ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)	9.27512625
2	replicative senescence (GO:0090399)	8.23651383
3	eosinophil chemotaxis (GO:0048245)	7.97567027
4	cellular response to ethanol (GO:0071361)	7.79357634
5	protein prenylation (GO:0018342)	7.35955677
6	prenylation (GO:0097354)	7.35955677
7	regulation of lymphocyte chemotaxis (GO:1901623)	7.15945364
8	eosinophil migration (GO:0072677)	7.14081458
9	regulation of syncytium formation by plasma membrane fusion (GO:0060142)	6.89719093
10	hematopoietic stem cell proliferation (GO:0071425)	6.89263408
11	positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	6.69174280
12	activation of protein kinase A activity (GO:0034199)	6.08170428
13	cAMP biosynthetic process (GO:0006171)	5.96344466
14	post-anal tail morphogenesis (GO:0036342)	5.89819461
15	regulation of prostaglandin secretion (GO:0032306)	5.79896676
16	regulation of DNA damage checkpoint (GO:2000001)	5.61520848
17	sulfation (GO:0051923)	5.50475762
18	viral mRNA export from host cell nucleus (GO:0046784)	5.46832645
19	positive regulation of prostaglandin secretion (GO:0032308)	4.97934451
20	regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	4.87515509
21	osteoclast differentiation (GO:0030316)	4.67116248
22	monocyte chemotaxis (GO:0002548)	4.34641744
23	spleen development (GO:0048536)	4.33068669
24	cell adhesion mediated by integrin (GO:0033627)	4.32337554
25	membrane protein intracellular domain proteolysis (GO:0031293)	4.28881715
26	regulation of macrophage chemotaxis (GO:0010758)	4.24230169
27	wound healing, spreading of epidermal cells (GO:0035313)	4.22112131
28	negative regulation of catenin import into nucleus (GO:0035414)	4.07584493
29	regulation of endothelial cell differentiation (GO:0045601)	3.94662365
30	cellular extravasation (GO:0045123)	3.89554730
31	neutrophil mediated immunity (GO:0002446)	3.72629193
32	membrane protein ectodomain proteolysis (GO:0006509)	3.63471338
33	regulation of mononuclear cell migration (GO:0071675)	3.54942085
34	DNA replication-dependent nucleosome organization (GO:0034723)	3.54464862
35	DNA replication-dependent nucleosome assembly (GO:0006335)	3.54464862
36	positive regulation of lymphocyte migration (GO:2000403)	3.46416941
37	cellular response to exogenous dsRNA (GO:0071360)	3.28537626
38	segmentation (GO:0035282)	3.27158113
39	regulation of icosanoid secretion (GO:0032303)	3.26262063
40	positive regulation of RNA splicing (GO:0033120)	3.24912056
41	regulation of lymphocyte migration (GO:2000401)	3.22427408
42	response to lipoprotein particle (GO:0055094)	3.21926232
43	cellular response to interleukin-1 (GO:0071347)	3.20047018
44	somitogenesis (GO:0001756)	3.17562277
45	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	3.14606061
46	negative regulation of T-helper cell differentiation (GO:0045623)	3.14606061
47	positive regulation of fatty acid biosynthetic process (GO:0045723)	3.12682689
48	germinal center formation (GO:0002467)	3.06943808
49	tryptophan metabolic process (GO:0006568)	3.06739669
50	indolalkylamine catabolic process (GO:0046218)	3.06540843
51	tryptophan catabolic process (GO:0006569)	3.06540843
52	indole-containing compound catabolic process (GO:0042436)	3.06540843
53	positive regulation of icosanoid secretion (GO:0032305)	3.06224368
54	positive regulation of T cell chemotaxis (GO:0010820)	3.03954083
55	regulation of T cell chemotaxis (GO:0010819)	3.03954083
56	regulation of skeletal muscle contraction (GO:0014819)	3.03718480
57	interleukin-1-mediated signaling pathway (GO:0070498)	3.03528656
58	thymus development (GO:0048538)	3.00338761
59	lipopolysaccharide-mediated signaling pathway (GO:0031663)	2.99771870
60	negative regulation of systemic arterial blood pressure (GO:0003085)	2.95244482
61	cyclic purine nucleotide metabolic process (GO:0052652)	2.93477723
62	kynurenine metabolic process (GO:0070189)	2.91930443
