MP0003950_abnormal_plasma_membrane3.14130327
11MP0002396_abnormal_hematopoietic_system2.94644755
12MP0008007_abnormal_cellular_replicative2.83352525
13MP0010307_abnormal_tumor_latency2.71487065
14MP0008995_early_reproductive_senescence2.57476843
15MP0002877_abnormal_melanocyte_morpholog2.55144197
16MP0003786_premature_aging2.45827099
17MP0010386_abnormal_urinary_bladder2.45092826
18MP0003890_abnormal_embryonic-extraembry2.44368052
19MP0001730_embryonic_growth_arrest2.36763327
20MP0010352_gastrointestinal_tract_polyps2.33450804
21MP0003718_maternal_effect2.22594583
22MP0003123_paternal_imprinting2.16803478
23MP0000350_abnormal_cell_proliferation2.11550322
24MP0008932_abnormal_embryonic_tissue2.10036472
25MP0005174_abnormal_tail_pigmentation1.99881617
26MP0006035_abnormal_mitochondrial_morpho1.87587575
27MP0002210_abnormal_sex_determination1.83190016
28MP0000015_abnormal_ear_pigmentation1.79730338
29MP0001672_abnormal_embryogenesis/_devel1.69420458
30MP0005380_embryogenesis_phenotype1.69420458
31MP0004808_abnormal_hematopoietic_stem1.66412710
32MP0006292_abnormal_olfactory_placode1.65766882
33MP0001697_abnormal_embryo_size1.60327037
34MP0000358_abnormal_cell_content/1.59723454
35MP0003303_peritoneal_inflammation1.59250154
36MP0010234_abnormal_vibrissa_follicle1.52024511
37MP0000427_abnormal_hair_cycle1.46710002
38MP0003984_embryonic_growth_retardation1.45946345
39MP0005084_abnormal_gallbladder_morpholo1.45562910
40MP0001145_abnormal_male_reproductive1.45498788
41MP0002086_abnormal_extraembryonic_tissu1.43939748
42MP0001545_abnormal_hematopoietic_system1.43159870
43MP0005397_hematopoietic_system_phenotyp1.43159870
44MP0002102_abnormal_ear_morphology1.42253080
45MP0002088_abnormal_embryonic_growth/wei1.41917319
46MP0000653_abnormal_sex_gland1.37357231
47MP0001929_abnormal_gametogenesis1.35598552
48MP0009333_abnormal_splenocyte_physiolog1.34981967
49MP0000490_abnormal_crypts_of1.34110875
50MP0002080_prenatal_lethality1.30886749
51MP0005187_abnormal_penis_morphology1.30443248
52MP0006036_abnormal_mitochondrial_physio1.29968991
53MP0001119_abnormal_female_reproductive1.29774271
54MP0002019_abnormal_tumor_incidence1.29511629
55MP0010678_abnormal_skin_adnexa1.28850471
56MP0002085_abnormal_embryonic_tissue1.28369381
57MP0002084_abnormal_developmental_patter1.26245215
58MP0005076_abnormal_cell_differentiation1.26225353
59MP0003567_abnormal_fetal_cardiomyocyte1.26075927
60MP0000371_diluted_coat_color1.24697096
61MP0004197_abnormal_fetal_growth/weight/1.23836821
62MP0000465_gastrointestinal_hemorrhage1.20074850
63MP0003448_altered_tumor_morphology1.19751835
64MP0003121_genomic_imprinting1.18136423
65MP0000313_abnormal_cell_death1.17371357
66MP0002095_abnormal_skin_pigmentation1.13371953
67MP0002398_abnormal_bone_marrow1.13109899
68MP0004147_increased_porphyrin_level1.09193457
69MP0005671_abnormal_response_to1.09114884
70MP0002006_tumorigenesis1.08705288
71MP0003656_abnormal_erythrocyte_physiolo1.07804579
72MP0005645_abnormal_hypothalamus_physiol1.07090291
73MP0008438_abnormal_cutaneous_collagen1.06325130
74MP0003937_abnormal_limbs/digits/tail_de1.05175607
75MP0001661_extended_life_span1.04867533
76MP0000383_abnormal_hair_follicle1.03071616
77MP0000689_abnormal_spleen_morphology1.02458985
78MP0002722_abnormal_immune_system1.02247964
79MP0002090_abnormal_vision1.01384926
