ZAR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This maternal effect gene is oocyte-specific and encodes a protein that is thought to function in the initiation of embryogenesis. A similar protein in mouse is required for female fertility. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine deoxyribonucleotide catabolic process (GO:0009223)9.93319240
2pyrimidine nucleotide catabolic process (GO:0006244)8.49379441
3citrulline biosynthetic process (GO:0019240)7.75044632
4protein kinase C signaling (GO:0070528)7.57635789
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)7.55646494
6histone H2A monoubiquitination (GO:0035518)7.40236634
7protein K6-linked ubiquitination (GO:0085020)7.22535841
8regulation of meiosis (GO:0040020)7.12149607
9histone H2A ubiquitination (GO:0033522)7.09346151
10regulation of meiosis I (GO:0060631)6.97302368
11positive regulation of humoral immune response (GO:0002922)6.81797012
12female gamete generation (GO:0007292)6.71043422
13negative regulation of meiotic cell cycle (GO:0051447)6.48678405
14regulation of histone H3-K9 methylation (GO:0051570)6.28266153
15mitotic chromosome condensation (GO:0007076)6.28084108
16DNA methylation involved in gamete generation (GO:0043046)6.22152961
17pyrimidine deoxyribonucleotide metabolic process (GO:0009219)6.15899790
18negative regulation of smooth muscle cell differentiation (GO:0051151)6.11279726
19negative regulation of meiosis (GO:0045835)6.05093361
20regulation of acrosome reaction (GO:0060046)6.01746154
21retinal cone cell development (GO:0046549)5.93513854
22positive regulation of histone H3-K4 methylation (GO:0051571)5.89233505
23regulation of DNA methylation (GO:0044030)5.83940877
24regulation of exit from mitosis (GO:0007096)5.76291375
25regulation of meiotic cell cycle (GO:0051445)5.71689794
26meiotic cell cycle (GO:0051321)5.64340363
27mitotic metaphase plate congression (GO:0007080)5.42670830
28dopamine biosynthetic process (GO:0042416)5.41789968
29negative regulation of histone methylation (GO:0031061)5.30028076
30oocyte maturation (GO:0001556)5.26967066
31binding of sperm to zona pellucida (GO:0007339)5.16354187
32attachment of spindle microtubules to kinetochore (GO:0008608)5.11680807
33glycine transport (GO:0015816)5.11272429
34negative regulation of reproductive process (GO:2000242)5.05520993
35ovulation cycle (GO:0042698)4.99471496
36regulation of cell maturation (GO:1903429)4.89040038
37response to pheromone (GO:0019236)4.86976683
38chaperone-mediated protein transport (GO:0072321)4.86212581
39positive regulation of mitotic sister chromatid separation (GO:1901970)4.82444333
40positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.82444333
41positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.82444333
42citrulline metabolic process (GO:0000052)4.79040435
43multicellular organism reproduction (GO:0032504)4.74643285
44deoxyribonucleotide catabolic process (GO:0009264)4.69265488
45oocyte development (GO:0048599)4.63796233
46notochord development (GO:0030903)4.55646114
47positive regulation of gastrulation (GO:2000543)4.51226001
48regulation of histone H3-K27 methylation (GO:0061085)4.49936546
49regulation of calcium ion-dependent exocytosis (GO:0017158)4.47776596
50negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.47151318
51male meiosis (GO:0007140)4.44396442
52gene silencing by RNA (GO:0031047)4.43641477
53metaphase plate congression (GO:0051310)4.39103050
54regulation of sister chromatid cohesion (GO:0007063)4.34264356
55deoxyribose phosphate catabolic process (GO:0046386)4.32642946
56positive regulation of chromosome segregation (GO:0051984)4.29386236
57peptidyl-arginine modification (GO:0018195)4.26442215
58DNA damage induced protein phosphorylation (GO:0006975)4.23274161
59establishment of chromosome localization (GO:0051303)4.23224594
60positive regulation of reproductive process (GO:2000243)4.23181139
61regulation of steroid hormone secretion (GO:2000831)4.12086145
62microtubule severing (GO:0051013)4.09666696
63sperm-egg recognition (GO:0035036)4.06614846
64phosphorelay signal transduction system (GO:0000160)4.05986225
65positive regulation of meiosis (GO:0045836)4.05731216
66synapsis (GO:0007129)4.02359987
67primitive streak formation (GO:0090009)4.01283264
68endothelium development (GO:0003158)3.99069962
69negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.88948961
70positive regulation of histone methylation (GO:0031062)3.83722262
71positive regulation of meiotic cell cycle (GO:0051446)3.81262248
72negative regulation of DNA-templated transcription, elongation (GO:0032785)3.78448552
73negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.78448552
74phosphatidylglycerol biosynthetic process (GO:0006655)3.78201514
75centriole replication (GO:0007099)3.77639135
76CENP-A containing nucleosome assembly (GO:0034080)3.71934104
77synaptonemal complex assembly (GO:0007130)3.63652236
78fertilization (GO:0009566)3.60313635
79regulation of histone H3-K4 methylation (GO:0051569)3.60117402
80DNA alkylation (GO:0006305)3.58192951
81DNA methylation (GO:0006306)3.58192951
82establishment of spindle localization (GO:0051293)3.56529756
83protein deneddylation (GO:0000338)3.55969974
84mitotic sister chromatid segregation (GO:0000070)3.55643968
85male meiosis I (GO:0007141)3.52570905
86phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.52178513
87catechol-containing compound biosynthetic process (GO:0009713)3.52085667
88catecholamine biosynthetic process (GO:0042423)3.52085667
89regulation of steroid hormone biosynthetic process (GO:0090030)3.52010963
90reproduction (GO:0000003)3.50869591
91chromatin remodeling at centromere (GO:0031055)3.50427387
92protein localization to kinetochore (GO:0034501)3.47826555
93histone monoubiquitination (GO:0010390)3.46317268
