ZAN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of interleukin-12 biosynthetic process (GO:0045075)9.30759860
2cellular response to nicotine (GO:0071316)9.23324458
3response to muramyl dipeptide (GO:0032495)6.52449411
4regulation of hippo signaling (GO:0035330)5.50781164
5ribosomal small subunit biogenesis (GO:0042274)5.03847614
6tryptophan catabolic process (GO:0006569)5.00450287
7indole-containing compound catabolic process (GO:0042436)5.00450287
8indolalkylamine catabolic process (GO:0046218)5.00450287
9NAD biosynthetic process (GO:0009435)4.96049304
10peristalsis (GO:0030432)4.89703586
11DNA deamination (GO:0045006)4.87214854
12membrane protein intracellular domain proteolysis (GO:0031293)4.87148429
13indolalkylamine metabolic process (GO:0006586)4.77875595
14detection of light stimulus involved in sensory perception (GO:0050962)4.76950024
15detection of light stimulus involved in visual perception (GO:0050908)4.76950024
16transcription elongation from RNA polymerase III promoter (GO:0006385)4.63880552
17termination of RNA polymerase III transcription (GO:0006386)4.63880552
18monoubiquitinated protein deubiquitination (GO:0035520)4.59365743
19ribosomal large subunit biogenesis (GO:0042273)4.50164572
20kinetochore assembly (GO:0051382)4.43088183
21response to UV-B (GO:0010224)4.42937192
22negative regulation of calcium ion transport into cytosol (GO:0010523)4.36664900
23cilium or flagellum-dependent cell motility (GO:0001539)4.33305966
24kynurenine metabolic process (GO:0070189)4.32048651
25response to misfolded protein (GO:0051788)4.23587277
26rRNA modification (GO:0000154)4.22369507
27proteasome assembly (GO:0043248)4.08117158
28deoxyribonucleotide biosynthetic process (GO:0009263)4.04627520
29deoxyribonucleoside diphosphate metabolic process (GO:0009186)4.04128497
30indole-containing compound metabolic process (GO:0042430)4.03405211
31negative regulation of cAMP-mediated signaling (GO:0043951)4.01184625
32regulation of female gonad development (GO:2000194)4.00975264
33fusion of sperm to egg plasma membrane (GO:0007342)4.00340120
34kinetochore organization (GO:0051383)3.96453216
35positive regulation of interleukin-12 production (GO:0032735)3.95249981
367-methylguanosine mRNA capping (GO:0006370)3.95165268
37ribosomal small subunit assembly (GO:0000028)3.94279241
387-methylguanosine RNA capping (GO:0009452)3.92850771
39RNA capping (GO:0036260)3.92850771
40maturation of SSU-rRNA (GO:0030490)3.91518977
41transcription elongation from RNA polymerase I promoter (GO:0006362)3.89261356
42nucleoside diphosphate catabolic process (GO:0009134)3.86185117
43termination of RNA polymerase I transcription (GO:0006363)3.85990312
44pyridine nucleotide biosynthetic process (GO:0019363)3.85502329
45nicotinamide nucleotide biosynthetic process (GO:0019359)3.85502329
46tryptophan metabolic process (GO:0006568)3.85000107
47CENP-A containing nucleosome assembly (GO:0034080)3.81954703
48viral transcription (GO:0019083)3.80943645
49G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.80274249
50transcription from RNA polymerase I promoter (GO:0006360)3.80132768
51chromatin remodeling at centromere (GO:0031055)3.78344272
52DNA damage response, detection of DNA damage (GO:0042769)3.77868015
53spliceosomal complex assembly (GO:0000245)3.77624940
54deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.76544845
55multicellular organism reproduction (GO:0032504)3.73949651
56gonadal mesoderm development (GO:0007506)3.73658136
57ribonucleoprotein complex biogenesis (GO:0022613)3.72571971
58translational termination (GO:0006415)3.72276165
59spliceosomal snRNP assembly (GO:0000387)3.70720303
60cellular response to alkaloid (GO:0071312)3.65929066
61regulation of sarcomere organization (GO:0060297)3.65368440
62protein K48-linked deubiquitination (GO:0071108)3.64476656
63regulation of mitochondrial translation (GO:0070129)3.60111324
64GTP biosynthetic process (GO:0006183)3.53827737
65regulation of gene silencing by RNA (GO:0060966)3.52537767
66regulation of posttranscriptional gene silencing (GO:0060147)3.52537767
67regulation of gene silencing by miRNA (GO:0060964)3.52537767
68positive regulation of glial cell differentiation (GO:0045687)3.50101652
69telomere maintenance via semi-conservative replication (GO:0032201)3.48769801
70signal peptide processing (GO:0006465)3.46415264
71positive regulation of protein kinase C signaling (GO:0090037)3.46221882
72detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.44551760
73acrosome reaction (GO:0007340)3.44053762
74exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.42422831
75deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.40900162
76nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.39974108
77transcription-coupled nucleotide-excision repair (GO:0006283)3.38348104
78pseudouridine synthesis (GO:0001522)3.37483489
79microtubule severing (GO:0051013)3.37265004
80mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.37184457
81photoreceptor cell maintenance (GO:0045494)3.36749826
82cellular response to interleukin-6 (GO:0071354)3.36306484
83rRNA methylation (GO:0031167)3.36056081
84negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.35658948
85respiratory tube development (GO:0030323)3.34710656
86sperm motility (GO:0030317)3.34533699
87rRNA processing (GO:0006364)3.32529226
88regulation of skeletal muscle contraction (GO:0014819)3.31426766
89postsynaptic membrane organization (GO:0001941)3.31343225
90protein K6-linked ubiquitination (GO:0085020)3.31077106
91tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.28971710
92RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.28971710
93regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.28396078
94benzene-containing compound metabolic process (GO:0042537)3.27730407
95positive regulation of chondrocyte differentiation (GO:0032332)3.27306693
96establishment of integrated proviral latency (GO:0075713)3.27247076
97cellular component biogenesis (GO:0044085)3.26552050
98rRNA metabolic process (GO:0016072)3.23458968
99reflex (GO:0060004)3.22318065
100regulation of nuclear cell cycle DNA replication (GO:0033262)3.20204390
101establishment of protein localization to mitochondrial membrane (GO:0090151)3.18210931
102transcription initiation from RNA polymerase I promoter (GO:0006361)3.17730500
103behavioral response to nicotine (GO:0035095)3.17645442
104cotranslational protein targeting to membrane (GO:0006613)3.17073118
105SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.16863771
106DNA replication checkpoint (GO:0000076)3.15641438
107telomere maintenance via recombination (GO:0000722)3.14906123
