ZACN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: LGICZ1 is a zinc-activated ligand-gated ion channel that defines a new subgroup of the cysteine-loop superfamily of ligand-gated ion channels (Davies et al., 2003 [PubMed 12381728]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)7.28179507
2synaptic vesicle exocytosis (GO:0016079)5.83834089
3synaptic vesicle maturation (GO:0016188)5.38044240
4glutamate secretion (GO:0014047)5.29920280
5regulation of synapse structural plasticity (GO:0051823)5.01945762
6regulation of female receptivity (GO:0045924)4.96886605
7positive regulation of synapse maturation (GO:0090129)4.91689139
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.76879173
9neurotransmitter secretion (GO:0007269)4.63636769
10regulation of short-term neuronal synaptic plasticity (GO:0048172)4.55315785
11cell migration in hindbrain (GO:0021535)4.48018079
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.43269200
13positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.36650035
14female mating behavior (GO:0060180)4.29890873
15regulation of synaptic vesicle exocytosis (GO:2000300)4.13498737
16dendritic spine morphogenesis (GO:0060997)4.10239167
17regulation of synapse maturation (GO:0090128)4.04652580
18regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.99589750
19membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.99397275
20postsynaptic membrane organization (GO:0001941)3.86950403
21vocalization behavior (GO:0071625)3.86490012
22central nervous system myelination (GO:0022010)3.69461670
23axon ensheathment in central nervous system (GO:0032291)3.69461670
24locomotory exploration behavior (GO:0035641)3.66930627
25ionotropic glutamate receptor signaling pathway (GO:0035235)3.66402775
26regulation of synaptic vesicle transport (GO:1902803)3.66383230
27regulation of neuronal synaptic plasticity (GO:0048168)3.66303613
28GDP-mannose metabolic process (GO:0019673)3.64956843
29regulation of neurotransmitter levels (GO:0001505)3.58210682
30cerebellar granule cell differentiation (GO:0021707)3.53965142
31neuronal ion channel clustering (GO:0045161)3.53550689
32neurotransmitter transport (GO:0006836)3.50687212
33protein localization to synapse (GO:0035418)3.48964655
34positive regulation of membrane potential (GO:0045838)3.47919769
35neurotransmitter-gated ion channel clustering (GO:0072578)3.46504176
36auditory behavior (GO:0031223)3.43081360
37exploration behavior (GO:0035640)3.42971920
38dendritic spine organization (GO:0097061)3.38876002
39positive regulation of neurotransmitter transport (GO:0051590)3.38089518
40cellular potassium ion homeostasis (GO:0030007)3.36680767
41positive regulation of dendritic spine development (GO:0060999)3.36270188
42neuromuscular synaptic transmission (GO:0007274)3.30350555
43regulation of long-term neuronal synaptic plasticity (GO:0048169)3.30150484
44establishment of mitochondrion localization (GO:0051654)3.27933078
45synaptic transmission, glutamatergic (GO:0035249)3.27680294
46regulation of glutamate receptor signaling pathway (GO:1900449)3.25682148
47regulation of excitatory postsynaptic membrane potential (GO:0060079)3.22776021
48negative regulation of synaptic transmission, GABAergic (GO:0032229)3.22075953
49neuromuscular process controlling posture (GO:0050884)3.21332826
50cellular response to ATP (GO:0071318)3.16386051
51adenosine receptor signaling pathway (GO:0001973)3.14320839
52neuron cell-cell adhesion (GO:0007158)3.13791282
53positive regulation of neurotransmitter secretion (GO:0001956)3.10060065
54regulation of hydrogen peroxide metabolic process (GO:0010310)3.06638191