94forebrain neuron development (GO:0021884)3.44857078
95positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.44673220
96DNA modification (GO:0006304)3.43084244
97regulation of reproductive process (GO:2000241)3.42594584
98regulation of retinoic acid receptor signaling pathway (GO:0048385)3.41975388
99chromosome organization involved in meiosis (GO:0070192)3.40479996
100phosphatidylinositol dephosphorylation (GO:0046856)3.40367405
101regulation of hypersensitivity (GO:0002883)3.38969308
102cartilage morphogenesis (GO:0060536)3.37304407
103regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.37150410
104gene silencing (GO:0016458)3.36747360
105neuron fate determination (GO:0048664)3.36303921
106regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.34748086
107protein localization to chromosome, centromeric region (GO:0071459)3.33304545
108histone exchange (GO:0043486)3.31271636
109regulation of chromatin binding (GO:0035561)3.29719592
110regulation of histone methylation (GO:0031060)3.28362439
111cell-cell recognition (GO:0009988)3.25876586
112female gonad development (GO:0008585)3.25348706
113chromosome segregation (GO:0007059)3.23728949
114L-amino acid import (GO:0043092)3.22265390
115negative regulation of execution phase of apoptosis (GO:1900118)3.21446511
116synaptonemal complex organization (GO:0070193)3.20366209
117N-terminal protein amino acid acetylation (GO:0006474)3.18573213
118establishment of spindle orientation (GO:0051294)3.16693957
119protein localization to chromosome (GO:0034502)3.16634040
120DNA replication-independent nucleosome assembly (GO:0006336)3.15209836
121DNA replication-independent nucleosome organization (GO:0034724)3.15209836
122phospholipid dephosphorylation (GO:0046839)3.14575108
123regulation of corticosteroid hormone secretion (GO:2000846)3.14488183
124regulation of chromatin silencing (GO:0031935)3.14059093
125meiotic chromosome segregation (GO:0045132)3.13535047
126labyrinthine layer development (GO:0060711)3.12668381
127negative regulation of histone modification (GO:0031057)3.11489788
128protein K11-linked ubiquitination (GO:0070979)3.09553785
129meiosis I (GO:0007127)3.08549532
130negative regulation of cAMP-mediated signaling (GO:0043951)3.08494759
131proteasome assembly (GO:0043248)3.07970919
132protein autoubiquitination (GO:0051865)3.07884333
133negative regulation of hormone biosynthetic process (GO:0032353)3.07209577
134histone ubiquitination (GO:0016574)3.04994679
135regulation of phospholipid biosynthetic process (GO:0071071)3.04960681
1362-deoxyribonucleotide metabolic process (GO:0009394)3.03568954
137protein monoubiquitination (GO:0006513)3.03352323
138meiotic nuclear division (GO:0007126)3.02868138
139translesion synthesis (GO:0019985)3.01989687
140mitotic sister chromatid cohesion (GO:0007064)3.01670916
141stress granule assembly (GO:0034063)2.99531667
142regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.99041493
143protein K48-linked ubiquitination (GO:0070936)2.98690013
144regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.98580231
145positive regulation of mitochondrial fission (GO:0090141)2.97190644
146interkinetic nuclear migration (GO:0022027)2.96904381
147DNA methylation or demethylation (GO:0044728)2.94949641
148meiotic cell cycle process (GO:1903046)2.93025688
149regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.92302611
150glycerophospholipid catabolic process (GO:0046475)2.91239556
151negative regulation of cell division (GO:0051782)2.89905861
152single fertilization (GO:0007338)2.88952604
153positive regulation of T cell apoptotic process (GO:0070234)2.88184310
154regulation of spindle organization (GO:0090224)2.82093695
155oogenesis (GO:0048477)2.81005162
156spindle checkpoint (GO:0031577)2.80756082
157regulation of female gonad development (GO:2000194)13.2887685
158piRNA metabolic process (GO:0034587)11.1358469
159base-excision repair, AP site formation (GO:0006285)10.6544766

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.10869712
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.50059536
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.34223241
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.87033320
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.83798149
6E2F7_22180533_ChIP-Seq_HELA_Human3.42435143
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.33177584
8KAP1_22055183_ChIP-Seq_ESCs_Mouse3.23086995
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.19684298
10MYC_18940864_ChIP-ChIP_HL60_Human2.96337447
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.69692618
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.69692618
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.69692618
14AR_21909140_ChIP-Seq_LNCAP_Human2.69284030
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.61035869
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.34566598
17RNF2_27304074_Chip-Seq_NSC_Mouse2.30207211
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.25845852
19MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse2.18153548
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.16710965
21GBX2_23144817_ChIP-Seq_PC3_Human2.09137085
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.05037789
23RUNX1_26923725_Chip-Seq_HPCs_Mouse1.89045784
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88563075
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.87035180
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.85952924
27GATA1_26923725_Chip-Seq_HPCs_Mouse1.83580681
28HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.79837504
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76071727
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.74797114
31GATA3_21867929_ChIP-Seq_TH1_Mouse1.74425206