108histone exchange (GO:0043486)3.14303181
109microtubule depolymerization (GO:0007019)3.14011941
110mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.13453927
111amine catabolic process (GO:0009310)3.13115181
112cellular biogenic amine catabolic process (GO:0042402)3.13115181
113ATP synthesis coupled proton transport (GO:0015986)3.12691505
114energy coupled proton transport, down electrochemical gradient (GO:0015985)3.12691505
115DNA-dependent DNA replication (GO:0006261)3.12645949
116auditory receptor cell stereocilium organization (GO:0060088)3.11839917
117protein targeting to ER (GO:0045047)3.11038421
118translation (GO:0006412)3.10758608
119protein-cofactor linkage (GO:0018065)3.10355192
120maturation of 5.8S rRNA (GO:0000460)3.10017543
121translational elongation (GO:0006414)3.06967510
122UTP biosynthetic process (GO:0006228)3.06795114
123RNA destabilization (GO:0050779)3.05966324
124serotonin metabolic process (GO:0042428)3.05751355
125DNA replication initiation (GO:0006270)3.04160607
126negative regulation of insulin receptor signaling pathway (GO:0046627)3.03048510
127chaperone-mediated protein transport (GO:0072321)3.02489827
128mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.02223779
129mitochondrial respiratory chain complex I assembly (GO:0032981)3.02223779
130NADH dehydrogenase complex assembly (GO:0010257)3.02223779
131regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)3.01836110
132positive regulation of CREB transcription factor activity (GO:0032793)3.01070168
133positive regulation of guanylate cyclase activity (GO:0031284)2.99689134
134positive regulation of steroid hormone secretion (GO:2000833)2.98762171
135regulation of double-strand break repair via homologous recombination (GO:0010569)2.97807641
136tachykinin receptor signaling pathway (GO:0007217)2.97701535
137protein neddylation (GO:0045116)2.97520591
138ribosome assembly (GO:0042255)2.97512938
139cellular protein complex disassembly (GO:0043624)2.96837191
140protein complex biogenesis (GO:0070271)2.95377266
141DNA integration (GO:0015074)2.95196413
142guanosine-containing compound biosynthetic process (GO:1901070)2.93664787
143mitotic metaphase plate congression (GO:0007080)2.93586564
144establishment of protein localization to endoplasmic reticulum (GO:0072599)2.93083967
145ribosome biogenesis (GO:0042254)2.91780120
146protein localization to endoplasmic reticulum (GO:0070972)2.91744086
147piRNA metabolic process (GO:0034587)2.91154539
148translational initiation (GO:0006413)2.88730934
149positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.88059641
150transcription elongation from RNA polymerase II promoter (GO:0006368)2.86224113
151DNA strand elongation involved in DNA replication (GO:0006271)2.85788580
152DNA replication-independent nucleosome assembly (GO:0006336)2.85144103
153DNA replication-independent nucleosome organization (GO:0034724)2.85144103
154viral life cycle (GO:0019058)2.85115152
155negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.84884238
156pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.84802995
157plasma membrane fusion (GO:0045026)2.84634494
158RNA methylation (GO:0001510)2.83640186
159meiotic chromosome segregation (GO:0045132)2.83452059
160regulation of guanylate cyclase activity (GO:0031282)2.82580990
161telomere maintenance via telomere lengthening (GO:0010833)2.82416095
162response to interleukin-6 (GO:0070741)2.82123452
163phosphate ion transport (GO:0006817)2.81830052
164positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.80918741
165positive regulation of viral transcription (GO:0050434)2.80817459
166DNA-templated transcription, elongation (GO:0006354)2.80489287
167misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.79191265
168protein K63-linked deubiquitination (GO:0070536)2.78915596
169DNA-templated transcription, termination (GO:0006353)2.78101771
170primary amino compound metabolic process (GO:1901160)2.76935002
171regulation of cAMP-mediated signaling (GO:0043949)2.75838407
172urinary tract smooth muscle contraction (GO:0014848)2.75762751
173negative regulation of cellular response to insulin stimulus (GO:1900077)2.75581916
174neuronal action potential (GO:0019228)2.75357767
175mitotic recombination (GO:0006312)2.75301648
176regulation of interleukin-12 production (GO:0032655)2.74066256
177cellular response to interleukin-1 (GO:0071347)2.73835290
178purine nucleoside diphosphate metabolic process (GO:0009135)2.73408937
179purine ribonucleoside diphosphate metabolic process (GO:0009179)2.73408937
180DNA strand elongation (GO:0022616)2.73286259
181placenta development (GO:0001890)2.70651605
182regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.70603312
183pyridine-containing compound biosynthetic process (GO:0072525)2.70165016
184behavioral response to pain (GO:0048266)2.69094478
185response to morphine (GO:0043278)2.68224773
186phasic smooth muscle contraction (GO:0014821)2.68033605
187glycine transport (GO:0015816)2.67966528
188positive regulation of gliogenesis (GO:0014015)2.67358491
189L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.65793170
190hydrogen peroxide biosynthetic process (GO:0050665)2.65380555
191purinergic nucleotide receptor signaling pathway (GO:0035590)2.65026563
192regulation of ruffle assembly (GO:1900027)2.63456581
193aromatic amino acid family catabolic process (GO:0009074)2.62255639
194righting reflex (GO:0060013)2.61662612
195DNA strand renaturation (GO:0000733)2.61373349
196membrane depolarization during action potential (GO:0086010)2.59813774
197detection of mechanical stimulus (GO:0050982)2.59661466
198DNA methylation involved in gamete generation (GO:0043046)2.58901441
199cytokine biosynthetic process (GO:0042089)2.58344162
200reproduction (GO:0000003)2.57916469

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.47746479
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.46680538
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.82606379
4* DROSHA_22980978_ChIP-Seq_HELA_Human3.80902118
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.75186088
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.49386919
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.46405345
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.37738235
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.28947564
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.24382498
11MYC_18555785_ChIP-Seq_MESCs_Mouse3.21132855
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.02481456
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.85648413
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.67603137
