ZBED1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It was earlier identified as a gene with similarity to Ac transposable elements, however, was found not to have transposase activity. Later studies show that this gene product is localized in the nucleus and functions as a transcription factor. It binds to DNA elements found in the promoter regions of several genes related to cell proliferation, such as histone H1, hence may have a role in regulating genes related to cell proliferation. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.07310720
2positive regulation by organism of defense response of other organism involved in symbiotic interact4.07310720
3modulation by symbiont of host immune response (GO:0052553)4.07310720
4positive regulation by symbiont of host defense response (GO:0052509)4.07310720
5modulation by symbiont of host defense response (GO:0052031)4.07310720
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.07310720
7response to peptidoglycan (GO:0032494)3.99917592
8negative regulation of erythrocyte differentiation (GO:0045647)3.96524798
9positive regulation of gamma-delta T cell activation (GO:0046645)3.75965560
10response to muramyl dipeptide (GO:0032495)3.52087231
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.37052852
12negative regulation of cell killing (GO:0031342)3.26121365
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.26121365
14antigen processing and presentation of endogenous antigen (GO:0019883)3.24265382
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.22961108
16macrophage activation involved in immune response (GO:0002281)3.17304585
17regulation of necroptotic process (GO:0060544)3.10589479
18regulation of gamma-delta T cell activation (GO:0046643)3.09485513
19negative regulation of necroptotic process (GO:0060546)3.09102586
203-UTR-mediated mRNA stabilization (GO:0070935)3.08963245
21barbed-end actin filament capping (GO:0051016)2.99961251
22detection of other organism (GO:0098543)2.98349146
23pinocytosis (GO:0006907)2.92243936
24NIK/NF-kappaB signaling (GO:0038061)2.90201734
25negative regulation of interleukin-12 production (GO:0032695)2.88577103
26mannose metabolic process (GO:0006013)2.88252921
27detection of bacterium (GO:0016045)2.87064626
28detection of molecule of bacterial origin (GO:0032490)2.81637778
29regulation of cholesterol storage (GO:0010885)2.76061852
30negative regulation of toll-like receptor signaling pathway (GO:0034122)2.73254846
31detection of external biotic stimulus (GO:0098581)2.72943933
32regulation of interferon-beta biosynthetic process (GO:0045357)2.72306933
33alpha-linolenic acid metabolic process (GO:0036109)2.70543698
34germinal center formation (GO:0002467)2.69660226
35immunoglobulin mediated immune response (GO:0016064)2.69595079
36regulation of gamma-delta T cell differentiation (GO:0045586)2.69462709
37response to laminar fluid shear stress (GO:0034616)2.67872729
38type I interferon signaling pathway (GO:0060337)2.66855490
39cellular response to type I interferon (GO:0071357)2.66855490
40response to type I interferon (GO:0034340)2.65571970
41response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.65552701
42response to host immune response (GO:0052572)2.65552701
43cellular hyperosmotic response (GO:0071474)2.63834122
44CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.58217893
45regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.58200159
46positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.57562603
47glycosphingolipid catabolic process (GO:0046479)2.57378757
48tricarboxylic acid metabolic process (GO:0072350)2.56462555
49fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.55197927
50protein localization to endosome (GO:0036010)2.55035666
51regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.54736050
52positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.54263180
53urea cycle (GO:0000050)2.54226936
54negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.53112816
55regulation of necrotic cell death (GO:0010939)2.52509027
56response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.51486946
57response to host (GO:0075136)2.51486946
58response to host defenses (GO:0052200)2.51486946
59negative regulation of granulocyte differentiation (GO:0030853)2.50510492