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65559547
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.65333818
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61794147
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61499405
36E2F4_17652178_ChIP-ChIP_JURKAT_Human1.60804111
37NFYA_21822215_ChIP-Seq_K562_Human1.54433746
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51610182
39GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.48240651
40RBPJ_21746931_ChIP-Seq_IB4_Human1.47291929
41CBX2_22325352_ChIP-Seq_293T-Rex_Human1.41172423
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.40277753
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39582978
44ETV1_20927104_ChIP-Seq_GIST48_Human1.36816381
45SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36368817
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.35351467
47HNFA_21074721_ChIP-Seq_CACO-2_Human1.35293696
48EZH2_27294783_Chip-Seq_NPCs_Mouse1.32571946
49STAT1_17558387_ChIP-Seq_HELA_Human1.32239388
50LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32210354
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.29113709
52CDX2_22108803_ChIP-Seq_LS180_Human1.28498049
53IGF1R_20145208_ChIP-Seq_DFB_Human1.28123822
54CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27535296
55GATA6_21074721_ChIP-Seq_CACO-2_Human1.26304899
56ELK4_26923725_Chip-Seq_MESODERM_Mouse1.24244787
57RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24150784
58PHF8_20622853_ChIP-Seq_HELA_Human1.22353989
59STAT3_18555785_Chip-Seq_ESCs_Mouse1.21966493
60SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.20820797
61NANOG_21062744_ChIP-ChIP_HESCs_Human1.20447528
62TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19884326
63CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.19646262
64EP300_21415370_ChIP-Seq_HL-1_Mouse1.19584152
65CTCF_18555785_Chip-Seq_ESCs_Mouse1.17959564
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17708341
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16445045
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16388658
69ESET_19884257_ChIP-Seq_ESCs_Mouse1.16301422
70GABP_19822575_ChIP-Seq_HepG2_Human1.16156237
71TCF4_23295773_ChIP-Seq_U87_Human1.16089775
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13086416
73PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.12726892
74E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12526157
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11931869
76FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11416197
77IRF1_19129219_ChIP-ChIP_H3396_Human1.10077922
78GF1B_26923725_Chip-Seq_HPCs_Mouse1.09972210
79CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09806546
80NANOG_20526341_ChIP-Seq_ESCs_Human1.09739810
81OCT4_20526341_ChIP-Seq_ESCs_Human1.08781176
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07875009
83EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06444552
84ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05127671
85JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.05037786
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.04762633
87AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04292271
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02454724
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02422306
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02422306
91NMYC_18555785_Chip-Seq_ESCs_Mouse1.02245014
92NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.02093832
93KLF4_18555785_Chip-Seq_ESCs_Mouse1.01927983
94DROSHA_22980978_ChIP-Seq_HELA_Human1.01501861
95BP1_19119308_ChIP-ChIP_Hs578T_Human1.01335001
96ERG_20517297_ChIP-Seq_VCAP_Human1.01334845
97MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01302027
98NANOG_18555785_Chip-Seq_ESCs_Mouse1.01073255
99TBL1_22424771_ChIP-Seq_293T_Human1.01066394
100TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00909774
101NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.00769027
102VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00567305
103ESRRB_18555785_Chip-Seq_ESCs_Mouse1.00253799
104TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99620043
105IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99203457
106CBP_20019798_ChIP-Seq_JUKART_Human0.99203457
107LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98891680
108AR_25329375_ChIP-Seq_VCAP_Human0.98096589
109ZFX_18555785_Chip-Seq_ESCs_Mouse0.97060676
110REST_21632747_ChIP-Seq_MESCs_Mouse0.95830859
111CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95518921
112AR_21572438_ChIP-Seq_LNCaP_Human0.95149522
113STAT1_20625510_ChIP-Seq_HELA_Human0.94901362
114EWS_26573619_Chip-Seq_HEK293_Human0.94854760
115CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94219838
116GABP_17652178_ChIP-ChIP_JURKAT_Human0.94053707
117RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93752362
118ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93426522
119RUNX1_27457419_Chip-Seq_LIVER_Mouse0.92457843
120* SMAD4_21799915_ChIP-Seq_A2780_Human0.92300415
121GATA1_19941827_ChIP-Seq_MEL86_Mouse0.91454474
122OCT4_18555785_Chip-Seq_ESCs_Mouse0.91250466
123EZH2_22144423_ChIP-Seq_EOC_Human0.91221980
124GF1_26923725_Chip-Seq_HPCs_Mouse0.90910661
125CRX_20693478_ChIP-Seq_RETINA_Mouse0.90767748
126SOX2_18555785_Chip-Seq_ESCs_Mouse0.90576501
127RUNX2_22187159_ChIP-Seq_PCA_Human0.88707413
128JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.88305093
129ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.88268123
130STAT3_23295773_ChIP-Seq_U87_Human0.88144886
131LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87123862
132KLF4_19829295_ChIP-Seq_ESCs_Human0.86488907
133DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85588942
134NR3C1_23031785_ChIP-Seq_PC12_Mouse0.84716006
135NFYB_21822215_ChIP-Seq_K562_Human0.84578940
