ZBED2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of isotype switching to IgG isotypes (GO:0048302)6.45694869
2regulation of interleukin-2 biosynthetic process (GO:0045076)6.45202288
3positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.33493448
4cellular response to interleukin-15 (GO:0071350)6.28872087
5response to interleukin-15 (GO:0070672)6.03868907
6negative T cell selection (GO:0043383)5.76676003
7tolerance induction (GO:0002507)5.70756451
8regulation of chronic inflammatory response (GO:0002676)5.36767481
9negative thymic T cell selection (GO:0045060)5.15296150
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.09517421
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.83196063
12regulation of regulatory T cell differentiation (GO:0045589)4.67886357
13CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.66102499
14positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.65987635
15negative regulation of interleukin-2 production (GO:0032703)4.64367206
16NIK/NF-kappaB signaling (GO:0038061)4.61753414
17activated T cell proliferation (GO:0050798)4.60999831
18positive regulation of natural killer cell mediated immunity (GO:0002717)4.53782980
19negative regulation of T cell mediated immunity (GO:0002710)4.53226461
20thymic T cell selection (GO:0045061)4.51908365
21positive regulation of granulocyte differentiation (GO:0030854)4.50760682
22positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.44485335
23regulation of histone H3-K27 methylation (GO:0061085)4.44275005
24interferon-gamma production (GO:0032609)4.29566325
25positive regulation of inflammatory response to antigenic stimulus (GO:0002863)4.28311314
26regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.27067805
27regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.19636172
28positive regulation of immunoglobulin production (GO:0002639)4.08975057
29regulation of T cell tolerance induction (GO:0002664)4.08072148
30positive regulation of tolerance induction (GO:0002645)4.07005421
31regulation of immunoglobulin production (GO:0002637)4.03521069
32regulation of gamma-delta T cell differentiation (GO:0045586)3.99077876
33T cell selection (GO:0045058)3.95817968
34regulation of vitamin D biosynthetic process (GO:0060556)3.95391484
35regulation of transforming growth factor beta1 production (GO:0032908)3.89352649
36positive regulation of alpha-beta T cell proliferation (GO:0046641)3.84914270
37antigen processing and presentation of endogenous antigen (GO:0019883)3.83151745
38regulation of interleukin-2 production (GO:0032663)3.82451907
39regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.79666117
40regulation of natural killer cell mediated immunity (GO:0002715)3.79666117
41regulation of lymphocyte chemotaxis (GO:1901623)3.78433950
42myeloid dendritic cell differentiation (GO:0043011)3.77682182
43positive regulation of macrophage activation (GO:0043032)3.75479419
44regulation of alpha-beta T cell proliferation (GO:0046640)3.70895347
45positive T cell selection (GO:0043368)3.67835193
46regulation of isotype switching (GO:0045191)3.67659307
47positive regulation of keratinocyte differentiation (GO:0045618)3.66154137
48JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.64960864
49positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.63415609
50cellular response to interleukin-4 (GO:0071353)3.62683435
51regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.60706126
52positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.60706126
53positive regulation of gamma-delta T cell activation (GO:0046645)3.58770493
54hemidesmosome assembly (GO:0031581)3.57351878
55tyrosine phosphorylation of STAT protein (GO:0007260)3.50891832
56positive regulation of interleukin-2 production (GO:0032743)3.47806351
57positive regulation of B cell mediated immunity (GO:0002714)3.47461546
58positive regulation of immunoglobulin mediated immune response (GO:0002891)3.47461546
59T cell apoptotic process (GO:0070231)3.47272402
60positive regulation of humoral immune response (GO:0002922)3.46876074
61DNA deamination (GO:0045006)3.44509852
62T cell homeostasis (GO:0043029)3.43233444
63positive regulation of cell killing (GO:0031343)3.42757579
