ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protoporphyrinogen IX biosynthetic process (GO:0006782)	5.02280068
2	centriole replication (GO:0007099)	4.83800438
3	behavioral response to nicotine (GO:0035095)	4.43309972
4	nonmotile primary cilium assembly (GO:0035058)	4.19450338
5	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	4.00861823
6	N-acetylneuraminate metabolic process (GO:0006054)	3.99761507
7	pyrimidine nucleobase catabolic process (GO:0006208)	3.98512905
8	presynaptic membrane assembly (GO:0097105)	3.88718051
9	intraciliary transport (GO:0042073)	3.88542209
10	protoporphyrinogen IX metabolic process (GO:0046501)	3.74265311
11	N-acetylglucosamine metabolic process (GO:0006044)	3.62311379
12	thalamus development (GO:0021794)	3.58036591
13	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.53387181
14	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.53387181
15	epithelial cilium movement (GO:0003351)	3.41153234
16	protein localization to cilium (GO:0061512)	3.40302512
17	base-excision repair, AP site formation (GO:0006285)	3.38203600
18	nucleobase catabolic process (GO:0046113)	3.34150862
19	postsynaptic membrane organization (GO:0001941)	3.31665885
20	protein deneddylation (GO:0000338)	3.31293430
21	dendritic spine morphogenesis (GO:0060997)	3.30496046
22	regulation of cilium movement (GO:0003352)	3.28195510
23	presynaptic membrane organization (GO:0097090)	3.22549743
24	positive regulation of mitochondrial fission (GO:0090141)	3.21968236
25	regulation of synapse structural plasticity (GO:0051823)	3.21501013
26	gamma-aminobutyric acid transport (GO:0015812)	3.15411082
27	prostate gland growth (GO:0060736)	3.14425707
28	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.13768896
29	centriole assembly (GO:0098534)	3.07623425
30	DNA double-strand break processing (GO:0000729)	3.02418854
31	short-term memory (GO:0007614)	2.99583306
32	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.84127830
33	response to misfolded protein (GO:0051788)	2.84095249
34	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.83339198
35	neuron cell-cell adhesion (GO:0007158)	2.82905216
36	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.81934433
37	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.80694260
38	olfactory bulb development (GO:0021772)	2.80212117
39	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	2.76402529
40	regulation of MHC class II biosynthetic process (GO:0045346)	2.75436243
41	pyrimidine dimer repair (GO:0006290)	2.73960890
42	peptidyl-histidine modification (GO:0018202)	2.71615429
43	cilium organization (GO:0044782)	2.70790225
44	response to pheromone (GO:0019236)	2.69801513
45	cilium assembly (GO:0042384)	2.68802982
46	regulation of hexokinase activity (GO:1903299)	2.68779175
47	regulation of glucokinase activity (GO:0033131)	2.68779175
48	retinal ganglion cell axon guidance (GO:0031290)	2.67017517
49	positive regulation of histone deacetylation (GO:0031065)	2.66875148
50	cilium movement (GO:0003341)	2.62711425
51	regulation of helicase activity (GO:0051095)	2.61794761
52	vocalization behavior (GO:0071625)	2.61298988
53	synapse assembly (GO:0007416)	2.61003834
54	regulation of oligodendrocyte differentiation (GO:0048713)	2.59332765
55	neuronal action potential propagation (GO:0019227)	2.59235122
56	limb bud formation (GO:0060174)	2.58013364
57	transmission of nerve impulse (GO:0019226)	2.57195031
58	synaptic transmission, cholinergic (GO:0007271)	2.56806633
59	cilium morphogenesis (GO:0060271)	2.55002475
60	regulation of feeding behavior (GO:0060259)	2.52351365
61	glutamate receptor signaling pathway (GO:0007215)	2.51473601
62	regulation of neurotransmitter uptake (GO:0051580)	2.49860379
63	insulin-like growth factor receptor signaling pathway (GO:0048009)	2.48647400