55synaptic vesicle endocytosis (GO:0048488)3.05542486
56regulation of ARF protein signal transduction (GO:0032012)3.02376021
57urinary tract smooth muscle contraction (GO:0014848)3.01730043
58regulation of postsynaptic membrane potential (GO:0060078)3.01538661
59establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.99885378
60mitochondrion transport along microtubule (GO:0047497)2.99885378
61cell-cell junction maintenance (GO:0045217)2.98457010
62regulation of synaptic plasticity (GO:0048167)2.96812113
63response to amphetamine (GO:0001975)2.95209653
64glutamate receptor signaling pathway (GO:0007215)2.94535216
65dopamine receptor signaling pathway (GO:0007212)2.93205960
66cochlea development (GO:0090102)2.93157771
67adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.91677893
68lung epithelium development (GO:0060428)2.91108651
69gamma-aminobutyric acid transport (GO:0015812)2.84420459
70membrane depolarization (GO:0051899)2.83282252
71neuromuscular process controlling balance (GO:0050885)2.82859160
72regulation of neurotransmitter secretion (GO:0046928)2.82286689
73response to auditory stimulus (GO:0010996)2.78248828
74semaphorin-plexin signaling pathway (GO:0071526)2.77590765
75regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.74251259
76regulation of dendritic spine morphogenesis (GO:0061001)2.73631107
77membrane depolarization during action potential (GO:0086010)2.72163917
78sodium ion export (GO:0071436)2.70201327
79regulation of respiratory gaseous exchange (GO:0043576)2.70161478
80regulation of voltage-gated calcium channel activity (GO:1901385)2.69807574
81peptidyl-tyrosine autophosphorylation (GO:0038083)2.68216244
82neuron-neuron synaptic transmission (GO:0007270)2.67072991
83regulation of neurotransmitter transport (GO:0051588)2.66389578
84regulation of respiratory system process (GO:0044065)2.65380929
85negative regulation of microtubule polymerization (GO:0031115)2.64655883
86L-amino acid import (GO:0043092)2.63835866
87negative regulation of axonogenesis (GO:0050771)2.63062262
88synaptic vesicle transport (GO:0048489)2.61440394
89establishment of synaptic vesicle localization (GO:0097480)2.61440394
90iron coordination entity transport (GO:1901678)2.60692496
91negative regulation of axon extension (GO:0030517)2.59368536
92learning (GO:0007612)2.58941416
93sensory perception of taste (GO:0050909)2.58345789
94potassium ion homeostasis (GO:0055075)2.58214078
95neuron recognition (GO:0008038)2.57981112
96regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.56972776
97detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.56393298
98detection of temperature stimulus involved in sensory perception (GO:0050961)2.56393298
99phosphatidylglycerol biosynthetic process (GO:0006655)2.55629128
100synaptic transmission (GO:0007268)2.55505045

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.96828684
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.16078446
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.07078795
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.06850639
5ERG_21242973_ChIP-ChIP_JURKAT_Human2.98082590
6CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.97507362
7EZH2_22144423_ChIP-Seq_EOC_Human2.89325136
8LXR_22292898_ChIP-Seq_THP-1_Human2.82381266
9MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.69310591
10DROSHA_22980978_ChIP-Seq_HELA_Human2.42719780
11CTCF_27219007_Chip-Seq_Bcells_Human2.42540852
12EZH2_27294783_Chip-Seq_ESCs_Mouse2.31941319
13P68_20966046_ChIP-Seq_HELA_Human2.30829366
14SUZ12_27294783_Chip-Seq_ESCs_Mouse2.27874797
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.22979134
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.09136995