64alpha-beta T cell differentiation (GO:0046632)3.41049918
65positive regulation of interleukin-4 production (GO:0032753)3.40378223
66folic acid-containing compound biosynthetic process (GO:0009396)3.40089701
67myeloid dendritic cell activation (GO:0001773)3.39921773
68regulation of interleukin-5 production (GO:0032674)3.36390652
69necroptotic process (GO:0070266)3.35459304
70regulation of T cell chemotaxis (GO:0010819)3.31951793
71positive regulation of T cell chemotaxis (GO:0010820)3.31951793
72T cell lineage commitment (GO:0002360)3.31268609
73regulation of immunoglobulin secretion (GO:0051023)3.30534165
74CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.29650737
75positive regulation of isotype switching (GO:0045830)3.27985748
76regulation of RIG-I signaling pathway (GO:0039535)3.26779559
77positive thymic T cell selection (GO:0045059)3.26320877
78regulation of immunoglobulin mediated immune response (GO:0002889)3.20459888
79CD4-positive, alpha-beta T cell activation (GO:0035710)3.19604230
80positive regulation of lymphocyte mediated immunity (GO:0002708)3.19089178
81regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.17671610
82regulation of gamma-delta T cell activation (GO:0046643)3.16831904
83T cell proliferation (GO:0042098)3.16772987
84regulation of tolerance induction (GO:0002643)3.15899378
85alpha-beta T cell activation (GO:0046631)3.14032717
86regulation of leukocyte mediated cytotoxicity (GO:0001910)3.11009174
87response to interleukin-4 (GO:0070670)3.09957868
88regulation of B cell mediated immunity (GO:0002712)3.06434227
89type I interferon signaling pathway (GO:0060337)3.04788774
90cellular response to type I interferon (GO:0071357)3.04788774
91lymphocyte apoptotic process (GO:0070227)3.04590395
92regulation of translational termination (GO:0006449)3.03419919
93response to type I interferon (GO:0034340)3.02680018
94regulation of transforming growth factor beta production (GO:0071634)2.99338699
95regulation of vitamin metabolic process (GO:0030656)2.97112013
96negative regulation of interleukin-12 production (GO:0032695)2.95245198
97alpha-beta T cell differentiation involved in immune response (GO:0002293)2.94403273
98alpha-beta T cell activation involved in immune response (GO:0002287)2.94403273
99T cell differentiation involved in immune response (GO:0002292)2.94403273
100regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.94111027

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.63810187
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.37121816
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.48751582
4E2F7_22180533_ChIP-Seq_HELA_Human5.20187419
5TP63_17297297_ChIP-ChIP_HaCaT_Human4.10559705
6STAT4_19710469_ChIP-ChIP_TH1__Mouse3.31221691
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.01331122
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.89734612
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.73931592
10* MYB_26560356_Chip-Seq_TH2_Human2.72276912
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.67507190
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.58639662
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.45600889
14MAF_26560356_Chip-Seq_TH1_Human2.42132012
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.36193192
16MYC_22102868_ChIP-Seq_BL_Human2.35808116
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.28716832
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.23622453
19MYB_26560356_Chip-Seq_TH1_Human2.19723577
20MAF_26560356_Chip-Seq_TH2_Human2.11064972
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.03674569
22EGR1_19374776_ChIP-ChIP_THP-1_Human1.98926067
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.82830298
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.78740959
25RUNX_20019798_ChIP-Seq_JUKART_Human1.76427188
26E2F4_17652178_ChIP-ChIP_JURKAT_Human1.72255071
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.70730199
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.68321359
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.68222583
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.67122235
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.63780267
