ZAR1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ZAR1 family that is predominantly expressed in oocytes and early embryos. The protein may function as an RNA regulator in early embryos. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1base-excision repair, AP site formation (GO:0006285)8.90671717
2citrulline biosynthetic process (GO:0019240)8.71859149
3pyrimidine deoxyribonucleotide catabolic process (GO:0009223)8.42709162
4regulation of acrosome reaction (GO:0060046)7.85235007
5histone H2A monoubiquitination (GO:0035518)7.45929752
6histone H2A ubiquitination (GO:0033522)7.24052326
7pyrimidine nucleotide catabolic process (GO:0006244)7.12130180
8DNA methylation involved in gamete generation (GO:0043046)6.93121360
9regulation of histone H3-K9 methylation (GO:0051570)6.77549359
10protein K6-linked ubiquitination (GO:0085020)6.63942793
11positive regulation of histone H3-K4 methylation (GO:0051571)6.63366204
12regulation of exit from mitosis (GO:0007096)6.59674348
13mitotic chromosome condensation (GO:0007076)6.04897410
14mitotic metaphase plate congression (GO:0007080)6.04672097
15regulation of meiosis (GO:0040020)6.02889910
16female gamete generation (GO:0007292)5.99220406
17negative regulation of smooth muscle cell differentiation (GO:0051151)5.95738728
18multicellular organism reproduction (GO:0032504)5.91081648
19retinal cone cell development (GO:0046549)5.87839437
20negative regulation of histone methylation (GO:0031061)5.73303008
21regulation of steroid hormone secretion (GO:2000831)5.68063951
22oocyte maturation (GO:0001556)5.45388625
23ovulation cycle (GO:0042698)5.42692639
24oocyte development (GO:0048599)5.31656438
25negative regulation of reproductive process (GO:2000242)5.30985354
26citrulline metabolic process (GO:0000052)5.26399187
27negative regulation of meiosis (GO:0045835)5.24990719
28negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.13837202
29positive regulation of reproductive process (GO:2000243)5.10619444
30sperm-egg recognition (GO:0035036)5.02444221
31peptidyl-arginine modification (GO:0018195)5.01650899
32regulation of sister chromatid cohesion (GO:0007063)4.98284119
33pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.95842359
34male meiosis (GO:0007140)4.94815235
35microtubule severing (GO:0051013)4.85687463
36metaphase plate congression (GO:0051310)4.84093868
37chaperone-mediated protein transport (GO:0072321)4.77624538
38regulation of meiotic cell cycle (GO:0051445)4.75036341
39glycine transport (GO:0015816)4.73781648
40gene silencing by RNA (GO:0031047)4.71613254
41notochord development (GO:0030903)4.69578830
42meiotic cell cycle (GO:0051321)4.62782258
43attachment of spindle microtubules to kinetochore (GO:0008608)4.62064124
44establishment of chromosome localization (GO:0051303)4.60012658
45reproduction (GO:0000003)4.40538991
46regulation of cell maturation (GO:1903429)4.39632097
47regulation of hypersensitivity (GO:0002883)4.30942575
48positive regulation of meiosis (GO:0045836)4.27081640
49positive regulation of mitotic sister chromatid separation (GO:1901970)4.23235132
50positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.23235132
51positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.23235132
52positive regulation of histone methylation (GO:0031062)4.18135404
53positive regulation of gastrulation (GO:2000543)4.16087325
54regulation of steroid hormone biosynthetic process (GO:0090030)4.15556712
55regulation of histone H3-K4 methylation (GO:0051569)4.11570590
56cell-cell recognition (GO:0009988)4.06599224
57negative regulation of meiotic cell cycle (GO:0051447)4.04413473
58DNA damage induced protein phosphorylation (GO:0006975)4.04380340
59positive regulation of meiotic cell cycle (GO:0051446)4.03753160
60fertilization (GO:0009566)4.02254374
61mitotic sister chromatid segregation (GO:0000070)4.01679501
62cartilage morphogenesis (GO:0060536)3.98403815
63DNA methylation (GO:0006306)3.94214716
64DNA alkylation (GO:0006305)3.94214716
65regulation of retinoic acid receptor signaling pathway (GO:0048385)3.94123397
66regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.89799558
67interkinetic nuclear migration (GO:0022027)3.79764679
68phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.79296253
69regulation of phospholipid biosynthetic process (GO:0071071)3.78736408
70primitive streak formation (GO:0090009)3.76236305
71protein localization to kinetochore (GO:0034501)3.68249094
72response to pheromone (GO:0019236)3.65477724
73mitotic sister chromatid cohesion (GO:0007064)3.64603808
74regulation of DNA methylation (GO:0044030)3.64174500
75regulation of histone methylation (GO:0031060)3.61445238
76stress granule assembly (GO:0034063)3.59258262
77phosphatidylglycerol biosynthetic process (GO:0006655)3.59018781
78deoxyribonucleotide catabolic process (GO:0009264)3.56096403
79regulation of chromatin silencing (GO:0031935)3.54536293
80N-terminal protein amino acid acetylation (GO:0006474)3.52460829
81protein localization to chromosome, centromeric region (GO:0071459)3.52198381
82positive regulation of humoral immune response (GO:0002922)3.51839075
83histone monoubiquitination (GO:0010390)3.48563196
84single fertilization (GO:0007338)3.47061385
85phosphatidylinositol dephosphorylation (GO:0046856)3.46670550
86negative regulation of histone modification (GO:0031057)3.45353388
87negative regulation of DNA-templated transcription, elongation (GO:0032785)3.43341012
88negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.43341012
89synapsis (GO:0007129)3.41832589
90regulation of calcium ion-dependent exocytosis (GO:0017158)3.41668080
91regulation of spindle organization (GO:0090224)3.41640884
92synaptonemal complex assembly (GO:0007130)3.40824037
