ZBED4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.12360678
2nuclear pore complex assembly (GO:0051292)4.98756373
3nuclear pore organization (GO:0006999)4.80829344
4protein localization to kinetochore (GO:0034501)4.65841557
5mitotic nuclear envelope disassembly (GO:0007077)4.23916621
6nucleosome disassembly (GO:0006337)4.20805405
7protein-DNA complex disassembly (GO:0032986)4.20805405
8DNA strand elongation involved in DNA replication (GO:0006271)4.20608145
9protein localization to chromosome, centromeric region (GO:0071459)4.19437030
10mitotic sister chromatid cohesion (GO:0007064)4.19335200
11mitotic chromosome condensation (GO:0007076)4.17892828
12DNA replication initiation (GO:0006270)4.12350554
13DNA strand elongation (GO:0022616)3.99975185
14mitotic metaphase plate congression (GO:0007080)3.95773917
15membrane disassembly (GO:0030397)3.93261703
16nuclear envelope disassembly (GO:0051081)3.93261703
17maturation of SSU-rRNA (GO:0030490)3.93088818
18sister chromatid segregation (GO:0000819)3.91956341
19regulation of histone H3-K9 methylation (GO:0051570)3.90063593
20regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.84317121
21regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.81814845
22DNA replication checkpoint (GO:0000076)3.79234439
23pore complex assembly (GO:0046931)3.79014704
24mitotic sister chromatid segregation (GO:0000070)3.78927125
25telomere maintenance via semi-conservative replication (GO:0032201)3.77120915
26DNA duplex unwinding (GO:0032508)3.75078998
27positive regulation of chromosome segregation (GO:0051984)3.72764308
28DNA geometric change (GO:0032392)3.72387565
29RNA stabilization (GO:0043489)3.68137810
30mRNA stabilization (GO:0048255)3.68137810
31glucocorticoid receptor signaling pathway (GO:0042921)3.67583187
32DNA topological change (GO:0006265)3.67069808
33V(D)J recombination (GO:0033151)3.65848300
34mitotic recombination (GO:0006312)3.62981114
35kinetochore organization (GO:0051383)3.59329069
36negative regulation of histone methylation (GO:0031061)3.59308379
37regulation of NFAT protein import into nucleus (GO:0051532)3.57762498
38DNA replication-dependent nucleosome organization (GO:0034723)3.56322122
39DNA replication-dependent nucleosome assembly (GO:0006335)3.56322122
40telomere maintenance via recombination (GO:0000722)3.53135178
41dosage compensation (GO:0007549)3.53000818
42spliceosomal tri-snRNP complex assembly (GO:0000244)3.48260086
43metaphase plate congression (GO:0051310)3.47469529
44regulation of spindle organization (GO:0090224)3.46029933
45regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.45113774
46regulation of sister chromatid cohesion (GO:0007063)3.43412436
47IMP biosynthetic process (GO:0006188)3.41473759
48negative regulation of mRNA metabolic process (GO:1903312)3.39043050
49monoubiquitinated protein deubiquitination (GO:0035520)3.37342692
50chromatin remodeling at centromere (GO:0031055)3.37070673
51protein localization to chromosome (GO:0034502)3.36522605
52DNA replication-independent nucleosome organization (GO:0034724)3.34699936
53DNA replication-independent nucleosome assembly (GO:0006336)3.34699936
54positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.34412283
55positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.34412283
56positive regulation of mitotic sister chromatid separation (GO:1901970)3.34412283
57CENP-A containing nucleosome assembly (GO:0034080)3.34162058
58nucleobase biosynthetic process (GO:0046112)3.33966462
59chromatin assembly or disassembly (GO:0006333)3.31938268
60translesion synthesis (GO:0019985)3.30965108
61negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.27712360
62DNA conformation change (GO:0071103)3.26718578
63folic acid-containing compound biosynthetic process (GO:0009396)3.26080904
64regulation of RNA export from nucleus (GO:0046831)3.24981501
65pre-miRNA processing (GO:0031054)3.24451692
66chromatin assembly (GO:0031497)3.23640652
67ribosomal small subunit assembly (GO:0000028)3.20167847
68regulation of nucleobase-containing compound transport (GO:0032239)3.19569849
69establishment of chromosome localization (GO:0051303)3.19386342
70nuclear envelope organization (GO:0006998)3.18533342
71regulation of mRNA stability (GO:0043488)3.18189017
72telomere maintenance via telomere lengthening (GO:0010833)3.17292803
73regulation of chromosome segregation (GO:0051983)3.17234149
74negative regulation of RNA splicing (GO:0033119)3.16919214
753-UTR-mediated mRNA stabilization (GO:0070935)3.16785753
76chromosome condensation (GO:0030261)3.16321572
77ATP-dependent chromatin remodeling (GO:0043044)3.16262208
78negative regulation of DNA repair (GO:0045738)3.13717723
79regulation of mitotic spindle organization (GO:0060236)3.13121604
80cytoplasmic mRNA processing body assembly (GO:0033962)3.11144180
81formation of translation preinitiation complex (GO:0001731)3.10775828
82purine nucleobase biosynthetic process (GO:0009113)3.10358249
83attachment of spindle microtubules to kinetochore (GO:0008608)3.09176622
84nucleotide-excision repair, DNA gap filling (GO:0006297)3.07765401
