ZBED3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to a class of genes that arose through hAT DNA transposition and that encode regulatory proteins. This gene is upregulated in lung cancer tissues, where the encoded protein causes an accumulation of beta-catenin and enhanced lung cancer cell invasion. In addition, the encoded protein can be secreted and be involved in resistance to insulin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)7.43317347
2female gamete generation (GO:0007292)6.46254605
3negative regulation of retinoic acid receptor signaling pathway (GO:0048387)6.40492893
4regulation of meiosis (GO:0040020)6.18728139
5mitotic chromosome condensation (GO:0007076)6.15166052
6meiotic cell cycle (GO:0051321)5.82348429
7regulation of female gonad development (GO:2000194)5.65959859
8mitotic metaphase plate congression (GO:0007080)5.56596435
9regulation of meiosis I (GO:0060631)5.43199100
10histone H2A monoubiquitination (GO:0035518)5.23927068
11regulation of sister chromatid cohesion (GO:0007063)5.16769423
12regulation of exit from mitosis (GO:0007096)5.14272853
13DNA damage induced protein phosphorylation (GO:0006975)5.06724321
14oocyte maturation (GO:0001556)5.01501451
15negative regulation of hormone biosynthetic process (GO:0032353)4.98757848
16negative regulation of hormone metabolic process (GO:0032351)4.98757848
17regulation of retinoic acid receptor signaling pathway (GO:0048385)4.97134000
18negative regulation of meiosis (GO:0045835)4.96570744
19regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.94393388
20mitotic sister chromatid segregation (GO:0000070)4.93155372
21female gonad development (GO:0008585)4.86601065
22metaphase plate congression (GO:0051310)4.86081324
23establishment of chromosome localization (GO:0051303)4.85359834
24regulation of meiotic cell cycle (GO:0051445)4.84296706
25glycerophospholipid catabolic process (GO:0046475)4.79992218
26DNA methylation involved in gamete generation (GO:0043046)4.75229339
27DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.75056600
28negative regulation of cytosolic calcium ion concentration (GO:0051481)4.74276447
29male meiosis (GO:0007140)4.55636040
30DNA damage response, signal transduction resulting in transcription (GO:0042772)4.51321616
31attachment of spindle microtubules to kinetochore (GO:0008608)4.50509503
32erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.48417158
33L-phenylalanine catabolic process (GO:0006559)4.48417158
34negative regulation of calcium ion-dependent exocytosis (GO:0045955)4.41527662
35negative regulation of smooth muscle cell differentiation (GO:0051151)4.32789693
36DNA methylation (GO:0006306)4.29404869
37DNA alkylation (GO:0006305)4.29404869
38histone H2A ubiquitination (GO:0033522)4.29189211
39type B pancreatic cell development (GO:0003323)4.27508412
40regulation of glycogen (starch) synthase activity (GO:2000465)4.25990663
41erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.23593150
42L-phenylalanine metabolic process (GO:0006558)4.23593150
43ether lipid metabolic process (GO:0046485)4.19740005
44regulation of RIG-I signaling pathway (GO:0039535)4.16600430
45maturation of 5.8S rRNA (GO:0000460)4.15253855
46embryonic retina morphogenesis in camera-type eye (GO:0060059)4.15120746
47regulation of histone H3-K27 methylation (GO:0061085)4.15006160
48cytoplasmic mRNA processing body assembly (GO:0033962)4.08510909
49sister chromatid segregation (GO:0000819)4.03304833
50meiotic chromosome segregation (GO:0045132)3.99979772
51negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.93813567
52negative regulation of DNA-templated transcription, elongation (GO:0032785)3.93813567
53regulation of glucocorticoid metabolic process (GO:0031943)3.93064935
54regulation of transforming growth factor beta2 production (GO:0032909)3.80187402
55negative regulation of cAMP-mediated signaling (GO:0043951)3.79114174
56gene silencing by RNA (GO:0031047)3.78572163
57interkinetic nuclear migration (GO:0022027)3.76362499
58oogenesis (GO:0048477)3.75186098
59negative regulation of circadian rhythm (GO:0042754)3.74818825
60triglyceride catabolic process (GO:0019433)3.74498328
61notochord development (GO:0030903)3.73629190
62microtubule severing (GO:0051013)3.71024116
63negative regulation of meiotic cell cycle (GO:0051447)3.70981910
64biotin metabolic process (GO:0006768)3.69870437
65snRNA transcription (GO:0009301)3.69146017
66kinetochore organization (GO:0051383)3.67347774
67monoubiquitinated protein deubiquitination (GO:0035520)3.66658286
68microtubule nucleation (GO:0007020)3.66297999
69regulation of spindle organization (GO:0090224)3.65918101
70mitotic nuclear envelope disassembly (GO:0007077)3.65600153
71positive regulation of DNA-dependent DNA replication (GO:2000105)3.65349625
72kinetochore assembly (GO:0051382)3.64193369
73regulation of acrosome reaction (GO:0060046)3.62388975
74protein localization to chromosome, centromeric region (GO:0071459)3.59540814
75chromosome segregation (GO:0007059)3.58925464
76fatty acid homeostasis (GO:0055089)3.56893629
77protein localization to chromosome (GO:0034502)3.56149040
78glycine metabolic process (GO:0006544)3.56033962
79serine family amino acid catabolic process (GO:0009071)3.55818544
80opioid receptor signaling pathway (GO:0038003)3.54711778
81positive regulation of chromosome segregation (GO:0051984)3.53094520
82regulation of DNA methylation (GO:0044030)3.51455524
83acylglycerol catabolic process (GO:0046464)3.49842397
84neutral lipid catabolic process (GO:0046461)3.49842397
85positive regulation of mitotic sister chromatid separation (GO:1901970)3.49580780
86positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.49580780
87positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.49580780
88regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.47999521
89membrane disassembly (GO:0030397)3.47823757
90nuclear envelope disassembly (GO:0051081)3.47823757
91cytoskeleton-dependent cytokinesis (GO:0061640)3.46177387
92regulation of mitotic spindle organization (GO:0060236)3.45967327
93centriole replication (GO:0007099)3.45061486
94mitotic sister chromatid cohesion (GO:0007064)3.40488932
95regulation of chromosome segregation (GO:0051983)3.40277722
96negative regulation of histone methylation (GO:0031061)3.37933268
97protein localization to kinetochore (GO:0034501)3.37823494
98parturition (GO:0007567)3.35965378
99negative regulation of fatty acid biosynthetic process (GO:0045717)3.35834095
100behavioral response to ethanol (GO:0048149)3.35746726
101spindle checkpoint (GO:0031577)3.32873306
102adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.31153999
103negative regulation of reproductive process (GO:2000242)3.30846076
104CENP-A containing nucleosome assembly (GO:0034080)3.29887424
105ethanol oxidation (GO:0006069)3.29869583
106DNA replication checkpoint (GO:0000076)3.29039236