64	DNA integration (GO:0015074)	2.48523779
65	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.47957576
66	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	2.47382332
67	regulation of glycolytic process (GO:0006110)	2.47347870
68	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.44871819
69	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.44871819
70	isotype switching (GO:0045190)	2.44871819
71	regulation of cofactor metabolic process (GO:0051193)	2.44830060
72	regulation of coenzyme metabolic process (GO:0051196)	2.44830060
73	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.44737365
74	cullin deneddylation (GO:0010388)	2.43788521
75	response to folic acid (GO:0051593)	2.43023810
76	axonal fasciculation (GO:0007413)	2.36987093
77	cerebral cortex radially oriented cell migration (GO:0021799)	2.36687024
78	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.36452149
79	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.36452149
80	preassembly of GPI anchor in ER membrane (GO:0016254)	2.36251034
81	water-soluble vitamin biosynthetic process (GO:0042364)	2.35354229
82	ventricular system development (GO:0021591)	2.34386754
83	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.33011603
84	retinal cone cell development (GO:0046549)	2.32758981
85	purine deoxyribonucleotide catabolic process (GO:0009155)	2.30641279
86	regulation of development, heterochronic (GO:0040034)	2.29867597
87	cytokinetic process (GO:0032506)	2.29723402
88	smoothened signaling pathway (GO:0007224)	2.29607230
89	mannosylation (GO:0097502)	2.29401215
90	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.29041007
91	auditory behavior (GO:0031223)	2.25882566
92	establishment of melanosome localization (GO:0032401)	2.24377873
93	positive regulation of dendritic spine development (GO:0060999)	2.24181172
94	glucosamine-containing compound metabolic process (GO:1901071)	2.22104599
95	mechanosensory behavior (GO:0007638)	2.20798257
96	neurotransmitter-gated ion channel clustering (GO:0072578)	2.20468461
97	positive regulation of synapse assembly (GO:0051965)	2.20141273
98	cornea development in camera-type eye (GO:0061303)	2.19764656
99	L-fucose metabolic process (GO:0042354)	2.19194378
100	L-fucose catabolic process (GO:0042355)	2.19194378

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	4.12131737
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.73021538
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.20997943
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.19303578
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.99319261
6	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.85728289
7	VDR_22108803_ChIP-Seq_LS180_Human	2.74523483
8	EZH2_22144423_ChIP-Seq_EOC_Human	2.73658099
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.65555018
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.60345477
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.60266822
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.57632364
13	FUS_26573619_Chip-Seq_HEK293_Human	2.36510133
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.25738204
15	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.18279928
16	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.17137919
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.06266716
18	IRF1_19129219_ChIP-ChIP_H3396_Human	2.04908324
19	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.01616411
20	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.98082306
21	EWS_26573619_Chip-Seq_HEK293_Human	1.96445766
22	TAF15_26573619_Chip-Seq_HEK293_Human	1.94676919
23	P300_19829295_ChIP-Seq_ESCs_Human	1.89936376
24	ELK1_19687146_ChIP-ChIP_HELA_Human	1.87634104
25	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.87452739