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.63539533
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61393230
34MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.61023463
35JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60149273
36IRF8_21731497_ChIP-ChIP_J774_Mouse1.59635163
37VDR_23849224_ChIP-Seq_CD4+_Human1.57690009
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.52176371
39FOXP3_21729870_ChIP-Seq_TREG_Human1.47882189
40CREB1_15753290_ChIP-ChIP_HEK293T_Human1.46596861
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.45707917
42UTX_26944678_Chip-Seq_JUKART_Human1.45599252
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.45106985
44MYC_19030024_ChIP-ChIP_MESCs_Mouse1.41897953
45GATA3_27048872_Chip-Seq_THYMUS_Human1.34184222
46HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29807609
47KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.29315931
48ETS1_20019798_ChIP-Seq_JURKAT_Human1.28158602
49DCP1A_22483619_ChIP-Seq_HELA_Human1.26760948
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22025710
51MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21989792
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21440086
53SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21344522
54GATA3_26560356_Chip-Seq_TH2_Human1.20559163
55SPI1_23547873_ChIP-Seq_NB4_Human1.19983740
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17298697
57RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09114295
58VDR_21846776_ChIP-Seq_THP-1_Human1.07932130
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06698924
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04860531
61CIITA_25753668_ChIP-Seq_RAJI_Human1.04409218
62TCF7_22412390_ChIP-Seq_EML_Mouse1.00397470
63GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99367336
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98998156
65SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98882520
66ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98682485
67NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97871763
68KDM5A_27292631_Chip-Seq_BREAST_Human0.97532247
69RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.97448296
70XRN2_22483619_ChIP-Seq_HELA_Human0.95471433
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95067012
72CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.95043945
73RUNX1_22412390_ChIP-Seq_EML_Mouse0.92451000
74GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89564952
75GABP_19822575_ChIP-Seq_HepG2_Human0.88390861
76GATA1_22025678_ChIP-Seq_K562_Human0.88374645
77NELFA_20434984_ChIP-Seq_ESCs_Mouse0.88276070
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87991324
79STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86970174
80BRD4_27068464_Chip-Seq_AML-cells_Mouse0.86936592
81KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.86678733
82CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84062176
83YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.83464441
84HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83071402
85FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.82450206
86THAP11_20581084_ChIP-Seq_MESCs_Mouse0.81705160
87MYCN_18555785_ChIP-Seq_MESCs_Mouse0.79853956
88SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.79378289
89YY1_21170310_ChIP-Seq_MESCs_Mouse0.77869326
90CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.76418926
91PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74604027
92SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73534497
93KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.72812274
94IRF8_27001747_Chip-Seq_BMDM_Mouse0.72698759
95TTF2_22483619_ChIP-Seq_HELA_Human0.72409961
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72403886
97ELF5_23300383_ChIP-Seq_T47D_Human0.72134186
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.71769909
99ATF3_27146783_Chip-Seq_COLON_Human0.71336808
100E2F1_21310950_ChIP-Seq_MCF-7_Human0.71282226

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology5.10453512
2MP0009333_abnormal_splenocyte_physiolog4.33603162
3MP0001873_stomach_inflammation4.03677826
4MP0005671_abnormal_response_to3.88338832
5MP0001835_abnormal_antigen_presentation3.52781467