93phosphorelay signal transduction system (GO:0000160)3.40823918
94oogenesis (GO:0048477)3.40193922
95regulation of meiosis I (GO:0060631)3.39477462
96endothelium development (GO:0003158)3.39176944
97type B pancreatic cell development (GO:0003323)3.38780740
98gene silencing (GO:0016458)3.38766903
99protein deneddylation (GO:0000338)3.36244806
100chromosome segregation (GO:0007059)3.35472994
101female gonad development (GO:0008585)3.35414061
102meiotic chromosome segregation (GO:0045132)3.34690119
103regulation of chromatin binding (GO:0035561)3.34373139
104DNA modification (GO:0006304)3.34126706
105forebrain neuron development (GO:0021884)3.33838603
106histone H3-K9 demethylation (GO:0033169)3.33808649
107synaptonemal complex organization (GO:0070193)3.31235265
108positive regulation of hormone biosynthetic process (GO:0046886)3.29150006
109histone ubiquitination (GO:0016574)3.28800489
110deoxyribose phosphate catabolic process (GO:0046386)3.28349720
111negative regulation of hormone biosynthetic process (GO:0032353)3.27628390
112protein kinase C signaling (GO:0070528)3.27582548
113sphingosine metabolic process (GO:0006670)3.25036593
114positive regulation of interleukin-4 production (GO:0032753)3.23393025
115positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.23100209
116centriole replication (GO:0007099)3.22572848
117protein localization to chromosome (GO:0034502)3.21876962
118regulation of histone H3-K27 methylation (GO:0061085)3.21232419
119regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.21176032
120phospholipid dephosphorylation (GO:0046839)3.21094756
121positive regulation of uterine smooth muscle contraction (GO:0070474)3.19312937
122regulation of reproductive process (GO:2000241)3.17651680
123sister chromatid segregation (GO:0000819)3.17510044
124CENP-A containing nucleosome assembly (GO:0034080)3.16977390
125male meiosis I (GO:0007141)3.16214375
126regulation of corticosteroid hormone secretion (GO:2000846)3.15389644
127regulation of G2/M transition of mitotic cell cycle (GO:0010389)3.14313509
128protein K11-linked ubiquitination (GO:0070979)3.13247363
129L-amino acid import (GO:0043092)3.12429182
130positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.12382793
131DNA replication checkpoint (GO:0000076)3.11848519
132binding of sperm to zona pellucida (GO:0007339)3.10907145
133positive regulation of chromosome segregation (GO:0051984)3.10800318
134negative regulation of hormone metabolic process (GO:0032351)3.09304367
135negative regulation of chromatin modification (GO:1903309)3.06085931
136DNA methylation or demethylation (GO:0044728)3.06038258
137protein monoubiquitination (GO:0006513)3.06020451
138histone exchange (GO:0043486)3.04945620
139regulation of chromosome segregation (GO:0051983)3.03919063
140DNA replication-dependent nucleosome assembly (GO:0006335)3.03135710
141DNA replication-dependent nucleosome organization (GO:0034723)3.03135710
142positive regulation of DNA-dependent DNA replication (GO:2000105)3.01338287
143resolution of meiotic recombination intermediates (GO:0000712)2.99051965
144chromosome organization involved in meiosis (GO:0070192)2.98922085
145regulation of mitotic spindle organization (GO:0060236)2.96781818
146fat-soluble vitamin biosynthetic process (GO:0042362)2.96062846
147histone H3-K4 methylation (GO:0051568)2.94855670
148glycerophospholipid catabolic process (GO:0046475)2.94728953
149protein autoubiquitination (GO:0051865)2.94255007
150regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.94099883
151histone H3-K4 trimethylation (GO:0080182)2.92905146
152positive regulation of endothelial cell differentiation (GO:0045603)2.92241102
153regulation of cell cycle G2/M phase transition (GO:1902749)2.90370608
154positive regulation of gene expression, epigenetic (GO:0045815)2.88549076
155positive regulation of steroid hormone secretion (GO:2000833)2.87619282
156regulation of female gonad development (GO:2000194)12.0722357
157piRNA metabolic process (GO:0034587)11.9067084

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.35277409
2FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.17466550
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.93196021
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.87161842
5KAP1_22055183_ChIP-Seq_ESCs_Mouse3.53429679
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.38202824
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.24711581
8AR_21909140_ChIP-Seq_LNCAP_Human2.89341592
9E2F7_22180533_ChIP-Seq_HELA_Human2.81925222
10MYC_18940864_ChIP-ChIP_HL60_Human2.44773781
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.30482760
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.21712879
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.21712879
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.21712879
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.21486813
16RNF2_27304074_Chip-Seq_NSC_Mouse2.18018822
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.13923744
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.11196097
19MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse2.04106574
20EZH2_22144423_ChIP-Seq_EOC_Human1.95590269
21TP63_19390658_ChIP-ChIP_HaCaT_Human1.92093180
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.86945483
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.81605918
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.70876926
25E2F4_17652178_ChIP-ChIP_JURKAT_Human1.66105256
26GATA3_21867929_ChIP-Seq_TH1_Mouse1.65471472
27GATA1_26923725_Chip-Seq_HPCs_Mouse1.64540196
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63630194
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61824935