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.60672372
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.52956172
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.48491023
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.45542303
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.42324605
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.39767491
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.39118814
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.27492030
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.25947785
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.23640520
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.17244335
26IRF8_22096565_ChIP-ChIP_GC-B_Human2.16048381
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.14052321
28CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10663728
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.09430060
30ZNF274_21170338_ChIP-Seq_K562_Hela2.06810106
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.06136129
32VDR_23849224_ChIP-Seq_CD4+_Human2.04267595
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.98170937
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.92452522
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.90816350
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.90058626
37AR_21572438_ChIP-Seq_LNCaP_Human1.87836795
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.87015204
39VDR_22108803_ChIP-Seq_LS180_Human1.86180392
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.85817666
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83253050
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81996404
43JARID2_20075857_ChIP-Seq_MESCs_Mouse1.81451921
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.77659647
45ELK1_19687146_ChIP-ChIP_HELA_Human1.76728015
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.74768510
47OCT4_20526341_ChIP-Seq_ESCs_Human1.74701279
48* E2F1_20622854_ChIP-Seq_HELA_Human1.70405566
49TTF2_22483619_ChIP-Seq_HELA_Human1.69462283
50GBX2_23144817_ChIP-Seq_PC3_Human1.66257027
51VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.65823223
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64804006
53XRN2_22483619_ChIP-Seq_HELA_Human1.61823096
54EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.60884620
55SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.60767641
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60325636
57YY1_22570637_ChIP-Seq_MALME-3M_Human1.59634358
58* BCL6_27268052_Chip-Seq_Bcells_Human1.58169133
59P68_20966046_ChIP-Seq_HELA_Human1.58072804
60DCP1A_22483619_ChIP-Seq_HELA_Human1.57158185
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56177123
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54388527
63IGF1R_20145208_ChIP-Seq_DFB_Human1.53590898
64* BCOR_27268052_Chip-Seq_Bcells_Human1.53283714
65E2F1_18555785_ChIP-Seq_MESCs_Mouse1.53125645
66FOXP3_21729870_ChIP-Seq_TREG_Human1.52932219
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.52169331
68FUS_26573619_Chip-Seq_HEK293_Human1.50923037
69REST_21632747_ChIP-Seq_MESCs_Mouse1.49693873
70ERA_21632823_ChIP-Seq_H3396_Human1.49070501
71RAC3_21632823_ChIP-Seq_H3396_Human1.49030319
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48463116
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.48165010
74KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.48165010
75KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.48165010
76ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.46616475
77* CTCF_20526341_ChIP-Seq_ESCs_Human1.44334898
78GATA1_22025678_ChIP-Seq_K562_Human1.44147025
79* PHF8_20622854_ChIP-Seq_HELA_Human1.43832513
80NELFA_20434984_ChIP-Seq_ESCs_Mouse1.42105074
81ERG_21242973_ChIP-ChIP_JURKAT_Human1.41454494
82MYC_18940864_ChIP-ChIP_HL60_Human1.40717898
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39883780
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39588009
85FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39432459
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38502913
87* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.38151945
88IKZF1_21737484_ChIP-ChIP_HCT116_Human1.37999354
89NFE2_27457419_Chip-Seq_LIVER_Mouse1.37452671
90SMC4_20622854_ChIP-Seq_HELA_Human1.37449204
91ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37363563
92* P300_27268052_Chip-Seq_Bcells_Human1.36874381
93IRF1_19129219_ChIP-ChIP_H3396_Human1.35845534
94ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.35686697
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35123378
96TAF2_19829295_ChIP-Seq_ESCs_Human1.34492304
97STAT3_23295773_ChIP-Seq_U87_Human1.34458263
98IRF8_21731497_ChIP-ChIP_J774_Mouse1.34196295
99EZH2_27294783_Chip-Seq_ESCs_Mouse1.33911875
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33007929
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33007929
102YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32643530
103WDR5_24793694_ChIP-Seq_LNCAP_Human1.32210957
104NANOG_20526341_ChIP-Seq_ESCs_Human1.31887155
105RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.30861299
106NOTCH1_21737748_ChIP-Seq_TLL_Human1.30233532
107KAP1_22055183_ChIP-Seq_ESCs_Mouse1.28915648
108* MYC_19829295_ChIP-Seq_ESCs_Human1.28650911
109P53_21459846_ChIP-Seq_SAOS-2_Human1.27647921
110* SMAD3_21741376_ChIP-Seq_ESCs_Human1.26137604
111PRDM14_20953172_ChIP-Seq_ESCs_Human1.26059581
112NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25005024
113SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24898240
114ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24504994
115* ER_23166858_ChIP-Seq_MCF-7_Human1.24071597
116SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.20377007
117* ELF1_20517297_ChIP-Seq_JURKAT_Human1.17987520
118ELK1_22589737_ChIP-Seq_MCF10A_Human1.17598052
119E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.15711339
120EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.15518179
121ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14852280
122PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14470766
123CTCF_27219007_Chip-Seq_Bcells_Human1.14459761
124OCT1_27270436_Chip-Seq_PROSTATE_Human1.13716924
125EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13363579
126UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12780367
127GATA3_21878914_ChIP-Seq_MCF-7_Human1.12391025
128PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12292683
129MYCN_18555785_ChIP-Seq_MESCs_Mouse1.11745534
130EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.11716140
131KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10571800
132LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10159275
133LXR_22292898_ChIP-Seq_THP-1_Human1.09522543
134SCL_19346495_ChIP-Seq_HPC-7_Human1.08760862
135* SMAD4_21741376_ChIP-Seq_EPCs_Human1.07525445
136P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06648648
137CBX2_27304074_Chip-Seq_ESCs_Mouse1.06103735
138GABP_19822575_ChIP-Seq_HepG2_Human1.05945445
139PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.05317236
140SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04727540
141MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04491016
142FOXA1_25329375_ChIP-Seq_VCAP_Human1.04342295
143FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04342295
144TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.02917417
145* STAT1_17558387_ChIP-Seq_HELA_Human1.01811432
146STAT3_18555785_Chip-Seq_ESCs_Mouse1.01625755
147KLF4_19829295_ChIP-Seq_ESCs_Human1.01051713
148BCAT_22108803_ChIP-Seq_LS180_Human1.00502792
149RUNX2_22187159_ChIP-Seq_PCA_Human1.00489302
150ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00203483
151EED_16625203_ChIP-ChIP_MESCs_Mouse0.99982982
152CEBPB_22108803_ChIP-Seq_LS180_Human0.99329107
153NANOG_19829295_ChIP-Seq_ESCs_Human0.98500121
154SOX2_19829295_ChIP-Seq_ESCs_Human0.98500121
155EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98085218
156RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98085218
157NMYC_18555785_Chip-Seq_ESCs_Mouse0.97958769
158EZH2_22144423_ChIP-Seq_EOC_Human0.97733969
159EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97649373
160P300_18555785_Chip-Seq_ESCs_Mouse0.97253452
161* OCT4_19829295_ChIP-Seq_ESCs_Human0.96957468
162SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96384996
163POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95840572
164BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95526603
165EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95515165
166TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95278563
167EZH2_27294783_Chip-Seq_NPCs_Mouse0.94856723
168NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94837667
169EWS_26573619_Chip-Seq_HEK293_Human0.94344124
170ZFX_18555785_Chip-Seq_ESCs_Mouse0.94266449
171GATA1_26923725_Chip-Seq_HPCs_Mouse0.93950951
172KLF4_18555785_Chip-Seq_ESCs_Mouse0.93917778
173STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93698975
174NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.93682361
175GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93588454
176GATA3_21867929_ChIP-Seq_CD8_Mouse0.93353514
177NCOR_22424771_ChIP-Seq_293T_Human0.92724450
178* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92662561
179JARID2_20064375_ChIP-Seq_MESCs_Mouse0.92538908
180* E2F1_18555785_Chip-Seq_ESCs_Mouse0.90614297
181RNF2_27304074_Chip-Seq_NSC_Mouse0.90403527
182SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89977932
183CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.89815952
184RUNX1_27457419_Chip-Seq_LIVER_Mouse0.89736248
185NANOG_18555785_Chip-Seq_ESCs_Mouse0.88997680
186OCT4_18555785_Chip-Seq_ESCs_Mouse0.88797326
187SOX2_16153702_ChIP-ChIP_HESCs_Human0.88787563
188P53_22387025_ChIP-Seq_ESCs_Mouse0.87297893
189SOX17_20123909_ChIP-Seq_XEN_Mouse0.87187768
190HOXB4_20404135_ChIP-ChIP_EML_Mouse0.85285437
191SOX2_18555785_Chip-Seq_ESCs_Mouse0.84454629
192* SMAD1_18555785_Chip-Seq_ESCs_Mouse0.84216339
193ESRRB_18555785_Chip-Seq_ESCs_Mouse0.83126319

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004510_myositis8.95628173
2MP0008057_abnormal_DNA_replication3.17186162
3MP0003693_abnormal_embryo_hatching3.10123353
4MP0009379_abnormal_foot_pigmentation3.08654456
5MP0001501_abnormal_sleep_pattern3.06234366
6MP0003136_yellow_coat_color3.05261219
7MP0008058_abnormal_DNA_repair3.04621322
8MP0006292_abnormal_olfactory_placode3.01111899
9MP0001188_hyperpigmentation2.99137502
10MP0003195_calcinosis2.86342475
11MP0005670_abnormal_white_adipose2.82312640
12MP0000566_synostosis2.80027172
13MP0003111_abnormal_nucleus_morphology2.69681301
14MP0001853_heart_inflammation2.68170169
15MP0003718_maternal_effect2.66720756
16MP0008877_abnormal_DNA_methylation2.64632426
17MP0005171_absent_coat_pigmentation2.51584329
18MP0010094_abnormal_chromosome_stability2.48489338
19MP0002102_abnormal_ear_morphology2.25436407
20MP0004381_abnormal_hair_follicle2.19024396
21MP0003786_premature_aging2.14585664
22MP0008932_abnormal_embryonic_tissue2.13127921
23MP0002277_abnormal_respiratory_mucosa2.11424443
24MP0004957_abnormal_blastocyst_morpholog2.04706757
25MP0003315_abnormal_perineum_morphology2.01871963
26MP0003077_abnormal_cell_cycle1.98975096
27MP0005409_darkened_coat_color1.98565285
28MP0002138_abnormal_hepatobiliary_system1.92027268
29MP0003183_abnormal_peptide_metabolism1.87414135
30MP0005167_abnormal_blood-brain_barrier1.85428768
31MP0003941_abnormal_skin_development1.81052507
32MP0001529_abnormal_vocalization1.77960918
33MP0004043_abnormal_pH_regulation1.76350667
34MP0001986_abnormal_taste_sensitivity1.74203576
35MP0003646_muscle_fatigue1.74194842
36MP0003866_abnormal_defecation1.68826889
37MP0003172_abnormal_lysosome_physiology1.68759495
38MP0008995_early_reproductive_senescence1.63757514
39MP0002132_abnormal_respiratory_system1.62632216
40MP0002090_abnormal_vision1.62597540
41MP0003880_abnormal_central_pattern1.61981132
42MP0001905_abnormal_dopamine_level1.59193203
43MP0005410_abnormal_fertilization1.54750303
44MP0001348_abnormal_lacrimal_gland1.53000278
45MP0006054_spinal_hemorrhage1.52239938
46MP0002938_white_spotting1.49603205
47MP0002638_abnormal_pupillary_reflex1.46626347
48MP0005423_abnormal_somatic_nervous1.45563877
49MP0002210_abnormal_sex_determination1.43031332
50MP0003938_abnormal_ear_development1.42272379
51MP0010368_abnormal_lymphatic_system1.42194427
52MP0004133_heterotaxia1.39218431
53MP0005451_abnormal_body_composition1.38322755
54MP0002928_abnormal_bile_duct1.35738090
55MP0002160_abnormal_reproductive_system1.34573078
56MP0001968_abnormal_touch/_nociception1.32973098
57MP0001485_abnormal_pinna_reflex1.32539683
58MP0000733_abnormal_muscle_development1.32200624
59MP0008007_abnormal_cellular_replicative1.28540772
60MP0002405_respiratory_system_inflammati1.28222203
61MP0009745_abnormal_behavioral_response1.27716666
62MP0009046_muscle_twitch1.26575385
63MP0004142_abnormal_muscle_tone1.26450741
64MP0000372_irregular_coat_pigmentation1.25332798
65MP0005075_abnormal_melanosome_morpholog1.24254118
66MP0001929_abnormal_gametogenesis1.24242954
67MP0002822_catalepsy1.23889705
68MP0005379_endocrine/exocrine_gland_phen1.22061465
69MP0004147_increased_porphyrin_level1.21623037
70MP0005551_abnormal_eye_electrophysiolog1.21229075
71MP0000613_abnormal_salivary_gland1.20766802