6MP0001790_abnormal_immune_system3.27064117
7MP0005387_immune_system_phenotype3.27064117
8MP0002006_tumorigenesis3.02597190
9MP0002166_altered_tumor_susceptibility2.89260963
10MP0003436_decreased_susceptibility_to2.88090967
11MP0001800_abnormal_humoral_immune2.70443179
12MP0003300_gastrointestinal_ulcer2.69826359
13MP0005000_abnormal_immune_tolerance2.64818034
14MP0008057_abnormal_DNA_replication2.63724628
15MP0003866_abnormal_defecation2.44183615
16MP0009785_altered_susceptibility_to2.40525215
17MP0000703_abnormal_thymus_morphology2.28671039
18MP0003045_fibrosis2.28102933
19MP0000685_abnormal_immune_system2.24879931
20MP0005310_abnormal_salivary_gland2.23616769
21MP0002723_abnormal_immune_serum2.20694092
22MP0002398_abnormal_bone_marrow2.18035736
23MP0002420_abnormal_adaptive_immunity2.14544035
24MP0004381_abnormal_hair_follicle2.12080346
25MP0004947_skin_inflammation2.09175291
26MP0001819_abnormal_immune_cell2.07109140
27MP0002877_abnormal_melanocyte_morpholog2.02619277
28MP0002405_respiratory_system_inflammati1.99962612
29MP0002452_abnormal_antigen_presenting1.96050090
30MP0005025_abnormal_response_to1.88176106
31MP0000716_abnormal_immune_system1.87865053
32MP0002148_abnormal_hypersensitivity_rea1.79357761
33MP0010155_abnormal_intestine_physiology1.77775278
34MP0003693_abnormal_embryo_hatching1.76802723
35MP0001853_heart_inflammation1.66321167
36MP0002722_abnormal_immune_system1.63271358
37MP0002138_abnormal_hepatobiliary_system1.63261228
38MP0002429_abnormal_blood_cell1.60974567
39MP0000689_abnormal_spleen_morphology1.53667100
40MP0002396_abnormal_hematopoietic_system1.52479973
41MP0001845_abnormal_inflammatory_respons1.46566471
42MP0005451_abnormal_body_composition1.36790799
43MP0004957_abnormal_blastocyst_morpholog1.34396688
44MP0001216_abnormal_epidermal_layer1.33236993
45MP0001727_abnormal_embryo_implantation1.29321750
46MP0004510_myositis1.29094181
47MP0001851_eye_inflammation1.23380516
48MP0000490_abnormal_crypts_of1.22381337
49MP0003453_abnormal_keratinocyte_physiol1.21182730
50MP0003448_altered_tumor_morphology1.17485993
51MP0001348_abnormal_lacrimal_gland1.13813758
52MP0010234_abnormal_vibrissa_follicle1.12437336
53MP0002796_impaired_skin_barrier1.10119699
54MP0010094_abnormal_chromosome_stability1.08603359
55MP0002419_abnormal_innate_immunity1.08455808
56MP0004808_abnormal_hematopoietic_stem1.07940295
57MP0003111_abnormal_nucleus_morphology1.04588663
58MP0000569_abnormal_digit_pigmentation1.02817662
59MP0004185_abnormal_adipocyte_glucose1.00778656
60MP0002019_abnormal_tumor_incidence0.98120110
61MP0002163_abnormal_gland_morphology0.98043643
62MP0003077_abnormal_cell_cycle0.97360246
63MP0003315_abnormal_perineum_morphology0.95768026
64MP0002277_abnormal_respiratory_mucosa0.94034740
65MP0010352_gastrointestinal_tract_polyps0.93369916
66MP0003303_peritoneal_inflammation0.92976762
67MP0003786_premature_aging0.90463744
68MP0008058_abnormal_DNA_repair0.88047409
69MP0008469_abnormal_protein_level0.86607260
70MP0006082_CNS_inflammation0.84680334
71MP0001533_abnormal_skeleton_physiology0.79995178
72MP0002060_abnormal_skin_morphology0.78534932
73MP0000579_abnormal_nail_morphology0.75272515
74MP0001881_abnormal_mammary_gland0.75247413
75MP0009763_increased_sensitivity_to0.73338864
76MP0005166_decreased_susceptibility_to0.72568129
77MP0000627_abnormal_mammary_gland0.72062563
78MP0001663_abnormal_digestive_system0.72052930
79MP0000858_altered_metastatic_potential0.71604371
80MP0005501_abnormal_skin_physiology0.71210956
81MP0008007_abnormal_cellular_replicative0.70357491
82MP0000350_abnormal_cell_proliferation0.69475837
83MP0002933_joint_inflammation0.68043675
84MP0005075_abnormal_melanosome_morpholog0.67063015
85MP0000371_diluted_coat_color0.65837722
86MP0001501_abnormal_sleep_pattern0.65815978
87MP0000367_abnormal_coat/_hair0.65108047
88MP0009931_abnormal_skin_appearance0.64225696
89MP0000477_abnormal_intestine_morphology0.62614542
90MP0004264_abnormal_extraembryonic_tissu0.62371021
91MP0001919_abnormal_reproductive_system0.61190423
92MP0005023_abnormal_wound_healing0.60299131
93MP0005464_abnormal_platelet_physiology0.60057849
94MP0000465_gastrointestinal_hemorrhage0.59317243