85histone H3-K36 demethylation (GO:0070544)3.06895327
86heterochromatin organization (GO:0070828)3.05907917
87histone exchange (GO:0043486)3.05263087
88IMP metabolic process (GO:0046040)3.03151864
89regulation of DNA endoreduplication (GO:0032875)2.99778333
90regulation of RNA stability (GO:0043487)2.99279216
91histone H2A monoubiquitination (GO:0035518)2.96910807
92kinetochore assembly (GO:0051382)2.95639002
93chromosome segregation (GO:0007059)2.95389061
94positive regulation by host of viral transcription (GO:0043923)2.95335296
95regulation of mitotic metaphase/anaphase transition (GO:0030071)2.94750046
96spindle checkpoint (GO:0031577)2.94670465
97DNA packaging (GO:0006323)2.92620653
98meiotic chromosome segregation (GO:0045132)2.92409180
99RNA localization (GO:0006403)2.92263639
100maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.91762786
101postreplication repair (GO:0006301)2.91686997
102negative regulation of chromosome segregation (GO:0051985)2.91025006
103spindle assembly checkpoint (GO:0071173)2.90045953
104double-strand break repair via nonhomologous end joining (GO:0006303)2.88812260
105non-recombinational repair (GO:0000726)2.88812260
106regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.88630800
107positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.88069379
108telomere maintenance (GO:0000723)2.87606708
109regulation of DNA damage checkpoint (GO:2000001)2.86504509
110negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.85605936
111negative regulation of sister chromatid segregation (GO:0033046)2.85605936
112negative regulation of mitotic sister chromatid separation (GO:2000816)2.85605936
113negative regulation of mitotic sister chromatid segregation (GO:0033048)2.85605936
114telomere organization (GO:0032200)2.85545828
115regulation of centrosome cycle (GO:0046605)2.85224172
116mRNA transport (GO:0051028)2.84167239
117mitotic spindle assembly checkpoint (GO:0007094)2.84124583
118DNA strand renaturation (GO:0000733)2.84009711
119negative regulation of mRNA processing (GO:0050686)2.82325678
120mitotic spindle checkpoint (GO:0071174)2.81219173
121regulation of chromatin binding (GO:0035561)2.81028882
122intracellular estrogen receptor signaling pathway (GO:0030520)2.79769281
123mRNA splicing, via spliceosome (GO:0000398)2.79483505
124RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.79483505
125RNA export from nucleus (GO:0006405)2.75149137
126cellular response to epidermal growth factor stimulus (GO:0071364)2.74758257
127corticosteroid receptor signaling pathway (GO:0031958)2.74456268
128histone H3-K9 methylation (GO:0051567)2.73571150
129regulation of transcription from RNA polymerase I promoter (GO:0006356)2.73464786
130peptidyl-lysine dimethylation (GO:0018027)2.72403462
131paraxial mesoderm development (GO:0048339)2.70752722
132chromatin remodeling (GO:0006338)2.68550750
133regulation of mammary gland epithelial cell proliferation (GO:0033599)2.67912696
134protein export from nucleus (GO:0006611)2.67847343
135stress granule assembly (GO:0034063)2.66042356
136histone H2B ubiquitination (GO:0033523)2.64164507
137planar cell polarity pathway involved in neural tube closure (GO:0090179)2.63727888
138regulation of histone H3-K4 methylation (GO:0051569)2.63388528
139RNA splicing, via transesterification reactions (GO:0000375)2.63287109
140regulation of translational fidelity (GO:0006450)2.62300692
141termination of RNA polymerase II transcription (GO:0006369)2.61588013
142mRNA export from nucleus (GO:0006406)2.61575024
143peptidyl-arginine omega-N-methylation (GO:0035247)2.61362971
144histone H3-K4 methylation (GO:0051568)2.60263714
145DNA synthesis involved in DNA repair (GO:0000731)2.59759354
146positive regulation of gene expression, epigenetic (GO:0045815)2.59679285
147DNA ligation (GO:0006266)2.59085822
148histone H3-K4 trimethylation (GO:0080182)2.57338758
149viral mRNA export from host cell nucleus (GO:0046784)2.55414108
150negative regulation of gene expression, epigenetic (GO:0045814)2.55323526
151mRNA splice site selection (GO:0006376)2.55215083

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.24236871
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.21353319
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.37010950
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.32004713
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.29163518
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.99244294
7MYC_22102868_ChIP-Seq_BL_Human2.64812537
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.50285124
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.33941869
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.32152839
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.22445525
12KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.21274416
13AR_21909140_ChIP-Seq_LNCAP_Human2.14146071
14* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08104938
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.05132989
16E2F7_22180533_ChIP-Seq_HELA_Human10.3990910
17* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.94276668