136P300_18555785_Chip-Seq_ESCs_Mouse0.84146732
137SMAD4_21741376_ChIP-Seq_EPCs_Human0.82459777
138TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.82191181
139CBP_21632823_ChIP-Seq_H3396_Human0.81867167
140SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.81667921
141PKCTHETA_26484144_Chip-Seq_BREAST_Human0.80918473
142VDR_22108803_ChIP-Seq_LS180_Human0.79527614
143EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.79079443
144PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.78234881
145PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76317784
146ZNF274_21170338_ChIP-Seq_K562_Hela0.75186006
147CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.75165221
148KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.75113419
149AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.73386910
150PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.73055823
151* FOXH1_21741376_ChIP-Seq_EPCs_Human0.72676853
152BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.72088489
153SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.71735937
154* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.70958021
155STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.69895788
156* EZH2_27304074_Chip-Seq_ESCs_Mouse0.68872119
157SMAD3_21741376_ChIP-Seq_EPCs_Human0.67826021
158SALL4_22934838_ChIP-ChIP_CD34+_Human0.67787531
159TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.67736005
160NANOG_18555785_ChIP-Seq_MESCs_Mouse0.67001693
161TAL1_26923725_Chip-Seq_HPCs_Mouse0.65549194
162P300_19829295_ChIP-Seq_ESCs_Human0.65283340
163SOX2_21211035_ChIP-Seq_LN229_Gbm0.65111332
164TP53_16413492_ChIP-PET_HCT116_Human0.64207675
165TP53_22573176_ChIP-Seq_HFKS_Human0.64101771
166CREB1_15753290_ChIP-ChIP_HEK293T_Human0.63280672
167KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.62030141
168* OCT4_19829295_ChIP-Seq_ESCs_Human0.60449179
169HTT_18923047_ChIP-ChIP_STHdh_Human0.60171722
170CTBP1_25329375_ChIP-Seq_LNCAP_Human0.60023488
171TAF15_26573619_Chip-Seq_HEK293_Human0.59503842
172CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.58425915
173* SMRT_27268052_Chip-Seq_Bcells_Human0.55282981
174* SMAD3_21741376_ChIP-Seq_ESCs_Human0.55149589

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue7.53031329
2* MP0003718_maternal_effect5.81016279
3MP0005451_abnormal_body_composition4.71161544
4MP0008877_abnormal_DNA_methylation4.26624613
5MP0008789_abnormal_olfactory_epithelium4.18100507
6MP0003315_abnormal_perineum_morphology3.86545354
7MP0005499_abnormal_olfactory_system3.77480799
8MP0005394_taste/olfaction_phenotype3.77480799
9MP0003693_abnormal_embryo_hatching3.64115764
10MP0005646_abnormal_pituitary_gland3.63819283
11MP0001119_abnormal_female_reproductive3.39463065
12* MP0003699_abnormal_female_reproductive3.20510753
13MP0010094_abnormal_chromosome_stability3.04746051
14MP0002139_abnormal_hepatobiliary_system2.86580769
15MP0008057_abnormal_DNA_replication2.82502355
16MP0006292_abnormal_olfactory_placode2.75306251
17MP0001929_abnormal_gametogenesis2.70801204
18MP0005187_abnormal_penis_morphology2.70629867
19MP0000579_abnormal_nail_morphology2.69244396
20MP0002138_abnormal_hepatobiliary_system2.62436657
21MP0003111_abnormal_nucleus_morphology2.53585172
22MP0004957_abnormal_blastocyst_morpholog2.50677652
23MP0003077_abnormal_cell_cycle2.49407699
24MP0000653_abnormal_sex_gland2.49379372
25MP0005257_abnormal_intraocular_pressure2.49163717
26* MP0005395_other_phenotype2.47778966
27MP0010030_abnormal_orbit_morphology2.42944402
28MP0002210_abnormal_sex_determination2.38760700
29MP0010234_abnormal_vibrissa_follicle2.30232443
30MP0002234_abnormal_pharynx_morphology2.28742055
31MP0003879_abnormal_hair_cell2.15784889
32MP0002653_abnormal_ependyma_morphology2.12196523
33MP0008260_abnormal_autophagy2.09008632
34MP0002295_abnormal_pulmonary_circulatio2.08233996
35MP0008932_abnormal_embryonic_tissue1.78917057
36MP0002102_abnormal_ear_morphology1.76255868
37MP0001529_abnormal_vocalization1.75709721
38MP0003937_abnormal_limbs/digits/tail_de1.74884313
39MP0003183_abnormal_peptide_metabolism1.68792998
40MP0003950_abnormal_plasma_membrane1.68460965
41MP0005410_abnormal_fertilization1.65721168
42* MP0002161_abnormal_fertility/fecundity1.63129191
43MP0003787_abnormal_imprinting1.63070251
44MP0010307_abnormal_tumor_latency1.61610406
45MP0000566_synostosis1.60764277
46MP0002249_abnormal_larynx_morphology1.47418830
47MP0001145_abnormal_male_reproductive1.45626951
48MP0000613_abnormal_salivary_gland1.44583207
49MP0003121_genomic_imprinting1.41818575
50MP0001905_abnormal_dopamine_level1.40017047
51MP0005408_hypopigmentation1.35172265
52MP0004859_abnormal_synaptic_plasticity1.30873869
53MP0001293_anophthalmia1.29941074
54MP0004142_abnormal_muscle_tone1.26154050
55MP0009840_abnormal_foam_cell1.25917010
56MP0010386_abnormal_urinary_bladder1.23243280
57MP0005310_abnormal_salivary_gland1.22147964
58MP0002272_abnormal_nervous_system1.20554432
59MP0002233_abnormal_nose_morphology1.19266044
60MP0000762_abnormal_tongue_morphology1.14217535
61MP0003119_abnormal_digestive_system1.08791066
62MP0001984_abnormal_olfaction1.05510963
63MP0001986_abnormal_taste_sensitivity1.04700872
64MP0002332_abnormal_exercise_endurance1.01823516
65MP0002282_abnormal_trachea_morphology0.99992405
66MP0001346_abnormal_lacrimal_gland0.98805403
67MP0005389_reproductive_system_phenotype0.96981320
68MP0000350_abnormal_cell_proliferation0.96665230
69MP0004782_abnormal_surfactant_physiolog0.96632097
70MP0001730_embryonic_growth_arrest0.95388703
71MP0010678_abnormal_skin_adnexa0.92613925
72MP0000465_gastrointestinal_hemorrhage0.92460214
73MP0002085_abnormal_embryonic_tissue0.92204915
74MP0001664_abnormal_digestion0.92107203
75MP0002019_abnormal_tumor_incidence0.91375144
76MP0002089_abnormal_postnatal_growth/wei0.90723321