107protein K6-linked ubiquitination (GO:0085020)3.26903123
108omega-hydroxylase P450 pathway (GO:0097267)3.25253735
109DNA replication-independent nucleosome assembly (GO:0006336)3.23385746
110DNA replication-independent nucleosome organization (GO:0034724)3.23385746
111peptidyl-glutamic acid carboxylation (GO:0017187)3.23350824
112protein carboxylation (GO:0018214)3.23350824
113regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.23119513
114regulation of steroid hormone biosynthetic process (GO:0090030)3.22859833
115negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.19800548
116regulation of cell cycle G2/M phase transition (GO:1902749)3.18626494
117positive regulation of megakaryocyte differentiation (GO:0045654)3.18541753
118regulation of mononuclear cell migration (GO:0071675)3.17694715
119glyoxylate metabolic process (GO:0046487)3.17431485
120glycerolipid catabolic process (GO:0046503)3.16779202
121cellular ketone body metabolic process (GO:0046950)3.16613183
122chromatin remodeling at centromere (GO:0031055)3.15011675
123forebrain morphogenesis (GO:0048853)3.14129082
124regulation of gene expression by genetic imprinting (GO:0006349)3.14024634
125negative regulation of alcohol biosynthetic process (GO:1902931)3.12701312
126regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.12067493
127regulation of centriole replication (GO:0046599)3.11797902
128regulation of macrophage chemotaxis (GO:0010758)3.11442055
129negative regulation of cell division (GO:0051782)3.10444910
130regulation of G2/M transition of mitotic cell cycle (GO:0010389)3.09728905
131central nervous system myelination (GO:0022010)3.04455808
132axon ensheathment in central nervous system (GO:0032291)3.04455808
133adult feeding behavior (GO:0008343)3.02210752
134positive regulation by host of viral transcription (GO:0043923)3.00851528
135short-chain fatty acid metabolic process (GO:0046459)3.00224294
136regulation of protein activation cascade (GO:2000257)2.95069110
137regulation of complement activation (GO:0030449)2.84469445
138carnitine shuttle (GO:0006853)2.84319587
139white fat cell differentiation (GO:0050872)2.82933494
140fatty acid transmembrane transport (GO:1902001)2.82714935
141quaternary ammonium group transport (GO:0015697)2.76928284
142blood coagulation, intrinsic pathway (GO:0007597)2.75867245
143negative regulation of fatty acid metabolic process (GO:0045922)2.72564877
144regulation of glutamate receptor signaling pathway (GO:1900449)2.72030144
145aromatic amino acid family catabolic process (GO:0009074)2.71417595
146ketone body metabolic process (GO:1902224)2.71264684
147urea metabolic process (GO:0019627)2.70295918
148plasma lipoprotein particle clearance (GO:0034381)2.68215806
149serine family amino acid metabolic process (GO:0009069)2.66574125
150definitive hemopoiesis (GO:0060216)2.64013097
151complement activation, alternative pathway (GO:0006957)2.63622466
152epoxygenase P450 pathway (GO:0019373)2.63126065
153thyroid gland development (GO:0030878)2.61959324
154serine family amino acid biosynthetic process (GO:0009070)2.60999386
155triglyceride homeostasis (GO:0070328)2.60906064
156acylglycerol homeostasis (GO:0055090)2.60906064
157amino-acid betaine metabolic process (GO:0006577)2.60040188
158carnitine transmembrane transport (GO:1902603)2.57800146
159negative regulation of granulocyte differentiation (GO:0030853)2.56198454
160regulation of translational termination (GO:0006449)2.56113175
161negative regulation of neurotransmitter secretion (GO:0046929)2.54215200
162L-serine metabolic process (GO:0006563)2.53433326
163negative regulation of fibrinolysis (GO:0051918)2.52248769
164amino-acid betaine transport (GO:0015838)2.51244639
165carnitine transport (GO:0015879)2.51244639
166urea cycle (GO:0000050)2.50825662
167ethanol metabolic process (GO:0006067)2.50491935
168negative regulation of erythrocyte differentiation (GO:0045647)2.50232100
169regulation of fibrinolysis (GO:0051917)2.49226913
170triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.48992356
171regulation of glucose import in response to insulin stimulus (GO:2001273)2.48172058
172negative regulation of cholesterol transport (GO:0032375)2.40237277
173negative regulation of sterol transport (GO:0032372)2.40237277
174nitrogen cycle metabolic process (GO:0071941)2.39212938
175nitric oxide mediated signal transduction (GO:0007263)2.38821277
176heart trabecula formation (GO:0060347)2.36341459
177alpha-amino acid catabolic process (GO:1901606)2.34887383
178low-density lipoprotein particle clearance (GO:0034383)2.29317686
179response to parathyroid hormone (GO:0071107)2.29315948
180plasma lipoprotein particle remodeling (GO:0034369)2.29156333
181protein-lipid complex remodeling (GO:0034368)2.29156333
182macromolecular complex remodeling (GO:0034367)2.29156333
183astrocyte development (GO:0014002)2.28810731
184glucose catabolic process (GO:0006007)2.28736760
185response to nitrosative stress (GO:0051409)2.27644786
186positive regulation of gluconeogenesis (GO:0045722)2.27260797
187fatty acid beta-oxidation (GO:0006635)2.26902149
188positive regulation of glycogen biosynthetic process (GO:0045725)2.26766480
189positive regulation of cellular response to insulin stimulus (GO:1900078)2.25967073
190fatty acid catabolic process (GO:0009062)2.25777747
191fatty acid oxidation (GO:0019395)2.24553183
192intestinal cholesterol absorption (GO:0030299)2.23759590
193regulation of cholesterol biosynthetic process (GO:0045540)2.22620762
194collecting duct development (GO:0072044)2.21955113
195monocarboxylic acid catabolic process (GO:0072329)2.21768957
196negative regulation of fatty acid transport (GO:2000192)2.20982672
197negative regulation of gluconeogenesis (GO:0045721)2.20073235
198dicarboxylic acid biosynthetic process (GO:0043650)2.20010507

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.90540730
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.46407347
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.25890495
4SALL1_21062744_ChIP-ChIP_HESCs_Human4.08330170
5E2F7_22180533_ChIP-Seq_HELA_Human3.97129750
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.91879712
7SMAD_19615063_ChIP-ChIP_OVARY_Human3.57102976
8AR_21909140_ChIP-Seq_LNCAP_Human3.23898557
9KAP1_22055183_ChIP-Seq_ESCs_Mouse3.09827591
10RXR_22158963_ChIP-Seq_LIVER_Mouse3.02111564
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.78529232
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.66855560
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.63514182
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.58197993
15PPARA_22158963_ChIP-Seq_LIVER_Mouse2.51469941
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.44681048
17VDR_21846776_ChIP-Seq_THP-1_Human2.43451272
18MYC_22102868_ChIP-Seq_BL_Human2.27100456
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.26279073
20NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.20336413