18CIITA_25753668_ChIP-Seq_RAJI_Human1.89685344
19EST1_17652178_ChIP-ChIP_JURKAT_Human1.89258187
20XRN2_22483619_ChIP-Seq_HELA_Human1.87752212
21* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.82140000
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.76533568
23VDR_23849224_ChIP-Seq_CD4+_Human1.75781423
24* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.75453259
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.72061516
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.71658562
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.69974257
28VDR_21846776_ChIP-Seq_THP-1_Human1.67313801
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.67069021
30KDM2B_26808549_Chip-Seq_DND41_Human1.66316364
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64122202
32KDM5A_27292631_Chip-Seq_BREAST_Human1.63358855
33FOXP3_21729870_ChIP-Seq_TREG_Human1.62039962
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61978217
35TP63_19390658_ChIP-ChIP_HaCaT_Human1.61952941
36GABP_17652178_ChIP-ChIP_JURKAT_Human1.61396354
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.60130191
38* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59209888
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.57398281
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56648127
41* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.53622521
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50736133
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.49909861
44KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.49499574
45KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.49499574
46KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.49499574
47ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.48310600
48TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.47761148
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46313853
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45761903
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45111169
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44331413
53JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.43066580
54GABP_19822575_ChIP-Seq_HepG2_Human1.41535480
55* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41115377
56TTF2_22483619_ChIP-Seq_HELA_Human1.39980172
57* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.37949678
58ELK1_19687146_ChIP-ChIP_HELA_Human1.36889265
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.34221646
60E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33821844
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30933459
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29757717
63DCP1A_22483619_ChIP-Seq_HELA_Human1.28884250
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28777674
65* KDM2B_26808549_Chip-Seq_JURKAT_Human1.28278381
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27952628
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24304425
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23536435
69* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23040425
70ZFP281_27345836_Chip-Seq_ESCs_Mouse1.20319430
71KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19374373
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19072517
73THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18676464
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18387959
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18187028
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17958586
77CHD1_26751641_Chip-Seq_LNCaP_Human1.17529093
78CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15463927
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15093539
80TFEB_21752829_ChIP-Seq_HELA_Human1.14925474
81TP63_17297297_ChIP-ChIP_HaCaT_Human1.14518307
82* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13249136
83DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12805315
84E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.12196746
85STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09964485
86STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09265621
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08197534
88* TCF7_22412390_ChIP-Seq_EML_Mouse1.07879043
89PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07108556
90EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06748551
91NANOG_21062744_ChIP-ChIP_HESCs_Human1.06522301
92ELK3_25401928_ChIP-Seq_HUVEC_Human1.06496810
93* UTX_26944678_Chip-Seq_JUKART_Human1.05717533
94WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05510503
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04443955
96MYB_26560356_Chip-Seq_TH1_Human1.03700548
97* MYB_26560356_Chip-Seq_TH2_Human1.03536795
98ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03487638
99* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03362344
100KDM2B_26808549_Chip-Seq_K562_Human1.03308465
101SPI1_23547873_ChIP-Seq_NB4_Human1.03193351
102* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03170108
103POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02922170
