ZBED6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this transposon-derived intronless gene is a transcriptional repressor that binds to the consensus sequence 5'-GCTCGC-3'. The encoded protein has been shown to repress IGF2 transcription. This gene is located within the first intron of the ZC3H11A gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)4.65578987
2negative regulation of translation, ncRNA-mediated (GO:0040033)4.31942090
3regulation of translation, ncRNA-mediated (GO:0045974)4.31942090
4negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.31942090
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.21176460
6phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.16573003
7embryonic process involved in female pregnancy (GO:0060136)4.07183975
8nuclear pore complex assembly (GO:0051292)3.89907992
9cellular response to ethanol (GO:0071361)3.77011604
10definitive hemopoiesis (GO:0060216)3.64296816
11cytoplasmic mRNA processing body assembly (GO:0033962)3.55649452
12histone H3-K4 trimethylation (GO:0080182)3.51141798
13monoubiquitinated protein deubiquitination (GO:0035520)3.49377996
14regulation of transforming growth factor beta2 production (GO:0032909)3.44087993
15embryonic retina morphogenesis in camera-type eye (GO:0060059)3.41931744
16nuclear pore organization (GO:0006999)3.30894824
17pericardium development (GO:0060039)3.29547738
18regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.29505021
19regulation of establishment of cell polarity (GO:2000114)3.21287637
20lipid translocation (GO:0034204)3.17542457
21phospholipid translocation (GO:0045332)3.17542457
22regulation of DNA endoreduplication (GO:0032875)3.13173281
23iron ion import (GO:0097286)3.11030645
24macroautophagy (GO:0016236)3.11016161
25protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)3.09704500
26neuron projection extension involved in neuron projection guidance (GO:1902284)3.09363432
27axon extension involved in axon guidance (GO:0048846)3.09363432
28COPII vesicle coating (GO:0048208)3.07998401
29pore complex assembly (GO:0046931)3.07732156
30regulation of protein polyubiquitination (GO:1902914)3.00610731
31insulin-like growth factor receptor signaling pathway (GO:0048009)3.00163624
32positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.98782887
33NLS-bearing protein import into nucleus (GO:0006607)2.94974459
34histone H3-K36 demethylation (GO:0070544)2.93397815
35negative regulation of fatty acid transport (GO:2000192)2.91781292
36protein K48-linked deubiquitination (GO:0071108)2.91208136
37hypotonic response (GO:0006971)2.88188177
38lung lobe morphogenesis (GO:0060463)2.87443739
39regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.85724271
40positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.85724271
41regulation of RNA export from nucleus (GO:0046831)2.84792324
42hippo signaling (GO:0035329)2.83304292
43embryonic camera-type eye morphogenesis (GO:0048596)2.80766370
44peptidyl-lysine trimethylation (GO:0018023)2.76561230
45positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.75961491
46regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.75961491
47mesenchymal-epithelial cell signaling (GO:0060638)2.73863738
48cell adhesion mediated by integrin (GO:0033627)2.73474849
49fibroblast migration (GO:0010761)2.73207322
50paraxial mesoderm development (GO:0048339)2.72608116
51regulation of establishment or maintenance of cell polarity (GO:0032878)2.68909994
52histone H3-K4 methylation (GO:0051568)2.68722146
53lateral sprouting from an epithelium (GO:0060601)2.68045747
54I-kappaB phosphorylation (GO:0007252)2.66831713
55regulation of histone H3-K27 methylation (GO:0061085)2.65810431
56coronary vasculature morphogenesis (GO:0060977)2.65326507
57artery development (GO:0060840)2.64989540
58establishment of protein localization to Golgi (GO:0072600)2.64538221
59embryonic eye morphogenesis (GO:0048048)2.64247244
60regulation of pigment cell differentiation (GO:0050932)2.63803685
61plasma membrane repair (GO:0001778)2.63552085
62regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.61928560
63retrograde transport, vesicle recycling within Golgi (GO:0000301)2.58807813
64peptidyl-lysine dimethylation (GO:0018027)2.57584027
65hemidesmosome assembly (GO:0031581)2.52496753
66morphogenesis of an epithelial sheet (GO:0002011)2.52193371
67mesodermal cell differentiation (GO:0048333)2.49067451
68smooth muscle tissue development (GO:0048745)2.49007048
69positive regulation of mRNA catabolic process (GO:0061014)2.48715026
70cell-substrate junction assembly (GO:0007044)2.46870792
71positive regulation of protein import into nucleus, translocation (GO:0033160)2.45757319
72positive regulation of DNA-templated transcription, initiation (GO:2000144)2.45282643
73protein K11-linked deubiquitination (GO:0035871)2.44825186
74hepatocyte apoptotic process (GO:0097284)2.44818188
75interkinetic nuclear migration (GO:0022027)2.44199699
76heart morphogenesis (GO:0003007)2.43755276
77radial glial cell differentiation (GO:0060019)2.42905504
78dosage compensation (GO:0007549)2.41926330
79mesenchymal cell differentiation (GO:0048762)2.41386688
80regulation of chemokine-mediated signaling pathway (GO:0070099)2.41346709
81chondrocyte development (GO:0002063)2.40871695
82endocardial cushion development (GO:0003197)2.39161618