80MP0005379_endocrine/exocrine_gland_phen1.01256487
81MP0001835_abnormal_antigen_presentation0.98036386
82MP0001764_abnormal_homeostasis0.97416480
83MP0005621_abnormal_cell_physiology0.96824090
84MP0001800_abnormal_humoral_immune0.96270534
85MP0003763_abnormal_thymus_physiology0.95612010
86MP0000647_abnormal_sebaceous_gland0.94094622
87MP0003119_abnormal_digestive_system0.93960056
88MP0009672_abnormal_birth_weight0.92174265
89MP0002139_abnormal_hepatobiliary_system0.91962955
90MP0003221_abnormal_cardiomyocyte_apopto0.91783485
91MP0000703_abnormal_thymus_morphology0.90742424
92MP0002177_abnormal_outer_ear0.89369323
93MP0004134_abnormal_chest_morphology0.88528621
94MP0002938_white_spotting0.88280464
95MP0005075_abnormal_melanosome_morpholog0.88090172
96MP0000569_abnormal_digit_pigmentation0.87843694
97MP0003315_abnormal_perineum_morphology0.85570894
98MP0003787_abnormal_imprinting0.85364641
99MP0001186_pigmentation_phenotype0.84464740
100MP0005647_abnormal_sex_gland0.83528893
101MP0004233_abnormal_muscle_weight0.83275370
102MP0002452_abnormal_antigen_presenting0.82762976
103MP0003941_abnormal_skin_development0.81823228
104MP0005410_abnormal_fertilization0.81647907
105MP0000716_abnormal_immune_system0.81329828
106MP0009697_abnormal_copulation0.80550826
107MP0002075_abnormal_coat/hair_pigmentati0.80458305
108MP0005409_darkened_coat_color0.79475096
109MP0003699_abnormal_female_reproductive0.79449994
110MP0008789_abnormal_olfactory_epithelium0.79376801
111MP0005384_cellular_phenotype0.79124995
112MP0008260_abnormal_autophagy0.79095914
113MP0002166_altered_tumor_susceptibility0.78704973
114MP0002429_abnormal_blood_cell0.78416191
115MP0003828_pulmonary_edema0.77697908
116MP0001881_abnormal_mammary_gland0.76536864
117MP0002234_abnormal_pharynx_morphology0.75569782
118MP0003943_abnormal_hepatobiliary_system0.75558856
119MP0002723_abnormal_immune_serum0.74457896
120MP0000538_abnormal_urinary_bladder0.74289593
121MP0003959_abnormal_lean_body0.73539542
122MP0002160_abnormal_reproductive_system0.72957940
123MP0001188_hyperpigmentation0.72808327
124MP0006072_abnormal_retinal_apoptosis0.72210527
125MP0002420_abnormal_adaptive_immunity0.71834595
126MP0010030_abnormal_orbit_morphology0.71808338
127MP0010368_abnormal_lymphatic_system0.71706608
128MP0001819_abnormal_immune_cell0.71453973
129MP0002233_abnormal_nose_morphology0.70993299
130MP0001293_anophthalmia0.70486794
131MP0000627_abnormal_mammary_gland0.70048583
132MP0005389_reproductive_system_phenotype0.69790702
133MP0001216_abnormal_epidermal_layer0.68995819
134MP0002751_abnormal_autonomic_nervous0.66209745
135MP0009780_abnormal_chondrocyte_physiolo0.65777820
136MP0005000_abnormal_immune_tolerance0.64116771
137MP0004084_abnormal_cardiac_muscle0.63407496
138MP0005408_hypopigmentation0.63094650
139MP0000858_altered_metastatic_potential0.62330220
140MP0009278_abnormal_bone_marrow0.61274442
141MP0003936_abnormal_reproductive_system0.61095580
142MP0006054_spinal_hemorrhage0.60618572
143MP0002163_abnormal_gland_morphology0.60590722
144MP0001853_heart_inflammation0.59875639
145MP0005395_other_phenotype0.59339965
146MP0009703_decreased_birth_body0.59032410
147MP0003698_abnormal_male_reproductive0.58538688
148MP0002277_abnormal_respiratory_mucosa0.57836839
149MP0002161_abnormal_fertility/fecundity0.57027072
150MP0005451_abnormal_body_composition0.55654545