72MP0002733_abnormal_thermal_nociception1.20551719
73MP0003633_abnormal_nervous_system1.20276477
74MP0002249_abnormal_larynx_morphology1.17774460
75MP0005389_reproductive_system_phenotype1.15827614
76MP0001145_abnormal_male_reproductive1.15716521
77MP0001800_abnormal_humoral_immune1.14774130
78MP0009765_abnormal_xenobiotic_induced1.14349868
79MP0005377_hearing/vestibular/ear_phenot1.14092093
80MP0003878_abnormal_ear_physiology1.14092093
81MP0006072_abnormal_retinal_apoptosis1.14004680
82MP0000026_abnormal_inner_ear1.13397041
83MP0002163_abnormal_gland_morphology1.13036179
84MP0008872_abnormal_physiological_respon1.12382545
85MP0005645_abnormal_hypothalamus_physiol1.12055746
86MP0005253_abnormal_eye_physiology1.11640206
87MP0002572_abnormal_emotion/affect_behav1.11586964
88MP0002139_abnormal_hepatobiliary_system1.10890101
89MP0000049_abnormal_middle_ear1.10686876
90* MP0003698_abnormal_male_reproductive1.08920274
91MP0003787_abnormal_imprinting1.08094934
92MP0005387_immune_system_phenotype1.07931706
93MP0001790_abnormal_immune_system1.07931706
94MP0008004_abnormal_stomach_pH1.07236642
95MP0000762_abnormal_tongue_morphology1.06963232
96MP0000653_abnormal_sex_gland1.06439588
97MP0003879_abnormal_hair_cell1.05346057
98MP0006276_abnormal_autonomic_nervous1.03454547
99MP0002751_abnormal_autonomic_nervous1.02294347
100MP0010030_abnormal_orbit_morphology1.02012990
101MP0003045_fibrosis1.01413772
102MP0001764_abnormal_homeostasis0.99964316
103MP0005174_abnormal_tail_pigmentation0.99281745
104MP0008875_abnormal_xenobiotic_pharmacok0.99062205
105MP0005671_abnormal_response_to0.97642548
106MP0003950_abnormal_plasma_membrane0.96963770
107MP0002752_abnormal_somatic_nervous0.96520568
108MP0001970_abnormal_pain_threshold0.96108267
109MP0001963_abnormal_hearing_physiology0.93826484
110MP0002557_abnormal_social/conspecific_i0.92963271
111MP0000678_abnormal_parathyroid_gland0.92871995
112MP0001346_abnormal_lacrimal_gland0.91557297
113MP0000015_abnormal_ear_pigmentation0.91151930
114MP0003937_abnormal_limbs/digits/tail_de0.91064735
115MP0001286_abnormal_eye_development0.90121794
116MP0008789_abnormal_olfactory_epithelium0.88443690
117MP0001293_anophthalmia0.87822721
118MP0001919_abnormal_reproductive_system0.87551886
119MP0003011_delayed_dark_adaptation0.87029915
120MP0003119_abnormal_digestive_system0.86685243
121MP0008770_decreased_survivor_rate0.86528506
122MP0005646_abnormal_pituitary_gland0.86474420
123MP0002067_abnormal_sensory_capabilities0.86005363
124MP0010155_abnormal_intestine_physiology0.85141275
125MP0001727_abnormal_embryo_implantation0.85063115
126MP0001486_abnormal_startle_reflex0.84403140
127MP0000462_abnormal_digestive_system0.84239902
128MP0002653_abnormal_ependyma_morphology0.84157208
129MP0002736_abnormal_nociception_after0.82717159
130MP0005647_abnormal_sex_gland0.81831791
131MP0001765_abnormal_ion_homeostasis0.79862521
132MP0001119_abnormal_female_reproductive0.77931088
133MP0000470_abnormal_stomach_morphology0.77561827
134MP0005395_other_phenotype0.77238337
135MP0002148_abnormal_hypersensitivity_rea0.77236264
136MP0003936_abnormal_reproductive_system0.77234235
137MP0003303_peritoneal_inflammation0.76466059
138MP0009278_abnormal_bone_marrow0.76244047
139MP0002876_abnormal_thyroid_physiology0.75118709
140MP0002452_abnormal_antigen_presenting0.74140385
141MP0000490_abnormal_crypts_of0.72873623
142MP0003631_nervous_system_phenotype0.72742686
143MP0003186_abnormal_redox_activity0.72236591
144MP0005310_abnormal_salivary_gland0.71775052
145MP0002095_abnormal_skin_pigmentation0.71226734
146MP0005391_vision/eye_phenotype0.71184382
147MP0002229_neurodegeneration0.70572739
148MP0005083_abnormal_biliary_tract0.70558242
149MP0000538_abnormal_urinary_bladder0.70111412
150MP0000230_abnormal_systemic_arterial0.69806045
151MP0002723_abnormal_immune_serum0.69438683
152MP0001440_abnormal_grooming_behavior0.69027965
153MP0003635_abnormal_synaptic_transmissio0.68635844
154MP0002735_abnormal_chemical_nociception0.66822459
155MP0003123_paternal_imprinting0.66547321
156MP0001849_ear_inflammation0.65909178
157MP0005408_hypopigmentation0.65472946
158MP0005499_abnormal_olfactory_system0.65125876
159MP0005394_taste/olfaction_phenotype0.65125876
160MP0009643_abnormal_urine_homeostasis0.64907633
161MP0004742_abnormal_vestibular_system0.64257976
162MP0001186_pigmentation_phenotype0.63479182
163MP0003638_abnormal_response/metabolism_0.63048583
164MP0002233_abnormal_nose_morphology0.61892738
165MP0000313_abnormal_cell_death0.61498671
166MP0003121_genomic_imprinting0.61495579
167MP0005195_abnormal_posterior_eye0.60752008

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)5.39955062
2Decreased central vision (HP:0007663)4.94432588
3Genetic anticipation (HP:0003743)4.84918073
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.74571763
5Chromsome breakage (HP:0040012)4.29738906
6Reticulocytopenia (HP:0001896)4.03419228
7Bony spicule pigmentary retinopathy (HP:0007737)4.03086529
8Duplicated collecting system (HP:0000081)3.85381685
9Retinal dysplasia (HP:0007973)3.85342327
10Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.83541865
11Central scotoma (HP:0000603)3.70632515
12Progressive external ophthalmoplegia (HP:0000590)3.62031274
13Abnormality of binocular vision (HP:0011514)3.58058866
14Diplopia (HP:0000651)3.58058866
15Abnormality of the renal collecting system (HP:0004742)3.48485617
16Pendular nystagmus (HP:0012043)3.44508921
17Proximal tubulopathy (HP:0000114)3.34181741
18Breast hypoplasia (HP:0003187)3.31656190
19Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.26291968
20Birth length less than 3rd percentile (HP:0003561)3.25045926
21Progressive cerebellar ataxia (HP:0002073)3.23968678
22Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.22705592
23Acute necrotizing encephalopathy (HP:0006965)3.14100268
24Hypoplastic ischia (HP:0003175)3.12802555
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.12127114
26Meckel diverticulum (HP:0002245)3.09591702
27Generalized aminoaciduria (HP:0002909)3.08565570
28Increased neuronal autofluorescent lipopigment (HP:0002074)3.07997557
29Enlarged epiphyses (HP:0010580)3.05340202
30Choroideremia (HP:0001139)3.00957426
31Abnormality of the preputium (HP:0100587)2.95529504
32Abnormality of the ileum (HP:0001549)2.95054768
33Gaze-evoked nystagmus (HP:0000640)2.91858975
343-Methylglutaconic aciduria (HP:0003535)2.91536463
35Mitochondrial inheritance (HP:0001427)2.91251466
36Poikiloderma (HP:0001029)2.90205525
37Absent radius (HP:0003974)2.88292610
38Increased hepatocellular lipid droplets (HP:0006565)2.87565487
39Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.85500652