63	negative regulation of leukocyte chemotaxis (GO:0002689)	2.91283284
64	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.91032929
65	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.91032929
66	cAMP metabolic process (GO:0046058)	2.90971993
67	cyclic nucleotide biosynthetic process (GO:0009190)	2.83526859
68	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.78133470
69	NADH dehydrogenase complex assembly (GO:0010257)	2.78133470
70	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.78133470
71	regulation of vitamin D biosynthetic process (GO:0060556)	2.76259967
72	regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)	2.74929334
73	innate immune response in mucosa (GO:0002227)	2.74761270
74	interferon-gamma secretion (GO:0072643)	2.71281330
75	righting reflex (GO:0060013)	2.69639499
76	T cell mediated immunity (GO:0002456)	2.67476732
77	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr	2.64859618
78	positive regulation of osteoclast differentiation (GO:0045672)	2.64097071
79	myeloid leukocyte mediated immunity (GO:0002444)	2.63074573
80	membrane protein proteolysis (GO:0033619)	2.62935733
81	wound healing, spreading of cells (GO:0044319)	2.62177171
82	positive regulation of fatty acid transport (GO:2000193)	2.61373683
83	vitamin A metabolic process (GO:0006776)	2.55660919
84	granulocyte chemotaxis (GO:0071621)	2.54625890
85	dendritic spine morphogenesis (GO:0060997)	2.54579985
86	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.53964199
87	detection of calcium ion (GO:0005513)	2.53924717
88	negative regulation of Rho protein signal transduction (GO:0035024)	2.53751034
89	regulation of inositol phosphate biosynthetic process (GO:0010919)	2.53744859
90	negative regulation of fibrinolysis (GO:0051918)	2.49443714
91	granulocyte migration (GO:0097530)	2.44499372
92	negative regulation of interleukin-17 production (GO:0032700)	2.43869995
93	protein localization to synapse (GO:0035418)	2.43487609
94	regulation of G2/M transition of mitotic cell cycle (GO:0010389)	2.40706585
95	positive regulation of leukocyte chemotaxis (GO:0002690)	2.40666344
96	lymphangiogenesis (GO:0001946)	2.40115404
97	cardiac muscle hypertrophy (GO:0003300)	2.39841566
98	cellular biogenic amine catabolic process (GO:0042402)	2.39571403
99	amine catabolic process (GO:0009310)	2.39571403
100	regulation of somitogenesis (GO:0014807)	14.4533859

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	5.11962007
2	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	4.83299066
3	SMAD_19615063_ChIP-ChIP_OVARY_Human	3.03102896
4	AR_21572438_ChIP-Seq_LNCaP_Human	2.48556106
5	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.31826155
6	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	2.28326611
7	GATA1_22025678_ChIP-Seq_K562_Human	2.24534699
8	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	2.23307878
9	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	13.2118763
10	STAT6_21828071_ChIP-Seq_BEAS2B_Human	10.0209429
11	TP53_16413492_ChIP-PET_HCT116_Human	1.84313147
12	IRF1_19129219_ChIP-ChIP_H3396_Human	1.73310747
13	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.69540997
14	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.63542575
15	VDR_22108803_ChIP-Seq_LS180_Human	1.47399072
16	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.38412297
17	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.37415146
18	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.36148229
19	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.35826569
20	VDR_24787735_ChIP-Seq_THP-1_Human	1.31317990
21	EZH2_22144423_ChIP-Seq_EOC_Human	1.29606959
22	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.26745944
23	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.19403946
24	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.19401602