151MP0000428_abnormal_craniofacial_morphol0.55341487
152MP0002132_abnormal_respiratory_system0.55220604
153MP0002405_respiratory_system_inflammati0.54803780

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.67059621
2Chromsome breakage (HP:0040012)6.49846426
3Birth length less than 3rd percentile (HP:0003561)5.48444422
4Aplastic anemia (HP:0001915)5.09267295
5Medulloblastoma (HP:0002885)4.59725933
6Abnormality of chromosome stability (HP:0003220)4.34328610
7Intestinal atresia (HP:0011100)4.34084009
8Breast hypoplasia (HP:0003187)4.20660084
9Meckel diverticulum (HP:0002245)4.06457743
10Abnormality of the preputium (HP:0100587)4.00247581
11Aplasia/Hypoplasia of the uvula (HP:0010293)3.85710828
12Abnormality of the ileum (HP:0001549)3.78372639
13Colon cancer (HP:0003003)3.78002231
14Sensory axonal neuropathy (HP:0003390)3.64531066
15Asymmetry of the thorax (HP:0001555)3.46725542
16Carpal bone hypoplasia (HP:0001498)3.42177840
17Patellar aplasia (HP:0006443)3.31372603
18Rough bone trabeculation (HP:0100670)3.31090069
19Abnormal spermatogenesis (HP:0008669)3.28311777
20Small intestinal stenosis (HP:0012848)3.17840744
21Duodenal stenosis (HP:0100867)3.17840744
22Azoospermia (HP:0000027)3.11796480
23Fibular aplasia (HP:0002990)3.08002393
24Aplasia/Hypoplasia of the patella (HP:0006498)3.06177860
25Myelodysplasia (HP:0002863)3.03585859
26Facial hemangioma (HP:0000329)3.02398022
27Complete atrioventricular canal defect (HP:0001674)3.02263925
28Nephroblastoma (Wilms tumor) (HP:0002667)3.01629312
29Facial cleft (HP:0002006)2.99017450
30Abnormality of the labia minora (HP:0012880)2.85281169
31Capillary hemangiomas (HP:0005306)2.82743881
32Prostate neoplasm (HP:0100787)2.80482354
33Agnosia (HP:0010524)2.79218431
34Embryonal renal neoplasm (HP:0011794)2.78971565
35Short thumb (HP:0009778)2.78175258
36Neonatal short-limb short stature (HP:0008921)2.72058990
37Clubbing of toes (HP:0100760)2.71642925
38Septate vagina (HP:0001153)2.66386358
39Impulsivity (HP:0100710)2.65731243
40Supernumerary spleens (HP:0009799)2.63760517
41Gastrointestinal atresia (HP:0002589)2.57757039
42Bone marrow hypocellularity (HP:0005528)2.55300245
43Abnormality of the duodenum (HP:0002246)2.51251367
44Horizontal nystagmus (HP:0000666)2.50915378
45Abnormal trabecular bone morphology (HP:0100671)2.48992573
46Papillary thyroid carcinoma (HP:0002895)2.48152075
47Proximal tubulopathy (HP:0000114)2.46342034
48Abnormality of the fovea (HP:0000493)2.44967688
49Ectopic kidney (HP:0000086)2.44583043
50Oligodactyly (hands) (HP:0001180)2.44469942
51Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.43787700
52Shawl scrotum (HP:0000049)2.41172019
53Acute myeloid leukemia (HP:0004808)2.39246825
54Short tibia (HP:0005736)2.38579520
55Abnormality of the carotid arteries (HP:0005344)2.36706634
56Abnormality of the renal collecting system (HP:0004742)2.36087821
57Abnormality of alanine metabolism (HP:0010916)2.33792977
58Hyperalaninemia (HP:0003348)2.33792977
59Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.33792977
60Wrist flexion contracture (HP:0001239)2.33684490
61Abnormal lung lobation (HP:0002101)2.30944451
62Abnormality of aromatic amino acid family metabolism (HP:0004338)2.30337138
63Cerebral hypomyelination (HP:0006808)2.29889963
64Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.28541312