40Abnormality of alanine metabolism (HP:0010916)2.85500652
41Hyperalaninemia (HP:0003348)2.85500652
42Abnormality of macular pigmentation (HP:0008002)2.79712585
43Abolished electroretinogram (ERG) (HP:0000550)2.78498018
44Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.77777884
45Aplasia involving forearm bones (HP:0009822)2.75300613
46Absent forearm bone (HP:0003953)2.75300613
47Dysmetric saccades (HP:0000641)2.73525427
48Renal Fanconi syndrome (HP:0001994)2.70047510
49Macrocytic anemia (HP:0001972)2.69164476
50Aplasia/Hypoplasia involving the musculature (HP:0001460)2.68759386
51Clumsiness (HP:0002312)2.65711986
52Microvesicular hepatic steatosis (HP:0001414)2.64256239
53Abnormality of cells of the erythroid lineage (HP:0012130)2.64006152
54Absent/shortened dynein arms (HP:0200106)2.61439044
55Dynein arm defect of respiratory motile cilia (HP:0012255)2.61439044
56Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.60931282
57Abnormal protein N-linked glycosylation (HP:0012347)2.60931282
58Abnormal protein glycosylation (HP:0012346)2.60931282
59Abnormal glycosylation (HP:0012345)2.60931282
60Progressive macrocephaly (HP:0004481)2.60634924
61J-shaped sella turcica (HP:0002680)2.60551542
62Increased cerebral lipofuscin (HP:0011813)2.58526025
63Aplasia/Hypoplasia of the uvula (HP:0010293)2.57987230
64Abnormality of the ischium (HP:0003174)2.57214469
65Aplasia/Hypoplasia of the sacrum (HP:0008517)2.57133872
66Triphalangeal thumb (HP:0001199)2.54604236
67Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.53592078
68Scotoma (HP:0000575)2.51181371
69Keratoconus (HP:0000563)2.50080199
70Increased corneal curvature (HP:0100692)2.50080199
71Mesangial abnormality (HP:0001966)2.50046251
72Increased CSF lactate (HP:0002490)2.50000837
73Recurrent pneumonia (HP:0006532)2.49804113
74Septo-optic dysplasia (HP:0100842)2.48042955
75Abnormal rod and cone electroretinograms (HP:0008323)2.47661381
76Abnormal mitochondria in muscle tissue (HP:0008316)2.46852202
77Pallor (HP:0000980)2.46206655
78Prolonged partial thromboplastin time (HP:0003645)2.44364046
79Absent thumb (HP:0009777)2.42780022
80Aplasia/hypoplasia of the uterus (HP:0008684)2.42038343
81Abnormal number of erythroid precursors (HP:0012131)2.40607621
82Macular degeneration (HP:0000608)2.40068040
83Abnormality of chromosome stability (HP:0003220)2.38193841
84Cerebral hypomyelination (HP:0006808)2.35734483
85Chronic sinusitis (HP:0011109)2.35165436
86Hepatocellular necrosis (HP:0001404)2.32114371
87Abnormality of the intrinsic pathway (HP:0010989)2.31645918
88Ectopic kidney (HP:0000086)2.29689871
89Horseshoe kidney (HP:0000085)2.29191661
90Carpal bone hypoplasia (HP:0001498)2.29044708
91Abnormality of the septum pellucidum (HP:0007375)2.28265487
92Agammaglobulinemia (HP:0004432)2.28157388
93Pancreatic cysts (HP:0001737)2.27517989
94Acute encephalopathy (HP:0006846)2.27509664
95Constricted visual fields (HP:0001133)2.27100012
96Amniotic constriction ring (HP:0009775)2.25527472
97Abnormality of placental membranes (HP:0011409)2.25527472
98Lipid accumulation in hepatocytes (HP:0006561)2.24846321
99Malignant hyperthermia (HP:0002047)2.23540536
100Hemorrhage of the eye (HP:0011885)2.22935777
101Patellar aplasia (HP:0006443)2.22879130
102Hyperkalemia (HP:0002153)2.21477985
103Aplasia/Hypoplasia of the earlobes (HP:0009906)2.19948300
104Increased serum lactate (HP:0002151)2.18430021
105Exertional dyspnea (HP:0002875)2.16738494
106Aplasia/Hypoplasia of the patella (HP:0006498)2.16315871
107Abnormality of DNA repair (HP:0003254)2.15464560
108Asplenia (HP:0001746)2.15146130
109Duplication of thumb phalanx (HP:0009942)2.15044276
110Optic disc pallor (HP:0000543)2.14150606
111Exercise intolerance (HP:0003546)2.13090647
112Stomach cancer (HP:0012126)2.11369607
113Aplasia of the musculature (HP:0100854)2.10905786
114Abnormal respiratory epithelium morphology (HP:0012253)2.09945283
115Abnormal respiratory motile cilium morphology (HP:0005938)2.09945283
116Attenuation of retinal blood vessels (HP:0007843)2.09790915
117Dyschromatopsia (HP:0007641)2.09447465
118Sclerocornea (HP:0000647)2.07650360
119External ophthalmoplegia (HP:0000544)2.07362215
120Ileus (HP:0002595)2.07279010
121Impulsivity (HP:0100710)2.06928769
122Abnormality of renal resorption (HP:0011038)2.05560253
123True hermaphroditism (HP:0010459)2.05381887
124Thoracolumbar scoliosis (HP:0002944)2.03269775
125Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.02752913
126Absent epiphyses (HP:0010577)2.02752913
127Abnormal spermatogenesis (HP:0008669)2.01463434
128Abnormality of the axillary hair (HP:0100134)2.00989763
129Abnormality of secondary sexual hair (HP:0009888)2.00989763
130Decreased activity of mitochondrial respiratory chain (HP:0008972)1.99779559
131Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.99779559
132Supernumerary spleens (HP:0009799)1.98891454
133Impaired smooth pursuit (HP:0007772)1.98203282
134Pancreatic fibrosis (HP:0100732)1.97478549
135Nephroblastoma (Wilms tumor) (HP:0002667)1.97181872
136Recurrent bronchitis (HP:0002837)1.95644664
137Polydipsia (HP:0001959)1.93899528
138Abnormal drinking behavior (HP:0030082)1.93899528
139Parakeratosis (HP:0001036)1.93680935
140Abnormality of the pubic bones (HP:0003172)1.93408751
141Duodenal stenosis (HP:0100867)1.92677141
142Small intestinal stenosis (HP:0012848)1.92677141
143Rough bone trabeculation (HP:0100670)1.91309305
144Abnormal ciliary motility (HP:0012262)1.90804674
145Congenital sensorineural hearing impairment (HP:0008527)1.90751259
146Bell-shaped thorax (HP:0001591)1.90361304
147Decreased electroretinogram (ERG) amplitude (HP:0000654)1.90258915
148Aplasia/Hypoplasia of the spleen (HP:0010451)1.89308864
149Type I transferrin isoform profile (HP:0003642)1.89236564
150Cervical subluxation (HP:0003308)1.88890458
151Bone marrow hypocellularity (HP:0005528)1.88358947
152Clubbing of toes (HP:0100760)1.88091318
153Stenosis of the external auditory canal (HP:0000402)1.87986128
154Hypoplasia of the iris (HP:0007676)1.87908389
155Absent septum pellucidum (HP:0001331)1.87905751
156Embryonal renal neoplasm (HP:0011794)1.86954065
157Short thumb (HP:0009778)1.86376925
158Optic nerve hypoplasia (HP:0000609)1.85430347
159Type 2 muscle fiber atrophy (HP:0003554)1.85154775
160Congenital stationary night blindness (HP:0007642)1.84046611
161Abnormality of the renal medulla (HP:0100957)1.83471637
162Cystic liver disease (HP:0006706)1.83343002
163Autoimmune thrombocytopenia (HP:0001973)1.83205843
164Abnormality of the vitreous humor (HP:0004327)1.83159687
165Conical tooth (HP:0000698)1.83143644
166Facial hemangioma (HP:0000329)1.83133509
167Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.82736641
168Congenital ichthyosiform erythroderma (HP:0007431)1.81287794
169Dysautonomia (HP:0002459)1.80827805
170Cone-rod dystrophy (HP:0000548)1.80801727
171Congenital hepatic fibrosis (HP:0002612)1.79876381
172Nephronophthisis (HP:0000090)1.79380471
173Abnormality of the hepatic vasculature (HP:0006707)1.75327584
174Capillary hemangiomas (HP:0005306)1.70308712
175Intestinal fistula (HP:0100819)1.69184703
176Absent rod-and cone-mediated responses on ERG (HP:0007688)1.68577277
177Difficulty walking (HP:0002355)1.67247037
178Broad face (HP:0000283)1.63534510
179Rectovaginal fistula (HP:0000143)1.63113300
180Rectal fistula (HP:0100590)1.63113300
181Abnormality of the diencephalon (HP:0010662)1.62318589
182Cerebellar dysplasia (HP:0007033)1.61980813
183Facial diplegia (HP:0001349)1.61819843

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RPS6KA47.29280424
2FRK5.41828176
3IRAK34.50700245
4STK164.21980255
5IKBKE3.94948466
6PLK43.72053105
7TBK13.60903863
8INSRR3.47670176
9BUB13.44509051
10DDR23.22072150
11MAPK153.09379967
12ZAK3.01024577
13SRPK12.96613412
14CDK122.68865493
15WEE12.59984227
16RPS6KA62.48907217
17PNCK2.39499182
18MARK12.38457237
19TLK12.36052885
20CHUK2.23670728
21CAMK42.23330257
22EIF2AK12.17005981
23IRAK42.11789970
24PBK2.10524182
25PIM12.08721971
26MKNK21.95123267
27VRK11.93792616
28IRAK21.88791280
29IRAK11.74008044
30TNIK1.72287797
31CASK1.71336875
32NME11.67304082
33ACVR1B1.66572820
34TTK1.65974456
35KIT1.64913546
36MKNK11.63029961
37NTRK31.62418376
38EPHA21.54125266
39EIF2AK31.52517627
40EIF2AK21.49174106
41MAP4K11.48673558
42TAOK31.45397810
43PINK11.41986667
44NEK61.38709115
45TNK21.35650282
46TAF11.34198342
47BLK1.28834918
48AKT31.24679769
49PLK11.22965047
50STK391.18927515
51GRK11.17422597
52STK38L1.15635221
53CHEK21.13934330
54CSF1R1.13612377
55ADRBK21.10530963
56MST41.10516814
57PLK31.10479247
58NME21.09316268
59MAP3K141.03548184
60TSSK60.99541675
61DYRK20.90186216
62AURKA0.88499583
63PIK3CG0.87488310
64NUAK10.83712955
65PRKCZ0.83311525
66OXSR10.81751594
67ATR0.81112344
68BMPR1B0.75748373
69AURKB0.75348187
70BCR0.75321128
71CDK70.74284745
72BRSK20.73086131
73YES10.73017961
74CDC70.71733024
75GRK70.71508932
76CAMK2B0.69347966
77BMPR20.65250395
78VRK20.65231901
79PKN10.65052092
80DYRK30.64800919
81FLT30.64501699
82BRAF0.63775720
83PRKCI0.63551226
84BRD40.62658852
85ADRBK10.62025958
86CDK30.61974238
87ICK0.61236455
88MAP3K130.61227939
89SYK0.61144052
90RPS6KC10.60456706
91RPS6KL10.60456706
92MUSK0.59635120
93CSNK2A10.59491374
94LYN0.59171606
95TXK0.58930126
96PTK2B0.58656798
97PLK20.58471686
98KDR0.58076196
99STK380.57687658
100NLK0.56964827
101CLK10.56232466
102DAPK10.55077312
103ABL20.54765528
104CHEK10.54423342
105CDK190.52168822
106EEF2K0.51821984
107CAMK2D0.50746933
108RPS6KA50.50076029
109ATM0.49635593
110CDK80.48708281
111CSNK2A20.48215800
112FES0.48077522
113NEK20.47743806
114RIPK40.47536487
115MAPK70.47325850
116SIK20.47191578
117SMG10.46113695
118TESK20.45792507
119IKBKB0.45617430
120PRKCH0.45163136
121MAP3K110.44502803
122MARK30.43893369
123LCK0.42991140
124MAPK130.41704720
125ZAP700.40976370
126CAMK2G0.39816486
127MAPK110.39721358
128MAP2K70.39308433
129CDK40.38221305
130PRKAA20.36685235
131BMX0.36306204
132MATK0.34621700
133RPS6KB20.34313128
134CDK10.33877148
135NTRK20.33794536
136DAPK20.32435942
137WNK40.32349208
138PRKAA10.31429725
139TAOK20.30952582
140STK40.30545856
141PHKG20.30091328
142PHKG10.30091328
143CDK20.29272407
144PRPF4B0.28993817
145MAPKAPK50.28815234
146CAMK2A0.28661878
147PRKCE0.28015672
148CSNK1D0.27599620
149PRKD20.27364824
150PRKACA0.27067948
151RPS6KA20.26749758
152CSNK1E0.26721954
153TYRO30.26439093
154GSK3B0.24858533
155PAK10.24759026
156PASK0.24704198
157PRKD10.24632569
158TGFBR10.24563213
159BRSK10.24553532
160BTK0.24209796
161MAPK10.23793637
162CCNB10.23643460
163MAPK140.23461469
164EPHA40.23338651
165MAP3K120.23303906
166PRKDC0.21785181
167PRKCG0.21713199
168RPS6KA10.21674232
169CSNK1A10.20682860
170PDK20.19903933

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.55959245
2RNA polymerase_Homo sapiens_hsa030204.41128839
3Proteasome_Homo sapiens_hsa030503.47920187
4Fanconi anemia pathway_Homo sapiens_hsa034603.15741429
5DNA replication_Homo sapiens_hsa030303.12340741
6Homologous recombination_Homo sapiens_hsa034403.02846909
7Oxidative phosphorylation_Homo sapiens_hsa001903.01556078
8Mismatch repair_Homo sapiens_hsa034302.96162079
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.93500688
10Pyrimidine metabolism_Homo sapiens_hsa002402.80584543
11Spliceosome_Homo sapiens_hsa030402.61021113
12Cocaine addiction_Homo sapiens_hsa050302.55757732
13Parkinsons disease_Homo sapiens_hsa050122.38082364
14ABC transporters_Homo sapiens_hsa020102.35918115
15Huntingtons disease_Homo sapiens_hsa050162.25578245
16Basal transcription factors_Homo sapiens_hsa030222.22780728
17Nucleotide excision repair_Homo sapiens_hsa034202.22455413
18Tryptophan metabolism_Homo sapiens_hsa003801.97592810
19B cell receptor signaling pathway_Homo sapiens_hsa046621.91378810
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.84640648
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.83742716
22African trypanosomiasis_Homo sapiens_hsa051431.82155442
23Purine metabolism_Homo sapiens_hsa002301.79860412
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.76706225
25RNA transport_Homo sapiens_hsa030131.75276916
26Non-homologous end-joining_Homo sapiens_hsa034501.74156549
27Alzheimers disease_Homo sapiens_hsa050101.69830496
28Butanoate metabolism_Homo sapiens_hsa006501.69263223
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.68722171
30Base excision repair_Homo sapiens_hsa034101.66854680
31Selenocompound metabolism_Homo sapiens_hsa004501.63691377
32Protein export_Homo sapiens_hsa030601.62935722
33Phototransduction_Homo sapiens_hsa047441.62224011
34RNA degradation_Homo sapiens_hsa030181.58435925
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.53064583
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.44378613
37One carbon pool by folate_Homo sapiens_hsa006701.43551661
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.40631686
39Cell cycle_Homo sapiens_hsa041101.39886806
40Morphine addiction_Homo sapiens_hsa050321.37828004
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.36186429
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.35614738
43Adipocytokine signaling pathway_Homo sapiens_hsa049201.34289225
44Nitrogen metabolism_Homo sapiens_hsa009101.32613354
45Leishmaniasis_Homo sapiens_hsa051401.28802181
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.23243518