60regulation of monocyte differentiation (GO:0045655)2.49864977
61histone H3-K36 demethylation (GO:0070544)2.49039301
62embryonic process involved in female pregnancy (GO:0060136)2.48772104
63creatine metabolic process (GO:0006600)2.47841574
64antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.46832987
65positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.44069350
66regulation of B cell receptor signaling pathway (GO:0050855)2.43701354
67positive regulation of B cell differentiation (GO:0045579)2.43143803
68detection of biotic stimulus (GO:0009595)2.43094452
69epithelial cell differentiation involved in prostate gland development (GO:0060742)2.42782787
70negative regulation of innate immune response (GO:0045824)2.42525531
71positive regulation of triglyceride lipase activity (GO:0061365)2.41945368
72positive regulation of lipoprotein lipase activity (GO:0051006)2.41945368
73low-density lipoprotein particle clearance (GO:0034383)2.41581139
74regulation of antigen processing and presentation (GO:0002577)2.41551304
75urea metabolic process (GO:0019627)2.41063675
76response to mercury ion (GO:0046689)2.40368249
77cellular response to thyroid hormone stimulus (GO:0097067)2.37228166
78regulation of type I interferon-mediated signaling pathway (GO:0060338)2.37129682
79glycolipid catabolic process (GO:0019377)2.36759229
80regulation of dendritic cell antigen processing and presentation (GO:0002604)2.35934278
81defense response to protozoan (GO:0042832)2.35748166
82regulation of leukocyte degranulation (GO:0043300)2.35744445
83regulation of mast cell degranulation (GO:0043304)2.35702967
84positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.34766436
85positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.34732944
86regulation of cholesterol homeostasis (GO:2000188)2.34483212
87lipopolysaccharide-mediated signaling pathway (GO:0031663)2.33203401
88NADH metabolic process (GO:0006734)2.30160025
89interferon-gamma-mediated signaling pathway (GO:0060333)2.28756889
90regulation of myeloid leukocyte mediated immunity (GO:0002886)2.27234330
91nitrogen cycle metabolic process (GO:0071941)2.25229464
92modulation by symbiont of host cellular process (GO:0044068)2.25035305
93positive regulation of tumor necrosis factor production (GO:0032760)2.24605065
94regulation of vitamin metabolic process (GO:0030656)2.23881191
95respiratory burst (GO:0045730)2.23397629
96response to protozoan (GO:0001562)2.23324375
97endothelium development (GO:0003158)2.23284110
98negative regulation of necrotic cell death (GO:0060547)2.22717176
99positive regulation of cholesterol efflux (GO:0010875)2.22483209
100negative regulation of blood vessel endothelial cell migration (GO:0043537)2.21586391

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.49458549
2VDR_21846776_ChIP-Seq_THP-1_Human3.24672861
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.16458705
4MYC_22102868_ChIP-Seq_BL_Human2.94601006
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.72797991
6LXR_22292898_ChIP-Seq_THP-1_Human2.61506246
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.59604933
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.56545357
9NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.49615956
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.48028330
11VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.22733472
12ELK3_25401928_ChIP-Seq_HUVEC_Human2.20178379
13VDR_24763502_ChIP-Seq_THP-1_Human2.15008971
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.13718598
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.13387740
16TCF7_22412390_ChIP-Seq_EML_Mouse2.11089740
17KDM2B_26808549_Chip-Seq_DND41_Human2.08556716
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.08115216
19ZNF263_19887448_ChIP-Seq_K562_Human2.04624564
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.95526046
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.95478388
22E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.90821955
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89756519
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.82155734
25MAF_26560356_Chip-Seq_TH1_Human1.77518235
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.75557414
27IRF8_21731497_ChIP-ChIP_J774_Mouse1.74427582
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73919338