65Degeneration of the lateral corticospinal tracts (HP:0002314)2.28541312
66Osteomalacia (HP:0002749)2.27990826
67Duplicated collecting system (HP:0000081)2.27042378
68Horseshoe kidney (HP:0000085)2.26520889
69Ependymoma (HP:0002888)2.26127203
70Atrioventricular canal defect (HP:0006695)2.24428841
71Abnormality of the alveolar ridges (HP:0006477)2.23730381
72Anal stenosis (HP:0002025)2.23709343
73Absent radius (HP:0003974)2.20998266
74Breast aplasia (HP:0100783)2.20856748
75Aplasia/Hypoplasia of the tibia (HP:0005772)2.18674107
76Oral leukoplakia (HP:0002745)2.17558012
77Absent thumb (HP:0009777)2.16476767
78Cafe-au-lait spot (HP:0000957)2.16033573
79Gaze-evoked nystagmus (HP:0000640)2.15976812
80Pendular nystagmus (HP:0012043)2.14129013
81Irregular epiphyses (HP:0010582)2.13591745
82Arteriovenous malformation (HP:0100026)2.13489593
83Aplasia involving forearm bones (HP:0009822)2.12928838
84Absent forearm bone (HP:0003953)2.12928838
85Oligodactyly (HP:0012165)2.09660515
86Sloping forehead (HP:0000340)2.07726734
87Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.07443167
88Short 1st metacarpal (HP:0010034)2.07443167
89Microtia (HP:0008551)2.06544358
90Abnormality of the astrocytes (HP:0100707)2.05841448
91Astrocytoma (HP:0009592)2.05841448
92Aplasia/Hypoplasia of the fovea (HP:0008060)2.04634212
93Hypoplasia of the fovea (HP:0007750)2.04634212
94Synostosis of carpal bones (HP:0005048)2.03952507
95Progressive external ophthalmoplegia (HP:0000590)2.03312980
96Squamous cell carcinoma (HP:0002860)2.02406188
97Tracheoesophageal fistula (HP:0002575)2.01841507
98Abnormality of the pons (HP:0007361)1.99078194
99Embryonal neoplasm (HP:0002898)1.97410569
100Aplasia/Hypoplasia of the breasts (HP:0010311)1.96481604
101Triphalangeal thumb (HP:0001199)1.96337183
102Flat capital femoral epiphysis (HP:0003370)1.95724022
103Megaloblastic anemia (HP:0001889)1.95209997
104Glioma (HP:0009733)1.95041376
105Natal tooth (HP:0000695)1.94980677
106Neoplasm of the adrenal cortex (HP:0100641)1.93722819
107Hand muscle atrophy (HP:0009130)1.93643542
108Albinism (HP:0001022)1.93306260
109Rhabdomyosarcoma (HP:0002859)1.92703445
110Pelvic girdle muscle weakness (HP:0003749)1.91906968
111Lymphoma (HP:0002665)1.91505698
112Small epiphyses (HP:0010585)1.90414961
113Biliary tract neoplasm (HP:0100574)1.90017126
114Volvulus (HP:0002580)1.89978077
115Neoplasm of the oral cavity (HP:0100649)1.89219835
116Degeneration of anterior horn cells (HP:0002398)1.89068245
117Abnormality of the anterior horn cell (HP:0006802)1.89068245
118Neoplasm of the pancreas (HP:0002894)1.88904295
119Abnormal umbilical cord blood vessels (HP:0011403)1.88758187
120Single umbilical artery (HP:0001195)1.88758187
121Abnormality of the fetal cardiovascular system (HP:0010948)1.88758187
122Secondary amenorrhea (HP:0000869)1.88539600
123Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.87454997
124IgM deficiency (HP:0002850)1.87206895
125Microglossia (HP:0000171)1.87195631
126Abnormality of the prostate (HP:0008775)1.83754877
127Pancytopenia (HP:0001876)1.83345589
128Fibular hypoplasia (HP:0003038)1.83027503
129Severe visual impairment (HP:0001141)1.82332612
130Cellular immunodeficiency (HP:0005374)1.78552486
131Abnormality of the corticospinal tract (HP:0002492)1.78369700
132Abnormality of glycolysis (HP:0004366)1.78156222
133Abnormality of the lumbar spine (HP:0100712)1.77561510