30IGF1R_20145208_ChIP-Seq_DFB_Human1.59122438
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.58604619
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54263627
33NFYA_21822215_ChIP-Seq_K562_Human1.52661988
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.47430232
35RUNX1_26923725_Chip-Seq_HPCs_Mouse1.47385649
36SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44078318
37STAT1_17558387_ChIP-Seq_HELA_Human1.42751477
38CBX2_22325352_ChIP-Seq_293T-Rex_Human1.39954796
39LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39442552
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39370555
41RBPJ_21746931_ChIP-Seq_IB4_Human1.38379154
42GBX2_23144817_ChIP-Seq_PC3_Human1.37819166
43ETV1_20927104_ChIP-Seq_GIST48_Human1.36819795
44NANOG_21062744_ChIP-ChIP_HESCs_Human1.36387481
45GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.36101277
46KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.35749934
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.34568380
48HNFA_21074721_ChIP-Seq_CACO-2_Human1.33224912
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33173236
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32055291
51TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.31399433
52EP300_21415370_ChIP-Seq_HL-1_Mouse1.27871114
53AUTS2_25519132_ChIP-Seq_293T-REX_Human1.27234675
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.24536460
55ESET_19884257_ChIP-Seq_ESCs_Mouse1.22328814
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.18286772
57STAT3_18555785_Chip-Seq_ESCs_Mouse1.17720864
58GATA6_21074721_ChIP-Seq_CACO-2_Human1.17653384
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17170140
60PHF8_20622853_ChIP-Seq_HELA_Human1.17099886
61CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.15636002
62TBL1_22424771_ChIP-Seq_293T_Human1.14761026
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14563469
64ELK4_26923725_Chip-Seq_MESODERM_Mouse1.11166688
65KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10979430
66* CDX2_22108803_ChIP-Seq_LS180_Human1.10170343
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10005904
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09956434
69FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09714898
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09443475
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.09366363
72CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.09203751
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.09182131
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08999078
75CTCF_18555785_Chip-Seq_ESCs_Mouse1.08429765
76STAT3_23295773_ChIP-Seq_U87_Human1.07512819
77FOXH1_21741376_ChIP-Seq_EPCs_Human1.05919169
78SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.05700769
79OCT4_20526341_ChIP-Seq_ESCs_Human1.03402699
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03342285
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02300294
82CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02265357
83TCF4_23295773_ChIP-Seq_U87_Human1.01872875
84GABP_19822575_ChIP-Seq_HepG2_Human1.01758794
85GATA1_19941827_ChIP-Seq_MEL86_Mouse1.01356761
86PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.01302544
87NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.00851316
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00280335
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00280335
90SMAD4_21741376_ChIP-Seq_EPCs_Human1.00096775
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99724636
92GATA3_26560356_Chip-Seq_TH1_Human0.98760610
93VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98214768
94BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97876988
95STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97645071
96EWS_26573619_Chip-Seq_HEK293_Human0.96829065
97SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96621356
98TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96583493
99GF1B_26923725_Chip-Seq_HPCs_Mouse0.96266525
100KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.95763367
101ZFX_18555785_Chip-Seq_ESCs_Mouse0.95108526
102KDM2B_26808549_Chip-Seq_REH_Human0.94913093
103GF1_26923725_Chip-Seq_HPCs_Mouse0.94571831
104LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94034041
105PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93906716
106NMYC_18555785_Chip-Seq_ESCs_Mouse0.93297786
107TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92896891
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92860766
109ESRRB_18555785_Chip-Seq_ESCs_Mouse0.92736491
110HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91621446
111E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91587537
112CRX_20693478_ChIP-Seq_RETINA_Mouse0.91393491
113NANOG_20526341_ChIP-Seq_ESCs_Human0.91355969
114AR_25329375_ChIP-Seq_VCAP_Human0.91031736
115NFYB_21822215_ChIP-Seq_K562_Human0.90709515
116CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90530273
117SPI1_26923725_Chip-Seq_HPCs_Mouse0.89238484
118KLF4_19829295_ChIP-Seq_ESCs_Human0.89183462
119LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89147376
120SOX2_18555785_Chip-Seq_ESCs_Mouse0.89034078
121KLF4_18555785_Chip-Seq_ESCs_Mouse0.88820496
122STAT1_20625510_ChIP-Seq_HELA_Human0.88536582
123CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88319797
124OCT4_18555785_Chip-Seq_ESCs_Mouse0.87459511
125UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87278215
126NANOG_18555785_ChIP-Seq_MESCs_Mouse0.87194022
127AR_21572438_ChIP-Seq_LNCaP_Human0.86651657
128* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.86553992
129IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86534987
130CBP_20019798_ChIP-Seq_JUKART_Human0.86534987
