ZBED5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is unusual in that its coding sequence is mostly derived from Charlie-like DNA transposon; however, it does not appear to be an active DNA transposon as it is not flanked by terminal inverted repeats. The encoded protein is conserved among the mammalian Laurasiatheria branch. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.66444832
2neural tube formation (GO:0001841)4.23744060
3transcription elongation from RNA polymerase III promoter (GO:0006385)4.03123546
4termination of RNA polymerase III transcription (GO:0006386)4.03123546
5DNA methylation involved in gamete generation (GO:0043046)4.02533522
6piRNA metabolic process (GO:0034587)3.98114805
7behavioral response to nicotine (GO:0035095)3.98056753
8nucleobase catabolic process (GO:0046113)3.81150244
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.76738530
10regulation of nuclear cell cycle DNA replication (GO:0033262)3.63223108
11microtubule depolymerization (GO:0007019)3.62443749
12protein K6-linked ubiquitination (GO:0085020)3.58322349
13epithelial cilium movement (GO:0003351)3.55806020
14DNA double-strand break processing (GO:0000729)3.49484665
15presynaptic membrane assembly (GO:0097105)3.47432345
16establishment of integrated proviral latency (GO:0075713)3.40051589
17DNA deamination (GO:0045006)3.39831832
18central nervous system myelination (GO:0022010)3.39498558
19axon ensheathment in central nervous system (GO:0032291)3.39498558
20transcription elongation from RNA polymerase I promoter (GO:0006362)3.39296636
21somite development (GO:0061053)3.38976086
22RNA capping (GO:0036260)3.32895844
237-methylguanosine RNA capping (GO:0009452)3.32895844
24mRNA splice site selection (GO:0006376)3.32054886
25head development (GO:0060322)3.31107781
26maturation of SSU-rRNA (GO:0030490)3.30691786
27axoneme assembly (GO:0035082)3.27719807
28male meiosis (GO:0007140)3.24561937
297-methylguanosine mRNA capping (GO:0006370)3.24199581
30regulation of cilium movement (GO:0003352)3.23603676
31lateral sprouting from an epithelium (GO:0060601)3.21162245
32spliceosomal snRNP assembly (GO:0000387)3.19764052
33kinetochore assembly (GO:0051382)3.16659141
34prenylation (GO:0097354)3.16522567
35protein prenylation (GO:0018342)3.16522567
36DNA strand renaturation (GO:0000733)3.16278175
37limb bud formation (GO:0060174)3.13181152
38fucose catabolic process (GO:0019317)3.10463978
39L-fucose metabolic process (GO:0042354)3.10463978
40L-fucose catabolic process (GO:0042355)3.10463978
41telomere maintenance via telomerase (GO:0007004)3.09418416
42protein neddylation (GO:0045116)3.09396346
43forebrain neuron differentiation (GO:0021879)3.09153446
44regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.08491300
45chromatin remodeling at centromere (GO:0031055)3.07823114
46termination of RNA polymerase I transcription (GO:0006363)3.07706601
47negative regulation of DNA-dependent DNA replication (GO:2000104)3.07269876
48cilium organization (GO:0044782)3.07039768
49cilium morphogenesis (GO:0060271)3.06624042
50proteasome assembly (GO:0043248)3.06512396
51preassembly of GPI anchor in ER membrane (GO:0016254)3.04048760
52protein localization to cilium (GO:0061512)3.04045822
53female gonad development (GO:0008585)3.03506704
54replication fork processing (GO:0031297)3.02983502
55ribosomal small subunit biogenesis (GO:0042274)3.01097743
56regulation of telomere maintenance (GO:0032204)3.00499826
57cilium assembly (GO:0042384)3.00189127
58microtubule polymerization or depolymerization (GO:0031109)2.99085578
59CENP-A containing nucleosome assembly (GO:0034080)2.98426944
60negative regulation of translation, ncRNA-mediated (GO:0040033)2.97800594
61regulation of translation, ncRNA-mediated (GO:0045974)2.97800594
62negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.97800594
63keratinocyte development (GO:0003334)2.97514615
64positive regulation of mitochondrial fission (GO:0090141)2.96272044
65protein K11-linked deubiquitination (GO:0035871)2.94577149
66kinetochore organization (GO:0051383)2.94488077
67axonemal dynein complex assembly (GO:0070286)2.92412096
68ribosomal large subunit biogenesis (GO:0042273)2.91304570
69transcription from RNA polymerase I promoter (GO:0006360)2.89977468
70histone H4-K12 acetylation (GO:0043983)2.88535803
71transcription-coupled nucleotide-excision repair (GO:0006283)2.88503431
72presynaptic membrane organization (GO:0097090)2.87508549
73telomere maintenance via telomere lengthening (GO:0010833)2.87280112
74rRNA processing (GO:0006364)2.87238177
75transcription initiation from RNA polymerase I promoter (GO:0006361)2.86597038
76rRNA modification (GO:0000154)2.86297490
77inositol phosphate catabolic process (GO:0071545)2.83517655
78DNA ligation (GO:0006266)2.81814759
79cilium movement (GO:0003341)2.81043824
80DNA replication initiation (GO:0006270)2.79684564
81nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.79141200
82positive regulation of oligodendrocyte differentiation (GO:0048714)2.77657226
83activated T cell proliferation (GO:0050798)2.77616135
84exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.77392219
85DNA strand elongation involved in DNA replication (GO:0006271)2.76986966
86rRNA metabolic process (GO:0016072)2.76983816
87regulation of telomere maintenance via telomerase (GO:0032210)2.76916364
88DNA replication checkpoint (GO:0000076)2.76438303
89rRNA catabolic process (GO:0016075)2.76156241
90olfactory bulb development (GO:0021772)2.76104695
91maturation of 5.8S rRNA (GO:0000460)2.75271184
92telomere maintenance via semi-conservative replication (GO:0032201)2.74541128