26	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.62946914
27	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.60871821
28	ER_23166858_ChIP-Seq_MCF-7_Human	1.59468030
29	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.57191118
30	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.55339268
31	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.49978441
32	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.49828199
33	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.47926070
34	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.47268532
35	RNF2_27304074_Chip-Seq_NSC_Mouse	1.46526259
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.45195431
37	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.45157344
38	SMAD4_21799915_ChIP-Seq_A2780_Human	1.44129716
39	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.42213119
40	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.38934575
41	MYC_18940864_ChIP-ChIP_HL60_Human	1.34659568
42	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.34242424
43	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.33817609
44	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.31661435
45	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.29624005
46	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.28292119
47	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.26576773
48	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.25872512
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.25872512
50	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.25779906
51	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.25659434
52	STAT3_23295773_ChIP-Seq_U87_Human	1.24589891
53	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.22650140
54	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.22550063
55	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.22405726
56	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.18944742
57	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.18600783
58	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.17914805
59	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.17597840
60	BCAT_22108803_ChIP-Seq_LS180_Human	1.16583223
61	REST_21632747_ChIP-Seq_MESCs_Mouse	1.16178835
62	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.15340232
63	AR_25329375_ChIP-Seq_VCAP_Human	1.14505909
64	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.14363378
65	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.12152540
66	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.11653683
67	TP53_22573176_ChIP-Seq_HFKS_Human	1.11598335
68	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.09645270
69	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.09186603
70	TCF4_23295773_ChIP-Seq_U87_Human	1.08980085
71	SOX2_19829295_ChIP-Seq_ESCs_Human	1.08752556
72	NANOG_19829295_ChIP-Seq_ESCs_Human	1.08752556
73	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.07877861
74	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.07823700
75	VDR_23849224_ChIP-Seq_CD4+_Human	1.07770026
76	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.05910560
77	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.05871339
78	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.04593512
79	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.04241361
80	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.03938063
81	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.03228805
82	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.03018577
83	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.02610982
84	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.01876342
85	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.97214362
86	P53_22387025_ChIP-Seq_ESCs_Mouse	0.96912368
87	JUN_21703547_ChIP-Seq_K562_Human	0.96811764