104PKCTHETA_26484144_Chip-Seq_BREAST_Human1.01953829
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99695542
106MAF_26560356_Chip-Seq_TH1_Human0.99424869
107MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.99277782
108TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98545230
109MAF_26560356_Chip-Seq_TH2_Human0.98113569
110SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.97990795
111FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96372499
112* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94872608
113ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93633337
114NCOR1_26117541_ChIP-Seq_K562_Human0.93047759
115YY1_21170310_ChIP-Seq_MESCs_Mouse0.92529007
116P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92528264
117SCL_19346495_ChIP-Seq_HPC-7_Human0.92070859
118* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91777839
119NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.89916341
120RBPJ_22232070_ChIP-Seq_NCS_Mouse0.89010508
121* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.88992271
122SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87207347
123CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86650303
124POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.86134623
125* RUNX1_22412390_ChIP-Seq_EML_Mouse0.85881607
126KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.85556111
127HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.85417100
128IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.85188211
129VDR_24763502_ChIP-Seq_THP-1_Human0.82805703
130ZNF263_19887448_ChIP-Seq_K562_Human0.82796596
131PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.82669467

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.43610207
2MP0003693_abnormal_embryo_hatching4.28771490
3MP0008057_abnormal_DNA_replication4.07691253
4MP0003111_abnormal_nucleus_morphology4.04231860
5MP0003077_abnormal_cell_cycle3.57386413
6MP0004957_abnormal_blastocyst_morpholog3.42483617
7MP0002396_abnormal_hematopoietic_system2.94057922
8MP0010352_gastrointestinal_tract_polyps2.93541743
9MP0002009_preneoplasia2.69609821
10MP0008058_abnormal_DNA_repair2.61647121
11MP0010307_abnormal_tumor_latency2.41992542
12MP0008007_abnormal_cellular_replicative2.40720071
13MP0001730_embryonic_growth_arrest2.31092130
14MP0000350_abnormal_cell_proliferation2.16675308
15MP0004808_abnormal_hematopoietic_stem2.11719688
16MP0003123_paternal_imprinting2.09446662
17MP0004185_abnormal_adipocyte_glucose2.08175209
18MP0008877_abnormal_DNA_methylation2.03806945
19MP0000490_abnormal_crypts_of1.92349149
20MP0008932_abnormal_embryonic_tissue1.90526061
21MP0005076_abnormal_cell_differentiation1.89276485
22MP0005380_embryogenesis_phenotype1.87142987
23MP0001672_abnormal_embryogenesis/_devel1.87142987
24MP0003984_embryonic_growth_retardation1.79123186
25MP0002088_abnormal_embryonic_growth/wei1.76415074
26MP0001545_abnormal_hematopoietic_system1.70501879
27MP0005397_hematopoietic_system_phenotyp1.70501879
28MP0001697_abnormal_embryo_size1.70136021
29MP0003121_genomic_imprinting1.69144201
30MP0003567_abnormal_fetal_cardiomyocyte1.67429682
31MP0009278_abnormal_bone_marrow1.64303359
32MP0003763_abnormal_thymus_physiology1.64077455
33MP0002086_abnormal_extraembryonic_tissu1.59917704
34MP0004197_abnormal_fetal_growth/weight/1.58662211
35MP0002080_prenatal_lethality1.52912185
36MP0002085_abnormal_embryonic_tissue1.51699518
37MP0002019_abnormal_tumor_incidence1.51539932
38MP0002084_abnormal_developmental_patter1.51057887
39MP0000703_abnormal_thymus_morphology1.50937911
40MP0002398_abnormal_bone_marrow1.49609311
41MP0005409_darkened_coat_color1.47532647
42MP0003705_abnormal_hypodermis_morpholog1.41659514
43MP0000313_abnormal_cell_death1.35274900
44MP0006292_abnormal_olfactory_placode1.34067801
45MP0003315_abnormal_perineum_morphology1.33801570
46MP0000428_abnormal_craniofacial_morphol1.31816860
47MP0003786_premature_aging1.28759103
48MP0004233_abnormal_muscle_weight1.28379647
49MP0002722_abnormal_immune_system1.28160666
50MP0009697_abnormal_copulation1.27686391
51MP0000569_abnormal_digit_pigmentation1.27366107
52MP0003890_abnormal_embryonic-extraembry1.26395760
53MP0000689_abnormal_spleen_morphology1.24642113
54MP0003861_abnormal_nervous_system1.24600663
55MP0009333_abnormal_splenocyte_physiolog1.23782279
56MP0005075_abnormal_melanosome_morpholog1.18769262
57MP0002697_abnormal_eye_size1.17790124
58MP0004264_abnormal_extraembryonic_tissu1.15624152
59MP0010030_abnormal_orbit_morphology1.15375778
60MP0006054_spinal_hemorrhage1.15146562
61MP0001286_abnormal_eye_development1.14638244
62MP0001293_anophthalmia1.13425535
63MP0002822_catalepsy1.08880303
64MP0003385_abnormal_body_wall1.07414380
65MP0002429_abnormal_blood_cell1.07034412
66MP0002166_altered_tumor_susceptibility1.06635379
67MP0001835_abnormal_antigen_presentation1.05020661
68MP0003221_abnormal_cardiomyocyte_apopto1.03340115
69MP0003935_abnormal_craniofacial_develop1.02630699
70MP0000716_abnormal_immune_system1.02254636
71MP0001800_abnormal_humoral_immune1.01418446
72MP0001915_intracranial_hemorrhage1.01185924
73MP0009672_abnormal_birth_weight1.00582773