17DNAJC2_21179169_ChIP-ChIP_NT2_Human2.08951126
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.00876042
19JARID2_20064375_ChIP-Seq_MESCs_Mouse1.99960807
20TET1_21451524_ChIP-Seq_MESCs_Mouse1.98939638
21KDM2B_26808549_Chip-Seq_K562_Human1.97479493
22KDM2B_26808549_Chip-Seq_SUP-B15_Human1.96851435
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.94602761
24REST_21632747_ChIP-Seq_MESCs_Mouse1.94264754
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.93868942
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.93211179
27EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.90701242
28SMC4_20622854_ChIP-Seq_HELA_Human1.90226418
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.87145314
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.86584414
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.86584414
32RACK7_27058665_Chip-Seq_MCF-7_Human1.83811539
33SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.82981796
34VDR_21846776_ChIP-Seq_THP-1_Human1.80553388
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.80188365
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.79822626
37SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.78921133
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.78244299
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.78058262
40SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.77554506
41ZFP281_18757296_ChIP-ChIP_E14_Mouse1.76915194
42SA1_27219007_Chip-Seq_ERYTHROID_Human1.75018963
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.74930750
44CREB1_26743006_Chip-Seq_LNCaP_Human1.73235828
45SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.70028125
46KDM2B_26808549_Chip-Seq_DND41_Human1.64798121
47SRY_22984422_ChIP-ChIP_TESTIS_Rat1.64086686
48* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.63603225
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.62592970
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.61880861
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61076581
52BCL6_27268052_Chip-Seq_Bcells_Human1.56887593
53* BCOR_27268052_Chip-Seq_Bcells_Human1.55142114
54CTCF_27219007_Chip-Seq_ERYTHROID_Human1.54598033
55SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.54494908
56RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.54317359
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47947583
58SA1_27219007_Chip-Seq_Bcells_Human1.46024419
59SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.45831380
60PHF8_20622854_ChIP-Seq_HELA_Human1.44309731
61ZFP281_27345836_Chip-Seq_ESCs_Mouse1.40432959
62SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.39939878
63CTCF_20526341_ChIP-Seq_ESCs_Human1.37691014
64UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.37679178
65E2F1_20622854_ChIP-Seq_HELA_Human1.36092488
66CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.34996227
67ELF1_20517297_ChIP-Seq_JURKAT_Human1.33796018
68TP53_20018659_ChIP-ChIP_R1E_Mouse1.33685691
69SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.33546302
70RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.33118607
71SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.32385128
72OCT4_19829295_ChIP-Seq_ESCs_Human1.30221453
73FOXP1_21924763_ChIP-Seq_HESCs_Human1.27805816
74SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26044367
75TET1_21490601_ChIP-Seq_MESCs_Mouse1.23727809
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22815294
77RARB_24833708_ChIP-Seq_LIVER_Mouse1.22339549
78TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.20981448
79RING1B_27294783_Chip-Seq_ESCs_Mouse1.20668105
80TP63_22573176_ChIP-Seq_HFKS_Human1.17355588
81ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17122347
82RARA_24833708_ChIP-Seq_LIVER_Mouse1.17114759
83GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17080122
84OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.13583791
85EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.12353659
86CTCF_26484167_Chip-Seq_Bcells_Mouse1.11597038
87NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.09206091
88ELK3_25401928_ChIP-Seq_HUVEC_Human1.06972082
89YY1_22570637_ChIP-Seq_MALME-3M_Human1.06823150
90PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06415617
91CTCF_21964334_ChIP-Seq_BJAB-B_Human1.05844909
92TCF7_22412390_ChIP-Seq_EML_Mouse1.04820939
93SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.03946236
94BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.03341506
95CTCF_18555785_ChIP-Seq_MESCs_Mouse1.02887881
96KDM2B_26808549_Chip-Seq_JURKAT_Human1.02754335
97WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02145978
98ERA_21632823_ChIP-Seq_H3396_Human1.01940242
99E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01041383
100STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.00944101

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.90227900
2MP0005423_abnormal_somatic_nervous4.31486300
3MP0003880_abnormal_central_pattern4.14554528
4MP0001968_abnormal_touch/_nociception3.37223815
5MP0003635_abnormal_synaptic_transmissio3.26330662
6MP0002064_seizures2.82295343
7MP0004270_analgesia2.73707409
8MP0009745_abnormal_behavioral_response2.71417865
9MP0002822_catalepsy2.69623211
10MP0002063_abnormal_learning/memory/cond2.66977734
11MP0002736_abnormal_nociception_after2.61728339
12MP0002735_abnormal_chemical_nociception2.53587171
13MP0002734_abnormal_mechanical_nocicepti2.40729527
14MP0002272_abnormal_nervous_system2.30646970
15MP0001188_hyperpigmentation2.30576424
16MP0001486_abnormal_startle_reflex2.26835208
17MP0009379_abnormal_foot_pigmentation2.17202171
18MP0002572_abnormal_emotion/affect_behav2.16810470
19MP0003879_abnormal_hair_cell2.13089263
20MP0001970_abnormal_pain_threshold2.06539809
21MP0002653_abnormal_ependyma_morphology1.94142227
22MP0005646_abnormal_pituitary_gland1.85814745
23MP0002733_abnormal_thermal_nociception1.82866898
24MP0001986_abnormal_taste_sensitivity1.82763323
25MP0009046_muscle_twitch1.79284368
26MP0002249_abnormal_larynx_morphology1.65106325
27MP0001905_abnormal_dopamine_level1.63140173
28MP0001502_abnormal_circadian_rhythm1.62571075
29MP0003123_paternal_imprinting1.61441327
30MP0003787_abnormal_imprinting1.61346633
31MP0003136_yellow_coat_color1.60741976
32MP0000778_abnormal_nervous_system1.57075891
33MP0004885_abnormal_endolymph1.55618509
34MP0008569_lethality_at_weaning1.48720904
35MP0002557_abnormal_social/conspecific_i1.47886515
36MP0004742_abnormal_vestibular_system1.43612715
37MP0002067_abnormal_sensory_capabilities1.43225140
38MP0004133_heterotaxia1.38240132
39MP0000955_abnormal_spinal_cord1.36407989
40MP0006276_abnormal_autonomic_nervous1.35471388
41MP0008872_abnormal_physiological_respon1.31930820
42MP0001501_abnormal_sleep_pattern1.31389823
43MP0005386_behavior/neurological_phenoty1.30957118
44MP0004924_abnormal_behavior1.30957118
45MP0002882_abnormal_neuron_morphology1.30086283
46MP0002184_abnormal_innervation1.28146762
47MP0003938_abnormal_ear_development1.27516755
48MP0008875_abnormal_xenobiotic_pharmacok1.26906209
49MP0004811_abnormal_neuron_physiology1.24529941
50MP0002066_abnormal_motor_capabilities/c1.24396416
51MP0000026_abnormal_inner_ear1.23634582
52MP0000678_abnormal_parathyroid_gland1.16295355
53MP0001485_abnormal_pinna_reflex1.13285436
54MP0001440_abnormal_grooming_behavior1.09517853