83negative chemotaxis (GO:0050919)2.39048583
84striated muscle atrophy (GO:0014891)2.39008455
85glomerular visceral epithelial cell development (GO:0072015)2.37103927
86glomerular filtration (GO:0003094)2.36751743
87regulation of mRNA catabolic process (GO:0061013)2.36307810
88interleukin-6-mediated signaling pathway (GO:0070102)2.36016593
89positive regulation of developmental pigmentation (GO:0048087)2.35559846
90branching involved in salivary gland morphogenesis (GO:0060445)2.35406138
91corticosteroid receptor signaling pathway (GO:0031958)2.34881861
92protein targeting to Golgi (GO:0000042)2.34252542
93skeletal muscle adaptation (GO:0043501)2.34123740
94cell proliferation involved in metanephros development (GO:0072203)2.33230681
95peptidyl-threonine modification (GO:0018210)2.32866225
96negative regulation of DNA repair (GO:0045738)2.32602266
97positive regulation of mesenchymal cell proliferation (GO:0002053)2.32509346
98glomerular epithelial cell development (GO:0072310)2.31986900
99regulation of nucleobase-containing compound transport (GO:0032239)2.31295322
100collagen fibril organization (GO:0030199)2.30505232
101pathway-restricted SMAD protein phosphorylation (GO:0060389)2.30323547
102peptidyl-threonine phosphorylation (GO:0018107)2.29563935
103pre-miRNA processing (GO:0031054)2.28883829
104positive regulation of SMAD protein import into nucleus (GO:0060391)2.28702304
105desmosome organization (GO:0002934)2.28608656
106negative regulation of complement activation (GO:0045916)2.28585740
107positive regulation of muscle hypertrophy (GO:0014742)2.27949381
108positive regulation of cardiac muscle hypertrophy (GO:0010613)2.27949381
109embryonic hemopoiesis (GO:0035162)2.27941733
110face morphogenesis (GO:0060325)2.27448809
111axis elongation (GO:0003401)2.27406494
112regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.26811255
113retina vasculature morphogenesis in camera-type eye (GO:0061299)2.26456471
114intestinal epithelial cell development (GO:0060576)2.25643227
115regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.25593407
116ER overload response (GO:0006983)2.25270925
117substrate-dependent cell migration (GO:0006929)2.25085729
118skin morphogenesis (GO:0043589)2.25068505
119peptidyl-lysine methylation (GO:0018022)2.24659033
120wound healing, spreading of epidermal cells (GO:0035313)2.24652675
121platelet-derived growth factor receptor signaling pathway (GO:0048008)2.24421448
122detection of molecule of bacterial origin (GO:0032490)2.23696438
123SMAD protein complex assembly (GO:0007183)2.23580714
124negative regulation of anoikis (GO:2000811)2.23444207
125regulation of steroid hormone biosynthetic process (GO:0090030)2.23418775
126early endosome to late endosome transport (GO:0045022)2.23380682
127positive regulation of cardiac muscle cell differentiation (GO:2000727)2.23078038
128renal filtration (GO:0097205)2.21676043
129branching involved in prostate gland morphogenesis (GO:0060442)2.21269944
130regulation of hippo signaling (GO:0035330)2.20592548
131histone-serine phosphorylation (GO:0035404)2.20374339
132face development (GO:0060324)2.19930384
133sequestering of extracellular ligand from receptor (GO:0035581)2.19646261
134regulation of mesenchymal cell proliferation (GO:0010464)2.19465260
135histone H3-K9 demethylation (GO:0033169)2.19149362
136regulation of cardiac muscle hypertrophy (GO:0010611)2.19014930
137Golgi to endosome transport (GO:0006895)2.18456321
138negative regulation of keratinocyte proliferation (GO:0010839)2.18219843
139nucleus localization (GO:0051647)2.18210254
140cell proliferation involved in kidney development (GO:0072111)2.18197711
141histone lysine methylation (GO:0034968)2.17999662
142negative regulation of protein activation cascade (GO:2000258)2.17550758
143regulation of muscle hypertrophy (GO:0014743)2.17345910
144mammary gland epithelial cell proliferation (GO:0033598)2.17095782
145negative regulation of vascular permeability (GO:0043116)2.17074479
146regulation of mitotic spindle organization (GO:0060236)2.16455269
147histone lysine demethylation (GO:0070076)2.16323842
148cellular response to interferon-alpha (GO:0035457)2.13889785
149cell migration involved in sprouting angiogenesis (GO:0002042)2.12480247
150prostate gland growth (GO:0060736)2.11654224
151Notch signaling involved in heart development (GO:0061314)2.11569706
152epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.11507212
153positive regulation of p38MAPK cascade (GO:1900745)2.10687304
154prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.10315707
155mesenchymal cell proliferation (GO:0010463)2.09387782
156somite development (GO:0061053)2.08833253
157cell surface receptor signaling pathway involved in heart development (GO:0061311)2.07854272
158histone H3-K9 methylation (GO:0051567)2.06997390
159negative regulation of DNA-dependent DNA replication (GO:2000104)2.06218983
160mammary gland development (GO:0030879)2.05745574
161dorsal/ventral axis specification (GO:0009950)2.05173933
162head development (GO:0060322)2.05173911
163histone H3-K9 modification (GO:0061647)2.04995199
164embryonic viscerocranium morphogenesis (GO:0048703)2.04888685
165regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.04844992
166genitalia morphogenesis (GO:0035112)2.03512111
167lymph vessel development (GO:0001945)2.02324964