25	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.18688981
26	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.17020838
27	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.12889270
28	IGF1R_20145208_ChIP-Seq_DFB_Human	1.11754240
29	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10817473
30	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.09640807
31	GBX2_23144817_ChIP-Seq_PC3_Human	1.06542093
32	ER_23166858_ChIP-Seq_MCF-7_Human	1.02606599
33	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.01275223
34	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.99974740
35	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.98603918
36	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	0.96289546
37	GATA2_19941826_ChIP-Seq_K562_Human	0.95803782
38	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.94955330
39	CJUN_26792858_Chip-Seq_BT549_Human	0.94475855
40	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.92225194
41	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	0.91983305
42	FUS_26573619_Chip-Seq_HEK293_Human	0.91069927
43	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.90945715
44	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.89151963
45	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.88175029
46	GATA1_19941826_ChIP-Seq_K562_Human	0.87660337
47	GF1B_26923725_Chip-Seq_HPCs_Mouse	0.87393074
48	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.87196295
49	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.85798078
50	CBP_20019798_ChIP-Seq_JUKART_Human	0.85505149
51	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.85505149
52	AHR_22903824_ChIP-Seq_MCF-7_Human	0.83884320
53	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.83545159
54	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.82235878
55	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	0.82022648
56	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	0.81541332
57	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.81379572
58	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.80917759
59	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.79915922
60	GF1_26923725_Chip-Seq_HPCs_Mouse	0.79053107
61	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.76872744
62	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.76495411
63	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.76160722
64	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.74980179
65	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.74323575
66	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.74091577
67	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.74091577
68	STAT3_23295773_ChIP-Seq_U87_Human	0.73777143
69	ZNF274_21170338_ChIP-Seq_K562_Hela	0.73743050
70	LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.73660427
71	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.72645889
72	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.72005732
73	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	0.71534348
74	KDM2B_26808549_Chip-Seq_REH_Human	0.70873502
75	TAF15_26573619_Chip-Seq_HEK293_Human	0.70185874
76	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.69765117
77	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.69764177
78	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.69383601
79	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.69383601
80	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.68496486
81	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.68292460
82	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.67806863
83	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.67201797
84	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.67021651
85	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.66505722
86	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.65373297