21STAT6_21828071_ChIP-Seq_BEAS2B_Human2.20112919
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.18773328
23GATA1_26923725_Chip-Seq_HPCs_Mouse2.11302506
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.08995583
25IGF1R_20145208_ChIP-Seq_DFB_Human2.07984469
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97944140
27FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.96206623
28SCL_19346495_ChIP-Seq_HPC-7_Human1.87315470
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.87037904
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85280670
31CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85220595
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.79704421
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.77860061
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.77099441
35SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.76581293
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.75897355
37RNF2_18974828_ChIP-Seq_MESCs_Mouse1.75897355
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74257364
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.72803756
40MTF2_20144788_ChIP-Seq_MESCs_Mouse1.71975613
41LXR_22292898_ChIP-Seq_THP-1_Human1.71007951
42HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.69239090
43EZH2_22144423_ChIP-Seq_EOC_Human1.69106611
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.68861993
45FOXA2_19822575_ChIP-Seq_HepG2_Human1.68051782
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.66044650
47TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.65113539
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.64696505
49TP53_20018659_ChIP-ChIP_R1E_Mouse1.63599809
50PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.62990960
51MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.62270586
52FUS_26573619_Chip-Seq_HEK293_Human1.60859821
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60556147
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.59508390
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.59255621
56ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.59241813
57DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.58131431
58KDM2B_26808549_Chip-Seq_K562_Human1.57466350
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57344730
60JARID2_20075857_ChIP-Seq_MESCs_Mouse1.56484913
61CREB1_26743006_Chip-Seq_LNCaP_Human1.55774431
62RUNX1_26923725_Chip-Seq_HPCs_Mouse1.53424515
63KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.52978740
64KDM2B_26808549_Chip-Seq_DND41_Human1.51792699
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50941965
66BP1_19119308_ChIP-ChIP_Hs578T_Human1.48325000
67P68_20966046_ChIP-Seq_HELA_Human1.47977777
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47852754
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.44403326
70LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44154892
71FOXM1_26456572_ChIP-Seq_MCF-7_Human1.44150097
72KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43349519
73RNF2_27304074_Chip-Seq_NSC_Mouse1.43099265
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.41750352
75SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.41349562
76MYC_18940864_ChIP-ChIP_HL60_Human1.39988691
77STAT3_23295773_ChIP-Seq_U87_Human1.39439645
78MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.38165100
79TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37614680
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37605920
81WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37442666
82CDX2_22108803_ChIP-Seq_LS180_Human1.36904557
83RNF2_27304074_Chip-Seq_ESCs_Mouse1.34696635
84EWS_26573619_Chip-Seq_HEK293_Human1.32588151
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32569515
86ESR1_15608294_ChIP-ChIP_MCF-7_Human1.31721661
87EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.31575877
88CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31103065
89EZH2_27294783_Chip-Seq_ESCs_Mouse1.30893744
90DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30442532
91SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.30359052
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30084885
93DROSHA_22980978_ChIP-Seq_HELA_Human1.28813992
94SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.28740673
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28197742
96EZH2_27304074_Chip-Seq_ESCs_Mouse1.27705864
97CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.27517566
98CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.26229909
99AR_21572438_ChIP-Seq_LNCaP_Human1.26197689
100BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25998490
101CBX2_27304074_Chip-Seq_ESCs_Mouse1.25917310
102TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25166798
103EED_16625203_ChIP-ChIP_MESCs_Mouse1.24005099
104STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.23252321
105SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.21510527
106TCF7_22412390_ChIP-Seq_EML_Mouse1.20949704
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20469513
108RACK7_27058665_Chip-Seq_MCF-7_Human1.19988193
109RARB_27405468_Chip-Seq_BRAIN_Mouse1.19890595
110CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.19798175
111FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.19759679
112RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18161010
113EGR1_23403033_ChIP-Seq_LIVER_Mouse1.17321607
114SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16665936
115STAT1_17558387_ChIP-Seq_HELA_Human1.16540741
116SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.16103023
117SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15945789
118TP63_19390658_ChIP-ChIP_HaCaT_Human1.14653294
119HNF4A_19822575_ChIP-Seq_HepG2_Human1.14501889
120SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13489618
121NANOG_18555785_Chip-Seq_ESCs_Mouse1.13258715
122NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.13053113
123CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.11833807
124TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11828276
125POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11828276
126AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10422552
127NFYA_21822215_ChIP-Seq_K562_Human1.10015139
128CTCF_27219007_Chip-Seq_Bcells_Human1.09186407
129SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07870361
130RING1B_27294783_Chip-Seq_ESCs_Mouse1.07365810
131NANOG_21062744_ChIP-ChIP_HESCs_Human1.07198017
132ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06783159
133TBL1_22424771_ChIP-Seq_293T_Human1.06655080
134TET1_21451524_ChIP-Seq_MESCs_Mouse1.06599802
135TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06440861
136* MITF_21258399_ChIP-Seq_MELANOMA_Human1.06395929
137VDR_24763502_ChIP-Seq_THP-1_Human1.06285808
138MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.06095171
139TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06072291