134IgG deficiency (HP:0004315)1.77130465
135Abnormality of methionine metabolism (HP:0010901)1.76154952
136Microretrognathia (HP:0000308)1.76108014
137Type I transferrin isoform profile (HP:0003642)1.75804470
138Selective tooth agenesis (HP:0001592)1.75476565
139Aplasia/Hypoplasia of the sternum (HP:0006714)1.75194698
140Slender long bone (HP:0003100)1.74827760
141Increased serum lactate (HP:0002151)1.74745475
142Premature ovarian failure (HP:0008209)1.73670869
143Gonadotropin excess (HP:0000837)1.72985378
144Fair hair (HP:0002286)1.72781604
145Amaurosis fugax (HP:0100576)1.72660675
146Premature graying of hair (HP:0002216)1.72559467
147Sparse lateral eyebrow (HP:0005338)1.72135154
148Abnormality of vitamin B metabolism (HP:0004340)1.71757686
149Type II lissencephaly (HP:0007260)1.71735207
150Abnormality of the 1st metacarpal (HP:0010009)1.71634696
151Stillbirth (HP:0003826)1.70901146
152Anal atresia (HP:0002023)1.68526452
153Shoulder girdle muscle weakness (HP:0003547)1.67793956
154Advanced eruption of teeth (HP:0006288)1.67467708
155Basal cell carcinoma (HP:0002671)1.67455050
156Type 2 muscle fiber atrophy (HP:0003554)1.67321147
157Back pain (HP:0003418)1.66260762
158Ankle contracture (HP:0006466)1.65176821
159Methylmalonic acidemia (HP:0002912)1.64874899
160Acute necrotizing encephalopathy (HP:0006965)1.63808404
161Abnormality of the labia (HP:0000058)1.63603087
162Upper motor neuron abnormality (HP:0002127)1.61554447
163Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.58501823
164Unilateral renal agenesis (HP:0000122)1.56832461

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.99591221
2BRSK23.88794905
3WEE13.81887191
4ACVR1B3.44372977
5PNCK3.37828542
6EIF2AK13.36121570
7BUB13.22293211
8NEK23.03316382
9PDK22.87272263
10SRPK12.87168267
11TRIM282.59831475
12EIF2AK32.27201474
13MKNK22.25760312
14TTK2.20108305
15PLK42.19680481
16BMPR1B2.18416543
17PLK12.15028504
18IRAK32.08986251
19PLK32.07795896
20MKNK12.06884457
21BRSK12.02017016
22MAP3K121.89993412
23RPS6KA41.78279441
24DYRK31.77347434
25AURKB1.67849339
26MARK31.64280853
27STK38L1.62827768
28CCNB11.62410822
29CDK121.61870986
30CHEK21.61711606
31MAP3K41.60135817
32STK31.55770916
33TAF11.51028764
34FRK1.50385440
35ATR1.48010722
36CDK71.45178536
37CDK191.40391833
38CHEK11.38312913
39NME11.36049770
40PIM11.35413994
41LATS21.32147264
42NEK11.29603309
43LATS11.27344151
44MET1.19933945
45AKT21.13829381
46SCYL21.13340409
47VRK11.12972268
48STK241.12760619
49STK101.12324864
50AKT31.09055970
51CDK41.06793304
52STK41.05298873
53MST1R1.03657477
54NME21.01265558
55LIMK11.00553190
56TEC1.00148048
57MELK0.99738152
58VRK20.99177551
59ATM0.96802334
60MUSK0.96400168
61MAP3K80.93364790
62STK390.92363830
63ZAK0.92247414
64BCR0.90835426
65TSSK60.89167111
66CAMK1G0.86888832
67MAP4K10.86177748
68CDK20.84517632
69TIE10.81537480
70AURKA0.79561778
71JAK30.76099450
72MST40.76000095
73EIF2AK20.75428719
74ERBB40.74021421
75CSNK1G30.73916600
76CSNK1A1L0.73548020
77CHUK0.73332243
78CSNK1G10.73051891
79PRKCI0.71455577
80IRAK40.68061152
81FGFR10.67591263
82CDK10.67465259
83PINK10.66899787
84BRD40.64293716
85CSNK1E0.62240370
86BRAF0.60089876
87CDK60.59132066
88TXK0.57764513
89PIM20.57136225
90CSNK2A10.56206077
91MAP3K140.54829014
92CDK30.53333228
93OXSR10.53049383
94BMPR20.52998208
95ADRBK20.52228810
96TRPM70.51794216
97STK160.51766098