93cornea development in camera-type eye (GO:0061303)2.73057657
94DNA strand elongation (GO:0022616)2.72061511
95tRNA modification (GO:0006400)2.71756292
96neuron cell-cell adhesion (GO:0007158)2.71426046
97GPI anchor metabolic process (GO:0006505)2.70348976
98ribonucleoprotein complex biogenesis (GO:0022613)2.69755733
99chaperone-mediated protein transport (GO:0072321)2.69668697
100establishment of protein localization to Golgi (GO:0072600)2.68486377
101intraciliary transport (GO:0042073)2.67761851
102pseudouridine synthesis (GO:0001522)2.67075492
103DNA alkylation (GO:0006305)2.66855931
104DNA methylation (GO:0006306)2.66855931
105rRNA methylation (GO:0031167)2.66762800
106histone exchange (GO:0043486)2.66422450
107male sex determination (GO:0030238)2.66265457
108histone H3-K9 methylation (GO:0051567)2.65505460
109recombinational repair (GO:0000725)2.65256482
110tRNA processing (GO:0008033)2.65165859
111ubiquinone metabolic process (GO:0006743)2.65102823
112regulation of development, heterochronic (GO:0040034)2.64623155
113RNA methylation (GO:0001510)2.64415231
114RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.64006104
115tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.64006104
116RNA-dependent DNA replication (GO:0006278)2.63737596
117chromosome organization involved in meiosis (GO:0070192)2.63561295
118double-strand break repair via homologous recombination (GO:0000724)2.62765357
119synaptonemal complex assembly (GO:0007130)2.62526626
120DNA synthesis involved in DNA repair (GO:0000731)2.62069460
121monoubiquitinated protein deubiquitination (GO:0035520)2.61847957
122DNA integration (GO:0015074)2.61685841
123spliceosomal complex assembly (GO:0000245)2.61595661
124negative regulation of telomere maintenance (GO:0032205)2.59830597
125establishment of protein localization to mitochondrial membrane (GO:0090151)2.59305747
126magnesium ion transport (GO:0015693)2.59210920
127dentate gyrus development (GO:0021542)2.58932727
128DNA-templated transcription, elongation (GO:0006354)2.58820959
129establishment of viral latency (GO:0019043)2.58456632
130regulation of meiosis I (GO:0060631)2.57588386
131synapsis (GO:0007129)2.57295844
132GTP biosynthetic process (GO:0006183)2.57132983
133centriole replication (GO:0007099)2.56897822
134tRNA methylation (GO:0030488)2.56851089
135inositol phosphate dephosphorylation (GO:0046855)2.56676559
136phosphorylated carbohydrate dephosphorylation (GO:0046838)2.56676559
137centriole assembly (GO:0098534)2.55806864
138reciprocal DNA recombination (GO:0035825)2.55242727
139reciprocal meiotic recombination (GO:0007131)2.55242727
140meiotic chromosome segregation (GO:0045132)2.55203127
141DNA-templated transcription, termination (GO:0006353)2.55123859
142neuron fate determination (GO:0048664)2.54944476
143cilium or flagellum-dependent cell motility (GO:0001539)2.54243419
144regulation of collateral sprouting (GO:0048670)2.54201933
145ncRNA metabolic process (GO:0034660)2.54043407
146photoreceptor cell maintenance (GO:0045494)2.53894700
147nonmotile primary cilium assembly (GO:0035058)2.53763362
148otic vesicle formation (GO:0030916)2.53077895
149negative regulation of DNA recombination (GO:0045910)2.52765079
150regulation of helicase activity (GO:0051095)2.52721549
151regulation of timing of cell differentiation (GO:0048505)2.52619031
152kidney morphogenesis (GO:0060993)2.50591539
153synaptonemal complex organization (GO:0070193)2.50064734
154histone H2A acetylation (GO:0043968)2.49880934
155telomere maintenance via recombination (GO:0000722)2.49392781
156regulation of mitotic spindle checkpoint (GO:1903504)2.48237372
157regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.48237372
158positive regulation of meiosis (GO:0045836)2.48116518
159DNA replication-independent nucleosome assembly (GO:0006336)2.48101515
160DNA replication-independent nucleosome organization (GO:0034724)2.48101515
161pancreas development (GO:0031016)2.47899810
162microtubule anchoring (GO:0034453)2.47809453
163RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.47491626
164single strand break repair (GO:0000012)2.47421251
165gamma-aminobutyric acid transport (GO:0015812)2.46385163
166organelle disassembly (GO:1903008)2.43629796
167protein targeting to Golgi (GO:0000042)2.40206119
168regulation of action potential (GO:0098900)2.40013917
169spinal cord motor neuron differentiation (GO:0021522)2.37920693
170appendage development (GO:0048736)2.37872855
171limb development (GO:0060173)2.37872855
172polyol catabolic process (GO:0046174)2.37067760
173respiratory chain complex IV assembly (GO:0008535)2.36742883
174cellular component assembly involved in morphogenesis (GO:0010927)2.36738569
175ubiquinone biosynthetic process (GO:0006744)2.36369061
176central nervous system projection neuron axonogenesis (GO:0021952)2.36194071
177tachykinin receptor signaling pathway (GO:0007217)2.33642952
178histone H3-K4 trimethylation (GO:0080182)2.32690718
179embryonic epithelial tube formation (GO:0001838)2.32627788
180anterograde synaptic vesicle transport (GO:0048490)2.32018446
181DNA demethylation (GO:0080111)2.30510506
182detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.28359760
183behavioral response to ethanol (GO:0048149)2.27993052
184indolalkylamine metabolic process (GO:0006586)2.27611921
185cell differentiation in spinal cord (GO:0021515)2.27467086

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.22995309
2ZNF274_21170338_ChIP-Seq_K562_Hela3.22325511
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.19619650
4EZH2_22144423_ChIP-Seq_EOC_Human3.02365657
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.84586163