47Arachidonic acid metabolism_Homo sapiens_hsa005901.22759376
48TNF signaling pathway_Homo sapiens_hsa046681.20922384
49Olfactory transduction_Homo sapiens_hsa047401.18127043
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.17534842
51Legionellosis_Homo sapiens_hsa051341.10909380
52Chemical carcinogenesis_Homo sapiens_hsa052041.08136509
53Glycerolipid metabolism_Homo sapiens_hsa005611.06428780
54p53 signaling pathway_Homo sapiens_hsa041151.04861961
55Sphingolipid metabolism_Homo sapiens_hsa006001.04443821
56Linoleic acid metabolism_Homo sapiens_hsa005911.00312339
57Steroid biosynthesis_Homo sapiens_hsa001001.00291521
58Pertussis_Homo sapiens_hsa051331.00254572
59Ether lipid metabolism_Homo sapiens_hsa005650.99783956
60Renin-angiotensin system_Homo sapiens_hsa046140.98840723
61Calcium signaling pathway_Homo sapiens_hsa040200.98796618
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95663415
63Fatty acid biosynthesis_Homo sapiens_hsa000610.93196551
64Glutathione metabolism_Homo sapiens_hsa004800.92882607
65mRNA surveillance pathway_Homo sapiens_hsa030150.92765767
66Glutamatergic synapse_Homo sapiens_hsa047240.92732979
67Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92446643
68Ovarian steroidogenesis_Homo sapiens_hsa049130.89490147
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87873991
70Vitamin B6 metabolism_Homo sapiens_hsa007500.86074696
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85622413
72Malaria_Homo sapiens_hsa051440.85304756
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84909196
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82944779
75Epstein-Barr virus infection_Homo sapiens_hsa051690.82803430
76Type I diabetes mellitus_Homo sapiens_hsa049400.82144164
77Cardiac muscle contraction_Homo sapiens_hsa042600.82023183
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.81859140
79GABAergic synapse_Homo sapiens_hsa047270.80013094
80Staphylococcus aureus infection_Homo sapiens_hsa051500.78300113
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75606863
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73693170
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73101555
84Nicotine addiction_Homo sapiens_hsa050330.73077363
85Fatty acid elongation_Homo sapiens_hsa000620.70765401
86Bile secretion_Homo sapiens_hsa049760.69988624
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69322571
88Acute myeloid leukemia_Homo sapiens_hsa052210.68060832
89Metabolic pathways_Homo sapiens_hsa011000.67306234
90Circadian entrainment_Homo sapiens_hsa047130.66455393
91Fat digestion and absorption_Homo sapiens_hsa049750.65498340
92Collecting duct acid secretion_Homo sapiens_hsa049660.65187833
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.64646438
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64473677
95Autoimmune thyroid disease_Homo sapiens_hsa053200.64004790
96Systemic lupus erythematosus_Homo sapiens_hsa053220.60897903
97Sulfur relay system_Homo sapiens_hsa041220.58598604
98Toxoplasmosis_Homo sapiens_hsa051450.58281867
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57654097
100cAMP signaling pathway_Homo sapiens_hsa040240.55850605
101Asthma_Homo sapiens_hsa053100.53902714
102Osteoclast differentiation_Homo sapiens_hsa043800.51359841
103Chronic myeloid leukemia_Homo sapiens_hsa052200.50616898
104Folate biosynthesis_Homo sapiens_hsa007900.50298354
105Complement and coagulation cascades_Homo sapiens_hsa046100.48744330
106Tuberculosis_Homo sapiens_hsa051520.47479245
107Rheumatoid arthritis_Homo sapiens_hsa053230.43860244
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43369526
109Lysine degradation_Homo sapiens_hsa003100.42723754
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41313204
111Salivary secretion_Homo sapiens_hsa049700.41290329
112Fatty acid degradation_Homo sapiens_hsa000710.40307907
113Other glycan degradation_Homo sapiens_hsa005110.39777042
114Arginine and proline metabolism_Homo sapiens_hsa003300.38828851
115Allograft rejection_Homo sapiens_hsa053300.37951190
116Graft-versus-host disease_Homo sapiens_hsa053320.37567123
117PPAR signaling pathway_Homo sapiens_hsa033200.37389883
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.36978146
119Antigen processing and presentation_Homo sapiens_hsa046120.36790637
120Oocyte meiosis_Homo sapiens_hsa041140.36627732
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36199285
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36086203
123Phenylalanine metabolism_Homo sapiens_hsa003600.35223065
124Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33740766
125Serotonergic synapse_Homo sapiens_hsa047260.32352633
126Intestinal immune network for IgA production_Homo sapiens_hsa046720.32119241
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32012373
128NF-kappa B signaling pathway_Homo sapiens_hsa040640.31413787
129Vitamin digestion and absorption_Homo sapiens_hsa049770.30579448
130Taste transduction_Homo sapiens_hsa047420.30090603
131Herpes simplex infection_Homo sapiens_hsa051680.29775848
132Basal cell carcinoma_Homo sapiens_hsa052170.29737816
133Hedgehog signaling pathway_Homo sapiens_hsa043400.28968698
134Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28529224
135Retinol metabolism_Homo sapiens_hsa008300.27221167
136Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26257792
137Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24489840
138Vibrio cholerae infection_Homo sapiens_hsa051100.23052334
139Tyrosine metabolism_Homo sapiens_hsa003500.22858205
140Mineral absorption_Homo sapiens_hsa049780.21622703
141Cysteine and methionine metabolism_Homo sapiens_hsa002700.21025415
142Drug metabolism - other enzymes_Homo sapiens_hsa009830.20516054
143Hematopoietic cell lineage_Homo sapiens_hsa046400.20302509
144Primary immunodeficiency_Homo sapiens_hsa053400.18471875
145Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.18297117
146Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.17698904
147Steroid hormone biosynthesis_Homo sapiens_hsa001400.17197882
148Axon guidance_Homo sapiens_hsa043600.16972699
149NOD-like receptor signaling pathway_Homo sapiens_hsa046210.16280321
150Alcoholism_Homo sapiens_hsa050340.14536717
151Wnt signaling pathway_Homo sapiens_hsa043100.14112460
152Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.12807497
153Histidine metabolism_Homo sapiens_hsa003400.10970999
154Pentose phosphate pathway_Homo sapiens_hsa000300.10880420
155Glycerophospholipid metabolism_Homo sapiens_hsa005640.10569385
156Regulation of autophagy_Homo sapiens_hsa041400.08766697
157Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.07052618

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