131PRDM14_20953172_ChIP-Seq_ESCs_Human0.86333096
132RUNX2_22187159_ChIP-Seq_PCA_Human0.83652034
133OCT4_19829295_ChIP-Seq_ESCs_Human0.82834206
134SMAD4_21799915_ChIP-Seq_A2780_Human0.78439113
135SMAD3_21741376_ChIP-Seq_EPCs_Human0.72380409
136SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.72327839
137EZH2_27304074_Chip-Seq_ESCs_Mouse0.67800551
138SMRT_27268052_Chip-Seq_Bcells_Human0.67590153
139BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.67577260
140P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.65054955
141KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.64922965
142NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.64758689
143DROSHA_22980978_ChIP-Seq_HELA_Human0.63987248
144SMAD3_21741376_ChIP-Seq_ESCs_Human0.61548584
145FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.61088952
146NR3C1_23031785_ChIP-Seq_PC12_Mouse0.61087613
147SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.60211125
148* CBP_21632823_ChIP-Seq_H3396_Human0.58611092
149E2F1_17053090_ChIP-ChIP_MCF-7_Human0.57839625
150STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.57778527
151RXR_22108803_ChIP-Seq_LS180_Human0.57582303
152CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.57060446
153REST_21632747_ChIP-Seq_MESCs_Mouse0.56734427
154SOX2_21211035_ChIP-Seq_LN229_Gbm0.56609868
155AHR_22903824_ChIP-Seq_MCF-7_Human0.56510800
156EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.56349358
157TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.56322514
158FOXO3_23340844_ChIP-Seq_DLD1_Human0.55533736
159PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.55166779
160ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.54341710
161ZNF217_24962896_ChIP-Seq_MCF-7_Human0.54134802
162SALL4_22934838_ChIP-ChIP_CD34+_Human0.53223849
163TP53_22573176_ChIP-Seq_HFKS_Human0.52439243
164IRF1_19129219_ChIP-ChIP_H3396_Human0.51746416
165AR_19668381_ChIP-Seq_PC3_Human0.51572632
166CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.51320732
167TAL1_26923725_Chip-Seq_HPCs_Mouse0.50913243
168CREB1_15753290_ChIP-ChIP_HEK293T_Human0.50112000
169PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.48870093

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect7.89684757
2MP0003646_muscle_fatigue7.19409469
3MP0008877_abnormal_DNA_methylation4.69628709
4MP0005646_abnormal_pituitary_gland3.66684280
5MP0008789_abnormal_olfactory_epithelium3.60943593
6MP0003693_abnormal_embryo_hatching3.45326770
7MP0003315_abnormal_perineum_morphology3.39934054
8MP0005395_other_phenotype3.34063867
9MP0005499_abnormal_olfactory_system3.26450503
10MP0005394_taste/olfaction_phenotype3.26450503
11MP0005451_abnormal_body_composition3.24401863
12MP0003699_abnormal_female_reproductive3.20775283
13MP0008057_abnormal_DNA_replication3.09359674
14MP0003890_abnormal_embryonic-extraembry2.90625630
15MP0001119_abnormal_female_reproductive2.86413840
16MP0005187_abnormal_penis_morphology2.85646128
17MP0000579_abnormal_nail_morphology2.74674642
18MP0001929_abnormal_gametogenesis2.65316172
19MP0010094_abnormal_chromosome_stability2.56450037
20MP0002138_abnormal_hepatobiliary_system2.51892914
21MP0004957_abnormal_blastocyst_morpholog2.43703008
22MP0006292_abnormal_olfactory_placode2.36145790
23MP0003077_abnormal_cell_cycle2.35855736
24MP0010030_abnormal_orbit_morphology2.31471311
25MP0000653_abnormal_sex_gland2.30303988
26MP0005257_abnormal_intraocular_pressure2.23371010
27MP0002210_abnormal_sex_determination2.22856625
28MP0003787_abnormal_imprinting2.19811187
29MP0003111_abnormal_nucleus_morphology2.12431316
30MP0002234_abnormal_pharynx_morphology1.95316401
31MP0010234_abnormal_vibrissa_follicle1.94729341
32MP0000566_synostosis1.87075760
33MP0002295_abnormal_pulmonary_circulatio1.73136988
34MP0002161_abnormal_fertility/fecundity1.70245863
35MP0003937_abnormal_limbs/digits/tail_de1.67442158
36MP0004859_abnormal_synaptic_plasticity1.62952865
37MP0003121_genomic_imprinting1.61743601
38MP0003950_abnormal_plasma_membrane1.60600853
39MP0010307_abnormal_tumor_latency1.59803101
40MP0003183_abnormal_peptide_metabolism1.56446404
41MP0002249_abnormal_larynx_morphology1.53350093
42MP0008932_abnormal_embryonic_tissue1.51048277
43MP0001529_abnormal_vocalization1.48881891
44MP0005360_urolithiasis1.47160039
45MP0001145_abnormal_male_reproductive1.46669382
46MP0005410_abnormal_fertilization1.44579627
47MP0008260_abnormal_autophagy1.40361178
48MP0002653_abnormal_ependyma_morphology1.35646719
49MP0000613_abnormal_salivary_gland1.33797588
50MP0002102_abnormal_ear_morphology1.28192467
51MP0000631_abnormal_neuroendocrine_gland1.27365887
52MP0001730_embryonic_growth_arrest1.24930746
53MP0001293_anophthalmia1.18254470
54MP0005408_hypopigmentation1.18168732
55MP0001905_abnormal_dopamine_level1.17085765
56MP0002282_abnormal_trachea_morphology1.13682580
57MP0003252_abnormal_bile_duct1.10228487
58MP0010678_abnormal_skin_adnexa1.05899721
59MP0001664_abnormal_digestion1.05319685
60MP0000762_abnormal_tongue_morphology1.04003155
61MP0009384_cardiac_valve_regurgitation1.03133505
62MP0005310_abnormal_salivary_gland1.03006699
63MP0005389_reproductive_system_phenotype1.01033447
64MP0002233_abnormal_nose_morphology1.00994004
65MP0002085_abnormal_embryonic_tissue1.00141025
66MP0003123_paternal_imprinting0.99831377
67MP0004185_abnormal_adipocyte_glucose0.99756426
68MP0000350_abnormal_cell_proliferation0.98880638
69MP0003880_abnormal_central_pattern0.98852985
70MP0009840_abnormal_foam_cell0.97430065
71MP0002332_abnormal_exercise_endurance0.95959582
72MP0003119_abnormal_digestive_system0.95120711
73MP0004036_abnormal_muscle_relaxation0.94701742
74MP0001919_abnormal_reproductive_system0.92499689
75MP0009379_abnormal_foot_pigmentation0.88413326