29RACK7_27058665_Chip-Seq_MCF-7_Human1.70623006
30RXR_22158963_ChIP-Seq_LIVER_Mouse1.70443042
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.69717742
32FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.67983400
33SCL_19346495_ChIP-Seq_HPC-7_Human1.65792640
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.62491894
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.60882766
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.60482731
37KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.59875851
38UTX_26944678_Chip-Seq_JUKART_Human1.59847553
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.53757789
40CLOCK_20551151_ChIP-Seq_293T_Human1.53259838
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.52042929
42PPARA_22158963_ChIP-Seq_LIVER_Mouse1.50663474
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.47790098
44MAF_26560356_Chip-Seq_TH2_Human1.45162156
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.42248940
46TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40882596
47KDM2B_26808549_Chip-Seq_K562_Human1.39865595
48GATA1_19941827_ChIP-Seq_MEL_Mouse1.37262756
49GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34320342
50SPI1_23127762_ChIP-Seq_K562_Human1.34060002
51IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.31698538
52SMC4_20622854_ChIP-Seq_HELA_Human1.30724910
53STAT4_19710469_ChIP-ChIP_TH1__Mouse1.30599010
54TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30472294
55PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28836741
56CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27748462
57KDM2B_26808549_Chip-Seq_JURKAT_Human1.25868309
58P68_20966046_ChIP-Seq_HELA_Human1.25227181
59SA1_27219007_Chip-Seq_ERYTHROID_Human1.23752602
60DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23290545
61TP63_17297297_ChIP-ChIP_HaCaT_Human1.22866623
62Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.22718353
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22474031
64RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21293258
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20949727
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20662136
67BCOR_27268052_Chip-Seq_Bcells_Human1.19875604
68ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19412846
69CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18628852
70GATA1_22025678_ChIP-Seq_K562_Human1.18093853
71SPI1_23547873_ChIP-Seq_NB4_Human1.17505089
72STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.17351490
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17118114
74MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.17115897
75SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.15125182
76CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.14880027
77SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14137088
78UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13785506
79PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13757874
80SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13523360
81TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13267303
82LXR_22158963_ChIP-Seq_LIVER_Mouse1.11802544
83NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.11635270
84ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10039296
85EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09543961
86TBX20_22080862_ChIP-Seq_HEART_Mouse1.09251911
87TBX20_22328084_ChIP-Seq_HEART_Mouse1.09251911
88FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.08503717
89TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08105678
90TET1_21451524_ChIP-Seq_MESCs_Mouse1.07971051
91KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06033509
92MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05577060
93BCL6_27268052_Chip-Seq_Bcells_Human1.04319748
94NCOR1_26117541_ChIP-Seq_K562_Human1.04031617
95GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02848759
96ELF1_20517297_ChIP-Seq_JURKAT_Human1.02364660
97CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01484080
98GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00279262
99PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00224480
100KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99823318

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.76563612