95MP0001958_emphysema0.59191186
96MP0005076_abnormal_cell_differentiation0.58552807
97MP0002168_other_aberrant_phenotype0.58069398
98MP0002254_reproductive_system_inflammat0.57262892
99MP0005379_endocrine/exocrine_gland_phen0.55807829
100MP0009765_abnormal_xenobiotic_induced0.54128970

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.43324323
2Abnormality of T cell number (HP:0011839)5.92175848
3Autoimmune hemolytic anemia (HP:0001890)5.53199422
4Chronic diarrhea (HP:0002028)5.06925461
5Abnormality of T cells (HP:0002843)4.95087279
6Milia (HP:0001056)4.78665696
7Abnormal delayed hypersensitivity skin test (HP:0002963)4.42414532
8Retrobulbar optic neuritis (HP:0100654)4.39486788
9Optic neuritis (HP:0100653)4.39486788
10Recurrent viral infections (HP:0004429)4.36217768
11Onycholysis (HP:0001806)4.07201450
12Myositis (HP:0100614)3.97242494
13Elevated erythrocyte sedimentation rate (HP:0003565)3.95353274
14Keratoconjunctivitis sicca (HP:0001097)3.86290523
15IgA deficiency (HP:0002720)3.85348417
16Abnormality of T cell physiology (HP:0011840)3.81840466
17Orchitis (HP:0100796)3.78741796
18Pulmonary infiltrates (HP:0002113)3.69509598
19IgM deficiency (HP:0002850)3.64012019
20Recurrent fungal infections (HP:0002841)3.59016455
21Stomatitis (HP:0010280)3.53310790
22Keratoconjunctivitis (HP:0001096)3.47819049
23Oral leukoplakia (HP:0002745)3.34365931
24Duplicated collecting system (HP:0000081)3.26341620
25Fragile nails (HP:0001808)3.25662628
26Encephalitis (HP:0002383)3.18130110
27Upper limb muscle weakness (HP:0003484)3.15587353
28Plantar hyperkeratosis (HP:0007556)3.15047044
29Increased IgM level (HP:0003496)3.13625270
30Recurrent bronchitis (HP:0002837)3.10282283
31IgG deficiency (HP:0004315)2.95879140
32Joint swelling (HP:0001386)2.94924632
33Severe combined immunodeficiency (HP:0004430)2.94743707
34Aplastic anemia (HP:0001915)2.94236734
35Abnormal blistering of the skin (HP:0008066)2.87828754
36Granulocytopenia (HP:0001913)2.85053391
37Peripheral hypomyelination (HP:0007182)2.83848297
38Nail dystrophy (HP:0008404)2.79641752
39Vasculitis (HP:0002633)2.78560961
40Abnormality of nail color (HP:0100643)2.76627292
41Gangrene (HP:0100758)2.75757710
42Pustule (HP:0200039)2.74696387
43Abnormality of the renal collecting system (HP:0004742)2.74259182
44Recurrent cutaneous fungal infections (HP:0011370)2.73642480
45Chronic mucocutaneous candidiasis (HP:0002728)2.73642480
46Eosinophilia (HP:0001880)2.64136160
47Nasal polyposis (HP:0100582)2.63294975
48B lymphocytopenia (HP:0010976)2.62664373
49Increased IgE level (HP:0003212)2.61362300
50Thick nail (HP:0001805)2.60870992
51Abnormality of eosinophils (HP:0001879)2.56857795
52Ureteral stenosis (HP:0000071)2.55241156
53Lymphoma (HP:0002665)2.54316947
54Ridged nail (HP:0001807)2.51837558
55Gastrointestinal infarctions (HP:0005244)2.49781836
56Chronic otitis media (HP:0000389)2.47367460
57Panhypogammaglobulinemia (HP:0003139)2.46642939
58Rough bone trabeculation (HP:0100670)2.41545211
59Hemoptysis (HP:0002105)2.40499583
60Combined immunodeficiency (HP:0005387)2.40239807
61Meningitis (HP:0001287)2.39898500
62Keratitis (HP:0000491)2.38810174
63Ureteral obstruction (HP:0006000)2.36895510
64Abnormality of B cell number (HP:0010975)2.34872049
65Villous atrophy (HP:0011473)2.30944228
66Abnormality of small intestinal villus morphology (HP:0011472)2.30944228
67Ileus (HP:0002595)2.24961265
68Abnormality of cells of the lymphoid lineage (HP:0012140)2.23880222
69Lymphopenia (HP:0001888)2.15738243
70Hypergammaglobulinemia (HP:0010702)2.14918693
71Acute hepatic failure (HP:0006554)2.13344242
72Arterial thrombosis (HP:0004420)2.12979729
73Abnormality of the fingertips (HP:0001211)2.12879182
74Anhidrosis (HP:0000970)2.03475865
75Selective tooth agenesis (HP:0001592)2.01236572
76Poikiloderma (HP:0001029)2.00584159
77Atrophic scars (HP:0001075)1.98867028
78Reduced subcutaneous adipose tissue (HP:0003758)1.98430491
79Abnormality of oral frenula (HP:0000190)1.98065932
80Glomerulopathy (HP:0100820)1.97627422
81Abnormality of the nasal mucosa (HP:0000433)1.97336194
82Ureteral duplication (HP:0000073)1.94857246
83Palmoplantar hyperkeratosis (HP:0000972)1.94617567
84Pulmonary embolism (HP:0002204)1.91522915