77MP0003252_abnormal_bile_duct0.90202979
78MP0005360_urolithiasis0.89423819
79MP0006072_abnormal_retinal_apoptosis0.88513387
80MP0009379_abnormal_foot_pigmentation0.88072099
81MP0002932_abnormal_joint_morphology0.87240074
82MP0004264_abnormal_extraembryonic_tissu0.87229538
83MP0001919_abnormal_reproductive_system0.87208111
84MP0009384_cardiac_valve_regurgitation0.83810709
85MP0000049_abnormal_middle_ear0.81519194
86MP0003453_abnormal_keratinocyte_physiol0.80248589
87MP0000678_abnormal_parathyroid_gland0.79415127
88MP0003763_abnormal_thymus_physiology0.79343796
89MP0000427_abnormal_hair_cycle0.77674680
90MP0005551_abnormal_eye_electrophysiolog0.76440786
91MP0000639_abnormal_adrenal_gland0.76131051
92MP0009697_abnormal_copulation0.74838552
93MP0000015_abnormal_ear_pigmentation0.74587327
94MP0000490_abnormal_crypts_of0.74375399
95MP0003136_yellow_coat_color0.74126607
96MP0003942_abnormal_urinary_system0.73791311
97MP0003868_abnormal_feces_composition0.73371623
98MP0001881_abnormal_mammary_gland0.72910875
99MP0008058_abnormal_DNA_repair0.69639909
100MP0001915_intracranial_hemorrhage0.69453580
101MP0010368_abnormal_lymphatic_system0.69405870
102MP0003123_paternal_imprinting0.68487865
103MP0002796_impaired_skin_barrier0.66945120
104MP0003635_abnormal_synaptic_transmissio0.66587656
105MP0002638_abnormal_pupillary_reflex0.66555475
106MP0004510_myositis0.63567074
107MP0003698_abnormal_male_reproductive0.63313411
108MP0004185_abnormal_adipocyte_glucose0.62817941
109MP0001666_abnormal_nutrient_absorption0.62638053
110MP0003959_abnormal_lean_body0.62460718
111MP0005647_abnormal_sex_gland0.62119444
112MP0003755_abnormal_palate_morphology0.62025158
113MP0005409_darkened_coat_color0.61671463
114MP0002735_abnormal_chemical_nociception0.61529576
115MP0001672_abnormal_embryogenesis/_devel0.61067929
116MP0005380_embryogenesis_phenotype0.61067929
117MP0002090_abnormal_vision0.59531870
118MP0001324_abnormal_eye_pigmentation0.58600406
119MP0001963_abnormal_hearing_physiology0.58398227
120MP0005085_abnormal_gallbladder_physiolo0.57260922
121MP0002177_abnormal_outer_ear0.56052284
122MP0002269_muscular_atrophy0.55922912
123MP0005501_abnormal_skin_physiology0.54798722
124MP0006276_abnormal_autonomic_nervous0.53416639
125MP0001502_abnormal_circadian_rhythm0.52092009
126MP0002084_abnormal_developmental_patter0.51503660
127MP0000631_abnormal_neuroendocrine_gland0.51447942
128MP0003935_abnormal_craniofacial_develop0.51428113
129MP0004924_abnormal_behavior0.51115681
130MP0005386_behavior/neurological_phenoty0.51115681
131MP0002734_abnormal_mechanical_nocicepti0.50831428
132MP0002160_abnormal_reproductive_system0.50408659
133MP0002751_abnormal_autonomic_nervous0.48825094
134MP0009745_abnormal_behavioral_response0.48543491
135MP0004036_abnormal_muscle_relaxation0.48066839
136MP0003861_abnormal_nervous_system0.47693178
137MP0005197_abnormal_uvea_morphology0.47479616
138MP0008995_early_reproductive_senescence0.47462214
139MP0002163_abnormal_gland_morphology0.47400420
140MP0002063_abnormal_learning/memory/cond0.47005524
141MP0000428_abnormal_craniofacial_morphol0.46936524
142MP0008007_abnormal_cellular_replicative0.46923374
143MP0005621_abnormal_cell_physiology0.46836950
144MP0003984_embryonic_growth_retardation0.46337718
145MP0005220_abnormal_exocrine_pancreas0.45111919
146MP0005379_endocrine/exocrine_gland_phen0.44697910
147MP0004811_abnormal_neuron_physiology0.44141869
148MP0001697_abnormal_embryo_size0.44035586
149MP0001485_abnormal_pinna_reflex0.40994548
150MP0003890_abnormal_embryonic-extraembry0.40446143
151MP0002109_abnormal_limb_morphology0.37220200
152MP0002127_abnormal_cardiovascular_syste0.37049978
153MP0004484_altered_response_of0.36608733
154MP0002736_abnormal_nociception_after0.36227539
155MP0003880_abnormal_central_pattern0.35278883

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)9.15924107
2Cortical dysplasia (HP:0002539)6.63789684
3Infertility (HP:0000789)6.45124789
4Premature ovarian failure (HP:0008209)6.34027065
5Atelectasis (HP:0100750)5.71768024
6Birth length less than 3rd percentile (HP:0003561)5.16524158
7Breast hypoplasia (HP:0003187)5.15122962
8Hypokinesia (HP:0002375)4.88578646
9Osteomalacia (HP:0002749)4.76910296
10Abdominal situs inversus (HP:0003363)4.72708305
11Abnormality of abdominal situs (HP:0011620)4.72708305
12Secondary amenorrhea (HP:0000869)4.60216395
13Oligodactyly (hands) (HP:0001180)4.56029385
14Anosmia (HP:0000458)4.55968883
15Limb dystonia (HP:0002451)4.44856724
16Chromsome breakage (HP:0040012)4.33938001
17Facial hemangioma (HP:0000329)4.26147586
18Impulsivity (HP:0100710)4.25187184
19Chromosomal breakage induced by crosslinking agents (HP:0003221)4.18134976
20Lip pit (HP:0100267)4.17148986
21Septo-optic dysplasia (HP:0100842)3.90955315
22Hypophosphatemic rickets (HP:0004912)3.82484017
23Hypergonadotropic hypogonadism (HP:0000815)3.79762815
24Pulmonary fibrosis (HP:0002206)3.77836496
25Aplasia/Hypoplasia of the breasts (HP:0010311)3.76962100
26Abnormal gallbladder physiology (HP:0012438)3.75154804
27Cholecystitis (HP:0001082)3.75154804
28Breast aplasia (HP:0100783)3.69202919
29Abnormality of the fovea (HP:0000493)3.68203157
30Flat capital femoral epiphysis (HP:0003370)3.61368588
31Hypogonadotrophic hypogonadism (HP:0000044)3.49540684
32Aplasia/Hypoplasia of the fovea (HP:0008060)3.49302167
33Hypoplasia of the fovea (HP:0007750)3.49302167
34Patellar aplasia (HP:0006443)3.46178081
35Adrenal hypoplasia (HP:0000835)3.42307034
36Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.39790699
37Myokymia (HP:0002411)3.36857688
38Azoospermia (HP:0000027)3.26434121
39Oligodactyly (HP:0012165)3.25207689
40Absent septum pellucidum (HP:0001331)3.21195650
41Aplasia/Hypoplasia of the patella (HP:0006498)3.14583716
42Median cleft lip (HP:0000161)3.04814785
43Abnormality of the labia minora (HP:0012880)3.04488711