87	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.64993955
88	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.63835832
89	SMAD4_21799915_ChIP-Seq_A2780_Human	0.60742383
90	RXR_22108803_ChIP-Seq_LS180_Human	0.60662375
91	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.60429680
92	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.60058172
93	FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human	0.59736958
94	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.59716165
95	ETS1_22383799_ChIP-Seq_G1ME_Mouse	0.59590959
96	JUN_21703547_ChIP-Seq_K562_Human	0.59495340
97	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.59366469
98	UBF1/2_26484160_Chip-Seq_HMECs_Human	0.59236600
99	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.58963596
100	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.58471354

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.94373432
2	MP0009764_decreased_sensitivity_to	4.45309907
3	MP0002877_abnormal_melanocyte_morpholog	4.30779475
4	MP0005084_abnormal_gallbladder_morpholo	3.93215723
5	MP0003221_abnormal_cardiomyocyte_apopto	3.13087668
6	MP0005451_abnormal_body_composition	3.04495969
7	MP0000371_diluted_coat_color	3.02616293
8	MP0003252_abnormal_bile_duct	2.86487003
9	MP0009840_abnormal_foam_cell	2.72466177
10	MP0004233_abnormal_muscle_weight	2.66180754
11	MP0002928_abnormal_bile_duct	2.57238050
12	MP0005167_abnormal_blood-brain_barrier	2.51701970
13	MP0003693_abnormal_embryo_hatching	2.16508260
14	MP0003950_abnormal_plasma_membrane	2.09842275
15	MP0003183_abnormal_peptide_metabolism	1.98409394
16	MP0008872_abnormal_physiological_respon	1.78609425
17	MP0002090_abnormal_vision	1.78528284
18	MP0000750_abnormal_muscle_regeneration	1.78044768
19	MP0003828_pulmonary_edema	1.77026582
20	MP0004134_abnormal_chest_morphology	1.72717666
21	MP0005409_darkened_coat_color	1.67594758
22	MP0000013_abnormal_adipose_tissue	1.64204782
23	MP0003656_abnormal_erythrocyte_physiolo	1.63857533
24	MP0001879_abnormal_lymphatic_vessel	1.59970707
25	MP0002075_abnormal_coat/hair_pigmentati	1.55999799
26	MP0004270_analgesia	1.53290570
27	MP0004264_abnormal_extraembryonic_tissu	1.51856508
28	MP0008770_decreased_survivor_rate	1.51765198
29	MP0002932_abnormal_joint_morphology	1.50502662
30	MP0004272_abnormal_basement_membrane	1.48477028
31	MP0005464_abnormal_platelet_physiology	1.42723229
32	MP0005083_abnormal_biliary_tract	1.40666493
33	MP0003646_muscle_fatigue	1.36375302
34	MP0008004_abnormal_stomach_pH	1.34941275
35	MP0000343_altered_response_to	1.34713466
36	MP0005187_abnormal_penis_morphology	1.33791909
37	MP0002138_abnormal_hepatobiliary_system	1.33160416
38	MP0005410_abnormal_fertilization	1.25959379
39	MP0002009_preneoplasia	1.25610070
40	MP0002160_abnormal_reproductive_system	1.25383997
41	MP0004130_abnormal_muscle_cell	1.23045872
42	MP0000747_muscle_weakness	1.21373360
43	MP0001270_distended_abdomen	1.18006944
44	MP0001186_pigmentation_phenotype	1.17816886
45	MP0000163_abnormal_cartilage_morphology	1.15597219
46	MP0004484_altered_response_of	1.14759679
47	MP0004885_abnormal_endolymph	1.10127284
48	MP0002127_abnormal_cardiovascular_syste	1.09835883
49	MP0000678_abnormal_parathyroid_gland	1.08921189
50	MP0000003_abnormal_adipose_tissue	1.08730699
51	MP0000749_muscle_degeneration	1.08431677
52	MP0002638_abnormal_pupillary_reflex	1.06171887
53	MP0008260_abnormal_autophagy	1.03745153
54	MP0002419_abnormal_innate_immunity	1.03467915
55	MP0005220_abnormal_exocrine_pancreas	1.01522137
56	MP0003567_abnormal_fetal_cardiomyocyte	1.00938423
57	MP0002332_abnormal_exercise_endurance	0.97008183
58	MP0003315_abnormal_perineum_morphology	0.95816885
59	MP0002095_abnormal_skin_pigmentation	0.91639833
60	MP0000613_abnormal_salivary_gland	0.91583477
61	MP0009115_abnormal_fat_cell	0.90667320
62	MP0001544_abnormal_cardiovascular_syste	0.88860049