74MP0002081_perinatal_lethality0.96890710
75MP0000432_abnormal_head_morphology0.96442917
76MP0002210_abnormal_sex_determination0.94910771
77MP0003453_abnormal_keratinocyte_physiol0.93491381
78MP0000371_diluted_coat_color0.92440117
79MP0000778_abnormal_nervous_system0.91942694
80MP0003937_abnormal_limbs/digits/tail_de0.91195885
81MP0009053_abnormal_anal_canal0.90747210
82MP0010234_abnormal_vibrissa_follicle0.88212398
83MP0003755_abnormal_palate_morphology0.87606528
84MP0002006_tumorigenesis0.87588859
85MP0005499_abnormal_olfactory_system0.87463120
86MP0005394_taste/olfaction_phenotype0.87463120
87MP0001929_abnormal_gametogenesis0.86464275
88MP0002111_abnormal_tail_morphology0.86442884
89MP0009703_decreased_birth_body0.86136174
90MP0000685_abnormal_immune_system0.85853342
91MP0000537_abnormal_urethra_morphology0.85282649
92MP0005451_abnormal_body_composition0.85225245
93MP0002420_abnormal_adaptive_immunity0.85147133
94MP0001145_abnormal_male_reproductive0.85008587
95MP0001819_abnormal_immune_cell0.84826396
96MP0002075_abnormal_coat/hair_pigmentati0.84636898
97MP0002452_abnormal_antigen_presenting0.84477664
98MP0002092_abnormal_eye_morphology0.84362705
99MP0004381_abnormal_hair_follicle0.83933618
100MP0002098_abnormal_vibrissa_morphology0.81519728
101MP0003942_abnormal_urinary_system0.81317104
102MP0001849_ear_inflammation0.79985260
103MP0005384_cellular_phenotype0.79459629
104MP0000733_abnormal_muscle_development0.78545427
105MP0005501_abnormal_skin_physiology0.78380543
106MP0002116_abnormal_craniofacial_bone0.78153443
107MP0002405_respiratory_system_inflammati0.78096834
108MP0005174_abnormal_tail_pigmentation0.78007711
109MP0005621_abnormal_cell_physiology0.77412242
110MP0000465_gastrointestinal_hemorrhage0.77110505
111MP0003566_abnormal_cell_adhesion0.76812268
112MP0003303_peritoneal_inflammation0.76364667
113MP0001216_abnormal_epidermal_layer0.76197954
114MP0000477_abnormal_intestine_morphology0.75383103
115MP0002114_abnormal_axial_skeleton0.74262751
116MP0003091_abnormal_cell_migration0.73971355
117MP0001188_hyperpigmentation0.73842050
118MP0000579_abnormal_nail_morphology0.72336848
119MP0010630_abnormal_cardiac_muscle0.72149792
120MP0000377_abnormal_hair_follicle0.72010984
121MP0002938_white_spotting0.71906502
122MP0002925_abnormal_cardiovascular_devel0.71859202
123MP0002233_abnormal_nose_morphology0.70984056
124MP0000653_abnormal_sex_gland0.70694368
125MP0010155_abnormal_intestine_physiology0.70396421
126MP0002095_abnormal_skin_pigmentation0.69248610
127MP0003300_gastrointestinal_ulcer0.68237090
128MP0001340_abnormal_eyelid_morphology0.67127917
129MP0002877_abnormal_melanocyte_morpholog0.65565601
130MP0000858_altered_metastatic_potential0.64880099
131MP0000358_abnormal_cell_content/0.64812456
132MP0005671_abnormal_response_to0.64750404
133MP0002723_abnormal_immune_serum0.64017573
134MP0008770_decreased_survivor_rate0.63217553
135MP0003787_abnormal_imprinting0.62744263
136MP0003119_abnormal_digestive_system0.61761679
137MP0003943_abnormal_hepatobiliary_system0.60747721
138MP0005023_abnormal_wound_healing0.60712134
139MP0001186_pigmentation_phenotype0.59266269
140MP0003115_abnormal_respiratory_system0.59067482

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)3.45872910
2Chromsome breakage (HP:0040012)3.42748442
3Ependymoma (HP:0002888)3.39835486
4High anterior hairline (HP:0009890)3.31799758
5Abnormality of chromosome stability (HP:0003220)3.28912092
6Volvulus (HP:0002580)3.23330383
7Selective tooth agenesis (HP:0001592)3.13971339
8Abnormality of the fingertips (HP:0001211)3.03777453
9Medulloblastoma (HP:0002885)3.01220584
10Chromosomal breakage induced by crosslinking agents (HP:0003221)2.98076783
11Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.90433571
12Short 4th metacarpal (HP:0010044)2.90433571
13Increased nuchal translucency (HP:0010880)2.85116959
14Patellar aplasia (HP:0006443)2.80640031
15Proximal placement of thumb (HP:0009623)2.78593261
16Deviation of the thumb (HP:0009603)2.77736420
17Abnormality of DNA repair (HP:0003254)2.76831250
18Reticulocytopenia (HP:0001896)2.71920879
19Abnormal number of incisors (HP:0011064)2.69677763
20Myelodysplasia (HP:0002863)2.65337560
21Colon cancer (HP:0003003)2.64182223
22Oral leukoplakia (HP:0002745)2.62880721
23Prominent nose (HP:0000448)2.62498674
24Thoracic kyphosis (HP:0002942)2.59598635
25Aplasia/Hypoplasia of the patella (HP:0006498)2.57909990
26Squamous cell carcinoma (HP:0002860)2.57015521
27Cutaneous melanoma (HP:0012056)2.56677769
28Cortical dysplasia (HP:0002539)2.56211182
29Impulsivity (HP:0100710)2.55125119
30Abnormality of the anterior horn cell (HP:0006802)2.53189996
31Degeneration of anterior horn cells (HP:0002398)2.53189996
32B lymphocytopenia (HP:0010976)2.52969551
33Abnormality of B cell number (HP:0010975)2.52969551
34Abnormality of cells of the erythroid lineage (HP:0012130)2.52103793
35Hepatoblastoma (HP:0002884)2.51106077
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.49374048
37Deep palmar crease (HP:0006191)2.47076011
38Thrombocytosis (HP:0001894)2.45689684
39IgM deficiency (HP:0002850)2.44755300