98MAP3K60.51680543
99ALK0.51347229
100RPS6KB20.50528645
101TGFBR10.49834119
102RAF10.48773372
103PBK0.48464554
104BTK0.47606692
105PAK40.47482426
106PRKDC0.46520659
107DYRK20.46119979
108EPHA20.45903504
109MAPKAPK50.44079632
110PTK2B0.43803380
111CSNK1G20.43593239
112MAP3K20.41716168
113KSR10.41642926
114WNK40.40881341
115SIK30.40727578
116GRK10.40495198
117TYK20.39562768
118CDK90.39426791
119ERBB30.38980690
120CSNK2A20.37790065
121IKBKB0.35885515
122TNK20.34865319
123ABL20.34390081
124PAK10.34299159
125MAP3K50.33961008
126MAP3K30.33300083
127PASK0.32280927
128NEK60.30300953
129NUAK10.27851073
130AKT10.27610431
131CDK80.27046887
132FGFR30.26781629
133NEK90.26525527
134LYN0.24784636
135ITK0.24581170

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.33213890
2RNA polymerase_Homo sapiens_hsa030203.78847874
3DNA replication_Homo sapiens_hsa030303.70407837
4Mismatch repair_Homo sapiens_hsa034303.49609060
5RNA transport_Homo sapiens_hsa030133.38654486
6Cell cycle_Homo sapiens_hsa041103.31975261
7Protein export_Homo sapiens_hsa030603.26271767
8Homologous recombination_Homo sapiens_hsa034403.00905601
9Fanconi anemia pathway_Homo sapiens_hsa034602.83181902
10Spliceosome_Homo sapiens_hsa030402.82801580
11Basal transcription factors_Homo sapiens_hsa030222.64633645
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.52678887
13Vitamin B6 metabolism_Homo sapiens_hsa007502.26673853
14Base excision repair_Homo sapiens_hsa034102.25703357
15RNA degradation_Homo sapiens_hsa030182.24219034
16Nucleotide excision repair_Homo sapiens_hsa034202.22718780
17Proteasome_Homo sapiens_hsa030502.21507669
18Pyrimidine metabolism_Homo sapiens_hsa002402.20389143
19p53 signaling pathway_Homo sapiens_hsa041152.06770386
20mRNA surveillance pathway_Homo sapiens_hsa030151.94351899
21One carbon pool by folate_Homo sapiens_hsa006701.85382024
22Non-homologous end-joining_Homo sapiens_hsa034501.83626468
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.81900879
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.56438802
25Herpes simplex infection_Homo sapiens_hsa051681.41362643
26Propanoate metabolism_Homo sapiens_hsa006401.39568261
27Selenocompound metabolism_Homo sapiens_hsa004501.38302037
28Purine metabolism_Homo sapiens_hsa002301.37183090
29Epstein-Barr virus infection_Homo sapiens_hsa051691.36890139
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34859978
31Oocyte meiosis_Homo sapiens_hsa041141.31621819
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.24852939
33Pyruvate metabolism_Homo sapiens_hsa006201.23460072
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23123109
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.21082469
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.17675866
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.16795659
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.13380410
39Fatty acid elongation_Homo sapiens_hsa000621.10957159
40Pentose phosphate pathway_Homo sapiens_hsa000301.07249413
41Ribosome_Homo sapiens_hsa030101.05213053
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01068313
43MicroRNAs in cancer_Homo sapiens_hsa052060.99634291
44Sulfur metabolism_Homo sapiens_hsa009200.97205181
45Antigen processing and presentation_Homo sapiens_hsa046120.94164106
46Viral carcinogenesis_Homo sapiens_hsa052030.93894715