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.58911442
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.54889442
8GBX2_23144817_ChIP-Seq_PC3_Human2.54571106
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.51322086
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.50916488
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.31982623
12POU5F1_16153702_ChIP-ChIP_HESCs_Human2.13775922
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.11059902
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.09469078
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.06613831
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.04511833
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02946957
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.02890618
19RNF2_27304074_Chip-Seq_NSC_Mouse1.99299074
20CBX2_27304074_Chip-Seq_ESCs_Mouse1.98569266
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.96530481
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.95091781
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91475355
24E2F4_17652178_ChIP-ChIP_JURKAT_Human1.91208319
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.91138821
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.88402472
27TP63_19390658_ChIP-ChIP_HaCaT_Human1.82737084
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81595629
29TAF15_26573619_Chip-Seq_HEK293_Human1.78630840
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.74751637
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.73340354
32ELK1_19687146_ChIP-ChIP_HELA_Human1.72928873
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.68534670
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67865083
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67645396
36ER_23166858_ChIP-Seq_MCF-7_Human1.67266540
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.66478033
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.65054293
39FUS_26573619_Chip-Seq_HEK293_Human1.63859309
40VDR_22108803_ChIP-Seq_LS180_Human1.62347783
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.62066119
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61487037
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.60359224
44KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.59571423
45KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.59571423
46KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.59571423
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.57689203
48CBP_20019798_ChIP-Seq_JUKART_Human1.57689203
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.57683919
50IRF1_19129219_ChIP-ChIP_H3396_Human1.57402693
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56768977
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55956419
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.55732960
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.52344646
55MYC_18358816_ChIP-ChIP_MESCs_Mouse1.51579235
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.48136072
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46785462
58* SMAD4_21799915_ChIP-Seq_A2780_Human1.45771909
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45242923
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44248956
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43557083
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42612255
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41095103
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41013349
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41013349
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.40843242
67STAT3_23295773_ChIP-Seq_U87_Human1.40333337
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38232268
69BCAT_22108803_ChIP-Seq_LS180_Human1.36807203
70AR_25329375_ChIP-Seq_VCAP_Human1.36699636
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.35276744
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34569149
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31321306
74POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30631094
75MYC_18940864_ChIP-ChIP_HL60_Human1.30336369
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.30256108
77EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.30195034
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29538380
79EWS_26573619_Chip-Seq_HEK293_Human1.29419425
80TCF4_23295773_ChIP-Seq_U87_Human1.29393920
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28859051
82SUZ12_18555785_Chip-Seq_ESCs_Mouse1.28647904
83BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28207898
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27011352
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.26315601
86JARID2_20064375_ChIP-Seq_MESCs_Mouse1.26163264
87FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.25639292
88EZH2_27304074_Chip-Seq_ESCs_Mouse1.25607899
89E2F1_18555785_Chip-Seq_ESCs_Mouse1.25013109
90CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24495399
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24126603
92TP53_22573176_ChIP-Seq_HFKS_Human1.23774827
93STAT3_18555785_Chip-Seq_ESCs_Mouse1.23014689
94NMYC_18555785_Chip-Seq_ESCs_Mouse1.21148084
95P300_18555785_Chip-Seq_ESCs_Mouse1.20742341
96RUNX2_22187159_ChIP-Seq_PCA_Human1.20098610
97YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19826889
98PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19814779
99FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.18994382
100* TCF4_22108803_ChIP-Seq_LS180_Human1.17424851
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.16863390
102THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16859491
103HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16814768
104NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16716452
105FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.16132053
106KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15935855
107* TTF2_22483619_ChIP-Seq_HELA_Human1.15796258
108SOX2_16153702_ChIP-ChIP_HESCs_Human1.14763052
109GATA1_26923725_Chip-Seq_HPCs_Mouse1.14739669
110CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14446970
111* P300_19829295_ChIP-Seq_ESCs_Human1.13700547
112P53_22387025_ChIP-Seq_ESCs_Mouse1.12935607
113CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12901044
114CMYC_18555785_Chip-Seq_ESCs_Mouse1.12370717
115RUNX1_27457419_Chip-Seq_LIVER_Mouse1.12349808
116FOXP3_21729870_ChIP-Seq_TREG_Human1.11821547
117EED_16625203_ChIP-ChIP_MESCs_Mouse1.11115642
118* VDR_23849224_ChIP-Seq_CD4+_Human1.10963092
119ELF1_17652178_ChIP-ChIP_JURKAT_Human1.10552097
120KLF4_18555785_Chip-Seq_ESCs_Mouse1.10283991
121RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10129343
122FLI1_21867929_ChIP-Seq_TH2_Mouse1.09936694
123GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09825437
124PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09801321
125KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08096859
126PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07058976
127SOX2_18555785_Chip-Seq_ESCs_Mouse1.06940748
128SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06145898
129TAL1_26923725_Chip-Seq_HPCs_Mouse1.06075540
130ZFX_18555785_Chip-Seq_ESCs_Mouse1.05541785
131OCT4_18555785_Chip-Seq_ESCs_Mouse1.05149228
132RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04461534
133* NANOG_19829295_ChIP-Seq_ESCs_Human1.03937745
134* SOX2_19829295_ChIP-Seq_ESCs_Human1.03937745
135AR_21572438_ChIP-Seq_LNCaP_Human1.03858249
136CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03055270
137IGF1R_20145208_ChIP-Seq_DFB_Human1.02492721
138CRX_20693478_ChIP-Seq_RETINA_Mouse1.02257169
139NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.02240637
140ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01908409
141REST_21632747_ChIP-Seq_MESCs_Mouse1.01569309
142POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01074627
143NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00443128
144FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99224799
145PRDM14_20953172_ChIP-Seq_ESCs_Human0.98855988
146SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98714403
147* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94735042
148OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94075527

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.33501359
2MP0006292_abnormal_olfactory_placode3.99127949
3MP0000566_synostosis3.97058628
4MP0008877_abnormal_DNA_methylation3.50011609
5MP0000569_abnormal_digit_pigmentation3.17270213
6MP0008057_abnormal_DNA_replication2.88742192
7MP0001188_hyperpigmentation2.82284863
8MP0005423_abnormal_somatic_nervous2.78517908
9MP0003880_abnormal_central_pattern2.56141815
10MP0008058_abnormal_DNA_repair2.49554665
11MP0004381_abnormal_hair_follicle2.33632811
12MP0002163_abnormal_gland_morphology2.29985007
13MP0002102_abnormal_ear_morphology2.26395350
14MP0005409_darkened_coat_color2.17893191
15MP0001986_abnormal_taste_sensitivity2.17454316
16MP0004133_heterotaxia2.17161442
17MP0005379_endocrine/exocrine_gland_phen1.95038403
18MP0002638_abnormal_pupillary_reflex1.94176785
19MP0003938_abnormal_ear_development1.92483103
20MP0001984_abnormal_olfaction1.89358645
21MP0010094_abnormal_chromosome_stability1.86916014
22MP0003693_abnormal_embryo_hatching1.84255306
23MP0006276_abnormal_autonomic_nervous1.83314280
24MP0009379_abnormal_foot_pigmentation1.76542023
25MP0001529_abnormal_vocalization1.76255893
26MP0002653_abnormal_ependyma_morphology1.70188604
27MP0004142_abnormal_muscle_tone1.68227701
28MP0003941_abnormal_skin_development1.67214131
29MP0002928_abnormal_bile_duct1.65447258
30MP0003111_abnormal_nucleus_morphology1.64321473
31MP0002210_abnormal_sex_determination1.63759971
32MP0002751_abnormal_autonomic_nervous1.51723973
33MP0002249_abnormal_larynx_morphology1.51720926
34MP0002938_white_spotting1.51537857
35MP0000778_abnormal_nervous_system1.51373815
36MP0010030_abnormal_orbit_morphology1.50053446
37MP0008932_abnormal_embryonic_tissue1.47822257
38MP0002837_dystrophic_cardiac_calcinosis1.45070161
39MP0004742_abnormal_vestibular_system1.44750475
40MP0002822_catalepsy1.44557705
41MP0002009_preneoplasia1.44260636
42MP0004885_abnormal_endolymph1.44046023
43MP0006072_abnormal_retinal_apoptosis1.39672328
44MP0003890_abnormal_embryonic-extraembry1.38036522
45MP0000049_abnormal_middle_ear1.35517651
46MP0003121_genomic_imprinting1.34787914
47MP0000372_irregular_coat_pigmentation1.32349993
48MP0003786_premature_aging1.30447227
49MP0001929_abnormal_gametogenesis1.28239276
50MP0004147_increased_porphyrin_level1.28162497
51MP0000026_abnormal_inner_ear1.27575000
52MP0005174_abnormal_tail_pigmentation1.27508858
53MP0000631_abnormal_neuroendocrine_gland1.27454009
54MP0003119_abnormal_digestive_system1.26468696
55MP0001145_abnormal_male_reproductive1.25853224
56MP0003567_abnormal_fetal_cardiomyocyte1.24738998
57MP0001486_abnormal_startle_reflex1.24431410
58MP0003123_paternal_imprinting1.23807437
59MP0000516_abnormal_urinary_system1.23134283
60MP0005367_renal/urinary_system_phenotyp1.23134283
61MP0003937_abnormal_limbs/digits/tail_de1.22718174
62MP0001905_abnormal_dopamine_level1.22337289
63MP0001346_abnormal_lacrimal_gland1.21356268
64MP0000427_abnormal_hair_cycle1.21285040
65MP0003077_abnormal_cell_cycle1.20130288
66MP0000653_abnormal_sex_gland1.19242968