85Premature graying of hair (HP:0002216)1.91055646
86Hypoplasia of the thymus (HP:0000778)1.90964728
87Abnormality of the preputium (HP:0100587)1.89963633
88Sparse scalp hair (HP:0002209)1.89158009
89Skin ulcer (HP:0200042)1.88437843
90Alopecia of scalp (HP:0002293)1.87050893
91Pancytopenia (HP:0001876)1.86367485
92Abnormal trabecular bone morphology (HP:0100671)1.86262269
93Mediastinal lymphadenopathy (HP:0100721)1.84235739
94Abnormality of DNA repair (HP:0003254)1.82903134
95Generalized hypopigmentation of hair (HP:0011358)1.82018159
96Gastrointestinal dysmotility (HP:0002579)1.81427960
97Palmar hyperkeratosis (HP:0010765)1.80353329
98Prominent nose (HP:0000448)1.79922466
99Erythema (HP:0010783)1.79514380
100Interstitial pulmonary disease (HP:0006530)1.77881656

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.57105700
2MAP4K14.59520942
3FGFR43.76396773
4TSSK63.24184813
5MAP3K133.09657130
6PRPF4B3.06674711
7MAP3K142.97101566
8ITK2.61004823
9JAK32.53537736
10MST42.40140382
11EPHA32.28667574
12SMG12.03454316
13TAOK21.94049214
14FGFR31.84180758
15JAK11.76537143
16NME11.64266196
17EIF2AK11.61208461
18EPHB11.59254861
19IKBKE1.57820815
20TYK21.56146739
21NLK1.55989990
22CDK121.47919700
23SCYL21.47737114
24BUB11.43737424
25MAP3K91.43350035
26NME21.41661080
27LCK1.37592281
28SRPK11.37207501
29STK241.31056971
30MAPK111.29070675
31EIF2AK31.25515095
32ALK1.25443661
33PASK1.22541973
34FES1.16276071
35MAP3K121.15808665
36PRKCQ1.12485584
37ZAP701.10848665
38IKBKB1.08898863
39TRIB31.06872949
40BTK1.06425546
41ARAF1.04709251
42IRAK11.04327234
43CLK11.01005230
44WNK10.90169115
45MAP3K70.90159538
46KDR0.81464479
47IRAK30.79434245
48CAMKK20.78917811
49NEK10.78350873
50MAP3K80.77504156
51MAP3K30.75936373
52RIPK40.74988194
53CSK0.74226698
54TYRO30.73798622
55MAP2K60.68636321
56MAP3K10.67850587
57HIPK20.67608878
58JAK20.67555988
59SYK0.64921773
60CHUK0.63855143
61RPS6KA40.63269635
62TAF10.62985068
63EIF2AK20.62580460
64RPS6KA50.61549813
65SIK30.61223836
66MAP3K110.60914357
67STK100.60436101
68NEK90.59855967
69WNK40.58554664
70TAOK30.58083290
71TBK10.57934230
72HCK0.57877013
73CDK40.57082854
74PIK3CG0.56409823
75ILK0.54978340
76MST1R0.53188520
77VRK20.52357403
78TAOK10.50675651
79CDK70.46573383
80TEC0.45418682
81PKN20.44683432
82CHEK10.43992384
83CDK80.43588930
84STK390.42006171
85CDC70.41257196
86NTRK10.41111074
87PDGFRB0.39624844
88RAF10.39523919
89BRD40.39197854
90DAPK10.36840605
91CAMKK10.34876419
92PRKCH0.34486175
93MAP2K30.34300426
94RET0.33519296
95FGFR10.33012030
96ATR0.32517292
97TRPM70.31790387
98IRAK40.30702230
99SIK10.30689912
100NUAK10.27625243

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.88049644
2T cell receptor signaling pathway_Homo sapiens_hsa046603.59712338
3Measles_Homo sapiens_hsa051623.19590471
4Autoimmune thyroid disease_Homo sapiens_hsa053203.02229021
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.88340773
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.83719335
7Allograft rejection_Homo sapiens_hsa053302.78043859
8Proteasome_Homo sapiens_hsa030502.74740120
9Jak-STAT signaling pathway_Homo sapiens_hsa046302.58532075
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.41535163
11Graft-versus-host disease_Homo sapiens_hsa053322.41021590
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.33668789
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.24719756
14Type I diabetes mellitus_Homo sapiens_hsa049402.11775864
15One carbon pool by folate_Homo sapiens_hsa006701.96545381
16Antigen processing and presentation_Homo sapiens_hsa046121.94286535
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.85037411
18DNA replication_Homo sapiens_hsa030301.81385148
19Asthma_Homo sapiens_hsa053101.80016319
20Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.77325802
21Hematopoietic cell lineage_Homo sapiens_hsa046401.64046992
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.61871342
23Spliceosome_Homo sapiens_hsa030401.59001357
24TNF signaling pathway_Homo sapiens_hsa046681.52161462
25Herpes simplex infection_Homo sapiens_hsa051681.50227562
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.47735601
27Hepatitis B_Homo sapiens_hsa051611.39574623