76MP0001666_abnormal_nutrient_absorption0.88052458
77MP0010386_abnormal_urinary_bladder0.87779073
78MP0005409_darkened_coat_color0.87756580
79MP0005380_embryogenesis_phenotype0.86258909
80MP0001672_abnormal_embryogenesis/_devel0.86258909
81MP0000639_abnormal_adrenal_gland0.85244912
82MP0002272_abnormal_nervous_system0.85140732
83MP0004142_abnormal_muscle_tone0.84570182
84MP0003959_abnormal_lean_body0.82687898
85MP0001984_abnormal_olfaction0.81623162
86MP0002837_dystrophic_cardiac_calcinosis0.77250047
87MP0001986_abnormal_taste_sensitivity0.76580184
88MP0003698_abnormal_male_reproductive0.76537057
89MP0000465_gastrointestinal_hemorrhage0.75801782
90MP0008875_abnormal_xenobiotic_pharmacok0.75379105
91MP0000678_abnormal_parathyroid_gland0.72604517
92MP0003868_abnormal_feces_composition0.72574648
93MP0005076_abnormal_cell_differentiation0.71157588
94MP0002089_abnormal_postnatal_growth/wei0.71090826
95MP0000733_abnormal_muscle_development0.70017979
96MP0002019_abnormal_tumor_incidence0.69951423
97MP0002139_abnormal_hepatobiliary_system0.69944730
98MP0009697_abnormal_copulation0.69297953
99MP0001324_abnormal_eye_pigmentation0.68723323
100MP0000383_abnormal_hair_follicle0.68308853
101MP0005085_abnormal_gallbladder_physiolo0.67822765
102MP0003755_abnormal_palate_morphology0.67034301
103MP0006276_abnormal_autonomic_nervous0.66410225
104MP0003941_abnormal_skin_development0.65655393
105MP0001346_abnormal_lacrimal_gland0.65587077
106MP0000049_abnormal_middle_ear0.64912103
107MP0005551_abnormal_eye_electrophysiolog0.64834932
108MP0002084_abnormal_developmental_patter0.63719529
109MP0002269_muscular_atrophy0.63021016
110MP0006072_abnormal_retinal_apoptosis0.62841145
111MP0002932_abnormal_joint_morphology0.62283934
112MP0002736_abnormal_nociception_after0.60993580
113MP0003942_abnormal_urinary_system0.60775824
114MP0010368_abnormal_lymphatic_system0.59515489
115MP0004264_abnormal_extraembryonic_tissu0.58816288
116MP0001502_abnormal_circadian_rhythm0.58789563
117MP0001697_abnormal_embryo_size0.58088246
118MP0003879_abnormal_hair_cell0.57932865
119MP0002127_abnormal_cardiovascular_syste0.56862745
120MP0000015_abnormal_ear_pigmentation0.56592274
121MP0004270_analgesia0.54450388
122MP0003136_yellow_coat_color0.53291647
123MP0003453_abnormal_keratinocyte_physiol0.52449035
124MP0003984_embryonic_growth_retardation0.51299846
125MP0005621_abnormal_cell_physiology0.50677072
126MP0002163_abnormal_gland_morphology0.49748911
127MP0008058_abnormal_DNA_repair0.49321321
128MP0002734_abnormal_mechanical_nocicepti0.49062138
129MP0001963_abnormal_hearing_physiology0.48711446
130MP0002160_abnormal_reproductive_system0.48076166
131MP0004484_altered_response_of0.47641551
132MP0008995_early_reproductive_senescence0.47533729
133MP0002088_abnormal_embryonic_growth/wei0.46886786
134MP0005647_abnormal_sex_gland0.46828146
135MP0000427_abnormal_hair_cycle0.46200147
136MP0002080_prenatal_lethality0.44598627
137MP0002098_abnormal_vibrissa_morphology0.44298665
138MP0004782_abnormal_surfactant_physiolog0.44093672
139MP0002928_abnormal_bile_duct0.43511682
140MP0005220_abnormal_exocrine_pancreas0.43044169
141MP0004510_myositis0.40933232
142MP0008007_abnormal_cellular_replicative0.40536041
143MP0000490_abnormal_crypts_of0.40255069
144MP0000377_abnormal_hair_follicle0.40122177
145MP0006138_congestive_heart_failure0.39903212
146MP0005501_abnormal_skin_physiology0.39527403
147MP0000470_abnormal_stomach_morphology0.39322063
148MP0003861_abnormal_nervous_system0.38904093
149MP0002796_impaired_skin_barrier0.38792763
150MP0000313_abnormal_cell_death0.37389233
151MP0003935_abnormal_craniofacial_develop0.37218663
152MP0003763_abnormal_thymus_physiology0.37067932
153MP0002873_normal_phenotype0.36785952
154MP0000462_abnormal_digestive_system0.35915017

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)8.27427216
2Cortical dysplasia (HP:0002539)7.32545691
3Premature ovarian failure (HP:0008209)7.06701731
4Infertility (HP:0000789)6.55887885
5Atelectasis (HP:0100750)5.34991621
6Abdominal situs inversus (HP:0003363)5.28335492
7Abnormality of abdominal situs (HP:0011620)5.28335492
8Secondary amenorrhea (HP:0000869)5.09457906
9Lip pit (HP:0100267)4.97045619
10Anosmia (HP:0000458)4.70068584
11Osteomalacia (HP:0002749)4.62024050
12Breast hypoplasia (HP:0003187)4.58806067
13Birth length less than 3rd percentile (HP:0003561)4.54347576
14Flat capital femoral epiphysis (HP:0003370)4.38232953
15Apathy (HP:0000741)3.97922505
16Aplasia/Hypoplasia of the breasts (HP:0010311)3.96680983
17Hypophosphatemic rickets (HP:0004912)3.93809860
18Breast aplasia (HP:0100783)3.90680260
19Abnormality of the fovea (HP:0000493)3.87375214
20Chromsome breakage (HP:0040012)3.85710822
21Pulmonary fibrosis (HP:0002206)3.82254044
22Septo-optic dysplasia (HP:0100842)3.79640604
23Diminished motivation (HP:0000745)3.78930268
24Myokymia (HP:0002411)3.67706533
25Hypogonadotrophic hypogonadism (HP:0000044)3.65074966
26Abnormality of the labia minora (HP:0012880)3.62615303
27Chromosomal breakage induced by crosslinking agents (HP:0003221)3.61578069
28Aplasia/Hypoplasia of the fovea (HP:0008060)3.54590429
29Hypoplasia of the fovea (HP:0007750)3.54590429
30Patellar aplasia (HP:0006443)3.53847487
31Papillary thyroid carcinoma (HP:0002895)3.51920789
32Insulin-resistant diabetes mellitus (HP:0000831)3.51871393
33Shawl scrotum (HP:0000049)3.44615034
34Hypergonadotropic hypogonadism (HP:0000815)3.44421893
35Azoospermia (HP:0000027)3.33392178
36Hypokinesia (HP:0002375)3.23367029
37Aplasia/Hypoplasia of the patella (HP:0006498)3.22366105
38Primary amenorrhea (HP:0000786)3.18846725
39Adrenal hypoplasia (HP:0000835)3.18285425
40Aplasia of the musculature (HP:0100854)3.02617572
41Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.93785074