63	MP0005385_cardiovascular_system_phenoty	0.88860049
64	MP0009250_abnormal_appendicular_skeleto	0.87987559
65	MP0003633_abnormal_nervous_system	0.87316625
66	MP0004215_abnormal_myocardial_fiber	0.87224904
67	MP0003011_delayed_dark_adaptation	0.84483585
68	MP0003436_decreased_susceptibility_to	0.83727335
69	MP0000049_abnormal_middle_ear	0.82588601
70	MP0009765_abnormal_xenobiotic_induced	0.82085355
71	MP0006138_congestive_heart_failure	0.81904845
72	MP0000609_abnormal_liver_physiology	0.81565737
73	MP0004133_heterotaxia	0.81477039
74	MP0005166_decreased_susceptibility_to	0.81195503
75	MP0005076_abnormal_cell_differentiation	0.81148005
76	MP0002111_abnormal_tail_morphology	0.81140494
77	MP0000733_abnormal_muscle_development	0.80355559
78	MP0003303_peritoneal_inflammation	0.79693789
79	MP0002972_abnormal_cardiac_muscle	0.79075844
80	MP0002089_abnormal_postnatal_growth/wei	0.77867664
81	MP0009046_muscle_twitch	0.76771650
82	MP0005389_reproductive_system_phenotype	0.73185312
83	MP0000631_abnormal_neuroendocrine_gland	0.72093550
84	MP0001324_abnormal_eye_pigmentation	0.70510097
85	MP0006276_abnormal_autonomic_nervous	0.67689171
86	MP0003091_abnormal_cell_migration	0.67277594
87	MP0002163_abnormal_gland_morphology	0.66842754
88	MP0004197_abnormal_fetal_growth/weight/	0.66703137
89	MP0002452_abnormal_antigen_presenting	0.65730199
90	MP0005164_abnormal_response_to	0.65164477
91	MP0003959_abnormal_lean_body	0.64035193
92	MP0010234_abnormal_vibrissa_follicle	0.63957809
93	MP0002139_abnormal_hepatobiliary_system	0.62938738
94	MP0001175_abnormal_lung_morphology	0.62454046
95	MP0005423_abnormal_somatic_nervous	0.62385473
96	MP0002106_abnormal_muscle_physiology	0.61613040
97	MP0005334_abnormal_fat_pad	0.61581869
98	MP0002113_abnormal_skeleton_development	0.60723899
99	MP0003631_nervous_system_phenotype	0.58230366
100	MP0001191_abnormal_skin_condition	0.58173051

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hemiplegia (HP:0002301)	6.11331047
2	Myelomeningocele (HP:0002475)	5.25009565
3	Abnormality of the intervertebral disk (HP:0005108)	5.09899006
4	Abnormality of the odontoid process (HP:0003310)	5.01518528
5	Rough bone trabeculation (HP:0100670)	4.88227478
6	Tongue fasciculations (HP:0001308)	4.56292456
7	Slow saccadic eye movements (HP:0000514)	4.47098011
8	Muscle fibrillation (HP:0010546)	4.46109512
9	Short femoral neck (HP:0100864)	4.44414587
10	Premature graying of hair (HP:0002216)	4.27397794
11	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	3.92415553
12	Pathologic fracture (HP:0002756)	3.89518865
13	Abnormal trabecular bone morphology (HP:0100671)	3.86684273
14	Vertebral fusion (HP:0002948)	3.81433782
15	Hemivertebrae (HP:0002937)	3.57176667
16	Prominent occiput (HP:0000269)	3.27629142
17	Aplasia/hypoplasia of the femur (HP:0005613)	3.19975145
18	Oligodontia (HP:0000677)	3.07213830
19	Impaired smooth pursuit (HP:0007772)	3.02157994
20	Morphological abnormality of the pyramidal tract (HP:0002062)	2.97706157
21	Meningocele (HP:0002435)	2.91863865
22	Aplasia/Hypoplasia involving the pelvis (HP:0009103)	2.74736556
23	Bone marrow hypocellularity (HP:0005528)	2.64071991
24	Duplicated collecting system (HP:0000081)	2.60121363
25	Abnormality of the renal collecting system (HP:0004742)	2.52752909
26	Spina bifida occulta (HP:0003298)	2.35042413
27	Abnormality of ocular smooth pursuit (HP:0000617)	2.31905251
28	Deformed sella turcica (HP:0002681)	2.26880924
29	Ankyloglossia (HP:0010296)	2.24639432
30	Cellular immunodeficiency (HP:0005374)	2.19889782
31	Persistence of primary teeth (HP:0006335)	2.18183713
32	Abnormality of the lumbar spine (HP:0100712)	2.16040765
33	Calf muscle hypertrophy (HP:0008981)	2.08311928
34	Abnormality of pyrimidine metabolism (HP:0004353)	2.03590940
35	Amelogenesis imperfecta (HP:0000705)	2.02968159
36	Oral leukoplakia (HP:0002745)	12.0842314