40Abnormal number of erythroid precursors (HP:0012131)2.44660474
41Meckel diverticulum (HP:0002245)2.44544893
42Recurrent viral infections (HP:0004429)2.43085068
43Lymphoma (HP:0002665)2.43084995
44Ectopic kidney (HP:0000086)2.41497136
45High pitched voice (HP:0001620)2.40595436
46Basal cell carcinoma (HP:0002671)2.39524478
47Nephroblastoma (Wilms tumor) (HP:0002667)2.39155727
48Facial hemangioma (HP:0000329)2.37815900
49Vertebral arch anomaly (HP:0008438)2.37261783
50Abnormality of the thoracic spine (HP:0100711)2.37107321
51Astrocytoma (HP:0009592)2.35215649
52Abnormality of the astrocytes (HP:0100707)2.35215649
53Skull defect (HP:0001362)2.34631056
54Abnormality of the preputium (HP:0100587)2.34216691
55Cafe-au-lait spot (HP:0000957)2.32806182
56Abnormality of the ileum (HP:0001549)2.32773573
57Long eyelashes (HP:0000527)2.32482648
58Rhabdomyosarcoma (HP:0002859)2.32475843
59Broad distal phalanx of finger (HP:0009836)2.29322056
60Cutis marmorata (HP:0000965)2.26959977
61Asymmetry of the thorax (HP:0001555)2.25650113
62Abnormality of the distal phalanx of the thumb (HP:0009617)2.23382956
63Duodenal stenosis (HP:0100867)2.20374979
64Small intestinal stenosis (HP:0012848)2.20374979
65Esophageal atresia (HP:0002032)2.19328517
66Agnosia (HP:0010524)2.18600466
67Embryonal renal neoplasm (HP:0011794)2.16271373
68Acute myeloid leukemia (HP:0004808)2.13964987
69Long palpebral fissure (HP:0000637)2.13571929
70Thyroiditis (HP:0100646)2.13201064
71Absent thumb (HP:0009777)2.11808170
72Trigonocephaly (HP:0000243)2.11205963
73T lymphocytopenia (HP:0005403)2.10728168
74Neoplasm of striated muscle (HP:0009728)2.10374713
75Abnormality of the carotid arteries (HP:0005344)2.07867745
76Amaurosis fugax (HP:0100576)2.07249477
77Atresia of the external auditory canal (HP:0000413)2.07012846
78Missing ribs (HP:0000921)2.06547196
79Progressive external ophthalmoplegia (HP:0000590)2.04808708
80Combined immunodeficiency (HP:0005387)2.03208021
81Abnormality of chromosome segregation (HP:0002916)2.02443748
82Generalized hypotonia (HP:0001290)2.01742579
83Aplastic anemia (HP:0001915)2.01317319
84Broad thumb (HP:0011304)2.01271664
85Bone marrow hypocellularity (HP:0005528)2.00472292
86Glioma (HP:0009733)2.00280287
87Obsessive-compulsive behavior (HP:0000722)1.99791330
88Disproportionate tall stature (HP:0001519)1.99132527
8911 pairs of ribs (HP:0000878)1.98238002
90Viral hepatitis (HP:0006562)1.97167918
91Hyperacusis (HP:0010780)1.96158604
92Breast hypoplasia (HP:0003187)1.95600261
93Germ cell neoplasia (HP:0100728)1.95491286
94Deep philtrum (HP:0002002)1.95138011
95Papillary thyroid carcinoma (HP:0002895)1.93961144
96Abnormality of the 4th metacarpal (HP:0010012)1.93365325
97Embryonal neoplasm (HP:0002898)1.93319295
98Sloping forehead (HP:0000340)1.91663946
99Pointed chin (HP:0000307)1.91509037
100Long clavicles (HP:0000890)1.91124958
101Cellular immunodeficiency (HP:0005374)1.90073607
102Spina bifida occulta (HP:0003298)1.88770396
103Capillary hemangiomas (HP:0005306)1.87483278
104Overlapping toe (HP:0001845)1.86504638
105Abnormality of T cell number (HP:0011839)1.86106670
106IgG deficiency (HP:0004315)1.85869473
107Neoplasm of the pancreas (HP:0002894)1.85672862
108Malignant gastrointestinal tract tumors (HP:0006749)1.85496564
109Gastrointestinal carcinoma (HP:0002672)1.85496564
110Acute lymphatic leukemia (HP:0006721)1.85222310
111Abnormality of the labia minora (HP:0012880)1.84300023
112Panhypogammaglobulinemia (HP:0003139)1.84082289
113Broad phalanges of the hand (HP:0009768)1.82976825
114Premature graying of hair (HP:0002216)1.82684472
115Tracheoesophageal fistula (HP:0002575)1.82647938
116Neoplasm of the oral cavity (HP:0100649)1.82141334
117Heterotopia (HP:0002282)1.81499433
118Severe combined immunodeficiency (HP:0004430)1.81350701
119Hypoplasia of the thymus (HP:0000778)1.80531955
120Abnormality of the calcaneus (HP:0008364)1.79834942
121Poikiloderma (HP:0001029)1.79260528
122Abnormality of T cells (HP:0002843)1.78089594
123Milia (HP:0001056)1.76767373
124Abnormality of the duodenum (HP:0002246)1.75499495
125Shoulder girdle muscle weakness (HP:0003547)1.75347767
126Uterine leiomyosarcoma (HP:0002891)1.75103785
127Leiomyosarcoma (HP:0100243)1.75103785
128Eosinophilia (HP:0001880)1.74196594
129Progressive muscle weakness (HP:0003323)1.74047702
130Skin tags (HP:0010609)1.73909710
131Abnormality of the intervertebral disk (HP:0005108)1.73707762
132Abnormality of the columella (HP:0009929)1.73553845
133Aplasia/Hypoplasia of the sternum (HP:0006714)1.73456540
134Flat acetabular roof (HP:0003180)1.73377801
135Abnormal lung lobation (HP:0002101)1.73201787
136Subacute progressive viral hepatitis (HP:0006572)1.71891522
137Sandal gap (HP:0001852)1.71144080
138Transitional cell carcinoma of the bladder (HP:0006740)1.70726229
139Bicuspid aortic valve (HP:0001647)1.70717611
140Clubbing of toes (HP:0100760)1.68414876
141Diastasis recti (HP:0001540)1.67715888
142Broad palm (HP:0001169)1.67201458
143Hypoplasia of the capital femoral epiphysis (HP:0003090)1.67184670
144Broad finger (HP:0001500)1.65569360