42Gonadotropin excess (HP:0000837)2.93478169
43Delayed puberty (HP:0000823)2.89569851
44Nonprogressive disorder (HP:0003680)2.88902257
45Papilledema (HP:0001085)2.87762785
46Absent septum pellucidum (HP:0001331)2.85451900
47Truncal obesity (HP:0001956)2.79929315
48Facial hemangioma (HP:0000329)2.75117438
49Abnormality of the anterior chamber (HP:0000593)2.72443227
50Median cleft lip (HP:0000161)2.68022035
51Urethral obstruction (HP:0000796)2.67075620
52Lower limb hyperreflexia (HP:0002395)2.62499337
53Anterior segment dysgenesis (HP:0007700)2.58779514
54Thyroid carcinoma (HP:0002890)2.57573821
55Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.55583017
56Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.55272812
57Oligodactyly (HP:0012165)2.54790588
58Cholecystitis (HP:0001082)2.54720680
59Abnormal gallbladder physiology (HP:0012438)2.54720680
60Deep venous thrombosis (HP:0002625)2.53608870
61Spinal cord compression (HP:0002176)2.53529110
62Malnutrition (HP:0004395)2.52444440
63Abnormality of chromosome segregation (HP:0002916)2.51190176
64Abnormality of alanine metabolism (HP:0010916)2.49644553
65Hyperalaninemia (HP:0003348)2.49644553
66Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.49644553
67Abnormal spermatogenesis (HP:0008669)2.48384537
68Abnormality of placental membranes (HP:0011409)2.45316360
69Amniotic constriction ring (HP:0009775)2.45316360
70Skin pits (HP:0100276)2.43084434
71Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.40401430
72Oral leukoplakia (HP:0002745)2.40257177
73Bundle branch block (HP:0011710)2.37937623
74Abnormality of the septum pellucidum (HP:0007375)2.37881520
75Metaphyseal irregularity (HP:0003025)2.37062472
76Rhabdomyosarcoma (HP:0002859)2.36976887
77Bronchiectasis (HP:0002110)2.35455084
78Anhidrosis (HP:0000970)2.35373384
79Loss of speech (HP:0002371)2.32983593
80Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.29230913
81Hyperglycemia (HP:0003074)2.29128233
82Aplasia/Hypoplasia of the macula (HP:0008059)2.26931259
83Increased circulating renin level (HP:0000848)2.25845333
84Arterial tortuosity (HP:0005116)2.25499794
85Striae distensae (HP:0001065)2.23643341
86Dysdiadochokinesis (HP:0002075)2.23420272
87Erectile abnormalities (HP:0100639)2.22650324
88Abnormality of the proximal phalanges of the hand (HP:0009834)2.20313747
89Fetal akinesia sequence (HP:0001989)2.18281403
90Short tibia (HP:0005736)2.16582478
91Carpal bone hypoplasia (HP:0001498)2.16499259
92Subcapsular cataract (HP:0000523)2.12415882
93Impulsivity (HP:0100710)2.10489173
94Aplasia/Hypoplasia affecting the retina (HP:0008061)2.10313389
95Fibular aplasia (HP:0002990)2.09015787
96Fair hair (HP:0002286)2.08252320
97Supernumerary spleens (HP:0009799)2.07845185
98Aplastic anemia (HP:0001915)2.07362449
99Cone-rod dystrophy (HP:0000548)2.05176391
100Congenital sensorineural hearing impairment (HP:0008527)2.03716334
101Abnormality of the epiphysis of the femoral head (HP:0010574)2.01722505
102Enlarged penis (HP:0000040)2.01321767
103Maternal diabetes (HP:0009800)1.98487918
104Wrist flexion contracture (HP:0001239)1.98395888
105Intrahepatic cholestasis (HP:0001406)1.96740814
106Conjunctival telangiectasia (HP:0000524)1.95049396
107Sloping forehead (HP:0000340)1.94552442
108Muscle stiffness (HP:0003552)1.92132119
109Abnormality of midbrain morphology (HP:0002418)1.91636009
110Molar tooth sign on MRI (HP:0002419)1.91636009
111Neurofibrillary tangles (HP:0002185)1.91519910
112Vascular tortuosity (HP:0004948)1.90429867
113Abnormality of the femoral head (HP:0003368)1.89758061
114Abnormality of cochlea (HP:0000375)1.89417513
115Muscle fiber splitting (HP:0003555)1.87932966
116Supranuclear gaze palsy (HP:0000605)1.87368124
117Aplasia/Hypoplasia of the tibia (HP:0005772)1.87059342
118Chronic bronchitis (HP:0004469)1.87030388
119Aplasia/Hypoplasia of the tongue (HP:0010295)1.86827758
120Abnormal biliary tract physiology (HP:0012439)1.85562550
121Bile duct proliferation (HP:0001408)1.85562550
122Posterior subcapsular cataract (HP:0007787)1.85469687
123Dysmetric saccades (HP:0000641)1.85336082
124Sandal gap (HP:0001852)1.85328249
125Hypercortisolism (HP:0001578)1.83988154
126Decreased circulating renin level (HP:0003351)1.83846822
127Abnormality of the salivary glands (HP:0010286)1.83696113
128Heterotopia (HP:0002282)1.83254731
129Chorioretinal atrophy (HP:0000533)1.82615581
130Posterior embryotoxon (HP:0000627)1.82282209
131Aplasia/Hypoplasia of the uvula (HP:0010293)1.82225601
132Aplasia/Hypoplasia involving the musculature (HP:0001460)1.81233964
133Capillary hemangiomas (HP:0005306)1.80684740
134Abnormality of chromosome stability (HP:0003220)1.80316159
135Abnormality of femoral epiphyses (HP:0006499)1.80142430
136Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.80142430
137Proximal tubulopathy (HP:0000114)1.79882728
138Hyperactive renin-angiotensin system (HP:0000841)1.79400623
139Nephroblastoma (Wilms tumor) (HP:0002667)1.78536539
140Duodenal stenosis (HP:0100867)1.77287779
141Small intestinal stenosis (HP:0012848)1.77287779
142Hydroureter (HP:0000072)1.76967887
143Gynecomastia (HP:0000771)1.76734251
144Abnormality of the preputium (HP:0100587)1.75937553
145Acute myeloid leukemia (HP:0004808)1.75796198
146Tubulointerstitial nephritis (HP:0001970)1.75627465
147Abnormality of monocarboxylic acid metabolism (HP:0010996)1.75613522
148Arachnodactyly (HP:0001166)1.75016019
149Oligodactyly (hands) (HP:0001180)1.73669886
150Absent forearm bone (HP:0003953)1.73608229
151Aplasia involving forearm bones (HP:0009822)1.73608229
152Camptodactyly of toe (HP:0001836)1.73512958
153Midline defect of the nose (HP:0004122)1.72408558