88	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.96537499
89	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96537499
90	SOX9_26525672_Chip-Seq_HEART_Mouse	0.96526599
91	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.95808851
92	AR_21572438_ChIP-Seq_LNCaP_Human	0.95592484
93	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.95190513
94	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.95180760
95	RUNX2_22187159_ChIP-Seq_PCA_Human	0.94710726
96	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.93488601
97	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.92521292
98	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.92444595
99	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.91688398
100	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.90852545

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005083_abnormal_biliary_tract	3.88253190
2	MP0001529_abnormal_vocalization	3.01910726
3	MP0001984_abnormal_olfaction	2.58126854
4	MP0008058_abnormal_DNA_repair	2.35672761
5	MP0004043_abnormal_pH_regulation	2.27266441
6	MP0003122_maternal_imprinting	2.12700422
7	MP0003121_genomic_imprinting	2.02319752
8	MP0008789_abnormal_olfactory_epithelium	1.99148067
9	MP0005394_taste/olfaction_phenotype	1.95948576
10	MP0005499_abnormal_olfactory_system	1.95948576
11	MP0002653_abnormal_ependyma_morphology	1.92670203
12	MP0003880_abnormal_central_pattern	1.90003520
13	MP0008961_abnormal_basal_metabolism	1.83187735
14	MP0002102_abnormal_ear_morphology	1.81201237
15	MP0004885_abnormal_endolymph	1.80700482
16	MP0000569_abnormal_digit_pigmentation	1.78627406
17	MP0009745_abnormal_behavioral_response	1.74439302
18	MP0000778_abnormal_nervous_system	1.73380747
19	MP0004142_abnormal_muscle_tone	1.72394356
20	MP0006276_abnormal_autonomic_nervous	1.68781916
21	MP0006292_abnormal_olfactory_placode	1.68718728
22	MP0008877_abnormal_DNA_methylation	1.67016927
23	MP0005551_abnormal_eye_electrophysiolog	1.66845494
24	MP0002638_abnormal_pupillary_reflex	1.66306962
25	MP0009046_muscle_twitch	1.66003643
26	MP0002822_catalepsy	1.61732111
27	MP0006072_abnormal_retinal_apoptosis	1.59557102
28	MP0002272_abnormal_nervous_system	1.57018866
29	MP0002234_abnormal_pharynx_morphology	1.54072320
30	MP0003136_yellow_coat_color	1.50124967
31	MP0003123_paternal_imprinting	1.48292351
32	MP0002736_abnormal_nociception_after	1.47374667
33	MP0004270_analgesia	1.46774146
34	MP0004133_heterotaxia	1.44665132
35	MP0005253_abnormal_eye_physiology	1.42680438
36	MP0001968_abnormal_touch/_nociception	1.40357363
37	MP0002938_white_spotting	1.38834662
38	MP0000955_abnormal_spinal_cord	1.38246821
39	MP0003787_abnormal_imprinting	1.36936417
40	MP0002572_abnormal_emotion/affect_behav	1.36701817
41	MP0002063_abnormal_learning/memory/cond	1.32915926
42	MP0004859_abnormal_synaptic_plasticity	1.31556383
43	MP0002909_abnormal_adrenal_gland	1.31240452
44	MP0003635_abnormal_synaptic_transmissio	1.30954725
45	MP0002184_abnormal_innervation	1.27998822
46	MP0001486_abnormal_startle_reflex	1.24437346
47	MP0002837_dystrophic_cardiac_calcinosis	1.21688064
48	MP0005365_abnormal_bile_salt	1.20618701
49	MP0002734_abnormal_mechanical_nocicepti	1.20360948
50	MP0005645_abnormal_hypothalamus_physiol	1.19945142
51	MP0002751_abnormal_autonomic_nervous	1.16167713
52	MP0002557_abnormal_social/conspecific_i	1.15810553
53	MP0005367_renal/urinary_system_phenotyp	1.15463123
54	MP0000516_abnormal_urinary_system	1.15463123
55	MP0001502_abnormal_circadian_rhythm	1.15018080
56	MP0005171_absent_coat_pigmentation	1.14347992
57	MP0008872_abnormal_physiological_respon	1.12876256
58	MP0003119_abnormal_digestive_system	1.11971525
59	MP0000049_abnormal_middle_ear	1.11721355
60	MP0001177_atelectasis	1.11602136
61	MP0001970_abnormal_pain_threshold	1.11552322