67MP0008995_early_reproductive_senescence1.18552360
68MP0002138_abnormal_hepatobiliary_system1.17710526
69MP0003718_maternal_effect1.17043728
70MP0002095_abnormal_skin_pigmentation1.16880148
71MP0003698_abnormal_male_reproductive1.16802820
72MP0001485_abnormal_pinna_reflex1.16296861
73MP0004957_abnormal_blastocyst_morpholog1.16248796
74MP0002277_abnormal_respiratory_mucosa1.15618299
75MP0002184_abnormal_innervation1.14396009
76MP0005253_abnormal_eye_physiology1.13388400
77MP0002272_abnormal_nervous_system1.12867512
78MP0002132_abnormal_respiratory_system1.10366457
79MP0000955_abnormal_spinal_cord1.09863355
80MP0005075_abnormal_melanosome_morpholog1.09829841
81MP0008789_abnormal_olfactory_epithelium1.08982386
82MP0005551_abnormal_eye_electrophysiolog1.08260736
83MP0005645_abnormal_hypothalamus_physiol1.06212585
84MP0003011_delayed_dark_adaptation1.06063823
85MP0008007_abnormal_cellular_replicative1.05134370
86MP0003315_abnormal_perineum_morphology1.03295094
87MP0002067_abnormal_sensory_capabilities1.00267694
88MP0001963_abnormal_hearing_physiology0.99556729
89MP0002752_abnormal_somatic_nervous0.99349101
90MP0000762_abnormal_tongue_morphology0.98503034
91MP0002063_abnormal_learning/memory/cond0.98391300
92MP0005195_abnormal_posterior_eye0.96244603
93MP0001286_abnormal_eye_development0.95725086
94MP0003787_abnormal_imprinting0.95332520
95MP0002557_abnormal_social/conspecific_i0.95086706
96MP0004215_abnormal_myocardial_fiber0.94330891
97MP0003861_abnormal_nervous_system0.94081530
98MP0005171_absent_coat_pigmentation0.92500177
99MP0003122_maternal_imprinting0.92029416
100MP0005248_abnormal_Harderian_gland0.91786886
101MP0004197_abnormal_fetal_growth/weight/0.90479620
102MP0005084_abnormal_gallbladder_morpholo0.90246489
103MP0009250_abnormal_appendicular_skeleto0.90145002
104MP0009745_abnormal_behavioral_response0.89552475
105MP0003755_abnormal_palate_morphology0.89489930
106MP0004043_abnormal_pH_regulation0.89289769
107MP0002233_abnormal_nose_morphology0.89283813
108MP0002572_abnormal_emotion/affect_behav0.87891721
109MP0004270_analgesia0.87216058
110MP0004924_abnormal_behavior0.86555506
111MP0005386_behavior/neurological_phenoty0.86555506
112MP0001968_abnormal_touch/_nociception0.82370244
113MP0001502_abnormal_circadian_rhythm0.81335906
114MP0002736_abnormal_nociception_after0.81310608
115MP0001177_atelectasis0.81117352
116MP0005394_taste/olfaction_phenotype0.80068173
117MP0005499_abnormal_olfactory_system0.80068173
118MP0001293_anophthalmia0.79672179
119MP0005220_abnormal_exocrine_pancreas0.79315831
120MP0002734_abnormal_mechanical_nocicepti0.79051464
121MP0002116_abnormal_craniofacial_bone0.78922759
122MP0005646_abnormal_pituitary_gland0.78631285
123MP0000015_abnormal_ear_pigmentation0.78584511
124MP0009046_muscle_twitch0.78417393
125MP0002152_abnormal_brain_morphology0.78311795
126MP0002735_abnormal_chemical_nociception0.78270081
127MP0005410_abnormal_fertilization0.76879419
128MP0002234_abnormal_pharynx_morphology0.76853975
129MP0005389_reproductive_system_phenotype0.76593587
130MP0002282_abnormal_trachea_morphology0.76056810
131MP0002876_abnormal_thyroid_physiology0.75943270
132MP0003385_abnormal_body_wall0.75869324
133MP0005391_vision/eye_phenotype0.75417970
134MP0005257_abnormal_intraocular_pressure0.74832817
135MP0002882_abnormal_neuron_morphology0.74431690
136MP0003635_abnormal_synaptic_transmissio0.74331244
137MP0005451_abnormal_body_composition0.74215990
138MP0004145_abnormal_muscle_electrophysio0.73529786

Predicted human phenotypes

RankGene SetZ-score
1Duplicated collecting system (HP:0000081)4.79843790
2Chromsome breakage (HP:0040012)4.62411195
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.30561582
4Abnormality of the renal collecting system (HP:0004742)4.10658566
5Pancreatic cysts (HP:0001737)3.81358708
6Abnormality of midbrain morphology (HP:0002418)3.55179513
7Molar tooth sign on MRI (HP:0002419)3.55179513
8Abnormal ciliary motility (HP:0012262)3.53529996
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.33221307
10Abnormality of the renal medulla (HP:0100957)3.32395779
11Septo-optic dysplasia (HP:0100842)3.30642849
12Duplication of thumb phalanx (HP:0009942)3.29229061
13Supernumerary spleens (HP:0009799)3.12667390
14Abnormal respiratory motile cilium physiology (HP:0012261)3.03121452
15Abnormality of the renal cortex (HP:0011035)2.93467176
16Absent radius (HP:0003974)2.92091014
17Abnormal respiratory epithelium morphology (HP:0012253)2.88622837
18Abnormal respiratory motile cilium morphology (HP:0005938)2.88622837
19Chronic hepatic failure (HP:0100626)2.82887977
20Absent/shortened dynein arms (HP:0200106)2.79224606
21Dynein arm defect of respiratory motile cilia (HP:0012255)2.79224606
22Absent forearm bone (HP:0003953)2.79120650
23Aplasia involving forearm bones (HP:0009822)2.79120650
24Nephrogenic diabetes insipidus (HP:0009806)2.75064332
25Abnormality of the labia minora (HP:0012880)2.73781289
26Aplasia/Hypoplasia of the fovea (HP:0008060)2.70725402
27Hypoplasia of the fovea (HP:0007750)2.70725402
28Abnormal sex determination (HP:0012244)2.65674186
29Sex reversal (HP:0012245)2.65674186
30Absent septum pellucidum (HP:0001331)2.60880632
31Anomalous pulmonary venous return (HP:0010772)2.59202997
32Volvulus (HP:0002580)2.58227961
33Reticulocytopenia (HP:0001896)2.56710167
34Optic nerve hypoplasia (HP:0000609)2.56405766
35Abnormality of the septum pellucidum (HP:0007375)2.52718293
36Abnormality of DNA repair (HP:0003254)2.51763376
37Renal cortical cysts (HP:0000803)2.48006534
38Conical tooth (HP:0000698)2.44239079
39Tubular atrophy (HP:0000092)2.43592712
40Vaginal atresia (HP:0000148)2.42432453