140ZNF263_19887448_ChIP-Seq_K562_Human1.04918731
141KDM2B_26808549_Chip-Seq_REH_Human1.04508552
142KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04236009
143ELK4_26923725_Chip-Seq_MESODERM_Mouse1.03867353
144WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03664684
145SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.02934077
146TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02195086
147EZH2_27294783_Chip-Seq_NPCs_Mouse1.02184621
148SMAD4_21799915_ChIP-Seq_A2780_Human1.02137206
149SMC4_20622854_ChIP-Seq_HELA_Human1.01321764
150PKCTHETA_26484144_Chip-Seq_BREAST_Human0.99842917
151CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99480366
152CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99151376
153FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.98542136
154NFE2_27457419_Chip-Seq_LIVER_Mouse0.98245823
155HTT_18923047_ChIP-ChIP_STHdh_Human0.97783802
156GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95294630
157TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.94927528
158CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94269400
159RXRA_24833708_ChIP-Seq_LIVER_Mouse0.94063773
160MYC_27129775_Chip-Seq_CORNEA_Mouse0.93447594
161AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.92748721
162FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.92567389
163PRDM14_20953172_ChIP-Seq_ESCs_Human0.91379744
164EP300_21415370_ChIP-Seq_HL-1_Mouse0.90645297
165FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90584500
166SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90337305
167CLOCK_20551151_ChIP-Seq_293T_Human0.89464197
168PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.89347696
169ISL1_27105846_Chip-Seq_CPCs_Mouse0.89081806
170* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88669828
171TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.88531080
172TCF4_23295773_ChIP-Seq_U87_Human0.88408544
173GATA3_21867929_ChIP-Seq_TH1_Mouse0.88362347
174EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88278952
175PIAS1_25552417_ChIP-Seq_VCAP_Human0.88141794
176* TP63_23658742_ChIP-Seq_EP156T_Human0.87771566
177SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.87593224
178* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.87030907
179CTCF_18555785_Chip-Seq_ESCs_Mouse0.86659448
180TBX20_22328084_ChIP-Seq_HEART_Mouse0.86457155
181TBX20_22080862_ChIP-Seq_HEART_Mouse0.86457155
182ERG_20517297_ChIP-Seq_VCAP_Human0.86140649
183GF1B_26923725_Chip-Seq_HPCs_Mouse0.86030154
184RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.85869502
185E2F1_17053090_ChIP-ChIP_MCF-7_Human0.85774925
186STAT3_18555785_Chip-Seq_ESCs_Mouse0.85299258
187CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.84764167

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect6.71661619
2MP0005451_abnormal_body_composition5.08880713
3MP0003646_muscle_fatigue4.78661026
4MP0002102_abnormal_ear_morphology4.73502792
5MP0003787_abnormal_imprinting4.48709770
6MP0002876_abnormal_thyroid_physiology4.02067903
7MP0005670_abnormal_white_adipose4.01595157
8MP0002139_abnormal_hepatobiliary_system3.88001389
9MP0003693_abnormal_embryo_hatching3.53563082
10MP0003283_abnormal_digestive_organ3.51982029
11MP0008877_abnormal_DNA_methylation3.37048849
12MP0002653_abnormal_ependyma_morphology3.07913152
13MP0003121_genomic_imprinting3.05957052
14MP0005395_other_phenotype3.04244627
15MP0010094_abnormal_chromosome_stability2.91335988
16MP0005666_abnormal_adipose_tissue2.71811151
17MP0003699_abnormal_female_reproductive2.67972423
18MP0001119_abnormal_female_reproductive2.60648519
19MP0009780_abnormal_chondrocyte_physiolo2.59221603
20MP0005365_abnormal_bile_salt2.56531980
21MP0003077_abnormal_cell_cycle2.55904439
22MP0004957_abnormal_blastocyst_morpholog2.49181697
23MP0000681_abnormal_thyroid_gland2.46894623
24MP0004130_abnormal_muscle_cell2.42919664
25MP0009278_abnormal_bone_marrow2.42218628
26MP0005408_hypopigmentation2.31939674
27MP0003123_paternal_imprinting2.29673278
28MP0002971_abnormal_brown_adipose2.27669099
29MP0003111_abnormal_nucleus_morphology2.26052445
30MP0006292_abnormal_olfactory_placode2.23282680
31MP0002249_abnormal_larynx_morphology2.12577984
32MP0004264_abnormal_extraembryonic_tissu2.04476750
33MP0005375_adipose_tissue_phenotype2.02554875
34MP0005220_abnormal_exocrine_pancreas2.00687086
35MP0001929_abnormal_gametogenesis2.00458132
36MP0000653_abnormal_sex_gland2.00321528
37MP0003195_calcinosis2.00228166
38MP0002138_abnormal_hepatobiliary_system1.98863121
39MP0002396_abnormal_hematopoietic_system1.93645997
40MP0005360_urolithiasis1.89420214
41MP0005503_abnormal_tendon_morphology1.85849932
42MP0002210_abnormal_sex_determination1.83599092
43MP0003959_abnormal_lean_body1.81671951
44MP0000579_abnormal_nail_morphology1.79306762
45MP0003937_abnormal_limbs/digits/tail_de1.78220354
46MP0003122_maternal_imprinting1.67581536
47MP0001944_abnormal_pancreas_morphology1.66936695
48MP0010329_abnormal_lipoprotein_level1.64419555
49MP0000003_abnormal_adipose_tissue1.63554899
50MP0000462_abnormal_digestive_system1.63380609
51MP0003868_abnormal_feces_composition1.59537836
52MP0008932_abnormal_embryonic_tissue1.59144817
53MP0005085_abnormal_gallbladder_physiolo1.58530761
54MP0010368_abnormal_lymphatic_system1.54842921
55MP0004185_abnormal_adipocyte_glucose1.51963291
56MP0005409_darkened_coat_color1.49742890
57MP0002877_abnormal_melanocyte_morpholog1.47454389
58MP0003567_abnormal_fetal_cardiomyocyte1.43008815
59MP0002085_abnormal_embryonic_tissue1.41768258
60MP0005310_abnormal_salivary_gland1.41497314
61MP0003172_abnormal_lysosome_physiology1.41249435
62MP0003943_abnormal_hepatobiliary_system1.38266657
63MP0002928_abnormal_bile_duct1.38121914
64MP0001545_abnormal_hematopoietic_system1.37113597
65MP0005397_hematopoietic_system_phenotyp1.37113597
66MP0002161_abnormal_fertility/fecundity1.35757379
67MP0002118_abnormal_lipid_homeostasis1.33171090
68MP0001697_abnormal_embryo_size1.31164070
69MP0000350_abnormal_cell_proliferation1.29671469
70MP0001145_abnormal_male_reproductive1.29630425
71MP0004808_abnormal_hematopoietic_stem1.29108765
72MP0008007_abnormal_cellular_replicative1.26075698
73MP0001968_abnormal_touch/_nociception1.25889335
74MP0001661_extended_life_span1.25370018
75MP0001664_abnormal_digestion1.24922287
76MP0001730_embryonic_growth_arrest1.24538905
77MP0002078_abnormal_glucose_homeostasis1.22990339
78MP0002970_abnormal_white_adipose1.22077191
79MP0005332_abnormal_amino_acid1.21633944
80MP0001915_intracranial_hemorrhage1.20092593
81MP0002084_abnormal_developmental_patter1.19535448
82MP0000639_abnormal_adrenal_gland1.19464216
83MP0009115_abnormal_fat_cell1.14207623
84MP0003252_abnormal_bile_duct1.14135067
85MP0001270_distended_abdomen1.13813178
86MP0003183_abnormal_peptide_metabolism1.13512359
87MP0005334_abnormal_fat_pad1.09519421
88MP0010234_abnormal_vibrissa_follicle1.09093672