55MP0005174_abnormal_tail_pigmentation1.07609127
56MP0002638_abnormal_pupillary_reflex1.07324529
57MP0005551_abnormal_eye_electrophysiolog1.03123031
58MP0003172_abnormal_lysosome_physiology1.02741139
59MP0008995_early_reproductive_senescence1.02702578
60MP0005409_darkened_coat_color1.02032267
61MP0004043_abnormal_pH_regulation0.99379073
62MP0002909_abnormal_adrenal_gland0.99350084
63MP0001963_abnormal_hearing_physiology0.98035512
64MP0002152_abnormal_brain_morphology0.97636047
65MP0005394_taste/olfaction_phenotype0.93417333
66MP0005499_abnormal_olfactory_system0.93417333
67MP0002752_abnormal_somatic_nervous0.93224046
68MP0003183_abnormal_peptide_metabolism0.91458121
69MP0003633_abnormal_nervous_system0.91230239
70MP0009780_abnormal_chondrocyte_physiolo0.90129603
71MP0002229_neurodegeneration0.89380761
72MP0003634_abnormal_glial_cell0.88553403
73MP0000631_abnormal_neuroendocrine_gland0.88314071
74MP0005083_abnormal_biliary_tract0.87988174
75MP0001765_abnormal_ion_homeostasis0.84521364
76MP0008874_decreased_physiological_sensi0.83908435
77MP0003137_abnormal_impulse_conducting0.82113494
78MP0005167_abnormal_blood-brain_barrier0.81781654
79MP0002069_abnormal_eating/drinking_beha0.81405249
80MP0005171_absent_coat_pigmentation0.80181573
81MP0003631_nervous_system_phenotype0.78776577
82MP0001529_abnormal_vocalization0.78125794
83MP0005377_hearing/vestibular/ear_phenot0.77342534
84MP0003878_abnormal_ear_physiology0.77342534
85MP0006292_abnormal_olfactory_placode0.74355733
86MP0004019_abnormal_vitamin_homeostasis0.73883488
87MP0001756_abnormal_urination0.73744246
88MP0000920_abnormal_myelination0.71494449
89MP0005535_abnormal_body_temperature0.70756381
90MP0008789_abnormal_olfactory_epithelium0.69875211
91MP0002089_abnormal_postnatal_growth/wei0.69685890
92MP0000538_abnormal_urinary_bladder0.67847701
93MP0000566_synostosis0.66007522
94MP0001664_abnormal_digestion0.64891356
95MP0003119_abnormal_digestive_system0.64859834
96MP0003283_abnormal_digestive_organ0.63000323
97MP0001984_abnormal_olfaction0.62548979
98MP0003690_abnormal_glial_cell0.62523582
99MP0003329_amyloid_beta_deposits0.62282067
100MP0004142_abnormal_muscle_tone0.61699421

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.01903363
2Annular pancreas (HP:0001734)4.09826533
3Focal motor seizures (HP:0011153)3.87955812
4Ankle clonus (HP:0011448)3.66347858
5Visual hallucinations (HP:0002367)3.60363214
6Epileptic encephalopathy (HP:0200134)3.57502310
7Focal seizures (HP:0007359)3.54228721
8Obstructive sleep apnea (HP:0002870)3.47642985
9Akinesia (HP:0002304)3.36915646
10Supranuclear gaze palsy (HP:0000605)3.08739884
11Rib fusion (HP:0000902)3.06592287
12Testicular atrophy (HP:0000029)3.06477594
13Status epilepticus (HP:0002133)3.00677526
14Progressive cerebellar ataxia (HP:0002073)2.93032571
15Anomalous pulmonary venous return (HP:0010772)2.91559947
16Decreased circulating renin level (HP:0003351)2.89781884
17Abnormal respiratory motile cilium morphology (HP:0005938)2.87699656
18Abnormal respiratory epithelium morphology (HP:0012253)2.87699656
19Action tremor (HP:0002345)2.83301334
20Urinary bladder sphincter dysfunction (HP:0002839)2.83163883
21Febrile seizures (HP:0002373)2.72290681
22Male infertility (HP:0003251)2.61702957
23Abnormality of the pulmonary veins (HP:0011718)2.56963797
24Cerebral hypomyelination (HP:0006808)2.55612135
25Spastic gait (HP:0002064)2.49852017
26Turricephaly (HP:0000262)2.48227982
27Abnormality of binocular vision (HP:0011514)2.45046551
28Diplopia (HP:0000651)2.45046551
29Sleep apnea (HP:0010535)2.44868094
30Impaired smooth pursuit (HP:0007772)2.40096173
31Limb dystonia (HP:0002451)2.35263666