41Thyroid-stimulating hormone excess (HP:0002925)2.40168647
42Triphalangeal thumb (HP:0001199)2.38267571
43Colon cancer (HP:0003003)2.37198046
44Hyperglycinemia (HP:0002154)2.35671836
45Asplenia (HP:0001746)2.32498520
46Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.32349471
47Aplasia/Hypoplasia of the tibia (HP:0005772)2.31290137
48Meckel diverticulum (HP:0002245)2.30691358
49Breast hypoplasia (HP:0003187)2.30543021
50Cerebral hypomyelination (HP:0006808)2.27585762
51Abnormality of the pulmonary veins (HP:0011718)2.27064548
52Short tibia (HP:0005736)2.27040308
53Cystic liver disease (HP:0006706)2.25803117
54Absent thumb (HP:0009777)2.24976722
55Abnormality of the preputium (HP:0100587)2.24880947
56Abnormality of the ileum (HP:0001549)2.24471409
57Birth length less than 3rd percentile (HP:0003561)2.24312332
58Preaxial hand polydactyly (HP:0001177)2.23918364
59Hyperventilation (HP:0002883)2.23383348
60Oligodactyly (hands) (HP:0001180)2.23254798
61Tubulointerstitial nephritis (HP:0001970)2.22134881
62Adrenal hypoplasia (HP:0000835)2.21120242
63Aplasia/Hypoplasia of the uvula (HP:0010293)2.19553787
64True hermaphroditism (HP:0010459)2.19390720
65Stomach cancer (HP:0012126)2.18098011
66Hip dysplasia (HP:0001385)2.17667637
67Partial duplication of thumb phalanx (HP:0009944)2.16357874
68Abnormal biliary tract physiology (HP:0012439)2.15896746
69Bile duct proliferation (HP:0001408)2.15896746
70Medial flaring of the eyebrow (HP:0010747)2.14533503
71Concave nail (HP:0001598)2.13548618
72Postaxial hand polydactyly (HP:0001162)2.13259126
73Abnormality of the fovea (HP:0000493)2.12241771
74Lissencephaly (HP:0001339)2.11373261
75Polydipsia (HP:0001959)2.11152322
76Abnormal drinking behavior (HP:0030082)2.11152322
77Nephronophthisis (HP:0000090)2.10262425
78Narrow forehead (HP:0000341)2.08149615
7911 pairs of ribs (HP:0000878)2.08117841
80Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.07993837
81Congenital hepatic fibrosis (HP:0002612)2.07112380
82Drooling (HP:0002307)2.06391013
83Abolished electroretinogram (ERG) (HP:0000550)2.05205189
84Anencephaly (HP:0002323)2.04808589
85Aplasia/Hypoplasia of the spleen (HP:0010451)2.04305378
86Abnormal lung lobation (HP:0002101)2.02834966
87Poor coordination (HP:0002370)2.02400336
88Broad-based gait (HP:0002136)2.01627960
89Hypoplastic pelvis (HP:0008839)2.00612600
90Nephroblastoma (Wilms tumor) (HP:0002667)1.99926733
91Thyroiditis (HP:0100646)1.99776550
92Intestinal atresia (HP:0011100)1.98877594
93Supernumerary bones of the axial skeleton (HP:0009144)1.97324206
94Pancreatic fibrosis (HP:0100732)1.97033989
95Abnormality of permanent molar morphology (HP:0011071)1.96596270
96Abnormality of the dental root (HP:0006486)1.96596270
97Taurodontia (HP:0000679)1.96596270
98Congenital stationary night blindness (HP:0007642)1.96106215
99Parakeratosis (HP:0001036)1.95303220
100Partial duplication of the phalanx of hand (HP:0009999)1.94823275
101Abnormality of molar morphology (HP:0011070)1.94788657
102Abnormality of molar (HP:0011077)1.94788657
103Pendular nystagmus (HP:0012043)1.94784027
104Excessive salivation (HP:0003781)1.93822453
105Abnormality of chromosome stability (HP:0003220)1.93765742
106Specific learning disability (HP:0001328)1.92909397
107Facial cleft (HP:0002006)1.92156772
108Progressive cerebellar ataxia (HP:0002073)1.91535397
109Increased hepatocellular lipid droplets (HP:0006565)1.90182437
110Embryonal renal neoplasm (HP:0011794)1.88823442
111Abnormality of the dental pulp (HP:0006479)1.88543651
112Rhinitis (HP:0012384)1.88218831
113Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.88145775
114Gastrointestinal atresia (HP:0002589)1.88113253
115Abnormal hair whorl (HP:0010721)1.87949842
116Methylmalonic acidemia (HP:0002912)1.87807046
117Ectopic kidney (HP:0000086)1.86939470
118Absent speech (HP:0001344)1.86766979
119Aplasia/Hypoplasia of the tongue (HP:0010295)1.86199142
120Gaze-evoked nystagmus (HP:0000640)1.85613236
121Horseshoe kidney (HP:0000085)1.84950902
122Aplasia cutis congenita (HP:0001057)1.84936422
123Postaxial foot polydactyly (HP:0001830)1.84580431
124Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.84313168
125Long foot (HP:0001833)1.82607151
126Panhypogammaglobulinemia (HP:0003139)1.81764282
127Absent eyebrow (HP:0002223)1.81320758
128Type II lissencephaly (HP:0007260)1.81271478
129Renal agenesis (HP:0000104)1.81085502
130Upper limb muscle weakness (HP:0003484)1.80550426
131Attenuation of retinal blood vessels (HP:0007843)1.79928762
132Sclerocornea (HP:0000647)1.79450169
133Genetic anticipation (HP:0003743)1.79396016
134Growth hormone deficiency (HP:0000824)1.79134204
135Supernumerary ribs (HP:0005815)1.79116732
136Male pseudohermaphroditism (HP:0000037)1.76948744
137Microvesicular hepatic steatosis (HP:0001414)1.76811430
138Renal Fanconi syndrome (HP:0001994)1.76781463
139Gait imbalance (HP:0002141)1.76619791
140Abnormality of abdominal situs (HP:0011620)1.76423458
141Abdominal situs inversus (HP:0003363)1.76423458
142Nasolacrimal duct obstruction (HP:0000579)1.76098807
143Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.75978603
144Aplasia/Hypoplasia of the earlobes (HP:0009906)1.75939009
145Median cleft lip (HP:0000161)1.75338202
146Pachygyria (HP:0001302)1.75156670
147Congenital primary aphakia (HP:0007707)1.74561552
148Medulloblastoma (HP:0002885)1.74519398
149Patellar aplasia (HP:0006443)1.74229696
150Protruding tongue (HP:0010808)1.73684039
151Progressive external ophthalmoplegia (HP:0000590)1.73336710
152Genital tract atresia (HP:0001827)1.73157776
153Short foot (HP:0001773)1.71646435
154Febrile seizures (HP:0002373)1.71553218