44Abnormality of alanine metabolism (HP:0010916)3.04363574
45Hyperalaninemia (HP:0003348)3.04363574
46Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.04363574
47Insulin-resistant diabetes mellitus (HP:0000831)3.03869315
48Deep venous thrombosis (HP:0002625)3.03763455
49Enlarged penis (HP:0000040)3.01846038
50Apathy (HP:0000741)3.00367496
51Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.99654818
52Gonadotropin excess (HP:0000837)2.93912849
53Diminished motivation (HP:0000745)2.91133409
54Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.90092579
55Shawl scrotum (HP:0000049)2.88710210
56Primary amenorrhea (HP:0000786)2.86351080
57Rhabdomyosarcoma (HP:0002859)2.82139273
58Truncal obesity (HP:0001956)2.73406016
59Capillary hemangiomas (HP:0005306)2.72925957
60Nonprogressive disorder (HP:0003680)2.72092414
61Amniotic constriction ring (HP:0009775)2.69970655
62Abnormality of placental membranes (HP:0011409)2.69970655
63Oral leukoplakia (HP:0002745)2.69164920
64Abnormality of the septum pellucidum (HP:0007375)2.66536269
65Short tibia (HP:0005736)2.66511924
66Aplastic anemia (HP:0001915)2.62737605
67Lower limb hyperreflexia (HP:0002395)2.62381353
68Bronchiectasis (HP:0002110)2.61932183
69Supranuclear gaze palsy (HP:0000605)2.58011912
70Fibular aplasia (HP:0002990)2.56469140
71Thyroid carcinoma (HP:0002890)2.56110146
72Papilledema (HP:0001085)2.53097307
73Diminished movement (HP:0002374)2.49271122
74Wrist flexion contracture (HP:0001239)2.48746153
75Proximal tubulopathy (HP:0000114)2.44606199
76Urethral obstruction (HP:0000796)2.41403779
77Fair hair (HP:0002286)2.41177533
78Aplasia/Hypoplasia involving the musculature (HP:0001460)2.40873536
79Delayed puberty (HP:0000823)2.40565532
80Combined immunodeficiency (HP:0005387)2.40302523
81Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.39307741
82Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.39118433
83Supernumerary spleens (HP:0009799)2.38977958
84Aplasia involving forearm bones (HP:0009822)2.35514646
85Absent forearm bone (HP:0003953)2.35514646
86Abnormal spermatogenesis (HP:0008669)2.35057325
87Absent hand (HP:0004050)2.35030235
88Aplasia/Hypoplasia of the tibia (HP:0005772)2.34613319
89Aplasia of the musculature (HP:0100854)2.32654435
90Spinal cord compression (HP:0002176)2.31879811
91Papillary thyroid carcinoma (HP:0002895)2.29356043
92Overlapping toe (HP:0001845)2.28151110
93Abnormality of cochlea (HP:0000375)2.28047500
94Abnormal biliary tract physiology (HP:0012439)2.25510988
95Bile duct proliferation (HP:0001408)2.25510988
96Absent radius (HP:0003974)2.25103385
97Loss of speech (HP:0002371)2.24158712
98Conjunctival telangiectasia (HP:0000524)2.20222132
99Anterior segment dysgenesis (HP:0007700)2.19818195
100Fetal akinesia sequence (HP:0001989)2.19297084
101Aplasia/Hypoplasia of the uvula (HP:0010293)2.14965090
102Aplasia/Hypoplasia of the macula (HP:0008059)2.14421276
103Abnormality of aromatic amino acid family metabolism (HP:0004338)2.12375596
104Generalized aminoaciduria (HP:0002909)2.11631509
105Striae distensae (HP:0001065)2.10983235
106Sloping forehead (HP:0000340)2.09844831
107Skin pits (HP:0100276)2.09433776
108Muscle stiffness (HP:0003552)2.09261506
109Duodenal stenosis (HP:0100867)2.08751073
110Small intestinal stenosis (HP:0012848)2.08751073
111Stillbirth (HP:0003826)2.07439061
112Abnormality of the preputium (HP:0100587)2.06905546
113Metaphyseal irregularity (HP:0003025)2.06058344
114Abnormality of chromosome segregation (HP:0002916)2.05215616
115Abnormality of chromosome stability (HP:0003220)2.04195818
116Maternal diabetes (HP:0009800)2.03714034
117Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.02790778
118Dysdiadochokinesis (HP:0002075)2.01152260
119Anhidrosis (HP:0000970)2.01024513
120Abnormality of calcium-phosphate metabolism (HP:0100530)2.00660803
121Hypercortisolism (HP:0001578)2.00563275
122Chronic bronchitis (HP:0004469)2.00538961
123Aplasia/Hypoplasia of the sternum (HP:0006714)1.98130735
124Arterial tortuosity (HP:0005116)1.96056874
125Nephroblastoma (Wilms tumor) (HP:0002667)1.95581061
126Cone-rod dystrophy (HP:0000548)1.95221982
127Abnormal lung lobation (HP:0002101)1.89527788
128Neoplasm of striated muscle (HP:0009728)1.88852372
129Bundle branch block (HP:0011710)1.88209606
130Meckel diverticulum (HP:0002245)1.87794529
131Bradykinesia (HP:0002067)1.86665491
132Aplasia/Hypoplasia of the tongue (HP:0010295)1.86092238
133Aplasia/Hypoplasia affecting the retina (HP:0008061)1.85023338
134Abnormality of the anterior chamber (HP:0000593)1.85016150
135Carpal bone hypoplasia (HP:0001498)1.83950672
136Erectile abnormalities (HP:0100639)1.83378961
137Embryonal renal neoplasm (HP:0011794)1.82164049
138Malnutrition (HP:0004395)1.81796703
139Hypoplastic iliac wings (HP:0002866)1.80791203
140Gaze-evoked nystagmus (HP:0000640)1.78870357
141Abnormality of midbrain morphology (HP:0002418)1.78822791
142Molar tooth sign on MRI (HP:0002419)1.78822791
143Anomalous pulmonary venous return (HP:0010772)1.77679049
144Congenital sensorineural hearing impairment (HP:0008527)1.77587726
145Abnormality of the proximal phalanges of the hand (HP:0009834)1.77445799
146Limb hypertonia (HP:0002509)1.77293588
147Heterotopia (HP:0002282)1.75129487
148Dysmetric saccades (HP:0000641)1.74853555
149Duplicated collecting system (HP:0000081)1.73711934
150Shallow orbits (HP:0000586)1.73400104
151Abnormality of the labia (HP:0000058)1.72918987
152Sensory axonal neuropathy (HP:0003390)1.72347399
153Aplasia involving bones of the extremities (HP:0009825)1.72288040
154Aplasia involving bones of the upper limbs (HP:0009823)1.72288040
155Aplasia of the phalanges of the hand (HP:0009802)1.72288040
156Hip contracture (HP:0003273)1.72191916
157Bicornuate uterus (HP:0000813)1.71886122