32Nuclear cataract (HP:0100018)2.34721586
33Generalized tonic-clonic seizures (HP:0002069)2.32805271
34Stridor (HP:0010307)2.31136865
35Hyperthyroidism (HP:0000836)2.30518071
36Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.30094143
37Prolonged QT interval (HP:0001657)2.29932662
38Absence seizures (HP:0002121)2.27576086
39Abnormal eating behavior (HP:0100738)2.25669326
40Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.22075340
41Thin bony cortex (HP:0002753)2.20083704
42Absent speech (HP:0001344)2.17428456
43Abnormal ciliary motility (HP:0012262)2.17186386
44Dynein arm defect of respiratory motile cilia (HP:0012255)2.16995474
45Absent/shortened dynein arms (HP:0200106)2.16995474
46Hyperglycinuria (HP:0003108)2.16577347
47Abnormal respiratory motile cilium physiology (HP:0012261)2.13518086
48Truncal ataxia (HP:0002078)2.12918184
49Dialeptic seizures (HP:0011146)2.11712088
50Congenital stationary night blindness (HP:0007642)2.10275707
51Stereotypic behavior (HP:0000733)2.08592635
52Neuronal loss in central nervous system (HP:0002529)2.08102773
53Genetic anticipation (HP:0003743)2.07005673
54Focal dystonia (HP:0004373)2.04317112
55Amblyopia (HP:0000646)2.03677795
56Myopathic facies (HP:0002058)2.03453874
57Atelectasis (HP:0100750)2.01984311
58Progressive microcephaly (HP:0000253)2.01729674
59Torticollis (HP:0000473)2.00991802
60Mutism (HP:0002300)1.99723341
61Neurofibrillary tangles (HP:0002185)1.97945758
62Polyphagia (HP:0002591)1.96254339
63Impaired vibration sensation in the lower limbs (HP:0002166)1.93923447
64Papilledema (HP:0001085)1.92875280
65Delusions (HP:0000746)1.92734972
66Abnormality of renin-angiotensin system (HP:0000847)1.88790940
67Craniofacial dystonia (HP:0012179)1.86626588
68Atonic seizures (HP:0010819)1.86044088
69Spinal canal stenosis (HP:0003416)1.85509639
70Bulbar palsy (HP:0001283)1.84511532
71Polydipsia (HP:0001959)1.84030002
72Abnormal drinking behavior (HP:0030082)1.84030002
73Broad-based gait (HP:0002136)1.83361584
74Depression (HP:0000716)1.82235819
75Clumsiness (HP:0002312)1.82198671
76Urinary urgency (HP:0000012)1.82047128
77Clonus (HP:0002169)1.81621491
78Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.81427218
79Anxiety (HP:0000739)1.81319151
80Mesangial abnormality (HP:0001966)1.81155633
81Diaphragmatic weakness (HP:0009113)1.77053772
82Poor eye contact (HP:0000817)1.75030600
83Poor suck (HP:0002033)1.74541148
84Infertility (HP:0000789)1.74036593
85Hypoplastic left heart (HP:0004383)1.72931658
86Abnormal EKG (HP:0003115)1.72852362
87External ophthalmoplegia (HP:0000544)1.72741408
88Abnormal number of erythroid precursors (HP:0012131)1.72017779
89Hypoplastic heart (HP:0001961)1.71386551
90Abnormality of the periventricular white matter (HP:0002518)1.69430856
91Abnormality of ocular smooth pursuit (HP:0000617)1.68848195
92Fetal akinesia sequence (HP:0001989)1.68611021
93Nasal polyposis (HP:0100582)1.67251831
94Hemiparesis (HP:0001269)1.64695365
95Neonatal onset (HP:0003623)1.64389962
96Intellectual disability, severe (HP:0010864)1.63531849
97Inability to walk (HP:0002540)1.63309084
98Postural instability (HP:0002172)1.62636640
99Bronchomalacia (HP:0002780)1.61174602
100Delayed CNS myelination (HP:0002188)1.60768674

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.72758979
2MAPK153.40274628
3EPHA43.07123834
4MARK13.05306607
5DAPK22.98222478
6TRIB32.93127746
7SIK22.84234255
8PRKD32.74085949
9CAMKK12.40388112
10NTRK22.36796345
11SIK12.13733134
12PAK62.06553972
13UHMK11.95981600
14NME21.84241186
15TNK21.77127013
16CASK1.71578913
17MAP3K111.61518408
18MAP2K61.51849735
19NME11.46106236
20MARK21.43507682
21TYRO31.39726978