2MP0005058_abnormal_lysosome_morphology3.18043491
3MP0009840_abnormal_foam_cell3.05540593
4MP0003705_abnormal_hypodermis_morpholog3.01961451
5MP0005451_abnormal_body_composition2.91663113
6MP0003724_increased_susceptibility_to2.88811530
7MP0003436_decreased_susceptibility_to2.74079581
8MP0009278_abnormal_bone_marrow2.59148206
9MP0003300_gastrointestinal_ulcer2.20940464
10MP0000685_abnormal_immune_system2.17773013
11MP0002139_abnormal_hepatobiliary_system2.07956371
12MP0008004_abnormal_stomach_pH2.05396447
13MP0002419_abnormal_innate_immunity2.02781602
14MP0008260_abnormal_autophagy1.99607688
15MP0003183_abnormal_peptide_metabolism1.98928128
16MP0001835_abnormal_antigen_presentation1.98883455
17MP0001790_abnormal_immune_system1.91942454
18MP0005387_immune_system_phenotype1.91942454
19MP0005025_abnormal_response_to1.83100447
20MP0005000_abnormal_immune_tolerance1.82295338
21MP0005360_urolithiasis1.80922666
22MP0005076_abnormal_cell_differentiation1.76824809
23MP0004510_myositis1.74672587
24MP0003191_abnormal_cellular_cholesterol1.72867640
25MP0001800_abnormal_humoral_immune1.71699659
26MP0009785_altered_susceptibility_to1.67276167
27MP0003172_abnormal_lysosome_physiology1.63448110
28MP0001849_ear_inflammation1.61819591
29MP0000747_muscle_weakness1.60936992
30MP0005397_hematopoietic_system_phenotyp1.60130671
31MP0001545_abnormal_hematopoietic_system1.60130671
32MP0000751_myopathy1.57937053
33MP0002452_abnormal_antigen_presenting1.57111181
34MP0002148_abnormal_hypersensitivity_rea1.55684215
35MP0001533_abnormal_skeleton_physiology1.55169355
36MP0002723_abnormal_immune_serum1.47835081
37MP0003763_abnormal_thymus_physiology1.45735930
38MP0000465_gastrointestinal_hemorrhage1.44041460
39MP0002420_abnormal_adaptive_immunity1.43205099
40MP0001819_abnormal_immune_cell1.41715778
41MP0002998_abnormal_bone_remodeling1.40930469
42MP0003075_altered_response_to1.40122075
43MP0005671_abnormal_response_to1.39421555
44MP0004947_skin_inflammation1.39039157
45MP0009333_abnormal_splenocyte_physiolog1.38599209
46MP0010155_abnormal_intestine_physiology1.36405993
47MP0003091_abnormal_cell_migration1.33076746
48MP0004233_abnormal_muscle_weight1.31638051
49MP0002138_abnormal_hepatobiliary_system1.29801471
50MP0003828_pulmonary_edema1.24627431
51MP0003806_abnormal_nucleotide_metabolis1.22008243
52MP0000750_abnormal_muscle_regeneration1.20617609
53MP0005464_abnormal_platelet_physiology1.20476481
54MP0000759_abnormal_skeletal_muscle1.18720755
55MP0000749_muscle_degeneration1.18365679
56MP0005166_decreased_susceptibility_to1.18289396
57MP0000858_altered_metastatic_potential1.16794730
58MP0001845_abnormal_inflammatory_respons1.16319210
59MP0003453_abnormal_keratinocyte_physiol1.16153538
60MP0004087_abnormal_muscle_fiber1.15787702
61MP0000604_amyloidosis1.15720403
62MP0008469_abnormal_protein_level1.12462341
63MP0000343_altered_response_to1.09808082
64MP0000716_abnormal_immune_system1.09415049
65MP0005330_cardiomyopathy1.06938526
66MP0002132_abnormal_respiratory_system1.06919962
67MP0004858_abnormal_nervous_system1.05617229
68MP0002398_abnormal_bone_marrow1.05035021
69MP0003566_abnormal_cell_adhesion1.03192942
70MP0002396_abnormal_hematopoietic_system1.02165943
71MP0002332_abnormal_exercise_endurance0.99283617
72MP0006082_CNS_inflammation0.99081317
73MP0001851_eye_inflammation0.97298219
74MP0000490_abnormal_crypts_of0.96534540
75MP0005670_abnormal_white_adipose0.96118387
76MP0005167_abnormal_blood-brain_barrier0.95806443
77MP0002405_respiratory_system_inflammati0.94341306
78MP0002254_reproductive_system_inflammat0.94167373
79MP0000013_abnormal_adipose_tissue0.93798932
80MP0000003_abnormal_adipose_tissue0.93457702
81MP0005375_adipose_tissue_phenotype0.92247014
82MP0001661_extended_life_span0.91465457
83MP0005365_abnormal_bile_salt0.91193127
84MP0002722_abnormal_immune_system0.90760458
85MP0002429_abnormal_blood_cell0.90061954
86MP0005666_abnormal_adipose_tissue0.88652915
87MP0010630_abnormal_cardiac_muscle0.88347517
88MP0004130_abnormal_muscle_cell0.88081053
89MP0000689_abnormal_spleen_morphology0.86358751
90MP0005165_increased_susceptibility_to0.86339801
91MP0010368_abnormal_lymphatic_system0.84937024
92MP0003279_aneurysm0.83863374
93MP0003646_muscle_fatigue0.82952486
94MP0004036_abnormal_muscle_relaxation0.81953411
95MP0002269_muscular_atrophy0.81213325