155Hepatoblastoma (HP:0002884)1.70507379
156Broad foot (HP:0001769)1.70084210
157Abnormality of the metopic suture (HP:0005556)1.69567839
158Oculomotor apraxia (HP:0000657)1.67514193
159Abnormal rod and cone electroretinograms (HP:0008323)1.66055840
160Tubulointerstitial abnormality (HP:0001969)1.65576858
161Agitation (HP:0000713)1.64649373
162Degeneration of the lateral corticospinal tracts (HP:0002314)1.64634956
163Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.64634956
164Sloping forehead (HP:0000340)1.62050256
165Neonatal respiratory distress (HP:0002643)1.61572127
166Cerebellar dysplasia (HP:0007033)1.61338717
167Abnormality of B cell number (HP:0010975)1.61031143
168Failure to thrive in infancy (HP:0001531)1.60510175
169Dandy-Walker malformation (HP:0001305)1.59779478
170Multicystic kidney dysplasia (HP:0000003)1.59538903
171Furrowed tongue (HP:0000221)1.58792773
172Papilledema (HP:0001085)1.58720002
173Progressive inability to walk (HP:0002505)1.57370113
174Bony spicule pigmentary retinopathy (HP:0007737)1.56391333
175Chorioretinal atrophy (HP:0000533)1.54853991

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.14620387
2CASK3.75910874
3INSRR3.62150939
4SRPK12.91922877
5TRIM282.79454481
6ZAK2.74826310
7TAOK32.70884440
8WEE12.48897711
9MKNK22.46755397
10TLK12.34520710
11STK162.19450552
12MKNK12.18394986
13BUB12.02135551
14CDC71.95212355
15MAP4K21.95116175
16NUAK11.86903057
17MAP2K71.84415297
18ACVR1B1.79232709
19STK38L1.78957052
20ERBB31.77496551
21PINK11.77078558
22GRK71.73264411
23VRK11.72516148
24PBK1.71525735
25IRAK31.67708625
26DYRK21.58944511
27PLK41.56229484
28NME11.53677066
29MAPK131.53356865
30CSNK1G21.52284401
31FGFR21.48761644
32PNCK1.46772657
33IRAK11.42673393
34CSNK1G11.42199540
35NEK61.41075301
36TNIK1.39733007
37MARK11.33567470
38DYRK31.30611872
39CDK71.30461094
40TTK1.30280503
41BMPR21.29617504
42PAK31.29397058
43PLK31.24816059
44BMPR1B1.22388613
45ATR1.18816692
46PLK11.17899656
47CSNK1A1L1.17586055
48BRSK21.14361082
49IRAK21.14097326
50SIK21.12840855
51NTRK31.12590530
52EPHA31.11783601
53PRPF4B1.11199339
54TEC1.10321876
55CHEK21.08391501
56EIF2AK21.07364392
57STK241.04523169
58BCR1.02929005
59MAP4K11.02220254
60AURKA1.00454081
61AKT30.99065207
62CDK80.98316854
63EPHA40.97622790
64TXK0.95765107
65MAP2K40.94941949
66CDK30.94795764
67CAMKK20.92403720
68NTRK20.91156595
69PKN10.89931394
70TAOK20.89011715
71OBSCN0.88968607
72OXSR10.88929199
73RPS6KA40.88380253
74TGFBR10.87259576
75TSSK60.85114360
76RPS6KA50.84719954
77MUSK0.84600267
78PASK0.81633322
79BRD40.76654870
80CHEK10.75038632
81IRAK40.74865525
82ADRBK20.74054600
83ATM0.73150089
84STK390.72968666
85LATS10.70292693
86PLK20.68678802
87MAPK150.68533878
88YES10.65567940
89STK30.65139636
90DYRK1B0.64722551
91WNK40.64398382
92BRAF0.63134012
93BTK0.62823549
94BLK0.60193330
95UHMK10.59628130
96CSNK2A20.59567826
97MAP3K40.58601815
98PRKCE0.58083628
99PRKCG0.58043959
100CCNB10.57158275
101DYRK1A0.56819043
102NLK0.56451623
103EPHB20.56413203
104ITK0.55663542
105STK110.54540780
106CDK190.54365461
107CAMK2B0.52879053
108MARK30.51462034
109CSNK2A10.51205396
110CSNK1E0.50637289
111BRSK10.50451449
112GRK10.49611742
113CAMK2A0.49001925
114WNK30.48483815
115CDK10.48169545
116NME20.47733932
117SGK2230.47410760
118SGK4940.47410760
119PRKD20.46743755
120MATK0.46442437
121FES0.46388210
122AURKB0.45468874
123PDK20.45221664
124SYK0.45134044
125EIF2AK30.45116060
126LYN0.44460726
127CSNK1D0.43999982
128CDK20.42929621
129PIK3CG0.41616676
130TNK20.41276153
131PIK3CA0.40093263
132PRKCI0.40021334
133CSNK1G30.38136216
134PRKCQ0.38121827
135SGK20.37877328
136NEK20.37783128
137ADRBK10.37443098
138MAPK70.35134849
139KIT0.34719909
140MAP3K60.34227640
141PRKACA0.34074594
142IKBKE0.34034053
143CAMK2D0.32470752
144CSNK1A10.32310085
145MAP2K20.32293478
146EPHA20.31152658

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030203.84285248
2Ribosome_Homo sapiens_hsa030103.29341423
3Homologous recombination_Homo sapiens_hsa034403.25575418
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.19003709
5Fanconi anemia pathway_Homo sapiens_hsa034603.06288044
6DNA replication_Homo sapiens_hsa030302.99567042
7Mismatch repair_Homo sapiens_hsa034302.88127594
8Spliceosome_Homo sapiens_hsa030402.60458375
9Basal transcription factors_Homo sapiens_hsa030222.59057617
10Non-homologous end-joining_Homo sapiens_hsa034502.48253959
11Nucleotide excision repair_Homo sapiens_hsa034202.45540606
12Proteasome_Homo sapiens_hsa030502.20449526
13Pyrimidine metabolism_Homo sapiens_hsa002402.18032759
14Phototransduction_Homo sapiens_hsa047442.06690469
15RNA transport_Homo sapiens_hsa030131.96257532
16Nicotine addiction_Homo sapiens_hsa050331.94908673
17Regulation of autophagy_Homo sapiens_hsa041401.94134151
18Butanoate metabolism_Homo sapiens_hsa006501.87698491
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.83690531
20RNA degradation_Homo sapiens_hsa030181.80467208
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.74278906
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.72683650
23Oxidative phosphorylation_Homo sapiens_hsa001901.71380076
24Base excision repair_Homo sapiens_hsa034101.70441106
25One carbon pool by folate_Homo sapiens_hsa006701.59980436
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.55480532
27Ether lipid metabolism_Homo sapiens_hsa005651.52005767
28Propanoate metabolism_Homo sapiens_hsa006401.51892670
29Primary immunodeficiency_Homo sapiens_hsa053401.50341873
30Huntingtons disease_Homo sapiens_hsa050161.50192891
31mRNA surveillance pathway_Homo sapiens_hsa030151.48338835
32Purine metabolism_Homo sapiens_hsa002301.47365229
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.40078163