22MINK11.39336037
23PRKCI1.35708390
24TESK11.34420338
25DAPK11.33332803
26CDK51.26641059
27MATK1.22913719
28CDK151.20650474
29CAMK11.16800796
30CDK11A1.16581999
31RIPK11.15804340
32SGK4941.13135622
33SGK2231.13135622
34MAPK131.12480337
35CDK181.11046685
36GRK51.07373487
37DYRK21.06034436
38WNK41.05889918
39VRK21.04785919
40PRKCH1.04012855
41ERBB20.99802847
42SMG10.97967670
43PINK10.94712550
44CDK140.93524071
45PRKCG0.93073871
46MST1R0.90800988
47PKN20.90082953
48RPS6KA20.86013928
49CAMK2B0.83634152
50STK110.80108047
51PHKG20.78427397
52PHKG10.78427397
53ERN10.75232414
54TAOK10.75029889
55SGK10.73992079
56MAP2K40.72174056
57ALK0.67717350
58PRKD20.67335237
59MAP2K20.64496185
60PKN10.64254015
61MAPK80.62937866
62MAPK120.61993368
63EPHA20.59407565
64TLK10.58862390
65CAMK2G0.58513542
66GRK60.57115789
67DYRK1A0.56366647
68CAMK2A0.55892938
69CDC42BPA0.54678850
70INSRR0.54500313
71DAPK30.54240519
72RPS6KC10.54174541
73RPS6KL10.54174541
74RPS6KA60.53870933
75PTK60.53821979
76STK380.52416041
77GRK10.51634194
78IRAK20.51482005
79ADRBK20.51159015
80RIPK40.50773986
81PRKCZ0.50692643
82SGK20.50379664
83DYRK1B0.49210295
84EPHB20.49102100
85BRSK10.48943645
86ICK0.48904214
87CSNK1A10.47553785
88TESK20.47442344
89CAMK1D0.46430290
90MAP2K70.45629355
91MAPK100.45414494
92ADRBK10.44487727
93FGFR40.44289663
94LRRK20.44253446
95NEK60.43044499
96RPS6KA30.42044883
97PAK30.41219525
98PRKACA0.41102678
99HIPK20.40102648
100BMX0.40023091

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.89309587
2Synaptic vesicle cycle_Homo sapiens_hsa047213.65789092
3Sulfur relay system_Homo sapiens_hsa041222.90365881
4Cocaine addiction_Homo sapiens_hsa050302.75464745
5Amphetamine addiction_Homo sapiens_hsa050312.63379640
6Morphine addiction_Homo sapiens_hsa050322.39010800
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.37213227
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.36644357
9Circadian entrainment_Homo sapiens_hsa047132.23900517
10Glutamatergic synapse_Homo sapiens_hsa047242.23340130
11GABAergic synapse_Homo sapiens_hsa047272.19624710
12Insulin secretion_Homo sapiens_hsa049112.18613264
13Dopaminergic synapse_Homo sapiens_hsa047282.13523546
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.00344689
15Collecting duct acid secretion_Homo sapiens_hsa049661.84811154
16Taste transduction_Homo sapiens_hsa047421.79634600
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74056378
18Cholinergic synapse_Homo sapiens_hsa047251.73352711
19Gastric acid secretion_Homo sapiens_hsa049711.60839480
20Long-term potentiation_Homo sapiens_hsa047201.59162772
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.58573852
22Oxidative phosphorylation_Homo sapiens_hsa001901.44947639
23Notch signaling pathway_Homo sapiens_hsa043301.39503620
24Salivary secretion_Homo sapiens_hsa049701.30359929
25Calcium signaling pathway_Homo sapiens_hsa040201.30139686
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.29319339
27Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.28107515
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26570669
29cAMP signaling pathway_Homo sapiens_hsa040241.26413547
30Cardiac muscle contraction_Homo sapiens_hsa042601.25031026
31Histidine metabolism_Homo sapiens_hsa003401.21291354
32Axon guidance_Homo sapiens_hsa043601.20544496
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.18125137
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.18097307
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17916440
36Phenylalanine metabolism_Homo sapiens_hsa003601.16573888
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13481972
38Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.10635643