89MP0001672_abnormal_embryogenesis/_devel1.08809935
90MP0005380_embryogenesis_phenotype1.08809935
91MP0009672_abnormal_birth_weight1.07899464
92MP0005646_abnormal_pituitary_gland1.07622328
93MP0005084_abnormal_gallbladder_morpholo1.02006893
94MP0003690_abnormal_glial_cell0.99891311
95MP0001529_abnormal_vocalization0.99668569
96MP0003755_abnormal_palate_morphology0.99395683
97MP0002160_abnormal_reproductive_system0.97753630
98MP0009643_abnormal_urine_homeostasis0.96354994
99MP0005535_abnormal_body_temperature0.95989679
100MP0005452_abnormal_adipose_tissue0.95890237
101MP0005448_abnormal_energy_balance0.94972958
102MP0001502_abnormal_circadian_rhythm0.94935270
103MP0003953_abnormal_hormone_level0.93962873
104MP0001851_eye_inflammation0.93684806
105MP0005379_endocrine/exocrine_gland_phen0.92711861
106MP0001346_abnormal_lacrimal_gland0.92481804
107MP0003315_abnormal_perineum_morphology0.91812571
108MP0004043_abnormal_pH_regulation0.90715954
109MP0001881_abnormal_mammary_gland0.90415677
110MP0009697_abnormal_copulation0.88611754
111MP0003879_abnormal_hair_cell0.88287623
112MP0002019_abnormal_tumor_incidence0.87419292
113MP0001905_abnormal_dopamine_level0.86485221
114MP0003633_abnormal_nervous_system0.84247396
115MP0002108_abnormal_muscle_morphology0.83975147
116MP0004858_abnormal_nervous_system0.83820422
117MP0001764_abnormal_homeostasis0.83802999
118MP0003890_abnormal_embryonic-extraembry0.82893496
119MP0009250_abnormal_appendicular_skeleto0.82504444
120MP0001188_hyperpigmentation0.82168924
121MP0010630_abnormal_cardiac_muscle0.82062734
122MP0001756_abnormal_urination0.82005248
123MP0004782_abnormal_surfactant_physiolog0.81107267
124MP0008057_abnormal_DNA_replication0.80633422
125MP0004134_abnormal_chest_morphology0.80355491
126MP0002693_abnormal_pancreas_physiology0.79209820
127MP0000566_synostosis0.76452615
128MP0000609_abnormal_liver_physiology0.75820529
129MP0004510_myositis0.75165394
130MP0003984_embryonic_growth_retardation0.74799224
131MP0009379_abnormal_foot_pigmentation0.74731430
132MP0005551_abnormal_eye_electrophysiolog0.73938339
133MP0003656_abnormal_erythrocyte_physiolo0.73805223
134MP0008875_abnormal_xenobiotic_pharmacok0.72542452
135MP0003698_abnormal_male_reproductive0.71567080
136MP0001501_abnormal_sleep_pattern0.71302747
137MP0008058_abnormal_DNA_repair0.70909613
138MP0002116_abnormal_craniofacial_bone0.70337323
139MP0002932_abnormal_joint_morphology0.70084742
140MP0002088_abnormal_embryonic_growth/wei0.69949233
141MP0000598_abnormal_liver_morphology0.67742044
142MP0004145_abnormal_muscle_electrophysio0.67621243
143MP0002009_preneoplasia0.67616051
144MP0003861_abnormal_nervous_system0.67492405
145MP0004197_abnormal_fetal_growth/weight/0.67426431
146MP0000733_abnormal_muscle_development0.67351056
147MP0002086_abnormal_extraembryonic_tissu0.66876600
148MP0006138_congestive_heart_failure0.66727306
149MP0005621_abnormal_cell_physiology0.66469475
150MP0009384_cardiac_valve_regurgitation0.65811319
151MP0002909_abnormal_adrenal_gland0.64970619
152MP0000631_abnormal_neuroendocrine_gland0.64400524
153MP0003453_abnormal_keratinocyte_physiol0.63460060
154MP0005647_abnormal_sex_gland0.63452656
155MP0002177_abnormal_outer_ear0.62972759
156MP0000013_abnormal_adipose_tissue0.62760873
157MP0010307_abnormal_tumor_latency0.62609502
158MP0001919_abnormal_reproductive_system0.61921484
159MP0000432_abnormal_head_morphology0.61199021
160MP0003091_abnormal_cell_migration0.61140641
161MP0000678_abnormal_parathyroid_gland0.61138476
162MP0002638_abnormal_pupillary_reflex0.60982182
163MP0010030_abnormal_orbit_morphology0.60367312
164MP0003935_abnormal_craniofacial_develop0.60334700
165MP0004233_abnormal_muscle_weight0.60145143
166MP0000427_abnormal_hair_cycle0.60129852
167MP0010386_abnormal_urinary_bladder0.59906237
168MP0001849_ear_inflammation0.59693183
169MP0002822_catalepsy0.58933518
170MP0003942_abnormal_urinary_system0.58801877
171MP0004270_analgesia0.58585443
172MP0001324_abnormal_eye_pigmentation0.58330798
173MP0004859_abnormal_synaptic_plasticity0.58028500
174MP0002080_prenatal_lethality0.57373177
175MP0003763_abnormal_thymus_physiology0.57155356
176MP0000569_abnormal_digit_pigmentation0.56595346
177MP0003950_abnormal_plasma_membrane0.56202282
178MP0005187_abnormal_penis_morphology0.55649144
179MP0003136_yellow_coat_color0.55260546
180MP0001666_abnormal_nutrient_absorption0.55032074
181MP0002282_abnormal_trachea_morphology0.54940528
182MP0000490_abnormal_crypts_of0.54523321
183MP0000767_abnormal_smooth_muscle0.53908862
184MP0005384_cellular_phenotype0.52528199
185MP0002109_abnormal_limb_morphology0.52168902
186MP0005023_abnormal_wound_healing0.51974378
187MP0002168_other_aberrant_phenotype0.49536969

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)6.53411756
2Cortical dysplasia (HP:0002539)5.93892036
3Male infertility (HP:0003251)5.75596229
4Thyroid-stimulating hormone excess (HP:0002925)5.15495242
5Chromsome breakage (HP:0040012)4.84109568
6Shawl scrotum (HP:0000049)4.82295079
7Flat capital femoral epiphysis (HP:0003370)4.67426549
8Acute myeloid leukemia (HP:0004808)4.30845308
9Facial hemangioma (HP:0000329)4.25475184
10Abnormality of the fingertips (HP:0001211)4.18799442
11Chromosomal breakage induced by crosslinking agents (HP:0003221)4.12661717
12Hyperthyroidism (HP:0000836)4.03571033
13Insulin-resistant diabetes mellitus (HP:0000831)4.00120498
14Abnormality of the labia minora (HP:0012880)3.98626605
15Adrenal hypoplasia (HP:0000835)3.96095182
16Lip pit (HP:0100267)3.95039788
17Patellar aplasia (HP:0006443)3.85564512
18Ketoacidosis (HP:0001993)3.81762737
19Pancreatic islet-cell hyperplasia (HP:0004510)3.77594080
20Birth length less than 3rd percentile (HP:0003561)3.72553748
21Deep venous thrombosis (HP:0002625)3.72156565
22Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.63528716
23Hypoglycemic seizures (HP:0002173)3.60554774
24Abnormality of the pancreatic islet cells (HP:0006476)3.58484772
25Abnormality of endocrine pancreas physiology (HP:0012093)3.58484772
26Macroorchidism (HP:0000053)3.57772144
27Aplasia/Hypoplasia of the patella (HP:0006498)3.53385847
28Abnormality of aromatic amino acid family metabolism (HP:0004338)3.53260122
29Hyperinsulinemic hypoglycemia (HP:0000825)3.52611442
30Large for gestational age (HP:0001520)3.49838396
31Thyroid carcinoma (HP:0002890)3.47459345
32Prolonged partial thromboplastin time (HP:0003645)3.35965252
33Hypercortisolism (HP:0001578)3.34328004
34Complement deficiency (HP:0004431)3.32675800
35Breast hypoplasia (HP:0003187)3.31869195
36Ketosis (HP:0001946)3.22345977
37Hyperglycemia (HP:0003074)3.18168031
38Capillary hemangiomas (HP:0005306)3.17772959
39Abnormality of the intrinsic pathway (HP:0010989)3.16514430
40Acute lymphatic leukemia (HP:0006721)3.16245660
41Sandal gap (HP:0001852)3.10694038
42Abnormality of chromosome segregation (HP:0002916)3.09926621
43Hypoglycemic coma (HP:0001325)3.08442790