62	MP0002064_seizures	1.09425650
63	MP0002882_abnormal_neuron_morphology	1.06528621
64	MP0001324_abnormal_eye_pigmentation	1.04291353
65	MP0002735_abnormal_chemical_nociception	1.04222103
66	MP0003011_delayed_dark_adaptation	1.04161216
67	MP0001986_abnormal_taste_sensitivity	1.03956486
68	MP0005670_abnormal_white_adipose	1.03655531
69	MP0002752_abnormal_somatic_nervous	1.02990601
70	MP0005085_abnormal_gallbladder_physiolo	1.01624067
71	MP0005248_abnormal_Harderian_gland	1.01158948
72	MP0003937_abnormal_limbs/digits/tail_de	1.00957351
73	MP0001293_anophthalmia	1.00890999
74	MP0000631_abnormal_neuroendocrine_gland	1.00851619
75	MP0003195_calcinosis	1.00326255
76	MP0002233_abnormal_nose_morphology	1.00210243
77	MP0003252_abnormal_bile_duct	0.99305618
78	MP0002067_abnormal_sensory_capabilities	0.98563710
79	MP0003221_abnormal_cardiomyocyte_apopto	0.97956032
80	MP0004742_abnormal_vestibular_system	0.96569875
81	MP0000026_abnormal_inner_ear	0.96564236
82	MP0003567_abnormal_fetal_cardiomyocyte	0.94585488
83	MP0000372_irregular_coat_pigmentation	0.93286794
84	MP0003938_abnormal_ear_development	0.92070796
85	MP0005084_abnormal_gallbladder_morpholo	0.91568495
86	MP0008995_early_reproductive_senescence	0.90786457
87	MP0000427_abnormal_hair_cycle	0.89971662
88	MP0004924_abnormal_behavior	0.89440402
89	MP0005386_behavior/neurological_phenoty	0.89440402
90	MP0002733_abnormal_thermal_nociception	0.88703626
91	MP0005187_abnormal_penis_morphology	0.87985384
92	MP0004811_abnormal_neuron_physiology	0.87072313
93	MP0003786_premature_aging	0.85898383
94	MP0008057_abnormal_DNA_replication	0.85226707
95	MP0005195_abnormal_posterior_eye	0.84590034
96	MP0002090_abnormal_vision	0.83607554
97	MP0002152_abnormal_brain_morphology	0.83224756
98	MP0003861_abnormal_nervous_system	0.81732725
99	MP0000647_abnormal_sebaceous_gland	0.79256747
100	MP0005423_abnormal_somatic_nervous	0.78567953

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Medial flaring of the eyebrow (HP:0010747)	3.96592616
2	Gait imbalance (HP:0002141)	3.82528024
3	Congenital primary aphakia (HP:0007707)	3.68181842
4	Nephrogenic diabetes insipidus (HP:0009806)	3.34084559
5	Genital tract atresia (HP:0001827)	3.18458366
6	Vaginal atresia (HP:0000148)	3.17050502
7	Hyperglycinemia (HP:0002154)	3.10634824
8	Tubulointerstitial nephritis (HP:0001970)	3.08430466
9	Drooling (HP:0002307)	3.04362769
10	Hepatoblastoma (HP:0002884)	2.88111974
11	True hermaphroditism (HP:0010459)	2.85167423
12	Nephronophthisis (HP:0000090)	2.78905316
13	Lissencephaly (HP:0001339)	2.71709598
14	Excessive salivation (HP:0003781)	2.70405353
15	Lipid accumulation in hepatocytes (HP:0006561)	2.66021294
16	Poor coordination (HP:0002370)	2.63451171
17	Pancreatic fibrosis (HP:0100732)	2.57891884
18	Increased hepatocellular lipid droplets (HP:0006565)	2.56251220
19	Pancreatic cysts (HP:0001737)	2.52956378
20	Abnormality of the labia minora (HP:0012880)	2.50950357
21	Abnormality of the renal medulla (HP:0100957)	2.50881166
22	Postaxial hand polydactyly (HP:0001162)	2.50732186
23	Broad foot (HP:0001769)	2.49587668
24	Abnormality of the metopic suture (HP:0005556)	2.45406976
25	Methylmalonic acidemia (HP:0002912)	2.36343747
26	Postaxial foot polydactyly (HP:0001830)	2.34784286
27	Retinal dysplasia (HP:0007973)	2.33577120
28	Pachygyria (HP:0001302)	2.30083090
29	Ketoacidosis (HP:0001993)	2.27980460
30	Type II lissencephaly (HP:0007260)	2.27409453
31	Broad-based gait (HP:0002136)	2.27351742
32	Sclerocornea (HP:0000647)	2.22108462
33	Hypoplastic pelvis (HP:0008839)	2.22042072
34	Neoplasm of the adrenal cortex (HP:0100641)	2.20470555
35	Rib fusion (HP:0000902)	2.18216022
36	Absent speech (HP:0001344)	2.17176558
37	Aplasia/Hypoplasia of the lens (HP:0008063)	2.16182783
38	Decreased testicular size (HP:0008734)	2.12548697