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.31718961
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.13728114
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.11143421
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.10804487
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.78670760
6TP53_16413492_ChIP-PET_HCT116_Human2.65070255
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.47432125
8E2F7_22180533_ChIP-Seq_HELA_Human2.44044965
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.37259655
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.32978942
11ZNF217_24962896_ChIP-Seq_MCF-7_Human2.17723599
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.09619000
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93876316
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.91190398
15TRIM28_21343339_ChIP-Seq_HEK293_Human1.90610804
16CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.85163524
17PIAS1_25552417_ChIP-Seq_VCAP_Human1.83877742
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.82194526
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.74651303
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.73424677
21GBX2_23144817_ChIP-Seq_PC3_Human1.73202336
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70054513
23ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.68754062
24KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.68669990
25RBPJ_22232070_ChIP-Seq_NCS_Mouse1.64237089
26TP63_19390658_ChIP-ChIP_HaCaT_Human1.63530195
27GATA2_21666600_ChIP-Seq_HMVEC_Human1.62277069
28FOXM1_23109430_ChIP-Seq_U2OS_Human1.60061593
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59528201
30FUS_26573619_Chip-Seq_HEK293_Human1.57022600
31TCF4_18268006_ChIP-ChIP_LS174T_Human1.56188468
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.56176649
33BRD4_25478319_ChIP-Seq_HGPS_Human1.54997653
34WT1_19549856_ChIP-ChIP_CCG9911_Human1.54662562
35AHR_22903824_ChIP-Seq_MCF-7_Human1.54648458
36EWS_26573619_Chip-Seq_HEK293_Human1.54026745
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.50001808
38FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.49936748
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49330497
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.49065565
41SOX9_24532713_ChIP-Seq_HFSC_Mouse1.48774609
42ARNT_22903824_ChIP-Seq_MCF-7_Human1.48160649
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47276378
44CJUN_26792858_Chip-Seq_BT549_Human1.45115052
45FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.43798573
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39660039
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38941435
48FOXO3_23340844_ChIP-Seq_DLD1_Human1.38224232
49HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.36810629
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.36311566
51NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32884329
52CTNNB1_20460455_ChIP-Seq_HCT116_Human1.31834703
53TP53_18474530_ChIP-ChIP_U2OS_Human1.31725218
54FOXM1_26456572_ChIP-Seq_MCF-7_Human1.31521825
55NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27101449
56NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27101449
57SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.25753044
58SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.25753044
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24769568
60SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24722547
61PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.24016161
62GATA1_22025678_ChIP-Seq_K562_Human1.23189697
63ISL1_27105846_Chip-Seq_CPCs_Mouse1.22874609
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.21770115
65SMAD4_21799915_ChIP-Seq_A2780_Human1.21672200
66TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20657492
67ER_23166858_ChIP-Seq_MCF-7_Human1.20172142
68STAT3_23295773_ChIP-Seq_U87_Human1.20164177
69ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19871445
70* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19791991
71P300_19829295_ChIP-Seq_ESCs_Human1.18824594
72ESR1_21235772_ChIP-Seq_MCF-7_Human1.17533128
73TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.17435598
74RUNX_20019798_ChIP-Seq_JUKART_Human1.15414073
75CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14841128
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12968352
77FOXA2_19822575_ChIP-Seq_HepG2_Human1.12951028
78TP63_23658742_ChIP-Seq_EP156T_Human1.12274924
79TBX3_20139965_ChIP-Seq_ESCs_Mouse1.12020132
80TBX3_20139965_ChIP-Seq_MESCs_Mouse1.10876837
81SALL4_18804426_ChIP-ChIP_XEN_Mouse1.10863212
82VDR_24787735_ChIP-Seq_THP-1_Human1.10759376
83AR_21572438_ChIP-Seq_LNCaP_Human1.09803291
84EP300_21415370_ChIP-Seq_HL-1_Mouse1.09484220
85RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09098535
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08798426
87NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07841377
88FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07065186
89PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07064186
90IGF1R_20145208_ChIP-Seq_DFB_Human1.06098011
91* NANOG_18555785_Chip-Seq_ESCs_Mouse1.05595952
92GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05555158
93YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05067239
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04356331