154Abnormality of the line of Schwalbe (HP:0008048)1.71365325
155Absent radius (HP:0003974)1.71227106
156Abnormality of the phalanges of the hallux (HP:0010057)1.70996599
157Muscle fiber atrophy (HP:0100295)1.69608996
158Non-midline cleft lip (HP:0100335)1.68844178
159Irregular epiphyses (HP:0010582)1.67917687
160Hip contracture (HP:0003273)1.67551939
161Embryonal renal neoplasm (HP:0011794)1.67546733
162Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.67462886
163Villous atrophy (HP:0011473)1.67430728
164Abnormality of small intestinal villus morphology (HP:0011472)1.67430728
165Absent hand (HP:0004050)1.66445849
166Type 2 muscle fiber atrophy (HP:0003554)1.66205324
167Meckel diverticulum (HP:0002245)1.65921752

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K65.74865880
2CDK125.02397776
3ERBB44.60503952
4LATS23.95927202
5LATS13.39476490
6TAOK33.34846720
7PRKD33.24516390
8KSR23.19239328
9NEK63.14886972
10TTK2.90808363
11MOS2.85632732
12BMPR22.64404149
13MET2.64192224
14STK38L2.43213487
15BRAF2.39716492
16EEF2K2.30840036
17MAP3K92.30532772
18CDK82.25735456
19PLK41.99644893
20CHEK21.93057071
21MUSK1.81256387
22TRIM281.80368952
23MELK1.79751168
24STK101.75838468
25CAMK1D1.75820618
26MAP3K41.68598988
27STK31.64626266
28MAP2K71.59757049
29NEK21.54061333
30PRKCI1.52024249
31MAPK131.47260950
32TNIK1.41066368
33TAOK11.40175698
34BUB11.37067879
35PLK11.35100621
36PTK21.33386245
37DYRK21.32703923
38CDC71.31062770
39CAMK1G1.30313563
40MAP3K131.30290265
41ARAF1.28780492
42MAPKAPK31.23279952
43MAPKAPK51.21190976
44WNK11.20424014
45RAF11.15098472
46MAP3K81.11540075
47PAK61.06302484
48MAP2K41.04478630
49AURKA1.03530093
50EPHA40.99431243
51TGFBR10.98252459
52BRD40.97344967
53MTOR0.92874492
54MAP3K20.90477027
55ACVR1B0.89835209
56CSNK1G10.87619877
57PIM10.85968618
58PRKD20.85887230
59RET0.83157173
60EIF2AK30.79531911
61AURKB0.78109804
62TNK20.74685174
63ABL20.74166306
64KSR10.73867373
65TYRO30.72273105
66MST40.71635586
67STK240.71295465
68PLK30.70136408
69MARK30.69506268
70CSNK1G20.67918502
71STK380.67132417
72DMPK0.65894820
73CSNK1G30.64954907
74TIE10.59240761
75CDK90.58728593
76CASK0.58689411
77EIF2AK10.57926585
78PRKCZ0.56074694
79PLK20.55781317
80ZAK0.54688220
81PRKAA10.54114070
82CCNB10.53025770
83BMPR1B0.52990385
84NTRK20.48726588
85NEK90.48216139
86STK390.48203574
87NTRK30.46977596
88MAP3K10.45969894
89MAP3K50.45289654
90NLK0.44988435
91CSNK1E0.43726192
92MAPK110.43212116
93CSNK1A1L0.43145883
94PINK10.42428776
95PRKG10.42330478
96CDK50.42310172
97CHEK10.40881140
98ATR0.40370575
99VRK10.38595110
100CDC42BPA0.38115681
101TRPM70.38035291
102PKN10.38013599
103CAMK40.37954423
104GSK3B0.37420843
105NUAK10.37406639
106MAPK100.37334452
107PDK10.36560136
108BRSK10.36394410
109ATM0.35369452
110SGK2230.34806675
111SGK4940.34806675
112BRSK20.34574948
113CLK10.34433197
114CDK190.33707124
115MARK20.33250682
116PRKAA20.31337596
117CDK10.31331835
118MAPK10.30468451
119ZAP700.30237537
120ABL10.29364975
121LRRK20.29141668
122CDK30.28686078
123CDK70.28308329
124CDK40.28215040
125DYRK30.27012317
126SGK20.26419251
127SRPK10.26379122
128CHUK0.25737692
129MAP3K70.25386608
130AKT20.24646287
131CAMK10.24539190
132NME10.23722883
133CAMK2A0.23126518
134PRKACB0.22943298
135STK110.22856813
136CDK20.22713762
137TLK10.22470479
138PDPK10.21191146
139RPS6KB20.20988404
140OXSR10.20818881
141MAP2K10.20578056
142PDK30.20551837
143PDK40.20551837
144CSNK1D0.19735366
145CSNK1A10.16117989
146MAP3K120.14801107
147PRKCH0.14535279
148HIPK20.14208520
149PAK10.13186786
150AKT10.12583390

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049134.40545962
2Vitamin B6 metabolism_Homo sapiens_hsa007504.34899993
3Basal transcription factors_Homo sapiens_hsa030223.61604882
4Cell cycle_Homo sapiens_hsa041103.27324100
5RNA degradation_Homo sapiens_hsa030182.84804054
6RNA polymerase_Homo sapiens_hsa030202.66823867
7Oocyte meiosis_Homo sapiens_hsa041142.59687261
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.49132361
9GnRH signaling pathway_Homo sapiens_hsa049122.39809748
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.35904695
11RNA transport_Homo sapiens_hsa030132.32381216
12Dorso-ventral axis formation_Homo sapiens_hsa043202.31242413
13Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.26211484
14Fanconi anemia pathway_Homo sapiens_hsa034602.23191770
15Caffeine metabolism_Homo sapiens_hsa002322.15778232
16Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.14573384
17Homologous recombination_Homo sapiens_hsa034402.14453435
18Circadian rhythm_Homo sapiens_hsa047102.09335082
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.07894639
20Linoleic acid metabolism_Homo sapiens_hsa005912.04018197
21Ether lipid metabolism_Homo sapiens_hsa005651.87154694
22Pancreatic cancer_Homo sapiens_hsa052121.80536601
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.60221866
24mTOR signaling pathway_Homo sapiens_hsa041501.58431684
25Olfactory transduction_Homo sapiens_hsa047401.49222917
26Base excision repair_Homo sapiens_hsa034101.38452090
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.35619665
28Glycerophospholipid metabolism_Homo sapiens_hsa005641.34913582
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.29803541
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28313647
31Inositol phosphate metabolism_Homo sapiens_hsa005621.24918982
32Phototransduction_Homo sapiens_hsa047441.23447274
33mRNA surveillance pathway_Homo sapiens_hsa030151.22223904
34Colorectal cancer_Homo sapiens_hsa052101.18535931
35Long-term depression_Homo sapiens_hsa047301.17856212
36MicroRNAs in cancer_Homo sapiens_hsa052061.17653615
37VEGF signaling pathway_Homo sapiens_hsa043701.15894320
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.14507483