158Increased circulating renin level (HP:0000848)1.71629749
159Abnormality of the renal collecting system (HP:0004742)1.71204578
160Ankle contracture (HP:0006466)1.70817997
161Chorioretinal atrophy (HP:0000533)1.70127700
162Abnormality of the ileum (HP:0001549)1.69504460
163Intrahepatic cholestasis (HP:0001406)1.68493284
164Posterior embryotoxon (HP:0000627)1.67915936
165Abnormal sex determination (HP:0012244)1.65749831
166Sex reversal (HP:0012245)1.65749831
167Hypoplastic pelvis (HP:0008839)1.64729173
168Vascular tortuosity (HP:0004948)1.64098723
169Abnormality of the phalanges of the hallux (HP:0010057)1.62818623
170Occipital encephalocele (HP:0002085)1.62248667
171Short thumb (HP:0009778)1.61762833
172Abnormality of the epiphysis of the femoral head (HP:0010574)1.60805941
173Rib fusion (HP:0000902)1.60399117
174Ectopic kidney (HP:0000086)1.58919438

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR27.41408977
2MOS6.53568360
3TAOK35.00807083
4MAP3K64.60778184
5ERBB43.34328468
6CDK123.26783511
7LATS22.93582867
8NEK62.78665569
9LATS12.72796978
10TTK2.68380472
11KSR22.54634011
12PRKD32.54454864
13MET2.21222382
14PLK42.18910975
15CDK82.13591154
16STK38L2.04950131
17MAP3K91.86468482
18BUB11.85000086
19STK101.76176351
20BRAF1.66862179
21MAP3K131.62248482
22MELK1.57333881
23DYRK21.56499820
24ARAF1.43728082
25TRIM281.39629595
26PRKCI1.37260817
27CDC71.34546375
28MAPK131.33449229
29CAMK1D1.27590037
30CHEK21.25869184
31PLK11.19816684
32TAOK11.19251677
33BRSK11.10695693
34MAP2K71.10301495
35STK31.09430357
36EIF2AK31.09007380
37MAP3K81.07561463
38EEF2K1.07262179
39MUSK1.07176371
40WNK11.05175900
41ZAK1.03454133
42NLK1.03447276
43NEK21.01672038
44CSNK1G11.00635146
45MAP3K40.98844897
46TNIK0.98379539
47CDK90.96605007
48CAMK1G0.93828287
49NTRK30.90194297
50STK390.89242506
51AURKA0.89094080
52PRKD20.82005559
53BRD40.80982249
54PIM10.80490188
55PINK10.80378406
56NME10.79836341
57PTK20.79733865
58CSNK1G30.78944247
59RAF10.77640681
60MST40.75696213
61TIE10.74227883
62ABL20.73377400
63MAPKAPK50.68735532
64MAPKAPK30.68713954
65NUAK10.66269361
66CSNK1G20.64640380
67RET0.64162511
68MTOR0.62830845
69AURKB0.61956001
70CSNK1A1L0.59163645
71TNK20.58587872
72ACVR1B0.58474072
73PRKCZ0.57131124
74MAP3K20.53322646
75STK240.53181436
76CDK190.51187589
77PRKG10.51133373
78CDK50.50259953
79LRRK20.50000546
80PAK60.48115202
81MAP2K20.47219622
82CSNK1E0.47070248
83PLK30.46881576
84MAP3K10.46875567
85TGFBR10.46606131
86MARK30.45279788
87STK380.43811847
88KSR10.43549261
89PKN10.42704260
90NEK90.42090152
91HIPK20.40942439
92VRK10.40210796
93CDK150.39863045
94SGK2230.39792422
95SGK4940.39792422
96CDK11A0.39724672
97MAP2K40.39524707
98EPHA40.39247417
99DMPK0.34280033
100CDK180.34146932
101SGK20.34028790
102PRKACB0.33695325
103CDK40.32891350
104GSK3B0.32839707
105EIF2AK10.31221457
106BRSK20.30592586
107CAMK2D0.29759929
108PRKACA0.29085187
109MAPK100.27582567
110DYRK30.27297476
111PRKAA10.26980042
112FLT30.26966186
113AKT20.26283575
114NTRK20.26043853
115TYRO30.25728155
116MAPK110.25117833
117CAMK40.24988276
118PLK20.24689259
119CDK140.24671898
120CDK70.24631345
121ATM0.22044905
122GRK50.21981940
123ABL10.21349181
124ICK0.21234181
125OXSR10.21144492
126MAP3K70.21068886
127CAMK2A0.21058243
128CDK10.20502275
129MAP2K10.17630813
130CSNK1D0.15404575
131CHEK10.14733847
132MAP3K50.14534048
133ATR0.13924739
134CSNK1A10.13768632
135CDK20.11417287
136ADRBK10.09057308
137BMPR1B0.08238961
138PAK10.07897917
139AKT10.07772954
140KIT0.04350225
141TRPM70.03501182
142PRKAA20.02953163
143ROCK10.02566961
144STK110.02282597
145EIF2AK20.00133703
146MAPK1-0.0104606
147RPS6KB2-0.0032577
148RPS6KA1-0.0028148
149PRKCH-0.0028022
150CHUK-0.0015889

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049135.41225438
2Basal transcription factors_Homo sapiens_hsa030224.08486343
3RNA degradation_Homo sapiens_hsa030183.33380930
4Cell cycle_Homo sapiens_hsa041103.31945441
5Oocyte meiosis_Homo sapiens_hsa041143.01771944
6Vitamin B6 metabolism_Homo sapiens_hsa007502.87261123
7Fanconi anemia pathway_Homo sapiens_hsa034602.62736516
8RNA polymerase_Homo sapiens_hsa030202.44186626
9Linoleic acid metabolism_Homo sapiens_hsa005912.42402232
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.41511044
11Homologous recombination_Homo sapiens_hsa034402.37515082
12Base excision repair_Homo sapiens_hsa034102.37098526
13Circadian rhythm_Homo sapiens_hsa047102.35826539
14Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.35814043
15Caffeine metabolism_Homo sapiens_hsa002322.33339830
16Ether lipid metabolism_Homo sapiens_hsa005652.25661133
17GnRH signaling pathway_Homo sapiens_hsa049122.11256089
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.10718173
19Dorso-ventral axis formation_Homo sapiens_hsa043202.10550980
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.08473898
21RNA transport_Homo sapiens_hsa030132.05975659
22Olfactory transduction_Homo sapiens_hsa047401.86397652
23DNA replication_Homo sapiens_hsa030301.79925502
24Pancreatic cancer_Homo sapiens_hsa052121.65893319
25Non-homologous end-joining_Homo sapiens_hsa034501.65179213
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.56877666
27Synaptic vesicle cycle_Homo sapiens_hsa047211.49715743
28mRNA surveillance pathway_Homo sapiens_hsa030151.44901323
29Nicotine addiction_Homo sapiens_hsa050331.40993410
30Nucleotide excision repair_Homo sapiens_hsa034201.40733615
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.36052201
32Mismatch repair_Homo sapiens_hsa034301.30298084
33Cocaine addiction_Homo sapiens_hsa050301.26572674
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25822021
35Glycerophospholipid metabolism_Homo sapiens_hsa005641.19184892
36Folate biosynthesis_Homo sapiens_hsa007901.15956513
37TGF-beta signaling pathway_Homo sapiens_hsa043501.11757073
38Long-term depression_Homo sapiens_hsa047301.11747211