39	Failure to thrive in infancy (HP:0001531)	2.11307929
40	Specific learning disability (HP:0001328)	2.11007827
41	Abnormality of the renal cortex (HP:0011035)	2.10419785
42	Progressive cerebellar ataxia (HP:0002073)	2.09647412
43	Colon cancer (HP:0003003)	2.09255324
44	Progressive inability to walk (HP:0002505)	2.08894146
45	Cortical dysplasia (HP:0002539)	2.06036797
46	Hemiparesis (HP:0001269)	2.04727363
47	Septo-optic dysplasia (HP:0100842)	2.04640227
48	Renal Fanconi syndrome (HP:0001994)	2.03382939
49	Long clavicles (HP:0000890)	2.03217861
50	Increased serum pyruvate (HP:0003542)	2.02933471
51	Prominent metopic ridge (HP:0005487)	2.01559505
52	Limb dystonia (HP:0002451)	2.00786836
53	Short foot (HP:0001773)	1.97378850
54	Polyphagia (HP:0002591)	1.97159971
55	Partial agenesis of the corpus callosum (HP:0001338)	1.96921722
56	Occipital encephalocele (HP:0002085)	1.96674865
57	Optic nerve hypoplasia (HP:0000609)	1.96473548
58	Renal cortical cysts (HP:0000803)	1.95898171
59	Hyperventilation (HP:0002883)	1.95697378
60	Tubulointerstitial abnormality (HP:0001969)	1.95453143
61	Abnormality of glycolysis (HP:0004366)	1.95165743
62	Intestinal atresia (HP:0011100)	1.94996333
63	Molar tooth sign on MRI (HP:0002419)	1.93621088
64	Abnormality of midbrain morphology (HP:0002418)	1.93621088
65	Hypoplasia of the brainstem (HP:0002365)	1.92194950
66	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.92194950
67	Meckel diverticulum (HP:0002245)	1.91694009
68	Hypsarrhythmia (HP:0002521)	1.91565438
69	Acute encephalopathy (HP:0006846)	1.89031721
70	Epidermoid cyst (HP:0200040)	1.85513433
71	Progressive microcephaly (HP:0000253)	1.83983961
72	Abnormality of the ileum (HP:0001549)	1.82343611
73	EEG with generalized epileptiform discharges (HP:0011198)	1.80497623
74	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.80065315
75	Astigmatism (HP:0000483)	1.80061061
76	Febrile seizures (HP:0002373)	1.79219021
77	Epileptiform EEG discharges (HP:0011182)	1.78489511
78	Acute necrotizing encephalopathy (HP:0006965)	1.77204186
79	Inability to walk (HP:0002540)	1.76479814
80	Poor suck (HP:0002033)	1.75743281
81	Anencephaly (HP:0002323)	1.73890107
82	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.73729372
83	Preaxial hand polydactyly (HP:0001177)	1.73683469
84	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.73561401
85	Micropenis (HP:0000054)	1.72152940
86	Focal motor seizures (HP:0011153)	1.71564064
87	Delayed CNS myelination (HP:0002188)	1.70484709
88	Congenital hepatic fibrosis (HP:0002612)	1.70236954
89	Aganglionic megacolon (HP:0002251)	1.68223792
90	Delayed gross motor development (HP:0002194)	1.66148700
91	Methylmalonic aciduria (HP:0012120)	1.66016900
92	Anterior segment dysgenesis (HP:0007700)	1.65213018
93	Neoplasm of the adrenal gland (HP:0100631)	1.64242084
94	Mitochondrial inheritance (HP:0001427)	1.64185686
95	Aplasia/hypoplasia of the uterus (HP:0008684)	1.63083803
96	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.61762287
97	Spastic tetraplegia (HP:0002510)	1.60477467
98	Multicystic kidney dysplasia (HP:0000003)	1.60140811
99	Retinal atrophy (HP:0001105)	1.59898248
100	Polymicrogyria (HP:0002126)	1.59890166

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CCNB1	5.03046940
2	NEK2	3.77741659
3	WNK3	3.20461065
4	CAMKK2	2.98515055
5	MAP3K4	2.90443994
6	BCR	2.88600649
7	MAP2K7	2.57185276
8	MARK1	2.51663383
9	CASK	2.33347494
10	FRK	2.11142008
11	TRIM28	2.09619110
12	WNK4	2.06529850
13	MAP4K2	1.99507068
14	VRK2	1.94951164
15	SRPK1	1.94334288
16	CSNK1G3	1.79789532
17	MAPK13	1.73318149
18	CSNK1G1	1.69951837
19	CSNK1G2	1.65095220
20	CSNK1A1L	1.60115071
21	DYRK2	1.58655878
22	CAMK1D	1.54499131
23	TAF1	1.54333602
24	ERBB3	1.53590243
25	NUAK1	1.49387427
26	VRK1	1.37758311
27	PLK2	1.34087176