145Pelvic girdle muscle weakness (HP:0003749)1.65438450
146Bladder neoplasm (HP:0009725)1.65303860
147Bladder carcinoma (HP:0002862)1.65303860
148Pseudobulbar signs (HP:0002200)1.64318893
149Elfin facies (HP:0004428)1.62900412
150Spinal cord lesions (HP:0100561)1.61085113
151Syringomyelia (HP:0003396)1.61085113
152Anal stenosis (HP:0002025)1.59261018
153Short thumb (HP:0009778)1.58227263
154Supernumerary ribs (HP:0005815)1.57306391

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.49393685
2EEF2K3.35082043
3NEK23.11364809
4SMG12.97648070
5WEE12.91435527
6CDK122.88819419
7PRPF4B2.80288537
8MAP3K102.77526698
9TTK2.67208223
10BUB12.59788022
11ICK2.50041912
12CAMK1D2.28949215
13PKN22.17594354
14SRPK12.10283591
15CAMK1G2.09282729
16RPS6KB21.93321493
17ATR1.86993704
18CDK41.84947367
19PASK1.79661708
20STK101.77949335
21MAP4K11.73210830
22MKNK11.71995916
23SCYL21.70225114
24CLK11.70056578
25ACVR1B1.69931799
26DYRK31.67612789
27PLK11.63266123
28TSSK61.63243358
29MKNK21.62149336
30EIF2AK11.58496015
31AURKB1.55256304
32STK41.53012307
33CDK71.51980684
34STK31.48167062
35MAP3K81.46041163
36CHEK11.39146152
37CHEK21.38251770
38BRSK21.37941874
39PIM11.34675475
40TLK11.32029199
41PLK41.31200842
42NEK11.28012438
43PLK31.27137457
44BRD41.26941494
45CDK61.24379560
46SIK21.14332088
47TYRO31.10153641
48EIF2AK31.08461873
49ATM1.08313813
50TGFBR11.07912268
51FGFR41.07897127
52ZAK1.07842061
53TAF11.05239477
54GRK61.03461002
55TRIB31.03004014
56IRAK21.01886482
57FLT31.01326732
58MELK1.00627101
59RPS6KA41.00214438
60MAP3K60.99260282
61MAP3K140.94468811
62LRRK20.93981476
63CDK20.93775697
64MAP2K30.91524561
65ALK0.89010874
66VRK10.88544225
67PAK40.86491096
68BRSK10.85530124
69PRKD30.80263488
70EPHB20.79004288
71PBK0.77728467
72TESK20.76157404
73MTOR0.75610929
74LATS10.74192346
75PDGFRA0.73246398
76SIK10.72626459
77KSR10.72506326
78MARK30.71261478
79CSF1R0.71003089
80BTK0.70553928
81CDK10.68946258
82FGFR30.66888303
83MAPK100.62706160
84AURKA0.61668020
85CDK90.61167655
86CDK80.59974132
87PNCK0.59614336
88ZAP700.59146880
89RPS6KA10.58716253
90RPS6KA20.58601500
91PTK60.57610816
92RET0.56708708
93CDK30.56668705
94PAK20.55128064
95EIF2AK20.54871489
96NME20.53136326
97CSNK2A20.51670442
98MAP2K20.51372052
99GSK3B0.51101044
100BRAF0.50818182
101YES10.48996569
102HIPK20.47393781
103NEK90.47378861
104TYK20.45636313
105CCNB10.45183983
106RPS6KB10.45028070
107CSNK1D0.43520058
108MATK0.42122575
109MAP3K50.41565201
110NLK0.40971293
111DYRK20.40750029
112PRKDC0.40535273
113LATS20.40230629
114CSNK2A10.39478850
115MAPK140.38367142
116PIM20.37457103
117CDK11A0.37127214
118SGK30.37091080
119MARK20.36964359
120AKT20.36420161
121TAOK10.35977352
122JAK30.35759720
123SYK0.35120929
124RAF10.35103719
125CDK150.34931735
126TTN0.33090104
127RPS6KL10.32601703
128RPS6KC10.32601703
129ERBB30.31051466
130MAPK110.30606208
131RPS6KA60.29465869
132PAK10.29046751
133AKT10.28442194
134NUAK10.28165918
135STK38L0.27872349
136DYRK1B0.27519862
137STK240.27181314
138EPHA20.27011621

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.56569794
2Mismatch repair_Homo sapiens_hsa034303.73482087
3Cell cycle_Homo sapiens_hsa041103.09334204
4Base excision repair_Homo sapiens_hsa034103.01994716
5Spliceosome_Homo sapiens_hsa030403.00709882
6RNA transport_Homo sapiens_hsa030132.98136315
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.93434215
8Homologous recombination_Homo sapiens_hsa034402.78081472
9Non-homologous end-joining_Homo sapiens_hsa034502.56771104
10One carbon pool by folate_Homo sapiens_hsa006702.52467256
11Nucleotide excision repair_Homo sapiens_hsa034202.32049829
12Fanconi anemia pathway_Homo sapiens_hsa034602.20125863
13mRNA surveillance pathway_Homo sapiens_hsa030152.15093008
14RNA polymerase_Homo sapiens_hsa030201.94899996
15Systemic lupus erythematosus_Homo sapiens_hsa053221.89010199
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88921947
17Ribosome_Homo sapiens_hsa030101.82043566
18p53 signaling pathway_Homo sapiens_hsa041151.75002253
19RNA degradation_Homo sapiens_hsa030181.65554405
20Pyrimidine metabolism_Homo sapiens_hsa002401.63318808
21Basal transcription factors_Homo sapiens_hsa030221.49717516
22Viral carcinogenesis_Homo sapiens_hsa052031.49642530
23Herpes simplex infection_Homo sapiens_hsa051681.34765748
24Primary immunodeficiency_Homo sapiens_hsa053401.33967059
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.31421588
26ErbB signaling pathway_Homo sapiens_hsa040121.30667147
27Epstein-Barr virus infection_Homo sapiens_hsa051691.28341781
28Renal cell carcinoma_Homo sapiens_hsa052111.28160377
29Antigen processing and presentation_Homo sapiens_hsa046121.27782581
30MicroRNAs in cancer_Homo sapiens_hsa052061.24340311
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.21233128
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19952443
33Chronic myeloid leukemia_Homo sapiens_hsa052201.18373619
34Small cell lung cancer_Homo sapiens_hsa052221.17965263
35Glioma_Homo sapiens_hsa052141.15829399
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.15736819
37VEGF signaling pathway_Homo sapiens_hsa043701.10842806
38Proteasome_Homo sapiens_hsa030501.08611359