44Sparse lateral eyebrow (HP:0005338)3.07109179
45Secondary amenorrhea (HP:0000869)3.05988041
46Abnormality of lateral ventricle (HP:0030047)2.93590764
47Hypergonadotropic hypogonadism (HP:0000815)2.92856507
48Arterial tortuosity (HP:0005116)2.92447399
49Neonatal hypoglycemia (HP:0001998)2.91388104
50Pulmonary fibrosis (HP:0002206)2.90524757
51Chronic bronchitis (HP:0004469)2.81796604
52Premature ovarian failure (HP:0008209)2.81572870
53Volvulus (HP:0002580)2.80594324
54Mesangial abnormality (HP:0001966)2.79871147
55Abnormal gallbladder physiology (HP:0012438)2.79448797
56Cholecystitis (HP:0001082)2.79448797
57Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.78840574
58Thoracic kyphosis (HP:0002942)2.72282465
59Abnormality of chromosome stability (HP:0003220)2.67866252
60Oligodactyly (hands) (HP:0001180)2.67250444
61Spondylolisthesis (HP:0003302)2.65904900
62Late onset (HP:0003584)2.61969920
63Diastasis recti (HP:0001540)2.59413777
64Breast aplasia (HP:0100783)2.53371770
65Midline defect of the nose (HP:0004122)2.52740935
66Vascular tortuosity (HP:0004948)2.51738400
67Aplasia/Hypoplasia of the breasts (HP:0010311)2.51536809
68Overlapping toe (HP:0001845)2.48683822
69Retinal atrophy (HP:0001105)2.46458887
70Hemorrhage of the eye (HP:0011885)2.46235125
71Hyperglycinuria (HP:0003108)2.45678176
72Primary amenorrhea (HP:0000786)2.44480987
73Oligodactyly (HP:0012165)2.43296305
74Hypercholesterolemia (HP:0003124)2.41378777
75Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.38584011
76Malnutrition (HP:0004395)2.38234058
77Abnormality of serine family amino acid metabolism (HP:0010894)2.37413684
78Abnormality of glycine metabolism (HP:0010895)2.37413684
79Aplasia/Hypoplasia of the uvula (HP:0010293)2.37049106
80Pigmentary retinal degeneration (HP:0001146)2.35740801
81Urethral obstruction (HP:0000796)2.34541159
82Abnormality of the phalanges of the hallux (HP:0010057)2.30864963
83Joint hemorrhage (HP:0005261)2.30266196
84Abnormality of the epiphysis of the femoral head (HP:0010574)2.28925058
85Infertility (HP:0000789)2.27133769
86Abnormality of the thoracic spine (HP:0100711)2.26725745
87Supernumerary spleens (HP:0009799)2.24937630
88Asymmetry of the thorax (HP:0001555)2.22714750
89Abnormality of the proximal phalanges of the hand (HP:0009834)2.22261630
90Abnormality of the fovea (HP:0000493)2.22211001
91Camptodactyly of toe (HP:0001836)2.21006962
92Oligodontia (HP:0000677)2.20456772
93Prostate neoplasm (HP:0100787)2.19799160
94Hyperlipoproteinemia (HP:0010980)2.19644639
95Atrioventricular block (HP:0001678)2.19289271
96Abnormality of complement system (HP:0005339)2.18974839
97Villous atrophy (HP:0011473)2.18109726
98Abnormality of small intestinal villus morphology (HP:0011472)2.18109726
99Abnormality of the aortic arch (HP:0012303)2.17159151
100Ectopic kidney (HP:0000086)2.16521807
101Abnormality of monocarboxylic acid metabolism (HP:0010996)2.15118460
102Neoplasm of the oral cavity (HP:0100649)2.14792120
103Anterior segment dysgenesis (HP:0007700)2.13733922
104Abnormality of the preputium (HP:0100587)2.11659359
105Adrenal overactivity (HP:0002717)2.09363589
106Abnormality of the femoral head (HP:0003368)2.08943280
107Abnormality of fatty-acid metabolism (HP:0004359)2.08262936
108Truncal obesity (HP:0001956)2.07987336
109Impulsivity (HP:0100710)2.07334592
110Meckel diverticulum (HP:0002245)2.06974049
111Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.06744045
112Abnormality of femoral epiphyses (HP:0006499)2.06744045
113Testicular neoplasm (HP:0010788)2.02201008
114Facial shape deformation (HP:0011334)2.01464210
115Potter facies (HP:0002009)2.01464210
116Sloping forehead (HP:0000340)2.01363539
117Hyperpituitarism (HP:0010514)1.99444017
118Cystic hygroma (HP:0000476)1.98296885
119Neoplasm of the adrenal cortex (HP:0100641)1.98109313
120Hypoplastic iliac wings (HP:0002866)1.98020781
121Metaphyseal dysplasia (HP:0100255)1.97769023
122Hyperammonemia (HP:0001987)1.97107664
123Wrist flexion contracture (HP:0001239)1.94541824
124Xanthomatosis (HP:0000991)1.94100429
125Obstructive sleep apnea (HP:0002870)1.93537602
126Pseudobulbar signs (HP:0002200)1.92821739
127Hyperglycinemia (HP:0002154)1.92630931
128Goiter (HP:0000853)1.92298025
129Enlarged kidneys (HP:0000105)1.92127882
130Rhabdomyosarcoma (HP:0002859)1.91798755
131Unilateral renal agenesis (HP:0000122)1.90701947
132Abnormality of the ileum (HP:0001549)1.90581282
133Long toe (HP:0010511)1.90426643
134Clubbing of toes (HP:0100760)1.89541952
135Reduced antithrombin III activity (HP:0001976)1.88117917
136Short thumb (HP:0009778)1.87994409
137Chorioretinal atrophy (HP:0000533)1.87192132
138Chin dimple (HP:0010751)1.85734280
139Arachnodactyly (HP:0001166)1.84616265
140Enlarged penis (HP:0000040)1.84147493
141Medulloblastoma (HP:0002885)1.82678926
142Genetic anticipation (HP:0003743)1.82639751
143Mucopolysacchariduria (HP:0008155)1.82198917
144Urinary glycosaminoglycan excretion (HP:0003541)1.82198917
145Depressed nasal tip (HP:0000437)1.82143868
146Cerebellar dysplasia (HP:0007033)1.81759965
147Duodenal stenosis (HP:0100867)1.81043414
148Small intestinal stenosis (HP:0012848)1.81043414
149Thickened helices (HP:0000391)1.78333869
150Abnormality of midbrain morphology (HP:0002418)1.77120065
151Molar tooth sign on MRI (HP:0002419)1.77120065
152Abnormality of the common coagulation pathway (HP:0010990)1.77110947
153Osteomalacia (HP:0002749)1.76745027
154Aplasia/Hypoplasia of the fovea (HP:0008060)1.76674198
155Hypoplasia of the fovea (HP:0007750)1.76674198
156Retrobulbar optic neuritis (HP:0100654)1.76662479
157Optic neuritis (HP:0100653)1.76662479
158Rib fusion (HP:0000902)1.76325998
159Absent radius (HP:0003974)1.76314923
160Myelodysplasia (HP:0002863)1.75354297
161Insulin resistance (HP:0000855)1.75186131
162Fibular aplasia (HP:0002990)1.74784005
163Dicarboxylic aciduria (HP:0003215)1.74644185
164Abnormality of dicarboxylic acid metabolism (HP:0010995)1.74644185
165Delayed CNS myelination (HP:0002188)1.73823853
166Abnormality of the columella (HP:0009929)1.72748112
167Aplasia/Hypoplasia of the earlobes (HP:0009906)1.70957636
168Intestinal atresia (HP:0011100)1.70736014
169Venous insufficiency (HP:0005293)1.69665470
170Aplasia involving forearm bones (HP:0009822)1.69227054
171Absent forearm bone (HP:0003953)1.69227054
172Atelectasis (HP:0100750)1.68925908
173Abnormality of the intervertebral disk (HP:0005108)1.68767052
174Cafe-au-lait spot (HP:0000957)1.67720468
175Abnormality of polysaccharide metabolism (HP:0011012)1.67440364
176Abnormality of glycosaminoglycan metabolism (HP:0004371)1.67440364
177Abnormality of mucopolysaccharide metabolism (HP:0011020)1.67440364
178Abnormal respiratory motile cilium physiology (HP:0012261)1.66782699
179Polygenic inheritance (HP:0010982)1.64346777
180Exercise-induced myalgia (HP:0003738)1.63082509
181Abnormal pancreas size (HP:0012094)1.61570121
182Polydipsia (HP:0001959)1.60923131