28Acute myeloid leukemia_Homo sapiens_hsa052211.35474502
29Prolactin signaling pathway_Homo sapiens_hsa049171.35386913
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.27171914
31Apoptosis_Homo sapiens_hsa042101.27141409
32RNA polymerase_Homo sapiens_hsa030201.24172118
33Epstein-Barr virus infection_Homo sapiens_hsa051691.15461843
34Nucleotide excision repair_Homo sapiens_hsa034201.14811612
35B cell receptor signaling pathway_Homo sapiens_hsa046621.13864871
36HTLV-I infection_Homo sapiens_hsa051661.12722145
37Mismatch repair_Homo sapiens_hsa034301.12101895
38Pancreatic cancer_Homo sapiens_hsa052121.11150031
39Toxoplasmosis_Homo sapiens_hsa051451.08052621
40VEGF signaling pathway_Homo sapiens_hsa043701.06458560
41Influenza A_Homo sapiens_hsa051641.06291660
42RNA transport_Homo sapiens_hsa030131.03059673
43Viral carcinogenesis_Homo sapiens_hsa052030.99969214
44Shigellosis_Homo sapiens_hsa051310.99395028
45NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97421518
46Small cell lung cancer_Homo sapiens_hsa052220.95925748
47Chronic myeloid leukemia_Homo sapiens_hsa052200.94562094
48Osteoclast differentiation_Homo sapiens_hsa043800.92868868
49Pyrimidine metabolism_Homo sapiens_hsa002400.92760377
50mRNA surveillance pathway_Homo sapiens_hsa030150.87355277
51Chemokine signaling pathway_Homo sapiens_hsa040620.86244909
52Non-small cell lung cancer_Homo sapiens_hsa052230.85358302
53Viral myocarditis_Homo sapiens_hsa054160.83219006
54Non-homologous end-joining_Homo sapiens_hsa034500.78794818
55Hepatitis C_Homo sapiens_hsa051600.78195864
56Salmonella infection_Homo sapiens_hsa051320.76825208
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.74254420
58Protein export_Homo sapiens_hsa030600.71312843
59Ribosome_Homo sapiens_hsa030100.71031291
60Thyroid cancer_Homo sapiens_hsa052160.70840687
61RNA degradation_Homo sapiens_hsa030180.69970502
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65589873
63Cell cycle_Homo sapiens_hsa041100.63634411
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63163546
65Intestinal immune network for IgA production_Homo sapiens_hsa046720.60547566
66Base excision repair_Homo sapiens_hsa034100.58242770
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.57516642
68Fructose and mannose metabolism_Homo sapiens_hsa000510.56816600
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51130645
70Sulfur metabolism_Homo sapiens_hsa009200.51064296
71Legionellosis_Homo sapiens_hsa051340.50726881
72MicroRNAs in cancer_Homo sapiens_hsa052060.48630086
73p53 signaling pathway_Homo sapiens_hsa041150.47262882
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46974912
75Prion diseases_Homo sapiens_hsa050200.46815831
76Renal cell carcinoma_Homo sapiens_hsa052110.45297661
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42141097
78Insulin resistance_Homo sapiens_hsa049310.39969571
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39420565
80Homologous recombination_Homo sapiens_hsa034400.37938884
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37800739
82MAPK signaling pathway_Homo sapiens_hsa040100.37356952
83Biosynthesis of amino acids_Homo sapiens_hsa012300.36611924
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36100465
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33376687
86Prostate cancer_Homo sapiens_hsa052150.33033859
87mTOR signaling pathway_Homo sapiens_hsa041500.31393523
88HIF-1 signaling pathway_Homo sapiens_hsa040660.30430664
89Colorectal cancer_Homo sapiens_hsa052100.30328750
90Fanconi anemia pathway_Homo sapiens_hsa034600.29054698
91Leishmaniasis_Homo sapiens_hsa051400.28152705
92Purine metabolism_Homo sapiens_hsa002300.27987152
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26252909
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.25774943
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23778955
96Endocytosis_Homo sapiens_hsa041440.22770200
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.22761356
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20710370
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.20235932
100N-Glycan biosynthesis_Homo sapiens_hsa005100.20085099

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