47beta-Alanine metabolism_Homo sapiens_hsa004100.93731512
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93189936
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92430658
50Influenza A_Homo sapiens_hsa051640.89407971
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88066685
52Primary immunodeficiency_Homo sapiens_hsa053400.87730692
53N-Glycan biosynthesis_Homo sapiens_hsa005100.87676498
54HTLV-I infection_Homo sapiens_hsa051660.87056222
55Measles_Homo sapiens_hsa051620.86756973
56TGF-beta signaling pathway_Homo sapiens_hsa043500.86210630
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85184718
58Sulfur relay system_Homo sapiens_hsa041220.82668155
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81405455
60Caffeine metabolism_Homo sapiens_hsa002320.81222054
61Oxidative phosphorylation_Homo sapiens_hsa001900.80709291
62Collecting duct acid secretion_Homo sapiens_hsa049660.80684199
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.80375293
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80334931
65Sphingolipid metabolism_Homo sapiens_hsa006000.79544494
66Vibrio cholerae infection_Homo sapiens_hsa051100.78411942
67Lysine degradation_Homo sapiens_hsa003100.77735233
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73252232
69Thyroid cancer_Homo sapiens_hsa052160.70595803
70Folate biosynthesis_Homo sapiens_hsa007900.70149610
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69823722
72Small cell lung cancer_Homo sapiens_hsa052220.69356159
73Arginine and proline metabolism_Homo sapiens_hsa003300.69061627
74Legionellosis_Homo sapiens_hsa051340.67321097
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.66182319
76Hepatitis B_Homo sapiens_hsa051610.65564136
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65433746
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65425106
79Parkinsons disease_Homo sapiens_hsa050120.62610348
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61821283
81Carbon metabolism_Homo sapiens_hsa012000.60740146
82Graft-versus-host disease_Homo sapiens_hsa053320.59006200
83Glutathione metabolism_Homo sapiens_hsa004800.58454677
84Apoptosis_Homo sapiens_hsa042100.57684676
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56348890
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56147689
87Metabolic pathways_Homo sapiens_hsa011000.56108282
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56054739
89Huntingtons disease_Homo sapiens_hsa050160.55711870
90Leishmaniasis_Homo sapiens_hsa051400.55449395
91Colorectal cancer_Homo sapiens_hsa052100.55392862
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55339448
93Regulation of autophagy_Homo sapiens_hsa041400.53492092
94FoxO signaling pathway_Homo sapiens_hsa040680.52846072
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52701663
96Allograft rejection_Homo sapiens_hsa053300.52564527
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52479842
98Fatty acid metabolism_Homo sapiens_hsa012120.52391319
99Autoimmune thyroid disease_Homo sapiens_hsa053200.50002952
100Other glycan degradation_Homo sapiens_hsa005110.48923262
101Shigellosis_Homo sapiens_hsa051310.48557021
102Hematopoietic cell lineage_Homo sapiens_hsa046400.47379370
103Dorso-ventral axis formation_Homo sapiens_hsa043200.47006491
104Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43574175
105Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42364365
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.42262817
107Pancreatic cancer_Homo sapiens_hsa052120.41648395
108Fatty acid degradation_Homo sapiens_hsa000710.40836333
109TNF signaling pathway_Homo sapiens_hsa046680.40389317
110Adherens junction_Homo sapiens_hsa045200.39350444
111Biosynthesis of amino acids_Homo sapiens_hsa012300.39201455
112Systemic lupus erythematosus_Homo sapiens_hsa053220.39097206
113Viral myocarditis_Homo sapiens_hsa054160.36775864
114Cysteine and methionine metabolism_Homo sapiens_hsa002700.36530883
115Vitamin digestion and absorption_Homo sapiens_hsa049770.36286181
116Circadian rhythm_Homo sapiens_hsa047100.35168159
117Butanoate metabolism_Homo sapiens_hsa006500.34272230
118Prostate cancer_Homo sapiens_hsa052150.33357961
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33310019
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32813912
121Fat digestion and absorption_Homo sapiens_hsa049750.31862415
122B cell receptor signaling pathway_Homo sapiens_hsa046620.31224019
123Malaria_Homo sapiens_hsa051440.31149696
124Phototransduction_Homo sapiens_hsa047440.30777118
125Tuberculosis_Homo sapiens_hsa051520.30748347
126Toll-like receptor signaling pathway_Homo sapiens_hsa046200.30377576
127Type I diabetes mellitus_Homo sapiens_hsa049400.30047790
128Peroxisome_Homo sapiens_hsa041460.30033111
129Pathways in cancer_Homo sapiens_hsa052000.29008414
130Galactose metabolism_Homo sapiens_hsa000520.28765923
131Melanoma_Homo sapiens_hsa052180.27913652
132Hippo signaling pathway_Homo sapiens_hsa043900.27623192
133Tryptophan metabolism_Homo sapiens_hsa003800.26535662
134T cell receptor signaling pathway_Homo sapiens_hsa046600.25532614
135Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25274800
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.25054028
137Arginine biosynthesis_Homo sapiens_hsa002200.24391687
138Leukocyte transendothelial migration_Homo sapiens_hsa046700.24274144
139HIF-1 signaling pathway_Homo sapiens_hsa040660.24258946
140Renal cell carcinoma_Homo sapiens_hsa052110.24028442
141Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.22976588
142Toxoplasmosis_Homo sapiens_hsa051450.22898962
143Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.22034773
144Maturity onset diabetes of the young_Homo sapiens_hsa049500.21494118
145Chronic myeloid leukemia_Homo sapiens_hsa052200.21381440
146Asthma_Homo sapiens_hsa053100.21229109
147Acute myeloid leukemia_Homo sapiens_hsa052210.20828479
148Steroid biosynthesis_Homo sapiens_hsa001000.20374077
149Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.20177508
150Primary bile acid biosynthesis_Homo sapiens_hsa001200.19713228
151Endometrial cancer_Homo sapiens_hsa052130.19413505
152Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18477821
153Retinol metabolism_Homo sapiens_hsa008300.18417990
154Hepatitis C_Homo sapiens_hsa051600.16991466
155SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16771219
156Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.16288375
157Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15874483
158mTOR signaling pathway_Homo sapiens_hsa041500.14068971
159Salmonella infection_Homo sapiens_hsa051320.13406634
160Ether lipid metabolism_Homo sapiens_hsa005650.10163821

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