39Colorectal cancer_Homo sapiens_hsa052101.08149334
40HTLV-I infection_Homo sapiens_hsa051661.07602436
41Oocyte meiosis_Homo sapiens_hsa041141.06633504
42Thyroid cancer_Homo sapiens_hsa052161.03529871
43Transcriptional misregulation in cancer_Homo sapiens_hsa052021.02427554
44Prolactin signaling pathway_Homo sapiens_hsa049170.97152424
45Wnt signaling pathway_Homo sapiens_hsa043100.94136068
46Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92192772
47Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91380493
48Hepatitis B_Homo sapiens_hsa051610.90118183
49Hedgehog signaling pathway_Homo sapiens_hsa043400.87797801
50mTOR signaling pathway_Homo sapiens_hsa041500.87577050
51Pentose phosphate pathway_Homo sapiens_hsa000300.85941908
52Choline metabolism in cancer_Homo sapiens_hsa052310.81090114
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.80874239
54Inositol phosphate metabolism_Homo sapiens_hsa005620.80305953
55B cell receptor signaling pathway_Homo sapiens_hsa046620.80267268
56Measles_Homo sapiens_hsa051620.79175623
57Non-small cell lung cancer_Homo sapiens_hsa052230.78712156
58Notch signaling pathway_Homo sapiens_hsa043300.78588394
59Viral myocarditis_Homo sapiens_hsa054160.78517331
60Lysine degradation_Homo sapiens_hsa003100.78355932
61Acute myeloid leukemia_Homo sapiens_hsa052210.76559016
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75122762
63Alcoholism_Homo sapiens_hsa050340.74985737
64Purine metabolism_Homo sapiens_hsa002300.74651143
65Selenocompound metabolism_Homo sapiens_hsa004500.74285059
66Apoptosis_Homo sapiens_hsa042100.72130233
67Pancreatic cancer_Homo sapiens_hsa052120.70177822
68Melanoma_Homo sapiens_hsa052180.69376959
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68831544
70Insulin signaling pathway_Homo sapiens_hsa049100.65388212
71Endometrial cancer_Homo sapiens_hsa052130.65286226
72Adherens junction_Homo sapiens_hsa045200.64978383
73Legionellosis_Homo sapiens_hsa051340.64961167
74Biosynthesis of amino acids_Homo sapiens_hsa012300.64754351
75Axon guidance_Homo sapiens_hsa043600.64520226
76Prostate cancer_Homo sapiens_hsa052150.64049041
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.63882749
78Estrogen signaling pathway_Homo sapiens_hsa049150.63631288
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62972844
80Hematopoietic cell lineage_Homo sapiens_hsa046400.62910196
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61199725
82HIF-1 signaling pathway_Homo sapiens_hsa040660.61127416
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60195044
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59704244
85Influenza A_Homo sapiens_hsa051640.59551492
86Hepatitis C_Homo sapiens_hsa051600.57639164
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56984282
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.56116003
89Steroid biosynthesis_Homo sapiens_hsa001000.55190470
90TGF-beta signaling pathway_Homo sapiens_hsa043500.55095592
91Hippo signaling pathway_Homo sapiens_hsa043900.54702663
92Basal cell carcinoma_Homo sapiens_hsa052170.54437658
93N-Glycan biosynthesis_Homo sapiens_hsa005100.54414477
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53395541
95Leishmaniasis_Homo sapiens_hsa051400.52938266
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.52600587
97Shigellosis_Homo sapiens_hsa051310.52094340
98Melanogenesis_Homo sapiens_hsa049160.51626410
99Gap junction_Homo sapiens_hsa045400.51277948
100T cell receptor signaling pathway_Homo sapiens_hsa046600.50596959
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.50162759
102Pathways in cancer_Homo sapiens_hsa052000.48412716
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48221013
104FoxO signaling pathway_Homo sapiens_hsa040680.47828815
105Toxoplasmosis_Homo sapiens_hsa051450.46884307
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.45570358
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.45245722
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45144859
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44178084
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43106543
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43043485
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.40566885
113Proteoglycans in cancer_Homo sapiens_hsa052050.39494364
114Bladder cancer_Homo sapiens_hsa052190.39052755
115Cysteine and methionine metabolism_Homo sapiens_hsa002700.38220274
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37410339
117Drug metabolism - other enzymes_Homo sapiens_hsa009830.34028678
118Vitamin B6 metabolism_Homo sapiens_hsa007500.32768935
119Osteoclast differentiation_Homo sapiens_hsa043800.31498238
120Toll-like receptor signaling pathway_Homo sapiens_hsa046200.25558017
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.25358493
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25091813
123Carbon metabolism_Homo sapiens_hsa012000.23909045
124AMPK signaling pathway_Homo sapiens_hsa041520.23676470
125Renin-angiotensin system_Homo sapiens_hsa046140.23477213

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