183Abnormal drinking behavior (HP:0030082)1.60923131
184Symptomatic seizures (HP:0011145)1.60376776
185Lymphangioma (HP:0100764)1.59625521
186Growth hormone excess (HP:0000845)1.58759917
187Systemic lupus erythematosus (HP:0002725)1.56759704
188Back pain (HP:0003418)1.56754814
189Abnormality of the vitreous humor (HP:0004327)1.56552156
190Lower limb asymmetry (HP:0100559)1.54513859
191Asymmetric septal hypertrophy (HP:0001670)1.53427448
192Craniofacial hyperostosis (HP:0004493)1.51966817
193Increased circulating renin level (HP:0000848)1.50708891
194Truncal ataxia (HP:0002078)1.49375681
195Dysdiadochokinesis (HP:0002075)1.48926131

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.34145649
2LATS14.25630306
3MAP3K63.67083722
4LATS23.64193999
5PLK43.49067009
6ERN13.42940875
7EEF2K3.32064742
8ERBB43.21630787
9BRAF3.19098185
10KSR23.18358467
11MUSK3.12226046
12TRIB33.03888543
13TAOK12.97254585
14MAP3K92.93148427
15STK38L2.72295592
16TTK2.61909878
17MOS2.49597726
18MAP3K132.45782207
19ICK2.44889405
20PASK2.37155207
21CDC72.34691938
22FRK2.24429222
23CAMK1G2.23728727
24RAF12.23308456
25SMG12.10123836
26ARAF2.09800210
27ADRBK22.08106594
28HIPK22.04325206
29MAPKAPK32.03292564
30SIK11.88365466
31PNCK1.87678872
32CAMK1D1.82532271
33MAP3K101.78254983
34CHEK21.75695280
35STK31.65149322
36TAF11.59918692
37CDK81.55155159
38PRKD31.52613865
39VRK21.51501886
40AKT31.50041160
41KSR11.47933280
42MELK1.45751470
43BMPR21.45599692
44CDK91.40475991
45NEK21.37540599
46MAPK71.34940403
47PAK61.30352252
48MAP3K41.22106862
49MAPK131.21663959
50MAPKAPK51.18288624
51FGFR21.15608921
52STK101.13837677
53PRKD21.12686211
54DAPK21.12208401
55IRAK31.10668089
56TYRO31.09764480
57WNK41.07234513
58PHKG11.03672415
59PHKG21.03672415
60RIPK11.03210829
61CDK60.99654992
62DMPK0.98117425
63PDGFRA0.96660160
64PLK10.94014572
65CDK120.90059002
66NTRK20.87283809
67MAP2K70.86512849
68KIT0.86487490
69WNK10.86173373
70RPS6KC10.84739462
71RPS6KL10.84739462
72RPS6KB20.84094510
73MAP3K80.83663223
74RPS6KA60.83118468
75PRKAA20.82432753
76TRPM70.79826956
77STK380.79052493
78DYRK20.78314174
79PRKCH0.78024393
80MARK20.76459406
81PAK20.75123939
82CAMK10.74945047
83BCKDK0.74243478
84DYRK1A0.71785822
85ACVR1B0.70251396
86RET0.69722867
87MAP2K30.69521369
88PRKAA10.69028033
89FLT30.68020738
90MKNK10.68010789
91CSNK1G10.67770638
92MAP2K20.65148035
93BRD40.63866509
94ABL20.62707477
95AURKB0.62681674
96MAP2K40.62489409
97FGFR30.62228078
98PRKCG0.62109827
99PDPK10.59969288
100RPS6KA20.58532163
101MAPK40.58452768
102SGK10.58101052
103CHEK10.57407643
104MAPK30.55761464
105MAPK120.54556894
106MAPK150.54480783
107TIE10.53485688
108STK240.53353521
109IRAK10.53320224
110AURKA0.50698896
111RPS6KA30.50683536
112SGK20.50142866
113TGFBR10.48938471
114CDK30.48811661
115ADRBK10.48335474
116MAP3K20.47761589
117GSK3A0.47403935
118MAP3K50.47141435
119NLK0.47074219
120* GSK3B0.46854351
121NUAK10.46614473
122CSNK1G20.46560539
123UHMK10.44898102
124ATM0.44131243
125MAP3K70.43871333
126RPS6KB10.43185653
127CAMK40.41141141
128CDK40.33413544
129CSNK1G30.33261103
130ABL10.33064869
131CDK70.32870434
132MAPK110.31702134
133PINK10.31232288
134MAP3K10.31165170
135SGK4940.30321539
136SGK2230.30321539
137BUB10.29090789
138PLK30.28959006
139NEK90.28409282
140RPS6KA40.28386172
141BMPR1B0.27954717
142CDK10.26481584
143CDK20.24923359
144MAPK100.21043325
145SGK30.20542713
146EPHA30.19999646
147NEK10.19142720
148MAP2K10.19059994
149CAMK2A0.18836945
150AKT10.18016631
151CSNK1A1L0.17925262
152CSNK1D0.17476743
153MAPK140.15216406
154MTOR0.14529662
155MAP3K120.13864554
156MAPK10.12953864
157PLK20.11751630
158JAK20.11187072
159CHUK0.10854098
160PAK10.10770139
161JAK30.09614213
162STK40.08156729

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049134.09760149
2Cell cycle_Homo sapiens_hsa041104.02757237
3RNA degradation_Homo sapiens_hsa030183.63195283
4Basal transcription factors_Homo sapiens_hsa030223.00050909
5Circadian rhythm_Homo sapiens_hsa047102.92122062
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.86422319
7Pancreatic cancer_Homo sapiens_hsa052122.66790087
8Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.53418908
9Butanoate metabolism_Homo sapiens_hsa006502.50397252
10Dorso-ventral axis formation_Homo sapiens_hsa043202.42044172
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.36514347
12p53 signaling pathway_Homo sapiens_hsa041152.32278580
13Linoleic acid metabolism_Homo sapiens_hsa005912.31099772
14Fatty acid degradation_Homo sapiens_hsa000712.23312833
15Ether lipid metabolism_Homo sapiens_hsa005652.18288070
16Vitamin B6 metabolism_Homo sapiens_hsa007502.17714769
17Oocyte meiosis_Homo sapiens_hsa041142.16430315
18TGF-beta signaling pathway_Homo sapiens_hsa043502.10320717
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.03765697
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.02631440
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.02190084
22Homologous recombination_Homo sapiens_hsa034401.90943498
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.90829282
24Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.88999289
25Complement and coagulation cascades_Homo sapiens_hsa046101.85259792
26Non-homologous end-joining_Homo sapiens_hsa034501.82826570
27Fanconi anemia pathway_Homo sapiens_hsa034601.73481238
28Fatty acid metabolism_Homo sapiens_hsa012121.72756765
29GnRH signaling pathway_Homo sapiens_hsa049121.71718289
30Colorectal cancer_Homo sapiens_hsa052101.68626889
31Sulfur relay system_Homo sapiens_hsa041221.68557210
32Phenylalanine metabolism_Homo sapiens_hsa003601.68423523
33Tryptophan metabolism_Homo sapiens_hsa003801.66578256
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.65591382
35MicroRNAs in cancer_Homo sapiens_hsa052061.62080978
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.61265071
37Prolactin signaling pathway_Homo sapiens_hsa049171.58465789
38Choline metabolism in cancer_Homo sapiens_hsa052311.57718400
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.57570977
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.57288881
41Bile secretion_Homo sapiens_hsa049761.55337573
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.54168057
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54029130
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.52274490
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.52001975
46Arginine biosynthesis_Homo sapiens_hsa002201.51902180
47PPAR signaling pathway_Homo sapiens_hsa033201.49938535
48RNA transport_Homo sapiens_hsa030131.45370324
49Retinol metabolism_Homo sapiens_hsa008301.45317586
50Base excision repair_Homo sapiens_hsa034101.43683091
51beta-Alanine metabolism_Homo sapiens_hsa004101.42277641
52Fatty acid biosynthesis_Homo sapiens_hsa000611.39749947
53Histidine metabolism_Homo sapiens_hsa003401.39099482
54Tyrosine metabolism_Homo sapiens_hsa003501.34942877
55Glycosaminoglycan degradation_Homo sapiens_hsa005311.32711355