95IRF8_22096565_ChIP-ChIP_GC-B_Human1.03385944
96RXR_22108803_ChIP-Seq_LS180_Human1.03184061
97* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03154379
98EZH2_27294783_Chip-Seq_NPCs_Mouse1.02991847
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02806457
100TAF15_26573619_Chip-Seq_HEK293_Human1.02738081
101TCF4_23295773_ChIP-Seq_U87_Human1.02515411
102* E2F1_18555785_Chip-Seq_ESCs_Mouse1.02159725
103SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02036719
104FLI1_27457419_Chip-Seq_LIVER_Mouse1.01654549
105EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01596289
106DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01596229
107SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01348208
108ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01296682
109FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01149584
110ESR1_20079471_ChIP-ChIP_T-47D_Human1.00702608
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00575567
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00575567
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99176815
114BCAT_22108803_ChIP-Seq_LS180_Human0.98056793
115NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97488252
116RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97332005
117SCL_19346495_ChIP-Seq_HPC-7_Human0.95858870
118WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95804888
119FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.95734265
120RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.94786943
121SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94376843
122GATA2_19941826_ChIP-Seq_K562_Human0.94185560
123KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92291832
124SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.91039275
125NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91035973
126AR_21909140_ChIP-Seq_LNCAP_Human0.90635896
127FOXA1_25552417_ChIP-Seq_VCAP_Human0.89950891
128* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88417786
129* CMYC_18555785_Chip-Seq_ESCs_Mouse0.88191209

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.64022614
2MP0000383_abnormal_hair_follicle2.78005911
3MP0005076_abnormal_cell_differentiation2.72321165
4MP0003941_abnormal_skin_development2.40132955
5MP0010678_abnormal_skin_adnexa2.39419700
6MP0005503_abnormal_tendon_morphology2.36482107
7MP0010352_gastrointestinal_tract_polyps2.36226980
8MP0004272_abnormal_basement_membrane2.35311426
9MP0008438_abnormal_cutaneous_collagen2.32290274
10MP0000566_synostosis2.30112950
11MP0003300_gastrointestinal_ulcer2.21957536
12MP0003045_fibrosis2.06813691
13MP0002877_abnormal_melanocyte_morpholog1.97646496
14MP0005275_abnormal_skin_tensile1.94770568
15MP0002009_preneoplasia1.93918865
16MP0009053_abnormal_anal_canal1.88923084
17MP0003705_abnormal_hypodermis_morpholog1.88676394
18MP0001299_abnormal_eye_distance/1.80383127
19MP0004233_abnormal_muscle_weight1.75723269
20MP0003091_abnormal_cell_migration1.74851668
21MP0003566_abnormal_cell_adhesion1.70955329
22MP0009384_cardiac_valve_regurgitation1.67846243
23MP0003828_pulmonary_edema1.67520459
24MP0002006_tumorigenesis1.64703742
25MP0003937_abnormal_limbs/digits/tail_de1.60480080
26MP0010307_abnormal_tumor_latency1.56303156
27MP0006054_spinal_hemorrhage1.53422973
28MP0000733_abnormal_muscle_development1.50737457
29MP0002166_altered_tumor_susceptibility1.50115446
30MP0008057_abnormal_DNA_replication1.49640248
31MP0005257_abnormal_intraocular_pressure1.48321219
32MP0000427_abnormal_hair_cycle1.44922348
33MP0000432_abnormal_head_morphology1.41330537
34MP0001293_anophthalmia1.40467842
35MP0002098_abnormal_vibrissa_morphology1.40410200
36MP0003935_abnormal_craniofacial_develop1.39927970
37MP0003950_abnormal_plasma_membrane1.38942380
38MP0000013_abnormal_adipose_tissue1.37141286
39MP0001879_abnormal_lymphatic_vessel1.36793938
40MP0002396_abnormal_hematopoietic_system1.36360621
41MP0005451_abnormal_body_composition1.34560713
42MP0000462_abnormal_digestive_system1.33929206
43MP0003868_abnormal_feces_composition1.32905284
44MP0000537_abnormal_urethra_morphology1.32504228
45MP0002060_abnormal_skin_morphology1.32348873
46MP0003656_abnormal_erythrocyte_physiolo1.31498730
47MP0003763_abnormal_thymus_physiology1.30430302
48MP0002332_abnormal_exercise_endurance1.30231888
49MP0005023_abnormal_wound_healing1.29977740
50MP0005248_abnormal_Harderian_gland1.29295803
51MP0010234_abnormal_vibrissa_follicle1.28672515
52MP0000767_abnormal_smooth_muscle1.28582994
53MP0003385_abnormal_body_wall1.28572496
54MP0003755_abnormal_palate_morphology1.28542393
55MP0001661_extended_life_span1.28108172
56MP0005171_absent_coat_pigmentation1.25974079
57MP0003890_abnormal_embryonic-extraembry1.21383619
58MP0002697_abnormal_eye_size1.21353457
59MP0005508_abnormal_skeleton_morphology1.19159817
60MP0004197_abnormal_fetal_growth/weight/1.18928603
61MP0000428_abnormal_craniofacial_morphol1.18529722
62MP0009697_abnormal_copulation1.18291191
63MP0003453_abnormal_keratinocyte_physiol1.18179675
64MP0002254_reproductive_system_inflammat1.17793827
65MP0003121_genomic_imprinting1.17075432
66MP0002928_abnormal_bile_duct1.16831887
67MP0001346_abnormal_lacrimal_gland1.16556573
68MP0004134_abnormal_chest_morphology1.15635160
69MP0002092_abnormal_eye_morphology1.15079912
70MP0000003_abnormal_adipose_tissue1.15069543
71MP0000647_abnormal_sebaceous_gland1.14427806