96MP0009764_decreased_sensitivity_to0.79889524
97MP0000249_abnormal_blood_vessel0.79112133
98MP0002971_abnormal_brown_adipose0.78982166
99MP0002796_impaired_skin_barrier0.78810007
100MP0000733_abnormal_muscle_development0.78570782

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)4.04723434
2Centrally nucleated skeletal muscle fibers (HP:0003687)3.96644739
3Eczematoid dermatitis (HP:0000976)3.77090051
4Spontaneous hematomas (HP:0007420)3.72840984
5Systemic lupus erythematosus (HP:0002725)3.61944100
6Myopathic facies (HP:0002058)3.10704113
7Muscle fiber inclusion bodies (HP:0100299)3.01917019
8Abnormality of skeletal muscle fiber size (HP:0012084)2.99907371
9Abnormality of glycolipid metabolism (HP:0010969)2.98269129
10Abnormality of liposaccharide metabolism (HP:0010968)2.98269129
11Abnormality of glycosphingolipid metabolism (HP:0004343)2.98269129
12Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.92463220
13Increased variability in muscle fiber diameter (HP:0003557)2.91637493
14Colitis (HP:0002583)2.90117915
15Recurrent abscess formation (HP:0002722)2.86636103
16Myositis (HP:0100614)2.74445346
17Nemaline bodies (HP:0003798)2.74007165
18Recurrent gram-negative bacterial infections (HP:0005420)2.72421504
19Abnormality of macrophages (HP:0004311)2.71190889
20Type 1 muscle fiber predominance (HP:0003803)2.70461731
21EMG: myopathic abnormalities (HP:0003458)2.69188723
22Asymmetric septal hypertrophy (HP:0001670)2.65454839
23Increased connective tissue (HP:0009025)2.64360784
24Mediastinal lymphadenopathy (HP:0100721)2.63100935
25Cellulitis (HP:0100658)2.62612565
26Increased cerebral lipofuscin (HP:0011813)2.58997745
27Hyporeflexia of lower limbs (HP:0002600)2.54951654
28Recurrent bacterial skin infections (HP:0005406)2.53784841
29Orchitis (HP:0100796)2.46715937
30Complement deficiency (HP:0004431)2.45100202
31Increased IgE level (HP:0003212)2.40362155
32Muscle fiber splitting (HP:0003555)2.39957822
33Thoracic kyphosis (HP:0002942)2.37967379
34Distal lower limb amyotrophy (HP:0008944)2.37424804
35Abnormality of complement system (HP:0005339)2.36001474
36Myocardial infarction (HP:0001658)2.35932728
37Distal lower limb muscle weakness (HP:0009053)2.35285740
38Abnormality of monocarboxylic acid metabolism (HP:0010996)2.33183639
39Difficulty climbing stairs (HP:0003551)2.29997411
40Rhabdomyolysis (HP:0003201)2.29333142
41Esophageal varix (HP:0002040)2.28449709
42Purpura (HP:0000979)2.22679866
43Gastrointestinal inflammation (HP:0004386)2.18990869
44Exercise-induced muscle cramps (HP:0003710)2.18941768
45Dysostosis multiplex (HP:0000943)2.17382981
46Bulbar palsy (HP:0001283)2.16648584
47Fatigue (HP:0012378)2.16606029
48Difficulty running (HP:0009046)2.14939045
49Scapular winging (HP:0003691)2.11572459
50Stroke (HP:0001297)2.10282585
51Hemorrhage of the eye (HP:0011885)2.08831996
52Ragged-red muscle fibers (HP:0003200)2.05139121
53Gastrointestinal stroma tumor (HP:0100723)2.04668561
54Glomerulonephritis (HP:0000099)2.04484330
55Meningitis (HP:0001287)2.03210493
56Increased neuronal autofluorescent lipopigment (HP:0002074)2.02988909
57Rimmed vacuoles (HP:0003805)2.01769321
58Spinal rigidity (HP:0003306)2.01713230
59Abnormality of the thoracic spine (HP:0100711)2.00166990
60Restrictive lung disease (HP:0002091)1.99043949
61Inflammation of the large intestine (HP:0002037)1.98285619
62Gingivitis (HP:0000230)1.98194065
63Amyloidosis (HP:0011034)1.97658425
64Retrobulbar optic neuritis (HP:0100654)1.96682137
65Optic neuritis (HP:0100653)1.96682137
66Loss of speech (HP:0002371)1.95658949
67Cerebral aneurysm (HP:0004944)1.95605377
68Visceral angiomatosis (HP:0100761)1.94812903
69Increased serum ferritin (HP:0003281)1.92106272
70Pulmonary embolism (HP:0002204)1.91572521
71Arterial thrombosis (HP:0004420)1.91342529
72Vertebral compression fractures (HP:0002953)1.90482755
73Protrusio acetabuli (HP:0003179)1.90481145
74Achilles tendon contracture (HP:0001771)1.89300889
75Polygenic inheritance (HP:0010982)1.89090239
76Hypertensive crisis (HP:0100735)1.88277073
77Hemoptysis (HP:0002105)1.88147556
78Hemangiomatosis (HP:0007461)1.86435621
79Deep venous thrombosis (HP:0002625)1.86024855
80Gastrointestinal infarctions (HP:0005244)1.82939720
81Obstructive lung disease (HP:0006536)1.82247997