56Peroxisome_Homo sapiens_hsa041461.32592371
57VEGF signaling pathway_Homo sapiens_hsa043701.31923759
58Pentose and glucuronate interconversions_Homo sapiens_hsa000401.30788458
59Renal cell carcinoma_Homo sapiens_hsa052111.26768719
60Caffeine metabolism_Homo sapiens_hsa002321.23429888
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.21571444
62Endometrial cancer_Homo sapiens_hsa052131.20940164
63Propanoate metabolism_Homo sapiens_hsa006401.19360318
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19271038
65Adherens junction_Homo sapiens_hsa045201.15402197
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15199906
67mTOR signaling pathway_Homo sapiens_hsa041501.11269806
68Chemical carcinogenesis_Homo sapiens_hsa052041.10261222
69Glycerolipid metabolism_Homo sapiens_hsa005611.10218865
70FoxO signaling pathway_Homo sapiens_hsa040681.09562018
71Cysteine and methionine metabolism_Homo sapiens_hsa002701.09298577
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.09169015
73Insulin secretion_Homo sapiens_hsa049111.07748051
74Hippo signaling pathway_Homo sapiens_hsa043901.07494705
75ABC transporters_Homo sapiens_hsa020101.07044746
76Thyroid cancer_Homo sapiens_hsa052161.06536722
77Non-small cell lung cancer_Homo sapiens_hsa052231.00866634
78Long-term depression_Homo sapiens_hsa047301.00837795
79One carbon pool by folate_Homo sapiens_hsa006701.00254330
80Pyruvate metabolism_Homo sapiens_hsa006201.00097270
81Fatty acid elongation_Homo sapiens_hsa000620.99712250
82Glucagon signaling pathway_Homo sapiens_hsa049220.95996129
83Renin secretion_Homo sapiens_hsa049240.95955798
84Thyroid hormone synthesis_Homo sapiens_hsa049180.93021675
85Starch and sucrose metabolism_Homo sapiens_hsa005000.90326458
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89844820
87Ras signaling pathway_Homo sapiens_hsa040140.89400678
88Arginine and proline metabolism_Homo sapiens_hsa003300.89289470
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.87540637
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87470383
91Mismatch repair_Homo sapiens_hsa034300.85965144
92DNA replication_Homo sapiens_hsa030300.85539725
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.85308621
94Chronic myeloid leukemia_Homo sapiens_hsa052200.85017207
95Insulin resistance_Homo sapiens_hsa049310.84941116
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83241573
97Nucleotide excision repair_Homo sapiens_hsa034200.80972075
98Carbon metabolism_Homo sapiens_hsa012000.80156648
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.80070476
100Notch signaling pathway_Homo sapiens_hsa043300.79016162
101Biosynthesis of amino acids_Homo sapiens_hsa012300.78743094
102Small cell lung cancer_Homo sapiens_hsa052220.78419465
1032-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76731597
104Sphingolipid metabolism_Homo sapiens_hsa006000.76250064
105Prion diseases_Homo sapiens_hsa050200.75094202
106Lysine degradation_Homo sapiens_hsa003100.74503011
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71851820
108Pentose phosphate pathway_Homo sapiens_hsa000300.70977675
109Bladder cancer_Homo sapiens_hsa052190.70198768
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68343113
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68183916
112ErbB signaling pathway_Homo sapiens_hsa040120.67687968
113Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66152509
114Hepatitis B_Homo sapiens_hsa051610.63612553
115Fat digestion and absorption_Homo sapiens_hsa049750.62315489
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62254498
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60563940
118Glioma_Homo sapiens_hsa052140.60318683
119Cocaine addiction_Homo sapiens_hsa050300.60151786
120Pancreatic secretion_Homo sapiens_hsa049720.59688176
121Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59456255
122Estrogen signaling pathway_Homo sapiens_hsa049150.57334465
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57296581
124MAPK signaling pathway_Homo sapiens_hsa040100.55806739
125HTLV-I infection_Homo sapiens_hsa051660.55077864
126RNA polymerase_Homo sapiens_hsa030200.55053885
127Prostate cancer_Homo sapiens_hsa052150.54831839
128Circadian entrainment_Homo sapiens_hsa047130.53357658
129Wnt signaling pathway_Homo sapiens_hsa043100.52285929
130Selenocompound metabolism_Homo sapiens_hsa004500.51284118
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50225904
132mRNA surveillance pathway_Homo sapiens_hsa030150.49384315
133Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49275927
134Salivary secretion_Homo sapiens_hsa049700.49199819
135Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.48814106
136Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47840312
137Serotonergic synapse_Homo sapiens_hsa047260.47692689
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.47679665
139Inositol phosphate metabolism_Homo sapiens_hsa005620.47384810
140Herpes simplex infection_Homo sapiens_hsa051680.46755581
141Type II diabetes mellitus_Homo sapiens_hsa049300.45640535
142Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45453359
143Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45437498
144Adipocytokine signaling pathway_Homo sapiens_hsa049200.45285225
145cAMP signaling pathway_Homo sapiens_hsa040240.45233385
146Hedgehog signaling pathway_Homo sapiens_hsa043400.42260264
147Arachidonic acid metabolism_Homo sapiens_hsa005900.42120105
148Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41477595
149Pathways in cancer_Homo sapiens_hsa052000.41028251
150Long-term potentiation_Homo sapiens_hsa047200.40281841
151Glutamatergic synapse_Homo sapiens_hsa047240.39777159
152Melanoma_Homo sapiens_hsa052180.38571274
153Vitamin digestion and absorption_Homo sapiens_hsa049770.38540527
154Vascular smooth muscle contraction_Homo sapiens_hsa042700.38261330
155Oxytocin signaling pathway_Homo sapiens_hsa049210.33191505
156TNF signaling pathway_Homo sapiens_hsa046680.32189365
157Shigellosis_Homo sapiens_hsa051310.32058742
158Platelet activation_Homo sapiens_hsa046110.29004896
159Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25559894
160Basal cell carcinoma_Homo sapiens_hsa052170.24773941
161AMPK signaling pathway_Homo sapiens_hsa041520.24021175
162Rap1 signaling pathway_Homo sapiens_hsa040150.23111736
163Gap junction_Homo sapiens_hsa045400.22643569
164Jak-STAT signaling pathway_Homo sapiens_hsa046300.22456646
165Folate biosynthesis_Homo sapiens_hsa007900.21480979
166Tight junction_Homo sapiens_hsa045300.20777198
167Purine metabolism_Homo sapiens_hsa002300.17801878
168Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17539391
169NOD-like receptor signaling pathway_Homo sapiens_hsa046210.15041711
170Insulin signaling pathway_Homo sapiens_hsa049100.15031377
171Epstein-Barr virus infection_Homo sapiens_hsa051690.14344061

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