72MP0002108_abnormal_muscle_morphology1.10951812
73MP0005409_darkened_coat_color1.10947819
74MP0004185_abnormal_adipocyte_glucose1.10759841
75MP0010368_abnormal_lymphatic_system1.10427866
76MP0004264_abnormal_extraembryonic_tissu1.09082038
77MP0004084_abnormal_cardiac_muscle1.08755296
78MP0005220_abnormal_exocrine_pancreas1.08375217
79MP0002168_other_aberrant_phenotype1.06834462
80MP0004036_abnormal_muscle_relaxation1.06611143
81MP0009703_decreased_birth_body1.05161191
82MP0002925_abnormal_cardiovascular_devel1.05056214
83MP0004130_abnormal_muscle_cell1.03976255
84MP0005623_abnormal_meninges_morphology1.03564929
85MP0001958_emphysema1.02325088
86MP0000377_abnormal_hair_follicle1.02315616
87MP0000579_abnormal_nail_morphology1.02238246
88MP0008961_abnormal_basal_metabolism1.01873342
89MP0002938_white_spotting1.01438413
90MP0003943_abnormal_hepatobiliary_system1.01333970
91MP0008004_abnormal_stomach_pH1.00910477
92MP0004808_abnormal_hematopoietic_stem1.00885171
93MP0002177_abnormal_outer_ear1.00639091
94MP0005367_renal/urinary_system_phenotyp0.99060297
95MP0000516_abnormal_urinary_system0.99060297
96MP0003191_abnormal_cellular_cholesterol0.98543447
97MP0000371_diluted_coat_color0.98497014
98MP0005083_abnormal_biliary_tract0.98041473
99MP0003115_abnormal_respiratory_system0.97961045
100MP0003787_abnormal_imprinting0.96550734
101MP0002109_abnormal_limb_morphology0.95958253
102MP0001286_abnormal_eye_development0.94460435
103MP0005408_hypopigmentation0.94299965
104MP0005621_abnormal_cell_physiology0.93339256
105MP0002086_abnormal_extraembryonic_tissu0.92158949
106MP0009780_abnormal_chondrocyte_physiolo0.92008710
107MP0003279_aneurysm0.91932255
108MP0004381_abnormal_hair_follicle0.91128137
109MP0002896_abnormal_bone_mineralization0.91048976
110MP0002084_abnormal_developmental_patter0.90689270
111MP0001243_abnormal_dermal_layer0.89447061
112MP0009250_abnormal_appendicular_skeleto0.88875861
113MP0005174_abnormal_tail_pigmentation0.88679482
114MP0002233_abnormal_nose_morphology0.88605998
115MP0005187_abnormal_penis_morphology0.88312279
116MP0002282_abnormal_trachea_morphology0.86852584
117MP0003221_abnormal_cardiomyocyte_apopto0.86280446
118MP0001915_intracranial_hemorrhage0.86122521
119MP0005164_abnormal_response_to0.84911072
120MP0000627_abnormal_mammary_gland0.84609141
121MP0000762_abnormal_tongue_morphology0.83790734
122MP0002128_abnormal_blood_circulation0.83704725
123MP0001340_abnormal_eyelid_morphology0.83186831
124MP0001784_abnormal_fluid_regulation0.79378410
125MP0003252_abnormal_bile_duct0.79290853
126MP0002088_abnormal_embryonic_growth/wei0.79119624
127MP0003984_embryonic_growth_retardation0.77002971
128MP0004947_skin_inflammation0.75665623
129MP0002116_abnormal_craniofacial_bone0.75236220
130MP0002115_abnormal_skeleton_extremities0.74873928
131MP0001191_abnormal_skin_condition0.74498819
132MP0001851_eye_inflammation0.73339753
133MP0000465_gastrointestinal_hemorrhage0.72855497
134MP0001672_abnormal_embryogenesis/_devel0.72034978
135MP0005380_embryogenesis_phenotype0.72034978
136MP0010630_abnormal_cardiac_muscle0.71643194
137MP0004883_abnormal_blood_vessel0.69960106
138MP0009115_abnormal_fat_cell0.69136114
139MP0004087_abnormal_muscle_fiber0.67521038
140MP0000759_abnormal_skeletal_muscle0.67109953
141MP0000015_abnormal_ear_pigmentation0.66531862
142MP0005375_adipose_tissue_phenotype0.65559256
143MP0001175_abnormal_lung_morphology0.62501615

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)3.97221131
2Overgrowth (HP:0001548)3.18722248
3Abnormality of the nasal septum (HP:0000419)3.16843000
4Volvulus (HP:0002580)3.12054778
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.02566227
6Short 4th metacarpal (HP:0010044)3.02566227
7Abnormality of the fingertips (HP:0001211)2.71970953
8Hypoplastic labia majora (HP:0000059)2.70876165
9Lip pit (HP:0100267)2.67339025
10Urethral obstruction (HP:0000796)2.58047523
11Shallow orbits (HP:0000586)2.57423085
12Hypoplastic ischia (HP:0003175)2.53246111
13Thyroid carcinoma (HP:0002890)2.52369639
14Anal stenosis (HP:0002025)2.49993184
15Limited elbow extension (HP:0001377)2.49280790
16Long eyelashes (HP:0000527)2.44723997
17Narrow palate (HP:0000189)2.44448438
18Relative macrocephaly (HP:0004482)2.42015971
19Abnormality of the labia majora (HP:0012881)2.40433181
20Aortic aneurysm (HP:0004942)2.38943840
21Fair hair (HP:0002286)2.37969038
22Abnormality of the left ventricular outflow tract (HP:0011103)2.37869067
23Subaortic stenosis (HP:0001682)2.37869067
24Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.36961136
25Spondylolisthesis (HP:0003302)2.35442727
26Midline defect of the nose (HP:0004122)2.34732233
27Aplasia cutis congenita (HP:0001057)2.33117545
28Abnormality of the ischium (HP:0003174)2.31790684
29Sandal gap (HP:0001852)2.30661418
30Atrophic scars (HP:0001075)2.30187125
31Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.25769515
32Short chin (HP:0000331)2.22652069
33Mitral stenosis (HP:0001718)2.22469118
34Absent frontal sinuses (HP:0002688)2.20722318
35Broad metatarsal (HP:0001783)2.18298695
36Macroorchidism (HP:0000053)2.17520835
37Large earlobe (HP:0009748)2.17384823
38Ankyloglossia (HP:0010296)2.16870565
39Trigonocephaly (HP:0000243)2.13915030
40Asymmetry of the thorax (HP:0001555)2.13024779
41Deep philtrum (HP:0002002)2.12790547
42Persistence of primary teeth (HP:0006335)2.11974105