34Cell cycle_Homo sapiens_hsa041101.36113032
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30066750
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29509036
37Protein export_Homo sapiens_hsa030601.28721966
38Parkinsons disease_Homo sapiens_hsa050121.27538749
39Nitrogen metabolism_Homo sapiens_hsa009101.16811309
40Peroxisome_Homo sapiens_hsa041461.13307481
41Olfactory transduction_Homo sapiens_hsa047401.10133351
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09764335
43Hedgehog signaling pathway_Homo sapiens_hsa043401.06607819
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05919149
45Basal cell carcinoma_Homo sapiens_hsa052171.04634543
46Linoleic acid metabolism_Homo sapiens_hsa005910.96419675
47Steroid biosynthesis_Homo sapiens_hsa001000.95911787
48Dorso-ventral axis formation_Homo sapiens_hsa043200.94569441
49Folate biosynthesis_Homo sapiens_hsa007900.92462003
50Taste transduction_Homo sapiens_hsa047420.90070013
51Serotonergic synapse_Homo sapiens_hsa047260.89976506
52Alzheimers disease_Homo sapiens_hsa050100.89459255
53Arachidonic acid metabolism_Homo sapiens_hsa005900.86923438
54Sulfur relay system_Homo sapiens_hsa041220.86786009
55Sphingolipid metabolism_Homo sapiens_hsa006000.86412938
56Circadian rhythm_Homo sapiens_hsa047100.83828627
57Autoimmune thyroid disease_Homo sapiens_hsa053200.83247826
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82385766
59Vitamin B6 metabolism_Homo sapiens_hsa007500.79343977
60Systemic lupus erythematosus_Homo sapiens_hsa053220.79072063
61Dopaminergic synapse_Homo sapiens_hsa047280.74588937
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71811962
63Axon guidance_Homo sapiens_hsa043600.70036627
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69735204
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69238896
66Wnt signaling pathway_Homo sapiens_hsa043100.67330529
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66045599
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65895723
69Graft-versus-host disease_Homo sapiens_hsa053320.63856756
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60742809
71p53 signaling pathway_Homo sapiens_hsa041150.59568329
72Epstein-Barr virus infection_Homo sapiens_hsa051690.58040815
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57333045
74Morphine addiction_Homo sapiens_hsa050320.56168995
75Allograft rejection_Homo sapiens_hsa053300.56123100
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56042011
77Alcoholism_Homo sapiens_hsa050340.55696035
78Tryptophan metabolism_Homo sapiens_hsa003800.55683146
79Glutamatergic synapse_Homo sapiens_hsa047240.55557218
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53544523
81Type I diabetes mellitus_Homo sapiens_hsa049400.52963576
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52522784
83Chemical carcinogenesis_Homo sapiens_hsa052040.52362176
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51858778
85Oocyte meiosis_Homo sapiens_hsa041140.50848015
86Retinol metabolism_Homo sapiens_hsa008300.50282507
87Oxytocin signaling pathway_Homo sapiens_hsa049210.50184009
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.50123568
89Cholinergic synapse_Homo sapiens_hsa047250.48239690
90Insulin secretion_Homo sapiens_hsa049110.47006976
91ABC transporters_Homo sapiens_hsa020100.45905141
92Metabolic pathways_Homo sapiens_hsa011000.45098021
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44095508
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43689203
95Renin secretion_Homo sapiens_hsa049240.42829013
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42722506
97Salivary secretion_Homo sapiens_hsa049700.41164963
98Cardiac muscle contraction_Homo sapiens_hsa042600.40670415
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38551949
100Colorectal cancer_Homo sapiens_hsa052100.37667278
101Fatty acid elongation_Homo sapiens_hsa000620.37129455
102Notch signaling pathway_Homo sapiens_hsa043300.36861678
103GABAergic synapse_Homo sapiens_hsa047270.36770086
104Glycerolipid metabolism_Homo sapiens_hsa005610.35922651
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.35582717
106Amphetamine addiction_Homo sapiens_hsa050310.34749521
107Ovarian steroidogenesis_Homo sapiens_hsa049130.34143325
108Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33773984
109Maturity onset diabetes of the young_Homo sapiens_hsa049500.33590700
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33505484
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32857849
112Arginine and proline metabolism_Homo sapiens_hsa003300.32021789
113cAMP signaling pathway_Homo sapiens_hsa040240.31981694
114TGF-beta signaling pathway_Homo sapiens_hsa043500.30882378
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29081722
116Cocaine addiction_Homo sapiens_hsa050300.28532299
117Hippo signaling pathway_Homo sapiens_hsa043900.27799373
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27095599
119Calcium signaling pathway_Homo sapiens_hsa040200.23677926
120Prion diseases_Homo sapiens_hsa050200.21445827
121Long-term depression_Homo sapiens_hsa047300.21221868
122Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.21179764
123Circadian entrainment_Homo sapiens_hsa047130.20360978
124Glutathione metabolism_Homo sapiens_hsa004800.19567257
125Ras signaling pathway_Homo sapiens_hsa040140.17955614
126Melanogenesis_Homo sapiens_hsa049160.17333975
127Vitamin digestion and absorption_Homo sapiens_hsa049770.16854304
128Asthma_Homo sapiens_hsa053100.16133697
129Selenocompound metabolism_Homo sapiens_hsa004500.15559541

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