37	Anomalous pulmonary venous return (HP:0010772)	12.0076657
38	Abnormality of the pulmonary veins (HP:0011718)	10.6311048
39	Sparse lateral eyebrow (HP:0005338)	1.98140880
40	Adactyly (HP:0009776)	1.97965309
41	Hamartoma of the eye (HP:0010568)	1.95639445
42	Anonychia (HP:0001798)	1.94419694
43	Blepharitis (HP:0000498)	1.93716136
44	Broad forehead (HP:0000337)	1.90177188
45	Drooling (HP:0002307)	1.89625898
46	Aplasia cutis congenita (HP:0001057)	1.88327153
47	J-shaped sella turcica (HP:0002680)	1.88178015
48	Aortic regurgitation (HP:0001659)	1.86250311
49	Short thorax (HP:0010306)	1.86001906
50	Ureteral duplication (HP:0000073)	1.82414923
51	Aseptic necrosis (HP:0010885)	1.81300043
52	Osteomalacia (HP:0002749)	1.80449268
53	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.79777843
54	Abnormality of the nasal septum (HP:0000419)	1.79527099
55	Neoplasm of the pancreas (HP:0002894)	1.79029864
56	Muscle hypertrophy of the lower extremities (HP:0008968)	1.78443239
57	Abnormality of the frontal sinuses (HP:0002687)	1.78400914
58	Abnormal pancreas size (HP:0012094)	1.77309883
59	Hyporeflexia of lower limbs (HP:0002600)	1.76071381
60	Broad ribs (HP:0000885)	1.74984198
61	Syringomyelia (HP:0003396)	1.74477603
62	Spinal cord lesions (HP:0100561)	1.74477603
63	Genetic anticipation (HP:0003743)	1.73674933
64	Ectopic kidney (HP:0000086)	1.72123961
65	Upper motor neuron abnormality (HP:0002127)	1.71130357
66	Neoplasm of the heart (HP:0100544)	1.70327302
67	Difficulty climbing stairs (HP:0003551)	1.69617072
68	Excessive salivation (HP:0003781)	1.68495620
69	Alveolar cell carcinoma (HP:0006519)	1.67132254
70	Pelvic girdle muscle weakness (HP:0003749)	1.66291150
71	Hypoplastic pelvis (HP:0008839)	1.64876309
72	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.63081601
73	Postnatal growth retardation (HP:0008897)	1.62659351
74	Abnormality of DNA repair (HP:0003254)	1.59462971
75	Abnormality of saccadic eye movements (HP:0000570)	1.58177187
76	Postural tremor (HP:0002174)	1.56577989
77	Abnormality of the pons (HP:0007361)	1.55786498
78	Long toe (HP:0010511)	1.55713504
79	Shoulder girdle muscle weakness (HP:0003547)	1.55710345
80	Neoplasm of the tracheobronchial system (HP:0100552)	1.55112632
81	Subacute progressive viral hepatitis (HP:0006572)	1.53013561
82	Hematochezia (HP:0002573)	1.52617313
83	Generalized hypopigmentation of hair (HP:0011358)	1.50538148
84	Death in childhood (HP:0003819)	1.49083896
85	Tracheoesophageal fistula (HP:0002575)	1.48663318
86	Limb-girdle muscle atrophy (HP:0003797)	1.46528977
87	Abnormality of the sella turcica (HP:0002679)	1.45989866
88	Decreased circulating renin level (HP:0003351)	1.43593593
89	Periauricular skin pits (HP:0100277)	1.43206573
90	Preauricular pit (HP:0004467)	1.43206573
91	Rectal prolapse (HP:0002035)	1.43152932
92	Abnormality of the preputium (HP:0100587)	1.42448287
93	Short nail (HP:0001799)	1.37100620
94	Thickened calvaria (HP:0002684)	1.36923885
95	Conjunctival hamartoma (HP:0100780)	1.36848043
96	Small hand (HP:0200055)	1.36685778
97	Skin pits (HP:0100276)	1.36578187
98	Osteoporosis (HP:0000939)	1.36065787
99	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	1.35438348
100	Short 4th metacarpal (HP:0010044)	1.35438348

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BLK	9.97199464
2	IRAK3	6.72812991
3	TLK1	4.34006630
4	MAP2K7	3.91089989
5	MAP3K4	3.87929778
6	ZAK	3.48762097
7	MAP2K4	2.61487060
8	PKN2	2.53524476
9	CAMK1D	2.17863744
10	STK24	1.99779930
11	CAMKK2	1.77158799
12	CAMK1G	1.57789499
13	FLT3	1.35046782
14	NEK9	1.34182319
15	STK38L	1.17938642
16	VRK1	1.17091856
17	RET	1.13143786
18	MAP3K2	1.06203148
19	TGFBR2	1.01724903
20	STK4	0.92883704
21	MAP3K6	0.90992503
22	CAMK4	0.90125034
23	SYK	0.82845347
24	CSK	0.81312607
25	GRK7	0.77050961
26	TRPM7	0.74373029
27	KSR2	0.66594273
28	SGK2	0.64628085
29	PLK2	0.62767824
30	PKN1	0.62433564