82Chronic obstructive pulmonary disease (HP:0006510)1.82247997
83Myoglobinuria (HP:0002913)1.82069930
84Back pain (HP:0003418)1.80747075
85Abnormality of the Achilles tendon (HP:0005109)1.80263350
86Muscle stiffness (HP:0003552)1.79320078
87Thin bony cortex (HP:0002753)1.79027653
88Abnormality of mucopolysaccharide metabolism (HP:0011020)1.78427900
89Abnormality of polysaccharide metabolism (HP:0011012)1.78427900
90Abnormality of glycosaminoglycan metabolism (HP:0004371)1.78427900
91Epistaxis (HP:0000421)1.77128302
92Persistence of primary teeth (HP:0006335)1.76676729
93Elevated erythrocyte sedimentation rate (HP:0003565)1.76364962
94Recurrent fungal infections (HP:0002841)1.76298287
95Progressive muscle weakness (HP:0003323)1.76281296
96Abnormality of the peritoneum (HP:0002585)1.74282197
97Urticaria (HP:0001025)1.73366721
98Emphysema (HP:0002097)1.72753246
99Segmental peripheral demyelination/remyelination (HP:0003481)1.72749424
100Vasculitis (HP:0002633)1.72700592

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.93115799
2ERN13.12250112
3TRIB32.91587874
4MAP4K12.64776131
5TTN2.54151670
6EEF2K2.53726405
7MAP2K32.44342272
8RIPK12.36193114
9SMG12.27788988
10OBSCN2.21865775
11MAP3K101.99599729
12TYK21.96955580
13TBK11.93824498
14ICK1.93541199
15FGFR41.82425131
16MAP3K131.72547215
17MAP3K141.69728575
18FGR1.65009102
19BLK1.63619403
20JAK31.60893694
21MAP3K11.53059375
22MAP3K31.44998282
23EPHB11.41934994
24RIPK41.40525651
25IRAK31.35316288
26MAPK121.32797405
27TAOK21.32696950
28FES1.31295421
29MAP3K111.25899233
30CSK1.22354071
31PDK21.20797815
32CDC42BPA1.20586717
33KSR21.18546553
34MAP3K71.11306455
35IRAK41.10713274
36MATK1.08631718
37DDR21.06497213
38PINK11.05234321
39SIK11.02228814
40CSF1R1.01266242
41JAK10.98251125
42TGFBR20.97305307
43ZAP700.95952373
44MAPK110.95036235
45TESK20.93117302
46CDK120.91135683
47TAOK10.90247214
48KDR0.90173665
49MARK30.88242317
50NME20.85445622
51MARK20.84661439
52NEK90.84578065
53RPS6KA20.83660631
54PDPK10.83035464
55PRKD20.82532025
56PDGFRA0.82351796
57BTK0.82156262
58RPS6KC10.80940976
59RPS6KL10.80940976
60PTK60.79108797
61CDK40.78870464
62JAK20.78197427
63MTOR0.78100619
64IKBKE0.72462003
65BMX0.71472011
66SIK20.70673782
67IKBKB0.67528125
68DYRK1B0.67447083
69EPHA30.67184107
70FGFR30.65801368
71HCK0.65311255
72MAPK70.65268977
73GRK60.65173838
74SYK0.62948547
75PAK40.62551102
76RPS6KA10.59034691
77MOS0.56931458
78MAPK40.56519089
79PDK10.55882385
80RPS6KA60.55715876
81PKN20.55678276
82LYN0.52502876
83CDK60.51972372
84PIM10.50272059
85MAP2K20.49482393
86PRKG20.49228067
87KIT0.47689471
88PRKAA20.47507535
89EPHB20.47497703
90AKT20.43571268
91MAP3K80.42227721
92ARAF0.41481189
93CCNB10.39675510
94MAPKAPK30.39665342
95CDK90.38182801
96LCK0.37999872
97TIE10.36569136
98PIM20.36443532
99SGK30.36163914
100MAP3K60.34967554

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.94596237
2Staphylococcus aureus infection_Homo sapiens_hsa051502.50307245
3Osteoclast differentiation_Homo sapiens_hsa043802.16648491
4Leishmaniasis_Homo sapiens_hsa051402.12563452
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.03675591
6B cell receptor signaling pathway_Homo sapiens_hsa046621.95195096
7Toll-like receptor signaling pathway_Homo sapiens_hsa046201.75280874
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.74554748
9Allograft rejection_Homo sapiens_hsa053301.68099609
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.63669985
11Tuberculosis_Homo sapiens_hsa051521.57637470
12Viral myocarditis_Homo sapiens_hsa054161.56775933
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.53784405
14Acute myeloid leukemia_Homo sapiens_hsa052211.49512728
15Pertussis_Homo sapiens_hsa051331.48736869
16Autoimmune thyroid disease_Homo sapiens_hsa053201.46981350
17Fructose and mannose metabolism_Homo sapiens_hsa000511.45242075
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.44915722
19Galactose metabolism_Homo sapiens_hsa000521.40477123
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39382656
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.38550782
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.37084279
23Arginine biosynthesis_Homo sapiens_hsa002201.35832654
24Toxoplasmosis_Homo sapiens_hsa051451.35723480
25Lysosome_Homo sapiens_hsa041421.33586363
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.31892461