43Dysmetric saccades (HP:0000641)2.11330378
44Supernumerary ribs (HP:0005815)2.10413337
45Abnormality of the right ventricle (HP:0001707)2.09798650
46Abnormality of the epiphyses of the hand (HP:0005924)2.09776813
47Curly hair (HP:0002212)2.08802057
48Dislocated radial head (HP:0003083)2.05334053
49Neonatal hypoglycemia (HP:0001998)2.04002625
50Broad face (HP:0000283)2.03978181
51Submucous cleft hard palate (HP:0000176)2.03427307
52Aqueductal stenosis (HP:0002410)2.02828981
53Hyperkalemia (HP:0002153)2.01321373
54Menstrual irregularities (HP:0000858)2.00140753
55Ectopic kidney (HP:0000086)1.99090783
56Wormian bones (HP:0002645)1.98641742
57Protrusio acetabuli (HP:0003179)1.98240200
58Cerebral aneurysm (HP:0004944)1.97863131
59Generalized hypopigmentation of hair (HP:0011358)1.97298803
60Oligodontia (HP:0000677)1.96770810
61Abnormality of the incisor (HP:0000676)1.95823369
62Skull defect (HP:0001362)1.95725427
63Subacute progressive viral hepatitis (HP:0006572)1.95557193
64Short nail (HP:0001799)1.93624540
65Cubitus valgus (HP:0002967)1.92709212
66Hypoplasia of the maxilla (HP:0000327)1.91897756
67Broad ribs (HP:0000885)1.91774843
68Hematochezia (HP:0002573)1.91758988
69Abnormality of the 4th metacarpal (HP:0010012)1.90973764
70Vertebral arch anomaly (HP:0008438)1.89911689
71Syringomyelia (HP:0003396)1.89361273
72Spinal cord lesions (HP:0100561)1.89361273
73Flat acetabular roof (HP:0003180)1.89135613
74Coarse hair (HP:0002208)1.89041657
75Acute myeloid leukemia (HP:0004808)1.88998085
76Abnormality of incisor morphology (HP:0011063)1.88306372
77Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.87540739
78Cupped ear (HP:0000378)1.85557846
79Blue irides (HP:0000635)1.85303509
80Abnormality of oral frenula (HP:0000190)1.85142363
81Abnormal number of incisors (HP:0011064)1.85063185
82Abnormality of the radial head (HP:0003995)1.84737336
83Cystic hygroma (HP:0000476)1.84417645
84Thoracolumbar scoliosis (HP:0002944)1.82342516
85Premature rupture of membranes (HP:0001788)1.82315808
86Broad thumb (HP:0011304)1.81840783
87Prostate neoplasm (HP:0100787)1.80689503
88Abnormal foot bone ossification (HP:0010675)1.79434814
89Periodontitis (HP:0000704)1.79010195
90Abnormality of the antihelix (HP:0009738)1.77105637
91Arterial tortuosity (HP:0005116)1.76968731
92Limited hip movement (HP:0008800)1.76098484
93Termporal pattern (HP:0011008)1.75741771
94Insidious onset (HP:0003587)1.75741771
95Oligodactyly (hands) (HP:0001180)1.74878855
96Mitral valve prolapse (HP:0001634)1.74405991
97Vascular tortuosity (HP:0004948)1.74381449
98Mesomelia (HP:0003027)1.74138699
99Short metatarsal (HP:0010743)1.73804520
100Abnormality of secondary sexual hair (HP:0009888)1.72623832
101Abnormality of the axillary hair (HP:0100134)1.72623832
102Osteolytic defects of the phalanges of the hand (HP:0009771)1.72391803
103Osteolytic defects of the hand bones (HP:0009699)1.72391803
104Low anterior hairline (HP:0000294)1.71111519
105Hyporeflexia of lower limbs (HP:0002600)1.71070274
106Abnormality of the parietal bone (HP:0002696)1.71007979
107Germ cell neoplasia (HP:0100728)1.70900308
108Increased number of teeth (HP:0011069)1.70822462
109Deviation of the thumb (HP:0009603)1.70772053
110Portal hypertension (HP:0001409)1.70593058
111Tubulointerstitial nephritis (HP:0001970)1.70380434
112Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.70314944
113Abnormality of the columella (HP:0009929)1.70273635
114Chin dimple (HP:0010751)1.68505316
115Pulmonic stenosis (HP:0001642)1.67412790
116Abnormality of the frontal sinuses (HP:0002687)1.67363108
117Septate vagina (HP:0001153)1.66986267
118Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.66844836
119Smooth philtrum (HP:0000319)1.66728618
120Obsessive-compulsive behavior (HP:0000722)1.66077417
121Delayed closure of the anterior fontanelle (HP:0001476)1.65252015
122Supernumerary bones of the axial skeleton (HP:0009144)1.65072306
123Milia (HP:0001056)1.63989435
124Transitional cell carcinoma of the bladder (HP:0006740)1.63525136
125Proximal placement of thumb (HP:0009623)1.62641970
126Biliary tract neoplasm (HP:0100574)1.62059503
127Neoplasm of the oral cavity (HP:0100649)1.61802555
128Wide nose (HP:0000445)1.61360245
129Bladder neoplasm (HP:0009725)1.61154766
130Bladder carcinoma (HP:0002862)1.61154766
131Chromsome breakage (HP:0040012)1.61088607
132Aortic dissection (HP:0002647)1.60999975
133T lymphocytopenia (HP:0005403)1.60916666
134Abnormality of the hepatic vasculature (HP:0006707)1.60292911
135Abnormal auditory evoked potentials (HP:0006958)1.60168728
136Hypoplasia of the iris (HP:0007676)1.60055538
137Difficulty running (HP:0009046)1.59962474
138Aneurysm (HP:0002617)1.59796727
139Thick nail (HP:0001805)1.59017486
140Sparse lateral eyebrow (HP:0005338)1.58986889
141Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.58803855
142Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.58481184
143Heterotopia (HP:0002282)1.58153104
144Abnormality of the distal phalanx of the thumb (HP:0009617)1.57986726
145Cardiovascular calcification (HP:0011915)1.57573367
146Labial hypoplasia (HP:0000066)1.56724392
147Short clavicles (HP:0000894)1.56694417
148Thickened calvaria (HP:0002684)1.56419352
149Thick eyebrow (HP:0000574)1.56365045
150Abnormality of homocysteine metabolism (HP:0010919)1.55778083
151Homocystinuria (HP:0002156)1.55778083