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.12309942
40ABC transporters_Homo sapiens_hsa020101.11044341
41Renal cell carcinoma_Homo sapiens_hsa052111.10686035
42Choline metabolism in cancer_Homo sapiens_hsa052311.09423826
43Lysine degradation_Homo sapiens_hsa003101.08274608
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05666355
45TGF-beta signaling pathway_Homo sapiens_hsa043501.04030014
46Prolactin signaling pathway_Homo sapiens_hsa049171.03076996
47Longevity regulating pathway - mammal_Homo sapiens_hsa042111.01886504
48Non-homologous end-joining_Homo sapiens_hsa034501.00558922
49p53 signaling pathway_Homo sapiens_hsa041150.94910851
50Folate biosynthesis_Homo sapiens_hsa007900.93090123
51Other glycan degradation_Homo sapiens_hsa005110.91965923
52Nucleotide excision repair_Homo sapiens_hsa034200.87146556
53GABAergic synapse_Homo sapiens_hsa047270.87022240
54Bile secretion_Homo sapiens_hsa049760.86504607
55Purine metabolism_Homo sapiens_hsa002300.86136352
56Bladder cancer_Homo sapiens_hsa052190.83414793
57Taste transduction_Homo sapiens_hsa047420.81422497
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80125878
59Morphine addiction_Homo sapiens_hsa050320.79823604
60Glutamatergic synapse_Homo sapiens_hsa047240.72236209
61Ras signaling pathway_Homo sapiens_hsa040140.71809373
62Notch signaling pathway_Homo sapiens_hsa043300.70047533
63Regulation of autophagy_Homo sapiens_hsa041400.67839487
64Sphingolipid metabolism_Homo sapiens_hsa006000.66928968
65Non-small cell lung cancer_Homo sapiens_hsa052230.64863817
66Serotonergic synapse_Homo sapiens_hsa047260.63521196
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63072300
68Mismatch repair_Homo sapiens_hsa034300.62819453
69Pyrimidine metabolism_Homo sapiens_hsa002400.62093435
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60380922
71Pyruvate metabolism_Homo sapiens_hsa006200.60234854
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60186202
73Long-term potentiation_Homo sapiens_hsa047200.57357998
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.57103213
75Gap junction_Homo sapiens_hsa045400.56872500
76Estrogen signaling pathway_Homo sapiens_hsa049150.54825784
77Glioma_Homo sapiens_hsa052140.54655208
78DNA replication_Homo sapiens_hsa030300.53330153
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53032227
80Melanoma_Homo sapiens_hsa052180.52743251
81Wnt signaling pathway_Homo sapiens_hsa043100.52424188
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51797530
83Nicotine addiction_Homo sapiens_hsa050330.51762704
84FoxO signaling pathway_Homo sapiens_hsa040680.51576878
85Endometrial cancer_Homo sapiens_hsa052130.51533823
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50863505
87Hippo signaling pathway_Homo sapiens_hsa043900.50360763
88Herpes simplex infection_Homo sapiens_hsa051680.50286671
89Arginine biosynthesis_Homo sapiens_hsa002200.48264206
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46450578
91Oxytocin signaling pathway_Homo sapiens_hsa049210.44549669
92MAPK signaling pathway_Homo sapiens_hsa040100.43797012
93Arginine and proline metabolism_Homo sapiens_hsa003300.43349905
94Vitamin digestion and absorption_Homo sapiens_hsa049770.42076577
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42047772
96Shigellosis_Homo sapiens_hsa051310.41636706
97Thyroid cancer_Homo sapiens_hsa052160.40329321
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36659910
99Small cell lung cancer_Homo sapiens_hsa052220.35101054
100Arachidonic acid metabolism_Homo sapiens_hsa005900.34304902
101Viral carcinogenesis_Homo sapiens_hsa052030.34296356
102Phagosome_Homo sapiens_hsa041450.32050822
103Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31674699
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.30700982
105Prostate cancer_Homo sapiens_hsa052150.30237050
106HIF-1 signaling pathway_Homo sapiens_hsa040660.29894408
107Insulin signaling pathway_Homo sapiens_hsa049100.29706996
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.28437338
109ErbB signaling pathway_Homo sapiens_hsa040120.27965436
110Synaptic vesicle cycle_Homo sapiens_hsa047210.27762402
111Influenza A_Homo sapiens_hsa051640.26026563
112cAMP signaling pathway_Homo sapiens_hsa040240.25865449
113Amoebiasis_Homo sapiens_hsa051460.25813125
114Chronic myeloid leukemia_Homo sapiens_hsa052200.25689187
115Huntingtons disease_Homo sapiens_hsa050160.24546371
116Histidine metabolism_Homo sapiens_hsa003400.23541361
117HTLV-I infection_Homo sapiens_hsa051660.22093951
118Protein digestion and absorption_Homo sapiens_hsa049740.21893788
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.21822395
120cGMP-PKG signaling pathway_Homo sapiens_hsa040220.21337083
121Fatty acid elongation_Homo sapiens_hsa000620.20688644
122beta-Alanine metabolism_Homo sapiens_hsa004100.19572739
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.19223185
124Adherens junction_Homo sapiens_hsa045200.18673666
125Salivary secretion_Homo sapiens_hsa049700.18671363
126Melanogenesis_Homo sapiens_hsa049160.18507060
127Hepatitis B_Homo sapiens_hsa051610.18335532
128Cholinergic synapse_Homo sapiens_hsa047250.18230599
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.17964883
130Primary bile acid biosynthesis_Homo sapiens_hsa001200.17223435
131Circadian entrainment_Homo sapiens_hsa047130.15768261
132Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.15556033
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.15278785
134Peroxisome_Homo sapiens_hsa041460.15256112
135Calcium signaling pathway_Homo sapiens_hsa040200.13330431
136Insulin secretion_Homo sapiens_hsa049110.11453541
137Tight junction_Homo sapiens_hsa045300.10680446

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