31	PIM1	0.61231249
32	RPS6KA5	0.61072993
33	SGK3	0.60866202
34	MAP3K5	0.59767164
35	WNK1	0.55022724
36	CDK9	0.54767042
37	AKT3	0.54287816
38	STK3	0.52116678
39	TAF1	0.49918453
40	LYN	0.49606976
41	FGFR1	0.47756882
42	DAPK3	0.46759845
43	ADRBK2	0.45445660
44	MOS	0.45356376
45	PRKCI	0.43048326
46	CSNK1A1L	0.40301715
47	GRK1	0.40096874
48	TNIK	0.39370964
49	MAP3K9	0.39236887
50	RPS6KA2	0.37834559
51	PIK3CG	0.37150946
52	SCYL2	0.36950804
53	ERBB4	0.36856758
54	MAP3K8	0.35748791
55	MAP2K3	0.35360346
56	SGK494	0.35341386
57	SGK223	0.35341386
58	BMPR2	0.35100409
59	PRKAA1	0.34712157
60	AURKA	0.33149667
61	PDGFRB	0.32801552
62	RPS6KA6	0.32655267
63	KSR1	0.31822005
64	MAP3K14	0.30559891
65	PDK1	0.30053329
66	JAK2	0.30009336
67	ZAP70	0.29528508
68	EGFR	0.29109091
69	EEF2K	0.29092182
70	RPS6KC1	0.28400627
71	RPS6KL1	0.28400627
72	OBSCN	0.27660845
73	TAOK3	0.27227655
74	AKT2	0.26462538
75	MKNK2	0.25889573
76	MELK	0.23020334
77	MAPK11	0.22707759
78	DAPK2	0.21864074
79	MAPK4	0.20321483
80	FGFR3	0.19825131
81	CAMKK1	0.19234846
82	CSNK1G3	0.18864711
83	INSR	0.17975489
84	PDPK1	0.17888560
85	RAF1	0.17638707
86	FYN	0.16911160
87	RPS6KB1	0.15101457
88	RIPK4	0.14966972
89	ERBB2	0.14822690
90	PRKAA2	0.14322834
91	HIPK2	0.14049810
92	EIF2AK3	0.13104579
93	CAMK1	0.11877510
94	LATS1	0.10930172
95	CSNK1G2	0.10845506
96	CSNK1G1	0.10115023
97	CDK6	0.10063238
98	IGF1R	0.09213071
99	ABL2	0.08891814
100	CAMK2A	0.08696931

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Systemic lupus erythematosus_Homo sapiens_hsa05322	5.68769668
2	Sulfur metabolism_Homo sapiens_hsa00920	4.03490931
3	Alcoholism_Homo sapiens_hsa05034	3.58625328
4	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	2.15545626
5	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	2.12276743
6	Viral carcinogenesis_Homo sapiens_hsa05203	1.80922853
7	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.79647293
8	GnRH signaling pathway_Homo sapiens_hsa04912	1.70052311
9	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.65824989
10	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.63098088
11	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.56763372
12	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.56704119
13	Platelet activation_Homo sapiens_hsa04611	1.49490351
14	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.48705864
15	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.45403158
16	Leishmaniasis_Homo sapiens_hsa05140	1.45213879
17	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.43233297
18	Selenocompound metabolism_Homo sapiens_hsa00450	1.35382434
19	Bladder cancer_Homo sapiens_hsa05219	1.31787436
20	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.31715966
21	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.30416925
22	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.30131153
23	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.25045520
24	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.23854361
25	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.23836435
26	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.23482163
27	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.21935301
28	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.19416611
29	Gap junction_Homo sapiens_hsa04540	1.19383839
30	Osteoclast differentiation_Homo sapiens_hsa04380	1.16018485
31	TNF signaling pathway_Homo sapiens_hsa04668	1.12017642
32	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.11011671
33	Chemokine signaling pathway_Homo sapiens_hsa04062	1.09521703
34	Type II diabetes mellitus_Homo sapiens_hsa04930	1.06291041
35	Insulin secretion_Homo sapiens_hsa04911	1.05695580
36	Morphine addiction_Homo sapiens_hsa05032	1.05639547
37	Estrogen signaling pathway_Homo sapiens_hsa04915	1.01223743
38	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.98765353