39Serotonergic synapse_Homo sapiens_hsa047261.07692283
40Oxytocin signaling pathway_Homo sapiens_hsa049211.06907860
41ABC transporters_Homo sapiens_hsa020101.04974181
42Melanogenesis_Homo sapiens_hsa049161.04705582
43Estrogen signaling pathway_Homo sapiens_hsa049151.03586250
44GnRH signaling pathway_Homo sapiens_hsa049121.01694688
45Renin secretion_Homo sapiens_hsa049241.00218294
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00034551
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97144011
48Alzheimers disease_Homo sapiens_hsa050100.95055202
49Parkinsons disease_Homo sapiens_hsa050120.93571121
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91494083
51Other glycan degradation_Homo sapiens_hsa005110.90574327
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89002144
53VEGF signaling pathway_Homo sapiens_hsa043700.86605285
54Vibrio cholerae infection_Homo sapiens_hsa051100.86587547
55Phototransduction_Homo sapiens_hsa047440.86429168
56Huntingtons disease_Homo sapiens_hsa050160.85652365
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.80222545
58Fructose and mannose metabolism_Homo sapiens_hsa000510.76610438
59Arginine and proline metabolism_Homo sapiens_hsa003300.74968643
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74197728
61ErbB signaling pathway_Homo sapiens_hsa040120.73557047
62Bile secretion_Homo sapiens_hsa049760.72856634
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71813885
64beta-Alanine metabolism_Homo sapiens_hsa004100.70519851
65Olfactory transduction_Homo sapiens_hsa047400.68860210
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67337571
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.64795701
68Long-term depression_Homo sapiens_hsa047300.64626368
69Gap junction_Homo sapiens_hsa045400.64381210
70MAPK signaling pathway_Homo sapiens_hsa040100.61735992
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59509376
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59420598
73Glioma_Homo sapiens_hsa052140.58979713
74Sphingolipid metabolism_Homo sapiens_hsa006000.57685674
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.56107776
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55414664
77Ribosome_Homo sapiens_hsa030100.54844142
78Tyrosine metabolism_Homo sapiens_hsa003500.54663856
79Vitamin digestion and absorption_Homo sapiens_hsa049770.53580419
80Vitamin B6 metabolism_Homo sapiens_hsa007500.50329936
81Endocytosis_Homo sapiens_hsa041440.49127962
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48692226
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46036980
84Pancreatic secretion_Homo sapiens_hsa049720.45296064
85Choline metabolism in cancer_Homo sapiens_hsa052310.44822705
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43321148
87Regulation of autophagy_Homo sapiens_hsa041400.43123581
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.42628861
89Hedgehog signaling pathway_Homo sapiens_hsa043400.42332473
90Ras signaling pathway_Homo sapiens_hsa040140.41344979
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40920214
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40645798
93Folate biosynthesis_Homo sapiens_hsa007900.39313373
94Ovarian steroidogenesis_Homo sapiens_hsa049130.38581328
95Basal cell carcinoma_Homo sapiens_hsa052170.38571100
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38026078
97Hippo signaling pathway_Homo sapiens_hsa043900.37570150
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.35938679
99Inositol phosphate metabolism_Homo sapiens_hsa005620.35515745
100Lysosome_Homo sapiens_hsa041420.34884888

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