28	WEE1	1.31601441
29	PAK3	1.29028706
30	EPHA3	1.27497749
31	PLK3	1.24786026
32	RPS6KA4	1.15463462
33	EPHA4	1.07615814
34	MKNK1	1.04959852
35	ADRBK2	1.04948314
36	PBK	1.04083307
37	TSSK6	1.03302272
38	BCKDK	1.03127246
39	STK16	1.02915454
40	CAMK1G	1.02275959
41	DYRK3	1.00514547
42	PNCK	1.00351930
43	MKNK2	0.95572860
44	PRKCG	0.95393461
45	PRKCE	0.94745969
46	INSRR	0.93296010
47	CAMK1	0.89271441
48	LIMK1	0.87550396
49	ZAK	0.87183587
50	NTRK2	0.84621792
51	PINK1	0.81537201
52	NTRK3	0.80799454
53	GRK1	0.80731120
54	CAMK4	0.80265070
55	MAP2K4	0.79027963
56	BMPR1B	0.78428667
57	PRKD3	0.78054309
58	BRSK2	0.75108878
59	MAP3K7	0.72193195
60	MAPK15	0.70227247
61	STK39	0.68857217
62	CAMKK1	0.64194363
63	DYRK1A	0.62746881
64	FGFR2	0.60916091
65	MAPKAPK5	0.59928638
66	NEK1	0.59840103
67	CAMK2B	0.57827988
68	CHUK	0.55086003
69	SGK223	0.52273521
70	SGK494	0.52273521
71	GRK7	0.52149515
72	CDC7	0.51665888
73	PIK3CA	0.51287015
74	EIF2AK1	0.51251914
75	TNIK	0.50121016
76	PLK4	0.49635215
77	CSNK1A1	0.49389048
78	UHMK1	0.49093128
79	PLK1	0.48168355
80	EIF2AK2	0.46633968
81	CSNK1D	0.46549231
82	MINK1	0.45947092
83	EIF2AK3	0.45853827
84	BUB1	0.45458471
85	CDK14	0.44815286
86	RPS6KA5	0.43997039
87	CAMK2A	0.43669266
88	STK38L	0.42732097
89	GRK5	0.42440723
90	EPHB2	0.42102367
91	KSR1	0.41175439
92	TESK1	0.40685922
93	AKT3	0.39845386
94	CAMK2D	0.39832997
95	SGK2	0.39146167
96	PRKAA1	0.38542407
97	PKN1	0.37547775
98	OBSCN	0.36649766
99	CDK18	0.36248660
100	PASK	0.35471596

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	2.66400502
2	Protein export_Homo sapiens_hsa03060	2.39638588
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.39006843
4	Propanoate metabolism_Homo sapiens_hsa00640	2.34424213
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.04452986
6	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.03775403
7	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.03128412
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.94269213
9	Basal transcription factors_Homo sapiens_hsa03022	1.93129712
10	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.91246047
11	Butanoate metabolism_Homo sapiens_hsa00650	1.91146408
12	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.88777944
13	Fanconi anemia pathway_Homo sapiens_hsa03460	1.87814827
14	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.72246692
15	Steroid biosynthesis_Homo sapiens_hsa00100	1.68506726
16	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.66022137
17	Mismatch repair_Homo sapiens_hsa03430	1.61131708
18	Pyruvate metabolism_Homo sapiens_hsa00620	1.57603021
19	Fatty acid elongation_Homo sapiens_hsa00062	1.57200889
20	Parkinsons disease_Homo sapiens_hsa05012	1.56411154
21	Phototransduction_Homo sapiens_hsa04744	1.52605719
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.49810908
23	GABAergic synapse_Homo sapiens_hsa04727	1.45645898
24	Homologous recombination_Homo sapiens_hsa03440	1.37167812
25	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.34289238
26	Base excision repair_Homo sapiens_hsa03410	1.33042871
27	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.30445774
28	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.28887168
29	Selenocompound metabolism_Homo sapiens_hsa00450	1.28482815
30	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.27548153
31	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.27252177
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.25787569
33	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.21109659
34	Nucleotide excision repair_Homo sapiens_hsa03420	1.19173010
35	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.18066322
36	Non-homologous end-joining_Homo sapiens_hsa03450	1.16532542
37	Glutamatergic synapse_Homo sapiens_hsa04724	1.15769936
38	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.11867193