39	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.93524488
40	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.92593825
41	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.92555003
42	mTOR signaling pathway_Homo sapiens_hsa04150	0.92107406
43	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.91012629
44	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.90618687
45	Gastric acid secretion_Homo sapiens_hsa04971	0.90275194
46	Cholinergic synapse_Homo sapiens_hsa04725	0.89414943
47	cAMP signaling pathway_Homo sapiens_hsa04024	0.89244402
48	Tuberculosis_Homo sapiens_hsa05152	0.84100562
49	Other glycan degradation_Homo sapiens_hsa00511	0.82538681
50	Prolactin signaling pathway_Homo sapiens_hsa04917	0.81739896
51	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.81252197
52	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.79978524
53	Glutamatergic synapse_Homo sapiens_hsa04724	0.78874396
54	Pancreatic cancer_Homo sapiens_hsa05212	0.78244510
55	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.77283277
56	Salivary secretion_Homo sapiens_hsa04970	0.76374267
57	Bile secretion_Homo sapiens_hsa04976	0.75966985
58	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.75893565
59	Melanogenesis_Homo sapiens_hsa04916	0.74907940
60	Amoebiasis_Homo sapiens_hsa05146	0.74782511
61	GABAergic synapse_Homo sapiens_hsa04727	0.74117076
62	ErbB signaling pathway_Homo sapiens_hsa04012	0.74008872
63	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.70949753
64	Circadian entrainment_Homo sapiens_hsa04713	0.70571578
65	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.70103210
66	PPAR signaling pathway_Homo sapiens_hsa03320	0.70089641
67	Pancreatic secretion_Homo sapiens_hsa04972	0.69616207
68	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.68512813
69	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.66990250
70	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.65644970
71	Influenza A_Homo sapiens_hsa05164	0.65302521
72	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.64109701
73	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.63658706
74	Vibrio cholerae infection_Homo sapiens_hsa05110	0.63589442
75	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.62842296
76	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.61469772
77	Insulin resistance_Homo sapiens_hsa04931	0.61421883
78	Taste transduction_Homo sapiens_hsa04742	0.61301147
79	Melanoma_Homo sapiens_hsa05218	0.60635837
80	Olfactory transduction_Homo sapiens_hsa04740	0.59912656
81	MAPK signaling pathway_Homo sapiens_hsa04010	0.58663828
82	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.58386431
83	Calcium signaling pathway_Homo sapiens_hsa04020	0.57056350
84	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.52304529
85	Oocyte meiosis_Homo sapiens_hsa04114	0.51437579
86	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.50176635
87	FoxO signaling pathway_Homo sapiens_hsa04068	0.50139401
88	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.50058830
89	Hepatitis B_Homo sapiens_hsa05161	0.45899817
90	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.45083031
91	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.44418449
92	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.43463018
93	Complement and coagulation cascades_Homo sapiens_hsa04610	0.42056593
94	Apoptosis_Homo sapiens_hsa04210	0.41925779
95	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.41748914
96	Rap1 signaling pathway_Homo sapiens_hsa04015	0.38934962
97	Choline metabolism in cancer_Homo sapiens_hsa05231	0.38859618
98	Acute myeloid leukemia_Homo sapiens_hsa05221	0.37416576
99	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.35416257
100	Renin-angiotensin system_Homo sapiens_hsa04614	0.35036987

ZBED9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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