152Striae distensae (HP:0001065)1.55614342
153Prominent nose (HP:0000448)1.54865510
154Bell-shaped thorax (HP:0001591)1.54357360
155Cutaneous finger syndactyly (HP:0010554)1.52954893
156Truncal obesity (HP:0001956)1.50119273
157Bifid scrotum (HP:0000048)1.49965970
158Ankle contracture (HP:0006466)1.49721576
159Exostoses (HP:0100777)1.49495059
160Stomach cancer (HP:0012126)1.48674027
161Decreased lacrimation (HP:0000633)1.48023512
162Anophthalmia (HP:0000528)1.47914873
163Distal lower limb amyotrophy (HP:0008944)1.47492651

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT34.50477028
2LATS14.28431611
3CDK123.84423435
4NUAK13.05479495
5CAMK1D2.84986608
6SCYL22.65820718
7BRD42.64178978
8INSRR2.60250850
9CAMK1G2.53020702
10FGFR22.52498410
11SIK12.40454232
12FRK2.26244803
13STK32.19333816
14EPHA31.94212403
15SIK31.93138267
16BRSK21.93098355
17PIK3CG1.78184199
18ZAK1.59534014
19DMPK1.57112334
20CDK61.55977989
21PDGFRB1.54210263
22MET1.50852702
23BMPR21.50706984
24ERBB31.46503355
25EPHB21.45198899
26OBSCN1.43558316
27NLK1.41509912
28MAP3K61.38069744
29TGFBR21.37691950
30EIF2AK31.36484024
31FGFR31.34230009
32MST1R1.28961836
33ICK1.25772449
34NEK91.25115004
35ERBB21.23690384
36MTOR1.19310468
37EEF2K1.15086478
38TEC1.14696521
39PDGFRA1.14627878
40PKN21.14569333
41WNK11.12836738
42CHUK1.10841692
43PIK3CA1.10793627
44MAP3K141.10491757
45JAK11.04057120
46FGFR11.03815162
47EIF2AK21.02593378
48RET1.01097432
49BCR1.00362702
50FLT30.95592239
51SIK20.94062735
52DDR20.93520668
53ERBB40.92104471
54RAF10.89040399
55STK40.88597540
56STK390.88560263
57PRKAA20.88336194
58FER0.88211103
59ATR0.82281668
60ATM0.82114003
61STK38L0.81992485
62YES10.81855595
63PTK60.81694030
64MKNK20.80825454
65MARK20.80772569
66FGFR40.80199234
67TTN0.79932540
68EPHA20.79224349
69CDK90.78805520
70MELK0.76756043
71SGK4940.76646473
72SGK2230.76646473
73ACVR1B0.76568011
74MAP3K20.76147968
75MAPK110.75042162
76PAK20.74989025
77BLK0.74563612
78TRIB30.73609456
79RPS6KB20.71135266
80EPHB10.70654340
81MAP2K10.70596217
82RIPK40.69605054
83MKNK10.69090693
84IKBKE0.68314996
85MAP3K70.68173193
86CDC70.68053292
87PASK0.66437269
88MAP2K30.66086657
89ITK0.66011693
90BMPR1B0.65182712
91ZAP700.64993812
92TYK20.64086846
93CSF1R0.62767587
94JAK30.61651857
95MAP3K100.61649992
96PTK20.60942341
97SGK30.60726766
98INSR0.60665558
99IRAK40.60587902
100NEK60.59992714
101TRPM70.59322376
102CHEK20.58903868
103CSNK1D0.58613828
104MAPK100.58368999
105STK240.56394417
106PRKAA10.55887721
107IRAK10.55814430
108TTK0.55493301
109CHEK10.55412422
110RIPK10.54987414
111RPS6KB10.54244033
112JAK20.53600148
113MARK30.53552441
114SGK10.53461690
115STK380.53190131
116IKBKB0.53171264
117CSNK1A1L0.53165325
118IGF1R0.52670153
119KSR10.52553797
120BMX0.52180320
121EGFR0.50804297
122PRKCQ0.50422582
123TAOK30.49880397
124CDK30.49506573
125STK100.49410191
126MAPK10.48303751
127BTK0.48255220
128MAPK140.48157230
129CDK40.47862500
130PKN10.46764503
131PLK30.46550359
132PRKDC0.46229230
133SGK20.45961670
134HCK0.45725949
135PLK20.45458672
136PIM10.45403546
137CLK10.44791046
138CAMKK20.44253308
139ABL10.43812093
140PNCK0.43527586
141MAPK70.42884310
142LATS20.39767711
143TLK10.38832113
144PTK2B0.38499863
145MAP3K40.35201163
146GSK3A0.32608914
147CAMK40.29582688

Predicted pathways (KEGG)

RankGene SetZ-score
1Adherens junction_Homo sapiens_hsa045202.16663134
2MicroRNAs in cancer_Homo sapiens_hsa052061.91877449
3Lysine degradation_Homo sapiens_hsa003101.89347227
4ECM-receptor interaction_Homo sapiens_hsa045121.81283828
5Basal cell carcinoma_Homo sapiens_hsa052171.70857442
6Small cell lung cancer_Homo sapiens_hsa052221.66591905
7NF-kappa B signaling pathway_Homo sapiens_hsa040641.61495814
8Proteoglycans in cancer_Homo sapiens_hsa052051.57580543
9Thyroid cancer_Homo sapiens_hsa052161.52639803
10TGF-beta signaling pathway_Homo sapiens_hsa043501.44524506
11Focal adhesion_Homo sapiens_hsa045101.43464549
12Prostate cancer_Homo sapiens_hsa052151.43034819
13Prolactin signaling pathway_Homo sapiens_hsa049171.42784016
14Transcriptional misregulation in cancer_Homo sapiens_hsa052021.37621349
15Circadian rhythm_Homo sapiens_hsa047101.36444995
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.35350201
17Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.31640340
18Acute myeloid leukemia_Homo sapiens_hsa052211.30232643
19Chronic myeloid leukemia_Homo sapiens_hsa052201.29757952
20Type II diabetes mellitus_Homo sapiens_hsa049301.28233727
21Fatty acid biosynthesis_Homo sapiens_hsa000611.26768793
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.24320204
23Hippo signaling pathway_Homo sapiens_hsa043901.23789137
24Hedgehog signaling pathway_Homo sapiens_hsa043401.20020792
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.19769178
26Wnt signaling pathway_Homo sapiens_hsa043101.15846794
27Dorso-ventral axis formation_Homo sapiens_hsa043201.15101799
28Axon guidance_Homo sapiens_hsa043601.14680834
29Viral myocarditis_Homo sapiens_hsa054161.14336195
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13341740
31Malaria_Homo sapiens_hsa051441.12973000
32Non-homologous end-joining_Homo sapiens_hsa034501.12952676
33Toxoplasmosis_Homo sapiens_hsa051451.12080316
34Osteoclast differentiation_Homo sapiens_hsa043801.08405639
35TNF signaling pathway_Homo sapiens_hsa046681.07487190
36Amoebiasis_Homo sapiens_hsa051461.07417880
37Pathways in cancer_Homo sapiens_hsa052001.06461580
38Regulation of actin cytoskeleton_Homo sapiens_hsa048101.03971285
39Pancreatic cancer_Homo sapiens_hsa052121.03710881
40Leishmaniasis_Homo sapiens_hsa051401.03236636
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.03033011
42Melanoma_Homo sapiens_hsa052181.02421501
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00239975
44Alcoholism_Homo sapiens_hsa050340.99886505
45Neurotrophin signaling pathway_Homo sapiens_hsa047220.99448911
46Leukocyte transendothelial migration_Homo sapiens_hsa046700.99347001
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97957556
48Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.97308136
49Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97284772
50PI3K-Akt signaling pathway_Homo sapiens_hsa041510.94914059
51Notch signaling pathway_Homo sapiens_hsa043300.94243160
52Systemic lupus erythematosus_Homo sapiens_hsa053220.93064870
53Adipocytokine signaling pathway_Homo sapiens_hsa049200.91103748
54Measles_Homo sapiens_hsa051620.90822281
55Dilated cardiomyopathy_Homo sapiens_hsa054140.90644096
56African trypanosomiasis_Homo sapiens_hsa051430.90310654
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89818180
58mTOR signaling pathway_Homo sapiens_hsa041500.89712844
59FoxO signaling pathway_Homo sapiens_hsa040680.89127665
60HTLV-I infection_Homo sapiens_hsa051660.88959512
61Platelet activation_Homo sapiens_hsa046110.87844621
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.87779615
63Hematopoietic cell lineage_Homo sapiens_hsa046400.87416844
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87233091
65p53 signaling pathway_Homo sapiens_hsa041150.87012151
66Rap1 signaling pathway_Homo sapiens_hsa040150.86921216
67Fanconi anemia pathway_Homo sapiens_hsa034600.86806216
68B cell receptor signaling pathway_Homo sapiens_hsa046620.86167357
69Hepatitis B_Homo sapiens_hsa051610.86096807
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84887798
71VEGF signaling pathway_Homo sapiens_hsa043700.84824523
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83384951
73ErbB signaling pathway_Homo sapiens_hsa040120.81991052
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81773823
75Herpes simplex infection_Homo sapiens_hsa051680.80871724
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80593344
77Viral carcinogenesis_Homo sapiens_hsa052030.80460488
78Glioma_Homo sapiens_hsa052140.80010914
79Estrogen signaling pathway_Homo sapiens_hsa049150.79310017
80Renal cell carcinoma_Homo sapiens_hsa052110.78763146
81Renin-angiotensin system_Homo sapiens_hsa046140.78578262
82Insulin signaling pathway_Homo sapiens_hsa049100.78491647
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77459606
84GnRH signaling pathway_Homo sapiens_hsa049120.77459504
85Protein digestion and absorption_Homo sapiens_hsa049740.76415474
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76371918
87Insulin resistance_Homo sapiens_hsa049310.74540512
88Renin secretion_Homo sapiens_hsa049240.70618303
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70454440
90Choline metabolism in cancer_Homo sapiens_hsa052310.68951956
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.68735569
92Inositol phosphate metabolism_Homo sapiens_hsa005620.68731561
93Influenza A_Homo sapiens_hsa051640.68230802
94T cell receptor signaling pathway_Homo sapiens_hsa046600.67616494
95MAPK signaling pathway_Homo sapiens_hsa040100.67221549
96Endometrial cancer_Homo sapiens_hsa052130.66740680
97Colorectal cancer_Homo sapiens_hsa052100.66659015
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66029116
99Ras signaling pathway_Homo sapiens_hsa040140.65238917
100Melanogenesis_Homo sapiens_hsa049160.65107361
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.64982396
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64824736
103AMPK signaling pathway_Homo sapiens_hsa041520.64800722
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64485854
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63619703
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62305278
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62252965
108Cell cycle_Homo sapiens_hsa041100.61871788
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60971031
110Long-term depression_Homo sapiens_hsa047300.60656353
111Apoptosis_Homo sapiens_hsa042100.60538729
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59412987
113Glucagon signaling pathway_Homo sapiens_hsa049220.59269229
114Tight junction_Homo sapiens_hsa045300.59050032
115cAMP signaling pathway_Homo sapiens_hsa040240.58253665
116Chemokine signaling pathway_Homo sapiens_hsa040620.58150384
117Non-small cell lung cancer_Homo sapiens_hsa052230.57056609
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55940292
119Staphylococcus aureus infection_Homo sapiens_hsa051500.55688220
120Hepatitis C_Homo sapiens_hsa051600.55024208
121Bladder cancer_Homo sapiens_hsa052190.54170335
122HIF-1 signaling pathway_Homo sapiens_hsa040660.53753508
123Nitrogen metabolism_Homo sapiens_hsa009100.53652803
124ABC transporters_Homo sapiens_hsa020100.53188997
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.52970686
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52718004
127Gap junction_Homo sapiens_hsa045400.51820337

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