39	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.08336102
40	Circadian entrainment_Homo sapiens_hsa04713	1.07483607
41	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.03852893
42	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.03467821
43	Axon guidance_Homo sapiens_hsa04360	1.03414834
44	Morphine addiction_Homo sapiens_hsa05032	1.03280973
45	DNA replication_Homo sapiens_hsa03030	1.01790758
46	Huntingtons disease_Homo sapiens_hsa05016	1.00057385
47	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.99755793
48	Peroxisome_Homo sapiens_hsa04146	0.99068180
49	Collecting duct acid secretion_Homo sapiens_hsa04966	0.98142741
50	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.97254349
51	Taste transduction_Homo sapiens_hsa04742	0.92008458
52	Basal cell carcinoma_Homo sapiens_hsa05217	0.91591917
53	beta-Alanine metabolism_Homo sapiens_hsa00410	0.91552035
54	Cardiac muscle contraction_Homo sapiens_hsa04260	0.91515539
55	Glutathione metabolism_Homo sapiens_hsa00480	0.89722759
56	Ether lipid metabolism_Homo sapiens_hsa00565	0.88942579
57	Dopaminergic synapse_Homo sapiens_hsa04728	0.87945121
58	RNA polymerase_Homo sapiens_hsa03020	0.86285366
59	RNA degradation_Homo sapiens_hsa03018	0.85311422
60	Oocyte meiosis_Homo sapiens_hsa04114	0.82780498
61	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.82737682
62	Alzheimers disease_Homo sapiens_hsa05010	0.82135176
63	Vibrio cholerae infection_Homo sapiens_hsa05110	0.81884134
64	Regulation of autophagy_Homo sapiens_hsa04140	0.80157335
65	Folate biosynthesis_Homo sapiens_hsa00790	0.79486767
66	Fatty acid metabolism_Homo sapiens_hsa01212	0.79111657
67	Circadian rhythm_Homo sapiens_hsa04710	0.76750361
68	Renin-angiotensin system_Homo sapiens_hsa04614	0.75598796
69	Cocaine addiction_Homo sapiens_hsa05030	0.73225172
70	Linoleic acid metabolism_Homo sapiens_hsa00591	0.70098956
71	Metabolic pathways_Homo sapiens_hsa01100	0.69749889
72	Tryptophan metabolism_Homo sapiens_hsa00380	0.69657755
73	Caffeine metabolism_Homo sapiens_hsa00232	0.68326921
74	Alcoholism_Homo sapiens_hsa05034	0.65999352
75	Sulfur metabolism_Homo sapiens_hsa00920	0.65043478
76	Insulin secretion_Homo sapiens_hsa04911	0.63806312
77	Purine metabolism_Homo sapiens_hsa00230	0.62719574
78	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.61163225
79	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.59548074
80	RNA transport_Homo sapiens_hsa03013	0.59066291
81	Amphetamine addiction_Homo sapiens_hsa05031	0.57991813
82	Pyrimidine metabolism_Homo sapiens_hsa00240	0.57808027
83	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.57701965
84	Spliceosome_Homo sapiens_hsa03040	0.56228364
85	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.55370001
86	Fatty acid degradation_Homo sapiens_hsa00071	0.54561739
87	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.53669195
88	Carbon metabolism_Homo sapiens_hsa01200	0.52937937
89	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.52510452
90	Long-term depression_Homo sapiens_hsa04730	0.50380412
91	Lysine degradation_Homo sapiens_hsa00310	0.47684073
92	Arginine and proline metabolism_Homo sapiens_hsa00330	0.47490139
93	mRNA surveillance pathway_Homo sapiens_hsa03015	0.46393426
94	Hippo signaling pathway_Homo sapiens_hsa04390	0.46358569
95	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.46338098
96	Serotonergic synapse_Homo sapiens_hsa04726	0.46203721
97	Chemical carcinogenesis_Homo sapiens_hsa05204	0.45836943
98	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.45811083
99	Nitrogen metabolism_Homo sapiens_hsa00910	0.45802376
100	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.44806065

ZBED8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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