39MicroRNAs in cancer_Homo sapiens_hsa052061.10208770
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.07712089
41GABAergic synapse_Homo sapiens_hsa047271.02020681
42Colorectal cancer_Homo sapiens_hsa052101.01162500
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00510234
44Morphine addiction_Homo sapiens_hsa050321.00083723
45Pyrimidine metabolism_Homo sapiens_hsa002400.97815760
46Amphetamine addiction_Homo sapiens_hsa050310.94468766
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94150049
48ABC transporters_Homo sapiens_hsa020100.92057221
49Phototransduction_Homo sapiens_hsa047440.88128404
50Choline metabolism in cancer_Homo sapiens_hsa052310.87652741
51Purine metabolism_Homo sapiens_hsa002300.85941586
52Sphingolipid metabolism_Homo sapiens_hsa006000.84779896
53Bladder cancer_Homo sapiens_hsa052190.83776651
54Prolactin signaling pathway_Homo sapiens_hsa049170.81845010
55Other glycan degradation_Homo sapiens_hsa005110.80056343
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79419989
57mTOR signaling pathway_Homo sapiens_hsa041500.75323135
58p53 signaling pathway_Homo sapiens_hsa041150.75241279
59Bile secretion_Homo sapiens_hsa049760.74823102
60Taste transduction_Homo sapiens_hsa047420.74409696
61VEGF signaling pathway_Homo sapiens_hsa043700.74393274
62Arachidonic acid metabolism_Homo sapiens_hsa005900.73247314
63Regulation of autophagy_Homo sapiens_hsa041400.70878571
64Dopaminergic synapse_Homo sapiens_hsa047280.70333471
65Ras signaling pathway_Homo sapiens_hsa040140.69251561
66Inositol phosphate metabolism_Homo sapiens_hsa005620.67093609
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65881708
68Serotonergic synapse_Homo sapiens_hsa047260.61175023
69Hippo signaling pathway_Homo sapiens_hsa043900.57046259
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56679796
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55185776
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53329256
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51213730
74Notch signaling pathway_Homo sapiens_hsa043300.50212211
75Protein export_Homo sapiens_hsa030600.48309498
76Viral carcinogenesis_Homo sapiens_hsa052030.48113346
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47739139
78Histidine metabolism_Homo sapiens_hsa003400.45619890
79Glutamatergic synapse_Homo sapiens_hsa047240.43693343
80Melanoma_Homo sapiens_hsa052180.43434163
81Renal cell carcinoma_Homo sapiens_hsa052110.42556466
82ErbB signaling pathway_Homo sapiens_hsa040120.42083257
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42038321
84beta-Alanine metabolism_Homo sapiens_hsa004100.41965773
85Vitamin digestion and absorption_Homo sapiens_hsa049770.41654124
86Collecting duct acid secretion_Homo sapiens_hsa049660.41599219
87Gap junction_Homo sapiens_hsa045400.41245471
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.39899589
89MAPK signaling pathway_Homo sapiens_hsa040100.39782549
90Fatty acid elongation_Homo sapiens_hsa000620.39080601
91Thyroid cancer_Homo sapiens_hsa052160.38992686
92HTLV-I infection_Homo sapiens_hsa051660.38424100
93Shigellosis_Homo sapiens_hsa051310.38423259
94Circadian entrainment_Homo sapiens_hsa047130.36692571
95Huntingtons disease_Homo sapiens_hsa050160.35351907
96Cholinergic synapse_Homo sapiens_hsa047250.34707303
97FoxO signaling pathway_Homo sapiens_hsa040680.34530657
98Arginine and proline metabolism_Homo sapiens_hsa003300.34253924
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33917394
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33836308
101Oxytocin signaling pathway_Homo sapiens_hsa049210.32675749
102Peroxisome_Homo sapiens_hsa041460.32539188
103Insulin secretion_Homo sapiens_hsa049110.32512757
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31828161
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31481968
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30390179
107Non-small cell lung cancer_Homo sapiens_hsa052230.29363754
108Adherens junction_Homo sapiens_hsa045200.29064900
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28541513
110cAMP signaling pathway_Homo sapiens_hsa040240.27416969
111Long-term potentiation_Homo sapiens_hsa047200.27146553
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25943651
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.23645922
114Proteasome_Homo sapiens_hsa030500.22961507
115Lysine degradation_Homo sapiens_hsa003100.22417055
116Phagosome_Homo sapiens_hsa041450.21310237
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.20889684
118Estrogen signaling pathway_Homo sapiens_hsa049150.20777098
119Alcoholism_Homo sapiens_hsa050340.20472516
120Endometrial cancer_Homo sapiens_hsa052130.19732251
121Chronic myeloid leukemia_Homo sapiens_hsa052200.19095493
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18936777
123Propanoate metabolism_Homo sapiens_hsa006400.18846082
124Small cell lung cancer_Homo sapiens_hsa052220.18501084
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.17624637
126Herpes simplex infection_Homo sapiens_hsa051680.16734432
127Wnt signaling pathway_Homo sapiens_hsa043100.16388020
128Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.15942127
129Hepatitis B_Homo sapiens_hsa051610.15310308
130Apoptosis_Homo sapiens_hsa042100.14675237
131cGMP-PKG signaling pathway_Homo sapiens_hsa040220.14612848
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.14320039
133Malaria_Homo sapiens_hsa051440.12944816
134Glioma_Homo sapiens_hsa052140.10965665
135Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.09170783
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.08821935
137Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.08571431
138Retinol metabolism_Homo sapiens_hsa008300.08374104

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