27Influenza A_Homo sapiens_hsa051641.31799880
28TNF signaling pathway_Homo sapiens_hsa046681.25973956
29Asthma_Homo sapiens_hsa053101.20714040
30Complement and coagulation cascades_Homo sapiens_hsa046101.20528943
31Pentose phosphate pathway_Homo sapiens_hsa000301.20128218
32Graft-versus-host disease_Homo sapiens_hsa053321.18746512
33Hepatitis C_Homo sapiens_hsa051601.12263090
34Herpes simplex infection_Homo sapiens_hsa051681.11495861
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.11240301
36Apoptosis_Homo sapiens_hsa042101.07450696
37PPAR signaling pathway_Homo sapiens_hsa033201.06961977
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.00921491
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00410839
40Phagosome_Homo sapiens_hsa041451.00163978
41Hepatitis B_Homo sapiens_hsa051610.98608462
42Measles_Homo sapiens_hsa051620.97762791
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96856259
44Adipocytokine signaling pathway_Homo sapiens_hsa049200.96760519
45Malaria_Homo sapiens_hsa051440.95294062
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94780951
47Prion diseases_Homo sapiens_hsa050200.94303997
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94228973
49Insulin resistance_Homo sapiens_hsa049310.93503233
50Chronic myeloid leukemia_Homo sapiens_hsa052200.93180299
51Notch signaling pathway_Homo sapiens_hsa043300.92925943
52Phenylalanine metabolism_Homo sapiens_hsa003600.90107121
53Primary immunodeficiency_Homo sapiens_hsa053400.85588660
54Central carbon metabolism in cancer_Homo sapiens_hsa052300.84431583
55Biosynthesis of amino acids_Homo sapiens_hsa012300.83815205
56Jak-STAT signaling pathway_Homo sapiens_hsa046300.82130305
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.81839411
58Rheumatoid arthritis_Homo sapiens_hsa053230.81497654
59Insulin signaling pathway_Homo sapiens_hsa049100.80533093
60Type I diabetes mellitus_Homo sapiens_hsa049400.80373180
61Salmonella infection_Homo sapiens_hsa051320.79755956
62Amoebiasis_Homo sapiens_hsa051460.79452334
63Bladder cancer_Homo sapiens_hsa052190.77187605
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73839231
65Antigen processing and presentation_Homo sapiens_hsa046120.73633324
66Platelet activation_Homo sapiens_hsa046110.73363704
67Hematopoietic cell lineage_Homo sapiens_hsa046400.71829421
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71504718
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70937455
70Chemokine signaling pathway_Homo sapiens_hsa040620.70889253
71T cell receptor signaling pathway_Homo sapiens_hsa046600.69868165
72Pancreatic cancer_Homo sapiens_hsa052120.69800253
73Legionellosis_Homo sapiens_hsa051340.68407632
74Shigellosis_Homo sapiens_hsa051310.67796348
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.67724549
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66181567
77Endometrial cancer_Homo sapiens_hsa052130.65394111
78AMPK signaling pathway_Homo sapiens_hsa041520.64323627
79Non-small cell lung cancer_Homo sapiens_hsa052230.63357201
80Carbon metabolism_Homo sapiens_hsa012000.63352992
81Prolactin signaling pathway_Homo sapiens_hsa049170.60764322
82Systemic lupus erythematosus_Homo sapiens_hsa053220.60693182
83Sulfur relay system_Homo sapiens_hsa041220.58530664
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58469893
85GnRH signaling pathway_Homo sapiens_hsa049120.58338437
86VEGF signaling pathway_Homo sapiens_hsa043700.58312494
87Fatty acid degradation_Homo sapiens_hsa000710.56182866
88Viral carcinogenesis_Homo sapiens_hsa052030.55495136
89HTLV-I infection_Homo sapiens_hsa051660.52993727
90Vitamin digestion and absorption_Homo sapiens_hsa049770.52207954
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52008378
92Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51843279
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48131311
94Focal adhesion_Homo sapiens_hsa045100.47885566
95Renal cell carcinoma_Homo sapiens_hsa052110.45408793
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.45310529
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44210844
98HIF-1 signaling pathway_Homo sapiens_hsa040660.42808351
99mTOR signaling pathway_Homo sapiens_hsa041500.42745433
100Prostate cancer_Homo sapiens_hsa052150.42420748

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »